Datasets:
typosonlr
/
PubMedPreProcessed

Dataset card Data Studio Files
xet
Community
1
question
stringlengths
52
373
long_answer
stringlengths
1
3.34k
### Instruction: Does the phospholipase A ( 2 ) inhibitor methyl indoxam suppress diet-induced obesity and glucose intolerance in mice? ### Response:
These results show that oral supplementation of a diabetogenic diet with the Pla2g1b inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes in mice. This suggests that Pla2g1b inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.
### Instruction: Do physiological thyroid hormone levels regulate numerous skeletal muscle transcripts? ### Response:
We demonstrated that physiological levels of TH regulate a myriad of genes in human skeletal muscle. The identification of novel putatively TH-responsive genes may provide the molecular basis of clinical effects in subjects with different TH status. The observation that TH regulates microRNAs reveals a new layer of complexity by which TH influences cellular processes.
### Instruction: Does evaluation of a new device to prevent fall in persons with Parkinson 's disease? ### Response:
The WalkAbout may help persons with PD who have more severe disability to walk farther. These data could be beneficial in selecting a helpful walking aid for persons with PD.
### Instruction: Does higher inpatient medical surgical bed occupancy extend admitted patients ' stay? ### Response:
Med/surg bed occupancy has a better correlation to extended transfer times, and occupancy over 92% at 5 AM in our institution corresponds to an increased frequency of extended transfer times from the ED. The process of ED evaluation, hospital admission, and subsequent transfer into the hospital are all complex processes. This study begins to demonstrate one variable, med/surg occupancy, as one of the intervals that can be followed to evaluate the process of ED admission and hospital flow.
### Instruction: Is routine laboratory testing to evaluate for medical illness in psychiatric patients in the emergency department largely unrevealing? ### Response:
Patients presenting to the ED with psychiatric chief complaints, benign histories and normal physical exams have a low likelihood of clinically significant laboratory findings.
### Instruction: Is copper-induced regression of cardiomyocyte hypertrophy associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway? ### Response:
Enhanced VEGFR-1 signalling is involved in Cu regression of cardiomyocyte hypertrophy, and the PKG-1 pathway is likely associated with VEGFR-1.
### Instruction: Does myocardial electrical activity affect myocardial electrical impedance measurements? ### Response:
These results demonstrate that our MEI monitor is unaffected by the frequency of the periodic myocardial electrical activity that generates the HR.
### Instruction: Is blood pressure elevated in children with primary snoring? ### Response:
PS was demonstrated to be an aspect of the dose-response relationship between SDB and BP in children and should not be considered completely benign.
### Instruction: Does adult male circumcision reduce the risk of incident Neisseria gonorrhoeae , Chlamydia trachomatis , or Trichomonas vaginalis infection : results from a randomized , controlled trial in Kenya? ### Response:
Circumcision of men in this population did not reduce their risk of acquiring these nonulcerative STIs. Improved STI control will require more-effective STI management, including partner treatment and behavioral risk reduction counseling.
### Instruction: Is cardiomyopathy associated with structural remodelling of heart valve extracellular matrix? ### Response:
Valves from cardiomyopathic hearts showed significant ECM deterioration with a disrupted collagen and elastic fibre network. It will be important to determine the impact of this ECM damage on valve durability and calcification in vivo if allografts are to be used from these donors.
### Instruction: Does recent evidence support emotion-regulation interventions for improving health in at-risk and clinical populations? ### Response:
Evidence generally supports the use of a variety of emotion-regulation interventions to improve health and well being in at-risk and clinical populations, although factors related to treatment response warrant additional research.
### Instruction: Is release of developmental constraints on tetrad shape confirmed in inaperturate pollen of Potamogeton? ### Response:
The data support the view that there is a correlation between the inaperturate pollen production and the release of constraint on tetrad shape. However, in P. pusillus the tetrad shape may be constrained by a callose ring. It is also suggested that the lack of apertures in the pollen of Potamogeton may be due to the lack of specific sites on which callose deposition is completed. Moreover, inaperturate pollen of Potamogeton would be better classified as omniaperturate.
### Instruction: Does lactate dehydrogenase-elevating virus induce systemic lymphocyte activation via TLR7-dependent IFNalpha responses by plasmacytoid dendritic cells? ### Response:
Results indicate that LDV-induced activation of lymphocytes is due to recognition of LDV nucleic acid by TLR7 pattern recognition receptors in pDC's that respond with a lymphocyte-inducing IFNalpha response.
### Instruction: Is yes-associated protein an independent prognostic marker in hepatocellular carcinoma? ### Response:
YAP is an independent prognostic marker for overall survival and disease-free survival times of HCC patients and clinicopathologically associated with tumor differentiation and serum AFP level. It is a potential therapeutic target for this aggressive malignancy.
### Instruction: Does the Manchester Triage System provide good reliability in an Australian emergency department? ### Response:
The MTS is a reliable system of triage in the emergency department.
### Instruction: Does serial bedside B-type natriuretic peptide strongly predict prognosis in acute coronary syndrome independent of echocardiographic abnormalities? ### Response:
In ACS, bedside BNP levels predict CV events at 10 months, independent of many echocardiographic abnormalities including LVH. Furthermore, our study suggests that an additional 7 weeks post ACS BNP enhances risk stratification over and above a one-off high BNP at baseline.
### Instruction: Do both host and graft vessels contribute to revascularization of xenografted human ovarian tissue in a murine model? ### Response:
Host and graft vessels contributed sequentially to graft revascularization: murine angiogenesis initiated reperfusion from day 5 and, by day 10, human angiogenesis was shown to participate in graft revascularization. Host and graft angiogenesis are potential targets to reduce the avascular period after grafting.
### Instruction: Do combined effects of obesity and type 2 diabetes contribute to increased breast cancer risk in premenopausal women? ### Response:
Obesity and type 2 diabetes, owing to their effects on adipocytokines and inflammatory mediators, contribute to increased breast cancer risk in premenopausal women. This study emphasizes healthy life style and better management of these metabolic disorders to avoid the pathogenesis of breast cancer and of other chronic diseases.
### Instruction: Is addition of rituximab associated with survival benefit compared with CHOP alone for patients with stage I diffuse large B-cell lymphoma? ### Response:
CHOP alone could be as effective as R-CHOP regimen and additional radiotherapy would be necessary for stage I or stage I non-bulky DLBCL patients.
### Instruction: Is higher education associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity : results from the EIRA cohort and Swedish rheumatology register? ### Response:
In Sweden, with tax-financed, generally accessible healthcare system, RA patients with a high education level experienced less pain and less functional disability. Further, these patients achieved pain remission more often during the first year receiving standard care. Importantly, education background affected neither time to referral to rheumatologists, disease activity nor anti-rheumatic treatments.
### Instruction: Does eGCG attenuate Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway? ### Response:
In summary, our findings indicated that Notch-1 plays an important role in the UA-induced inflammatory response, and the downregulation of Notch-1 by EGCG could be an effective approach to decrease inflammation and oxidative stress induced by UA.
### Instruction: Is dNA-methylation in C1R a prognostic biomarker for acute myeloid leukemia? ### Response:
Analysis of DNAm at C1R provides a simple, robust, and cost-effective biomarker to further complement risk assessment in AML.
### Instruction: Is prediction of critical weight loss during radiation treatment in head and neck cancer patients dependent on BMI? ### Response:
Pre-treatment BMI, tumor site and stage predicted weight loss above 5 % in HNSCC patients during radiotherapy. BMI should be considered when analyzing weight loss in HNSCC patients receiving curative radiotherapy.
### Instruction: Does pRL-3 promote gastric cancer migration and invasion through a NF-κB-HIF-1α-miR-210 axis? ### Response:
PRL-3 regulates microRNA in gastric cancer. PRL-3 elevates hsa-miR-210 by upregulating HIF-1α. PRL-3 activates a NF-κB-HIF-1α-miR-210 axis by enhancing the phosphorylation of p65. PRL-3 promotes cell migration and invasion via the NF-κB-HIF-1α-miR-210 axis. High levels of PRL-3 and miR-210 are related with poor OS in gastric cancer.
### Instruction: Do calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease? ### Response:
This integrative genomic study confirmed the role of RUNX2 as a potential driver of AS and identified a new AS susceptibility gene, CACNA1C, belonging to the calcium signaling pathway.
### Instruction: Does a Dipeptidyl Peptidase-4 Inhibitor but not Incretins suppress Abdominal Aortic Aneurysms in Angiotensin II-Infused Apolipoprotein E-Null Mice? ### Response:
DPP-4I, MK0626, but not native incretins has protective effects against AAA in Ang II-infused Apoe－/－ mice via suppression of inflammation, proteolysis, and fibrosis in the aortic wall.
### Instruction: Do lack of Acute Hand Care in the Southwest United States? ### Response:
Patients transferred for acute hand care were young and male, and traveled an average 51 miles to get to our center. More than half of these patients were treated and discharged from our ED. This indicates that a majority may have been managed in a clinic setting. Most EDs in our region do not have a hand surgeon available. Most emergency physicians surveyed had received little training in management of acute hand injuries and hand infections. Further research is needed to identify methods to remove barriers to provision of care for patients with hand trauma.
### Instruction: Is nedd4L expression decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue? ### Response:
Nedd4L protein expression may be an independent prognostic marker of ovarian cancer development.
### Instruction: Is osteopontin a proximal effector of leptin-mediated non-alcoholic steatohepatitis ( NASH ) fibrosis? ### Response:
OPN overexpression in NASH enhances leptin-mediated fibrogenesis via PI3K/Akt. OPN neutralization significantly reduces NASH fibrosis, reinforcing the potential utility of targeting OPN in the treatment of patients with advanced NASH.
### Instruction: Does a20 suppress hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression? ### Response:
Our results demonstrate that A20 plays a negative role in the development and progression of HCC probably through inhibiting Twist1 expression. A20 may serve as a novel prognostic biomarker and potential therapeutic target for HCC patients.
### Instruction: Does endothelial β-Catenin Signaling be Required for Maintaining Adult Blood-Brain Barrier Integrity and Central Nervous System Homeostasis? ### Response:
These results demonstrate the prerequisite role of endothelial β-catenin in maintaining the integrity of adult BBB. The results suggest that BBB dysfunction secondary to defective β-catenin transcription activity is a key pathogenic factor in hemorrhagic stroke, seizure activity, and central nervous system inflammation.
### Instruction: Is unplanned return to operating room after lower extremity arterial bypass an independent predictor for hospital readmission? ### Response:
Readmission after lower extremity bypass surgery is a serious complication. Various factors put a patient at high risk for readmission. Return to the operating room, wound infection, amputation, deep venous thrombosis, and major reintervention on bypass are independent risk factors for hospital readmission. Return to the operating room is associated with a 5.95-fold increase in hospital readmission.
### Instruction: Does aganglionosis with the absence of hypertrophied nerve fibres predict disease proximal to rectosigmoid colon? ### Response:
The absence of nerve fibre hypertrophy in the presence of aganglionosis on rectal biopsy specimens is predictive of long-segment HSCR.
### Instruction: Does prevalence and correlate of Hazardous Drinking among Female Sex Workers in 13 Mexican Cities? ### Response:
Findings support the high prioritization by public health authorities of alcohol prevention and treatment programs for FSWs.
### Instruction: Is twin vaginal delivery associated with lower umbilical arterial blood pH of the second twin and less intrapartum blood loss? ### Response:
Twin vaginal deliveries were associated with slightly but significantly lower UmA-pH of the second twin, whereas twin cesarean delivery was associated with significantly larger intrapartum blood loss. Not only the neonatal risk but also the maternal risk should be taken into account when an optimal delivery mode for the twin pregnancy is considered.
### Instruction: Does microsomal Prostaglandin E Synthase-1-Derived PGE2 inhibit Vascular Smooth Muscle Cell Calcification? ### Response:
Our data revealed the pivotal role of COX-2-mPGES-1-PGE2 axis in vascular calcification. The selective inhibition of COX-2 or mPGES-1 may increase the risk of calcification and subsequent adverse cardiovascular events during chronic renal failure.
### Instruction: Does [ MicroRNA-33a regulate the invasion of cervical cancer cells via targeting Twist1 ]? ### Response:
Twist1 is critical for the invasiveness of cervical cancer cells; miR-33a, as a tumor suppressor gene, functions as an upstream regulator of Twist1 and is involved in the invasiveness of cervical cancer cell.
### Instruction: Does [ MiRNA-381 inhibit the invasion of renal carcinoma and the underlying mechanisms ]? ### Response:
MiRNA-381 can inhibit cell invasion in renal cancer by block the function of CBP, β-catenin and LEF-1.
### Instruction: Does deletion of aquaporin-4 in APP/PS1 mice exacerbate brain Aβ accumulation and memory deficits? ### Response:
These results suggest that AQP4 attenuates Aβ pathogenesis despite its potentially inflammatory side-effects, thus serving as a promising target for treating AD.
### Instruction: Does umbilical cord gene expression reveal the molecular architecture of the fetal inflammatory response in extremely preterm newborns? ### Response:
The FIR expression signature in UC tissue contains molecular clues about signaling pathways that trigger FIR, and it is consistent with an acute inflammatory response by fetal innate and adaptive immune systems, which participate in the pathogenesis of neonatal brain damage.
### Instruction: Does active Maintenance of the Gradient of Refractive Index be Required to Sustain the Optical Properties of the Lens? ### Response:
The cellular physiology of the lens actively maintains its optical properties and inhibiting the Na/K/ATPase induces a myopic shift in vision similar to that observed clinically in patients who go on to develop cataract.
### Instruction: Are higher levels of procoagulant microparticles in women with recurrent miscarriage associated with antiphospholipid antibodies? ### Response:
cMPs in women with RM are not associated with antiphospholipid antibodies (aPLs).
### Instruction: Is meis2 essential for cranial and cardiac neural crest development? ### Response:
Meis2-null mice are embryonic lethal. Our results reveal a critical role of Meis2 during cranial and cardiac neural crest cells development in mouse.
### Instruction: Does endostatin exert radiosensitizing effect in non-small cell lung cancer cells by inhibiting VEGFR2 expression? ### Response:
Endostatin induces apoptosis and enhances radiosensitivity of the VEGFR2 high-expressing cell line Calu-1, but it has a limited effect on the VEGFR2 low-expressing cell line A549.
### Instruction: Does software-Based Hybrid Perfusion SPECT/CT provide Diagnostic Accuracy When Other Pulmonary Embolism Imaging Is Indeterminate? ### Response:
Q-SPECT/CT improves the diagnostic rate with promising accuracy in diagnosing PE that yields a satisfactory clinical verdict, especially when the CTPA and planar V/Q scan are indeterminate.
### Instruction: Does impaired GLP-1 signaling contribute to reduced sensitivity to duodenal nutrients in obesity-prone rats during high-fat feeding? ### Response:
Susceptibility to obesity coupled with HF feeding results in rapid impairments in nutrient-induced satiation through blunted responses in endogenous GLP-1 and hindbrain vagal afferent signaling.
### Instruction: Does fasudil alleviate traumatic optic neuropathy by inhibiting Rho signaling pathway? ### Response:
The present study demonstrates that fasudil inhibits the apoptosis of retinal ganglion cells and ameliorates damages of optic nerves in traumatic optic neuropathy.
### Instruction: Does eRRα be a Marker of Tamoxifen Response and Survival in Triple-Negative Breast Cancer? ### Response:
Taken together, these data show that ERRα expression predicts response to tamoxifen treatment, and ERRα could be a biomarker of tamoxifen sensitivity and a prognostic factor in TNBC.
### Instruction: Does microRNA-340 mediate Metabolic Shift in Oral Squamous Cell Carcinoma by Targeting Glucose Transporter-1? ### Response:
The findings suggest that miR-340 might act as a molecular switch that contributes to the regulation of glycolysis in OSCC by regulating Glut1 expression.
### Instruction: Does estrogen receptor α ( ESR1 ) IVS1-397T > C polymorphism lower risk of fracture? ### Response:
The meta-analysis demonstrates that risk of fracture seems likely to be decreased due to IVS1-397 CC or CT genotype.
### Instruction: Is willis-Ekbom disease associated with poor cardiovascular health in adults? ### Response:
In adult Amerindians, although obesity and body mass index were associated with WED/RLS on univariate analyses, the association was not present after adjustment for confounders. No other significant associations were found between WED/RLS and AHA cardiovascular metrics.
### Instruction: Is idiopathic Cam Morphology Caused by Subclinical Slipped Capital Femoral Epiphysis : An MRI and CT Study? ### Response:
The proximal femoral growth plate normally has a posterior tilt that becomes more anterior through maturation. Idiopathic cam morphology has a drastically different growth plate tilt angle than cam morphology secondary to SCFE, suggesting that a majority of idiopathic cam morphology is not the result of subclinical SCFEs.
### Instruction: Does tNF accelerate Death of Mandibular Condyle Chondrocytes in Rats with Biomechanical Stimulation-Induced Temporomandibular Joint Disease? ### Response:
Unilateral anterior crossbite stimulation induces mitochondrion-mediated apoptosis of articular chondrocytes. TNF accelerated the unilateral anterior crossbite induced chondrocytes apoptosis via death-receptor pathway. However, anti-TNF therapy does not prevent cartilage loss in this model of temporomandibular joint.
### Instruction: Does g-8 indicate overall and quality-adjusted survival in older head and neck cancer patients treated with curative radiochemotherapy? ### Response:
G-8 is indicative of quality-adjusted survival, and should be considered at time of treatment decisions for the older HNCA patient.
### Instruction: Does an environmental route of exposure affect the formation of nanoparticle coronas in blood plasma? ### Response:
This work shows how a self-assembling protein, class II hydrophobin HFBII, with interesting biocompatible coating properties, strongly adsorbs on polystyrene NPs. HFBII is also shown to reduce aggregation of the NPs in human plasma which can increase their bioavailability with potential use in biomedical applications. The results here are also of significance for understanding possible interactions of NPs with living organisms. Hydrophobins are secreted in large quantities into the environment by fungi and this work shows how the biological environment of NPs determines the surface and colloidal properties of the particles by forming a protein corona, and that the history of the particle environment, here simulated with hydrophobin exposure, affects both plasma protein corona formation and dispersion behavior. This work thus simulates how alternative exposure routes affect nanoparticle properties, important in understanding the biological fate of NPs.
### Instruction: Does combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kill cancer cells? ### Response:
These results suggest that inhibitors targeting the NHEJR pathway could significantly enhance radiosensitivity of human cancer cells to C ion irradiation, rather than targeting the HRR pathway.
### Instruction: Does microRNA profiling unveil hyperglycaemic memory in the diabetic heart? ### Response:
Glycaemic control is not able to rescue hyperglycaemia-induced alterations of miRNA landscape in the diabetic heart. These findings may provide novel insights to understand why diabetic cardiomyopathy progresses despite normalization of blood glucose levels.
### Instruction: Does tSG101 Silencing suppress Hepatocellular Carcinoma Cell Growth by Inducing Cell Cycle Arrest and Autophagic Cell Death? ### Response:
TSG101 plays an important role in the development of HCC and may be a target for molecular therapy.
### Instruction: Is concomitant lamotrigine use associated with decreased efficacy of the ketogenic diet in childhood refractory epilepsy? ### Response:
Lamotrigine treatment during KD is associated with a decreased efficacy of the KD.
### Instruction: Do macrophages dictate the progression and manifestation of hypertensive heart disease? ### Response:
Macrophages mediate the development of hypertension, LVH, adverse cardiac remodeling, and fibrosis. Macrophages, therefore, should be considered as a therapeutic target to reduce the adverse consequences of hypertensive heart disease.
### Instruction: Are procedure Delays and Time of Day Associated With Reductions in Quality of Screening Colonoscopies? ### Response:
Procedure delays and measured factors associated with fatigue, including time of day and multiple procedure blocks, do not reduce the odds of detecting an adenoma. Adenoma detection varies widely among providers, so efforts to improve adenoma detection should focus mainly on optimizing physician skill.
### Instruction: Do surgical management of damaged inferior alveolar nerve caused by endodontic overfilling of calcium hydroxide paste? ### Response:
The results of this case series confirmed the notion that surgical management of the inferior alveolar nerve is effective in the treatment of nerve injuries caused by endodontic extrusion of calcium hydroxide paste. Delayed surgical repair of the inferior alveolar nerve can be indicated and helpful for the neurosensory recovery of damaged IAN, however, the surgical management was less effective in case of widespread nerve injuries.
### Instruction: Is standards and guidelines for observational studies : quality in the eye of the beholder? ### Response:
The lack of observational study standard/guideline agreement may contribute to variation in study conduct; disparities in what is considered credible research; and ultimately, what evidence is adopted. A common set of agreed on standards/guidelines for conducting observational studies will benefit funders, researchers, journal editors, and decision makers.
### Instruction: Does isorhamnetin protect mice from lipopolysaccharide-induced acute lung injury via the inhibition of inflammatory responses? ### Response:
Isor showed efficient protective effects on an LPS-induced ALI model. MAPKs and NF-κB pathways are critical for Isor to perform its protective effects.
### Instruction: Does the ileal bile acid transporter inhibitor A4250 decrease serum bile acids by interrupting the enterohepatic circulation? ### Response:
A4250 is well tolerated. By blocking ileal bile acid transporter in the terminal ileum, it highly efficiently interrupts the enterohepatic circulation of BAs, and should be of benefit to patients with cholestatic liver diseases. Clinical Trial registration EudraCT 2013-001175-21.
### Instruction: Is narrow band CE-Chirp auditory steady-state response more reliable than the conventional ASSR in predicting the behavioral hearing threshold? ### Response:
NB CE-Chirp ASSR generally revealed more favorable outcomes. However, its reliability was reduced at lower frequencies and in patients with milder hearing loss.
### Instruction: Are infectious diseases associated with carotid intima media thickness in adolescence? ### Response:
The SAPALDIA Youth study complements current evidence on infectious origins of atherosclerosis in adults. The larger effects observed in boys may relate to a higher vulnerability of the vasculature and/or to infectious pathogens. Our data are suggestive of an early impact of childhood infectious diseases on vascular health.
### Instruction: Do apolipoprotein E-deficient rats develop atherosclerotic plaques in partially ligated carotid arteries? ### Response:
The ApoE(-/-) rat is a novel model for dyslipidemia and could also be used in the research of atherosclerosis.
### Instruction: Do dual inhibition of nuclear factor kappa-B and Mdm2 enhance the antitumor effect of radiation therapy for pancreatic cancer? ### Response:
Combination therapy of radiation with nafamostat mesilate exerts enhanced anti-tumor effect against human pancreatic cancer.
### Instruction: Does apelin-13 protect the heart against ischemia-reperfusion injury through the RISK-GSK-3β-mPTP pathway? ### Response:
The protective mechanism of apelin-13 might be that inactivation of GSK-3β could inhibit the opening of mPTP by activating PI3K/Akt and ERK1/2 involved in the reperfusion injury salvage kinase (RISK) pathway.
### Instruction: Do simultaneous multi-slice readout-segmented echo planar imaging for accelerated diffusion-weighted imaging of the breast? ### Response:
SMS rs-EPI yields similar ADC values and SNR compared to conventional rs-EPI at markedly reduced scan time. Thus, SMS excitation increases the clinical applicability of rs-EPI for DWI of the breast.
### Instruction: Does minimally Invasive Pancreaticoduodenectomy Improve Use or Time to Initiation of Adjuvant Chemotherapy for Patients With Pancreatic Adenocarcinoma? ### Response:
At a national level, MI-PD does not result in greater use or earlier initiation of adjuvant chemotherapy. As surgeons and institutions continue to gain experience with this complex procedure, it will be important to revisit this benchmark as a justification for its increasing use for patients with pancreatic cancer.
### Instruction: Does notch-1 promote breast cancer cells proliferation by regulating LncRNA GAS5? ### Response:
Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5.
### Instruction: Does steroid treatment resolve acute respiratory failure in patient transferred for ECMO? ### Response:
In the right patient population, IV steroid treatment can avoid further deterioration of end-stage respiratory failure.
### Instruction: Do term neonates with infection and shock display high cortisol precursors despite low levels of normal cortisol? ### Response:
Septic newborn infants with therapy-resistant hypotension had very high DHEA levels, suggesting that 3-beta-hydroxysteroid dehydrogenase activity limited the rate of cortisol synthesis.
### Instruction: Does aging be Accompanied by a Blunted Muscle Protein Synthetic Response to Protein Ingestion? ### Response:
Aging is associated with the development of muscle anabolic inflexibility which represents a key physiological mechanism underpinning sarcopenia.
### Instruction: Are polymorphisms of estrogen metabolism-related genes ESR1 , UGT2B17 , and UGT1A1 associated with osteoporosis in surgically menopausal Japanese women? ### Response:
These results suggest that the ESR1, UGT2B17, and UGT1A1 polymorphisms are not genetic factors affecting osteoporosis in postmenopausal Japanese women.
### Instruction: Does up-regulation of serum miR-744 predict poor prognosis in patients with nasopharyngeal carcinoma? ### Response:
Serum miR-744 was up-regulated in NPC patients. Higher expression level of serum miR-744 was closely correlated with was associated with poor prognosis in NPC and it might be employed as a potential biomarker for predicting the clinical outcome of NPC patients.
### Instruction: Does resting-state functional network connectivity in prefrontal regions differ between unmedicated patients with bipolar and major depressive disorders? ### Response:
As patients were unmedicated, the sample sizes were relatively small, although they were comparable to those in previous fMRI studies comparing BD and MDD.
### Instruction: Does 2D cine DENSE with low encoding frequencies accurately quantify cardiac mechanics with improved image characteristics? ### Response:
For 2D cine DENSE with through-plane dephasing, the encoding frequency can be lowered to 0.04 cycles/mm without compromising the quantification of twist or strain. The amount of wrapping can be reduced with this lower value to greatly simplify the input to unwrapping algorithms. The strain and twist results from studies using different encoding frequencies can be directly compared.
### Instruction: Does linc00152 promote proliferation in gastric cancer through the EGFR-dependent pathway? ### Response:
We first found that Linc00152 could promote tumor growth through EGFR-mediated PI3K/AKT pathway which may serve as potential targets for therapy in the future.
### Instruction: Does novel Manganese-Porphyrin Superoxide Dismutase-Mimetic widen the Therapeutic Margin in a Preclinical Head and Neck Cancer Model? ### Response:
MnBuOE widens the therapeutic margin by decreasing the dose of radiation required to control tumor, while increasing normal tissue resistance to RT-mediated injury. This is the first study to quantitatively demonstrate the magnitude of a single drug's ability to radioprotect normal tissue while radiosensitizing tumor.
### Instruction: Are serum Gamma-Glutamyltransferase and Ferritin Related to Insulin Resistance : A Population-Based Study? ### Response:
Insulin resistance is associated with elevated serum GGT and ferritin. A combined determination of GGT and ferritin might lead to better predictions in patients with insulin resistance.
### Instruction: Do [ Experience in the use of high-frequency selective percutaneous rhizotomy in trigeminal neuralgia associated with multiple sclerosis ]? ### Response:
These data confirm that PHFSR is a safe, repeatable, and effective method of symptomatic neurosurgical treatment of TN associated with MS and may be recommended in the case of failure/intolerance of medication.
### Instruction: Does severe cranial neuropathies caused by fall from heights in children? ### Response:
Cranial neuropathies due to falls from heights are rare in children and are associated with high visual morbidity. Vision or ocular motility impairment, especially monocular vision loss, may be missed during acute intake to the emergency department, and a high index of suspicion is needed. Assessment of the pupillary response to light is essential.
### Instruction: Does med14 cooperate with brg1 in the differentiation of skeletogenic neural crest? ### Response:
These results suggest a critical role for Mediator and BAF complex function in neural crest development, and may also clarify the nature of defects in some craniofacial abnormalities.
### Instruction: Do [ Long-term follow-up study of titanium implant impact on pediatric mandibular growth and development ]? ### Response:
The titanium plants have no significant impact on the growth and development of pediatric mandible postoperatively; hence, the question on whether the titanium plates should be removed or not may be neglected. The removal operation may lead to secondary trauma; thus, performing titanium plate removal routinely is not recommended.
### Instruction: Does arjunolic acid protect against DNCB-induced atopic dermatitis-like symptoms in mice by restoring a normal cytokine balance? ### Response:
The results indicate that AA suppresses DNCB-induced AD in mice via redox balance and immune modulation, and could be a safe clinical treatment for AD.
### Instruction: Does n2 extenuate experimental ischemic stroke through platelet aggregation inhibition? ### Response:
N2 can improve the motor function, learning and memory ability in MCAO/R rats while reducing the infarct volume. N2 can inhibit TXA2 formation but promote PGI2, and can inhibit platelet aggregation induced by U46619 and ADP. Further, N2 inhibits thrombosis with a minor adverse effect of bleeding than Clopidogrel. In conclusion, N2 can produce the protective effect on MCAO/R brain injury through inhibiting TXA2 formation, platelet aggregation and thrombosis.
### Instruction: Is the differentially methylated region of MEG8 hypermethylated in patients with Temple syndrome? ### Response:
Based on the observed MEG8-DMR DNA-hypermethylation and previously published data, we conclude that DNA-methylation of the MEG3- and MEG8-DMR is functionally dependent on the DNA-methylation pattern of the IG-DMR. The observed combination of epimutations is predicted to be associated with bi-allelic MEG3 and MEG8 expression in individuals with Temple syndrome.
### Instruction: Does catalase improve saccharification of lignocellulose by reducing lytic polysaccharide monooxygenase-associated enzyme inactivation? ### Response:
Oxidative inactivation of commercial cellulase mixtures is a significant factor influencing the overall saccharification efficiency and the addition of catalase can be used to protect these mixtures from inactivation.
### Instruction: Does purpose in life predict allostatic load ten years later? ### Response:
The current study provides the first empirical evidence for the long-term physiological correlates of life purpose and supports the hypothesis that self-health locus of control acts as one proximal psychological mechanism through which life purpose may be linked to positive biological outcomes.
### Instruction: Do gene-expression patterns in peripheral blood classify familial breast cancer susceptibility? ### Response:
Together, these findings suggest that gene-expression levels in peripheral blood cells reflect genomic variation associated with breast cancer risk and that such data have potential to be used as a non-invasive biomarker for familial breast cancer risk.
### Instruction: Is previous chronic cerebral infarction predictive for new cerebral ischemia after carotid endarterectomy? ### Response:
The results of the present study suggest that preoperative chronic cerebral ischemia may aggravate postoperative newly developed cerebral ischemia in patients undergoing CEA.
### Instruction: Does miR-362-5p promote the malignancy of chronic myelocytic leukaemia via down-regulation of GADD45α? ### Response:
miR-362-5p acts as an oncomiR that down-regulates GADD45α, which consequently activates the JNK1/2 and P38 signalling. This finding provides novel insights into CML leukaemogenesis and may help identify new diagnostic and therapeutic targets.
### Instruction: Is rs219780 SNP of Claudin 14 Gene Related to Clinical Expression in Primary Hyperparathyroidism? ### Response:
rs219780 SNP of CLDN14 does not appear to be a risk factor for the development of PHPT nor does it seem to influence the clinical expression of PHPT.
### Instruction: Is a Functional Single-Nucleotide Polymorphism in Pre-microRNA-196a2 Associated with Atrial Fibrillation in Han Chinese? ### Response:
Our data support that the pre-miR-196a2 polymorphism is associated with AF, and the C allele is a risk factor for AF.
### Instruction: Does first-Trimester Maternal Abdominal Adiposity predict Dysglycemia and Gestational Diabetes Mellitus in Midpregnancy? ### Response:
Elevated first-trimester VAT and TAT depth independently predicted the risk of dysglycemia later in pregnancy.
### Instruction: Is neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins? ### Response:
Degeneration and loss of anterior horn cells associated with expansions in C9orf72 occurs in the absence of DPR, and implies that changes involving loss of nuclear staining for and a cytoplasmic aggregation of TDP-43 are more likely to be the cause of this.
### Instruction: Is lamin A/C deficiency an independent risk factor for cervical cancer? ### Response:
Lamin A/C deficiency may serve as an independent risk factor for CIN development and as an indicator for preventive therapy in cervical cancer.