Datasets:
typosonlr
/
PubMedPreProcessed

Dataset card Data Studio Files
xet
Community
1
question
stringlengths
52
373
long_answer
stringlengths
1
3.34k
### Instruction: Does indoleamine 2,3-dioxygenase inhibition alter the non-coding RNA transcriptome following renal ischemia-reperfusion injury? ### Response:
These results suggest a biologic role for non-coding, IDO-dependent genes in regulating the early response to IRI.
### Instruction: Does combined elevation of microRNA-196a and microRNA-196b in sera predict unfavorable prognosis in patients with osteosarcomas? ### Response:
Our present data indicate the involvement of miR-196a and miR-196b upregulation in the pathogenesis of osteosarcoma. More importantly, the altered levels of circulating miR-196a and miR-196b might have great potential to serve as novel and non-invasive prognostic factors for this malignancy.
### Instruction: Does benchmarking trauma centers on mortality alone reflect quality of care : implications for pay-for-performance? ### Response:
Mortality-based external benchmarking does not identify centers with high complication rates. This creates a dichotomy between current trauma center profiling standards and measures used for pay-for-performance. A benchmarking mechanism that reflects all measures of quality is needed.
### Instruction: Does a prenatal prediction model for total nucleated cell count increase the efficacy of umbilical cord blood banking? ### Response:
Our prenatal prediction model increases the efficacy of obtaining informed consent for UCB banking while still allowing relevant numbers of CBUs to be banked.
### Instruction: Does assessment of procedural skills using virtual simulation remain a challenge? ### Response:
Only the full procedure of the LAP Mentor procedural simulator has enough discriminative power to claim construct validity. However, the lack of quality control, which is indispensible in the evaluation of procedural skills, makes it currently unsuited for the assessment of procedural laparoscopic skills. The role of the simulator in a training context remains to be elucidated.
### Instruction: Does morus alba L. suppress the development of atopic dermatitis induced by the house dust mite in NC/Nga mice? ### Response:
Our results suggest that MAE has potent inhibitory effects on atopic dermatitis-like lesion and may be a beneficial natural resource for the treatment of atopic dermatitis.
### Instruction: Is nOX2-generated oxidative stress associated with severity of ultrasound liver steatosis in patients with non-alcoholic fatty liver disease? ### Response:
We demonstrated increased markers of oxidative stress in subjects with non-alcoholic fatty liver. Urinary 8-iso-PGF2α and serum soluble NOX2-derived peptide levels were independent from obesity, diabetes and metabolic syndrome and increased with the severity of liver steatosis at ultrasound.
### Instruction: Is preeclampsia in high risk women characterized by risk group-specific abnormalities in serum biomarkers? ### Response:
Patterns of serum biomarkers vary by high-risk group. These data support the hypothesis that multiple pathogenic pathways lead to the disease recognized clinically as preeclampsia.
### Instruction: Are mannose-binding lectin gene , MBL2 , polymorphisms associated with susceptibility to invasive pneumococcal disease in children? ### Response:
Defective MBL2 polymorphisms did not predict increased IPD susceptibility in children born in Northern Europe.
### Instruction: Does mALDI imaging on tissue microarrays identify molecular features associated with renal cell cancer phenotype? ### Response:
Our data pinpoint towards various molecules with potential relevance in renal cell cancer. They also demonstrate that the combination of the MALDI mass spectrometry imaging and large-scale tissue microarray platforms represents a powerful approach to identify clinically-relevant molecular cancer features.
### Instruction: Is formyl Peptide receptor 1 expression associated with tumor progression and survival in gastric cancer? ### Response:
FPR1 expression may be used as a novel indicator to predict outcome in GC patients after gastrectomy.
### Instruction: Does smokeless tobacco increase aneuploidy in oral HPV16 E6/E7-transformed keratinocytes in vitro? ### Response:
The effect of STE varied in the cell lines studied. STE2 increased significantly the proportion of aneuploid cells in HPV-positive oral keratinocytes, but not HPV16 E6/E7 expression. This indicates that tobacco products may enhance the effects of HPV 16 and the risk of DNA aneuploidy increasing risk to malignant transformation.
### Instruction: Does eGR1 support the osteogenic differentiation of dental stem cells? ### Response:
EGR1 supported the osteogenic differentiation of dental stem cells by potentially regulating the expression of DLX3 and BMP2.
### Instruction: Does metronomic oral paclitaxel show anti-tumor effects in an orthotopic mouse model of ovarian cancer? ### Response:
Metronomic oral chemotherapy with DHP107 showed anti-tumor efficacy in vivo similar to IP paclitaxel in an orthotopic mouse model.
### Instruction: Does activation of spinal NF-κB/p65 contribute to peripheral inflammation and hyperalgesia in rat adjuvant-induced arthritis? ### Response:
These findings indicate that spinal NF-κB/p65 plays an important role in the initiation and development of both peripheral inflammation and hyperalgesia. Thus, inhibition of spinal NF-κB/p65 expression may provide a potential treatment to manage painful inflammatory disorders.
### Instruction: Is endogenous myeloperoxidase a mediator of joint inflammation and damage in experimental arthritis? ### Response:
MPO contributes to the development of arthritis despite suppressing adaptive immunity in secondary lymphoid organs. This suggests distinct effects of local MPO on arthritogenic effector responses.
### Instruction: Does rebamipide suppress collagen-induced arthritis through reciprocal regulation of th17/treg cell differentiation and heme oxygenase 1 induction? ### Response:
The inhibitory effects of rebamipide on joint inflammation are associated with recovery from an imbalance between Th17 cells and Treg cells and with activation of an Nrf2/HO-1 antioxidant pathway.
### Instruction: Does long noncoding RNA related to cartilage injury promote chondrocyte extracellular matrix degradation in osteoarthritis? ### Response:
The results indicate that lncRNA-CIR contributes to ECM degradation and plays a key role in the pathogenesis of OA. We propose that lncRNA-CIR could be used as a potential target in OA therapy.
### Instruction: Does hIV Tat protein affect circadian rhythmicity by interfering with the circadian system? ### Response:
The HIV Tat protein affects circadian rhythmicity by interfering with the circadian system in patients with HIV/AIDS and further increases the melatonin excretion value. A Tat protein-related high melatonin value may counteract HIV-related poor sleep quality during the progression of HIV infection. This study provides the first clinical evidence offering an explanation for why sleep quality did not show an association with progression of HIV infection in previous studies.
### Instruction: Does provider awareness alone improve transition readiness skills in adolescent patients with inflammatory bowel disease? ### Response:
Increasing awareness around transition readiness for pediatric providers had an insignificant effect on the self-management skills of patients with IBD. A more formal or structured approach is likely required to improve transition skills in adolescent patients.
### Instruction: Do the effectiveness of four methods for stain removal from direct resin-based composite restorative materials? ### Response:
Compositions of resin-based composite resins play an important role in their susceptibility to stain and their amenability to stain removal procedures. Home bleaching showed good results for the three materials, while office bleach was the least effective.
### Instruction: Is time-domain T-wave alternans strongly associated with a history of ventricular fibrillation in patients with Brugada syndrome? ### Response:
Elevated time-domain TWA on AECG confirms arrhythmia risk in symptomatic BrS patients without the need for provocative stimuli.
### Instruction: Does analytical function for beta and gamma absorbed fractions of iodine-131 in spherical and ellipsoidal volumes? ### Response:
The analytical functions that we obtained from fitting process in Monte Carlo data can be used for obtaining the absorbed fractions of iodine-131 beta and gamma rays for any volume of the thyroid lobe. Moreover, our results for the spheres are in good agreement with the results of MIRD and other scientific literatures.
### Instruction: Do base excision repair defects invoke hypersensitivity to PARP inhibition? ### Response:
BER deficiency represents a new therapeutic opportunity to enhance PARPi efficacy.
### Instruction: Are subnormal levels of vitamin D associated with acute wheeze in young children? ### Response:
Our findings support the hypothesis that subnormal levels of vitamin D are associated with acute wheeze in young children.
### Instruction: Is the systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber independent of age and body size? ### Response:
The systemic exposure to the active ingredients of a fixed dose combination of beclometasone/formoterol administered via pMDI with AeroChamber Plus™ correlates with the nominal dose independently of patient age and body size. Thus, dose reduction in relation to age when using a pMDI with VHC may be unnecessary for reducing the systemic exposure in children.
### Instruction: Is active Transportation to and on Campus Associated With Objectively Measured Fitness Outcomes Among College Students? ### Response:
This study documents a relationship between AT behavior and objectively measured fitness among college students and provides a rationale for targeting this behavior as a method for improving health outcomes.
### Instruction: Do pseudomonas aeruginosa clinical and environmental isolates constitute a single population with high phenotypic diversity? ### Response:
Contrary to what has been described for other bacteria we have found that the P. aeruginosa core genome is constituted by a high proportion of genes and that its pan-genome is thus relatively small. Considering the high degree of genomic conservation between isolates of P. aeruginosa from diverse environments, including human tissues, some implications for the treatment of infections are discussed. This work also represents a methodological contribution for the genomic study of P. aeruginosa, since we provide a database of the comparison of all the proteins encoded by the seventeen strains analyzed.
### Instruction: Are gene-rich large deletions overrepresented in POAG patients of Indian and Caucasian origins? ### Response:
To our knowledge, our study is the first report on large CNV bias for gene-rich regions in glaucomatous neurodegeneration, implicating its impact across populations of contrasting ethnicities. We identified CNTN4 as a novel candidate gene for POAG.
### Instruction: Do ulcerative and nonulcerative forms of bladder pain syndrome/interstitial cystitis differ in symptom intensity or response to onabotulinum toxin A? ### Response:
In this cohort, Ulc and NUlc patients had similar symptoms at baseline and comparable clinical response to intratrigonal OnabotA. These findings suggest that pain may not be directly related with ulcers themselves.
### Instruction: Does factor V Leiden have a role in cryptogenic ischemic stroke among Iranian young adults? ### Response:
Based on our study, FVL might not be considered as an independent risk factor for ischemic stroke in Iranian individuals who are not suffering from other risk factors of ischemic stroke.
### Instruction: Does qT dispersion increase with low glomerular filtration rate in patients with coronary artery disease? ### Response:
QTd tends to be higher in patients with poor renal function independent of severity of angiographical CAD. QTd may be a potentially useful non-invasive test in the management of patients with poor renal function, especially those with CAD.
### Instruction: Does rNA sequencing identify novel markers of non-small cell lung cancer? ### Response:
CBX3 and CRABP2 expression was markedly increased in lung cancer tissues and especially CRABP2 may be promising candidate genes in lung adenocarcinoma.
### Instruction: Is hepatic encephalopathy associated with slowed and delayed stimulus-associated somatosensory alpha activity? ### Response:
The present results provide the first evidence for a slowing of oscillatory activity in the somatosensory system in HE in combination with a previously unknown deficit of S1 in adjusting activation levels back to baseline.
### Instruction: Does sulfhydration of p66Shc at cysteine59 mediate the antioxidant effect of hydrogen sulfide? ### Response:
H2S inhibits mitochondrial ROS production via the sulfhydration of Cys-59 residue, which in turn, prevents the phosphorylation of p66Shc.
### Instruction: Is hER-2 expression prognostic in osteosarcoma ; a Children 's Oncology Group prospective biology study? ### Response:
HER-2 expression is not prognostic in osteosarcoma in the context of this large prospective study. HER-2 expression cannot be used as a basis for stratification of therapy. Identification of potential prognostic factors should occur in the context of large multi-institutional biology studies.
### Instruction: Does shaoYao decoction ameliorate colitis-associated colorectal cancer by downregulating proinflammatory cytokines and promoting epithelial-mesenchymal transition? ### Response:
SYD ameliorates caCRC by suppressing inflammation and inhibiting EMT. SYD might be an alternative therapy for caCRC.
### Instruction: Does gestational diabetes mellitus alter apoptotic and inflammatory gene expression of trophobasts from human term placenta? ### Response:
Maternal GDM results in heavier placentas with aberrant placental apoptotic and inflammatory gene expression that may account, at least partially, for macrosomia in newborns.
### Instruction: Are antihelminthic benzimidazoles novel HIF activators that prevent oxidative neuronal death via binding to tubulin? ### Response:
These studies demonstrate that tubulin-binding drugs can activate a component of the hypoxic adaptive response, specifically the stabilization of HIF-1α and its downstream targets. Tubulin-binding drugs, including antihelminthic benzimidazoles, also abrogate oxidative neuronal death in primary neurons. Given their safety in humans and known ability to penetrate into the central nervous system, antihelminthic benzimidazoles may be considered viable candidates for treating diseases associated with oxidative neuronal death, including stroke.
### Instruction: Does microRNA-181a promote tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1? ### Response:
Our data demonstrate that miR-181a expression is associated with CRC liver metastasis and survival. miR-181a has strong tumor-promoting effects through inhibiting the expression of WIF-1, and its potential role in promoting epithelial-mesenchymal transition.
### Instruction: Does inhibition during early adolescence predict alcohol and marijuana use by late adolescence? ### Response:
Compromised inhibitory functioning during early adolescence prior to the onset of substance use was related to more frequent and intense alcohol and marijuana use by late adolescence. Inhibition performance could help identify teens at risk for initiating heavy substance use during adolescence, and potentially could be modified to improve outcome.
### Instruction: Does miRNA-26b inhibit cellular proliferation by targeting CDK8 in breast cancer? ### Response:
These findings suggest that miR-26b exerts a tumor suppressive role in breast cancer and the miR-26b-mediated growth inhibition is achieved through suppression of a new target gene CDK8.
### Instruction: Are activation of circulated immune cells and inflammatory immune adherence involved in the whole process of acute venous thrombosis? ### Response:
Acute venous thrombosis is an activation process of circulated lymphocytes, neutrophils and platelets mainly, and a whole process including integrin subunit β2 and β3 binding with their ligands. Activation of immune cells, inflammatory immune adherence and coagulation response are involved in the acute venous thrombosis.
### Instruction: Does flurbiprofen improve dysfunction of T-lymphocyte subsets and natural killer cells in cancer patients receiving post-operative morphine analgesia? ### Response:
The combination of morphine and flurbiprofen ameliorates the immune depression in Tlymphocyte subsets and natural killer cells and provides a similar analgesic efficacy to morphine alone in patients undergoing gastric cancer surgery.
### Instruction: Are human adipocytes highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression? ### Response:
Human adipocytes demonstrate strong sensitivity to inflammatory gene expression in response to acute IH and hence, adipose tissue may be a key source of inflammatory mediators in OSA.
### Instruction: Does increasing functional variability in the preparatory phase of the takeoff improve elite springboard diving performance? ### Response:
Results suggested that on completion of training, athletes were capable of successfully adapting their movement patterns under more varied takeoff conditions to achieve greater consistency and stability of performance outcomes.
### Instruction: Are anticytomegalovirus antibody titres associated with caregiving burden in younger caregivers? ### Response:
These data suggest that in the absence of immunosenescence, the chronic stress of caregiving is not sufficient to compromise the immune response to persistent CMV infection. However, an indirect mechanism to poorer health in caregivers might be via adoption of disadvantageous health behaviours in response to stress. Statement of contribution What is already known on this subject? Older caregivers of spouses with dementia show a poorer immune response against latent viruses when compared to age- and sex-matched controls. Younger parental caregivers of children with developmental disabilities show a poorer antibody response to vaccination. What does this study add? The study showed no association between caregiving stress and CMV antibody titre in young caregivers. There were higher CMV antibody titres in the caregivers who engage in unhealthy behaviours.
### Instruction: Is maternal sleep duration and complaints of vital exhaustion during pregnancy associated with placental abruption? ### Response:
We extend the existing literature and support the thesis that maternal sleep habits and disorders should be assessed among pregnant women.
### Instruction: Is the passage of meconium alone a sign of correctly positioned anus? ### Response:
The passage of meconium is not the only sign of correctly positioned anus. A careful physical examination and awareness of this anomaly are of great importance in making a timely diagnosis of anorectal malformations.
### Instruction: Is endocan useful biomarker of survival and severity in sepsis? ### Response:
Results of our study show that endocan can be used as strong and significant predictor of sepsis severity and outcome, perhaps even better than SOFA and APACHE II scores.
### Instruction: Does hepatocyte nuclear factor 4α-nuclear factor-κB feedback circuit modulate liver cancer progression? ### Response:
Collectively, an HNF4α-NF-κB feedback circuit including miR-124, miR-7, and miR-21 was identified in HCC, and the combination of HNF4α and NF-κB exhibited more powerful predictive efficiency of patient prognosis. These findings broaden the knowledge of hepatic inflammation and cancer initiation/progression, and also provide novel prognostic biomarkers and therapeutic targets for HCC.
### Instruction: Do intraoperative measurement for a new transcutaneous bone conduction hearing implant? ### Response:
The usage of an intraoperative RTF measurement may be a good method to verify the mechanical coupling of the bone conduction floating mass transducer and to test the functional integrity of the implant in an objective way.
### Instruction: Does [ Sanhuangyinchi decoction pretreatment ameliorate acute hepatic failure in rats by suppressing antioxidant stress and caspase-3 expression ]? ### Response:
SHYCD pretreatment can dose-dependently ameliorate AHF in rats possibly by suppressing antioxidant stress and caspase-3 expression to decrease hepatic cell apoptosis.
### Instruction: Does [ 1,25-dihydroxyvitamin D3 pretreatment inhibit house dust mite-induced thymic stromal lymphopoietin release by human airway epithelial cells ]? ### Response:
Both 1,25VD3 and HDM can induce TSLP expression and release in 16HBE cells, but pretreatment with 1,25VD3 can decrease HDM-augmented TSLP expression in the cells.
### Instruction: Does [ SCF/c-Kit signaling promote invasion of T24 cells via PI3K pathway ]? ### Response:
SCF/c-Kit signaling promotes the invasiveness of T24 cells, and this effect is mediated by the PI3K pathway.
### Instruction: Does [ Serum follicle-stimulating hormone in combination with serum inhibin B evaluate spermatogenesis of azoospermic men ]? ### Response:
Serum FSH and INHB levels is ineffective to distinguish the spermatogenic classifications from azoospermic men, but they are available to confirm the disease of Sertoli cell only. The other abnormalities of azoospermic men is also dependent on bioptic histopathology to confirm the subtypes.
### Instruction: Does highly prevalent SERPINB7 founder mutation cause pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis? ### Response:
These data clearly provide further evidence that NPPK is caused by loss-of-function mutations in SERPINB7.
### Instruction: Do augmentative therapies potentiate the antidepressant-like effects of deep brain stimulation in rats? ### Response:
Despite having good predictive validity, animal models are limited from a translational perspective.
### Instruction: Does both body weight and BMI predict improvement in symptom and functioning for patients with major depressive disorder? ### Response:
This is a short-term trial with relatively small sample size.
### Instruction: Is density and duration of pneumococcal carriage maintained by transforming growth factor β1 and T regulatory cells? ### Response:
These data explain the mechanisms by which S. pneumoniae colonize the human nasopharynx without inducing damaging host inflammation and provide insight into the role of bacterial and host constituents that allow and maintain carriage.
### Instruction: Does chronic stress impair GABAergic control of amygdala through suppressing the tonic GABAA receptor currents? ### Response:
Our study suggests that enduring loss of tonic but not phasic GABAAR currents critically contributes to the prolonged amygdala disinhibition subsequent to chronic stress. We propose that the preferential loss of tonic inhibition may account for the development of stress-related neuropsychiatric diseases.
### Instruction: Do brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke? ### Response:
The results support the notion of a predominant role of brainstem injury in the development of RBD and suggest that patients with brainstem infarcts RBD should be evaluated by a clinical neurologist.
### Instruction: Does severe hypoxia exert parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells? ### Response:
We conclude that severe hypoxia confers a quiescent phenotype in hMSCs that is reflected by both the transcriptome profile and gene-specific changes of splicosome actions. The results reveal that severe hypoxia imposes markedly different patterns of gene regulation of MSCs compared with more moderate hypoxia. This is the first study to report hypoxia-regulation of AS in stem/progenitor cells and the first molecular genetic characterization of MSC in a hypoxia-induced quiescent immobile state.
### Instruction: Does impact of postoperative renal replacement therapy on long-term outcome after cardiac surgery increase with age? ### Response:
Patients requiring RRT after cardiac surgery have a poor prognosis with a high mortality. Older age predicted both 30-day and late mortality in these patients.
### Instruction: Does collaborative DTM reduce hospitalization and healthcare costs in patients with diabetes treated with polypharmacy? ### Response:
A collaborative pharmacist-driven DTM program with a care manager-executed patient outreach component results in reduced hospital utilization and significant healthcare cost savings.
### Instruction: Does tetanus toxin reduce local and descending regulation of the H-reflex? ### Response:
Tetanus toxin increased the amplitude of the Hwave and reduced the normal depression of H-wave amplitude that is associated with closely timed stimuli, two phenomena that could contribute to hyperactivity of the stretch reflex.
### Instruction: Is arterial blood pressure closely related to ascites development in compensated HCV-related cirrhosis? ### Response:
The MAP is closely related to the development of ascites in compensated HCV-related cirrhosis. The risk of ascites development increases in 4.4 fold for subjects with MAP values <83.32 mm/Hg.
### Instruction: Is evidence that the lung Adenocarcinoma EML4-ALK fusion gene caused by exposure to secondhand tobacco smoke during childhood? ### Response:
The EML4-ALK fusion gene is not enriched in tumors from individuals exposed to SHS during childhood.
### Instruction: Are genetic variants in microRNA machinery genes associated [ corrected ] with idiopathic recurrent pregnancy loss risk? ### Response:
Our study demonstrates the relationship between RPL development and the polymorphism of the miRNA machinery gene RAN and combined genotype of DROSHA/DICER.
### Instruction: Is collagen type III alpha 1 polymorphism ( rs1800255 , COL3A1 2209 G > A ) assessed with high-resolution melting analysis associated with pelvic organ prolapse in the Dutch population? ### Response:
The previously found statistically significant association between the rs1800255, COL3A1 2209 G>A polymorphism as measured with PCR-RFLP and POP could no longer be demonstrated. This raises concerns regarding the results of other association studies using PCR-RFLP.
### Instruction: Is severe malarial anemia associated with long-term neurocognitive impairment? ### Response:
In children <5 years of age, SMA is associated with long-term impairment in cognitive ability, whereas CM is associated with additional impairment in the areas of attention and associative memory. SMA may be a major contributor to long-term neurocognitive impairment in children in sub-Saharan Africa.
### Instruction: Do neural responses to exclusion predict susceptibility to social influence? ### Response:
These results address the neural bases of social influence and risk taking; contribute to our understanding of social and emotional function in the adolescent brain; and link neural activity in specific, hypothesized, regions to risk-relevant outcomes beyond the neuroimaging laboratory. Results of this investigation are discussed in terms of the mechanisms underlying risk taking in adolescents and the public health implications for adolescent driving.
### Instruction: Is viral infection uncommon in adult patients with severe hospital-acquired pneumonia? ### Response:
Viral pathogens are not uncommon in adult patients with severe HAP who required ICU admission. Since viral pathogens may cause severe HAP and could be a potential source of viral transmission, further investigation is required to delineate the role of viral pathogens in severe HAP.
### Instruction: Is proteinuria testing among patients with diabetes mellitus associated with bladder cancer diagnosis : potential for unmeasured confounding in studies of pioglitazone and bladder cancer? ### Response:
Proteinuria testing may be a confounder in studies of pioglitazone and bladder cancer but does not fully explain the association between pioglitazone and bladder cancer in this cohort. Optimal adjustment for proteinuria testing likely requires knowledge of the test result.
### Instruction: Does survey of sonoanatomic distances for lumbar medial branch nerve block in healthy volunteers? ### Response:
We found many anatomic distances which may increase awareness of US guided LMBB.
### Instruction: Does margaritaria discoidea ( Euphorbiaceae ) stem bark extract attenuate allergy and Freund 's adjuvant-induced arthritis in rodents? ### Response:
Margaritaria discoidea suppresses allergy and exhibits anti-inflammatory activity in mice. In addition it attenuates Freund's adjuvant-induced arthritis through a reduction in serum levels of TNFα and IL-6 in rats.
### Instruction: Is stromal transforming growth factor-beta 1 crucial for reinforcing the invasive potential of low invasive cancer? ### Response:
Stromal TGF-β1 signalling promoted PDPN expression in cancer cells, thereby enhancing tumour growth and leading to a more invasive phenotype.
### Instruction: Does eGF reverse multi-drug resistance via the p-ERK pathway in HepG2/ADM and SMMC7721/ADM hepatocellular carcinoma models? ### Response:
EGF might enhance the chemosensitivity of HepG2/ADM and SMMC7721/ADM cells via up-regulating p-ERKs and BimEL protein.
### Instruction: Does psychiatric staff on the wards share attitudes on aggression? ### Response:
Psychiatric staff on the wards does not share attitudes on aggression. As each staff member has his/her own opinion about aggression, training for dealing with aggression or violent incidents should be done, at least partly, on an individual level. We also suggest caution in using the concept of ward culture as an explanation for the use of restrictive measures on psychiatric wards.
### Instruction: Do fcγ receptor III and Fcγ receptor IV on macrophages drive autoimmune valvular carditis in mice? ### Response:
FcγRIII and FcγRIV act redundantly to promote valvular carditis in K/BxN mice with systemic autoantibody-associated arthritis. Macrophage depletion reduced the severity of valve inflammation. These findings suggest that pathogenic autoantibodies engage Fcγ receptors on macrophages to drive valvular carditis. Our study provides new insight into the pathogenesis of cardiovascular inflammation in the setting of autoantibody-associated chronic inflammatory diseases.
### Instruction: Do aM-PAC `` 6-Clicks '' functional assessment scores predict acute care hospital discharge destination? ### Response:
Limitations included lack of information on the rater reliability of "6-Clicks" instruments, use of surrogate data for some discharge designations, and use of a clinical database for research purposes.
### Instruction: Does proteomic analysis reveal novel proteins associated with progression and differentiation of colorectal carcinoma? ### Response:
Their functional networks were analyzed by Ingenuity systems Ingenuity Pathways Analysis and revealed the potential roles as novel biomarkers for progression in various differentiation stages of CRC.
### Instruction: Does omentin prevent myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms? ### Response:
Our data indicate that omentin functions as an adipokine that ameliorates acute ischemic injury in the heart by suppressing myocyte apoptosis through both AMPK- and Akt-dependent mechanisms.
### Instruction: Are hyperglycemia , hypoglycemia , and glycemic complexity associated with worse outcomes after surgery? ### Response:
We found that hypoglycemia (glucose<71 mg/dL) and hyperglycemia (glucose>140 mg/dL) were associated with increased risk of complications, whereas greater complexity of the glucose time series was associated with mortality.
### Instruction: Does the Intermountain Risk Score predict mortality in trauma patients? ### Response:
Intermountain Risk Score strongly predicts mortality in trauma patients at this single level I trauma center. The ability to accurately determine a patient's mortality risk at admission makes IMRS a potentially clinically important tool.
### Instruction: Is cytoplasmic YAP expression associated with prolonged survival in patients with lung adenocarcinomas and epidermal growth factor receptor tyrosine kinase inhibitor treatment? ### Response:
High cytoplasmic YAP expression predicted a good clinical outcome for patients with lung adenocarcinoma and in EGFR-TKI-treated patients. Therefore, YAP may play a role in EGFR-TKI-treated lung cancer, and YAP targeting may enhance therapeutic effects in combination with other cancer drugs.
### Instruction: Does frequency of mealtime insulin bolus predict glycated hemoglobin in youths with type 1 diabetes? ### Response:
In a prospective, longitudinal design, youths' BOLUS scores were superior to youths' daily BGM in predicting future values of HbA1c. Calculating a BOLUS score versus BGM can help researchers and clinicians achieve a better prediction of youths' HbA1c.
### Instruction: Is isatis canescens a rich source of glucobrassicin and other health-promoting compounds? ### Response:
I. canescens flower buds represent a naturally rich source of GBS, at a level suitable for its purification. Furthermore, flower bud consumption could provide an intake of health-promoting compounds, with possible antioxidant and chemopreventive properties.
### Instruction: Does comorbidity influence multiple aspects of well-being of patients with ischemic heart disease? ### Response:
This study showed a consistent pattern of associations between somatic comorbidities and multiple aspects of well-being among patients with IHD. Findings may increase cardiologists' interest to identify and treat somatic conditions among IHD patients.
### Instruction: Is the effect of Rho kinase inhibition on long-term keratinocyte proliferation rapid and conditional? ### Response:
ROCK inhibition rapidly and conditionally induces indefinite proliferation of keratinocytes. This method has far-reaching applications for basic research, as well as for regenerative and personalized medicine.
### Instruction: Does hypoxia augment the calcium-activated chloride current carried by anoctamin-1 in cardiac vascular endothelial cells of neonatal mice? ### Response:
Ano1 formed CaCC in CVECs of neonatal mice. Hypoxia enhances Ano1-mediated ICl ( C a) density via increasing its expression, altering the ratio of its splicing variants, sensitivity to membrane voltage and to Ca(2+) . Ano1 may play a role in the pathophysiological processes during ischaemia in heart, and therefore, Ano1 might be a potential therapeutic target to prevent ischaemic damage.
### Instruction: Do matrix metalloproteinase-8 inhibitors mitigate sepsis-induced myocardial injury in rats? ### Response:
MMP-8 inhibitor attenuated myocardial injury in septic rats, which might be related to reduced expression of TNF-α and IL-1β.
### Instruction: Does metformin ameliorate insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3? ### Response:
Upregulated SIRT3 is involved in the pharmacological mechanism by which metformin promotes glucose uptake. Additionally, SIRT3 may function as an important regulator of oxidative stress and a new alternative approach for targeting insulin resistance-related diseases.
### Instruction: Does theanine improve the function of dendritic cells via the downregulation of cyclooxygenase-2 expression? ### Response:
Theanine inhibits the transcription and translation of COX-2 and regulates the balance of IL-10/IL-12 secretion in bombesin-inhibited DCs, leading to the recovery of a state of activation in DCs.
### Instruction: Does optic nerve crush induce spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice? ### Response:
A number of detrimental gene expression changes occur that contribute to trauma-induced neurodegeneration after injury to ON axons. Nrn1 (synaptic plasticity gene), Synpr and Syt1 (synaptic vesicle fusion genes), and Vsnl1 (neuron differentiation associated gene) were a few of the potentially unique genes identified that were down-regulated spatially and temporally in our rodent ONC model. Bioinformatic meta-analysis identified significant tissue-specific and time-dependent gene clusters associated with regenerative changes, synaptic plasticity, axonogenesis, neuron projection, and neuron differentiation. These ONC induced neuronal loss and regenerative failure associated clusters can be extrapolated to changes occurring in other forms of CNS trauma or in clinical neurodegenerative pathological settings. In conclusion, this study identified potential therapeutic targets to address two key mechanisms of CNS trauma and neurodegeneration: neuronal loss and regenerative failure.
### Instruction: Is cardiopulmonary exercise testing more accurate than ECG-stress testing in diagnosing myocardial ischemia in subjects with chest pain? ### Response:
In patients with chest pain, CPET showed a better diagnostic and predictive accuracy than traditional ET to detect/exclude myocardial ischemia. Its use should be encouraged among physicians as a first line diagnostic tool in clinical practice.
### Instruction: Does long-term reduction of T-cell intracellular antigens lead to increased beta-actin expression? ### Response:
Collectively, these results suggest that TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells.
### Instruction: Does epigenome-wide DNA methylation assay reveal placental epigenetic markers for noninvasive fetal single-nucleotide polymorphism genotyping in maternal plasma? ### Response:
The present studies systematically identified hypermethylated sites in fetal tissues and preliminarily demonstrated that some of the fetal epigenetic markers that contain informative SNPs have great potential for noninvasive fetal genetic diagnosis.
### Instruction: Does notch pathway target proangiogenic regulator Sox17 to restrict angiogenesis? ### Response:
Our findings demonstrate that the Notch pathway restricts sprouting angiogenesis by reducing the expression of proangiogenic regulator Sox17.
### Instruction: Does hemodynamic disturbed flow induce differential DNA methylation of endothelial Kruppel-Like Factor 4 promoter in vitro and in vivo? ### Response:
Hemodynamics influence endothelial KLF4 expression through DNMT enrichment/myocyte enhancer factor-2 inhibition mechanisms of KLF4 promoter CpG methylation with regional consequences for atherosusceptibility.