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### Instruction: Does raf Kinase Inhibitory Protein protect cells against locostatin-mediated inhibition of migration? ### Response:
These results suggest that locostatin's effects on cytoskeletal structure and migration are caused through mechanisms independent of its binding to RKIP and Raf/MAP kinase signaling. The protective effect of RKIP against drug inhibition of migration suggests a new role for RKIP in potentially sequestering toxic compounds that may have deleterious effects on cells.
### Instruction: Are reactive oxidative metabolites associated with atrial conduction disturbance in patients with atrial fibrillation? ### Response:
Serum markers of oxidative stress reflect atrial conduction disturbance and predict AF recurrence after RF catheter ablation in paroxysmal AF patients. DROM could serve as a biomarker for predicting risk of AF recurrence after RF catheter ablation.
### Instruction: Is lymphocyte transformation test helpful for the diagnosis of methotrexate-induced pneumonitis in patients with rheumatoid arthritis? ### Response:
LTT with MTX in RA patients is not appropriate to detect MTX-induced pneumonitis.
### Instruction: Is quantitative UPLC-MS/MS analysis of underivatised amino acids in body fluids a reliable tool for the diagnosis and follow-up of patients with inborn errors of metabolism? ### Response:
UPLC-MS/MS analysis of amino acids in body fluids is rapid, reliable and suitable for the diagnosis and follow-up patients with IEM.
### Instruction: Does [ Edaravone protect hearing from acute acoustic trauma in guinea pigs ]? ### Response:
The level of ROS in cochlea were decreased significantly after intratympanic edaravone injection. The mechanism may due to its effective clearance of the ROS in cochlea.
### Instruction: Does increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicate autonomous cortisol production in adrenocortical tumors? ### Response:
The ratio between the expression of the genes CYP17 and CYP11B1 in tumors from patients with Cushing's syndrome is significantly higher than in the non-hyperfunctioning tumors. This indicates that 17alpha-hydroxylase is a major determinant of cortisol overproduction. The patients with subclinical Cushing's syndrome in this study are too few to draw any firm conclusions although the results suggest that subclinical Cushing's syndrome may be identified post-operatively with this method.
### Instruction: Does ganoderma lucidum induce the expression of CD40/CD86 on peripheral blood monocytes? ### Response:
G. lucidum enhanced the expression of CD40 and CD80 molecules on peripheral blood monocytic cells derived from both sexes in a dose-dependent manner, with a preferential higher effect on cells obtained from female donors.
### Instruction: Does usability testing found problems for novice users of pediatric portals? ### Response:
Despite parental involvement and prior heuristic testing, scenario-based testing demonstrated difficulties in navigation, medical language complexity, error recovery, and provider-based organizational schema. While such usability testing can be expensive, the current study demonstrates that it can assist in making healthcare system interfaces for laypersons more user-friendly and potentially more functional for patients and their families.
### Instruction: Are nocturnal enuresis and overweight associated with obstructive sleep apnea? ### Response:
Overweight and MNE are associated with OSA but not with each other. OSA should be considered in overweight children with MNE, especially when they display other symptoms of OSA or fail to respond to standard MNE treatment programs.
### Instruction: Does nonresponse to pre-operative chemotherapy preclude long-term survival after liver resection in patients with colorectal liver metastases? ### Response:
Liver resection offers a long-term survival benefit for patients with CRM, even when tumor growth proceeds during pre-operative chemotherapy.
### Instruction: Does palliative sedation therapy hasten death : results from a prospective multicenter study? ### Response:
PST does not shorten life when used to relieve refractory symptoms and does not need the doctrine of double effect to justify its use from an ethical point of view.
### Instruction: Do hLA-DQB1 subtypes predict diabetic retinopathy in patients with type I diabetes mellitus? ### Response:
Some haplotypes seem to predispose diabetic patients to diabetic retinopathy. HLA typing may be beneficial for predicting the prognosis of diabetic retinopathy in younger diabetic patients.
### Instruction: Is sleep apnea an independent correlate of erectile and sexual dysfunction? ### Response:
ED and overall sexual dysfunction were highly prevalent in patients with suspected OSA. Irrespective of known risk factors, mean nocturnal SaO(2) was an additional, independent correlate of these dysfunctions, suggesting that OSA-related intermittent nocturnal hypoxemia specifically contributes to their development.
### Instruction: Do retinal vascular occlusions occur more frequently in the more affected eye in exfoliation syndrome? ### Response:
Retinal vascular occlusion in patients with XFS occurs most often in the affected or more severely affected eye. As vascular occlusions happened in patients with and without glaucoma in similar proportions, the presence of XFS seems to play an important role in these findings.
### Instruction: Does maternal allopurinol during fetal hypoxia lower cord blood levels of the brain injury marker S-100B? ### Response:
Maternal allopurinol/oxypurinol crosses the placenta during fetal hypoxia. In fetuses/newborns with therapeutic allopurinol/oxypurinol concentrations in cord blood, lower plasma levels of the brain injury marker protein S-100B were detected. A larger allopurinol trial in compromised fetuses at term seems warranted. The allopurinol dosage must be adjusted to achieve therapeutic fetal allopurinol/oxypurinol concentrations.
### Instruction: Is elevated cerebral pressure passivity associated with prematurity-related intracranial hemorrhage? ### Response:
This novel cerebrovascular monitoring technique allows quantification of cerebral pressure passivity as MAP-HbD gain in premature infants. High MAP-HbD gain is significantly associated with GM/IVH. Precise temporal and causal relationship between MAP-HbD gain and GM/IVH awaits further study.
### Instruction: Is carbon monoxide a significant mediator of cardiovascular status following preterm birth? ### Response:
The gestational age- and gender-specific differences in carboxyhemoglobin levels and the relationship with dysregulated microvascular blood flow, a state related to greater illness severity and hypotension, are novel findings not confined solely to sick preterm infants. Both inducible heme oxygenase-dependent and non-heme oxygenase-dependent pathways may initially play a central role in carbon monoxide production, inducing pathophysiologic processes in a gender-specific manner.
### Instruction: Are serum gentamicin concentrations in encephalopathic infants affected by therapeutic hypothermia? ### Response:
Our data confirm that impaired renal function is strongly associated with high SGCs. Reduced body temperatures do not affect the clearance of gentamicin.
### Instruction: Are plasma fibrinogen and D-dimer concentrations associated with the presence of abdominal aortic aneurysm : a systematic review and meta-analysis? ### Response:
We found that plasma fibrinogen and D-dimer concentrations are likely to be higher in cases with AAA than control subjects. Higher plasma fibrinogen and D-dimer concentrations may be associated with the presence of AAA.
### Instruction: Do drosera rotundifolia and Drosera tokaiensis suppress the activation of HMC-1 human mast cells? ### Response:
Drosera rotundifolia and Drosera tokaiensis suppressed activation of HMC-1 cells induced by aTc-m. Since the Drosera tokaiensis fraction was more effective than the traditionally used Drosera rotundifolia, Drosera tokaiensis is a likely substitute as a source of Droserae Herba.
### Instruction: Do multiple monophasic shocks improve electrotherapy of ventricular tachycardia in a rabbit model of chronic infarction? ### Response:
Maintenance of shock-induced virtual electrode polarization by multiple monophasic shocks over a VT cycle is responsible for unpinning of reentry leading to self-termination. Elimination of virtual electrode polarization by shock polarity reversal during multiple biphasic shocks proved ineffective. A significant reduction in CVT can be achieved by applying multiple monophasic shocks within one VT CL or one single shock at the proper coupling interval.
### Instruction: Is there no transmural heterogeneity in an index of action potential duration in the canine left ventricle? ### Response:
In the intact canine left ventricular wall, a more or less homogeneous distribution in transmural ERP and ARI is present.
### Instruction: Is full-length cytokeratin-19 released by human tumor cells : a potential role in metastatic progression of breast cancer? ### Response:
Full-length CK19 is released by viable epithelial tumor cells, and CK19-RCs might constitute a biologically active subset of breast cancer cells with high metastatic properties.
### Instruction: Does dietary carbohydrate modification alter serum metabolic profiles in individuals with the metabolic syndrome? ### Response:
Our results suggest that the dietary carbohydrate modification alters the serum metabolic profile, especially in lysoPC species, and may, thus, contribute to proinflammatory processes which in turn promote adverse changes in insulin and glucose metabolism.
### Instruction: Does marine-derived oligosaccharide sulfate ( JG3 ) suppress heparanase-driven cell adhesion events in heparanase over-expressing CHO-K1 cells? ### Response:
All these findings help form an alternative view to understand the mechanisms underlying the inhibitory effects of JG3 on cell motility.Acta Pharmacologica Sinica (2009) 30: 1033-1038; doi: 10.1038/aps.2009.97; published online 22 June 2009.
### Instruction: Do anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways? ### Response:
Our findings indicate that anti-CCP antibodies activate the complement system in vitro via the classical and alternative pathways but not via the lectin pathway. These findings are relevant for the design of interventions aimed at inhibition of complement-mediated damage in RA.
### Instruction: Does transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuate K/BxN mouse serum-induced arthritis in vivo? ### Response:
Disruption of GC signaling in osteoblasts significantly attenuates K/BxN mouse serum-induced autoimmune arthritis in mice. These data suggest that osteoblasts modulate the immune-mediated inflammatory response via a GC-dependent pathway.
### Instruction: Are variants in TNFAIP3 , STAT4 , and C12orf30 loci associated with multiple autoimmune diseases also associated with juvenile idiopathic arthritis? ### Response:
We have demonstrated associations between JIA and variants in the TNFAIP3, STAT4, and C12orf30 regions that have previously shown associations with other autoimmune diseases, including RA and systemic lupus erythematosus. Our results suggest that clinically distinct autoimmune phenotypes share common genetic susceptibility factors.
### Instruction: Does hydration status influence peritoneal equilibration test ultrafiltration volumes? ### Response:
It was found that PET test ultrafiltration volume in routine clinical practice was not affected by CRP, hyperglycemia, or extracellular fluid volume overload. Ultrafiltration volumes were increased in those patients with reduced serum sodium and albumin, most likely because of inflammation and protein malnutrition.
### Instruction: Does fACS-assisted microarray profiling implicate novel genes and pathways in zebrafish gastrointestinal tract development? ### Response:
We successfully combine FACS and microarray profiling to follow organogenesis throughout development. These experiments identify novel genes and pathways that probably play a role in mammalian gastrointestinal development and are potential targets for therapeutic intervention in the management of gastrointestinal disease and cancer.
### Instruction: Are s-phase cells more sensitive to high-linear energy transfer radiation? ### Response:
S-phase cells are more sensitive to high-LET IR than nonsynchronized and G(2)-phase cells, because of the following mechanism: it is more difficult for Ku protein to bind to high-LET IR-induced DNA DSBs in S-phase cells than in cells at other phases, which results in less efficient NHEJ.
### Instruction: Does botulinum toxin B increase mouth opening in patients with spastic trismus? ### Response:
Botulinum toxin serotype B injections into the masseter muscles effectively reduce hypertonia and provide for better mouth opening, thereby contributing to a positive and desired clinical goal.
### Instruction: Does a common UCP2 polymorphism predispose to stress hyperglycaemia in severe sepsis? ### Response:
A common, functional polymorphism in the promoter region of the UCP2 gene is associated with hyperglycaemia and insulin resistance in severe sepsis. This has implications for our understanding of the genetic pathophysiology of sepsis and is of use in the stratification of patients for more intensive management.
### Instruction: Does fK778 attenuate cytomegalovirus-enhanced vein graft intimal hyperplasia in a rat model? ### Response:
These data suggest a role of CMV in venous graft failure. Also, our results suggest a prospective role for the new immunosuppressive drug FK778 in the prevention of (CMV-mediated) vein graft intimal hyperplasia.
### Instruction: Does use of the trendelenburg position in the porcine model improve carotid flow during cardiopulmonary resuscitation? ### Response:
The Trendelenburg position can lead to increased blood flow through the carotid arteries during CPR in this pig model. Future studies should investigate whether this increased blood flow through the carotid arteries leads to improved brain perfusion and better neurologic outcomes.
### Instruction: Do neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish? ### Response:
Our analyses of nsf mutant zebrafish reveal an unexpected role for NSF in hypothalamic development, with mutant 5 days post-fertilization larvae exhibiting a stage-dependent loss of neuroendocrine transcripts and a corresponding accumulation of neuropeptides in the soma. Based on our collective findings, we speculate that neuroendocrine transcriptional programs adapt dynamically to both the supply and demand for neuropeptides to ensure adequate homeostatic responses.
### Instruction: Does molecular analysis of persistent periradicular lesions and root end reveals a diverse microbial profile? ### Response:
Persistent periradicular lesions are polymicrobial infections with many as-yet-uncultivated and unknown bacterial species. The bacterial load and microbial profile of root ends is significantly different from the soft-tissue lesion, indicating the presence of diverse bacterial populations in these tissues.
### Instruction: Does smoking attenuate the negative association between carotenoids consumption and colorectal cancer risk? ### Response:
Consumption of most dietary carotenoids was found to be strongly associated with reduced risk of CRC. However, smoking significantly attenuated or reversed this observed protective effect on CRC occurrence. Smokers should be advised that smoking also hampers the potential health promoting effects of high fruit and vegetable consumption.
### Instruction: Is interleukin-6 a significant predictor of radiographic knee osteoarthritis : The Chingford Study? ### Response:
This followup study showed that individuals were more likely to be diagnosed as having RKOA if they had a higher BMI and increased circulating levels of IL-6. These results should stimulate more work on IL-6 as a potential therapeutic target.
### Instruction: Does mouse strain determine the outcome of wound healing after myocardial infarction? ### Response:
The outcome of infarct healing in mice strongly depends on genetic background. On the basis of our results, we suggest that for studies on infarct rupture, the 129S6 mouse is the background of choice, whereas BalbC and Swiss mice are the preferred models to study infarct thinning post-MI.
### Instruction: Are tumor necrosis factor region polymorphisms associated with AIDS and with cytomegalovirus retinitis? ### Response:
This study highlights that polymorphic sites spanning the region nearby the TNF locus are associated with AIDS per se and with cytomegalovirus retinitis in AIDS patients.
### Instruction: Is walking speed at self-selected exercise pace lower but energy cost higher in older versus younger women? ### Response:
Preferred exercise pace incurs a higher metabolic cost in older women and needs be taken into consideration when recommending walking as an exercise modality.
### Instruction: Does the dihydropyridine calcium channel blocker benidipine prevent lysophosphatidylcholine-induced endothelial dysfunction in rat aorta? ### Response:
These results suggest that benidipine inhibited LPC-induced endothelial dysfunction by maintaining increase in [Ca2+]i. Benidipine possesses membrane stabilization properties in LPC-treated endothelial cells. It is speculated that the preservation of membrane fluidity by benidipine may play a role in the retainment of calcium mobilization. The present findings may provide new insights into the endothelial protective effects of benidipine.
### Instruction: Is n-3 polyunsaturated fatty acids in milk associate to weight gain and growth in premature infants? ### Response:
These results suggest that the n-3 PUFA composition of milk may be associated with weight gain and growth. Considering the advantages of n-3 LC-PUFA consumption on infant growth and visual function and its association with reduced incidence of premature birth, dietitians should advise pregnant women to increase their intake of foods high in n-3 LC-PUFA.
### Instruction: Are drug transporters altered in brain , liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine? ### Response:
Organic anion transporting polypeptide 2 and P-gp colocalized in tissues that are important in drug absorption, metabolism and excretion. Seizures seem to induce the cerebral changes of P-gp and Oatp2. However, the changes of expression of two transporters exhibit the opposite trend. Organic anion transporting polypeptide 2 might play a different role than P-gp in intractable epilepsy. Our data provide a basis for the assessment of the role of uptake transporters and efflux pumps in the development of intractable epilepsy.
### Instruction: Are an early increase in gamma glutamyltranspeptidase and low aspartate aminotransferase peak values associated with superior outcomes after orthotopic liver transplantation? ### Response:
Unexpectedly, a disproportionate rise in gamma-GT was associated with graft and patient survival of more than 90 days. This might be explained by regeneration phenomena in the liver indicative of a well functioning graft.
### Instruction: Does the Impact of type 2 diabetes on mortality in end-stage renal disease patients differ between genders? ### Response:
T2DM was associated with death only in females. This association was not constant over time after the first dialysis.
### Instruction: Do manual and electronic probes have similar reliability in the measurement of untreated periodontitis? ### Response:
Manual and electronic probes were of similar reliability when used to measure CAL in individuals who had untreated periodontitis and when used by a calibrated examiner, but this finding is not supported by strong evidence.
### Instruction: Is abnormal uterine artery Doppler in pregnancies suspected of a SGA fetus related to increased risk of recurrence during next pregnancy? ### Response:
The results suggest that abnormal uterine artery Doppler is related to increased risk of recurrence of SGA during the next pregnancy. This knowledge might provide the clinician with an opportunity to initiate preventive treatment and increase surveillance to women at risk during succeeding pregnancy.
### Instruction: Does nebivolol induce parallel improvement of left ventricular filling pressure and coronary flow reserve in uncomplicated arterial hypertension? ### Response:
Nebivolol improves LVFP as well as CFR in uncomplicated hypertension. The association between changes of CFR and those of LVFP indicates a possible common denominator between improvement of coronary microvascular function and myocardial stimulation of nitric oxide release induced by the drug.
### Instruction: Are hFE C282Y/H63D compound heterozygotes at low risk of hemochromatosis-related morbidity? ### Response:
For male compound heterozygotes, mean iron indices do not change during middle age but for female compound heterozygotes menopause results in increased mean SF. Although compound heterozygotes might maintain elevated iron indices during middle age, documented iron overload-related disease is rare.
### Instruction: Does diabetes mellitus activate signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes? ### Response:
We propose that elevated advanced glycation end products expression and increased oxidative stress in diabetic monocytes lead to activation of VEGFR-1-related signaling pathways and to desensitization of VEGFR-1 responses. These data establish VEGF resistance as a novel molecular concept for DM-related cellular dysfunction.
### Instruction: Do elevated depression symptoms predict long-term cardiovascular mortality in patients with atrial fibrillation and heart failure? ### Response:
Elevated depression symptoms are related to cardiovascular mortality even after adjustment for other prognostic indicators in patients with comorbid AF and CHF who receive optimized treatment. Unmarried patients are also at increased risk. Mechanisms and treatment options deserve additional study.
### Instruction: Does post-resuscitation NOS inhibition improve hemodynamic recovery of hypoxic newborn pigs? ### Response:
Post-resuscitation administration of NAC improved cardiac function and reduced oxidative stress in newborn pigs with hypoxia-reoxygenation insult. Low-dose, non-selective inhibitor of nitric oxide synthase activity did not provide any further beneficial effect.
### Instruction: Are new users of metformin at low risk of incident cancer : a cohort study among people with type 2 diabetes? ### Response:
These results suggest that metformin use may be associated with a reduced risk of cancer. A randomized trial is needed to assess whether metformin is protective in a population at high risk for cancer.
### Instruction: Are microalbuminuria and cardiovascular autonomic dysfunction independently associated with cardiovascular mortality : evidence for distinct pathways : the Hoorn Study? ### Response:
Both microalbuminuria and C-AD are independently associated with cardiovascular mortality, and the excess mortality attributable to microalbuminuria cannot be explained by C-AD.
### Instruction: Is fertilization rate an independent predictor of implantation rate? ### Response:
Fertilization is a strong, independent predictor of implantation rate and may be useful in modeling to guide decision making for the number of embryos to transfer.
### Instruction: Do feasibility of using tissue Doppler velocities in stress echo during upright bicycle exercise? ### Response:
Tissue velocities decreased from base to apex. Mean difference between the raters was-0.02 cm/sec at rest and 0.45 cm/sec during exercise. Peak-to-peak variability was lowest in the mitral ring during rest (10-14%) and increased at peak exercise (15-21%). The proportion of segments eligible for analysis was 84% in the septum and 67% in the anterior wall during exercise. Thus, in patients with normal coronary arteries, tissue Doppler velocities decrease from base toward the apex during bicycle exercise. Interrater agreement is reduced during exercise and beat-to-beat variability is lowest in the mitral ring.
### Instruction: Are joystick interfaces suitable for robotized endoscope applied to NOTES? ### Response:
Applying robotics to a flexible endoscope fails to enhance ability to move into the abdominal cavity, partly because of the interface. To overcome the limitations of endoscope when performing complex NOTES tasks, robotics may be useful, especially to control the instruments and to stabilize the endoscope itself.
### Instruction: Do urine analysis and protein networking identify met as a marker of metastatic prostate cancer? ### Response:
Urinary met may provide a noninvasive biomarker indicative of metastatic prostate cancer and may be a central regulator of multiple pathways involved in prostate cancer progression.
### Instruction: Are paternal depressive symptoms during pregnancy related to excessive infant crying? ### Response:
Our findings indicate that paternal depressive symptoms during pregnancy might be a risk factor for excessive infant crying. This finding could be related to genetic transmission, interaction of a father with lasting depressive symptoms with the infant, or related indirectly through contextual stressors such as marital, familial, or economic distress.
### Instruction: Does an ultrasound-assisted approach facilitate spinal anesthesia for total joint arthroplasty? ### Response:
Ultrasound imaging of the lumbar spine provides clinically useful information that can facilitate spinal anesthesia in the older orthopedic patient population.
### Instruction: Is urinary free cortisone , but not cortisol , associated with urine volume in severe obesity? ### Response:
In severe obesity, in contrast to normal weight, renal excretion of UFE, but not of UFF is affected by fluid intake. This discrepancy may be due to the increased renal 11beta-HSD2 activity in obesity.
### Instruction: Does soluble CD40 ligand induce human coronary artery smooth muscle cells proliferation and migration? ### Response:
This study suggests that sCD40L increases VSMC proliferation and migration through the MMP-9 pathway, which may be a potential mechanism through which sCD40L induces intimal hyperplasia and atherosclerosis.
### Instruction: Does adenovirus-mediated overexpression of human tissue plasminogen activator prevent peritoneal adhesion formation/reformation in rats? ### Response:
Administration of adenovector encoding htPA is safe and decreased de novo and recurrent peritoneal adhesions.
### Instruction: Does chlamydia pneumoniae hide inside apoptotic neutrophils to silently infect and propagate in macrophages? ### Response:
Taken together, our data suggest that C. pneumoniae uses neutrophil granulocytes to be silently taken up by long-lived macrophages, which allows for efficient propagation and immune protection within the human host.
### Instruction: Do cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers? ### Response:
Down-regulation of osteopontin, probably through blockade of NR4A2 and Wnt signaling, is an important component of the antitumor activity of cyclooxygenase-2 inhibitors. These factors might be developed as therapeutic targets for intestinal cancers.
### Instruction: Does deletion of TRPC4 and TRPC6 in mice impair smooth muscle contraction and intestinal motility in vivo? ### Response:
In intestinal smooth muscle cells TRPC4 and TRPC6 channels are gated by muscarinic receptors and are responsible for mI(CAT). They couple muscarinic receptors to depolarization of intestinal smooth muscle cells and voltage-activated Ca(2+)-influx and contraction, and thereby accelerate small intestinal motility in vivo.
### Instruction: Does the ets-domain transcription factor Spdef promote maturation of goblet and paneth cells in the intestinal epithelium? ### Response:
Spdef acts downstream of Math1 to promote terminal differentiation of a secretory progenitor pool into Paneth and goblet cells.
### Instruction: Does c-Jun N-terminal kinase-1 from hematopoietic cells mediate progression from hepatic steatosis to steatohepatitis and fibrosis in mice? ### Response:
jnk1(-/-) mice are resistant to diet-induced steatohepatitis and liver fibrosis. JNK1 in hematopoietic cells, especially in Kupffer cells, contributes to the development of liver fibrosis by inducing chronic inflammation.
### Instruction: Does peroral endoscopic anastomotic reduction improve intractable dumping syndrome in Roux-en-Y gastric bypass patients? ### Response:
Endoscopic anastomotic reduction appears technically feasible and safe and might be a minimally invasive treatment option for patients who experience intractable dumping symptoms after Roux-en-Y gastric bypass. Additional studies are needed to determine the long-term efficacy of this procedure.
### Instruction: Does syndecan-1 enhance the endometrial cancer invasion by modulating matrix metalloproteinase-9 expression through nuclear factor kappaB? ### Response:
These findings provide evidence that supports that syndecan-1 may have a critical role in carcinogenic progression, particularly, contributing to the development of proliferative and invasive phenotype through NF-kappaB-mediated MMP-9 gene expression in endometrial cancer.
### Instruction: Does thickness of CAD-CAM composite resin overlay influences fatigue resistance of endodontically treated premolars? ### Response:
Thick FiltekMZ100 composite resin onlays showed higher fatigue resistance than thin ones and may be associated with fractures that are less subgingival.
### Instruction: Are the metabolism and pharmacokinetics of isotretinoin in patients with acne and rosacea influenced by ethanol? ### Response:
The metabolism and pharmacokinetics of isotretinoin and its main metabolites are not influenced by ethanol during long-term isotretinoin treatment. After ceasing long-term isotretinoin therapy the recommended period of 1 month for using anticonceptive measures in fertile women seems adequate.
### Instruction: Do budesonide and formoterol inhibit inflammatory mediator production by bronchial epithelial cells infected with rhinovirus? ### Response:
BUD and FORM suppress RV-induced chemokines and growth factors in bronchial epithelial cells in a concentration-dependent, synergistic or additive manner. These data further support the combined use of BUD and FORM in asthma and COPD and intensification of this therapy during exacerbations.
### Instruction: Does timothy grass pollen major allergen Phl p 1 activate respiratory epithelial cells by a non-protease mechanism? ### Response:
We conclude that under physiological conditions Phl p 1 affects tracheal epithelial cells through a non-proteolytic activity. Enhancement of TGF-beta expression induced by Phl p 1 together with the increased release of IL-6 and IL-8 might provide an indirect mechanism through which the allergen may cross the epithelial barrier and attracts immunocompetent cells.
### Instruction: Are chronic obstructive pulmonary disease patients with psychiatric disorders at greater risk of exacerbations? ### Response:
Patients with psychiatric disorders are at greater risk of exacerbations treated in an outpatient setting but not those treated in an inpatient setting. These outpatient-managed exacerbations account for a significant proportion of the healthcare burden for COPD, so interventions should target patients with psychiatric disorders to improve management of COPD.
### Instruction: Is health seeking behaviour of parents of burned children in Bangladesh related to family socioeconomics? ### Response:
Education, economic condition and place of residence were found as the contributory factors in choosing service provider. Education to the parents can contribute in changes in health seeking behaviour which ultimately contribute in reducing morbidity and mortality from childhood burn injuries. Including parent's education a national burn prevention program needs to be developed to combat the devastating child injury, burn.
### Instruction: Is emergency Department Ultrasound a Sensitive Detector of Solid Organ Injury? ### Response:
Emergency ultrasound is not sensitive or specific for detecting liver or spleen injuries following blunt abdominal trauma.
### Instruction: Do endodontic and salivary isolates of Enterococcus faecalis integrate into biofilm from human salivary bacteria cultivated in vitro? ### Response:
These results led to the suggestion that E. faecalis could persist in the biofilm of the human oral cavity. Because of the ubiquitous presence of E. faecalis, root canal infections may arise from different sources.
### Instruction: Is serum phosphate an important determinant of corrected serum calcium in end-stage kidney disease? ### Response:
Because guidelines recommendations indicate that corrected serum calcium should be maintained within the normal range in ESKD patients, inclusion of phosphate to correct Ca(tot) in these patients may have clinical implications on the choice of phosphate binders and the prescription of vitamin D or calcimimetic agents.
### Instruction: Is short sleep duration associated with a blood pressure nondipping pattern in type 1 diabetes : the DIAPASOM study? ### Response:
Dipping status in type 1 diabetes was associated with longer sleep duration and with hypoglycemia unawareness.
### Instruction: Do a qualitative study on patient perspectives of how conventional and implant-supported dentures affect eating? ### Response:
In conclusion, issues surrounding eating are a major concern for edentulous patients. The main impacts of edentulousness are limitation of social participation and food choice. The functional improvement and increased social confidence that ISODs can provide, has a beneficial impact on this aspect of patients of quality of life.
### Instruction: Do glioblastoma cells express functional cell membrane receptors activated by daily used medical drugs? ### Response:
Our study impressively demonstrates that medical drugs are potent inducers of intracellular calcium signals. Totally unexpected, the results show a high amount of functional cellular receptors and channels on glioma cells, which could be responsible for certain biological effects like migration and cell growth. This calcium imaging study proves the usability of the calcium imaging as a screening system for functional receptors on human glioma cells.
### Instruction: Does nifedipine interfere with migration of vascular smooth muscle cells via inhibition of Pyk2-Src axis? ### Response:
These data suggest that nifedipine interferes with VSMC migration via inhibition of the Pyk2-Src axis and inhibition of actin remodeling processes, including membrane ruffling and lamellipodium formation.
### Instruction: Does genistein in the presence of 17beta-estradiol inhibit proliferation of ERbeta breast cancer cells? ### Response:
Our results suggest that in cells with a predominance of ERalpha, genistein acts as an agonist to ERalpha, and in cells with ERbeta alone, genistein most likely acts as an antiestrogen. Our results also suggest that genistein could be useful as a chemotherapeutic agent in premenopausal women with breast cancer of the ERalpha-negative and ERbeta-positive type.
### Instruction: Does lidocaine inhibit epithelial chemokine secretion via inhibition of nuclear factor kappa B activation? ### Response:
Lidocaine inhibits IL-8 and IP-10 secretion from intestinal cells. This effect is mediated by inhibition of NFkappaB activation via decreased IkappaB phosphorylation and is not mediated by lidocaine's effect on VGSC.
### Instruction: Does plasma TF activity predict cardiovascular mortality in patients with acute myocardial infarction? ### Response:
Systemic TF activity in AMI has an unfavorable prognostic value and as a marker for dysregulated coagulation may add to predict the atherothrombotic risk.
### Instruction: Does the relationship of clinical laboratory parameters and patient attribute to the quality of life of patients on hemodialysis? ### Response:
The serum potassium level significantly affected not only physical health, but also QOL, a measure of psychosocial health. This suggests that providing nursing support to patients, guided by the serum potassium target range of 3.5-5.0 mEq/L, might improve and maintain QOL.
### Instruction: Are women , patients with severe asthma , and patients attended by primary care physicians , at higher risk of suffering from poorly controlled asthma? ### Response:
After model adjustment, we suggest that being female, suffering from more severe asthma, or being attended by a primary care physician, could pose a significantly higher risk of having poorly controlled asthma in adults.
### Instruction: Does tafluprost protect rat retinal ganglion cells from apoptosis in vitro and in vivo? ### Response:
These data suggest that tafluprost has an anti-apoptotic effect in RGCs.
### Instruction: Is t2 at MR imaging an objective quantitative measure of cerebral white matter signal intensity abnormality in preterm infants at term-equivalent age? ### Response:
Cerebral WM T2 is an objective quantitative measurement that can easily and rapidly be obtained during clinical MR imaging in preterm infants at term.
### Instruction: Does combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induce apoptosis in colon cancer HT29 cells? ### Response:
Our results suggest that isoliquiritigenin has the potential to overcome resistance to TRAIL in cancer cells and its chemopreventive effects may depend on TRAIL function.
### Instruction: Does the specificity of tests for anti-beta-lactam IgE antibodies decline progressively with increase of total serum IgE? ### Response:
Before 2006, tests for anti-beta-lactam IgE antibody in patients with total IgE > 500 kU/l were probably often false positive. Patients who were diagnosed as penicillin allergic before 2006 solely on the basis of a positive CAP FEIA test for specific IgE should be considered for diagnostic reevaluation.
### Instruction: Do concurrent growth rate and transcript analyses reveal essential gene stringency in Escherichia coli? ### Response:
RNA silencing can reveal stringent requirements for gene expression with respect to growth. This method may be used to validate existing essential genes and to quantify drug target requirement.
### Instruction: Is bacterial antigen expression an important component in inducing an immune response to orally administered Salmonella-delivered DNA vaccines? ### Response:
These findings suggest that prokaryotic expression of the antigen and co-delivery of this protein by Salmonella are at least partially responsible for the successful oral delivery of C-fragment DNA vaccines containing the CMV promoter by S. typhimurium.
### Instruction: Does physical training in patients on hemodialysis have a beneficial effect on the levels of eicosanoid hormone-like substances? ### Response:
The data indicate that exercise training during HD exerts a beneficial effect on the levels of the vasoactive eicosanoid hormone-like substances in patients on HD.
### Instruction: Do single-copy nuclear genes resolve the phylogeny of the holometabolous insects? ### Response:
These findings provide the most complete evolutionary framework for future comparative studies on holometabolous model organisms and contribute strong evidence for the resolution of the 'Strepsiptera problem', a long-standing and hotly debated issue in insect phylogenetics.
### Instruction: Do endogenous TasiRNAs mediate non-cell autonomous effects on gene regulation in Arabidopsis thaliana? ### Response:
Endogenous tasiRNAs are thus mediators of a mobile developmental signal and might provide effective gene silencing at a distance beyond the reach of most miRNAs.
### Instruction: Is a thymic stromal lymphopoietin gene variant associated with asthma and airway hyperresponsiveness? ### Response:
A genetic variant in the region of the thymic stromal lymphopoietin gene is associated with the phenotypes of asthma and airway hyperresponsiveness.