question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Do high incidence of mild hyponatraemia in females using ecstasy at a rave party?
### Response:
| Only 3% of males, but no less than ∼25% of females attending a rave party and using MDMA developed mild hyponatraemia during the event. Especially females are therefore probably also at risk of developing severe symptomatic hyponatraemia. Not using MDMA is obviously the best option to prevent MDMA-induced hyponatraemia. However, accepting the fact that millions use the drug every weekend, strategies should also be developed to prevent hyponatraemia in subjects choosing to take MDMA. This would include matching the electrolyte content of the fluids and food ingested to that of the fluids that are lost during the use of MDMA, mainly by perspiration. Users of MDMA and emergency health care workers should become more aware of the relatively high incidence of MDMA-induced hyponatraemia and of potential strategies to prevent this complication. |
### Instruction:
Does preoperative magnetic resonance spectroscopy improve diagnostic accuracy in a series of neurosurgical dilemmas?
### Response:
| Our study supports a beneficial role for (1)H MRS in certain diagnostic intracranial dilemmas presenting to neurosurgeons. The information gleaned from preoperative (1)H MRS can be a useful adjunct to clinical and conventional MR imaging data in guiding the management of patients with intracranial pathologies, particularly high-grade tumour versus abscess, and high-grade versus low-grade glioma. Further larger prospective studies are needed to clearly define the utility of (1)H MRS in diagnostically challenging intracranial lesions in neurosurgery. |
### Instruction:
Does the lysine deacetylase inhibitor Givinostat inhibit β-cell IL-1β induced IL-1β transcription and processing?
### Response:
| Inhibition of β-cell IL-1β expression and processing and Cxcl10 transcription contributes to the β-cell protective actions of KDACi. In vitro β-cell destructive effects of CXCL10 are not mediated via IL-1β transcription. The differential proinflammatory actions of KDACs may be attractive novel drug targets in DM. |
### Instruction:
Is painless myocardial ischemia associated with mortality in patients with chronic kidney disease?
### Response:
| PMI is common in the CKD population, is inversely related to the level of eGFR, and confers a substantially increased risk in CKD. These findings may partially explain the high mortality traditionally attributed to cardiovascular disease in CKD patients. |
### Instruction:
Do young colorectal carcinoma patients have a poorer prognosis : a comparative review of 2,426 cases?
### Response:
| Although presenting with advanced tumors and with poorer prognostic factors such as presence of mucin and poor histological differentiation, young CRC patients do not have a worse prognosis. |
### Instruction:
Are focal adhesion dynamics altered in schizophrenia?
### Response:
| The evidence for altered motility and focal adhesion dynamics in patient-derived cells is consistent with dysregulated gene expression in the FAK signaling pathway in these cells. Alterations in cell adhesion dynamics and cell motility could bias the trajectory of brain development in schizophrenia. |
### Instruction:
Does laparoscopic appendectomy for perforated appendicitis in children have complication rates comparable with those of open appendectomy?
### Response:
| We report that LA is superior to OA with regard to incidence of re-admission, re-operation, and wound infection. |
### Instruction:
Does asparagus racemosus modulate the hypothalamic-pituitary-adrenal axis and brain monoaminergic systems in rats?
### Response:
| MAR showed a physiological modulation of the stress pathways. Interestingly, in most brain regions the change in monoaminergic systems was limited by a ceiling effect at a dose of 100 mg/kg. These observations could explain the traditional use of AR as an adaptogen and a functional food. |
### Instruction:
Is respiratory syncytial virus infection strongly correlated with decreased mean platelet volume?
### Response:
| We conclude that infection with RSV is associated with decreased MPV and this may be clinically useful in children undergoing bronchoscopy. |
### Instruction:
Does 14-3-3ε mediate the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage?
### Response:
| Our data demonstrated on a systems view that 14-3-3ε coordinates multiple biological pathways involved in BLM-induced DDR in HCC cells. Specifically, 14-3-3ε associates with TAK1 in a phosphorylation-dependent manner to determine the cell fate of BLM-treated HCC cells. Not only individual proteins but also those critical links in the network could be the potential targets for BLM-mediated therapeutic intervention of HCC. |
### Instruction:
Does mucosal healing at 3 months predict long-term endoscopic remission in anti-TNF-treated luminal Crohn 's disease?
### Response:
| In anti-TNF-treated active luminal CD mucosal healing at 3 months is a strong predictor for long-term endoscopic response. |
### Instruction:
Do relationship between the use of new or used computed tomography scanners and image retake rates in South Korea?
### Response:
| The quality control associated with import of used CT scanners should be improved. Moreover, regular and detailed quality inspections of used CT scanners currently operating in healthcare institutions are necessary. |
### Instruction:
Do vEGF and TSP1 levels correlate with prognosis in advanced non-small cell lung cancer?
### Response:
| Angiogenesis, inflammation and coagulation markers were increased in NSCLC patients. Increased levels of VEGF and low levels of TSP-1 correlated with a poor prognosis. |
### Instruction:
Is cASQ1 gene an unlikely candidate for malignant hyperthermia susceptibility in the North American population?
### Response:
| This study revealed a low level of protein coding sequence variability within the human CASQ1 gene, indicating that CASQ1 is not a major MHS locus in the North American population. |
### Instruction:
Is apathy associated with activities of daily living ability in Parkinson 's disease?
### Response:
| Apathy was significantly associated with ADL in PD. The result indicates that more attention should be paid to identifying apathy and targeting therapeutic interventions. |
### Instruction:
Are blastocyst biopsy and vitrification effective for preimplantation genetic diagnosis of monogenic diseases?
### Response:
| This strategy is highly effective for PGD of monogenic diseases and merits wide use. |
### Instruction:
Does gene expression analysis reveal functional pathways of glatiramer acetate activation?
### Response:
| GA-induced functional pathways coincide with known mechanisms of GA activity in MS patients and further support the unique therapeutic effect of this drug. |
### Instruction:
Does transglutaminase 2 accelerate vascular calcification in chronic kidney disease?
### Response:
| These data demonstrate a role of TGM2 in the pathogenesis of vascular calcification in CKD through enhancement of MV-ECM calcification. |
### Instruction:
Does neuron-derived orphan receptor 1 promote proliferation of quiescent hepatocytes?
### Response:
| In mice, the orphan nuclear receptor Nor-1 activates proliferation of quiescent hepatocytes and is required for hepatocyte proliferation after partial hepatectomy. Nor-1 and its gene targets are also up-regulated in human HCC samples. Nor-1 activates a transcriptional program that induces hepatocyte proliferation independently of inflammatory signaling pathways. |
### Instruction:
Are cholera outbreaks in Nigeria associated with multidrug resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae?
### Response:
| The recent Nigeria outbreaks have been determined by multidrug resistant atypical El Tor and non-O1/non-O139 V. cholerae strains, and it seems that the typical El Tor, from the beginning of seventh cholera pandemic, is no longer epidemic/endemic in this country. This scenario is similar to the East Africa, Asia and Caribbean countries. The detection of a highly virulent, antimicrobial resistant lineage in Nigeria is worrisome and points to a need for vaccine-based control of the disease. This study has also revealed the putative importance of non-O1/non-O139 V. cholerae in diarrheal disease in Nigeria. |
### Instruction:
Does combined donor simvastatin and methylprednisolone treatment prevent ischemia-reperfusion injury in rat cardiac allografts through vasculoprotection and immunomodulation?
### Response:
| Our results show that donor treatment in combination with simvastatin and methylprednisolone prevents IRI and has beneficial effect on allograft survival in rat cardiac allografts. Minimizing microvascular injury and the activation of innate immunity may offer a novel therapeutic strategy to expand the donor pool and furthermore improve the function of the marginal donor organs. |
### Instruction:
Does industrial hemp decrease intestinal motility stronger than indian hemp in mice?
### Response:
| Although not completely without psychotropic activity cannabidiol could be a potential replacement for tetrahydrocannabinol. Since industrial hemp infuse rich in cannabidiol reduces intestinal motility in healthy mice cannabidiol should be further evaluated for the treatment of intestinal hypermotility. |
### Instruction:
Do validity and reliability of the FIM instrument in the inpatient burn rehabilitation population?
### Response:
| The FIM instrument has evidence of validity and reliability as an outcome measure for patients with burn injuries in the inpatient rehabilitation setting. The 6-subfactor model provides a better fit than the 2-factor model by confirmatory factor analysis. There is evidence that the motor and cognitive domains each form valid unidimensional metrics based on nonparametric item response theory. |
### Instruction:
Are elevated circulating levels of osteopontin associated with metastasis in advanced non-small cell lung cancer?
### Response:
| Preoperative plasma levels of osteopontin are significantly associated with post-operative metastasis in advanced NSCLC. |
### Instruction:
Does latitude modify the effect size of factors related to recurrent wheeze in the first year of life?
### Response:
| The magnitude in which some risk/protective factors are associated to recurrent wheeze during the first year of life varies significantly with latitude. |
### Instruction:
Is escherichia coli sequence type 131 a dominant , antimicrobial-resistant clonal group associated with healthcare and elderly hosts?
### Response:
| ST131 is a dominant, antimicrobial-resistant clonal group associated with healthcare settings, elderly hosts, and persistent or recurrent symptoms. |
### Instruction:
Does angiopoietin-1 mediate adipose tissue-derived stem cell-induced inhibition of neointimal formation in rat femoral artery?
### Response:
| Ang1 was implicated in ASC-induced suppression of neointimal formation. The results also suggested that Ang1 inhibited neointimal formation via stimulation of reendothelialization and suppression of macrophage infiltration in the neointima. |
### Instruction:
Is single-session endosonography and endoscopic retrograde cholangiopancreatography for biliopancreatic diseases feasible , effective and cost beneficial?
### Response:
| Combined EUS and ERCP is safe, technically feasible and cost beneficial. Furthermore, in failed ERCP cases, the endoscopic biliary drainage can be completed with EUS-guided biliary access in the same procedure. |
### Instruction:
Is androgen receptor widely expressed in bovine placentomes and up-regulated during differentiation of bovine trophoblast giant cells?
### Response:
| The results are consistent with androgens as active products of bovine placental steroidogenesis. The substantial up-regulation of AR expression during TGC differentiation suggests that androgens may be related to this process. |
### Instruction:
Does macrophage migration inhibitory factor induce contractile and mitochondria dysfunction by altering cytoskeleton network in the human heart?
### Response:
| MIF depresses human myocardial contractile function and impairs mitochondrial respiration. Changes in microtubule network likely promote MIF-induced cardiac dysfunction by 1) altering with mitochondrial tubular assembly and outer membrane permeability for adenine nucleotides leading to energy deficit, 2) excessive tubulin polymerization that may impede cardiomyocyte viscosity and motion, and 3) interfering with AMPK pathway. |
### Instruction:
Do elevated plasma hemoglobin levels increase nitric oxide consumption in experimental and clinical acute pulmonary thromboembolism?
### Response:
| Our results show consistent evidence indicating a new mechanism involving increased hemoglobin decompartmentalization and augmented nitric oxide consumption, possibly contributing to the hemodynamic derangement of acute pulmonary thromboembolism. |
### Instruction:
Is how acute kidney injury investigated and managed in UK intensive care units -- a survey of current practice?
### Response:
| Considerable variation exists in the investigation and management of AKI in UK ICUs. Despite increasing recognition of the importance of AKI, few ICUs are aware of RIFLE and AKIN criteria. |
### Instruction:
Does histologic versus pH probe result in pediatric laryngopharyngeal reflux?
### Response:
| Eighty percent of our patients (40) were either positive for reflux by pH probe or by pH probe and biopsy. The Restech Dx-pH Measurement System appeared to be well tolerated in all age groups. There were no complications. We found this a useful tool in confirming clinical suspicion of LPR. |
### Instruction:
Is transcription factor Sox11 essential for both embryonic and adult neurogenesis?
### Response:
| Taken together, our work provides evidence that Sox11 is required for both embryonic and adult neurogenesis, and identifies potential downstream target genes. |
### Instruction:
Do curcuminoids limit neutrophil-mediated reperfusion injury in experimental stroke by targeting the endothelium?
### Response:
| Turmeric-derived curcuminoids limit reperfusion injury in stroke by preventing neutrophil adhesion to the cerebrovascular microcirculation and improving shear rate by targeting the endothelium. |
### Instruction:
Is familial longevity marked by better cognitive performance at middle age : the Leiden Longevity Study?
### Response:
| Offspring of nonagenarian siblings with a familial history of longevity have better cognitive performance compared to the group of their partners of comparable age. This effect is independent of age-related diseases and known possible confounders. Possible explanations might be differences in subclinical vascular pathology between both groups. |
### Instruction:
Does 14-3-3ε overexpression contribute to epithelial-mesenchymal transition of hepatocellular carcinoma?
### Response:
| Our findings show for the first time that E-cadherin is one of the downstream targets of 14-3-3ε in modulating HCC tumor progression. Thus, 14-3-3ε may act as an important regulator in modulating tumor metastasis by promoting EMT as well as cell migration, and it may serve as a novel prognostic biomarker or therapeutic target for HCC. |
### Instruction:
Does ultrasound exposure improve the targeted therapy effects of galactosylated docetaxel nanoparticles on hepatocellular carcinoma xenografts?
### Response:
| Ultrasound exposure can improve targeting nanoparticles accumulation in the tumor, and achieve a synergism antitumor effect on the hepatocellular carcinoma xenografts. |
### Instruction:
Does local delivery of bupivacaine in the wound reduce opioid requirements after intraabdominal surgery in children?
### Response:
| Continuous infusion of bupivacaine in the abdominal wound was effective in reducing postoperative pain in children. It significantly reduced the need for additional opioids and can be considered for postoperative pain management in children. |
### Instruction:
Is attenuation of live respiratory syncytial virus vaccines associated with reductions in levels of nasal cytokines?
### Response:
| Substantial increases in proinflammatory, antiinflammatory, T-helper 1, T-helper 2, and regulatory cytokines were detected in children who received minimally attenuated live RSV vaccines but not in children who received highly attenuated vaccines. Levels of cytokines in NW specimens may be useful biomarkers of attenuation for live RSV vaccines. |
### Instruction:
Does thioridazine lack bactericidal activity in an animal model of extracellular tuberculosis?
### Response:
| Thioridazine has limited bactericidal activity against extracellular bacilli within necrotic granulomas. Its contribution to the sterilizing activity of combination regimens against drug-susceptible and drug-resistant tuberculosis remains to be determined. |
### Instruction:
Is during twenty years of Cisplatin-based therapy the face of nonseminomatous testicular germ cell tumors still changing : an evaluation of presentation , management , predictive factors and survival?
### Response:
| In our single institution study the face of NSGCT markedly changed over 20 years even after the introduction of Cisplatin-based chemotherapy. These changes were accompanied by an improvement in RFS and CSS. When dealing with NSGCT patients such observations now and in the future should be taken into account. |
### Instruction:
Do time to menarche and final height after histrelin implant treatment for central precocious puberty?
### Response:
| Menarche occurred sooner after implant removal. There was no difference in final height or BMI outcomes between the 2 treatment modalities. |
### Instruction:
Is neopterin a cerebrospinal fluid marker for treatment outcome evaluation in patients affected by Trypanosoma brucei gambiense sleeping sickness?
### Response:
| In the present study, neopterin was highlighted as a useful marker for the evaluation of the post-therapeutic outcome in patients suffering from sleeping sickness. Detectable levels of this marker in the CSF have the potential to shorten the follow-up for HAT patients to six months after the end of the treatment. |
### Instruction:
Is inhibition of signal transducer and activator of transcription 3 and cyclooxygenase-2 involved in radiosensitization of cepharanthine in HeLa cells?
### Response:
| Cepharanthine was shown to induce radiation sensitization in HeLa cells in vitro and in vivo. The inhibitory effects of CEP on STAT3 signaling pathway and COX-2 help us to better understand the radiosensitization of CEP. |
### Instruction:
Does self-esteem variability predict arterial stiffness trajectories in healthy adolescent females?
### Response:
| These findings suggest that fluctuating self-esteem may accelerate the early stages of vascular stiffening in young women, regardless of whether self-views are generally positive or negative. |
### Instruction:
Does previous transanal endoscopic microsurgery for rectal cancer represent a risk factor for an increased abdominoperineal resection rate?
### Response:
| LTME after TEM is a challenging procedure, with a significantly higher risk of APR compared to primary LTME. Future improvements in preoperative patient selection for TEM are needed to reduce this risk. |
### Instruction:
Is hepatocyte growth factor an attractive target for the treatment of pulmonary fibrosis?
### Response:
| HGF with its anti-fibrotic effect provides a promising new therapeutic approach by protecting lung from fibrotic remodeling and also promoting normal regeneration of lung. The development of HGF mimetics may provide a potential attractive therapy for treatment of this devastating and complex disease. |
### Instruction:
Is increased interleukin-23 associated with increased disease activity in patients with rheumatoid arthritis?
### Response:
| The levels of serum IL-23 in RA patients were higher than in healthy controls. Thus, elevated serum IL-23 levels may be useful markers to detect active RA. In addition, IL-23 is involved in disease progression and bony erosions in patients with RA. |
### Instruction:
Are brain natriuretic peptide and copeptin levels associated with cardiovascular disease in patients with chronic kidney disease?
### Response:
| BNP and copeptin appear to provide sensitive biological markers for the evaluation of atherosclerosis in non-dialysis patients with CKD. |
### Instruction:
Do dihydrotestosterone and bicalutamide affect periostin expression in androgen-dependent LNCaP prostate cancer cell lines?
### Response:
| We confirmed the role of POSTN in promoting cancer cell growth. Although POSTN transcription is not likely to be androgen-dependent, the fact that increased cell proliferation POSTN-mediated was impaired by BIC suggests an androgen modulation of POSTN interaction proteins. |
### Instruction:
Is prognosis deteriorating for upper tract urothelial cancer : data for England 1985-2010?
### Response:
| Despite sharing its risk factors with bladder cancer, current incidence and mortality trends for UTUC contrast with those in bladder cancer. Increasing use of cross-sectional imaging may explain some of the identified increased incidence. Higher incidence specifically in people >80 years, together with stage migration to more advanced cancers, are likely to have caused at least some of the observed increased mortality. Further study is required to answer the questions of whether there are other hitherto unidentified aetiological or prognostic factors; whether less aggressive treatment of UTUCs in the elderly is always justified; and whether the rising frequency of minimally invasive treatment means suboptimum oncological management. |
### Instruction:
Does expression of novel carotenoid biosynthesis genes from Enterococcus gilvus improve the multistress tolerance of Lactococcus lactis?
### Response:
| The expression of carotenoid biosynthesis genes from Ent. gilvus improves the multistress tolerance of L. lactis. |
### Instruction:
Does occlusal plane canting reduction accompany mandibular counterclockwise rotation in camouflaging treatment of hyperdivergent skeletal Class II malocclusion?
### Response:
| Increased OP canting with overerupted incisors is evident in the hyperdivergent skeletal Class II malocclusion. During the camouflaging treatment, reduction of OP canting could occur. It was accompanied by mandibular counterclockwise rotation and intrusion of the maxillary incisor. |
### Instruction:
Is subgenual anterior cingulate cortex activity covariation with cardiac vagal control altered in depression?
### Response:
| Findings in healthy volunteers suggest that sgACC participates in affective state shifting. The latter function appears to be altered in depressed individuals, and may have implications for the unvarying mood and vagal dysfunction associated with depression. |
### Instruction:
Are lA volumes and reservoir function associated with subclinical cerebrovascular disease : the CABL ( Cardiovascular Abnormalities and Brain Lesions ) study?
### Response:
| Greater LA volumes and reduced LA reservoir function are associated with subclinical cerebrovascular disease detected by brain magnetic resonance imaging in subjects without history of stroke. In particular, LAV(min) and LAEF are more strongly associated with SBI and WMHV than the more commonly measured LAVmax, and their relationship with subclinical brain lesions is independent of other cardiovascular risk factors. |
### Instruction:
Does a GPR18-based signalling system regulate IOP in murine eye?
### Response:
| We present evidence for a functional GPR18-based signalling system in the murine anterior eye, including receptors and ligands. GPR18 agonists, Abn-CBD and NAGly, reduce IOP independently of CB₁, CB₂ or GPR55. These findings suggest that GPR18 may serve as a desirable target for the development of novel ocular hypotensive medications. |
### Instruction:
Are serum levels of lipoprotein ( a ) and E-selectin reduced in rheumatoid arthritis patients treated with methotrexate or methotrexate in combination with TNF-α-inhibitor?
### Response:
| MTX or MTX combined with a TNFα-inhibitor appears to significantly reduce Lp(a). This finding indicate that s-Lp(a) might be related to systemic inflammation, or that the examined drugs might reduce s-Lp(a) by other mechanisms. Anti-inflammatory treatment might be a novel therapeutic option to decrease s-Lp(a). The associations between s-E-selectin and s-Lp(a) suggest an interaction between these factors, or a common cause. |
### Instruction:
Is spontaneous osteoarthritis in Str/ort mice unlikely due to greater vulnerability to mechanical trauma?
### Response:
| Genetic OA susceptibility in Str/ort mice is not apparently related to greater AC vulnerability to trauma, but joint loading modifies severity of natural OA lesions in the medial tibia. FE modelling suggests that thicker AC in Str/ort mice diminishes tissue stresses and protects against load-induced AC lesions in the LF but that this is unrelated to their genetic susceptibility to OA. |
### Instruction:
Is bRAF mutation positive papillary thyroid carcinoma less advanced when Hashimoto 's thyroiditis lymphocytic infiltration is present?
### Response:
| These results suggest that lymphocytic infiltration of HT is a protective factor against PTC progression, and it is independent of BRAF mutational status. |
### Instruction:
Does c609T Polymorphism of NADPH Quinone Oxidoreductase 1 correlate Clinical Hematological Toxicities in Lung Cancer Patients Treated with Amrubicin?
### Response:
| NQO1 C609T polymorphism had a tendency of correlation with the plasma concentrations of AMR-OH, and thereby had significant correlations with hematologic toxicities. |
### Instruction:
Does tracheal occlusion alter pulmonary circulation in the fetal lamb with normally developing lungs?
### Response:
| These data indicate that antenatal tracheal occlusion promotes active pulmonary vasodilation, which is partly blunted by the mechanical effects of elevation of the intraluminal pressure. |
### Instruction:
Does endostatin inhibit hypertrophic scarring in a rabbit ear model?
### Response:
| Our results from the rabbit ear hypertrophic scar model indicate that systemic application of endostatin could inhibit local hypertrophic scar formation, possibly through reducing scar vascularization and angiogenesis. Our results indicated that endostatin may promote the apoptosis of endothelial cells and block their release of platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF), thereby controlling collagen production by fibroblasts. Blood vessel-targeted treatment may be a promising strategy for scar therapy. |
### Instruction:
Do cirrhosis histology and Laennec staging system correlate with high portal pressure?
### Response:
| Histological subclassification of cirrhosis, collagen in the space of Disse and micronodularity are independent predictors of high portal pressure. The Laennec histological subclassification of cirrhosis correlates well with clinical severity of cirrhosis, and can provide useful prognostic information. |
### Instruction:
Is follicular variant of papillary thyroid carcinoma a unique clinical entity : a population-based study of 10,740 cases?
### Response:
| FV-PTC is a common variant of PTC. Its clinical behavior is unique and represents an intermediate entity with clinical features that are between C-PTC and FTC. Interestingly, despite the variations in clinical behavior, the long-term outcome of these patients remains excellent and similar to C-PTC. |
### Instruction:
Are ammonia and female sex hormones concentrations in human preovulatory follicular fluid directly related?
### Response:
| Ammonia production is not directly related to intrafollicular female sex hormones concentrations. The accumulation of ammonia is likely to account for the alkaline pH of the human preovulatory FF. |
### Instruction:
Does [ Hypoxia reduce the proliferation and occludin expression of primary sertoli cells ]?
### Response:
| Hypoxia suppresses the proliferation of Sertoli cells and reduces the expression of occludin. It could be inferred that hypoxia could damage the integrity of blood-testis barrier and spermatogenesis of the testis. |
### Instruction:
Are personality traits of the Five-Factor Model associated with work-related stress in special force police officers?
### Response:
| Personality factors may mitigate or increase the strain induced by environmental stressors. |
### Instruction:
Does swimming training prevent alterations in acetylcholinesterase and butyrylcholinesterase activities in hypertensive rats?
### Response:
| Exercise training was shown to prevent increased cholinesterase related to inflammatory processes in hypertensive rats, providing a new insight about protective exercise mechanisms to avoid hypertension-related inflammation. |
### Instruction:
Do protein markers predict body composition during growth hormone treatment in short prepubertal children?
### Response:
| Our results suggest that unique protein markers are associated with remodelling of different body compartments during GH treatment, which in the future might be useful to optimize GH treatment not only with regard to longitudinal growth. |
### Instruction:
Does expression quantitative trait loci analysis identify associations between genotype and gene expression in human intestine?
### Response:
| eQTL analysis of intestinal tissue supports findings that some eQTL remain stable across cell types, whereas others are specific to the sampled location. Our findings confirm and expand the number of known genotypes associated with expression and could help elucidate mechanisms of intestinal disease. |
### Instruction:
Are metabolic syndrome and central fat distribution related to lower serum osteocalcin concentrations?
### Response:
| This study showed that lower serum osteocalcin is associated with the presence of MS and that osteocalcin is inversely associated with BMI, WC, FPG and SBP, suggesting that osteocalcin plays a part in the development of MS. |
### Instruction:
Is revised central nervous system neuropenetration-effectiveness score associated with cognitive disorders in HIV-infected patients with controlled plasma viraemia?
### Response:
| A high prevalence of ANI was observed in virologically suppressed HIV-infected individuals. The revCPE rank showed improved association with neurocognitive dysfunction over the orCPE rank. Moreover, a relationship between cognitive impairment and adherence to antiretroviral therapy was found. |
### Instruction:
Does peripheral vasopressin but not oxytocin relate to severity of acute psychosis in women with acutely-ill untreated first-episode psychosis?
### Response:
| Results suggest an association of endogenous AVP with increased positive symptom severity and worse cognition in untreated female, but not male, schizophrenia patients. Findings support the role of neuroendocrine alterations in acute psychosis and the importance of examining sex-specific neuroendocrine alterations early in the course of schizophrenia. |
### Instruction:
Is elevated head circumference-to-height ratio an early and frequent feature in children with neurofibromatosis type 1?
### Response:
| Elevated HCHR is an early and frequent feature in NF1 children. Taking HCHR into account would facilitate the early detection of NF1. |
### Instruction:
Is serum N-terminal pro-brain natriuretic peptide level a significant prognostic factor in patients with severe sepsis among Southwest Chinese population?
### Response:
| Serum NT-proBNP is frequently increased in severe sepsis patients, and non-survivors have higher levels than survivors. High levels of admission NT-proBNP are associated with mortality. |
### Instruction:
Does total atherosclerotic burden by whole body magnetic resonance angiography predict major adverse cardiovascular events?
### Response:
| In a population-based sample of 70 year old men and women WBMRA, with TAS, predicted MACE independently of major cardiovascular risk factors. |
### Instruction:
Does interaction between conjunctival epithelial cells and mast cells induce CCL2 expression and piecemeal degranulation in mast cells?
### Response:
| Mast cell-conjunctival epithelial cell interaction induces CCL2 expression and subsequent PMD. |
### Instruction:
Does mammaPrint 70-gene profile quantify the likelihood of recurrence for early breast cancer?
### Response:
| The MammaPrint assay should help to determine which women with early breast cancer could be spared adjuvant chemotherapy. |
### Instruction:
Does cortico-limbic responsiveness to high-calorie food images predict weight status among women?
### Response:
| Findings suggest that long-term weight status is related to visual responsiveness to calorie-dense food imagery among women. |
### Instruction:
Is the beneficial effect of icaritin on osteoporotic bone dependent on the treatment initiation timing in adult ovariectomized rats?
### Response:
| ICT can exert anabolic and anti-resorptive effect on osteoporotic bone. The beneficial effect of ICT treatment is dependent on the intervention timing in established osteoporosis induced by estrogen depletion. |
### Instruction:
Does high-magnification sperm selection decrease the aneuploidy rate in patients who are heterozygous for reciprocal translocations?
### Response:
| For patients who are heterozygous for reciprocal translocations, MSOME does not improve the selection of euploid spermatozoa. |
### Instruction:
Is the right posterior bile duct anatomy of the donor important in biliary complications of the recipients after living-donor liver transplantation?
### Response:
| The anatomy of the RPBD of the donor influenced the biliary outcome in the recipients. A short RBD and a long caudal segment of the RPBD of the donor were significant risk factors for biliary complications in LDLT. |
### Instruction:
Do common underlying diseases contribute in determining the causes of sudden unexplained death?
### Response:
| Common underlying diseases make no obvious contributions to SUD and are not useful in diagnosing the underlying reasons for death. |
### Instruction:
Do naïve rat umbilical cord matrix stem cells significantly attenuate mammary tumor growth through modulation of endogenous immune responses?
### Response:
| These results suggest that naïve rat UCMSCs attenuated mammary tumor growth at least in part by enhancing host anti-tumor immune responses. Naïve UCMSCs can be used as powerful therapeutic cells for breast cancer treatment, and monocyte chemotactic protein-1 may be a key molecule to enhance the effect of UCMSCs at the tumor site. |
### Instruction:
Is umbilication a strong predictor of high-grade cervical intraepithelial neoplasia?
### Response:
| Umbilication is an age-independent colposcopic feature with very high specificity for predicting CIN 2/3. |
### Instruction:
Is eating location associated with the nutritional quality of the diet in Norwegian adults?
### Response:
| Dinner eating location was significantly associated with the nutritional quality of the diet, both for the specific dinner meal and for whole-day intake. Our data generally point to healthier dinners being consumed at home. SOH-eaters had a less favourable dietary intake than NSOH-eaters. |
### Instruction:
Does a genetic screen identify interferon-α effector genes required to suppress hepatitis C virus replication?
### Response:
| We performed a whole-genome loss-of-function screen to identify genes that mediate the effects of IFNα against human pathogenic viruses. We found that IFNα restricts HCV via actions of general and specific IEGs. |
### Instruction:
Does n-acetyl-cysteine prevent pyramidal cell disarray and reelin-immunoreactive neuron deficiency in CA3 after prenatal immune challenge in rats?
### Response:
| Hippocampal cytoarchitectural alterations and reelin deficiency may be involved in the development of remote cognitive impairments in this model. The antioxidant NAC is an efficient neuroprotective drug that underlines the role of oxidative stress in prenatal infection and associated neurodevelopmental damage. |
### Instruction:
Does cortical somatosensory processing measured by magnetoencephalography predict neurodevelopment in extremely low-gestational-age infants?
### Response:
| Abnormal SII responses at term predict adverse neuromotor development at 2 y of corrected age. This adverse development may not be foreseen with conventional neuroimaging methods, suggesting a role for evaluating SII responses in the developmental risk assessment of ELGA infants. |
### Instruction:
Does knockdown of PRAS40 inhibit insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells?
### Response:
| Inhibition of insulin action in PRAS40-KD myotubes was found to associate with IRS1 degradation promoted by increased proteasome activity rather than hyperactivation of the p70S6K-negative-feedback loop. These findings identify PRAS40 as a modulator of insulin action. |
### Instruction:
Does sCIRehab used practice-based evidence methodology to associate patient and treatment characteristics with outcomes?
### Response:
| The application of PBE methodology in the SCIRehab study provided extensive information about the process of inpatient SCI rehabilitation. While patient demographic and injury characteristics explain substantial variation in rehabilitation outcomes, particularly functional outcomes, significant relations also were found between the type and quantity of treatment interventions delivered by each rehabilitation discipline and a broad range of outcomes. |
### Instruction:
Do noninvasive fibrosis indices predict intrahepatic distant recurrence of hepatitis B-related hepatocellular carcinoma following radiofrequency ablation?
### Response:
| High levels of AFP and API predict IDR of HBV-related HCC after RFA. Therefore, noninvasive fibrosis indices could play an important role in predicting IDR of HCC following percutaneous ablation. |
### Instruction:
Does soSoSo or its active ingredient chrysophanol regulate production of inflammatory cytokines & adipokine in both macrophages & adipocytes?
### Response:
| These results suggest a potential of SoSoSo or chrysophanol as a source of anti-inflammatory agent for obesity. Further in vivo studies would be required to confirm these findings. |
### Instruction:
Is selenium inversely associated with interleukin-6 in the elderly?
### Response:
| Serum selenium was inversely associated with inflammatory cytokine interleukin-6 among elderly living in long-term care facilities in Taiwan. Monitoring serum selenium should be considered in these institutionalized elderly. |
### Instruction:
Is non-melanoma skin cancer of the auricle treated according to national guidelines?
### Response:
| BCC and SCC were observed equally on the auricle in our study. This confirms that BCC and SCC of the auricle are represented differently than on the other parts of the body. The national and international guidelines on NMSCs are sufficiently followed with regard to treatment of choice and excision margins; however, the follow-up should be more precise. |
### Instruction:
Are admission criteria to the Danish Brain Cancer Program moderately associated with magnetic resonance imaging findings?
### Response:
| Fewer tumours than expected were found. Significantly fewer pathologies were found in the group with monosymptomatic headache than in the remaining groups. |
### Instruction:
Are feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1 involved in arsenite-induced cell malignant transformation?
### Response:
| The results indicate that miR-21 is both a target and a regulator of ERK/NF-κB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells. |
### Instruction:
Does intranasal infection with Chlamydia abortus induce dose-dependent latency and abortion in sheep?
### Response:
| The results show that intranasal administration of non-pregnant sheep with a low/medium dose of C. abortus results in a latent infection that leads in a subsequent pregnancy to infection of the placenta and abortion. In contrast a high dose stimulates protective immunity, resulting in a much lower abortion rate. This model will be useful in understanding the mechanisms of infection underlying latency and onset of disease, as well as in the development of novel therapeutics and vaccines for controlling infection. |
### Instruction:
Does thrombus-targeted nanocarrier attenuate bleeding complications associated with conventional thrombolytic therapy?
### Response:
| tPA-loaded homing-peptide-grafted-liposomes demonstrate enhanced thrombolytic activity with reduced hemorrhagic risk. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.