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### Instruction:
Does downregulation of N-cadherin in the neointima stimulate migration of smooth muscle cells by RhoA deactivation?
### Response:
| These results indicate that the regulation of haSMC attachment by N-cadherins is essential for haSMC migration. Modification of N-cadherin expression and activity induces RhoA signaling with relevance for the reorganization of the actin cytoskeleton. |
### Instruction:
Does cyclooxygenase-2 inhibitor treatment improve left ventricular function and mortality in a murine model of doxorubicin-induced heart failure?
### Response:
| COX-2 inhibitors can attenuate the progression of heart failure in a murine model of doxorubicin-induced heart failure. |
### Instruction:
Are pregnancy-associated plasma protein A and its endogenous inhibitor , the proform of eosinophil major basic protein ( proMBP ) , related to complex stenosis morphology in patients with stable angina pectoris?
### Response:
| In patients with stable angina, PAPP-A and PAPP-A/proMBP ratio are associated with angiographic plaque complexity. |
### Instruction:
Does c1-inhibitor reduce hepatic leukocyte-endothelial interaction and the expression of VCAM-1 in LPS-induced sepsis in the rat?
### Response:
| Our results indicate that even upon delayed treatment hepatic adhesion molecule expression and LEI can be reduced by C1-INH. The multifunctional regulator may reduce hepatic microcirculatory disturbances during sepsis under clinical conditions. |
### Instruction:
Do hepatitis B genotypes correlate with tumor recurrence after curative resection of hepatocellular carcinoma?
### Response:
| Our data suggest that patients with HCC with genotype C have a greater tumor recurrence rate after curative resection of HCC compared with those with genotype B. Prolonged follow-up is needed to clarify the impact of HBV genotype on postoperative outcome. |
### Instruction:
Does variable corneal compensation improve discrimination between normal and glaucomatous eyes with the scanning laser polarimeter?
### Response:
| Individual correction for corneal birefringence with the VCC significantly improved the ability of the SLP to distinguish between normal and glaucomatous eyes and enabled detection of patients with early glaucoma. |
### Instruction:
Is indian Agarwal megalencephalic leukodystrophy with cysts caused by a common MLC1 mutation?
### Response:
| Indian patients with megalencephaly and MRI changes that show extensive white matter changes with temporal cysts should raise suspicion for MLC. Members of the Agarwal ethnic group affected with the disorder present with a mildly progressive course and show a common mutation (320insC) in the MLC1 gene, suggesting a founder effect. |
### Instruction:
Is chronic low back pain-associated paraspinal muscle dysfunction the result of a constitutionally determined `` adverse '' fiber-type composition?
### Response:
| In the patients with chronic low back pain tested, their associated paraspinal muscle dysfunction was not the result of a constitutionally determined "adverse" fiber type composition. |
### Instruction:
Do plasma adenosine concentrations increase in women with hyperemesis gravidarum?
### Response:
| Adenosine is an established suppressor of excessive sympathetic nerves activation and cytokine production, so the increase in plasma adenosine in hyperemesis gravidarum might serve to counteract further progression of hyperemesis gravidarum. |
### Instruction:
Is regulation of COX-2 protein expression by Akt in endometrial cancer cells mediated through NF-kappaB/IkappaB pathway?
### Response:
| These results demonstrate that Akt signals through NF-kappaB/IkappaB pathway to induce COX-2 expression in mutated PTEN endometrial cancer cells. |
### Instruction:
Is repaglinide more efficient than glimepiride on insulin secretion and post-prandial glucose excursions in patients with type 2 diabetes . A short term study?
### Response:
| Our study demonstrates that R is more efficient that G on improving glucose- and meal- induced insulin secretion as well as on controlling for postprandial glucose excursion. |
### Instruction:
Is early referral to a nephrologist associated with better outcomes in type 2 diabetes patients with end-stage renal disease?
### Response:
| During the course of chronic renal failure in type 2 diabetes patients, early implementation of nephrological well-established guIdelines is associated with better outcome after starting RRT. |
### Instruction:
Is hepatitis C virus independently associated with increased insulin resistance after liver transplantation?
### Response:
| HCV is independently associated with increased IR after OLT. These findings provide a possible pathogenetic basis for the association of DM with HCV. |
### Instruction:
Does presentation of donor major histocompatibility complex class II antigens by dna vaccination prolong heart allograft survival?
### Response:
| After transplantation the anti-donor cellular response was significantly decreased in vaccinated rats. This was accompanied by a significant reduction in interferon-gamma mRNA expression in the grafted hearts and T helper 1-type alloantibody production, indicating that the vaccination modifies the alloresponse against the grafts. |
### Instruction:
Does low molecular weight dextran sulfate prevent the instant blood-mediated inflammatory reaction induced by adult porcine islets?
### Response:
| Given that LMW-DS has been used in clinical studies without serious adverse reactions, it has potential as a drug candidate that can control the strong innate immune response induced by pig islets when transplanted through the portal vein. |
### Instruction:
Does resveratrol suppress the angiogenesis and tumor growth of gliomas in rats?
### Response:
| Resveratrol caused significant glioma cell cytotoxicity and apoptosis, exerted antitumor effects on the s.c. and intracerebral gliomas, and inhibited angiogenesis in s.c. gliomas. Thus, resveratrol might be considered a possible treatment strategy for gliomas. |
### Instruction:
Is exercise release of cardiac natriuretic peptides markedly enhanced when patients with coronary artery disease are treated medically by beta-blockers?
### Response:
| Patients with chronic CAD exhibit much higher exercise releases of ANP and BNP when they are treated with beta-blockers. This enhanced secretion of potent vasodilating and natriuretic agents constitutes an original therapeutic mechanism for further protecting diseased hearts against stress. |
### Instruction:
Is noninvasive estimation of left ventricular filling pressure by E/e ' a powerful predictor of survival after acute myocardial infarction?
### Response:
| E/e' is a powerful predictor of survival after acute MI. An E/e' ratio >15 is superior, in this respect, to other clinical or echocardiographic features. Furthermore, it provides prognostic information incremental to these parameters. |
### Instruction:
Does prevention of ischemic mitral regurgitation influence the outcome of remodeling after posterolateral myocardial infarction?
### Response:
| Prophylactic ventricular restraint reduces infarct expansion, attenuates adverse remodeling, and reduces IMR severity. Prevention of IMR by prophylactic ring annuloplasty does not influence remodeling. Ischemic mitral regurgitation is a consequence, not a cause, of postinfarction remodeling; infarct expansion is the more important therapeutic target. |
### Instruction:
Are chromosomal amplifications , 3q gain and deletions of 2q33-q37 the frequent genetic changes in cervical carcinoma?
### Response:
| This study demonstrated that 2q33-q37 deletions, 3q gains and chromosomal amplifications as characteristic changes in invasive CC. These genetic alterations will aid in the identification of novel tumor suppressor gene(s) at 2q33-q37 and oncogenes at amplified chromosomal sites. Molecular characterization of these chromosomal changes utilizing the current genomic technologies will provide new insights into the biology and clinical behavior of CC. |
### Instruction:
Do matrix metalloproteinase-2 and matrix metalloproteinase-9 expressions correlate with the recurrence of intracranial meningiomas?
### Response:
| Our study indicated that MMP-2 and MMP-9 expressions are prognostic factors predicting the recurrence of meningioma, independent of proliferative potential. |
### Instruction:
Is aldosterone resistance in kidney transplantation in part induced by a down-regulation of mineralocorticoid receptor expression?
### Response:
| The present data demonstrate that hyperkalemia and metabolic acidosis following CsA treatment in kidney transplantation might be associated with a down-regulation of MR expression on peripheral leukocytes. Electrolyte imbalance is reversible on application of fludrocortisone. This observation supports fludrocortisone treatment in transplant patients with severe electrolyte disturbances. |
### Instruction:
Is cardiovascular disease in renal allograft recipients associated with elevated sialic acid or markers of inflammation?
### Response:
| This study suggests that inflammation is associated with a higher prevalence of cardiovascular disease in patients with renal allografts. The measurement of sialic acid as a risk factor may be superior to that of CRP in this group as its concentration is independent of renal function. |
### Instruction:
Do the significance of contrast blush on computed tomography in children with splenic injuries?
### Response:
| Although associated with higher grades of injury, the blush sign did not mandate embolization or surgical intervention in children with blunt splenic trauma in this series. Severe splenic injuries with a blush sign on the initial CT scan may be successfully treated nonoperatively when using an established treatment protocol. Management should be based primarily on physiological response to injury rather than the radiologic features of the injury. |
### Instruction:
Is osteopontin but not osteonectin messenger RNA expression a prognostic marker in curatively resected non-small cell lung cancer?
### Response:
| The large increase in OPN expression in tumors compared with normal tissue and its association with survival suggest a role for OPN in lung tumorigenesis. |
### Instruction:
Is patient satisfaction rated higher by radiation oncology outpatients receiving nutrition intervention compared with usual care?
### Response:
| These data suggest that patients receiving NI perceive nutrition as being beneficial and of higher importance to their health than those receiving UC. This may lead to increased compliance with the nutrition prescription and help explain the better outcomes observed in the NI group compared with the UC group. Patient satisfaction with nutrition services should be conducted regularly to act as a quality-control measure and target areas for improvement. |
### Instruction:
Is prolonged bleeding time induced by anticoagulant glycosaminoglycans in dogs associated with the inhibition of thrombin-induced platelet aggregation?
### Response:
| These results suggest that the prolongation of bleeding time caused by GAGs are associated with the inhibition of thrombin-induced platelet aggregation, and DHG may cause less bleeding than UFH and LMWH because of its different thrombin inhibition mechanism in platelet-rich plasma (PRP). |
### Instruction:
Is the E-selectin S128R polymorphism a risk factor for coronary artery disease in patients with diabetes mellitus type 2?
### Response:
| In subjects suffering from diabetes mellitus type 2 the E-selectin S128R polymorphism is not associated with coronary artery disease nor with an increased risk for myocardial infarction. Thus, screening for this polymorphism is not indicated for risk assessment of CAD in patients with diabetes mellitus. |
### Instruction:
Does the HMG-CoA reductase inhibitor atorvastatin prevent atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis model?
### Response:
| Atorvastatin can prevent maintenance of AF by inhibiting inflammation in the canine sterile pericarditis model. Atorvastatin may thus be a novel therapeutic agent for AF. |
### Instruction:
Is swelling-activated chloride current activated in guinea pig cardiomyocytes from endotoxic shock?
### Response:
| We have shown for the first time that ICl,swell activates in guinea pig heart in endotoxic shock. The change in this membrane current, together with the activation of ATP-sensitive K+ current, contributes to the electrophysiological derangement in endotoxic shock. |
### Instruction:
Does interaction of angiotensin II with the angiotensin type 2 receptor inhibit the cardiac transient outward potassium current?
### Response:
| These results indicate that AngII activates PP2A through the stimulation of the AT2R, resulting in a decrease of the Ito amplitude. |
### Instruction:
Does postconditioning attenuate myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion?
### Response:
| (1) Post-con at onset of R reduces myocardial injury; (2) cardioprotection may be mediated, in part, by inhibiting oxidant generation and oxidant mediated injury; (3) the first minute of R in the rat model is critical to cardioprotection by Post-con; and (4) cardioprotection by Post-con may be independent of neutrophil accumulation in AAR. *p<0.05 Post-con vs. Control. |
### Instruction:
Do human mesenchymal stem cells form Purkinje fibers in fetal sheep heart?
### Response:
| Human mesenchymal stem cells preferentially engraft at high levels in the ventricular conduction system during fetal development in sheep. These findings raise the possibility that stem cells contribute to normal development of the fetal heart. |
### Instruction:
Does atorvastatin affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 weeks in patients with acute coronary syndromes?
### Response:
| Atorvastatin does not affect the antiplatelet potency of clopidogrel when coadministered for 5 weeks in ACS patients. |
### Instruction:
Are hLA-DQA1 and DQB1 alleles associated with genetic susceptibility to psoriasis vulgaris in Chinese Han?
### Response:
| HLA-DQA1*0104 and DQA1*0201 alleles may be psoriasis susceptibility genes or may be in close linkage with the susceptibility genes. The HLA-DQA1*0501 allele seems to have a protective effect against the development of psoriasis vulgaris in Chinese Han. There may be a difference in genetic background between psoriasis patients with and without a family history of psoriasis. |
### Instruction:
Is hypercholesterolemia common after pediatric heart transplantation : initial experience with pravastatin?
### Response:
| Hypercholesterolemia is prevalent in pediatric cardiac transplant recipients. Pravastatin therapy is effective in decreasing TC and LDL levels, seems to be safe, and is tolerated well. Further studies are necessary to determine whether pravastatin treatment is beneficial in decreasing CAV. |
### Instruction:
Does polymorphism of interleukin-1beta affect the eradication rates of Helicobacter pylori by triple therapy?
### Response:
| IL-1beta-511 polymorphism is one of the determinants of successful eradication of H. pylori using triple therapy with a PPI, amoxicillin, and clarithromycin, together with CYP2C19 genotype and bacterial resistance to clarithromycin. |
### Instruction:
Does inhibition of platelet aggregation by aspirin progressively decrease in long-term treated patients?
### Response:
| The study demonstrates that a long-term treatment with aspirin is associated with a progressive reduction in platelet sensitivity to this drug. |
### Instruction:
Is downregulation of retinoic acid receptor-beta ( 2 ) expression linked to aberrant methylation in esophageal squamous cell carcinoma cell lines?
### Response:
| The methylation of the 5' region may play an important role in the downregulation of RARbeta(2) in some ESCC cell lines, suggesting that multiple mechanisms contribute to the loss of RARbeta(2) expression in ESCC cell lines. This study may have clinical applications for treatment and prevention of ESCC. |
### Instruction:
Does disruption of the Zymomonas mobilis extracellular sucrase gene ( sacC ) improve levan production?
### Response:
| Zymomonas mobilis sacC gene encoding an extracellular sucrase was inactivated by gene disruption. This sacC mutant strain produced higher level of levan in sucrose medium because of the improved levansucrase (SacB) than the parent strain. |
### Instruction:
Does pirfenidone inhibit obliterative airway disease in a murine heterotopic tracheal transplant model?
### Response:
| Our results demonstrate a delay of onset or abrogation of OAD when pirfenidone is administered in the early posttransplantation period. These findings suggest that pirfenidone is a candidate drug to be evaluated for prevention of the fibrotic changes seen in OB in human recipients of lung transplants. |
### Instruction:
Do acetylcholinesterase alterations reveal the fitness cost of mutations conferring insecticide resistance?
### Response:
| Our findings suggest that the alteration of activity and stability of acetylcholinesterase are at the origin of the fitness cost associated with mutations providing resistance. Magnitude of the alterations was related to the allelic frequency in Drosophila populations suggesting that the fitness cost is the main driving force for the maintenance of resistant alleles in insecticide free conditions. |
### Instruction:
Does cGH analysis show genetic similarities and differences in atypical fibroxanthoma and undifferentiated high grade pleomorphic sarcoma?
### Response:
| Despite their very similar histology, AFX and UpS show clear differences in their genetic alterations. This might contribute to the different biological behavior of the two tumors. On the other hand the similarities in genetic alterations on chromosomes 9p and 13q might suggest a common pathogenetic pathway. |
### Instruction:
Does ultrasound perfusion imaging in acute middle cerebral artery infarction predict outcome?
### Response:
| In the early phase of acute ischemic stroke, BHI after SonoVue bolus injection is a useful ultrasound tool for analyzing cerebral perfusion deficits at the patient's bedside. BHI data correlate with the definite area of infarction and outcome after 4 months. |
### Instruction:
Does functional liver recovery parallel autologous gut salvage in short bowel syndrome?
### Response:
| This preliminary experience suggests that PN-dependent patients with advanced liver dysfunction in the setting of the short bowel syndrome may, in some instances, experience functional and biochemical liver recovery. The latter appears to parallel autologous gut salvage in most cases. As a corollary, the authors believe that even advanced degrees of liver dysfunction should not preclude attempts at autologous gut salvage in very carefully selected patients. Such a policy of "aggressive conservatism" may help avoid the need for liver/intestinal transplantation in some patients who appear to be not responding to PN. |
### Instruction:
Do proinflammatory cytokines increase iron uptake into human monocytes and synovial fibroblasts from patients with rheumatoid arthritis?
### Response:
| Proinflammatory cytokines produced in human rheumatoid arthritis synovium and synovial fluid may contribute to the accumulation of iron that occurs in rheumatoid arthritis synovium which may lead to damage to synovial fibroblasts, macrophages and lymphocytes. |
### Instruction:
Are spikes on the postoperative EEG related to preoperative spike frequency and postoperative seizures?
### Response:
| We hypothesize that two factors independently influence the presence of postoperative spikes: chronic interictal disturbance (represented as preoperative spike frequency) and the acute (postoperative) seizures. Our study confirmed that persistent postoperative IED had a prognostic value regarding the outcome of the epilepsy surgery. |
### Instruction:
Does yogurt feeding inhibit promotion and progression of experimental colorectal cancer?
### Response:
| These results show that yogurt inhibited tumor progression and promotion by modulating the immune response and stimulating cellular apoptosis. |
### Instruction:
Does activation of protease-activated receptor-2 lead to inhibition of osteoclast differentiation?
### Response:
| These observations indicate that PAR-2 activation inhibits osteoclast differentiation by acting on cells of the osteoblast lineage to modulate multiple mediators of the effects of PTH, 1,25(OH)2D3, and IL-11. Therefore, the role of PAR-2 in bone may be to protect it from uncontrolled resorption by limiting levels of osteoclast differentiation. |
### Instruction:
Does diet rich in saturated fat decrease the ratio of thromboxane/prostacyclin in healthy men?
### Response:
| Diet rich in SFA from animal sources may influence TXA2 formation via effect on tissue proportion of 20:4n-6. |
### Instruction:
Does intestinal expression of mutant and wild-type progastrin significantly increase colon carcinogenesis in response to azoxymethane in transgenic mice?
### Response:
| The results of the current study suggest that at concentrations (approximately 1.0 nM) far lower than the ones observed in hGAS mice, PG functions as an equally potent cocarcinogen and significantly increases the risk of colon carcinogenesis in response to AOM. Thus, PG may represent a clinically relevant target molecule in patients with hypergastrinemia or colon carcinoma. |
### Instruction:
Does inhibition of gamma-glutamyl transpeptidase activity decrease intracellular cysteine levels in cervical carcinoma?
### Response:
| In tumours and cell lines with elevated levels of gamma-GT activity, inhibition of this enzyme led to decreases of cysteine levels. |
### Instruction:
Is cytotoxicity of the organic ruthenium anticancer drug Nami-A correlated with DNA binding in four different human tumor cell lines?
### Response:
| There was no saturation of the uptake and DNA binding capacity of either Nami-A or cisplatin. Furthermore, the low binding of Nami-A to cellular DNA cannot simply be explained by a lower capacity to bind to DNA, because the absolute level of binding in vitro to calf thymus DNA was the same for Nami-A and cisplatin. Finally, the lower cytotoxicity of Nami-A on a molar basis than that of cisplatin can at least partly be explained by its reduced reactivity to DNA in intact cells. |
### Instruction:
Is hip strategy for balance control in quiet standing reduced in people with low back pain?
### Response:
| The inability to control a hip strategy indicates a deficit of postural control and is hypothesized to result from altered muscle control and proprioceptive impairment. |
### Instruction:
Does low mechanical index contrast-enhanced ultrasound better reflect high arterial perfusion of liver metastases than arterial phase computed tomography?
### Response:
| Contrast-enhanced CT may not be able to visualize short-lasting but large differences of the arterial perfusion of liver metastases, as does contrast-enhanced low-MI ultrasound. This offers new methods for their characterization and for monitoring of therapeutic effects. |
### Instruction:
Are respiratory changes in inferior vena cava diameter helpful in predicting fluid responsiveness in ventilated septic patients?
### Response:
| Our study suggests that respiratory change in IVC diameter is an accurate predictor of fluid responsiveness in septic patients. |
### Instruction:
Do myocardial inflammatory responses to sepsis complicated by previous burn injury?
### Response:
| A previous burn injury alters myocardial inflammatory responses, predisposing the burn-injured subject to exaggerated inflammation, which correlates with greater myocardial dysfunction. |
### Instruction:
Is lumiracoxib effective in the treatment of osteoarthritis of the knee : a 13 week , randomised , double blind study versus placebo and celecoxib?
### Response:
| Lumiracoxib demonstrated significant improvement in OA pain intensity, patients global assessment of disease activity, and the WOMAC pain subscale and total scores compared with placebo. Lumiracoxib was well tolerated in this study, with overall tolerability similar to that of placebo and celecoxib. |
### Instruction:
Is vascular endothelial zinc finger 1 involved in the regulation of angiogenesis : possible contribution of stathmin/OP18 as a downstream target gene?
### Response:
| These results suggest that Vezf1 is involved in the regulation of angiogenesis, at least in part, through the expression of stathmin/OP18 in ECs. |
### Instruction:
Does acanthoic acid inhibit IL-8 production via MAPKs and NF-kappaB in a TNF-alpha-stimulated human intestinal epithelial cell line?
### Response:
| Acanthoic acid might inhibit TNF-alpha-mediated IL-8 production by blocking in both the MAPKs and NF-kappaB pathways in HT29 cells. |
### Instruction:
Does local delivery of marrow-derived stromal cells augment collateral perfusion through paracrine mechanisms?
### Response:
| MSCs secrete a wide array of arteriogenic cytokines. MSCs can contribute to collateral remodeling through paracrine mechanisms. |
### Instruction:
Does new approach towards laboratory diagnosis of isolated sulphite oxidase deficiency?
### Response:
| We found total homocysteine concentrations below the limit of quantification (<1 micromol/L) in all samples of patients with sulphite oxidase deficiency studied in this regard and that the proportion of S-sulphonated transthyretin is clearly increased in such samples. Our observations suggest additional tools for selective screening and diagnostic work-up of patients suspected of having sulphite oxidase deficiency. |
### Instruction:
Do intraoperative neurophysiologic discovery of uncrossed sensory and motor pathways in a patient with horizontal gaze palsy and scoliosis?
### Response:
| The results indicate uncrossed dorsal column-medial lemniscal and corticospinal pathways due to brain-stem malformation with absent internal arcuate and pyramidal decussations. |
### Instruction:
Does overexpression of uncoupling protein 2 in THP1 monocytes inhibit beta2 integrin-mediated firm adhesion and transendothelial migration?
### Response:
| Mitochondrial UCP2 in circulating monocytes may prevent excessive accumulation of monocytes/macrophages in the arterial wall, thereby reducing atherosclerotic plaque formation. |
### Instruction:
Does hearing result in stapes surgery using two different prosthesis?
### Response:
| Our data shows that titanium piston is a as good as fluoroplastic piston in stapes surgery for otosclerosis. |
### Instruction:
Do [ Determination of danshensu in rat serum after oral administer compound Salvia recipe ]?
### Response:
| Danshensu can be absorbed into blood after ig compound Salvia recipe. |
### Instruction:
Is osteopontin up-regulated in human decidual stromal cells?
### Response:
| Osteopontin is expressed at high concentrations in secretory endometrium in epithelial cells and in decidua in stromal cells. Decidual stromal expression of osteopontin is up-regulated by decidualization. |
### Instruction:
Do tSH receptor antibodies alter the function of gonadotropin receptors stably expressed in eukaryotic cells?
### Response:
| Our results confirm the notion of the organ-specific nature of the TSHr antibodies. |
### Instruction:
Do green tea polyphenols inhibit advanced glycation end product-induced rat vascular smooth muscle cell proliferation?
### Response:
| GTP can inhibit the AGE-induced proliferation and p44/42 MAPK expression of rat VSMCs. |
### Instruction:
Are trabecular bone mass and bone formation preserved after limb immobilisation in p53 null mice?
### Response:
| Disruption of the p53 gene preserves trabecular bone mass and leads to bone formation after limb immobilisation. |
### Instruction:
Does fibroblast growth factor 10 ( Fgf10 ) invalidation result in anorectal malformation in mice?
### Response:
| Fgf10 is expressed in the rectum at the time when anorectal continuity is established, indicating a role in normal anorectal development. Fgf10 invalidation (Fgf10-/- mutant) results in a genetically reproducible anorectal malformation phenotype. Fgf10 function is critical for normal anorectal development. |
### Instruction:
Is human hair greying linked to a specific depletion of hair follicle melanocytes affecting both the bulb and the outer root sheath?
### Response:
| Thus, hair greying appears to be a consequence of an overall and specific depletion of bulb and ORS melanocytes of human hair. |
### Instruction:
Do human adipose tissue-derived cells delay re-epithelialization in comparison with skin fibroblasts in organotypic skin culture?
### Response:
| The possibility of generating HSEs with different cell types represents an attractive approach for in vitro studies focusing on the mechanism of wound healing. |
### Instruction:
Is scintigraphic sign of functional biliary obstruction pathognomic for sphincter of Oddi dysfunction?
### Response:
| In conclusion, glyceryl trinitrate-augmented QHBS is a specific method in the diagnosis of SOD, proving the functional reversibility of the biliary obstruction. |
### Instruction:
Are cardiovascular risk in healthy men and markers of oxidative stress in diabetic men associated with common variation in the gene for uncoupling protein 2?
### Response:
| This study provides the first in vivo evidence of a role for UCP2 in modifying oxidative stress and CHD risk in humans. |
### Instruction:
Does smoking cessation increase gingival blood flow and gingival crevicular fluid?
### Response:
| The results show that the gingival microcirculation recovers to normal in the early stages of smoking cessation, which could activate the gingival tissues metabolism/remodeling, and contribute to periodontal health. |
### Instruction:
Does the presence of emphysema affect the systemic bioactivity of inhaled fluticasone in severe chronic obstructive pulmonary disease?
### Response:
| Severe COPD patients who are receiving high dose FP are susceptible to the development of systemic adverse effects, irrespective of the presence of emphysema. |
### Instruction:
Does raloxifene therapy affect uterine blood flow in postmenopausal women : a transvaginal Doppler study?
### Response:
| In the group studied here, raloxifene treatment at the dose of 60 mg per day for 6 months did not induce significant changes in endometrial thickness, uterine volume or uterine artery perfusion, confirming that short-term raloxifene treatment does not affect the uterus of postmenopausal women. |
### Instruction:
Is human PRMT5 expression enhanced during in vitro tubule formation and after in vivo ischemic injury in renal epithelial cells?
### Response:
| The role of PRMT5 in the regulation of mitosis, its induction in renal epithelial cells undergoing tubule formation in vitro and its expression in the tubules of the kidneys subjected to IRI suggest that it functions in the regulation of cell growth and differentiation during tubule formation and regeneration. |
### Instruction:
Does aldosterone antagonism ameliorate proteinuria and nephrosclerosis independent of glomerular dynamics in L-NAME/SHR model?
### Response:
| The aldosterone antagonist eplerenone significantly ameliorated proteinuria and nephrosclerosis in the L-NAME/SHR model, independent of hemodynamic effects. |
### Instruction:
Does re-hospitalization after diagnosis of diabetes vary by gender and socioeconomic status in urban African-American and Latino young people?
### Response:
| About 60% of respondents were re-hospitalized at least once for diabetes-related reasons (n = 128). Half of those questioned had Medicaid or no health insurance at all; 23% fit criteria for a non-autoimmune, type 2 diabetic phenotype. Those who avoided re-hospitalization were more likely to have been seen initially at a tertiary care facility, to have private health insurance, and to be males. They had, on average, 2 yr shorter duration of diabetes at the time of interview. Risk for re-hospitalization was not associated with age at diagnosis, ethnicity, diabetic phenotype, or source of care during the past year. In multivariate analysis, predictors of re-hospitalization were gender [odds ratio (OR) 1.98 for females vs. males (95% confidence interval (CI) = 1.05-3.72)], duration of diabetes [OR = 1.46 per yr (95% CI = 1.36-1.57)], initial ascertainment at a community hospital [OR = 5.44 vs. tertiary care facility (95% CI = 2.61-11.29)] and having Medicaid or no insurance [OR = 2.73 (95% CI = 1.42-5.24)], compared with those with another type of health insurance. There is a high risk of re-hospitalization after the initial diagnosis of diabetes among insulin-treated minority children, particularly the uninsured and those on Medicaid, in part related to duration of disease and where the initial treatment occurred. |
### Instruction:
Does desflurane result in higher cerebral blood flow than sevoflurane or isoflurane at hypocapnia in pigs?
### Response:
| More cerebral vasodilation at hypocapnia with high doses of desflurane than with sevoflurane or isoflurane indicates that desflurane might be less suitable for neuroanaesthesia than sevoflurane and isoflurane. |
### Instruction:
Does [ Type of electric currents used for standard endoscopic sphincterotomy determine the type of complications ]?
### Response:
| Development of complications after standard EST such as hyperamylasemia, clinical pancreatitis, and bleeding may not depend on the electric current used. |
### Instruction:
Is frequency of rib and sternum fractures associated with out-of-hospital cardiopulmonary resuscitation underestimated by conventional chest X-ray?
### Response:
| The findings of this study indicate that fractures associated with CPR are underreported in conventional radiographic investigations. No major bleeding complications related to CPR-associated fractures was detected. |
### Instruction:
Does a peptide that share similarity with bacterial antigens reverses thrombogenic properties of antiphospholipid antibodies in vivo?
### Response:
| The data indicates that a synthetic peptide that shares similarity with common bacterial antigens and with regions of beta2GPI is capable to inhibit thrombogenic properties of aPL in mice. This may have important implications in designing new modalities of prevention and/or treatment of thrombosis in APS. |
### Instruction:
Does gene expression profiling identify platelet-derived growth factor as a diagnostic molecular marker for papillary thyroid carcinoma?
### Response:
| Platelet-derived growth factor may be a potential biomarker for PTC and follicular carcinoma. Expression profile analysis using a microarray followed by immunohistochemical study can be used to facilitate the development of molecular biomarkers for cancer. |
### Instruction:
Do a longitudinal analysis of discrete negative emotions and health-services use in elderly individuals?
### Response:
| The interactions indicate the importance of negative emotions and the larger social and developmental context in health care services use among elderly individuals. |
### Instruction:
Are functional properties of the surface of the vermilion border of the lips distinct from those of the facial skin?
### Response:
| It appears that the incomplete corneocyte formation of the lip surface is responsible for the poor barrier function and water-holding capacity. |
### Instruction:
Does high glucose-induced alterations in subendothelial matrix perlecan lead to increased monocyte binding?
### Response:
| These results illustrate that hyperglycemia-induced structural changes in perlecan may result in a SEM that is more favorable to retention of monocytes. |
### Instruction:
Is large artery stiffness related to plasma cholesterol in older subjects with hypertension?
### Response:
| In the largest cohort of elderly hypertensive subjects studied to date, plasma cholesterol per se was not associated with large artery stiffness. Such independence from cholesterol increases the potential for artery stiffness measurements to additionally contribute to cardiovascular risk assessment in this population. |
### Instruction:
Do synovial concentrations of the angiogenic peptides bFGF and VEGF discriminate rheumatoid arthritis from other forms of inflammatory arthritis?
### Response:
| Both serum bFGF and VEGF concentrations were increased in patients with rheumatoid arthritis. Patients treated with steroids had lower synovial fluid bFGF concentrations. Synovial fluid levels of bFGF and VEGF were elevated but could not be used to distinguish rheumatoid arthritis from other forms of inflammatory arthritis. |
### Instruction:
Does whole-body UVB ( TL-01 ) or UVA-1 irradiation alter the levels of immunomodulatory cytokines in the serum of human volunteers?
### Response:
| It seems unlikely that a modulation in these circulating cytokines assessed in this study accounts for systemic UV-induced immunosuppression in human subjects. |
### Instruction:
Do small early tubular adenomas and mixed colonic polyps found on screening flexible sigmoidoscopy predict proximal neoplasia in males?
### Response:
| Small ETAs, serrated, or mixed polyps found on flexible sigmoidoscopic examination do not increase the probability of synchronous proximal neoplasia. |
### Instruction:
Is controlled-release codeine equivalent to acetaminophen plus codeine for post-cholecystectomy analgesia?
### Response:
| Controlled-release codeine provides an equivalent onset of analgesia, reduction in postoperative pain, and level of patient satisfaction, to acetaminophen plus codeine, over 48 hr following cholecystectomy, with the advantage of less frequent dosing. |
### Instruction:
Do methylation patterns define two types of hyperplastic polyp associated with colorectal cancer?
### Response:
| The findings support the existence of morphological and molecular heterogeneity among HP and highlight a subset that is likely to have significant malignant potential. |
### Instruction:
Does intravenous administration of glutathione protect parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation?
### Response:
| Plasma GSH levels above a critical level may act as a "sink" for ROS produced in the hepatic vasculature during reperfusion of liver grafts. Therefore, GSH can be considered a candidate antioxidant for the prevention of reperfusion injury after liver transplantation, in particular since it has a low toxicity in humans. |
### Instruction:
Is the presence of non-organ-specific autoantibodies associated with a negative response to combination therapy with interferon and ribavirin for chronic hepatitis C?
### Response:
| The absence of non-organ-specific autoantibodies might indicate a significantly higher chance for viral clearance in response to combination therapy for chronic hepatitis C infection. Therefore, despite of an overall higher treatment response, the addition of the immunomodulatory drug ribavirin could accentuate immunological differences that affect treatment outcome and might have been less obvious in earlier studies analysing interferon monotherapy. |
### Instruction:
Do [ Study of sintering temperature of HN-97 porcelain stain ]?
### Response:
| The stain can be used once coloration and glaze for restoration of porcelain, autoglazing temperature of which is between 820-955 degrees centigrade and the operation is easy. |
### Instruction:
Is endotoxin-induced liver damage in rats minimized by beta 2-adrenoceptor stimulation?
### Response:
| The results indicate that a selective beta(2)-AR agonist might be used as an additional therapeutic agent in the clinic for the treatment of (acute) systemic inflammatory disorders in order to reduce or prevent subsequent liver failure. |
### Instruction:
Does sodium oxybate demonstrate long-term efficacy for the treatment of cataplexy in patients with narcolepsy?
### Response:
| This controlled trial provides evidence supporting the long-term efficacy of sodium oxybate for the treatment of cataplexy. In contrast with antidepressant drug therapy, there is no evidence of rebound cataplexy upon abrupt discontinuation of treatment. |
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