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### Instruction: Do [ Quick identification and discrimination of sun-dried and sulfur-fumigated cimicifugae rhizoma by Fourier transform infrared spectroscopy ]? ### Response:
The FTIR method combined with the second derivative IR spectrum can be used to analyze and distinguish sun-dried and sulfur-fumigated Cimicifugae Rhizoma quickly and accurately. The developed method provides an efficient approach for the quality control of Chinese herbal medicines with its simplicity and strong specificity.
### Instruction: Do early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair? ### Response:
Early postzygotic mutations constitute a substantial proportion of de novo mutations in humans. Therefore, genome mosaicism resulting from early mitotic events during embryogenesis is common and could substantially contribute to the development of diseases.
### Instruction: Is routine pathology evaluation of hydrocele and spermatocele specimens associated with significant costs and no identifiable benefit? ### Response:
No malignancy was detected in 159 hydrocele and spermatocele specimens during the 14 study years, suggesting that the pathology analysis is of little clinical benefit. Forgoing surgical pathology analysis of these specimens would result in significant cost savings to the patient and the health care system.
### Instruction: Does opioid use after fracture surgery correlate with pain intensity and satisfaction with pain relief? ### Response:
After operative fracture treatment, patients who take more opioids report greater pain intensity and less satisfaction with pain relief. Greater self-efficacy was the best determinant of satisfaction with pain relief. Evidence-based interventions to increase self-efficacy merit additional study for the management of postoperative pain during recovery from a fracture.
### Instruction: Are blood biomarkers helpful in the prediction of response to chemoradiation in rectal cancer : a prospective , hypothesis driven study on patients with locally advanced rectal cancer? ### Response:
CEA and IL-8 were identified as predictive biomarkers for tumor response and PCR after CRT in rectal cancer. Incorporation of these blood biomarkers leads to an additional accuracy of earlier developed prediction models using clinical variables and PET-information. The new model could help to an early adaptation of treatment in rectal cancer patients.
### Instruction: Are genetic variants in inducible nitric oxide synthase gene associated with the risk of radiation-induced lung injury in lung cancer patients receiving definitive thoracic radiation? ### Response:
Our results demonstrate that genetic variants of NOS2 may serve as a reliable predictor of RILI in lung cancer patients treated with thoracic radiation.
### Instruction: Is the positive influence of methotrexate on the mortality of patients with rheumatoid arthritis partly independent of its effect on disease activity : results of a re-evaluation 18 years after baseline? ### Response:
In this cohort, the mortality lowering effect of continued MTX use was partly independent of its effect on disease activity. This finding may affect treatment decisions concerning RA patients with insufficient response to MTX.
### Instruction: Does methylglyoxal impair endothelial insulin sensitivity both in vitro and in vivo? ### Response:
MGO impairs the action of insulin on the endothelium both in vitro and in vivo, at least in part through an ERK1/2-mediated mechanism. These findings may be instrumental in developing novel strategies for preserving endothelial function in diabetes.
### Instruction: Is transsulfuration an active pathway for cysteine biosynthesis in Trypanosoma rangeli? ### Response:
These findings demonstrate that the RTS pathway is active in T. rangeli, suggesting that this may be the only pathway for cysteine biosynthesis in this parasite. In this sense, the RTS pathway appears to have an important functional role during the insect stage of the life cycle of this protozoan parasite.
### Instruction: Does dehydration affect spinal cord cross-sectional area measurement on MRI in healthy subjects? ### Response:
Dehydration can confound CSA measurements on MRI. The magnitude of the effect is significant relative to short-term pathological changes that have been observed in diseases such as multiple sclerosis.
### Instruction: Is mean platelet volume associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus? ### Response:
This study has shown that an increased MPV is closely associated with poor glycaemic control, which may be a risk factor for diabetic retinopathy. Nonetheless, further prospective studies are needed to assess the relationship between MPV, glycaemic indices and microvascular complications.
### Instruction: Is younger age associated with lower reactive hyperemic index but not lower flow-mediated dilation among children and adolescents? ### Response:
Younger age is associated with lower RHI but not lower FMD among children and adolescents. These findings call into question the validity and usefulness of digital reactive hyperemia as a method to quantify endothelial function among younger children.
### Instruction: Is low serum bilirubin concentration a predictor of chronic kidney disease? ### Response:
Our study demonstrated that serum total bilirubin concentration could be a novel risk factor for the progression of CKD, defined as eGFR <60 ml/min/1.73 m(2), in the general population.
### Instruction: Is repeated introperative cholangiography helpful for donor safety in the procurement of right liver graft with supraportal right bile duct variants in living-donor liver transplantation? ### Response:
Repeated IOC is suggested as a routine for variants of supraportal right bile ducts especially trifurcation pattern in graft procurement to avoid the injury of donor remnant bile ducts.
### Instruction: Is growth in preterm infants until 36 weeks ' postmenstrual age close to target recommendations? ### Response:
Despite achieving a protein and energy intake close to the described target intake, the rate of growth in our infants was lower than indicated by the intrauterine growth curve. Lower gestational age, lower birth weight and severe illness had a negative effect on growth.
### Instruction: Is transient intrauterine fluid accumulation not due to hydrosalpinx or any identifiable pelvic pathology detrimental to IVF outcome? ### Response:
Transient IUFA not due to hydrosalpinx or any identifiable pelvic pathology has no detrimental effect on IVF pregnancy rates. Hence, cycle cancellation should be avoided in such cycles.
### Instruction: Is down regulation of miR-143 related with tumor size , lymph node metastasis and HPV16 infection in cervical squamous cancer? ### Response:
Down-regulated miR-143 is related with tumor size, lymph node metastasis and HPV16 infection in cervical SCC, but miR-143 does not participate in the Taxol sensitivity response.
### Instruction: Does video education provide effective wound care instruction pre- or post-mohs micrographic surgery? ### Response:
Video education prior to or post-Mohs surgery serves as an effective mechanism for patient education and improvement of time management in clinical practice.
### Instruction: Do [ Effects of continuous positive airway pressure treatment of inflammatory factors in patients with overlap syndrome ]? ### Response:
CPAP treatment significantly reduces the serum levels of CRP and TNF-α so as to improve inflammation responses in OS and OSAS patients.
### Instruction: Is tumour-initiating capacity independent of epithelial-mesenchymal transition status in breast cancer cell lines? ### Response:
Epithelial-mesenchymal transition does not alter tumour-initiating capacity of breast cancer cells but some other biological characteristics. Therefore, EMT and tumour-initiating capacity may not be directly linked in breast cancer cell lines.
### Instruction: Does rutin protect against cognitive deficits and brain damage in rats with chronic cerebral hypoperfusion? ### Response:
Our results provide new insights into the pharmacological actions of rutin and suggest that rutin has multi-targeted therapeutical potential on cognitive deficits associated with conditions with chronic cerebral hypoperfusion such as vascular dementia and Alzheimer's disease.
### Instruction: Are starch biosynthetic genes and enzymes expressed and active in the absence of starch accumulation in sugar beet tap-root? ### Response:
Considering underground storage organs, sugar beet tap-root upholds a unique property in exclusively storing sucrose. Lack of starch also in the ancestor sea beet indicates an evolved trait of biological importance.Our findings in this study show that gene expression and enzymatic activity of main starch biosynthetic functions are present in sugar beet tap-root during storage accumulation. In view of this, the complete lack of starch in sugar beet tap-roots is enigmatic.
### Instruction: Is conventional cytology beneficial for predicting peritoneal recurrence after curative surgery for gastric cancer : results of a prospective clinical study? ### Response:
Peritoneal washing cytology using samples harvested from two different sites in the abdominal cavity was not able to predict peritoneal recurrence or survival in gastric cancer patients. Further studies will be required to determine whether peritoneal washing cytology during gastric cancer surgery is a meaningful procedure.
### Instruction: Does toll-like receptor 2/4 heterodimer mediate inflammatory injury in intracerebral hemorrhage? ### Response:
Our results suggest that a novel TLR2/TLR4 heterodimer induced by Hb initiates inflammatory injury in ICH. Interfering with the assembly of the TLR2/TLR4 heterodimer may be a novel target for developing effective treatment of ICH.
### Instruction: Are bacteriocin-encoding genes and ExPEC virulence determinants associated in human fecal Escherichia coli strains? ### Response:
The occurrence of bacteriocin-encoding genes and ExPEC virulence determinants correlate positively in E. coli strains of human fecal origin. Bacteriocin synthesis appears to modulate the ability of E. coli strains to reside in the human intestine and/or the virulence of the corresponding strains.
### Instruction: Do momentary negative moods and being with friends precede cigarette use among Korean American emerging adults? ### Response:
Unlike more established smokers, these younger smokers may be strongly influenced by peer contexts as well as unpleasant affect. The interaction between social contexts and NA highlights a potential window for intervention for the population of KAEA smokers.
### Instruction: Is red cell distribution width increased in patients with ascending aortic dilatation? ### Response:
In patients with AAD, RDW and hs-CRP levels are increased, which may indicate the role of inflammation in the pathogenesis of AAD.
### Instruction: Does weak evidence support the short-term benefits of orthopaedic treatment for Class III malocclusion in children? ### Response:
There is some evidence that the use of a facemask to correct prominent lower front teeth in children is effective when compared to no treatment on a short-term basis. However, in view of the general poor quality of the included studies, these results should be viewed with caution. Further randomised controlled trials with long follow-up are required.
### Instruction: Do radiotherapy associated with higher rates of dental implant loss? ### Response:
Irradiation of the head was linked to increased failure rate of implants compared to failure rates in patients who had not undergone radiotherapy. The failure rate was higher in the maxilla and HBO therapy did not improve implant survival.
### Instruction: Do effectiveness of disinfection therapies and promotion of osteoblast growth on osseotite and nanotite implant surfaces? ### Response:
The Nanotite implant discs were the most difficult to disinfect, likely because of their chemical and physical properties. Citric acid and tetracycline were most effective for disinfecting the Osseotite implant discs, and further clinical research is needed to verify these effects in vivo. The Nd:YAG laser was the weakest disinfection method, and it is not recommended for disinfecting implant surfaces until its effectiveness is improved.
### Instruction: Is modified sequential Helicobacter pylori eradication therapy using high dose omeprazole and amoxicillin in the initial phase in the extensive metaboliser Turkish patients for CYP2C19 polymorphism ineffective? ### Response:
This modified high-dose sequential therapy was ineffective in a Turkish sample, nearly all of whom had EM in terms of CYP2C19 gene status.
### Instruction: Do residual neural processing of musical sound features in adult cochlear implant users? ### Response:
-Automatic brain responses to musical feature changes reflect the limitations of central auditory processing in adult Cochlear Implant users.-The brains of adult CI users automatically process sound features changes even when inserted in a musical context.-CI users show disrupted automatic discriminatory abilities for rhythm in the brain.-Our fast paradigm demonstrate residual musical abilities in the brains of adult CI users giving hope for their future rehabilitation.
### Instruction: Does ultraviolet B light attenuate the systemic immune response in central nervous system autoimmunity? ### Response:
Local UVB radiation of the skin influences systemic immune reactions and attenuates systemic autoimmunity via the induction of skin-derived tolerogenic DCs and Tregs. Our data could have implications for the understanding or therapeutic modulation of environmental factors that influence immune tolerance.
### Instruction: Is the mechanical fibrillation pattern of the atrial myocardium associated with acute and long-term success of electrical cardioversion in patients with persistent atrial fibrillation? ### Response:
Higher atrial fibrillatory wall velocities and longer AFCLs determined by echocardiography are associated with acute and long-term success of ECV.
### Instruction: Do retrospective analysis of facial dog bite injuries at a Level I trauma center in the Denver metro area? ### Response:
Availability of the plastic surgery service at a Level I trauma center is vital for the optimal treatment of facial dog bite injuries. Direct repair and reconstruction of facial dog bite injuries at the earliest opportunity resulted in good outcomes as evidenced by the satisfaction survey data and low complication rate.
### Instruction: Does levothyroxine therapy before brain death declaration increase the number of solid organ donations? ### Response:
The early use of LT and aggressive blood product resuscitation was associated with a significantly higher number of solid organs donated per donor. Earlier use of LT before the declaration of brain death may be considered in potential organ donors.
### Instruction: Is preinjury ambulatory status associated with 1-year mortality following lateral compression Type I fractures in the geriatric population older than 80 years? ### Response:
This is the first study to demonstrate a difference in 1-year mortality between patients who were community ambulators versus those who were household ambulators or nonfunctional ambulators before injury. With our aging population, these findings have important implications. Maintenance of general conditioning and early mobilization with physical therapy after injury is a key part of geriatric orthopedic rehabilitation.
### Instruction: Is tumor necrosis factor inhibitor therapy but not standard therapy associated with resolution of erosion in the sacroiliac joints of patients with axial spondyloarthritis? ### Response:
The SPARCC SSS method for assessment of structural lesions has discriminative capacity in demonstrating significantly greater reduction in erosion and new fat metaplasia in patients receiving anti-TNFα therapy.
### Instruction: Is serum cytokeratin-19 fragment ( Cyfra 21-1 ) a prognostic indicator for epithelial ovarian cancer? ### Response:
The pretreatment level of serum Cyfra 21-1 had remarkable prognostic significance for EOC, indicating poor survival when it was elevated above 3.0 ng/mL.
### Instruction: Is serum acid sphingomyelinase upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease? ### Response:
Chronic hepatitis C virus infection and non-alcoholic fatty liver disease induce a significant upregulation of serum acid sphingomyelinase which appears as a novel biomarker in chronic hepatopathies. Further studies are required to elucidate the potential of the sphingolipid signaling pathway as putative therapeutic target in chronic liver disease.
### Instruction: Do eye movements reveal impaired inhibitory control in adult male fragile X premutation carriers asymptomatic for FXTAS? ### Response:
Antisaccades require inhibitory control to inhibit reflexive eye movements. We found that eye movements are sensitive to impaired inhibitory control in fXPCs asymptomatic for FXTAS. Thus, eye movements may be useful in assessing FXTAS risk or disease progression.
### Instruction: Does carpal tunnel syndrome impair thumb opposition and circumduction motion? ### Response:
Carpal tunnel syndrome disrupts kinematics of the thumb during opposition and circumduction despite normal pinch strength.
### Instruction: Does genome-wide study of hypomethylated and induced genes in patients with liver cancer unravel novel anticancer targets? ### Response:
Our results prove that genes that are hypomethylated and induced in tumors are candidate targets for anticancer therapeutics in multiple cancer cell types. Because these genes are particularly activated in cancer, they constitute a group of targets for specific pharmacologic inhibitors of cancer and cancer metastasis. Clin Cancer Res; 20(12); 3118-32. ©2014 AACR.
### Instruction: Does low-intensity pulsed ultrasound induce osteogenic differentiation of human periodontal ligament cells through activation of bone morphogenetic protein-smad signaling? ### Response:
Low-intensity pulsed US effectively induced osteogenic differentiation of human periodontal ligament cells, and the BMP-Smad signaling pathway was involved in the mechanism.
### Instruction: Does paley 's multiplier method accurately predict adult height in children with bone sarcoma? ### Response:
Owing to its lack of reliability in this patient group, methods other than Paley's should be evaluated to predict adult height. Although limited by a small number of patients, our study results indicate a decreased adult height in patients with bone sarcoma after chemotherapy.
### Instruction: Does fasting protect liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice? ### Response:
Fasting for one day protects from hepatic IR injury via Sirt1-dependent downregulation of circulating HMGB1. The reduction in serum HMGB1 appears to be mediated by its engagement in the autophagic response. These findings integrate Sirt1, HMGB1, and autophagy into a common framework that underlies the anti-inflammatory properties of short-term fasting.
### Instruction: Does pPAR-alpha dependent regulation of vanin-1 mediate hepatic lipid metabolism? ### Response:
We show that hepatic vanin-1 is under extremely sensitive regulation by PPARα and that plasma vanin activity could serve as a readout of changes in PPARα activity in human subjects. In addition, our data propose a role for vanin-1 in regulation of hepatic TG levels during fasting.
### Instruction: Does coffee consumption and the risk of latent autoimmune diabetes in adults -- result from a Swedish case-control study? ### Response:
Our findings confirm that coffee consumption is associated with a reduced risk of Type 2 diabetes. Interestingly, the findings suggest that coffee may be associated with development of autoimmunity and possibly an increased risk of more Type 1-like latent autoimmune diabetes in adults.
### Instruction: Does downregulation of the glucocorticoid-induced leucine zipper ( GILZ ) promote vascular inflammation? ### Response:
Our data show a diminished expression of the anti-inflammatory mediator GILZ in the inflamed vasculature and indicate that GILZ downregulation requires the mRNA binding protein ZFP36. We suggest that reduced GILZ levels play a role in cardiovascular disease.
### Instruction: Is playground Safety Associated With Playground , Park , and Neighborhood Characteristics? ### Response:
Park safety levels need to be improved to reduce the risk of physical injuries. Future studies examining cause-effect associations between environmental features and playground safety are warranted.
### Instruction: Is aortic valve calcification mediated by a differential response of aortic valve interstitial cells to inflammation? ### Response:
Proinflammatory stimulation induces an osteogenic phenotype in aortic VICs but not mitral, pulmonic, or tricuspid VICs. We conclude that this differential osteogenic response of aortic VICs contributes to the pathogenesis of calcific aortic stenosis.
### Instruction: Is inflammation the cause of an elevated serum ferritin in non-alcoholic fatty liver disease? ### Response:
Serum ferritin is related to liver iron storage in NAFLD and decreasing body iron stores by phlebotomy is reflected by an appropriate decrease in serum ferritin. Inflammation is not the cause of the elevated serum ferritin in fatty liver disease.
### Instruction: Does pain self-efficacy mediate the relationship between depressive symptoms and pain severity? ### Response:
These findings suggest that pain management and rehabilitation programs for CLBP should specifically target PSE as a key aspect of treatment.
### Instruction: Is polymorphism in the epidermal growth factor gene associated with pre-eclampsia and low birthweight? ### Response:
In this study we found further evidence for the association of polymorphism in the EGF gene with pre-eclampsia and the weight of babies at birth and identified rs3756261A>G as the SNP that makes the most significant contribution to this association. Bioinformatic analysis showed that this effect may be mediated by caudal type homeohox-2, a transcriptional repressor expressed in the trophoblast, for which a binding site is created at this polymorphic site when the rs3756261A allele is present.
### Instruction: Do insulin resistant rats display enhanced rewarding effects of nicotine? ### Response:
These present study suggests that insulin resistant rats undergo unique neurobiological changes related to a disruption in insulin signaling that promotes the rewarding effects of nicotine.
### Instruction: Is immature reticulocyte fraction an early predictor of bone marrow recovery post chemotherapy in patients with acute leukemia? ### Response:
This study proved that IRF was more useful in predicting bone marrow recovery in a patient with acute leukemia post induction chemotherapy compared with ANC. The IRF is not affected by infection, is easily measured, and inexpensive; thus, it is a reliable parameter to evaluate bone marrow reconstitution.
### Instruction: Are nadir PSA level and time to nadir PSA prognostic factors in patients with metastatic prostate cancer? ### Response:
Nadir PSA and time from PADT to nadir were factors that affect both CRPC and overall survival in a cohort of patients with metastatic prostate cancer. Lower nadir PSA level and longer time from PADT to nadir were good for survival and progression.
### Instruction: Do skin stretching for primary closure of acute burn wounds? ### Response:
Skin Stretch for primary closure of acute burn wounds is a suitable technique and can be considered for specific circumscript full-thickness burn wounds. However, future research should be performed to provide additional scientific evidence.
### Instruction: Is canonical androstenedione reduction the predominant source of signaling androgens in hormone-refractory prostate cancer? ### Response:
Reduction of androstenedione to testosterone by the canonical HSD17B AKR1C3 is the predominant source of signaling androgens in HRPC.
### Instruction: Is hsa-miR-31-3p expression linked to progression-free survival in patients with KRAS wild-type metastatic colorectal cancer treated with anti-EGFR therapy? ### Response:
Hsa-miR-31-3p seems to be a new mCRC biomarker whose expression level allows for the identification of patients with wild-type KRAS mCRC who are more likely to respond to anti-EGFR therapy.
### Instruction: Does rNAi screen identify a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition? ### Response:
Our findings demonstrate that PIM1-overexpressing cancer cells are particularly sensitive to PLK1 inhibition, suggesting that PIM1 might be used as a marker for identifying patients who will benefit from PLK1 inhibitor treatment.
### Instruction: Do ramp-incremented and RPE-clamped test protocols elicit similar VO2max values in trained cyclists? ### Response:
The RPE-clamped test protocol was as effective as the ramp-incremented protocol for eliciting VO2max and could be considered as a valid alternative protocol, particularly where a fixed test duration is desirable.
### Instruction: Does caregiver Quality of Life be Related to Severity of Otitis Media in Children? ### Response:
Worse PedsQL Family Impact and PROMIS scores were highly correlated with elevated OM-6 scores, suggesting that severity of childhood OM significantly affects parent/caregiver QoL. Understanding the impact of a child's illness on parent/caregiver QoL can help physicians counsel patients and families and provide better family-centered, compassionate care.
### Instruction: Are perioperative complications after hemiarthroplasty and total shoulder arthroplasty equivalent? ### Response:
Multivariate analysis of patients undergoing TSA or HA in the NSQIP database suggests that patient factors-not the procedure being performed-are significant predictors of major complications. Controlling for patient comorbidities, we found no increased risk of perioperative major complications in patients undergoing TSA compared with HA.
### Instruction: Are action potentials in retinal ganglion cells initiated at the site of maximal curvature of the extracellular potential? ### Response:
We present a framework how to estimate the site of action potential initiation and the stimulus required to cross threshold in neurons tightly interfaced to capacitive stimulation electrodes. Our results underscore the necessity of rigorous electrical characterization of the stimulation electrodes and of the interfaced neural tissue.
### Instruction: Are vitamin D deficiency in community-acquired pneumonia : low levels of 1,25 ( OH ) 2 D associated with disease severity? ### Response:
For 1,25-OH2, we found a significant and independent (controlled for age, season and pathogen) negative correlation to pneumonia severity. Therefore, supplementation of non-activated vitamin D to protect from pneumonia may be non-sufficient in patients that have a decreased capacity to hydroxylate 25-OH to 1,25-OH2.
### Instruction: Are most domains of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 reliable? ### Response:
Most domains on the EORTC QLQ-C30 are reliable and may therefore be used to help inform decision-making processes, such as those involving individual patients.
### Instruction: Does spanish adaptation of the internal functioning of the Work team Scale ( QFI-22 )? ### Response:
The QFI-22 scale is a useful instrument for assessing the internal functioning of work teams.
### Instruction: Is image more than a uniform : the promise of assurance? ### Response:
Overall appearance and behaviors define the image of nurses and contribute significantly to the brand of assurance.
### Instruction: Do physiologic doses of depot-medroxyprogesterone acetate increase acute plasma simian HIV viremia or mucosal virus shedding in pigtail macaques? ### Response:
In this pigtail macaque model of DMPA and vaginal SHIV infection, we found little or no effect of DMPA on plasma viremia and mucosal virus shedding during acute infection. These results do not support a role of DMPA in increasing mucosal HIV shedding.
### Instruction: Are haemorrhoids associated with internal iliac vein reflux in up to one-third of women presenting with varicose veins associated with pelvic vein reflux? ### Response:
There is a strong association between haemorrhoids and internal Iliac vein reflux. Untreated reflux may be a cause of subsequent symptomatic haemorrhoids. Treatment with methods proven to work in conditions caused by pelvic vein incompetence, such as pelvic vein embolisation and foam sclerotherapy, could be considered.
### Instruction: Does [ REGgamma promote malignant behaviors of lung cancer cells ]? ### Response:
REGgamma facilitates malignant biological behaviors of lung cancers.
### Instruction: Does the mu opioid receptor activation affect ischemia-induced agonal currents in rat spinal ventral horn? ### Response:
Activation of MORs does not influence ongoing ischemia-induced neuronal death. Our findings indicate that MOR agonist administration should be suitable as an anesthetic during aortic surgery.
### Instruction: Does improving search over Electronic Health Records using UMLS-based query expansion through random walk? ### Response:
Our analysis shows that the success of our method is due to the automatic expansion of the query with extra terms, even when they are not directly related in the UMLS Metathesaurus. The terms added in the expansion go beyond simple synonyms, and also add other kinds of topically related terms.
### Instruction: Does hospital Case Volume be Associated With Improved Survival for Patients With Metastatic Melanoma? ### Response:
For patients diagnosed with metastatic melanoma, being treated in a high-volume hospital was associated with an improvement in survival and lower utilization of chemotherapy, immunotherapy, surgery, and radiation therapy.
### Instruction: Is n-acetyl-l-methionine a superior protectant of human serum albumin against photo-oxidation and reactive oxygen species compared to N-acetyl-L-tryptophan? ### Response:
The weakly bound N-AcMet is a superior protectant of albumin, because it is a better ROS-protector and structural stabilizer than N-AcTrp, and it is probable and also useful for other protein preparations.
### Instruction: Is arecoline cytotoxic for human endothelial cells? ### Response:
Arecoline is cytotoxic via necrosis for endothelium, while biochemical assays indicate no appreciable cellular leakage before death and detachment, as well as no clear effect on mitochondrial function in viable cells. Arecoline toxicity may thus contribute to reduced vascularity in oral submucous fibrosis.
### Instruction: Do parents as moderators of longitudinal associations between sexual peer norms and Dutch adolescents ' sexual initiation and intention? ### Response:
Our findings show that different types of sexual peer norms and both general and sexuality-specific parenting play an important role in the early stages of Dutch adolescents' sexual trajectories. Moreover, parent-adolescent communication about sexuality can function as a buffer for the sex-stimulating effects of sexual peer norms.
### Instruction: Does bisphenol A increase atherosclerosis in pregnane X receptor-humanized ApoE deficient mice? ### Response:
These findings identify a molecular mechanism that could link BPA exposure to increased risk of CVD in exposed individuals. PXR is therefore a relevant target for future risk assessment of BPA and related environmental chemicals in humans.
### Instruction: Does lithium increase nitric oxide levels in subjects with bipolar disorder during depressive episodes? ### Response:
The present findings suggest that lithium upregulates NO signaling in unmedicated BD with short illness duration. Further studies with larger samples are needed to confirm the effects of lithium on NO pathway and its association with synaptic plasticity and therapeutics of BD.
### Instruction: Does olmesartan prevent cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and p53? ### Response:
Olm prevents cardiac rupture through inhibition of apoptosis and inflammation, which is attributable to the down-regulation of p53 activity and up-regulation of GDF-15. Our findings suggest that early administration of an AT1 receptor anatagonist to patients with acute MI is a potential preventive approach for cardiac rupture.
### Instruction: Is surgical strategy for the gastric gastrointestinal stromal tumors ( GISTs ) larger than 5 cm : laparoscopic surgery feasible , safe , and oncologically acceptable? ### Response:
In patients with gastric GISTs >5 cm, LAP can be performed with outcomes equivalent to those of OPEN if patient selection and intraoperative judgment are appropriate.
### Instruction: Is γ-Glutamyltranspeptidase a prognostic marker of survival and recurrence in radiofrequency-ablation treatment of hepatocellular carcinoma? ### Response:
Serum GGT is a convenient prognostic biomarker related to OS and recurrence in HCC patients undergoing RFA treatment.
### Instruction: Do soft-tissue response rate to chin skeletal advancement in patients with lower facial burn scar? ### Response:
Burn-related retrusive chin can appropriately be treated with sliding osseous genioplasty and will require slight overcorrection compared with patients without a history of lower face burn.
### Instruction: Does inhibition of proteasome-mediated glucocorticoid receptor degradation restore nitric oxide bioavailability in myocardial endothelial cells in vitro? ### Response:
Summarising our results, we propose a new mechanism involved in the regulation of NO signalling by GCs in myocardial endothelial cells. We suggest that a sufficient GR protein expression plays a crucial role for the management of GC-induced harmful adverse effects, including deregulations of vasorelaxation arising from disturbed NO biosynthesis.
### Instruction: Is randomization associated with socio-economic and demographic factors in a multi-center clinical trial of children with sickle cell anemia? ### Response:
In the SIT Trial, acceptance of random allocation was not associated with socio-economic or demographic factors. Although these factors may represent barriers for some participants, they should not bias investigators caring for children with SCD in their approach to recruitment for clinical trial participation.
### Instruction: Does technical challenge encountered during deployment of the ovation abdominal aortic stent-graft system? ### Response:
Awareness of certain aspects associated with the use of the Ovation device and adoption of the adjunctive techniques herein described helps the interventionist avoid unexpected challenges or manage technical difficulties to maximize the device's safety and effectiveness.
### Instruction: Does recovery from neuromuscular block in dogs : restoration of spontaneous ventilation exclude residual blockade? ### Response:
Significant residual neuromuscular block could be measured at the hind limb with acceleromyography when ventilation had spontaneously returned to pre-vecuronium values. Monitoring spontaneous ventilation, including end-tidal CO2 , expired tidal volume, peak inspiratory flow or minute ventilation cannot be used as a surrogate for objective neuromuscular monitoring, and this practice may increase the risk of postoperative residual paralysis.
### Instruction: Does co-ingestion of caffeine and carbohydrate after meal improve performance at high-intensity intermittent sprints with short recovery times? ### Response:
Co-ingestion of CAF and CHO did not improve high-intensity sprint cycling performance or reduce fatigue in active males. Moreover, combined CAF and CHO supplementation might facilitate catabolism during prolonged high-intensity intermittent exercise.
### Instruction: Does combining heat stress and moderate hypoxia reduce cycling time to exhaustion without modifying neuromuscular fatigue characteristics? ### Response:
Moderate hypoxia in combination with heat stress reduces cycling time to exhaustion without modifying neuromuscular fatigue characteristics. Impaired oxygen delivery or increased cardiovascular strain, increasing relative exercise intensity, may have also contributed to earlier exercise cessation.
### Instruction: Do extended high-frequency ( 9-20 kHz ) audiometry reference thresholds in 645 healthy subjects? ### Response:
When comparing different studies the hearing thresholds were found to be similar. Therefore, it would be possible to establish international standard thresholds.
### Instruction: Does inhibition of peripheral FAAH depress activities of bladder mechanosensitive nerve fibers of the rat? ### Response:
To our knowledge we report for the first time that inhibiting peripheral FAAH depresses the Aδ and C-fiber activity of primary bladder afferents via CB1 and CB2 receptors. CB antagonists alone exerted facilitatory effects on single unit afferent activity during bladder filling in rats. The endocannabinoid system may be involved in physiological control of micturition as regulators of afferent signals.
### Instruction: Are soluble Klotho levels in adult renal transplant recipients modulated by recombinant human erythropoietin? ### Response:
Our results demonstrate that KTR have higher serum Klotho levels than HS and that rhEPO treatment modulates these concentrations, suggesting a link between rhEPO and soluble Klotho in KTR.
### Instruction: Does dual tasking during postural stepping responses increase falls but not freezing in people with Parkinson 's disease? ### Response:
For people with PD and FoG, forward falls may not always be caused by FoG, particularly under attention-distracting conditions.
### Instruction: Does physical exercise antagonize clinical and anatomical features characterizing Lieber-DeCarli diet-induced obesity and related metabolic disorders? ### Response:
ET used as a therapeutic tool mitigated the clinical/anatomical-related features induced by Liber-DeCarli diet, thus possibly contributing to control obesity and metabolic disorders.
### Instruction: Do public-private partnerships improve health outcomes in individuals with early stage Alzheimer 's disease? ### Response:
PLM was successful in improving detection of incident cases of dementia in the community and in connecting patients and their families with needed services. Our findings support the use of state agencies and community service partners to detect dementia. Early implementation of psychosocial interventions could have significant impact in improving patient- and family-centered outcomes, potentially providing a cost-efficient alternative to pharmacotherapy.
### Instruction: Does local injection of vasopressin reduce the blood loss during cesarean section in placenta previa? ### Response:
The local injection of vasopressin into the placental implantation site significantly reduced the blood loss without increasing the morbidity.
### Instruction: Does topical application of Kochia scoparia inhibit the development of contact dermatitis in mice? ### Response:
These findings indicated that KSW ameliorates contact dermatitis via inhibition of the production of several inflammatory mediators. Therefore, external application of KSW may be used for the treatment of contact dermatitis as an alternative therapy.
### Instruction: Does preconditioning with the traditional Chinese medicine Huang-Lian-Jie-Du-Tang initiate HIF-1α-dependent neuroprotection against cerebral ischemia in rats? ### Response:
Both rats and neurons subjected to HLJDT preconditioning were able to resist ischemia/reperfusion or hypoxia injury through the inhibition of apoptosis and the enhancement of proliferation, and these effects were primarily dependent on the activation of the PI3K/Akt signaling pathway and HIF-1α.
### Instruction: Does information-enhancement and goal setting techniques for increasing adaptive motivation and decreasing urge to drink alcohol? ### Response:
The results show that sense of control can be experimentally induced. This finding has important clinical implications.