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### Instruction:
Is infection with herpes simplex virus type 1 associated with cognitive deficits in bipolar disorder?
### Response:
| Serologic evidence of herpes simplex virus type 1 infection is associated with cognitive impairment in individuals with bipolar disorder. |
### Instruction:
Are high nuclear grade and negative estrogen receptor significant risk factors for recurrence in DCIS?
### Response:
| Nuclear grade remains the most significant factor for breast recurrence after DCIS. Hormone receptor status identifies a subset of patients with more favourable prognosis. |
### Instruction:
Are self-reinforced bioresorbable poly-L/DL-lactide [ SR-P ( L/DL ) LA ] 70/30 miniplates and miniscrews reliable for fixation of anterior mandibular fractures : a pilot study?
### Response:
| SR-P(L/DL)LA 70/30 plates and screws are reliable for internal fixation of anterior mandibular fractures in adults. Proper soft tissue coverage should be ensured to avoid plate exposure. Should implant exposure occur, it might be necessary to excise the exposed part after fracture healing (6-8 weeks postoperatively). |
### Instruction:
Are retinal and choroidal biopsies helpful in unclear uveitis of suspected infectious or malignant origin?
### Response:
| Retinal or choroidal biopsy is a valuable investigation that often changes clinical management when carried out for specific indications in patients with uveitis of suspected malignant or infectious origin. Although it is likely to remain an investigation of last resort, it should be considered at an earlier stage when there is diagnostic uncertainty if severe visual loss is to be prevented. |
### Instruction:
Does human oocyte maturity in vivo determine the outcome of blastocyst development in vitro?
### Response:
| These phenomena suggest that oocyte maturity produced in vivo determine the fertilization potential and subsequent blastocyst quality in vitro. |
### Instruction:
Does administration of beta2-adrenergic agonists during the peri-implantation period improve implantation or pregnancy rates in intracytoplasmic sperm injection ( ICSI ) cycles?
### Response:
| The results of this study do not support the routine use of beta2-adrenergic agonists during the peri-implantation period in assisted reproductive technology cycles. |
### Instruction:
Do human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site?
### Response:
| We conclude that human pituitary glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site residues. In contrast to the aminopeptidase, however, QC does not appear to require zinc for enzymatic activity. |
### Instruction:
Does n-acetylcysteine attenuate lung injury in a rodent model of fracture?
### Response:
| N-acetyl cysteine, if given after skeletal trauma, is of potential therapeutic benefit, in preventing SIRS, ARDS and MOF. |
### Instruction:
Is longer breastfeeding an independent protective factor against development of type 1 diabetes mellitus in childhood?
### Response:
| Longer exclusive and total breastfeeding appears as an independent protective factor against type 1 diabetes. |
### Instruction:
Does clinical trial substantiate the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide?
### Response:
| This prospective clinical trial identifies MGMT-methylation status as an independent predictor for glioblastoma patients treated with a methylating agent. The association of the epigenetic inactivation of the DNA repair gene MGMT with better outcome in this homogenous cohort may have important implications for the design of future trials and supports efforts to deplete MGMT by O-6-benzylguanine, a noncytotoxic substrate of this enzyme. |
### Instruction:
Does reconstitution of caspase-3 confer low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage?
### Response:
| Our results suggest that caspase-3 is involved in the reduction of Akt level, and its involvement is mediated through caspase-9 activation. The reduction of Akt level is also due to cleavage of Akt rather than degradation of Akt. |
### Instruction:
Does insulin treatment improve the systemic inflammatory reaction to severe trauma?
### Response:
| Insulin attenuates the inflammatory response by decreasing the pro-inflammatory and increasing the anti-inflammatory cascade, thus restoring systemic homeostasis, which has been shown critical for organ function and survival in critically ill patients. |
### Instruction:
Is severe , but not mild , obstructive sleep apnea syndrome associated with erectile dysfunction?
### Response:
| Severe OSAS is clearly associated with ED. However, the relationship is very weak in patients with mild or moderate OSAS. The predictive factors for ED in patients with OSAS include age, morning tiredness, and RDI. |
### Instruction:
Does [ Studies on chemical constituents from the stem of Schisandra sphaerandra ]?
### Response:
| Three pentacyclic triterpene carboxylic acid (5-7) were isolated from Schisandreae for the first time. |
### Instruction:
Does perioperative intravenous lidocaine have preventive effects on postoperative pain and morphine consumption after major abdominal surgery?
### Response:
| The perioperative administration of systemic small-dose lidocaine reduces pain during surgery associated with the development of pronounced central hyperalgesia, presumably by affecting mechanoinsensitive nociceptors, because these have been linked to the induction of central sensitization and were shown to be particularly sensitive to small-dose lidocaine. |
### Instruction:
Does preoperative ketamine improve postoperative analgesia after gynecologic laparoscopic surgery?
### Response:
| In women undergoing laparoscopic gynecologic surgery, a small preoperative dose of ketamine (0.15 mg/kg) produced preemptive analgesia. There were no significant hemodynamic and psychological side effects with this dose. |
### Instruction:
Does preoperative oral rofecoxib reduce postoperative pain and tramadol consumption in patients after abdominal hysterectomy?
### Response:
| This study was designed to determine whether the administration of a preoperative dose of rofecoxib to patients undergoing abdominal hysterectomy would decrease patient-controlled analgesia tramadol use or enhance analgesia. We conclude that the preoperative administration of oral rofecoxib provided a significant analgesic benefit and decreased the opioid requirements in patients undergoing abdominal hysterectomy. |
### Instruction:
Do intrathecal clonidine and bupivacaine have synergistic analgesia for acute thermally or inflammatory-induced pain in rats?
### Response:
| The analgesic interaction between intrathecally administered bupivacaine and clonidine was examined during acute thermal and inflammatory-induced pain in rats. The analgesia produced by the combination of these two drugs was synergistic in both acute thermal and inflammatory induced pain, with a decrease in behavioral side effects. |
### Instruction:
Do osteoblast-derived factors induce androgen-independent proliferation and expression of prostate-specific antigen in human prostate cancer cells?
### Response:
| Osteoblasts secrete factors, such as IL-6, that cause androgen-independent induction of PSA gene expression and proliferation of prostate cancer cells by a mechanism that partially relies on the AR. Identifying such molecular mechanisms may lead to improved clinical management of metastatic prostate cancer. |
### Instruction:
Does interleukin 1beta enhance invasive ability of gastric carcinoma through nuclear factor-kappaB activation?
### Response:
| One of the molecules that may play a role in NF-kappaB activation in some gastric carcinomas is IL-1beta. The present results suggest that IL-1beta increases the invasive ability of carcinoma cells through activation of NF-kappaB and the resulting MMP-9 expression. |
### Instruction:
Is 0.03 % Tacrolimus ointment applied once or twice daily more efficacious than 1 % hydrocortisone acetate in children with moderate to severe atopic dermatitis : results of a randomized double-blind controlled trial?
### Response:
| 0.03% tacrolimus ointment applied once or twice daily is significantly more efficacious than 1% HA in treating moderate-severe AD in children. Twice daily application of 0.03% tacrolimus ointment results in the greatest improvement in mEASI, and is especially effective in patients with severe baseline disease. |
### Instruction:
Do a clinical study to assess the ability of a powered toothbrush to remove chlorhexidine/tea dental stain?
### Response:
| This study has suggested that the powered brush may become more effective at reducing dental stain, the longer the brush is used under normal home conditions. |
### Instruction:
Is donor history of asthma a contraindication to lung transplantation : 12-year single-center experience?
### Response:
| The use of lungs from carefully selected lung donors with a history of asthma may increase the donor pool with acceptable long-term outcomes. The use of fatal asthma donors remains problematic. |
### Instruction:
Does variation in breast cancer count using SEER and IARC multiple primary coding rules?
### Response:
| Breast cancer case counts are dependent on the multiple primary coding rules used. |
### Instruction:
Does sodium caseinate induce expression and secretion of murine multipotent myeloid cell line 32D macrophage colony-stimulating factor?
### Response:
| CasNa inhibits proliferation of 32D cells and induces expression of the gene for M-CSF and that of its receptor. It also induces secretion of the bioactive form of M-CSF. |
### Instruction:
Is target blood pressure for patients with type 2 diabetes difficult to achieve in the setting of a busy diabetes clinic?
### Response:
| Adequate blood pressure control was underachieved in this patient group underlying the difficulty in treating blood pressure to target values in patients with type 2 diabetes in the setting of outpatient diabetes clinics. A more aggressive strategy, in particular the use of multiple antihypertensive agents should be adopted. |
### Instruction:
Do adenovirus vectors targeting alphaV integrin or heparan sulfate receptors display different distribution of transgene activity after intramuscular injection?
### Response:
| The results of the present study demonstrate that altering Ad affinity for cellular receptors modulates the level and distribution of transgene activity, conferring characteristics that may allow for treatment customization. |
### Instruction:
Is hemoglobin content increased in the human erythroleukemia K562 cell line by a 56.2-kD peptide from uremic plasma?
### Response:
| This study shows that the addition of the 56.2-kD uremic factor to K562 cells was clearly implicated in heme disturbances existing in chronic renal failure but it did not play a negative role in the pathogenesis of the uremic anemia. |
### Instruction:
Does fimch antiserum inhibit the adherence of Escherichia coli to cells collected by voided urine specimens of diabetic women?
### Response:
| These findings suggest that a vaccine based on FimH adhesin of type 1 fimbriated E. coli is a potential method of preventing urinary tract infection in women with DM. |
### Instruction:
Does low oxygen tension stimulate the redifferentiation of dedifferentiated adult human nasal chondrocytes?
### Response:
| These observations demonstrate that using the present set-up, low oxygen tension stimulates the redifferentiation of dedifferentiated adult human nasal chondrocytes in pellet cultures. |
### Instruction:
Does a type XI collagen mutation lead to increased degradation of type II collagen in articular cartilage?
### Response:
| The results suggest a model in which cumulative biomechanical stresses trigger increased collagen synthesis and degradation in both +/+ and cho/+ mice at around 12 months of age. Cho/+ mice, however, are less able to synthesize and assemble normal replacement collagen fibrils because of the Col11a1 mutation. Degradation is further activated, resulting in the accumulation of degraded type II collagen in the articular cartilage extracellular matrix. Similar mutations that do not overtly affect skeletal development may likewise predispose humans to increased collagen degradation and resultant osteoarthritis. |
### Instruction:
Does prothrombin fragment 1+2 is associate with carotid intima-media thickness in subjects free of clinical cardiovascular disease?
### Response:
| In a population sample of adults without clinically overt atherosclerotic disease, the plasma levels of F1+2 were significantly associated with carotid IMT, suggesting a relationship between thrombin generation and the development atherosclerosis. |
### Instruction:
Does moderate physical exercise increase cardiac autonomic nervous system activity in children with low heart rate variability?
### Response:
| Our data suggest that the 12-month moderate exercise training has a positive effect on cardiac ANS activity in the children who initially had low HRV. |
### Instruction:
Is prognostic significance of p27 ( kip-1 ) expression in colorectal adenocarcinomas associated with tumor stage?
### Response:
| No prognostic significance was found for p27(kip-1) expression in stages I, II, or IV CRCs, and its prognostic value was not associated with either ethnicity or tumor location. These studies suggest that decreased expression of p27(kip-1) is an indicator of poor prognosis and aids in identifying a subset of patients with aggressive forms of stage III CRCs. |
### Instruction:
Is docetaxel combined with trastuzumab an active regimen in HER-2 3+ overexpressing and fluorescent in situ hybridization-positive metastatic breast cancer : a multi-institutional phase II trial?
### Response:
| Trastuzumab plus docetaxel is an active and well-tolerated regimen in women with HER-2 3+ overexpressing or FISH-positive metastatic breast cancer. |
### Instruction:
Are specific epileptic syndromes rare even in tertiary epilepsy centers : a patient-oriented approach to epilepsy classification?
### Response:
| Specific epilepsy syndromes included in the current ILAE classification are rare even in a tertiary epilepsy center. Most patients are included in unspecific categories that provide only incomplete information. In contrast, all of the patients could be classified by the five-dimensional patient-oriented classification, providing all essential information for the management of the patients with a high degree of interrater reliability. |
### Instruction:
Are areas of interictal spiking associated with metabolic dysfunction in MRI-negative temporal lobe epilepsy?
### Response:
| Metabolic dysfunction is present in focal areas of interictal spiking in nonlesional temporal lobe epilepsy. These findings confirm that functional abnormalities can be detected in vivo in radiographically normal-appearing cortex exhibiting abnormal excitability. |
### Instruction:
Do patients with temporoparietal ictal symptoms and inferomesial EEG benefit from anterior temporal resection?
### Response:
| We conclude that anterior and inferomesial interictal epileptiform temporal discharges and at times even intracranial EEG monitoring may be misleading. Anteromesial temporal resection is ineffective in patients with posterior temporoparietal clinical ictal features. |
### Instruction:
Is the histologic grade a main prognostic factor for patients with intracranial ependymomas treated in the microneurosurgical era : an analysis of 258 patients?
### Response:
| The application of a uniform diagnostic criteria for grading ependymomas highlighted the key role of tumor histology in clinical outcome in a cohort of patients who were treated in the microsurgical era. The recently proposed grading scheme is likely to be practically useful, reproducible, and clinically applicable. |
### Instruction:
Is bMD reduced in HIV-infected men irrespective of treatment?
### Response:
| Our cross-sectional study does not show any deleterious effect of the treatment but does indicate a decrease in bone density in HIV+ patients irrespective of the treatment. This low bone density is in part related to the low body weight and is associated with increased bone resorption. |
### Instruction:
Is platelet-derived endothelial cell growth factor expression an independent prognostic factor in colorectal cancer patients after curative surgery?
### Response:
| The PD-ECGF expression originated from stromal macrophages was a predictor for favorable outcome after curative resections for colorectal cancer. |
### Instruction:
Does a simple vascular calcification score predict cardiovascular risk in haemodialysis patients?
### Response:
| The present vascular calcification scoring represents a simple tool for the assessment of cardiovascular risk related with vascular calcifications in chronic HD patients. |
### Instruction:
Does denaturation of demineralized bone matrix significantly reduce bone formation by guided tissue regeneration?
### Response:
| Denaturation of DBM by heating significantly reduces bone formation by guided tissue regeneration. |
### Instruction:
Do regional body composition changes exhibit opposing effects on coronary heart disease risk factors?
### Response:
| Regional body composition information is important for evaluating improvement of CHD risk factors during weight-reduction treatment for obesity; differential FTs had opposing effects on CHD risk factors during weight reduction in obese women. |
### Instruction:
Do the efficacy of continuous fascia iliaca compartment block for pain management in burn patients undergoing skin grafting procedures?
### Response:
| Postoperative pain at the split skin donor sites is often more intense than the pain at the grafted site. This prospective, randomized, double-blind study assessed the efficacy of a continuous fascia iliaca compartment block in reducing the pain at the thigh donor site. |
### Instruction:
Does pulsed tissue Doppler imaging detect early myocardial dysfunction in asymptomatic patients with severe mitral regurgitation?
### Response:
| TDI systolic indices can predict postoperative left ventricular function in patients with asymptomatic MR undergoing surgical correction. |
### Instruction:
Is vascular endothelial growth factor increased in cerebrospinal fluid after traumatic brain injury in infants and children?
### Response:
| VEGF is increased in CSF after pediatric TBI, and this increase is associated with an increase in CSF adenosine. These results may imply that a component of the vascular regenerative response of the brain is initiated rapidly after TBI and continues for several days after injury. Further investigation is warranted to determine 1). whether this association is causative, 2). the role of adenosine in triggering the increase in CSF VEGF concentration, and 3). the exact role VEGF that plays after injury. |
### Instruction:
Is primary dystonia more responsive than secondary dystonia to pallidal interventions : outcome after pallidotomy or pallidal deep brain stimulation?
### Response:
| This study indicates that primary dystonia responds much better than secondary dystonia to pallidal procedures. We could not distinguish a difference in efficacy between pallidotomy and pallidal deep brain stimulation. The presence of basal ganglia abnormalities on the preoperative magnetic resonance imaging scan is an indicator of a lesser response to pallidal interventions for dystonia. |
### Instruction:
Is clinical course of atrial ectopic tachycardia age-dependent : results and treatment in children < 3 or > or =3 years of age?
### Response:
| Younger children respond to antiarrhythmic therapy and have a high incidence of AET resolution, thus warranting a trial of antiarrhythmic therapy. In children > or =3 years, AET is unlikely to resolve spontaneously, and antiarrhythmic medications are frequently ineffective. Thus, RFA should be considered early in the course of treatment for these children; however, surgical intervention may be necessary. |
### Instruction:
Do leukotrienes mediate 5-hydroxytryptamine-induced plasma extravasation in the rat knee joint via CysLT-type receptors?
### Response:
| These results demonstrate that leukotrienes, specifically cysteinyl-leukotrienes contribute to synovial plasma extravasation and suggest that leukotrienes act downstream of 5-HT in the inflammatory cascade. |
### Instruction:
Is contraction force rate of polymer composites linearly correlated with irradiance?
### Response:
| The pulse-delay method demonstrated contraction force rates lower than what would be expected using energy considerations and lower force rates at each of the two light exposures than their single exposure counterparts. Since the adhesive resin and dentin are viscoelastic and thus strain rate dependent, time dependent contraction force should be an important consideration. |
### Instruction:
Does warm steaming enhance the topical anesthetic effect of lidocaine?
### Response:
| We showed that the skin pretreatment with a steamed towel (at 45 degrees C) enhanced the anesthetic effect of a topical lidocaine tape in female volunteers. |
### Instruction:
Does gp91phox-containing NADPH oxidase mediate endothelial dysfunction in renovascular hypertension?
### Response:
| These data indicate that the formation of O2- by the endothelial gp91phox-containing NADPH oxidase accounts for the reduced NO bioavailability in the 2K1C model and contributes to the development of renovascular hypertension and endothelial dysfunction. |
### Instruction:
Do [ Comparative research on mixed and 488 nm argon laser PDT for port wine stain ]?
### Response:
| Argon laser PDT at 488 nm had the similar therapeutic result contrasted to mixed spectrum laser group, but it was safe. |
### Instruction:
Do [ Derma spectrometer measurement for port wine stain ]?
### Response:
| There is difference between normal and lesion M-Index. But none for lesion and lesion treated. Different E-Index were among normal skin, lesion and treated lesion. The E-Index was decreased at treated lesion. It suggested blanch of PWS after laser treatment. Derma spectrometer has the role of evaluation of PWS. |
### Instruction:
Do [ Specific psychopathologic reactions in refugee populations and victims of torture ]?
### Response:
| Based on the results torture is the most intense form of trauma leading to intensive psychopathological responses including chronic PTSD. Results show that the psychopathological response is most intense and most frequent in the population of torture survivors compared to the refugee population. |
### Instruction:
Are thymidylate synthetase mRNA levels increased in liver metastases of colorectal cancer patients resistant to fluoropyrimidine-based chemotherapy?
### Response:
| This is the first report to demonstrate increased TS expression in liver metastases from CRC patients resistant to fluoropyrimidine based chemotherapy. These findings are consistent with previous studies indicating that increased TS expression is associated with resistance to fluoropyrimidine-based chemotherapy. |
### Instruction:
Does glutathione S-Transferase Omega 1 variation influence age at onset of Huntington 's disease?
### Response:
| The GSTO1 and GSTO2 genes flanked by the investigated polymorphisms are not comprised in a primary candidate region influencing AO in HD. |
### Instruction:
Does postnatal repeated maternal deprivation produce age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions?
### Response:
| Our data suggest that MD produces a significant reduction of BDNF expression within prefrontal cortex and striatum, which may render these structures less plastic and more vulnerable under challenging conditions. |
### Instruction:
Is mitochondrial complex I subunits expression altered in schizophrenia : a postmortem study?
### Response:
| The schizophrenia-specific reduction in complex I subunits in the prefrontal cortex is consistent with one of schizophrenia's most prominent deficits, namely, hypofrontality, thus further supporting the hypothesis of mitochondrial dysfunction in this disorder. The abnormal, bidirectional expression of complex I in various brain regions, rather than in a circumscribed area, supports the idea of impaired cerebral circuitry in schizophrenia. |
### Instruction:
Is age at natural menopause linked with the follicle-stimulating hormone receptor region : a sib-pair study?
### Response:
| Possibly, age at natural menopause in the more or less normal range is not part of the spectrum of phenotypes determined by mutations in the FSH-receptor gene. Alternatively, our results might be explained by genetic heterogeneity in the left tail of the distribution of menopausal age. This can limit the chance of finding a genetic locus, especially if this factor has a modest contribution to the phenotype. |
### Instruction:
Does preservation of the anterior fat pad paradoxically decrease the incidence of postoperative atrial fibrillation in humans?
### Response:
| This is the first study demonstrating that direct stimulation of the human anterior epicardial FP slows sinus CL. This parasympathetic effect is eliminated with FP dissection. Preservation of the human anterior epicardial FP during CABG decreases incidence of postoperative AF. |
### Instruction:
Does isoflurane pretreatment support hemodynamics and leukocyte rolling velocities in rat mesentery during lipopolysaccharide-induced inflammation?
### Response:
| Isoflurane pretreatment supported hemodynamics and increased leukocyte rolling velocities in the mesenteric microcirculation during lipopolysaccharide-induced inflammation. Faster rolling velocities may reduce the incidence of inflammation by decreasing leukocyte-endothelial interactions and cellular injury. |
### Instruction:
Does loss of BRCA2 correlate with reduced long-term survival of sporadic breast cancer patients?
### Response:
| Allelic loss at the BRCA2 locus may be of use as a negative predictor for metastases-free and overall survival. |
### Instruction:
Is polo-like kinase 1 ( PLK1 ) expression associated with cell proliferative activity and cdc2 expression in malignant lymphoma of the thyroid?
### Response:
| These results suggest that PLK1 regulates the cell cycle progression of thyroid lymphoma cells in the G2-M-phase. |
### Instruction:
Does hydroxy-methylglutaryl-coenzyme A reductase inhibition improve endothelial dysfunction in type-1 diabetes?
### Response:
| These data confirm the presence of endothelial dysfunction in young patients with type-1 diabetes. We have shown that 1-month of Pravastatin treatment normalizes FMD. This suggests that HMG CoA reductase inhibitors may have a role in the management of diabetes mellitus, even in the presence of normal serum cholesterol levels. |
### Instruction:
Is elevation in plasma MMP-9 following carotid endarterectomy associated with particulate cerebral embolisation?
### Response:
| Plasma MMP-9 only rises after CEA in patients with evidence of embolisation. This increase is more pronounced in those with high numbers of emboli. These data suggest that the increase in MMP-9 is due to cerebral damage caused by embolisation. |
### Instruction:
Does mental stress inhibit pain perception and heart rate variability but not a nociceptive withdrawal reflex?
### Response:
| Distraction by PASAT altered autonomic activity and inhibited pain but failed to affect withdrawal reflex responses, while attention had no effect on either parameter. Psychological distraction and attention may have different effects on noxious evoked pain perception and autonomic activity. Pain relief during PASAT probably involves supraspinal mechanisms. |
### Instruction:
Is laparoscopy-assisted surgery for colorectal neoplasm justifiable regardless of advanced age?
### Response:
| Laparoscopy-assisted surgery is a satisfactory treatment for colorectal neoplasm, even in geriatric patients. |
### Instruction:
Do distributions in CEA doubling time differ in patients with recurrent colorectal carcinomas?
### Response:
| CEA DT serves to predict life expectancy for patients with recurrent colorectal cancers with different tumor distributions. We propose that precise measurements of serum CEA are needed so as not to overlook recurrent tumors. Detailed follow-up after operations is necessary for such patients, that CEA DT was noted in case of distal colon cancers. |
### Instruction:
Does intestinal ischemia-reperfusion injury augment intestinal mucosal injury and bacterial translocation in jaundiced rats?
### Response:
| Intestinal mucosa is disturbed more severely in obstructive jaundice with the development of ischemia and reperfusion. Development of intestinal ischemia-reperfusion in obstructive jaundice increases bacterial translocation. |
### Instruction:
Are p16INK4A gene alterations a prognostic indicator for survival in patients with hepatocellular carcinoma undergoing curative hepatectomy?
### Response:
| p16INK4A is altered frequently and early in HCC, being the predominant mechanism of inactivation promoter hypermethylation. The present results suggest that the p16INK4A gene plays an important role in the pathogenesis of HCC. |
### Instruction:
Does alexithymia predict the persistence of medically unexplained physical symptoms?
### Response:
| Outcome of the UPS and general health perception at follow-up are not strongly associated and are predicted by different variables. Alexithymia, however, is not an important predictor for the outcome in the majority of UPS patients. |
### Instruction:
Does treatment with hypnotherapy reduce the sensory and motor component of the gastrocolonic response in irritable bowel syndrome?
### Response:
| Hypnotherapy reduces the sensory and motor component of the gastrocolonic response in patients with irritable bowel syndrome. These effects may be involved in the clinical efficacy of hypnotherapy in IBS. |
### Instruction:
Is normal tension glaucoma associated with the common apolipoprotein E gene polymorphisms?
### Response:
| ApoE gene polymorphisms are not linked to normal tension glaucoma, suggesting that this gene does not have a role in the pathogenesis of optic neuropathy in this disease. |
### Instruction:
Does thymosin-beta4 inhibit corneal epithelial cell apoptosis after ethanol exposure in vitro?
### Response:
| Tbeta(4) plays an antiapoptotic role under conditions of epithelial cell challenge with an external stress such as exposure to ethanol. Tbeta(4) may function as an antiapoptotic agent by inhibiting the release of cytochrome c from mitochondria and by suppressing the activation of caspases. |
### Instruction:
Does subcutaneous and continuous administration of lipopolysaccharide increase serum levels of triglyceride and monocyte chemoattractant protein-1 in rats?
### Response:
| These findings suggest that chronic infection such as periodontal disease induces hypertriglyceridemia and increases serum MCP-1 levels in a manner that increases the risk of atherosclerotic cardiovascular disease. |
### Instruction:
Does removal of peri-gastric fat prevent acute obstruction after Lap-Band surgery?
### Response:
| Routine removal of peri-gastric fat pads when using the pars flaccida technique for Lap Band surgery appears to prevent postoperative esophageal obstruction. |
### Instruction:
Does short-term ex vivo expansion sustain the homing-related properties of umbilical cord blood hematopoietic stem and progenitor cells?
### Response:
| These data demonstrate that, although ex vivo expansion may alter cell properties, our one-week expansion protocol can preserve most of the homing-related characteristics and activities of UCB HSPC. |
### Instruction:
Is darifenacin , an M3 selective receptor antagonist , an effective and well-tolerated once-daily treatment for overactive bladder?
### Response:
| Darifenacin significantly improves the major symptoms of OAB. No significant CNS (primarily M1-receptor mediated) adverse events or cardiac (primarily M2-receptor mediated) adverse events were identified in this study, as may be predicted from the M3 selective receptor profile of darifenacin. |
### Instruction:
Does an extended 10-core transrectal ultrasonography guided prostate biopsy protocol improve the detection of prostate cancer?
### Response:
| Adding 4 lateral peripheral biopsies to the conventional sextant biopsy (10-core biopsy strategy) technique has increased the cancer detection rate by 25.5% without significant morbidity and without increasing the number of insignificant cancers. 10-core biopsy protocol was superior to all probable 8-core biopsy protocols in our study group. Additional biopsies from suspicious areas detected by transrectal ultrasonography revealed no further benefit if 10-core technique was used. We therefore suggest that 10-core biopsy protocol should be the preferred strategy in early detection of prostate cancer. |
### Instruction:
Does venous blood redistribution alter the accuracy of Omron HEM-705CP?
### Response:
| Even if an oscillometric device passes various validation tests, they do not give sufficient information about its accuracy during venous blood redistribution. This knowledge is of particular importance when BP regulation abnormalities occurring during changes in body position are diagnosed with the oscillometric method. |
### Instruction:
Are kinetics of rotavirus infection in mice altered in a ground-based model of spaceflight?
### Response:
| These data are the first examination of the mucosal immune response to an enteric viral pathogen under simulated spaceflight conditions and indicate that rotavirus immunity was not impacted in this model. |
### Instruction:
Are gastric mucosal mast cells increased in Helicobacter pylori-negative functional dyspepsia?
### Response:
| Mast cells are increased in functional dyspepsia, independently of inflammation. This might contribute to the pathogenesis of functional dyspepsia by altering signaling in the brain-gut axis. |
### Instruction:
Are fluctuating transglutaminase autoantibodies related to histologic features of celiac disease?
### Response:
| In children with TGAA seropositivity, the TGAA level varied over time and a higher titer predicted an abnormal biopsy characteristic of CD. A threshold for biopsy for diagnosis of CD could be set higher for screening-identified cases than for clinically identified cases to decrease the frequency of performing "normal" biopsies. |
### Instruction:
Is glucose intolerance , as reflected by hemoglobin A1c level , associated with the incidence and severity of transplant coronary artery disease?
### Response:
| Persistent glucose intolerance, as reflected by plasma HbA(1c), is associated with the occurrence of TxCAD and may play an important role in its pathogenesis. |
### Instruction:
Does the CYP2C8 inhibitor trimethoprim increase the plasma concentrations of repaglinide in healthy subjects?
### Response:
| Trimethoprim raised the plasma concentrations of repaglinide probably by inhibiting its CYP2C8-mediated biotransformation. Although the interaction did not significantly enhance the effect of repaglinide on blood glucose concentration at the drug doses used, the possibility of an increased risk of hypoglycaemia should be considered during concomitant use of trimethoprim and repaglinide in patients with diabetes. |
### Instruction:
Does expression of HIV-1 integrase in CEM cells inhibit HIV-1 replication?
### Response:
| Expression of IN in CEM cells inhibits HIV-1 replication by a cumulative inhibitory effect on integration and particle production, in accord with the known pleiotropic interactions of IN. The inhibition of HIV-1 replication in CEM cells expressing the N-terminal domain of IN may lead to a novel approach for the gene therapy of AIDS. |
### Instruction:
Do children show decreased dynamic balance after mild traumatic brain injury?
### Response:
| Children with a mild TBI still showed balance deficits at 12 weeks postinjury. These deficits should be taken into consideration when planning a return to physical activities, particularly to those that require subtle balance skills. |
### Instruction:
Do [ Interleukin-5 regulate the bone marrow response in the model of allergic rhinitis ]?
### Response:
| IL-5 regulates the proliferation and differentiation of eosinophils in bone marrow. |
### Instruction:
Does lipopolysaccharide administration enhance hypoxic-ischemic brain damage in newborn rats?
### Response:
| LPS potentiates hypoxic-ischemic insult in a dose-dependent fashion to cause brain damage in neonatal rats. |
### Instruction:
Is glutathione S-transferase M1 gene polymorphism related to COPD in patients with non-small-cell lung cancer?
### Response:
| The present study suggests that in patients with non-small-cell lung cancer the presence of at least one active allele in GSTM1 has a protective effect against the development of COPD. |
### Instruction:
Do first-degree relatives of patients with advanced colorectal adenomas have an increased prevalence of colorectal cancer?
### Response:
| Relatives patients with advanced colorectal adenomas have an increased risk of colorectal cancer. Individuals with advanced colorectal adenomas should be counseled about the increased risk of colorectal cancer among their relatives. |
### Instruction:
Do patients with extratemporal lobe epilepsy differ from healthy subjects with respect to subcortical volumes?
### Response:
| We concluded that extratemporal lobe epilepsy in general is not associated with diminished volumes in the studied subcortical structures, which contrasts with findings in temporal lobe epilepsy patients. Thus, both entities differ both cortically and subcortically. However, we found that small putamen volume was bilaterally associated with absent or rare generalised tonic-clonic seizures, implicating the putamen in the control of the most disabling seizure type, independent of the site of neocortical focus. |
### Instruction:
Does salivary calcium reflect skeletal bone density of heavy smokers?
### Response:
| Heavy smokers seem to have lower bone mineral density and higher salivary calcium than their non-smoking counterparts. We suggest that the high salivary calcium concentration of smokers is in connection with skeletal calcium disturbances. |
### Instruction:
Does incisor disocclusion in rats affect mandibular condylar cartilage at the cellular level?
### Response:
| It is demonstrated that after 7 days, unilateral incisor disocclusion affects the mandibular condylar cartilage at the cellular level by increasing the mitotic activity and by accelerating chondrocytes maturation. Chondrocytes maturation appears more accelerated on the side opposite to incisor disocclusion. |
### Instruction:
Does clopidogrel increase bleeding and allogenic blood transfusion in coronary artery surgery?
### Response:
| The results of this study suggest that preoperative use of clopidogrel is not associated with increased bleeding and need for surgical exploration as well as risk of blood and blood product transfusion after CABG. |
### Instruction:
Does cardioplegic arrest increase the risk of atrial fibrillation after coronary artery bypass surgery?
### Response:
| Neither cardiopulmonary bypass nor cardioplegic arrest increases the risk of postoperative AF after CABG. |
### Instruction:
Is morphine the only analgesic in palliative care : literature review?
### Response:
| Nurses need to be aware of treatment options that may benefit patients with difficult pain problems. Although positive experiences have been documented when using alternatives to morphine, more research must be conducted to allow practitioners to add more pharmaceutical alternatives to their pain management armouries. |
### Instruction:
Does neutralizing antibody against interleukin-6 attenuate posthemorrhagic vasospasm in the rat femoral artery model?
### Response:
| These results indicate that cytokine-mediated inflammation is active in the setting of posthemorrhagic vasospasm produced by the rat femoral artery model. In particular, the profound increase in IL-6 levels after exposure to hemorrhage and the ability of a polyclonal antibody against IL-6 to reduce vasospasm suggest that IL-6 may play a prominent role in the development of vasospasm in this model. |
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