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### Instruction: Does constitutive secretion of Interleukin-4 dictate CD133+ side population cells to resist drug treatment and cell death? ### Response:
Our data suggest that the autocrine secretion of IL-4 is a potential target for the development of novel anticancer drugs to prevent the CSCs-mediated therapy failure and tumorigenesis.
### Instruction: Does prescription consisting of Vitamin C and Baicalin inhibit tumor growth by enhancing the antioxidant capacity in vivo? ### Response:
PVB shows better antitumor effect than Vc and baicalin used alone, and it can significantly enhance the immunity and antioxidant capacity of the mice.
### Instruction: Is total laparoscopic resection for advanced gastric cancer safe and feasible in the Western population? ### Response:
Following total laparoscopic resection for advanced gastric cancer, oncologic endpoints, postoperative course, and early cancer-specific follow-up are excellent. The results demonstrated here support the routine use of these techniques in the Western patient population.
### Instruction: Does p38 MAPK mediate glial P2X7R-neuronal P2Y1R inhibitory control of P2X3R expression in dorsal root ganglion neurons? ### Response:
p38 in DRG neurons downstream of P2Y1R is necessary and sufficient for the P2X7R-P2Y1R inhibitory control of P2X3R expression.
### Instruction: Do tECPR2 mutations cause a new subtype of familial dysautonomia like hereditary sensory autonomic neuropathy with intellectual disability? ### Response:
We suggest that the disease should therefore be classified as a new subtype of hereditary sensory-autonomic neuropathy. The discovery of additional mutations in non-Bukharian patients implies that this disease might be more common than previously appreciated and should therefore be considered in undiagnosed cases of intellectual disability with autonomic features and respiratory symptoms regardless of demographic origin.
### Instruction: Are early term infants at increased risk of requiring neonatal intensive care? ### Response:
Being born at early term is associated with increased risk of respiratory disease and hypoglycemia requiring neonatal intensive care. Further efforts directed at decreasing early term deliveries may be warranted.
### Instruction: Does opioid Prescribing at Hospital Discharge contribute to Chronic Opioid Use? ### Response:
Opioid receipt at hospital discharge among opioid naïve patients increased future chronic opioid use. Physicians should inform patients of this risk prior to prescribing opioids at discharge.
### Instruction: Is abdominal radiography necessary in children with intussusception? ### Response:
AR is not recommended for the diagnosis of intussusception in children, for the prediction of the outcome of PRI or for the detection of occult pneumoperitoneum. AR should always be performed when clinical peritonism is present but is not otherwise necessary in children with suspected or confirmed intussusception.
### Instruction: Are symptoms of Depression Common in Patients With Idiopathic Normal Pressure Hydrocephalus : The INPH-CRasH Study? ### Response:
Symptoms of depression are overrepresented in INPH patients compared with the population, despite treatment with a shunt. Screening for depression should be done in the evaluation of INPH patients in order to find and treat a coexisting depression.
### Instruction: Do background differences in baseline and stimulated MMP levels influence abdominal aortic aneurysm susceptibility? ### Response:
These data demonstrate that 129/SvEv mice are more susceptible to AAA compared to C57Bl/6 mice. Intrinsic properties of the aorta between the two strains of mice, including baseline expression of MMP-2, influence susceptibility to AAA.
### Instruction: Does uptake of Marasmius oreades agglutinin disrupt integrin-dependent cell adhesion? ### Response:
Our results suggest a possible toxic mechanism of MOA, which consists of disturbing the cell adhesion and the cell viability.
### Instruction: Does cD73 predict Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer? ### Response:
High CD73 immunoreactivity was associated with favorable clinicopathological features. Furthermore, it predicts better outcome in the subgroup of pTa and pT1 tumors and may thus serve as additional tool for the selection of patients with favorable prognosis.
### Instruction: Does high-pressure physiological saline isotonic solution administration enhance brain NGF and NGF-receptors expression? ### Response:
It was found that forced administration of HpPSIS enhances the presence of these neurotrophic signals, not only in the olfactory bulbs, but also in forebrain cholinergic neurons, which are known to degenerate as result of memory loss and brain aging, including Alzheimer Disease. These findings for the first time in the literature demonstrate the possibility of enhancing the endogenous NGF to protect NGF-damaged neurons. Since the enhanced expression of NGF was first observed after 5 days of treatment and higher after 10 days of treatment, a reasonable hypothesis is that longer HpPSIS treatment might further enhance the level of NGF in brain and olfactory bulbs.
### Instruction: Does mechanical fibrinogen-depletion support heparin-free mesenchymal stem cell propagation in human platelet lysate? ### Response:
Here, we present an efficient, reproducible and economical method in compliance to good manufacturing practice for the preparation of MSC media avoiding xenogenic components and suitable for clinical studies.
### Instruction: Is painful knee but not hand osteoarthritis an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women? ### Response:
We found a significantly increased risk of all-cause and CVD-specific mortality in women experiencing knee pain with or without ROA but not ROA alone. No relationship was found between hand OA and mortality risk. This suggests that knee pain, more than structural changes of OA is the main driver of excess mortality in patients with OA.
### Instruction: Does alternaria induce Production of Thymic Stromal Lymphopoietin in Nasal Fibroblasts Through Toll-like Receptor 2? ### Response:
The results of this study show that TSLP expression could be induced in nasal fibroblasts by exposure to Alternaria and that TLR2 may be involved in the process. The promotion of TSLP production in nasal fibroblasts by airborne fungi may facilitate the development or exacerbation of Th2-type nasal inflammation, especially in CRS with nasal polyps.
### Instruction: Is the Interaction Between Prenatal Exposure to Home Renovation and Reactive Oxygen Species Genes in Cord Blood IgE Response Modified by Maternal Atopy? ### Response:
Maternal atopy modified the effect of prenatal exposure to home renovation on CB serum IgE response as well as the interaction between the exposure and neonatal genes involved in the oxidative stress pathway. These findings suggest that the genetically susceptible offspring of atopic mothers may be more vulnerable to the effect of prenatal exposure to home renovation on the development of allergy.
### Instruction: Does neural Reactivity to Emotional Stimuli Prospectively predict the Impact of a Natural Disaster on Psychiatric Symptoms in Children? ### Response:
Results indicate that heightened neural reactivity and attention toward unpleasant information, as measured by the LPP, predispose children to psychiatric symptoms when exposed to higher levels of stress related to natural disasters, while greater reactivity to and processing of pleasant information may be a protective factor.
### Instruction: Does hydrogen Sulfide alleviate Peritoneal Fibrosis via Attenuating Inflammation and TGF-β1 Synthesis? ### Response:
Exogenous H2S ameliorates the pathologic process of peritonitis via attenuating inflammatory events and TGF-β1 synthesis. These results suggest that H2S may be a potential therapy against peritoneal fibrosis during chronic PD. In the future, compounds releasing H2S at controlled rate will be assessed as potential candidates to treat peritoneal fibrosis.
### Instruction: Does [ Programmed death ligand 1 negatively regulate inflammatory response of chronic periodontitis ]? ### Response:
The expression of PD-L1 in the periodontal tissue negativelv regulates inflammatory periodontal tissue damage.
### Instruction: Does executive Functioning predict Academic But Not Social Adjustment to University? ### Response:
The BASC-College form may identify depression symptoms predictive of social adjustment, but symptoms of inattention or hyperactivity are not sufficiently sensitive to predict academic adjustment. Measures of executive function that include metacognition such as the BRIEF-A may be most promising in identifying skills predictive of academic adjustment.
### Instruction: Is rotator Cuff Weakness a Risk Factor for First-Time Anterior Glenohumeral Instability? ### Response:
No association was found between isometric shoulder strength measures at baseline and subsequent first-time anterior glenohumeral joint instability within the high-risk athletic population studied in this prospective cohort.
### Instruction: Does andrographolide attenuate LPS-Induced Cardiac Malfunctions Through Inhibition of IκB Phosphorylation and Apoptosis in Mice? ### Response:
And prevents LPS-induced cardiac malfunctions in mice by inhibiting TNF-α, IL-1β, and NO production, IκB phosphorylation, and cardiac apoptosis, indicating that And may be a potential agent for preventing myocardial malfunction during sepsis.
### Instruction: Do hematoxylin and eosin stain shows a high sensitivity but sub-optimal specificity in demonstrating iron pigment in liver biopsies? ### Response:
We demonstrate that the H and E stain is a sensitive method to detect iron pigment in liver biopsies, particularly when present in large quantities. A negative H and E stain might obviate the need for extra Perls' staining, thus saving costs and shortening report turn-around times.
### Instruction: Is aIP1 a novel Agenet/Tudor domain protein from Arabidopsis that interacts with regulators of DNA replication , transcription and chromatin remodeling? ### Response:
AIP1 is a novel Agenet/Tudor domain protein in plants that could act as a link between DNA replication, transcription and chromatin remodeling during flower development.
### Instruction: Does a Naturally Occurring rev1-vpu Fusion Gene Confer a Fitness Advantage to HIV-1? ### Response:
Expression of a rev1-vpu fusion gene does not affect regular Rev and Vpu functions or alter HIV-1 replication in primary target cells. Since there is no evidence for increased replication fitness of rev1-vpu encoding viruses, this polymorphism likely emerged in the context of other mutations within and/or outside the rev1-vpu intergenic region, and may have a neutral phenotype.
### Instruction: Does multiple Intercostal Space Electrocardiogram allow Accurate Localization of Outflow Tract Ventricular Arrhythmia Origin? ### Response:
The combined TZ index outperformed other ECG criteria to differentiate left from right OT-VA origins.
### Instruction: Does exenatide facilitate Recovery from Oxaliplatin-Induced Peripheral Neuropathy in Rats? ### Response:
These results suggest that exenatide may be useful for treating peripheral neuropathy induced by oxaliplatin in colorectal cancer patients with type 2 diabetes.
### Instruction: Are high homocysteine , low vitamin B-6 , and increased oxidative stress independently associated with the risk of chronic kidney disease? ### Response:
High homocysteine, low PLP, increased oxidative stress, and decreased antioxidant enzyme activity (superoxide dismutase activity) were independent contributing factors in the development of early stage CKD.
### Instruction: Does dNA Methylation of MMP9 be Associated with High Levels of MMP-9 Messenger RNA in Periapical Inflammatory Lesions? ### Response:
The present study suggests that the unmethylated status of the MMP9 gene in periapical lesions may explain the observed up-regulation of messenger RNA transcription in these lesions.
### Instruction: Does miR-132 inhibit lung cancer cell migration and invasion by targeting SOX4? ### Response:
Our finding provides new insight into the mechanism of NSCLC progression. Therapeutically, miR-132 may serve as a potential target in the treatment of human lung cancer.
### Instruction: Is miR-1290 a potential prognostic biomarker in non-small cell lung cancer? ### Response:
Our study suggests that miR-1290 is overexpressed in NSCLC, and serum miR-1290 may be used as a potential prognostic biomarker for NSCLC.
### Instruction: Are functional polymorphisms in the gene encoding macrophage migration inhibitory factor ( MIF ) associated with active pulmonary tuberculosis? ### Response:
These data suggested a distinct genetic and immunopathogenic basis for tuberculosis at the MIF locus. Serum MIF, IFN-γ and TNF-α profiles distinguish tuberculosis from the more inflammatory phenotype and may play a role in pathogenesis and as biomarkers of active tuberculosis.
### Instruction: Does autophagy contribute to the chemo-resistance of non-small cell lung cancer in hypoxic conditions? ### Response:
Autophagy may play an important role in acquiring resistance to chemotherapy in lung cancer and hypoxia related pathway seems to be involved in autophagy induction.
### Instruction: Do mapping areas of spatial-temporal overlap from wildlife tracking data? ### Response:
The value of the jPPA approach within current wildlife habitat analysis workflows is highlighted along with its simple and straightforward implementation and interpretation. Given the current emphasis on remote tracking in wildlife movement and habitat research, new approaches capable of leveraging both the spatial and temporal information content contained within these data are warranted. We make code (in the statistical software R) for implementing the jPPA approach openly available for other researchers.
### Instruction: Are serum caspase-3 levels and mortality associated in patients with severe traumatic brain injury? ### Response:
The association between serum caspase-3 levels and mortality in TBI patients was the major novel finding of our study.
### Instruction: Are iCMJE authorship criteria met in a substantial proportion of manuscripts submitted to Biochemia Medica? ### Response:
Large proportion of authors of the manuscripts submitted to Biochemia Medica do not fulfil ICMJE criteria. Violation of authorship criteria is not more common for manuscripts with some type of scientific misconduct.
### Instruction: Do divergent growth strategies between red algae and kelps influence biomechanical properties? ### Response:
We propose that divergent patterns in the distribution of material properties along blades may have different consequences for the performance of kelps and red algae. The positioning of younger tissues at the blade base for kelps may enable these species to attain larger body sizes in wave-swept habitats.
### Instruction: Is lower-normal TSH associated with better metabolic risk factors : A cross-sectional study on Spanish men? ### Response:
TSH and free T4 within the normal range are associated with the metabolic syndrome. The sample half-below the TSH median (with probably higher functional thyroid status) exhibited better metabolic and cardiovascular profiles.
### Instruction: Does poor self-rated health predict mortality in patients with stable chronic heart failure? ### Response:
Poor self-rated health predicts mortality in our long-term follow-up of patients with stable chronic heart failure, even after adjustment for established risk predictors. We encourage clinicians to capture patient-reported self-rated health routinely as an easy to assess, clinically meaningful measure and pay extra attention when self-rated health is poor.
### Instruction: Does disordered eating behavior and mental health correlate among treatment seeking obese women? ### Response:
Findings corroborate earlier work indicating that psychological distress is elevated in obese treatment seeking, bolstering the need for mental health assessment of such individuals. The feeling of ineffectiveness constitutes the major predictor of psychopathological aspects. This is an important result which may inform the development of effective interventions for obese patients and prevention of psychopathological disorders.
### Instruction: Is a male preponderance in patients with Indian post kala-azar dermal leishmaniasis associated with increased circulating levels of testosterone? ### Response:
Taken together, our study has established a male dominance in PKDL, which showed a strong association with testosterone. This information should be taken into consideration for disease monitoring and control.
### Instruction: Does ankaferd blood stopper enhance healing after osseous grafting in patients with intrabony periodontal defects? ### Response:
The findings suggest that ABS enhances the soft tissue healing during the periodontal defect fill by the ACB by stimulating angiogenesis and vascular endothelial cell function, prevents GR and thereby increases the clinical attachment gain.
### Instruction: Does transamniotic stem cell therapy ( TRASCET ) mitigate bowel damage in a model of gastroschisis? ### Response:
Amniotic mesenchymal stem cells mitigate bowel damage in experimental gastroschisis after concentrated intraamniotic injection. Transamniotic stem cell therapy (TRASCET) may become a practical component of the treatment of gastroschisis.
### Instruction: Does treatment of subclinical hypothyroidism affect bone mass as determined by dual-energy X-ray absorptiometry , peripheral quantitative computed tomography and quantitative bone ultrasound in Spanish women? ### Response:
Our results indicate that adequate metabolic control through replacement treatment with L-T4 in pre- and postmenopausal women does not affect bone mass.
### Instruction: Is co-morbid personality disorder in early intervention psychosis clients associated with greater key worker emotional involvement? ### Response:
Co-morbid PD is common in EIPS patients. The EIPS model is both assertive and intensive; although this appears to be effective in preventing hospital admissions, this does not equip professionals to manage the higher emotional burden associated with a co-morbid PD diagnosis.
### Instruction: Is cDX2 downregulation associated with poor differentiation and MMR deficiency in colon cancer? ### Response:
We found that CDX2 downregulation is associated with MMR deficiency, right-sided tumors, and poor differentiation at both the mRNA and protein level. Whether CDX2 plays an active role in tumor progression in MSI/MMR-deficient tumors remains to be elucidated.
### Instruction: Does fibroblast growth factor 8 regulate postnatal development of paraventricular nucleus neuroendocrine cells? ### Response:
First, Fgf8 hypomorphy did not eliminate VP and CRH neurons in the mouse PVN, but rather disrupted the postnatal timing of neuropeptide expression onset in PVN neurons. Second, Fgf8 hypomorphy may, in part, be an explanation for affective disorders involving hyperactivity of the HPA axis, such as anxiety.
### Instruction: Do inferior vena cava diameters and collapsibility index reveal early volume depletion in a blood donor model? ### Response:
IVC diameter and collapsibility index variations, as measured in M mode, consistently detect volume changes after blood donation. The longitudinal mid-hepatic approach performed better by allowing a panoramic view, avoiding anatomical aberrancies at fixed points and permitting to identify the best possible perpendicular plane to the IVC. In addition, it was able to detect time-dependent physiological volume replacement. In contrast, in our hands, the renal window could not be visualized consistently well.
### Instruction: Does targeting protein arginine methyltransferase 5 inhibit human hepatocellular carcinoma growth via the downregulation of beta-catenin? ### Response:
PRMT5 plays an important role in HCC. PRMT5 may be a promising target for HCC therapy.
### Instruction: Does trinitrotoluene induce Endoplasmic Reticulum Stress and Apoptosis in HePG2 Cells? ### Response:
TNT could increase the expression levels of GRP78, GRP94, Caspase-4, and CHOP in HePG2 cells; this increase in protein expression might be involved in HePG2 apoptosis through the induction of the ERS pathway.
### Instruction: Does interleukin-17A be Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome? ### Response:
Elevated circulating and alveolar levels of interleukin-17A are associated with increased percentage of alveolar neutrophils, alveolar permeability, and organ dysfunction in acute respiratory distress syndrome.
### Instruction: Does resveratrol relieve gestational diabetes mellitus in mice through activating AMPK? ### Response:
Our findings further supported the potential therapeutic effect of RV on not only diabetes, but also alleviating GDM.
### Instruction: Does rush immunotherapy for wasp venom allergy seem safe and effective in patients with mastocytosis? ### Response:
VIT is safe in cutaneous mastocytosis patients with WA, while caution has to be made in case of systemic mastocytosis. VIT was effective in the patients who were re-stung.
### Instruction: Does low-Level Vagus Nerve Stimulation attenuate Myocardial Ischemic Reperfusion Injury by Antioxidative Stress and Antiapoptosis Reactions in Canines? ### Response:
LL-VNS exerts protective effects on myocardial I/R injury. Its potential mechanisms involve the suppression of oxidative stress and cellular apoptosis.
### Instruction: Is bone marrow involvement rare in superficial gastric mucosa-associated lymphoid tissue lymphoma? ### Response:
Bone marrow involvement was rare in patients with only superficial gastric MALT lymphoma without extragastric invasion. Further studies are warranted to identify the risk factors of bone marrow involvement in gastric MALT lymphoma.
### Instruction: Does next-Generation Sequencing of Matched Primary and Metastatic Rectal Adenocarcinomas demonstrate Minimal Mutation Gain and Concordance to Colonic Adenocarcinomas? ### Response:
-The somatic mutations identified in our rectal adenocarcinoma cohort showed a strong correlation to those previously characterized in colonic adenocarcinoma. In addition, most rectal adenocarcinomas harbored identical somatic mutations in both the primary tumor and metastasis. These findings demonstrate evidence that rectal adenocarcinoma follows a similar molecular pathogenesis as colonic adenocarcinoma and that sampling either the primary or metastatic lesion is valid for initial evaluation of somatic mutations and selection of possible targeted therapy.
### Instruction: Does new probing and warm-wash-out technique improve early patency rates in arteriovenous fistula surgery? ### Response:
Probing and warm-wash out technique will simply increase the surgical success and flow rate of draining vein.
### Instruction: Are dNA methylation subgroups in melanoma associated with proliferative and immunological processes? ### Response:
Melanoma consists of divergent methylation groups that are distinguished by promoter methylation, proliferation and content of immunological cells.
### Instruction: Does horizontal Slide create Less Cervical Motion When Centering an Injured Patient on a Spine Board? ### Response:
Of the three adjustments, our team found that horizontal slide was also easier to complete than the other methods. The horizontal slide best limited cervical spine motion and may be the most helpful for minimizing secondary injury based on the study findings.
### Instruction: Is serum dipeptidyl peptidase-4 associated with multiple vertebral fractures in type 2 diabetes mellitus? ### Response:
We firstly showed that high level of serum DPP-4 is associated with prevalent multiple VFs independently of BMD and bone formation in men with T2DM.
### Instruction: Are gender differences in scalp hair growth rates maintained but reduced in pattern hair loss compared to controls? ### Response:
Caucasian ethnicity.
### Instruction: Does neuromuscular Blocking Agent Cisatracurium attenuate Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1? ### Response:
The use of NMBA is lung protective through its antiinflammatory properties by blocking the nAChRα1.
### Instruction: Does bone morphogenetic protein 7 sensitize O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide? ### Response:
These data support the view that reduced endogenous BMP7 expression/signaling in GSC may contribute to maintained stemness, EMT, and chemoresistant phenotype, suggesting that BMP7 treatment may provide a novel strategy in combination with TMZ for an effective treatment of glioblastoma exhibiting unmethylated MGMT.
### Instruction: Is p21 deficiency susceptible to osteoarthritis through STAT3 phosphorylation? ### Response:
The lack of p21 has catabolic effects by regulation of aggrecan and MMP-13 expression through STAT3 phosphorylation in the cartilage tissue. p21 may function as a regulator of transcriptional factors other than the inhibitor of cell cycle progression in the cartilage tissue. Thus, the regulation of p21 may be a therapeutic strategy for the treatment of OA.
### Instruction: Does herbal compound Naoshuantong capsule attenuate retinal injury in ischemia/reperfusion rat model by inhibiting apoptosis? ### Response:
Our study indicated that Naoshuantong capsule attenuates retinal damage in rat models of ischemic ophthalmopathy, possibly by inhibiting apoptosis.
### Instruction: Does tLE6 mutation cause the earliest known human embryonic lethality? ### Response:
In this first report of a human defect in a member of the subcortical maternal subcritical maternal complex, we show that the TLE6 mutation is gender-specific and leads to the earliest known human embryonic lethality phenotype.
### Instruction: Does atrial electrogram interpretation improve after an innovative education program? ### Response:
Accurate interpretation of AEGs is an easy skill for specialized critical care nurses to learn via an online education program.
### Instruction: Does cFTR potentiator therapy ameliorate impaired insulin secretion in CF patients with a gating mutation? ### Response:
The treatment with ivacaftor in patients with CF carrying gating mutation can ameliorate impaired insulin secretion. Further studies and larger cohorts are needed to evaluate the impact of ivacaftor on insulin secretion in patients with CF carrying gating or other mutations.
### Instruction: Does [ Methylglyoxal inhibit human umbilical vein cell migration in vitro by down-regulating integrinβ3 ]? ### Response:
Methylglyoxal inhibits HUVEC migration in vitro by down-regulating integrin β3 expression.
### Instruction: Is cYP2C9 Genetic Polymorphism a Potential Predictive Marker for the Efficacy of Rosuvastatin Therapy? ### Response:
This study suggests that the CYP2C9 polymorphism may be involved in the lipid-lowering efficacy of rosuvastatin in patients with hyperlipidemia.
### Instruction: Is downregulation of MicroRNA-1 Associated with Poor Prognosis in Hepatocellular Carcinoma? ### Response:
Low miR-1 expression is associated with shortened survival time. MiR-1 may act as a potential prognostic biomarker for HCC patients.
### Instruction: Do cold snare piecemeal resection of colonic and duodenal polyps ≥1 cm? ### Response:
Cold snare polypectomy for large duodenal and colonic polyps is technically feasible and may have a favorable safety profile compared to standard electrocautery-based endoscopic resection. Comparative trials are required to determine the relative safety and efficacy of cold snare techniques for complete and durable resection of large polyps compared to standard hot snare methods.
### Instruction: Do [ What do the doctors of different specialties know about sleep disorders and their treatment ]? ### Response:
Physicians are not well informed about the problems of sleep disorders, have a small idea of the methods of sleepresearch and drugs for their treatment as well as of a sequence of operations that should be used to resolve this problem.
### Instruction: Is visceral adiposity associated with altered myocardial glucose uptake measured by ( 18 ) FDG-PET in 346 subjects with normal glucose tolerance , prediabetes , and type 2 diabetes? ### Response:
Our findings indicate visceral adiposity is strongly associated with the alteration of myocardial glucose uptake evaluated by (18)FDG-PET, and its association further relates to T2DM.
### Instruction: Do aqueous extracts of Fructus Ligustri Lucide induce gastric carcinoma cell apoptosis and G2/M cycle arrest? ### Response:
These results confirmed that FLL could induce apoptosis in human gastric carcinoma, the underlying molecular mechanisms, at least partially, through activation p21/p53 and suppression CDC2/cdc25C signaling in vitro.
### Instruction: Is proactive Semantic Interference Associated with Total and Regional Abnormal Amyloid Load in Non-Demented Community-Dwelling Elders : A Preliminary Study? ### Response:
In non-demented individuals, vulnerability to PSI was highly associated with total and regional beta-amyloid load and may be an early cognitive marker of brain pathology.
### Instruction: Do experimental evaluation of sand fly collection and storage methods for the isolation and molecular detection of Phlebotomus-borne viruses? ### Response:
While the collection and storage methods investigated had not much impact on the ability to detect viral RNA by molecular methods, they affected the capacity to recover viable viruses. Consequently, sand fly collection and handling procedures should be established in advance depending on the goal of the surveillance studies.
### Instruction: Does high glucose induce renal tubular epithelial injury via Sirt1/NF-kappaB/microR-29/Keap1 signal pathway? ### Response:
High glucose induces renal tubular epithelial injury via Sirt1/NF-κB/microR-29/Keap1 signal pathway.
### Instruction: Is horizontal gene transfer in bdelloid rotifers ancient , ongoing and more frequent in species from desiccating habitats? ### Response:
Nearly half of foreign genes were acquired before the divergence of bdelloid families over 60 Mya. Nonetheless, HGT is ongoing in bdelloids and has contributed to putative functional differences among species. Variation among our study species is consistent with the hypothesis that desiccating habitats promote HGT.
### Instruction: Does low-Dose Docetaxel Combined with Dexamethasone be Feasible for Patients with Castration-Resistant Prostate Cancer? ### Response:
Low-dose docetaxel in combination with dexamethasone is feasible in Japanese CRPC patients. Hematological toxicity is less than that seen with standard docetaxel therapy, but it is necessary to monitor patients for severe nonhematological toxicities, particularly very elderly patients.
### Instruction: Does the profile of platelet α-granule released molecules affect postoperative liver regeneration? ### Response:
The postoperative profile of circulating platelet-derived factors correlates with the ability of the remnant liver to regenerate. Portal venous pressure and intrahepatic endothelial dysfunction might account for the selective granule release profile. Selective modulation of platelet α-granule release in patients may represent an attractive target for therapeutic interventions to improve liver regeneration and clinical outcomes after partial hepatectomy.
### Instruction: Do large-volume low apparent diffusion coefficient lesions predict poor survival in bevacizumab-treated glioblastoma patients? ### Response:
The volume of low-ADC lesions at the second post-bevacizumab scan predicted shorter OS. This suggests that low-ADC lesions may be considered important imaging markers and included in treatment decision algorithms.
### Instruction: Are glut-1 intensity and pattern of expression in thymic epithelial tumors predictive of WHO subtypes? ### Response:
Glut-1 expression globally depended on histological subtypes and the staining patterns (diffuse or zonal) were different between thymic carcinomas and type B3 thymomas. A comparative study of Glut-1 expression in atypical versus conventional type A thymomas appears warranted. Otherwise, restriction to epithelial cells makes likely a correlation with clinical assessment of glucose uptake in lymphocyte-poor tumors.
### Instruction: Does eIF2A-dependent translational arrest protect leukemia cells from the energetic stress induced by NAMPT inhibition? ### Response:
We identified EIF2A phosphorylation as a novel early molecular event occurring in response to NAMPT inhibition and mediating protein synthesis arrest. In addition, our data suggest that tumors exhibiting an impaired LBK1- AMPK- EIF2A response may be especially susceptible to NAMPT inhibitors and thus become an elective indication for this type of agents.
### Instruction: Does evaluation of anxiety levels and factors associated with positive test result in patients with drug hypersensitivity? ### Response:
Patients with DHR have high levels of anxiety; however, this is not related to the results of drug tests. Because panic reaction symptoms may accompany the objective symptoms of DHR, a complete clinical work-up is required before deciding whether the reaction is related to panic or a "true DHR."
### Instruction: Do validation of Duruöz Hand Index in patients with tetraplegia? ### Response:
The DHI was found a valid method in the assessment of hand functions in patients with tetraplegia.
### Instruction: Does diazoxide protect L6 skeletal myoblasts from H2O2-induced apoptosis via the phosphatidylinositol-3 kinase/Akt pathway? ### Response:
These data suggest that DZ pre-treatment contributes to protection of L6 SKMs against apoptosis at least partly by activating the PI3K/Akt pathway and subsequently inhibiting the mitochondrial-mediated caspase-dependent apoptotic signalling pathway.
### Instruction: Is dopamine Administration a Risk Factor for Delirium in Patients Undergoing Coronary Artery Bypass Surgery? ### Response:
Along with older age, dopamine infusion--even in low doses but more probably in higher doses--emerged as an independent risk factor for delirium in patients undergoing CABG. Further study is needed to confirm the validity of results presented.
### Instruction: Does novel PPARγ Modulator GED-0507-34 Levo ameliorate Inflammation-driven Intestinal Fibrosis? ### Response:
GED ameliorates intestinal fibrosis in dextran sulfate sodium-induced chronic colitis in mice and regulates major profibrotic cellular and molecular mechanisms.
### Instruction: Does flightless I Homolog repress Prostate Cancer Progression through Targeting Androgen Receptor Signaling? ### Response:
FLII plays a tumor-suppressive role and serves as a crucial determinant of resistance of prostate cancer to endocrine therapies.
### Instruction: Does a 13 mer LNA-i-miR-221 Inhibitor restore Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells? ### Response:
Taken together, our findings provide the proof of concept that LNA-i-miR-221 can reverse melphalan resistance in preclinical models of multiple myeloma, providing the framework for clinical trials to overcome drug resistance, and improve patient outcome in multiple myeloma.
### Instruction: Are cXCL4 Plasma Levels Associated with the Extent of Coronary Artery Disease or with Coronary Plaque Morphology? ### Response:
While CXCL4 may be present and active within the arterial wall, local increase of CXCL4 may not translate into systemically elevated CXCL4 levels. Further studies will have to test whether CXCL4 may still represent a suitable therapeutic target in human atherosclerosis.
### Instruction: Does micronutrient Deficiency Independently predict Adverse Health Outcomes in Patients With Heart Failure? ### Response:
These findings show that micronutrient deficiency independently predicted poor HRQoL and earlier cardiac event-free survival in patients with HF. Further research is needed to provide for specific dietary guidelines for better health outcomes in HF patients.
### Instruction: Does axillary Lymph Node Dissection be a Risk Factor for Major Complications After Immediate Breast Reconstruction? ### Response:
Mastectomy with ALND is associated with a 3-fold increase in risk of major complications in women undergoing immediate breast reconstruction, even after adjustment for known risk factors and confounders. Further studies are warranted to elucidate how ALND leads to these complications and what measures can reduce their occurrence.
### Instruction: Does sT depression in lead aVL differentiate inferior ST-elevation myocardial infarction from pericarditis? ### Response:
When there is inferior ST-segment elevation, the presence of any ST depression in lead aVL is highly sensitive for coronary occlusion in inferior myocardial infarction and very specific for differentiating inferior myocardial infarction from pericarditis.
### Instruction: Does occult H. pylori infection partially explain 'false-positive ' results of ( 13 ) C-urea breath test? ### Response:
UBiT suffers from a high rate of false-positive results and sub-optimal specificity, and the protocol skipping citric acid pre-treatment should be revised; however, low-density 'occult' H. pylori infection that was undetectable by conventional tests accounted for around 25% of the 'false-positive' results.
### Instruction: Does co-Transplantation of Skin-Derived Precursors and Collagen Sponge facilitate Diabetic Wound Healing by Promoting Local Vascular Regeneration? ### Response:
Accelerated wound healing and enhanced local capillary regeneration could be observed 14 days after skin ablation from both SKPs and collagen sponge co-transplanted and collagen sponge only groups. Subsequent analyses further revealed superior pro-angiogenic effects from the SKP and collagen sponge co-delivered group, which are mainly attributable to in vivo transdifferentation and paracrine signalling of the SKPs.
### Instruction: Do a Profilometric Study to Assess the Role of Toothbrush and Toothpaste in Abrasion Process? ### Response:
Besides supporting the fact that toothpaste is needed to create a significant abrasion, this study also showed that a softer toothbrush can cause more abrasion than harder ones. The flexibility of bristles is only secondary to abrasion process and abrasivity of dentifrice has an important role in abrasion process.
### Instruction: Are anxiety but not depression symptoms associated with greater perceived dyspnea in asthma during bronchoconstriction? ### Response:
Anxiety but not depression was associated with greater perceived dyspnea intensity but not other measures of respiratory discomfort in individuals with asthma. Anxiety may shape the quality and intensity of dyspnea at a given respiratory load.