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### Instruction: Does register based monitoring show decreasing socioeconomic differences in Finnish perinatal health? ### Response:
Social inequality in perinatal health outcomes exists in Finland, but seems to have diminished in the 1990s. These data showed that routinely collected birth register data provide a good source for studies on socioeconomic health differences in the perinatal period, but that uncertainty, mainly attributable to the large group of women with difficult to classify socioeconomic status, remains.
### Instruction: Does hospital attendance prediction tool also identify impaired quality of life in adults with asthma in general practice? ### Response:
An RSQ score predictive of hospital attendance should alert the general practitioner to explore and address symptom, activity, and impact domains associated with impaired quality of life in adult asthma.
### Instruction: Does monomeric immunoglobulin E stabilize FcepsilonRIalpha from the human basophil cell line KU812 by protecting it from natural turnover? ### Response:
These results indicate that IgE does not induce intracellular signals in KU812, i.e., tyrosine-phosphorylation or Ca2+ release. Instead it appears that FcepsilonRIalpha is an unstable protein that IgE stabilizes and thereby protects from a temperature dependent turnover.
### Instruction: Is coronary endothelial dysfunction associated with an increased risk of cerebrovascular events? ### Response:
Presence of CED in patients without obstructive CAD is independently associated with an increased risk of cerebrovascular events. Thus, detection of this early stage of atherosclerosis may provide important information to identify patients who benefit from aggressive preventive strategies.
### Instruction: Is amyloid-beta found in drusen from some age-related macular degeneration retinas , but not in drusen from normal retinas? ### Response:
Abeta was present in 4 of 9 AMD eyes. Within these eyes, Abeta localized to a subset of drusen. None of the 9 normal eyes surveyed, some of which had small drusen, were A beta positive. Abetapositive vesicles were most numerous in GA eyes at the edges of atrophy, the region at risk for further degeneration. These results suggest that Abeta in drusen correlates with the location of degenerating photoreceptors and retinal pigment epithelium (RPE) cells. Further work will be necessary to determine whether Abeta deposition in drusen may contribute to or result from retinal degeneration.
### Instruction: Does four weeks of androstenedione supplementation diminish the treatment response in middle aged men? ### Response:
Although supplementation with 200 mg/day androstenedione increases AUC for serum androstenedione in the day 0 condition, continued supplementation is characterised by a diminished treatment response, coupled with time 0 increases in testosterone precursors but not testosterone.
### Instruction: Do the effects of ocular and lens parameters on the postlens tear thickness? ### Response:
These results show that the base curve radius of a soft contact lens and several ocular characteristics can affect the thickness of the postlens tear film.
### Instruction: Are elevated plasma fibrinogen levels in patients with essential hypertension related to vascular complications? ### Response:
Hyperfibrinogenemia is a marker of vascular damage and could be an important factor contributing to the evolution of the complications.
### Instruction: Do simple anatomical measurements correlate significantly to individual peripheral nerve stimulation thresholds as measured in MRI gradient coils? ### Response:
These results suggest it is unlikely that a simple physiologic measurement of subject anatomy can be used to guide the operation of MRI scanners in a subject-specific manner in order to increase gradient system performance while avoiding PNS.
### Instruction: Does itraconazole pulse therapy improve the quality of life of patients with toenail onychomycosis? ### Response:
Itraconazole pulse therapy is an effective treatment and can improve the QOL of patients with toenail onychomycosis.
### Instruction: Does amifostine reduce the toxicity of the fludarabine and cyclophosphamide regimen in patients with chronic lymphocytic leukemia? ### Response:
The study amifostine regimen did not reduce the toxicity or activity of the FC regimen in patients with CLL.
### Instruction: Is the activity of camptothecin analogues enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH? ### Response:
Evaluation of anticancer drug activity in native-state histoculture supports the concept that pH modulation may be an important approach to improve the selectivity and antitumor effectiveness of camptothecin-based chemotherapy.
### Instruction: Is long-term outcome of acute myocarditis independent of cardiac enzyme release? ### Response:
After acute myocarditis, there is late recovery of left ventricular ejection fraction, which is independent of the initial myocardial damage measured by cardiac enzyme release.
### Instruction: Does cyclooxygenase-2-dependent superoxide generation contribute to age-dependent impairment of G protein-mediated cerebrovasodilation? ### Response:
These data show that G protein activation elicits cerebrovasodilation that is blunted following FPI in an age-dependent manner, and suggest that cyclooxygenase-2-dependent superoxide anion generation contributes to G protein activation-induced dilator impairment after the insult in an age-dependent manner.
### Instruction: Does n-acetylcysteine restore isoflurane-induced preconditioning against myocardial infarction during hyperglycemia? ### Response:
Acute hyperglycemia abolishes reductions in myocardial infarct size produced by isoflurane, but N-acetylcysteine restores these beneficial effects. The results suggest that excessive quantities of reactive oxygen species generated during hyperglycemia impair isoflurane-induced preconditioning in dogs.
### Instruction: Does temporal summation govern part of the minimum alveolar concentration of isoflurane anesthesia? ### Response:
Increasing the duration or frequency (interstimulus interval) of stimulation increases the concentration of isoflurane required to suppress movement by a 0.4 minimum alveolar concentration MK801 blocks this effect, a finding consistent with temporal summation (which requires intact N-methyl-D-aspartate receptor activity) at concentrations of up to 1 minimum alveolar concentration isoflurane.
### Instruction: Does ectopic expression of the beta-cell specific transcription factor Pdx1 inhibit glucagon gene transcription? ### Response:
Cell-specific expression of the glucagon gene can only occur when Pdx1 expression extinguishes from the early alpha cell precursor.
### Instruction: Does high dose of caffeine administered to pregnant rats cause histopathological changes in the cornea of newborn pups? ### Response:
Excessive gestational caffeine intake has been shown histopathologically to have some teratogenic effects on newborn rat cornea.
### Instruction: Does simvastatin reduce infarct size in a model of acute myocardial ischemia and reperfusion in the rat? ### Response:
The result indicates that simvastatin, an inhibitor of HMG-CoA reductase and a ligand of PPAR-a and PPAR-g, reduces the tissue necrosis associated with acute myocardial infarction. We propose that statins may be useful in conditions associated with ischemia-reperfusion of the heart and other organs.
### Instruction: Do low doses of diagnostic energy X-rays protect against neoplastic transformation in vitro? ### Response:
Low doses (< 1 cGy) of 60 kVp X-rays protect HeLa x skin fibroblast human hybrid cells against neoplastic transformation in vitro.
### Instruction: Is operant responding for a visual reinforcer in rats enhanced by noncontingent nicotine : implications for nicotine self-administration and reinforcement? ### Response:
Nicotine influences operant behavior in two ways: by acting as a primary reinforcer when it is contingent upon behavior, and by directly potentiating the reinforcing properties of other stimuli through a nonassociative mechanism. Nicotine self-administration and smoking may be largely dependent upon this later action.
### Instruction: Does depression influence the EDI scores in anorexia nervosa patients? ### Response:
The present results suggested that the EDI scores are clearly influenced by the severity of depression. Among the psychopathological and behavioural traits assessed with the EDI, only a few were not related to depressive symptoms: "feeling of inefficiency" and "distrust in interpersonal relations".
### Instruction: Do endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis? ### Response:
EC release qualitatively and quantitatively distinct EMP during activation compared to apoptosis. Analysis of EMP phenotypic signatures may provide clinically useful information on the status of the endothelium.
### Instruction: Do neuroblastoma cells inhibit the immunostimulatory function of dendritic cells? ### Response:
These findings have significant implications for tumor-pulsed DC vaccines in the treatment of NB and suggest a mechanism by which NB escape rejection.
### Instruction: Does advanced neuroblastoma impair dendritic cell function in adoptive immunotherapy? ### Response:
IL-12 DC from tumor-bearing animals have a decreased ability to induce antitumor activity against established murine NB. This decreased capacity appears to be related to the duration of exposure to tumor because day 14 transduced DC had less of an effect than day 7 DC, despite similar phenotypes and ability to activate immune effector cells.
### Instruction: Does eGF receptor signaling affect bcl-2 family gene expression and apoptosis after massive small bowel resection? ### Response:
After massive small bowel resection, inhibition of the EGFR accelerates the rate of apoptosis and modifies the expression of specific bcl-2 family members to favor apoptosis. These results further support a specific mechanistic pathway for the regulation of enterocyte apoptosis after SBR via EGFR signaling.
### Instruction: Is expression of vascular endothelial growth factor D associated with lymph node metastasis in human colorectal carcinoma? ### Response:
These results suggest that the expression of VEGF-D protein could be useful in predicting the nodal status of colorectal carcinoma patients.
### Instruction: Is neonatal interleukin-12 capacity associated with variations in allergen-specific immune responses in the neonatal and postnatal periods? ### Response:
Reduced APC IL-12 production in the perinatal period was associated with reduced T cell activation (lymphoproliferation), stronger neonatal Th2 responses, and weaker Th1 responses to allergen in the postnatal period. This supports the notion that variations in APC function in early life may contribute to altered allergen-specific cytokine responses associated with later allergy.
### Instruction: Does tonography demonstrate reduced facility of outflow of aqueous humor in myocilin mutation carriers? ### Response:
Carriers of the myocilin Thr377Met mutation have reduced outflow facility, which may be detected prior to developing glaucoma. Tonography was not seen to be clinically useful in predicting progression towards glaucoma.
### Instruction: Do serum levels of cytokines correlate to donor chimerism and acute graft-vs.-host disease after haematopoietic stem cell transplantation? ### Response:
These results indicate that an imbalance between pro-inflammatory and immune- modulating cytokines are involved in the development of chimerism and acute GVHD after allo-SCT. The Fas/FasL pathway is probably involved in the elimination of recipient cells leading to full donor chimerism.
### Instruction: Does the dynostatic algorithm accurately calculate alveolar pressure on-line during ventilator treatment in children? ### Response:
Fibreoptic measurement of tracheal pressure in combination with the dynostatic calculation of alveolar pressure provides an on-line monitoring of the effects of ventilatory mode in terms of volume-dependent compliance, tracheal peak pressure and true positive end expiratory pressure.
### Instruction: Do heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia? ### Response:
HSP70-2+1267 genotype is a stronger predictor of septic shock in patients with community-acquired pneumonia than lymphotoxin-alpha +250 genotype.
### Instruction: Does midazolam exhibit characteristics of a highly permeable P-glycoprotein substrate? ### Response:
The results indicate that midazolam exhibited characteristics of a highly permeable P-gp substrate. 1-OH midazolam formation during A-to-B midazolam transport increased slightly when P-gp was inhibited.
### Instruction: Does intraaortic filtration capture particulate debris in OPCAB cases using anastomotic devices? ### Response:
These data clearly suggest that there is no difference between the amount of particulate debris generated in OPCAB cases versus CPB cases. In OPCAB cases where an anastomosis device was used without a partial clamp, particulate debris may be reduced but not eliminated. These findings may demonstrate the importance of aortic manipulation, particularly clamping, as a source of particulate material in cardiac surgery. However, more study needs to be done to confirm these findings with a larger number of patients.
### Instruction: Do endodontic treatment of permanent teeth in children with a new calcium-carbamide-formaldehyde paste? ### Response:
The calcium-carbamide-formaldehyde paste stimulates bone regeneration and closing of the apex without coloring the hard dental tissues.
### Instruction: Do kidneys in hypertensive rats show reduced response to nitric oxide synthase inhibition as evaluated by BOLD MRI? ### Response:
Based on the differential effect of NO synthase inhibition on medullary oxygenation, BOLD MRI can distinguish hypertensive from normal kidney. Our results are consistent with previously reported observations using invasive methods.
### Instruction: Is selective COX-2 inhibition associated with decreased mucosal damage induced by acid and pepsin in rabbit esophagitis? ### Response:
COX-1 activity is constitutive in the rabbit esophageal mucosa, but both COX-2 and COX-1 activity are increased under the impact of acidified pepsin. Treatment with the COX-2 inhibitor DFU is associated with improvement of mucosal damage, which may have therapeutic implications.
### Instruction: Is blood transfusion , independent of shock severity , associated with worse outcome in trauma? ### Response:
Blood transfusion is confirmed as an independent predictor of mortality, ICU admission, ICU LOS, and hospital LOS in trauma after controlling for severity of shock by admission base deficit, lactate, shock index, and anemia. The use of other hemoglobin-based oxygen-carrying resuscitation fluids (such as human or bovine hemoglobin substitutes) in the acute postinjury period warrants further investigation.
### Instruction: Do plasma oxidative parameters and mortality in patients with severe burn injury? ### Response:
For the first time we demonstrate the value of oxidative parameters, namely thiobarbituric acid reactive species, protein carbonyls, and xanthine oxidase activity, in identifying burn patients with a poor prognosis. Whether these parameters are merely markers of clinical course, or whether they signal specific deleterious effects of oxidative stress during the burn injury remains to be elucidated.
### Instruction: Is intima-media thickness of the common carotid artery the significant predictor of angiographically proven coronary artery disease? ### Response:
The increase in IMT is the significant positive predictor of angiographically proven CAD; other predictors are high age, low HDL cholesterol and, less significantly, high total cholesterol. Presence of carotid plaques and male sex do not add any new information for the prediction of CAD once the predictors are considered.
### Instruction: Does alcohol affect executive cognitive functioning differentially on the ascending versus descending limb of the blood alcohol concentration curve? ### Response:
Our results support the conclusion that alcohol negatively affects cognitive performance and has a differential effect on the descending versus the ascending limb of the blood alcohol concentration curve. The latter finding may have important ramifications relating to the detrimental consequences of alcohol intoxication.
### Instruction: Does mecamylamine attenuate the subjective stimulant-like effects of alcohol in social drinkers? ### Response:
These findings suggest that nicotinic cholinergic receptors are involved in mediating some of the stimulant-like effects of alcohol.
### Instruction: Is serotonin transporter gene variation associated with alcohol sensitivity in rhesus macaques exposed to early-life stress? ### Response:
As in some human reports, this study demonstrates a diminution in the response to alcohol in animals homozygous for the l rh5-HTTLPR allele. The phenotypic expression of this genotype in l/s animals, however, is environmentally dependent.
### Instruction: Do serodiagnosis of human plague by a combination of immunomagnetic separation and flow cytometry? ### Response:
Compared with a recently published combination of an anti-F1 CA enzyme-linked immunosorbent assay (ELISA) and immunoblot, the new assay showed the same sensitivity as the ELISA and almost the same specificity (99.0 versus 100%) as the immunoblot. Allowing a rapid, reliable, and quantitative analysis, immunomagnetic separation combined with flow cytometry might replace both conventional immunoassays.
### Instruction: Does brief refeeding rapidly reverse dietary restriction-induced nuclear factor-kappaB downregulation in peritoneal resident cells? ### Response:
The blunted NFkappaB activity in PRCs, after exposure to inflammatory stimuli, was restored after 1 day of refeeding, with increased accumulation of NFkappaB in the cytoplasm. Even brief nutritional replenishment in malnutrition may improve host defense by restoring NFkappaB activity and thereby improving macrophage functions.
### Instruction: Is dexamethasone-associated toxicity during induction chemotherapy for childhood acute lymphoblastic leukemia augmented by concurrent use of daunomycin? ### Response:
The addition of daunomycin led to a much larger increase in dexamethasone-related toxicity compared with the increase in prednisone-related toxicity. Although the use of daunomycin enhanced dexamethasone-related toxicity, this enhancement did not result in a higher mortality rate or the alteration of planned ALL therapy.
### Instruction: Does hepatocyte growth factor stimulate proliferation and migration during wound healing of retinal pigment epithelial cells in vitro? ### Response:
HGF stimulated wound closure in cultured RPE cells, and rendered restituted cells epithelioid in shape. HGF may become a therapeutic candidate for RPE wound healing.
### Instruction: Does chemiluminescence assay improve specificity of hepatitis C antibody detection? ### Response:
CA produces fewer false-positive and fewer low-positive results that require confirmatory RIBA testing. The S/C ratio remains useful for characterizing positive results.
### Instruction: Does [ Lipopolysaccharide enhance DNA binding activity of nuclear factor-kappa B in the mouse cochlea ]? ### Response:
LPS could induce NF-kappa B activation in the cochlea. Moreover, this study implies that tissues from LPS-inoculated cochlea might serve as a useful positive control in the study on activation of NF-kappa B in cochlea.
### Instruction: Does adenosine-activated myocardial ischemia induce delayed preconditioning? ### Response:
Adenosine-induced ischemia does not exert a delayed protective effect in respect to cardiac bioelectrical and mechanical functions in patients with ischemic heart disease in the form of stable effort angina.
### Instruction: Do scirrhous changes in dysplastic nodules indicate high-grade status? ### Response:
This evidence indicated that the scirrhous change in DN was not a specific feature of high-grade DN. We also found that scirrhous DN have two morphological varieties that may represent biologically different processes, that is, pericellular scirrhous type and stellate scirrhous type.
### Instruction: Does gross appearance of hepatocellular carcinoma reflect E-cadherin expression and risk of early recurrence after surgical treatment? ### Response:
Types 2 and 3 HCC have marked metastatic and invasive potential and reduced expression of E-cadherin, predicting a high risk of recurrence after surgical treatment.
### Instruction: Is antenatal pelvic organ mobility associated with delivery mode? ### Response:
Third trimester pelvic organ mobility is associated with duration of second stage and delivery mode.
### Instruction: Does alefacept therapy produce remission for patients with chronic plaque psoriasis? ### Response:
Alefacept is a biological agent for the treatment of chronic plaque psoriasis that provides disease-free intervals and time off drug therapy.
### Instruction: Does impact on survivors of retinoblastoma when informed of study result on risk of second cancers? ### Response:
These findings indicate that research participants want feedback even when the information is upsetting. Additional studies are needed to identify individuals who experience greater levels of distress following feedback in an attempt to provide improved methods of feedback and support.
### Instruction: Does corneal endothelial morphology result in the Menicon Z 30-day continuous-wear contact lens clinical trial? ### Response:
The Menicon Z lens wearers in this study did not show significant endothelial cell morphology changes after 1 year of nearly continuous contact lens wear. This finding is particularly important considering the RGP wearers in this study were older by a average of 10 years (mean age approximately 40) and had worn their contact lenses an average of almost 10 years longer than the soft contact lens wearers.
### Instruction: Is rhinovirus detectable in peripheral lung tissue after asthma death? ### Response:
RV infection of the lower airway may be an uncommon cause of fatal asthma. Alternatively, RV may not extend to peripheral airways and more proximal tissue sampling or PCR assays for other viruses may be required to determine an association between viral respiratory tract infection and fatal asthma.
### Instruction: Is in vitro growth rate of fibroblast-like synovial cells reduced by methotrexate treatment? ### Response:
The results suggest that FLS growth in monolayer is not dependent on the disease affecting the joint. MTX treatment, however, was more relevant in determining FLS growth rate.
### Instruction: Does mycophenolate mofetil prevent a clinical relapse in patients with systemic lupus erythematosus at risk? ### Response:
Administration of MMF after a rise in antibodies to dsDNA is well tolerated, decreases anti-dsDNA and B cell activation, and seems to prevent the occurrence of a clinical relapse in patients with SLE.
### Instruction: Is prothrombin G20210A mutation , but not factor V Leiden , a risk factor in patients with persistent foramen ovale and otherwise unexplained cerebral ischemia? ### Response:
We identified PT G20210A but not FVL - the strongest genetic risk factor for deep venous thrombosis - to be significantly associated with stroke attributed to PFO. These findings rise doubts about the concept of paradoxical brain embolism as the dominating mechanism in stroke associated with PFO.
### Instruction: Do motivational brochures increase the number of medicare-eligible persons with diabetes making therapeutic footwear claims? ### Response:
Mailed motivational brochures were associated with an increase in the number of persons making therapeutic footwear claims. Randomized trials should confirm these findings.
### Instruction: Does weight loss in combination with physical activity improve endothelial dysfunction in human obesity? ### Response:
Our data demonstrate that energy-restricted diet associated with physical activity induce a significant and clinically relevant improvement in ACh-stimulated vasodilation in obese healthy subjects.
### Instruction: Does correlation of subcellular compartmentalization of HPMA copolymer-Mce6 conjugate with chemotherapeutic activity in human ovarian carcinoma cells? ### Response:
Nuclear delivery was observed for P-NLS(FITC)-GG-Mce6 and P-NLS(FITC)-GFLG-Mce6 indicating NLS was a feasible approach for nuclear delivery. Due to the cationic nature of NLS, increased membrane binding of PDT systems incorporating cationic nuclear targeting moieties must be addressed.
### Instruction: Is glutamine infusion during ischemia detrimental in a murine gut ischemia/reperfusion model? ### Response:
GLN infusion during ischemia is detrimental for survival after gut I/R. A possible mechanism is excessive priming of myeloid cells caused by GLN infusion. Timing of GLN administration is critical for outcome after gut ischemic insult.
### Instruction: Does gastric inhibitory polypeptide ( GIP ) dose-dependently stimulate glucagon secretion in healthy human subjects at euglycaemia? ### Response:
Glucagon secretion is dose-dependently stimulated by GIP at basal glucose concentrations. The absence of a glucagonotropic GIP effect in previous studies could be due to the hyperglycaemic conditions used in these experiments. Our results underline differences between GIP and the glucagonostatic incretin GLP-1.
### Instruction: Does extent of parietal peritonectomy change intraperitoneal chemotherapy pharmacokinetics? ### Response:
The extent of parietal peritoneal resection did not affect the pharmacokinetics of intraoperative intraperitoneal chemotherapy. The pharmacological barrier between the abdominopelvic cavity and plasma is not directly related to an intact peritoneum.
### Instruction: Is [ Coding single nucleotide polymorphism an ideal marker for detecting gene imprinting by 5 ' nuclease assay ]? ### Response:
Coding SNP is an ideal marker for detecting gene imprinting by 5' nuclease assay. This approach has also a potentiality to discover differential allele expression of non-imprinted genes in order to find gene cis-acting functional polymorphism.
### Instruction: Is reduced expression of p27 correlated with progression in precancerous lesions of the larynx? ### Response:
Our results revealed that immunohistochemical assessment of p27 in bioptic samples of laryngeal precancerous lesions might be useful in selective patients who should undergo a more specific follow-up evaluation.
### Instruction: Does neurotrophin-3 modify potassium currents in isolated inner hair cells from guinea-pig cochlea? ### Response:
NT-3 suppressed the amplitude of K current on IHCs, suggesting that neurotrophins are capable of potentiating the hair cells' excitability. Neurotrophins may have a therapeutic value in the prevention and treatment of hearing impairment caused by inner ear damage.
### Instruction: Is nOTCH4 gene promoter polymorphism associated with the age of onset in schizophrenia? ### Response:
The NOTCH4 T-25C polymorphism has an important effect on the age of onset in schizophrenia and thus may be related to an early pathogenesis of schizophrenia in young patients. Alternatively, these findings may represent a significant genetic marker for managing subgroups and etiological clues in schizophrenia.
### Instruction: Are the splice variants 120 and 164 of the angiogenic peptide vascular endothelial cell growth factor ( VEGF ) expressed during Achilles tendon healing? ### Response:
These results prove the presence of the splice variants VEGF(120 )and VEGF(164) in ruptured tendons during the healing process. The demonstrated up-regulation of VEGF in intrinsic tenocytes suggests a role for VEGF in mechanisms of angiogenesis and Achilles tendon repair. Further research is needed to evaluate if VEGF might be a possible tool to enhance the process of tendon healing.
### Instruction: Is re-operation frequently required when parathyroid glands remain after initial parathyroidectomy for advanced secondary hyperparathyroidism in uraemic patients? ### Response:
To prevent persistent 2HPT, all parathyroid glands must be found and resected during the initial operation. Even if small parathyroid glands remain, there is a risk of progression. Complete PTx is the first treatment choice for advanced 2HPT.
### Instruction: Is scalp hypothermia to prevent chemotherapy-induced alopecia effective and safe : a pilot study of a new digitized scalp-cooling system used in 74 patients? ### Response:
The digitized, controlled, scalp-cooling system represents an effective and safe device that should be clinically evaluated in a randomized trial and in studies using other chemotherapy regimens to determine optimal temperatures and durations of cooling for maximal efficacy.
### Instruction: Do cardiomyocytes derived from embryonic stem cells resemble cardiomyocytes of the embryonic heart tube? ### Response:
Together, these data suggest that most cardiomyocytes acquired by differentiation of embryonic stem cells maintain a phenotype reminiscent of that of the cardiomyocytes of the primary heart tube, and hardly any myocytes develop a chamber myocardial phenotype.
### Instruction: Does loss of heterozygosity on chromosome 17p predict neoplastic progression in Barrett 's esophagus? ### Response:
Loss of heterozygosity at 17p11.1-p13 on chromosome 17p identifies patients with Barrett's esophagus at risk of neoplastic progression and can supplement histology in determining the frequency of endoscopy during surveillance.
### Instruction: Is delta ( 13 ) C-urea breath test value a useful indicator for Helicobacter pylori eradication in patients with functional dyspepsia? ### Response:
The 13C-UBT is a reliable semiquantitative test to assess H. pylori density and the activity and degree of gastritis. It is proposed that H. pylori eradication therapy might be beneficial for patients with functional dyspepsia with a delta 13C-UBT of >58.2 per thousand.
### Instruction: Does cytokeratin 7 staining of hepatocytes predict progression to more severe fibrosis in alcohol-fed baboons? ### Response:
In alcohol-fed baboons, cytokeratin 7 staining of hepatocytes (but not cytokeratin 19, nor fat deposition) predicts with a high degree of sensitivity and specificity progression to more severe liver disease.
### Instruction: Does constitutive over-expression of the insulin receptor substrate-1 cause functional up-regulation of Fas receptor? ### Response:
These findings suggest that the increased growth caused by IRS-1 over-expression is balanced by constitutive activation of pro-death mechanisms. Failure of the IRS-1 Tg mice to develop liver cancer may be due to preservation of pro-growth, pro-death homeostasis mechanisms.
### Instruction: Is long tube decompression successful in 90 % of patients with adhesive small bowel obstruction? ### Response:
For patients with SBO due to adhesions, a trial with long tube decompression for 48 to 72 hours is recommended. For those who fail a trial with the long tube, laparotomy with enterolysis or bowel resection is indicated. If the operative findings indicate a high risk for recurrent obstruction, then long tube splinting of the small bowel should be considered.
### Instruction: Does the AGE inhibitor pyridoxamine inhibit lipemia and development of renal and vascular disease in Zucker obese rats? ### Response:
Lipids are an important source of chemical modification of tissue proteins, even in the absence of hyperglycemia. PM inhibited AGE/ALE formation and hyperlipidemia and protected against renal and vascular pathology in a nondiabetic model.
### Instruction: Do [ Study on pharmacology of ultra-fine particles compound Rehmannia ]? ### Response:
Ultra-fine particles of six ingredient Rehmannia pill are better than traditional six ingredient Rehmannia pill in bioavailability and pharmacology actions, and the weight of pill is reduced while efficacy is enhenced by ultra-fine particles.
### Instruction: Does intravitreal dexamethasone effectively reduce postoperative inflammation after vitreoretinal surgery? ### Response:
Intravitreal dexamethasone significantly alleviates postoperative inflammation after vitreous surgery and is a useful adjunct.
### Instruction: Do mast cells play a partial role in allergen-induced subepithelial fibrosis in a murine model of allergic asthma? ### Response:
These findings suggest that mast cells play a partial role in the development of allergen-induced subepithelial fibrosis, although airway inflammation, epithelial remodelling and BHR caused by repeated allergen challenge are independent of mast cells, at least in this model.
### Instruction: Is biliary bile acid concentration a simple and reliable indicator for liver function after hepatobiliary resection for biliary cancer? ### Response:
Biliary bile acid concentration could be a simple, real-time, reliable indicator of preoperative and postoperative liver function.
### Instruction: Is periodontal disease associated with brachial artery endothelial dysfunction and systemic inflammation? ### Response:
Subjects with advanced periodontal disease exhibit endothelial dysfunction and evidence of systemic inflammation, possibly placing them at increased risk for cardiovascular disease.
### Instruction: Does angiotensin II inhibit endothelial cell motility through an AT1-dependent oxidant-sensitive decrement of nitric oxide availability? ### Response:
All together, our data demonstrate that angiotensin II inhibits HUVEC motility by reducing NO availability. Such reduction is due to an angiotensin II type 1 receptor-dependent increment in intracellular ROS generation.
### Instruction: Does survey of the use of suction drain in head and neck surgery and analysis of their biomechanical properties? ### Response:
Postoperative drain management has important implications in surgical wound healing. Drain reservoirs should be monitored frequently to ensure adequate compression, particularly in the first 24 hours after insertion. Anticipated volume of drainage should dictate in part which reservoir is chosen. A larger reservoir is preferable in most cases. Drains should be removed promptly to decrease the risk of wound contamination.
### Instruction: Is cerebrovascular pressure reactivity related to global cerebral oxygen metabolism after head injury? ### Response:
There is a close relation between dysautoregulation and abnormal cerebral metabolism but not blood flow. Further studies are needed to determine whether metabolic dysfunction is a result of or a cause of disturbed pressure reactivity, and to establish if there is a relation between cerebral oxygen metabolism and outcome.
### Instruction: Are frequency and intensity of responses to mite patch tests lower in nonatopic subjects with respect to patients with atopic dermatitis? ### Response:
Although positive responses to mite patch tests are also observable in subjects without AD, their frequency and intensity are significantly lower compared with AD patients.
### Instruction: Does the R271W mutant form of Pit-1 act as a dominant inhibitor of Pit-1 action to activate the promoters of GH and prolactin genes? ### Response:
Taken together with the evidence that phenotypically normal cases have been reported with this mutation, our results deny the relationship between R271W and combined pituitary hormone deficiency.
### Instruction: Is calcium-sensing receptor gene polymorphism associated with bone mineral density in Italian postmenopausal women? ### Response:
Our data do not support a role of A986S CaR polymorphism in BMD and in the prevalence of fragility fractures in Italian postmenopausal women.
### Instruction: Does r136K fibroblast growth factor-1 mutant induce heparin-independent migration of endothelial cells through fibrin glue? ### Response:
Site-directed mutagenesis of FGF-1 to R136K enables induction of heparin-independent migration of EC through fibrin glue at an optimal concentration of 100 ng/mL. Neither FGF-1 nor R136K elicits SMC migration through fibrin glue. The ability of R136K to induce EC migration through fibrin glue in the absence of heparin may prove useful in vivo by inducing EC migration and coverage of arterial injury sites, thus potentially reducing thrombogenicity and intimal hyperplasia.
### Instruction: Do wall shear stress and strain modulate experimental aneurysm cellularity? ### Response:
High flow conditions stimulate endothelial cell and smooth muscle cell proliferation in experimental aneurysms. Enhanced cellularity may stabilize aortic integrity, limiting aneurysm growth. Increased lower extremity activity may prevent or retard AAA disease through salutary effects on aortic remodeling mediated by endothelial cells and smooth muscle cells.
### Instruction: Does blood pressure at which rebleeding occur after resuscitation in swine with aortic injury? ### Response:
There was a reproducible pressure at which rebleeding occurred in this model of uncontrolled hemorrhage. The optimal endpoint of resuscitation in patients without definitive hemorrhage control would then be below this rebleeding pressure.
### Instruction: Does cardiovascular reactivity to stress predict future blood pressure in adolescence? ### Response:
This study adds to the pediatric literature documenting an association between cardiovascular reactivity to stress and subsequent risk for hypertension. It is the first to show that impedance-derived measures of myocardial function during stress are related to future blood pressure levels.
### Instruction: Does high-resolution comparative genomic hybridisation yield a high detection rate of chromosomal aberrations in childhood acute lymphoblastic leukaemia? ### Response:
HRCGH is superior to conventional CGH as an adjunct to G-band karyotyping as it detects recurrent aberrations at a significantly higher rate than both these techniques.
### Instruction: Do increased serum levels of matrix metalloproteinase-9 predict clinical outcome of patients with early B-cell chronic lymphocytic leukaemia? ### Response:
MMP-9 serum levels predict disease behaviour and help to refine the prognosis of stage A CLL patients.
### Instruction: Does oxidative DNA damage in human sperm influence time to pregnancy? ### Response:
The data suggest that oxidative damage to sperm DNA influences fecundity and the level of damage is relatively constant within an individual and not influenced by smoking.
### Instruction: Does a novel diamino-pyridine derivative ( IS-741 ) attenuate rat ileitis induced by trinitrobenzene sulfonic acid? ### Response:
These results indicate that the oral administration of IS-741 inhibits neutrophil infiltration into inflamed lesions, and is effective for attenuating rat TNBS ileitis. This new anti-inflammatory agent may be beneficial for the treatment of inflammatory bowel disease.
### Instruction: Is altered response to tryptophan supplementation after long-term abstention from MDMA ( ecstasy ) highly correlated with human memory function? ### Response:
Our results suggest that prolonged abstinence from MDMA might be associated with altered tryptophan metabolism. Ex-users showing the poorest memory function at baseline were also those who metabolised least tryptophan. These findings may reflect pre-morbid differences in 5-HT function of those who stop using this drug or consequences of MDMA use that emerge after abstention. Aggression is also associated with MDMA use and subsequent abstinence.