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### Instruction: Does [ SNACK HIGH WHEY PROTEIN improve THE LEVEL OF SATIETY AND REDUCES APPETITE HEALTHY WOMEN ]? ### Response:
snacks with less energy density and rich in protein (yogurt with PSL) improve the control of appetite, satiety and reduces food intake in healthy women later.
### Instruction: Is amazonian delicacy tucupi as erosive as a cola-based soft drink? ### Response:
Besides the most worldwide appreciated cola-based soft drink, the greatly consumed Amazonian delicacy tucupi can be considered a potential risk factor for tooth erosion.
### Instruction: Do instructions influence response to the Chinese version of the Movement-Specific Reinvestment Scale in community-dwelling older adults? ### Response:
Both the MSRS-C (general) and MSRS-C (walking) with a six-point or a four-point response format showed good discrimination of older fallers from non-fallers. Older adults might respond to the MSRS-C with respect to the most challenging movements (e.g. fall-related movements) in their daily living. Geriatr Gerontol Int 2015; ●●: ●●-●●.
### Instruction: Does abdominal compression during endoscopy ( the Bolster technique ) demonstrate hidden Schatzki rings ( with videos )? ### Response:
The Bolster technique is a simple maneuver that can increase detection rates of Schatzki rings during endoscopy.
### Instruction: Does the pathogenic activity of anti-desmoglein autoantibodies parallel disease severity in rituximab-treated patients with pemphigus vulgaris? ### Response:
Our findings have demonstrated the existence of non-pathogenic autoantibodies in PV patients in remission, establishing the basis for the design of a system able to precisely monitor the course of disease.
### Instruction: Is elevated preoperative plasma D-dimer level a useful predictor of chemoresistance and poor disease outcome for serous ovarian cancer patients? ### Response:
Elevated preoperative plasma D-dimer levels were associated with chemoresistance and poor disease outcome in serous ovarian cancer patients. Further validation of this easily available parameter as a promising prognostic biomarker for patients with SOC in prospective studies should be encouraged.
### Instruction: Is preoperative Helicobacter pylori Infection Associated with Increased Survival After Resection of Gastric Adenocarcinoma? ### Response:
Patients with and without preoperative H. pylori infection had few differences in adverse pathologic features at the time of gastric adenocarcinoma resection. Despite similar disease presentations, preoperative H. pylori infection was independently associated with improved OS. Further studies examining the interaction between H. pylori and tumor immunology and genetics are merited.
### Instruction: Is plasma cholesterol related to menstrual status in adolescent girls with eating disorders and weight loss? ### Response:
Increased plasma total cholesterol was related to amenorrhoea in adolescent girls with eating disorders and weight loss. Oestrogens appeared to mediate the effect of starvation on cholesterol, most effectively in premenarcheal girls. Re-establishing menstruation is an important goal in the treatment of eating disorders, to avoid dyslipidaemia and the risk of future cardiovascular disease.
### Instruction: Does evodiamine inhibit the migration and invasion of nasopharyngeal carcinoma cells in vitro via repressing MMP-2 expression? ### Response:
These findings demonstrate that evodiamine inhibits the migration and invasiveness of NPC cells, and it is probably a potential agent for the treatment of NPC invasion and metastasis.
### Instruction: Is [ Low expression of SLC22A1 associated with a poor prognosis of hepatocellular carcinoma : analysis of 303 patients ]? ### Response:
Down-regulation of SLC22A1 is a malignant feature and a potential prognostic marker of HCC.
### Instruction: Do patients With Isolated PCL Injuries Improve From Surgery as Much as Patients With ACL Injuries After 2 Years? ### Response:
Patients undergoing PCL reconstruction can expect the same improvements in KOOS score as patients undergoing ACL reconstruction. However, PCL patients start out with an inferior score on average and consequently end up at a lower score compared with ACL patients for all KOOS subscales.
### Instruction: Does [ Indirubin inhibit the proliferation of prostate cancer PC-3 cells ]? ### Response:
Indirubin can suppress the proliferation of androgen-independent prostate cancer PC-3 cells, which may be associated with its inhibitory effect on the cell cycle and Wnt signaling pathway.
### Instruction: Does [ Intracytoplasmic sperm injection improve the clinical outcomes of the males with 100 % teratozoospermia ]? ### Response:
ICSI cannot improve the clinical outcomes of the male patients with 100% teratozoospermia.
### Instruction: Does triheptanoin dramatically reduce paroxysmal motor disorder in patients with GLUT1 deficiency? ### Response:
Treatment with triheptanoin resulted in a 90% clinical improvement in non-epileptic paroxysmal manifestations and a normalised brain bioenergetics profile in patients with GLUT1-DS.
### Instruction: Are hepatic myofibroblasts derived from Schistosoma mansoni-infected mice a source of IL-5 and eotaxin : controls of eosinophil populations in vitro? ### Response:
These results indicate that GR-MF may contribute to maintenance of local eosinophilia in schistosomal hepatic granulomas, and can function as immunoregulatory cells, besides their role in production of fibrosis.
### Instruction: Does [ Single-tube Single-run Multiplex PCR detect Mixed Samples with Four Species of Plasmodium ]? ### Response:
FP-PCR is a simple and sensitive method for detecting both single-species and mixed infections with human Plasmodium, and can be applied for malaria diagnosis, screening and monitoring.
### Instruction: Does apparent diffusion coefficient measurement covering complete tumor area better predict rectal cancer response to neoadjuvant chemoradiotherapy? ### Response:
The type of measurement technique significantly affected ADC results. ADC measurements covering a larger area better predicted tumor response to therapy. Post-CRT ADCs, regardless of the measurement technique, and numeric ADC change measured in the whole tumor volume accurately identified non-complete responders. Post-CRT ADCs measured in the entire tumor area yielded the highest accuracy level in tumor response evaluation.
### Instruction: Does a new Agkistrodon halys venom-purified protein C activator prevent myocardial fibrosis in diabetic rats? ### Response:
Our results indicate that PCA has anti-fibrotic effects and that it may be used to treat myocardial fibrosis.
### Instruction: Is real-time two-dimensional shear wave ultrasound elastography of the liver a reliable predictor of clinical outcomes and the presence of esophageal varices in patients with compensated liver cirrhosis? ### Response:
This is the first evaluation of RT-2D-SWE as a prognostic tool in LC. Although preliminary and gathered in a limited sample, our data emphasize the potential of LS to be a reliable predictor of clinical outcomes and the presence of EV in LC patients.
### Instruction: Does porcine liver vascular bed in Biodur E20 corrosion cast? ### Response:
Only Biodur E20®Plus appeared to be suitable for high-volume vascular corrosion casting due to its optimal permeability, sufficient processing time and minimum fragility. Biodur E20® Plus is slightly elastic, radio-opaque and alcohol-resistant. These properties make this acrylic resin suitable for not only vascular research but also teaching purposes.
### Instruction: Are pregnancy-associated plasma protein a levels decreased in obstetric cholestasis? ### Response:
In this study, the first trimester PAPP-A levels in the obstetric cholestasis cases were found to be significantly lower than the control group. Low PAPP-A levels should be a warning for obstetric cholestasis.
### Instruction: Is atrophy of type I and II muscle fibers reversible in the case of grade > 2 fatty degeneration of the supraspinatus muscle : an experimental study in rabbits? ### Response:
Atrophy of type I and II muscle fibers in rabbit supraspinatus muscle, characterized by grade >2 fatty degeneration according to the Goutallier computed tomography classification, is reversible after 24 weeks from reattachment of its tendon. A requirement for type I and II muscle fibers hypertrophy is a change in the biomechanical and functional conditions of the muscle after its tendon is reconstructed.
### Instruction: Does pax6 influence expression patterns of genes involved in neuro- degeneration? ### Response:
Presence of BDNF and TGFβ indicates association between them in glioblastoma-astrocytoma. Therefore, Pax6 seems to be involved directly with p53 and TGFβ mediated pathways and indirectly with redox-sensitive pathway regulation. The neurodegenerative markers S100β, GFAP, BDNF, NGN2, p73α, p73δ, observed downregulated in Pax6 knockdown condition suggest Pax6-mediated regulation of these markers. Observations enlighten Pax6-mediated influences on cascades of genes involved in growth, differentiation and maturation of neurons and glia.
### Instruction: Is androgen receptor status highly conserved during tumor progression of breast cancer? ### Response:
Most primary (87 %) and metastasized (86.1 %) BCs are AR positive including a significant fraction of TNBCs (11.4 %). Further, AR status is highly conserved during tumor progression and a change only occurs in a small fraction (4.1 %). Our study supports the notion that targeting AR could be effective for many BC patients and that re-testing of AR status in formerly negative or mixed type BC's is recommended.
### Instruction: Do delays in Referral and Enrolment Are Associated With Mitigated Benefits of Cardiac Rehabilitation After Coronary Artery Bypass Surgery? ### Response:
Strategies for timely access to CR at each phase of the process are important given the negative impact that wait time has on key clinical outcomes. This is relevant because optimizing VO2peak and attendance to CR has been shown to confer a mortality advantage.
### Instruction: Are neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Predictors of Heart Failure? ### Response:
NLR and PLR were higher in HF patients than in age-sex matched controls. However, NLR and PLR were not sufficient to establish a diagnosis of HF. NLR can be used to predict mortality during the follow-up of HF patients.
### Instruction: Are tIMP1 , TIMP2 , and TIMP4 increased in aqueous humor from primary open angle glaucoma patients? ### Response:
An imbalance among MMPs and TIMPs was found in glaucomatous aqueous humor samples, with a shift toward raised TIMP levels. This may result in the inhibition of MMP activity, leading to an altered ECM composition in the TM and thereby contributing to increased outflow resistance.
### Instruction: Does kCC2 expression supersede NKCC1 in mature fiber cells in mouse and rabbit lenses? ### Response:
NKCC1 in peripheral elongating fiber cells is superseded by KCC2 expression in interior mature fiber cells that also express >20 additional integral GABA biology genes, AMPA/NMDA glutamate receptors, and an array of accessory proteins that together underlie morphogenesis in neurons. The present findings provide further evidence that this fundamental neuronal regulation is extensively conserved in lens and identify additional parallels in the morphogenetic programs that underlie lens fiber cell and neuronal differentiation and contribute to the development of visual acuity.
### Instruction: Are hCV viral load at baseline and at week 4 of telaprevir/boceprevir based triple therapies associated with virological outcome in HIV/hepatitis C co-infected patients? ### Response:
Overall SVR12 was 63% and our results suggest that HIV/HCV coinfected patients with low HCV viral load (<800,000 IU/mL) and undetectable HCV-RNA after 4 weeks of triple therapy with TVR or BOC-based regimen have a higher probability of treatment success.
### Instruction: Are the natural fenhexamid-resistant grey mould populations from strawberry in Zhejiang Province dominated by Botrytis cinerea group S? ### Response:
B. cinerea group S isolates are widespread in all strawberry-growing locations in Zhejiang Province. The natural HydR populations from strawberry are dominated by B. cinerea group S. © 2015 Society of Chemical Industry.
### Instruction: Is a 7666-bp genomic deletion frequent in Chinese Han deaf patients with non-syndromic enlarged vestibular aqueduct but without bi-allelic SLC26A4 mutations? ### Response:
Our results suggested that the cryptic c.-2071_307+3801del7666 deletion of SLC26A4 is relatively frequent in Chinese Han non-syndromic EVA patients without bi-allelic SLC26A4 mutations. Screening of this genomic deletion should be incorporated into the routine DNA testing of SLC26A4 in Chinese Hans.
### Instruction: Is cognitive and language performance in children associated with maternal social anxiety disorder : A study of young mothers in southern Brazil? ### Response:
Our findings suggest that children with mothers suffering from SAD have poorer cognitive abilities and language skills.
### Instruction: Are polymorphisms of dopamine pathway genes NRG1 and LMX1A associated with cognitive performance in bipolar disorder? ### Response:
The risk variants of the rs35753505 SNP were associated with increased performance in several cognitive domains and IQ, whereas the risk variants of the rs11809911 SNP in LMX1A was associated with reduced IQ and memory/learning.
### Instruction: Does comparison of Xenorhabdus bovienii bacterial strain genomes reveal diversity in symbiotic functions? ### Response:
The analyses presented here demonstrate that while general mechanisms by which X. bovienii bacterial strains interact with their invertebrate hosts are similar, the specific molecules mediating these interactions differ. Our data support that adaptation of individual bacterial strains to distinct hosts or niches has occurred. For example, diverse metabolic profiles among bacterial symbionts may have been selected by dissimilarities in nutritional requirements of their different nematode hosts. Similarly, factors involved in parasitism (e.g. immune suppression and microbial competition factors), likely differ based on evolution in response to naturally encountered organisms, such as insect hosts, competitors, predators or pathogens. This study provides insight into effectors of a symbiotic lifestyle, and also highlights that when mining Xenorhabdus species for novel natural products, including antibiotics and insecticidal toxins, analysis of multiple bacterial strains likely will increase the potential for the discovery of novel molecules.
### Instruction: Is the relationship between insomnia with short sleep duration associated with hypercholesterolemia : a cross-sectional study? ### Response:
Insomnia with short sleep duration was associated with increased odds of hypercholesterolemia. Caregivers in clinical practice should watch out for the effect brought by this novel factor.
### Instruction: Does radiographic Stage Correlate With Symptom Severity in Thumb Basilar Joint Osteoarthritis? ### Response:
Radiographic severity in TBJA does not correlate with validated patient-reported symptom scores. Metrics that link radiographic and subjective components of TBJA may improve surgical decision making and monitoring of treatment response.
### Instruction: Is anal cushion lifting method a novel radical management strategy for hemorrhoids that does not involve excision or cause postoperative anal complications? ### Response:
We consider that the ACL method might be better than all other current methods for managing hemorrhoids.
### Instruction: Do feelings of worthlessness during a single complicated major depressive episode predict postremission suicide attempt? ### Response:
Among depressive symptoms during an MDE, feelings of worthlessness is the only significant indicator of elevated risk of suicide attempt after the episode has remitted, beyond previous suicide attempts.
### Instruction: Is tumor invasion depth a useful pathologic assessment for predicting outcomes in cervical squamous cell carcinoma after neoadjuvant radiotherapy? ### Response:
The TID or TIDC measured at the cervical internal surface is a useful and easily applied pathologic prognostic factor for distant metastasis and survival outcomes in patients with cervical squamous cell carcinoma treated with neoadjuvant RT or CCRT.
### Instruction: Does endoscopic Mediastinal Staging in Lung Cancer be Superior to `` Gold Standard '' Surgical Staging? ### Response:
Combined EBUS- and EUS-guided biopsies can access more targets, including lung and distant metastasis, and thus have the potential to upstage patients compared with mediastinoscopy and change the treatment plan.
### Instruction: Is colonoscopy performance stable during the course of an extended three-session working day? ### Response:
Colonoscopy quality does not appear to depend on time of day or queue position in an extended three-session day.
### Instruction: Does carbapenem Resistance in Non-Fermentative Bacterial Species and in Enterobacteriaceae isolate from Hospitalized Patients in Different Health-Care Settings? ### Response:
Our study demonstrates that infections with carbapenem-resistant strains are correlated with hospitalization in intensive care units. Our data showed a predominant carbapenem-resistant Acinetobacter spp. strain in intensive care units.
### Instruction: Is quality of Life in Thyroid Cancer Similar to That of Other Cancers with Worse Survival? ### Response:
We found the self-reported QOL of thyroid cancer survivors in our study population is overall similar to or worse than that of survivors of other types of cancer surveyed with the same instrument. This should heighten awareness of the significance of a thyroid cancer diagnosis and highlights the need for further research in how to improve care for this enlarging group of patients.
### Instruction: Does motor Function be Associated With Incident Disability in Older African Americans? ### Response:
Better motor function in older African Americans is associated with a decreased risk of developing disability. Moreover, the association of motor function and disability is stronger in individuals with better cognitive function.
### Instruction: Does dietary Protein Intake be Protective Against Loss of Grip Strength Among Older Adults in the Framingham Offspring Cohort? ### Response:
Higher dietary intakes of total and animal protein were protective against loss of grip strength in community-dwelling adults aged 60 years and older. Increasing intake of protein from these sources may help maintain muscle strength and support prevention of mobility impairment in older adults.
### Instruction: Is carotid stiffness associated with incident stroke : a systematic review and individual participant data meta-analysis? ### Response:
Carotid stiffness is associated with incident stroke independently of CV factors and aortic stiffness. In addition, carotid stiffness improves stroke risk prediction beyond Framingham and aortic stiffness.
### Instruction: Does partial-Volume Effect Correction improve Quantitative Analysis of 18F-Florbetaben β-Amyloid PET Scans? ### Response:
The influence of PVEC on (18)F-florbetaben PET data is associated with the degree of brain atrophy. Thus, PVEC increases the ability of (18)F-florbetaben PET to discriminate between AD patients and HCs, to detect Aβ plaques in the atrophic mesial temporal cortex, and potentially to evaluate changes in brain Aβ load over time. As such, the use of PVEC should be considered for quantitative (18)F-florbetaben PET scans, especially in assessing patients with brain atrophy.
### Instruction: Is prolonged Operative Time to Extubation a Useful Metric for Comparing the Performance of Individual Anesthesia Providers? ### Response:
Bayesian methodology with covariate adjustment is better suited to performance monitoring than an unadjusted, nonhierarchical frequentist approach because it is less likely to identify individuals spuriously as outliers. Targeting outliers in an effort to alter operating room activities is unlikely to have an operational impact (although monitoring may serve other purposes). If change is deemed necessary, it must be made by improving the average behavior of everyone and by focusing on anesthesia providers rather than on faculty.
### Instruction: Are tNNT2 Gene Polymorphisms Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in Kazak and Han Chinese? ### Response:
The TNNT2 polymorphisms might play an important role in susceptibility to DCM in Xinjiang Kazak and Han patients.
### Instruction: Does complementary Serologic Investigations in Children with Celiac Disease be Unnecessary during Follow-Up? ### Response:
Complementary blood investigations are relevant at the time of diagnosis of CD but have little diagnostic yield during follow-up visits once the patient is placed on a gluten-free diet. Thus, we recommend that these variables only be assessed on indication, such as fatigue or abnormal growth.
### Instruction: Does laboratory and dialysis characteristics in hemodialysis patients suffering from chronic itch -- result from a representative cross-sectional study? ### Response:
Long-term follow-up studies will show if the type of dialysis membrane influences the development of CI in HD patients. It is most likely that several factors e.g. elevated parathormone, origin of end stage renal disease (ESRD), type of dialysis membrane, and a neuropathic component all contribute to the occurrence of CI in HD patients. Future research should consider a multifactorial origin of itch in HD.
### Instruction: Does proteomics of the red blood cell carbonylome during blood banking of erythrocyte concentrate? ### Response:
Affected cellular mechanisms involve antioxidant defenses, metabolism pathways, and proteasomal degradation. To better store RBCs those functions have to be preserved, which opens new routes of investigation in transfusion medicine.
### Instruction: Does insulin combined with Chinese medicine improve glycemic outcome through multiple pathways in patients with type 2 diabetes mellitus? ### Response:
The results from our study showed that the combination therapy of SQF and insulin significantly improved the clinical outcome of type 2 diabetes mellitus compared with insulin monotherapy. The mechanism of improvement was possibly involved in the multiple pathways.
### Instruction: Is carbohydrate intake associated with time spent in the euglycemic range in patients with type 1 diabetes? ### Response:
Carbohydrate intake is associated with time spent in euglycemia in patients with type 1 diabetes.
### Instruction: Is metabolic Syndrome Associated with Increased Postoperative Morbidity and Hospital Resource Utilization in Patients Undergoing Elective Pancreatectomy? ### Response:
MS is an under-emphasized predictor of increased postoperative morbidity and utilization of hospital resources in patients undergoing elective pancreatectomy. The effect of MS on these postoperative outcomes appears to be more pronounced for patients with benign rather than malignant indications for pancreatectomy and in patients undergoing distal rather than proximal pancreatectomy. These results may inform patient selection, optimization of comorbidities prior to elective pancreatectomy, and strategies for postoperative management.
### Instruction: Do [ The preliminary study of the origin characters of snore in simple snorers ]? ### Response:
The palatal fluttering is the main source of snoring sounds for most simple snorers, then followed by vibration of palatal and pharyngeal lateral wall together. The site of collapse in pharyngeal cavity is consistent with the main site of vibration.
### Instruction: Does mATERNAL AND POST-WEANING EXPOSURE TO A HIGH FAT DIET promote VISCERAL OBESITY AND HEPATIC STEATOSIS IN ADULT RATS? ### Response:
the food intake did not differ among the groups, however, the relative weight of the adipose tissue was higher in animals from the HC, HH and CH groups (p ≤ 0.005). Liver steatosis was found in the CH and HH animals, which also exhibited hypercholesterolemia (p ≤ 0.05). The levels of the liver enzymes alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (GGT) were higher in the HH group, and the LDL level was higher in the CH group compared to the CC. The consumption of an obesogenic diet during critical periods of development may contribute to the occurrence of visceral obesity, liver steatosis and hypercholesterolemia in adult rats, even in the absence of changes in dietary intake.
### Instruction: Does vagus Nerve Stimulation During Rehabilitative Training improve Forelimb Recovery After Chronic Ischemic Stroke in Rats? ### Response:
VNS paired with rehabilitative training confers significantly greater recovery of forelimb function after chronic ischemic stroke in rats.
### Instruction: Is reorganization of Azospirillum brasilense cell membrane mediated by lipid composition adjustment to maintain optimal fluidity during water deficit? ### Response:
Azospirillum brasilense is able to perceive osmotic changes by changing the membrane fluidity. This effect is offset by changes in the composition of membrane phospholipid and FA, contributing to the homeostasis of membrane fluidity under water deficit.
### Instruction: Is obesity associated with greater inflammation and monocyte activation among HIV-infected adults receiving antiretroviral therapy? ### Response:
Obesity was prevalent and independently associated with greater monocyte activation and systemic inflammation. Research is needed to determine how adipose tissue excess is functionally related to persistent immunologic abnormalities among HIV-infected persons with viral suppression.
### Instruction: Does dickkopf1 Up-Regulation Induced by a High Concentration of Dexamethasone promote Rat Tendon Stem Cells to Differentiate Into Adipocytes? ### Response:
In conclusion, by upregulating DKK1 expression, reducing the level of P-GSK-3β (ser9), and increasing the level of P-GSK-3β (tyr216), Dex causes the degradation of β-catenin, the central molecule of the classical WNT pathway, thereby inducing rat TSCs to differentiate into adipocytes.
### Instruction: Is autophagy , which decreased in labouring fetal membranes , regulates IL-1β production via the inflammasome? ### Response:
Autophagy is decreased in fetal membranes after spontaneous labour and delivery, and PPROM. Inhibition of autophagy regulates the secretion of IL-1β via inflammasome activation. IL-1β is a major contributor to the pathophysiology of spontaneous preterm birth. Therefore activation of autophagy may be a potential therapeutic mechanism to delay or prevent infection-induced preterm birth.
### Instruction: Do protocol for a systematic review of quantitative burn wound microbiology in the management of burns patients? ### Response:
Given the increasing use of quantitative methods, this is a timely systematic review, which will attempt to clarify the evidence base. As far as the authors are aware, it will be the first to address this topic.
### Instruction: Are longer durations of antitumour necrosis factor treatment associated with reduced risk of cardiovascular events in patients with rheumatoid arthritis? ### Response:
Anti-TNF therapy was associated with a significantly lower risk of cardiovascular events among patients with RA, older patients with RA and patients without prior exposure to methotrexate.
### Instruction: Do serum interferon-inducible protein 10 levels predict hepatitis B s antigen seroclearance in patients with chronic hepatitis B? ### Response:
Lower serum IP-10 level at Year 0 was the only factor associated with HBsAg seroclearance.
### Instruction: Does single oral dose of maraviroc prevent ex-vivo HIV infection of rectal mucosa in HIV-1 negative human volunteers? ### Response:
An ex-vivo challenge with a single oral dose of MVC does not prevent ex-vivo infection of human rectal mucosa. The lack of prophylactic efficacy observed suggests that 'on demand' MVC preexposure prophylaxis would not prevent rectal HIV-1 transmission.
### Instruction: Are high levels of serum mannose-binding lectins associated with the severity and clinical outcomes of severe traumatic brain injury? ### Response:
Increased serum level of MBL was independently associated with head trauma severity and long-term clinical outcomes of STBI.
### Instruction: Is functional dyspepsia associated with GNβ3 C825T and CCK-AR T/C polymorphism? ### Response:
TT genotype of GNβ3 C825T is more common among patients with FD than among HC, suggesting that increased signal transduction associated with this genotype may be important in its pathophysiology. However, CCK-AR polymorphism is protective against FD.
### Instruction: Is a high-fat diet associated with otitis media with effusion? ### Response:
A high-fat diet was associated with OME and may represent a confounding factor between obesity and OME.
### Instruction: Do large deletions play a minor but essential role in congenital coagulation factor VII and X deficiencies? ### Response:
Large deletions play a minor but essential role in the mutational spectrum of the F7 and F10 genes. Copy number analyses (e. g. MLPA) should be considered if sequencing cannot clarify the underlying reason of an observed coagulopathy. Of note, in cases of combined FVII/FX deficiency, a deletion of the two contiguous genes might be part of a larger chromosomal rearrangement.
### Instruction: Does reconstruction of the Posterolateral Corner After Sequential Sectioning restore Knee Kinematics? ### Response:
The PFL has a key role between 30° and 90° of flexion, and the lateral collateral ligament plays a role in extension. Reconstruction with the modified Larson technique restores these 2 complementary stabilizers of the knee.
### Instruction: Is a Fixed Flow More Effective than Titrated Flow during Bubble Nasal CPAP for Respiratory Distress in Preterm Neonates? ### Response:
In preterm infants on bubble CPAP with set pressures of 4-6 cm H2O, a fixed flow of 5 L/min is more effective than a flow titrated to ensure adequate visible bubbling. It achieves higher delivered pressures, better oxygenation and ventilation.
### Instruction: Does [ Crypotanshione reduce the expression of metadherin in DU145 prostate cancer cells ]? ### Response:
CPT can inhibit the proliferation and induce the apoptosis of DU145 prostate cancer cells, which may be associated with its suppression of the downstream PI3K/AKT signaling pathway by reducing the expression of metadherin in the DU145 cells.
### Instruction: Does microRNA367 negatively regulate the inflammatory response of microglia by targeting IRAK4 in intracerebral hemorrhage? ### Response:
In conclusion, our study demonstrates that miR-367/IRAK4 pathway plays an important role in microglial activation and neuroinflammation in ICH. Our finding also suggests that miR-367 might represent a potential therapeutic target for ICH.
### Instruction: Is percutaneous biliary drainage oncologically inferior to endoscopic drainage : a propensity score matching analysis in resectable distal cholangiocarcinoma? ### Response:
Compared with EBD, PTBD increases the incidence of seeding metastasis after resection for distal cholangiocarcinoma and shortens postoperative survival.
### Instruction: Does risk factors for severe injury following indoor and outdoor fall in geriatric patients? ### Response:
Transport to the ED by public ambulance or from another medical facility, and head and neck injury were risks for severe injury following indoor and outdoor falls in elderly subjects. Efforts to identify the risk factors for severe injury and for falling itself are important to prevent and reduce fall injuries in elderly subjects.
### Instruction: Is visual impairment , but not hearing impairment , independently associated with lower subjective well-being among individuals over 95 years of age : A population-based study? ### Response:
Visual impairment, but not hearing impairment, was independently associated with low SWB among LLIs, and functional ability may play a mediating role in the observed relationship. The findings indicate that rehabilitation targeted for those with reduced vision and functioning in long-lived populations may be important for promoting well-being and quality of life.
### Instruction: Are adolescent Intermittent Alcohol Exposure : Dysregulation of Thrombospondins and Synapse Formation Associated with Decreased Neuronal Density in the Adult Hippocampus? ### Response:
Repeated EtOH exposure during adolescence results in long-term changes in specific astrocyte signaling proteins and their neuronal synaptogenic receptor. Continued signaling by these traditionally developmental factors in adulthood may represent a compensatory mechanism whereby astrocytes reopen the synaptogenic window and repair lost connectivity, and consequently contribute to the enduring maladaptive structural and functional abnormalities previously observed in the hippocampus after AIE.
### Instruction: Is obstructive sleep apnea with excessive daytime sleepiness associated with non-alcoholic fatty liver disease regardless of visceral fat? ### Response:
In the present study, OSA was closely associated with NAFLD in Korean adults. This association was particularly strong in those with EDS or short sleep duration regardless of VFA.
### Instruction: Does tobacco Use be Associated With Increased Complications After Anterior Cruciate Ligament Reconstruction? ### Response:
ACL reconstruction in patients who use tobacco is associated with significantly increased rates of infection, VTE, and subsequent ACL reconstruction compared with controls. There was no association between tobacco use and postoperative arthrofibrosis after primary ACL reconstruction.
### Instruction: Do chemostat culture systems support diverse bacteriophage communities from human feces? ### Response:
Because the diversity of phages in these cultured fecal communities have similarities to those found in humans, we believe these communities can serve as valuable ecosystems to help uncover the role of phages in human microbial communities.
### Instruction: Does mammalian prion protein ( PrP ) form conformationally different amyloid intracellular aggregates in bacteria? ### Response:
Overall, our results suggest that modelling PrP amyloid formation in microbial cell factories might open an avenue for a better understanding of the structural features modulating the pathogenic impact of this intriguing protein.
### Instruction: Does the BCL11A-XL expression predict relapse in squamous cell carcinoma and large cell carcinoma? ### Response:
Our results demonstrated that the BCL11A-XL isoform might be a potential prognostic biomarker of SCC and LCC.
### Instruction: Does analysis of pulmonary function test result in a health check-up population? ### Response:
Health check-up is an important approach for screening COPD, obstructive ventilator dysfunction, and obstructive small airway disease. Smoking cessation and controlling of relevant risk factors are helpful to lower the incidences of these conditions.
### Instruction: Does notochord manipulation impact oesophageal and tracheal formation from isolated foregut in 3D explant culture? ### Response:
The relationship between the embryonic foregut and notochord is complex and ill-defined; however, the notochord does not contribute essentially to oesophagus and trachea formation beyond E9 in the mouse, and the transplantation of additional notochord does not disrupt foregut separation in 3D explant culture.
### Instruction: Does down-regulation of microRNA-155 attenuate retinal neovascularization via the PI3K/Akt pathway? ### Response:
The results revealed that the downregulation of miR-155 attenuated retinal neovascularization via the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.
### Instruction: Does allergic Lung Inflammation aggravate Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice? ### Response:
This study suggests a pathological link between airway allergic disease and AAA. Production of one disease aggravates the progression of the other.
### Instruction: Does adjuvant Stereotactic Radiosurgery reduce Need for Retreatments in Patients with Meningioma Residuals? ### Response:
aSRS of meningioma residuals had a positive effect on tumor control and should be considered in patients with meningioma residuals.
### Instruction: Does intrinsic Visual-Motor Synchrony correlate With Social Deficits in Autism? ### Response:
Our twice replicated findings confirm that visual-motor functional connectivity is disrupted in ASD. Furthermore, the observed temporal incongruity between visual and motor systems, which may reflect diminished integration of visual consequences with motor output, was predictive of the severity of social deficits and may contribute to impaired social-communicative skill development in children with ASD.
### Instruction: Is elevated plasma aldosterone an independent risk factor for erectile dysfunction in men? ### Response:
We determined that elevated plasma aldosterone concentration is an independent risk factor for ED. Our findings also indicate that the aldosterone, a well-recognized contributor to vascular injury, might be a potential bond between ED and CVD.
### Instruction: Is arterial Vasoreactivity Equally Affected by In Vivo Cross-Clamping with Increasing Loads in Young and Middle-Aged Mice Aortas? ### Response:
Within the tested conditions, mechanical clamping induces damage to the vascular endothelium, but not to the smooth muscle cells. Age has no effect on the obtained results in mice from 10 to 40 weeks old.
### Instruction: Does bCL3 reduce the Sterile Inflammatory Response in Pancreatic and Biliary Tissues? ### Response:
BCL3 is up-regulated in inflamed pancreatic or biliary tissues from mice and patients with AP or cholangitis. Its production appears to reduce the inflammatory response in these tissues via blocking ubiquitination and proteasome-mediated degradation of p50 homodimers.
### Instruction: Is regular Chinese Green Tea Consumption Protective for Diabetic Retinopathy : A Clinic-Based Case-Control Study? ### Response:
Diabetic patients who had regularly drunk Chinese green tea every week for at least one year in their lives had a DR risk reduction of about 50% compared with those who had not. Regular Chinese green tea consumption may be a novel approach for the prevention of DR.
### Instruction: Do peak oxygen uptake during the incremental shuttle walk test in a predominantly female population with Chagas heart disease? ### Response:
This study showed the good correlation between distance walked in ISWT and VO2 peak directly measured in both tests, and additionally, provided an equation to calculate a predictive VO2 peak by ISWT, suggesting a good alternative to evaluate the FC of CHD patients, especially in locations where sophisticated testing is not available.
### Instruction: Is in ICU state anxiety associated with posttraumatic stress symptoms over six months after ICU discharge : A prospective study? ### Response:
Posttraumatic stress symptoms occurred in a significant proportion of ICU survivors and were significantly associated with higher levels of trait anxiety, younger age, mental health treatment prior to the ICU admission and more symptoms of anxiety after ICU discharge. Early assessment and interventions directed to reduce state and trait anxiety in ICU survivors may be of benefit.
### Instruction: Does dense genotyping of immune-related loci identify HLA variants associated with increased risk of collagenous colitis? ### Response:
HLA genotype associates with CC, thus implicating HLA-related immune mechanisms in its pathogenesis.
### Instruction: Are methotrexate-loaded lipid-core nanocapsules highly effective in the control of inflammation in synovial cells and a chronic arthritis model? ### Response:
The MTX-LNC were better than the MTX solution at reducing proinflammatory cytokines and T-cell-derived cytokines such as interferon-gamma and interleukin-17A. This result, combined with the reduction in the dose required for therapy, shows that MTX-LNC are a very promising system for the treatment of RA.
### Instruction: Does sepsis impair microvascular autoregulation and delays capillary response within hypoxic capillaries? ### Response:
Sepsis impaired microvascular autoregulation at both the individual capillary and erythrocyte level, seemingly uncoupling the RBC acting as an "O2 sensor" from microvascular autoregulation. Impaired microvascular autoregulation was manifested by increased capillary stopped-flow, increased capillary response time within hypoxic capillaries, decreased capillary O2 supply rate and decreased RBC O2-dependent ATP efflux. This loss of local microvascular control was partially off-set by increased capillary RBC supply rate, which correlated with increased plasma NOx.
### Instruction: Does acute disruption of glucagon secretion or action improve glucose tolerance in an insulin-deficient mouse model of diabetes? ### Response:
Disruption of glucagon action/secretion did not improve glucose tolerance in diabetic mice. Near-total alpha cell elimination may have prevented further deterioration. Our findings support insulin lack as the major factor underlying hyperglycaemia in beta cell-deficient diabetes.
### Instruction: Does intracarotid Etomidate decrease the Interhemispheric Synchronization in Electroencephalogram ( EEG ) During the Wada Test? ### Response:
Our study showed that the EEG effects of intracarotid ipsilateral injection of etomidate is not uniform in both hemispheres. Decrease in the interhemispheric synchronization of delta waves might serve as an indicator of ipsilateral effect of etomidate on the brain. Additional studies are needed to confirm our findings.