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### Instruction:
Is asymmetric dimethyl L-arginine ( ADMA ) a critical regulator of myocardial reperfusion injury?
### Response:
| Accumulation of tissue ADMA by impairment of DDAH was found to be a significant determinant of reperfusion injury. Our results indicate that ADMA could be a potential new target for the treatment of myocardial ischemia/reperfusion injury. |
### Instruction:
Does rhoA activation contribute to sex differences in vascular contractions?
### Response:
| We conclude that increased contractions to serotonin in aorta from male mice are attributable to differences in RhoA/Rho-kinase activation in smooth muscle independent of differences in the expression of RhoA or Rho-kinase. |
### Instruction:
Are high C-reactive protein and low cholesterol levels prognostic markers of survival in severe sepsis?
### Response:
| Serum C-reactive protein and cholesterol are a predictor of survival in patients with severe sepsis. Low cholesterol and high C-reactive protein levels appear as a valuable tool for individual risk assessment in severe sepsis patients and for stratification of high-risk patients in future intervention trials. |
### Instruction:
Are functional cortical changes of the sensorimotor network associated with clinical recovery in multiple sclerosis?
### Response:
| Pseudotumoral MS lesions affecting the motor system can determine short-term cortical changes characterized by the recruitment of pathways in the unaffected hemisphere. The regain of function of motor areas of the affected hemisphere seems to be a critical factor for a favorable recovery. |
### Instruction:
Does genetic polymorphism of CYP2D6 influence susceptibility to papillary thyroid cancer?
### Response:
| The results suggest that the poor metaboliser genotype is associated with a protective effect against PTC. This could be explained by a possible role of CYP2D6 on the metabolic activation of putative environmental chemical thyroid carcinogens or by linkage to another cancer-causing gene. Further research may allow the identification of metabolic risk factors and contribute towards understanding the molecular mechanisms involved in thyroid carcinogenesis. |
### Instruction:
Do norfloxacin and trimethoprim-sulfamethoxazole therapy have similar efficacy in prevention of spontaneous bacterial peritonitis?
### Response:
| Our findings suggest N and TS have similar efficacy in preventing SBP. This has significant implications for both the cost of SBP prophylaxis and the prevalence of fluoroquinolone resistance in patients with cirrhosis. |
### Instruction:
Does exercise training normalize sympathetic outflow by central antioxidant mechanisms in rabbits with pacing-induced chronic heart failure?
### Response:
| These results suggest that an upregulation in central antioxidative mechanisms and suppressed central prooxidant mechanisms may contribute to the exercise training-induced beneficial effects on autonomic activity in CHF. |
### Instruction:
Are aHSG gene polymorphisms associated with bone mineral density in Caucasian nuclear families?
### Response:
| These data suggest the polymorphisms in the AHSG gene may have effects on BMD variation in Caucasian population. |
### Instruction:
Are m cells involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis?
### Response:
| Membranous epithelial cells (M cells) play a key role in the pathogenesis of CL-GPC for the binding and translocation of antigen and pathogen. |
### Instruction:
Is phosphorylation of eIF2alpha required for mRNA translation inhibition and survival during moderate hypoxia?
### Response:
| Disruption of eIF2alpha phosphorylation is a potential target for hypoxia-directed molecular cancer therapy. |
### Instruction:
Is resveratrol-induced apoptosis associated with activation of p53 and inhibition of protein translation in T47D human breast cancer cells?
### Response:
| These findings demonstrate that RSVL affects multiple intracellular signaling transduction pathways such as p53 activation/protein translation inhibition/apoptosis, and strongly support a contemplated use of this natural compound as a preventive and/or an adjuvant therapeutic drug for breast cancer. The data indicate that these proteins may be used as predictive biomarkers to evaluate the treatment efficacy of RSVL in clinical trials. |
### Instruction:
Do supplemental feedings increase self-selected work output during wildfire suppression?
### Response:
| Liquid and/or solid supplemental CHO and regular feedings increased self-selected work rates during wildland fire suppression, particularly during the latter hours of the workday. |
### Instruction:
Do racial/ethnic differences in physician distrust in the United States?
### Response:
| Racial/ethnic differences in physician distrust are less uniform than previously hypothesized, with substantial geographic and individual variation present. |
### Instruction:
Is gH responsiveness in a large multinational cohort of SGA children with short stature ( NESTEGG ) related to the exon 3 GHR polymorphism?
### Response:
| Our data, based on a large cohort, showed that the exon 3 GHR polymorphism is associated with responsiveness to rhGH treatment in SGA children with short stature. |
### Instruction:
Does no association exist between E-cadherin gene polymorphism and tumor recurrence in patients with hepatocellular carcinoma after transplantation?
### Response:
| The results of this study show no association exists between the E-cadherin genotype and the risk of tumor recurrence in Chinese patients with HCC. |
### Instruction:
Does metabolic stress with a high carbohydrate diet increase adiponectin levels?
### Response:
| Metabolic stress with a high-carbohydrate diet increases plasma levels of adiponectin. Further studies will elucidate whether this is a transitory compensatory mechanism or a sign of target organ resistance to adiponectin. |
### Instruction:
Is periodontitis characterized by elevated PAI-1 activity?
### Response:
| In periodontitis, elevated levels of PAI-1 activity are observed compared with healthy controls. This may increase the potential for impaired fibrinolysis, a condition that results in a prothrombotic state. We suggest that this state, if left untreated, may contribute to an increased risk for CVD. |
### Instruction:
Does activation of invariant natural killer T cells by synthetic glycolipid ligands suppress autoantibody-induced arthritis?
### Response:
| These findings suggest that activation of iNKT cells with glycolipid ligands holds promise with regard to the treatment of autoimmune diseases such as rheumatoid arthritis. SGL-S23 has clinical benefit over alpha-galactosylceramide since it induces a weaker cytokine production response in iNKT cells, therefore reducing potential side effects caused by excessive cytokine release. |
### Instruction:
Is serum matrix metalloproteinase 3 an independent predictor of structural damage progression in patients with ankylosing spondylitis?
### Response:
| These results indicate that MMP-3 is a significant independent predictor of radiographic progression in patients with AS, particularly in those with preexisting radiographic damage. |
### Instruction:
Are severe coronary artery calcifications associated with ischemia in patients undergoing medical therapy?
### Response:
| The presence of a CAC score greater than 400 is associated with ischemia in a population receiving good medical therapy. The detection of significant CAC in these individuals warrants additional evaluation for ischemia. |
### Instruction:
Are age-related cataracts in alpha3Cx46-knockout mice dependent on a calpain 3 isoform?
### Response:
| The present study shows for the first time that calpain 3 is necessary for the formation of age-dependent nuclear cataracts in alpha3Cx46-/- mice. Evidence that the calpain 3 gene is directly involved in, or part of the pathway that leads to, gamma-crystallin cleavage is presented. These results are consistent with the hypothesis that the loss of alpha3Cx46 leads to increased levels of Ca2+ ions, and this increase activates the CAPN3 isoform, Lp82/85, which results in the formation of a nuclear cataract. |
### Instruction:
Do presence of hepatitis B virus core promoter mutations pre-seroconversion predict persistent viral replication after HBeAg loss?
### Response:
| The presence of core promoter mutations prior to HBeAg loss identified those patients in whom HBV DNA persisted at high levels and was associated with temporary re-emergence of serum HBeAg. These patients may benefit from early anti-viral treatment. |
### Instruction:
Do caveolin-1 knockout mice have increased bone size and stiffness?
### Response:
| These data suggest that cav-1 helps to maintain a less differentiated state of osteoblast progenitor cells, and the absence of cav-1 causes bone to mature more rapidly. Caveolin-1 may thus be a target for altering skeletal homeostasis. |
### Instruction:
Are low E2F1 transcript levels a strong determinant of favorable breast cancer outcome?
### Response:
| Assessment of E2F1 at the mRNA level in primary breast cancer is a strong determinant of breast cancer patient outcome. E2F1 expression identified patients at low risk of metastasis irrespective of the estrogen receptor and ERBB2 status, and demonstrated similar prognostic performance to different gene expression-based predictors. |
### Instruction:
Do effect of 9 mm tibial tuberosity advancement on cranial tibial translation in the canine cranial cruciate ligament-deficient stifle?
### Response:
| These data confirm that TTA does reduce CTT in tCCL stifles in this model. The CTT noted was less than that noted clinically. The addition of a simulated quadriceps force to a CCL-deficient stifle before a TTA, by itself, may not significantly lessen CTT. |
### Instruction:
Does inhibition of telomerase with human telomerase reverse transcriptase antisense enhance tumor necrosis factor-alpha-induced apoptosis in bladder cancer cells?
### Response:
| AS PS-ODN can significantly inhibit telomerase activity by downregulating the hTERT mRNA and protein expression. Treatment with AS PS-ODN may be a potential and most promising strategy for bladder cancer with telomerase activity. |
### Instruction:
Does acid reflux into the oesophagus influence exercise-induced airway narrowing in bronchial asthma?
### Response:
| The results indicate that acid in the oesophagus, or its short-term inhibition by proton pump inhibitors, has no influence on exercise-induced bronchoconstriction. |
### Instruction:
Does cross-study analysis of gene expression data for intermediate neuroblastoma identify two biological subtypes?
### Response:
| Our findings support the hypothesis that neuroblastoma consists of two biologically distinct subgroups that differ by characteristic gene expression patterns, which are associated with divergent clinical outcome. |
### Instruction:
Does mammographic density correlate with Ki-67 expression or cytomorphology in benign breast cells obtained by random periareolar fine needle aspiration from women at high risk for breast cancer?
### Response:
| Given the lack of correlation of mammographic breast density with either cytomorphology or Ki-67 expression in RPFNA specimens, mammographic density and Ki-67 expression should be considered as potentially complementary response biomarkers in breast cancer chemoprevention trials. |
### Instruction:
Does human Polycomb group EED protein negatively affect HIV-1 assembly and release?
### Response:
| Our data suggested that EED exerted an antiviral activity at the late stage of HIV-1 replication, which included genomic RNA packaging and virus assembly, resulting possibly from a mistrafficking of viral genomic RNA (gRNA) or gRNA/Gag complex. Nef reversed the EED negative effect on virus production, a function which required the integrity of the Nef N-terminal domain, but not its N-myristoyl group. The antagonistic effect of Nef correlated with a cellular redistribution of both EED and Nef. |
### Instruction:
Is renal pathological change in patients with type 2 diabetes always diabetic nephropathy : a report of 52 cases?
### Response:
| NDRD was a common feature in Type 2-diabetic patients with renal involvement. The absence of retinopathy and short periods of diabetic history may be useful indicators for diagnosis of NDRD clinically. |
### Instruction:
Is iGF-I receptor required for the anabolic actions of parathyroid hormone on bone?
### Response:
| Our results indicate that the IGF-IR null mutation in mature osteoblasts leads to less bone and decreased bone formation, in part because of the requirement for the IGF-IR in mature osteoblasts to enable PTH to stimulate osteoprogenitor cell proliferation and differentiation. |
### Instruction:
Does urokinase plasminogen activator receptor affect bone homeostasis by regulating osteoblast and osteoclast function?
### Response:
| The defective proliferation and differentiation of bone cells, coincident with both aberrant expression of transcription factors and cytoskeletal organization, are typical uPAR-dependent molecular phenotypes, and we have now shown their function in osteoblasts and osteoclasts function in vivo. |
### Instruction:
Does acute or subchronic clozapine treatment ameliorate prepulse inhibition ( PPI ) deficits in CPB-K mice with low levels of hippocampal NMDA receptor density?
### Response:
| In summary, (1) this study confirmed our working hypothesis: Lower levels of hippocampal glutamatergic receptor densities correspond to lower sensorimotor gating in CPB-K mice, and (2) acute or subchronic treatment with CLZ did not elevate low PPI levels in CPB-K mice. Thus, further experiments will concentrate on other antipsychotic drugs to prove the predictive validity of this animal model. |
### Instruction:
Do cCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5 HIV-1?
### Response:
| These results suggest that CCR5 density levels in HIV-1 patients may impact the activity of T-20 against R5 strains and that therapeutic approaches to alter CCR5 density may potentiate T-20. |
### Instruction:
Is type IV collagen 7s domain an independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stage?
### Response:
| This is the first report to demonstrate a consistent and profound elevation of the type IV collagen 7s domain in NASH patients with advanced fibrosis (before progression to the stage of cirrhosis) compared with those with mild fibrosis. |
### Instruction:
Is expression of LIM kinase 1 associated with reversible G1/S phase arrest , chromosomal instability and prostate cancer?
### Response:
| Our results show that increased expression of LIMK1 results in chromosomal abnormalities, aberrant cell cycle progression and alteration of normal cellular response to microtubule stabilizing agent Taxol; and that LIMK1 expression may be associated with cancerous phenotype of the prostate. |
### Instruction:
Is thrombotic thrombocytopenic purpura in a patient with Brucella infection highly responsive to combined plasma infusion and antimicrobial therapy?
### Response:
| This report shows that therapy of underlying infection together with plasma infusion may be a successful treatment option for brucellosis-induced TTP. |
### Instruction:
Does stimulation of rat erythrocyte P2X7 receptor induce the release of epoxyeicosatrienoic acids?
### Response:
| EETs are produced and released from RBCs via a mechanism that is mediated by ATP stimulation of P2X(7) receptors coupled to ATP transporters, pannexin-1 and CFTR. |
### Instruction:
Does hepatitis B viral load predict survival of HCC patients undergoing systemic chemotherapy?
### Response:
| For HCC patients with HBV chronic infection/exposure, a high viral load prior to treatment is an adverse factor for survival and may be associated with a higher incidence of severe hepatitis during chemotherapy. Future strategies to improve the prognosis of HCC patients undergoing chemotherapy should consider supportive therapy that incorporates antiviral therapies to reduce HBV viral load. |
### Instruction:
Is elevated plasma osteopontin level predictive of cirrhosis in patients with hepatitis B infection?
### Response:
| These data suggest that OPN could be used to evaluate the existence of LC, as OPN has previously been reported to be increased in the HCC; this unique feature makes OPN a promising candidate for prediction biomarker in the long-time surveillance of patients with HBV infection to evaluate the risk of cirrhosis and cancer. |
### Instruction:
Is expression pattern analysis of transcribed HERV sequences complicated by ex vivo recombination?
### Response:
| As RT-PCR probably will be instrumental for isolating an infectious HERV-K(HML-2) variant, generation of "new" HERV-K(HML-2) sequences by ex vivo recombination seems inevitable. Further complicated by an unknown amount of allelic sequence variation in HERV-K(HML-2) proviruses, newly identified HERV-K(HML-2) variants should be interpreted very cautiously. |
### Instruction:
Are c-reactive protein levels unaffected by metformin during pretreatment and an IVF cycle in women with polycystic ovary syndrome?
### Response:
| In infertile PCOS women, CRP levels are unaffected by metformin treatment. The CRP level increases during IVF treatment, and this increase is unaffected by concomitant metformin. We observed an association between CRP levels and body mass index. |
### Instruction:
Is sarcoglycan immunoreactivity lacking in infantile hypertrophic pyloric stenosis . A confocal laser scanning microscopic study?
### Response:
| The absence of sarcoglycans within the hypertrophied pyloric muscle may be a predisposing factor in the pathogenesis of IHPS since it could alter the normal physiology of SMCs through the modifications of structural integrity of sarcolemma and signaling between the extracellular and intracellular compartment. |
### Instruction:
Do malarial pigment haemozoin , IFN-gamma , TNF-alpha , IL-1beta and LPS stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes?
### Response:
| Results indicate that human monocytes fed or not with HZ/sHZ were constantly unable to express iNOS and generate NOS metabolites even after stimulation with IFN-gamma or a cytokine-LSP mix that were very active on HZ-fed murine phagocytic lines. Present data do not support the hypothesis that monocytes are mediators of anti-parasitic defence in clinical malaria via activation of iNOS and production of NO, and suggest caution in extrapolating data obtained with murine or hybrid systems to human malaria. |
### Instruction:
Does bone mineral density remain stable in HAART-treated HIV-infected men over 2 years?
### Response:
| Accelerated bone loss does not occur in HIV-infected men treated with HAART. Monitoring of BMD in HIV-infected men may not be necessary. |
### Instruction:
Are free triiodothyronine and thyroid stimulating hormone directly associated with waist circumference , independently of insulin resistance , metabolic parameters and blood pressure in overweight and obese women?
### Response:
| Progressive central fat accumulation is associated with an increase in both FT3 and TSH serum levels, independently of insulin sensitivity, metabolic parameters and blood pressure. These results suggest that (1) progressive central fat accumulation is associated with a parallel increase in FT3 levels, possibly as an adaptive thermogenic phenomenon, and (2) the control of TSH secretion by free thyroid hormones is possibly impaired in obesity. |
### Instruction:
Does acute EGCG supplementation reverse endothelial dysfunction in patients with coronary artery disease?
### Response:
| EGCG acutely improves endothelial function in humans with coronary artery disease, and may account for a portion of the beneficial effects of flavonoid-rich food on endothelial function. |
### Instruction:
Is dietary linolenic acid intake positively associated with five-year change in eye lens nuclear density?
### Response:
| Higher ALA intake was associated with a greater age-related change in lens nuclear density. |
### Instruction:
Are lactating women restricting milk low on select nutrients?
### Response:
| Milk restriction compromised protein and nutrient intakes in lactating women who restricted milk to <250 mL. Vitamin/mineral supplements helped exclusively breastfeeding milk restrictors improve their vitamin D and calcium intakes. Milk restriction is not recommended during lactation and where unavoidable, nutrients provided by milk should be compensated for by other foods or supplements. |
### Instruction:
Is loss of control of asthma following inhaled corticosteroid withdrawal associated with increased sputum interleukin-8 and neutrophils?
### Response:
| Rapid withdrawal of inhaled corticosteroids results in an exacerbation of asthma that is preceded by an increase in sputum neutrophils and IL-8 concentrations, in contrast to an increase in eosinophils reported in previous studies in which inhaled steroids are slowly tapered. |
### Instruction:
Does the quality of chest compressions during cardiopulmonary resuscitation override importance of timing of defibrillation?
### Response:
| In this animal model of cardiac arrest, it was the quality of the chest compressions, rather then the priority of either initial defibrillation or initial chest compressions, that was the predominant determinant of successful resuscitation. |
### Instruction:
Does aDMA correlate with portal pressure in patients with compensated cirrhosis?
### Response:
| These results suggest that ADMA may play a pathophysiological role in portal hypertension by contributing to the relative intrahepatic NO deficiency typical of endothelial dysfunction. |
### Instruction:
Does atorvastatin therapy improve exercise oxygen uptake kinetics in post-myocardial infarction patients?
### Response:
| In post-MI patients exercise performance is a potential additional target of benefits related to statin therapy. Endothelial function improvement is very likely implicated in this newly described therapeutic property. |
### Instruction:
Is the IS6110 repetitive DNA element of Mycobacterium tuberculosis detected in exhaled breath condensate of patients with active pulmonary tuberculosis?
### Response:
| The IS6110 repetitive DNA element of M. tuberculosis is not detected in exhaled breath condensate of patients with newly diagnosed active pulmonary tuberculosis. |
### Instruction:
Is kIF14 messenger RNA expression independently prognostic for outcome in lung cancer?
### Response:
| KIF14 expression is independently prognostic for disease-free survival in lung cancer and knockdown decreases tumorigenicity in vitro, showing that it is a clinically relevant oncogene and an exciting therapeutic target for further study. |
### Instruction:
Is cytokeratin-18 a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy?
### Response:
| Induction of necrotic cell death may explain the clinical efficacy of anthracycline-based therapy for breast carcinomas with defective apoptosis pathways. We suggest that CK18 biomarkers are useful for early prediction of the response to CEF therapy in breast cancer and may be useful biomarkers for clinical trials. |
### Instruction:
Are changes of biochemical markers of bone turnover and YKL-40 following hormonal treatment for metastatic prostate cancer related to survival?
### Response:
| Serial monitoring of serum PINP, BAP, CTX-I, and YKL-40 in metastatic PC patients during hormonal treatment provided information of prognosis. |
### Instruction:
Is heart rate recovery lower following supine exercise in asymptomatic hereditary hemochromatosis subjects compared with healthy controls?
### Response:
| Heart rate recovery was not significantly different between HH and control subjects during upright exercise. However, HRR was significantly lower during SLEE in HH subjects compared with controls. A higher venous return during SLEE may have allowed for differences in arterial compliance between groups to influence HRR. |
### Instruction:
Is cycling efficiency compromised for moderate exercise in moderately severe COPD?
### Response:
| Findings suggest that bioenergetics of submaximal cycling is not compromised in moderately severe COPD despite tachypnea and dynamic hyperinflation. |
### Instruction:
Do dietary apple polyphenols enhance gastrocnemius function in Wistar rats?
### Response:
| We conclude that dietary APP enhance normal muscle function in Wistar rats. Alteration of lipid metabolism might be one of the mechanisms of this phenomenon. |
### Instruction:
Do isotope and patient age predict for PSA spikes after permanent prostate brachytherapy?
### Response:
| In low-risk prostate cancer, PSA spikes are most common in patients implanted with (125)I and/or <65 years of age. Differences in isotope-related spikes are most pronounced in hormone-naive patients. |
### Instruction:
Does intensity-modulated radiotherapy result in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy?
### Response:
| The use of IMRT in the treatment of the whole breast results in a significant decrease in acute dermatitis, edema, and hyperpigmentation and a reduction in the development of chronic breast edema compared with conventional wedge-based RT. |
### Instruction:
Does hyperglycemia regulate thioredoxin-ROS activity through induction of thioredoxin-interacting protein ( TXNIP ) in metastatic breast cancer-derived cells MDA-MB-231?
### Response:
| In this study we show that TXNIP is an oxidative stress responsive gene and its expression is exquisitely regulated by glucose level in highly metastatic MDA-MB-231 cells. |
### Instruction:
Does lower extremity muscle activation and alignment during the soccer instep and side-foot kick?
### Response:
| Certain lower extremity muscle groups face different demands during the soccer instep kick compared to the soccer side-foot kick. Similarly, the support limb muscles face different demands than the kicking limb during both kicks. Better definition of lower extremity function during kicking provides a basis for improved insight into soccer player performance, injury prevention, and rehabilitation. |
### Instruction:
Is circulating osteoprotegerin associated with age and systolic blood pressure , but not with lipid profile or fasting glucose , in postmenopausal women?
### Response:
| These results suggest that increased circulating OPG in postmenopausal women is closely related to higher systolic blood pressure, which could cause atherosclerosis. |
### Instruction:
Are filaggrin null mutations associated with increased asthma severity in children and young adults?
### Response:
| FLG mutations are associated not only with eczema-associated asthma susceptibility but also with asthma severity independent of eczema status. |
### Instruction:
Does dydrogesterone increase allopregnanolone in selected brain areas and in serum of female rats?
### Response:
| Dydrogesterone interacts with allopregnanolone levels (less with beta-endorphin), and it can be considered important modulator of the neuroendocrine function. |
### Instruction:
Are late-life depressive symptoms associated with both hyperactivity and hypoactivity of the hypothalamo-pituitary-adrenal axis?
### Response:
| Late-life depressive symptoms are associated with both hyperactivity and hypoactivity of the HPA axis, which suggests distinct mechanisms for these associations. |
### Instruction:
Is tobacco smoke exposure associated with attenuated endothelial function in 11-year-old healthy children?
### Response:
| Exposure to environmental tobacco smoke confirmed by serum cotinine concentrations impairs endothelial function in a dose-dependent manner in 11-year-old children. |
### Instruction:
Are length of gestation and gender associated with HLA genotypes at risk for Type 1 diabetes ( Italian DIABFIN 3 )?
### Response:
| Length of gestation is inversely correlated with HLA risk categories for T1D. The higher the HLA risk for T1D, the shorter the gestational age, especially in male neonates. |
### Instruction:
Is clinical biology of esophageal adenocarcinoma after surgery influenced by nuclear factor-kappaB expression?
### Response:
| Our data are the first to show that NF-kappaB status significantly correlates with DFS and OS for patients with esophageal adenocarcinoma undergoing surgery as primary therapy. NF-kappaB is an independent prognosticator of outcome, even for individual stages (e.g., stages II and III). More comprehensive molecular studies could help the design of strategies to individualize therapy of esophageal adenocarcinoma. |
### Instruction:
Does identification of platelet hyper-reactivity measured with a portable device immediately after percutaneous coronary intervention predict in stent thrombosis?
### Response:
| A CEPI-CT<190 s measured within the first 24 h following PCI predicts IST defined as the occurrence of death or MI. |
### Instruction:
Is repeat organic dust exposure-induced monocyte inflammation associated with protein kinase C activity?
### Response:
| Repeat organic dust exposure modulated inflammatory mediator production in monocytes independent of endotoxin. The inability of PKC to be reactivated may account for this observation. |
### Instruction:
Does trastuzumab prolong overall survival in patients with brain metastases from Her2 positive breast cancer?
### Response:
| Two parameters were significantly associated with prolonged OS: KPS and trastuzumab. While there was a trend towards prolonged TTP in patients with trastuzumab treatment after WBRT, this did not reach statistical significance. It appears therefore reasonable to suggest continuation of antibody therapy in patients with good performance status despite disease spreading to the brain. Concerning activity of trastuzumab in brain metastases themselves, no final conclusion is possible. |
### Instruction:
Are a decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus associated with behavioral and psychological symptoms in Alzheimer 's disease?
### Response:
| We conclude that BPSD and the decline in cognitive function in AD might have separate pathologies. |
### Instruction:
Is stereoacuity affected by induced phoria but returns toward baseline during vergence adaptation?
### Response:
| In these participants, inducing a deviation with base-out prisms negatively affected near stereoacuity. However, as adaptation occurred, the level of stereoacuity was seen to increase back toward the baseline measurement. |
### Instruction:
Does elastic plasma protein film blended with platelet releasate accelerate healing of diabetic mouse skin wounds?
### Response:
| Our results suggest that CPPP is a promising biologically active dressing for full-thickness skin wounds. CPPP can be an entirely autologous biological dressing, suggesting that it is free from the risk of transmission of pathogens through blood products. |
### Instruction:
Does clinical effect of buffy-coat vs. apheresis platelet concentrate in patients with severe thrombocytopenia after intensive chemotherapy?
### Response:
| We can conclude that BC PCs are not inferior to apheresis PCs, and may serve the clinical purposes as well as apheresis PCs harvested by Amicus. |
### Instruction:
Does balance module allow consistent monitoring and documentation of the pooling process for nucleic acid amplification technology testing?
### Response:
| With the novel liquid arrival check system, complete and consistent process documentation of pooling for nucleic acid amplification technology (NAT) testing is feasible. It enables blood banks to monitor and compare every single dispense made with predefined, required volumes. Results can be transferred to the laboratory information management system for automated selective exclusion of inaccurately dispensed samples. ONE SENTENCE SUMMARY: Monitoring and documenting the pooling process for NAT testing using a balance-based liquid arrival check system. |
### Instruction:
Does induction of cytochrome P450 2E1 [ corrected ] promote liver injury in ob/ob mice?
### Response:
| These results show that obesity contributes to oxidative stress and liver injury and that induction of CYP2E1 enhances these effects. |
### Instruction:
Do [ Specific small interfering RNAs inhibit replication of hepatitis B virus ]?
### Response:
| Specific siRNA can significantly inhibit protein expression and mRNA synthesis of HBV in HepG2.2.15 cells in vitro. |
### Instruction:
Is tacrolimus ointment more effective than pimecrolimus cream in adult patients with moderate to very severe atopic dermatitis?
### Response:
| Tacrolimus ointment is more effective than pimecrolimus cream in adults with moderate to very severe AD. Both agents have a similar safety profile. |
### Instruction:
Does free fluid in Morison 's pouch on bedside ultrasound predict need for operative intervention in suspected ectopic pregnancy?
### Response:
| Free intraperitoneal fluid found in Morison's pouch in patients with suspected ectopic pregnancy may be rapidly identified at the bedside by EP-performed US and predicts the need for operative intervention. |
### Instruction:
Is universal antenatal human immunodeficiency virus ( HIV ) testing programme cost-effective despite a low HIV prevalence in Hong Kong?
### Response:
| The universal antenatal testing programme in Hong Kong is largely efficient. In view of the low prevalence of HIV infection, high rates of HIV testing and uptake of antiretroviral prophylaxis are crucial to the success of the programme. |
### Instruction:
Does clinicopathological correlate in a cohort of Hong Kong breast cancer patients presenting with screen-detected or symptomatic disease?
### Response:
| The findings suggest a disturbingly low utilisation of mammography in Hong Kong patients, and raise the possibility of a more proactive public health approach to promote such screening for susceptible target groups. |
### Instruction:
Does carotid intraplaque hemorrhage detected by magnetic resonance imaging predict embolization during carotid endarterectomy?
### Response:
| Intraplaque hemorrhage as detected by carotid MRI predicts particulate embolization during the dissection phase of CEA. This imaging technique can be used to identify patients with increased intraoperative thromboembolic risk, and this could influence preventive strategies. |
### Instruction:
Does a required rural health module increase students ' interest in rural health careers?
### Response:
| A required community-based rural health course positively influences many medical students' reported intention toward rural practice and increases most students interest in rural health. Rural general practice placements are in short supply. This course offers valuable rural experience to students without depending significantly on GPs, but student feedback has increased efforts to make the course more clinically focussed. |
### Instruction:
Is a diverting stoma necessary when performing a handsewn coloanal anastomosis for lower rectal cancer?
### Response:
| The anastomotic complication rate was low even without a diverting stoma. This study suggests that a diverting stoma is not necessary when performing a handsewn coloanal anastomosis for lower rectal cancer however, an effort should be made for healthy anastomotic healing in patients with rectal cancer who are preoperatively radiated. |
### Instruction:
Does incomplete distal renal tubular acidosis affect growth in children?
### Response:
| Incomplete dRTA affects height in children. This observation needs validation in longitudinal studies. |
### Instruction:
Is long-term survival possible after stenting for malignant ureteric obstruction in colorectal cancer?
### Response:
| Long-term survival is possible in selected patients with recurrent or irresectable colorectal cancer and malignant ureteric obstruction. This appears to be more likely in those patients in whom other treatments, particularly chemotherapy, are available. |
### Instruction:
Does femoral shaft bowing influence the correction angle for high tibial osteotomy?
### Response:
| The correction angle by FTA for HTO should be calculated taking femoral and/or tibial shaft bowing in the frontal plane into account. |
### Instruction:
Does apoB C7623T polymorphism predict risk for steroid-induced osteonecrosis of the femoral head after renal transplantation?
### Response:
| For the prediction of ONFH, it is useful to analyze ApoB C7623T and plasma ApoB/ApoA1 ratio before the administration of steroids. |
### Instruction:
Does mechanical stretch simulate proliferation of venous smooth muscle cells through activation of the insulin-like growth factor-1 receptor?
### Response:
| Our results demonstrate for the first time that mechanical stretch activates IGF-1/IGF-1R signals in venous VSMCs, and we have uncovered a signaling pathway that leads to neointima formation in vivo. |
### Instruction:
Does [ Cromolyn sodium ameliorate rat left cardiac function during intestinal ischemia-reperfusion ]?
### Response:
| Cromolyn sodium can protect the myocardium against intestal ischemia-reperfusion injury and improve the cardiac function. |
### Instruction:
Is expression of RNA virus proteins by RNA polymerase II dependent expression plasmids hindered at multiple steps?
### Response:
| Insufficient cytoplasmic mRNA levels and premature polyadenylation prevent expression of RSV-F by RNA polymerase II dependent expression plasmids. Since RSV replicates in the cytoplasm, the presence of premature polyadenylation sites and elements leading to nuclear instability should not interfere with RSV-F expression during virus replication. The molecular mechanisms responsible for the destabilisation of the RSV-F and VSV-G mRNAs and the different requirements for their rescue by insertion of an intron remain to be defined. |
### Instruction:
Are hZip2 and hZip3 zinc transporters down regulated in human prostate adenocarcinomatous glands?
### Response:
| These results coupled with previous reports implicate Zip2 and Zip3 along with Zip1 as important zinc uptake transporters involved in the unique ability of prostate cells to accumulate high cellular zinc levels. Zip1 is important for the extraction of zinc from circulation as the primary source of cellular zinc. Zip 2 and Zip3 appear to be important for retention of the zinc in the cellular compartment. The down regulation of all three transporters in the malignant cells is consistent with the loss of zinc accumulation in these cells. Since zinc imposes tumor suppressor effects, the silencing of the gene expression for these transporters is a required event for the manifestation of the malignant activities of the neoplastic cells. This now provides new insights into the genetic/molecular events associated with the development of prostate cancer; and supports our concept of Zip1, and now Zip2 and Zip3, as tumor suppressor genes and zinc as a tumor suppressor agent. |
### Instruction:
Is heat shock protein gene 70-2 polymorphism differentially associated with the clinical phenotypes of ulcerative colitis and Crohn 's disease?
### Response:
| CD patients with BB genotype of HSP70-2 polymorphism tend to experience a more severe clinical course and allele A is associated with more severe UC. HSP70-2 polymorphism may be used to predict CD and UC phenotypes, which can illuminate immunological differences in CD and UC. |
### Instruction:
Does incidence and correlate of cesarean section in a capital city of a middle-income country?
### Response:
| This study shows an increased CS rate in a middle-income country, and identifies the correlates of women delivering by the abdominal route. These correlates may be used for effective reduction policies in the future. |
### Instruction:
Is relative cerebral blood volume a measure of angiogenesis in brain tuberculoma?
### Response:
| Relative cerebral blood volume is a measure of angiogenesis in the cellular fraction of the brain tuberculoma. This information may be of value in predicting the therapeutic response in future. |
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