Datasets:
typosonlr
/
PubMedPreProcessed

Dataset card Data Studio Files
xet
Community
1
question
stringlengths
52
373
long_answer
stringlengths
1
3.34k
### Instruction: Is urinary creatinine concentration inversely related to glycaemic control and the presence of some diabetic complications in patients with newly diagnosed Type 2 diabetes? ### Response:
The use of albumin/creatinine ratio (ACR) may introduce bias of unpredictable size and direction in comparisons of ACR with variables that are associated with UCC in their own right. In daily clinical practice, renal involvement in the individual patient can be estimated reliably with UAC or ACR measured in a freshly voided morning urine specimen, especially when considered together. However, the associations of the combined measure ACR should be interpreted with great caution in clinical and epidemiological research.
### Instruction: Is antibody immunity to the p53 oncogenic protein a prognostic indicator in ovarian cancer? ### Response:
Data presented here demonstrate that advanced stage ovarian cancer patients can have detectable tumor-specific antibody immunity and that immunity to p53 may predict improved overall survival in patients with advanced-stage disease.
### Instruction: Does revascularization of autogenous block graft with or without an e-PTFE membrane? ### Response:
The results emphasized the importance of the vascular network and of the revascularization process of the autogenous bone graft in new bone formation. Early vascular penetration and nutrition of the graft are key factors in its integration with the recipient bed.
### Instruction: Do in vitro evaluation of bacterial leakage along the implant-abutment interface of different implant systems? ### Response:
The degree of penetration in a specific implant system presumably is a multifactorial condition dependent on the precision of fit between the implant and the abutment, the degree of micromovement between the components, and the torque forces used to connect them.
### Instruction: Are bone mineral density and bone histomorphometry statistically related? ### Response:
The results of this study support the use of QCT to assess the bone quality before implant placement to improve the planning of implant treatment.
### Instruction: Do mscS-like proteins control plastid size and shape in Arabidopsis thaliana? ### Response:
Our data support a model wherein MSL2 and MSL3 control plastid size, shape, and perhaps division during normal plant development by altering ion flux in response to changes in membrane tension. We propose that MscS family members have evolved new roles in plants since the endosymbiotic event that gave rise to plastids.
### Instruction: Are cerebral microbleeds common in ischemic stroke but rare in TIA? ### Response:
Microbleeds are common in ischemic stroke but rare in TIA, an observation not explained by differences in vascular risk factors or severity of white matter disease seen on T2 MRI. This finding has implications for the safety of antithrombotic therapy and clinical trial design in the two groups. Microbleeds may also be a new marker for severe microvascular pathology with increased risk of permanent cerebral infarction.
### Instruction: Does high-frequency QRS electrocardiogram predict perfusion defects during myocardial perfusion imaging? ### Response:
Analysis of 12-lead HF QRS ECG is highly sensitive and reasonably specific for detecting perfusion defects during adenosine MPI stress tests and significantly more sensitive than analysis of conventional ST segments.
### Instruction: Does the circadian rhythm of tryptophan in breast milk affect the rhythms of 6-sulfatoxymelatonin and sleep in newborn? ### Response:
A temporal relationship was observed between the circadian rhythm of 6-sulfatoxymelatonin of the exclusively breast-fed babies and that of tryptophan in the mother's milk. Acting this amino acid as a zeitgeber entrainment of the biological rhythms in the breast-fed infant.
### Instruction: Is heated , humidified CO2 gas unsatisfactory for awake laparoscopy? ### Response:
Heated, humidified CO2 gas insufflation does not reduce pain sufficiently to permit satisfactory performance of laparoscopy with local anesthesia, especially when full volume insufflation is required. Cold, dry helium gas produces no pain. The theory that cold, dry insufflation gas is a source of peritoneal pain during laparoscopy needs to be reassessed.
### Instruction: Is increased serum resistin in nonalcoholic fatty liver disease related to liver disease severity and not to insulin resistance? ### Response:
Both NAFLD and obese patients had lower adiponectin levels, whereas leptin was increased only in the obese group. No correlation was found between resistin and high-sensitivity C-reactive protein, BMI, homeostasis model assessment, insulin, glucose, transaminases, and lipid values. A positive correlation was found between resistin and histological inflammatory score. These data report increased resistin in NAFLD patients that is related to the histological severity of the disease, but do not support a link between resistin and insulin resistance or BMI in these patients.
### Instruction: Do lifestyle risk factors predict healthcare costs in an aging cohort? ### Response:
Seniors who were leaner, smoked fewer cigarettes over a lifetime, reduced their smoking, or walked farther had significant subsequent cost savings compared to those with less-healthy lifestyle-related habits.
### Instruction: Do [ Evaluation of duration for direct admission dispatch process in an urban area ]? ### Response:
The average duration of direct admission dispatch process is acceptable. The increased duration of direct admission dispatch process in some pathology during summer may induce a risk for the patients. This problem will be improved only when the management of the available bed for emergency traumatology, will be implemented a regional coordination.
### Instruction: Is pulmonary arterial hypertension a major mortality factor in diffuse systemic sclerosis , independent of interstitial lung disease? ### Response:
These results indicate that, independent of ILD, PAH is a major prognostic factor for survival in dcSSc.
### Instruction: Does hypertonic saline resuscitation after mesenteric ischemia/reperfusion induce ileal apoptosis? ### Response:
HS resuscitation after mesenteric I/R significantly increased ileal mucosal apoptosis while decreasing mucosal injury and may represent a novel mechanism by which HS resuscitation after mesenteric I/R reduces inflammation and imparts protection to the gut.
### Instruction: Does immunoglobulin a modulate inflammatory responses in an in vitro model of pneumonia? ### Response:
PMN cytotoxic potential was decreased by the presence of SIgA but not IgG in an in vitro model to simulate pneumonia in vivo. SIgA may not only function to protect against microbial invasion of mucosal surfaces, but may also protect against tissue injury from an exaggerated inflammatory response.
### Instruction: Are pyridine N-oxide derivatives inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture? ### Response:
A wide variety of pyridine N-oxide derivatives have been found to be inhibitory against feline coronavirus (FIPV strain) and human SARS-CoV (Frankfurt strain-1) in CRFK and simian kidney (Vero) cell cultures, respectively. The oxide part on the pyridine moiety proved indispensable for anti-coronavirus activity. The potency and virus specificity of the pyridine N-oxide derivatives varied depending the nature and specific location of substituents (i.e. alkyl, halogeno, nitro, etc.) on the different parts of the molecule. The most selective compounds were active in the higher microgram per litre range, being non-toxic at 50-100 mg/L. There was a poor structure-antiviral activity relationship (SAR) for the pyridine N-oxide derivatives against Fe-CoV and SARS-CoV. One of the most active and selective compounds was shown to inhibit Fe-CoV replication at the transcriptional level.
### Instruction: Does increased myocardial performance index correlate with biopsy-proven rejection in pediatric heart transplant recipients? ### Response:
In this series, increased LVMPI correlated with biopsy-proven rejection, and frequent serial assessments using this technique may provide a relatively sensitive non-invasive means of rejection surveillance after pediatric cardiac transplantation. False positive results may be encountered, likely due to alterations in diastolic function that have been previously observed in transplant recipients.
### Instruction: Is expression of hepatoma-derived growth factor correlated with lymph node metastasis and prognosis of gastric carcinoma? ### Response:
HDGF expression level was shown to be a prognostic factor for gastric carcinoma.
### Instruction: Does reduced expression of CAMTA1 correlate with adverse outcome in neuroblastoma patients? ### Response:
Our data suggest that assessment of CAMTA1 expression may improve the prognostic models for neuroblastoma and that it will be important to define the biological function of CAMTA1 in this disease.
### Instruction: Is renal function well maintained after use of left renal vein graft for vascular reconstruction in hepatobiliary-pancreatic surgery? ### Response:
The left renal vein could be safely obtained and used for vascular reconstruction in resection of hepatobiliary-pancreatic malignancy without adverse effects on early and longterm renal function.
### Instruction: Does basement membrane matrix modify cytokine interactions between lung cancer cells and fibroblasts? ### Response:
These results suggest that the basement membrane acts as a barrier to the diffusion and a reservoir of cytokines secreted by cancer cells, and that the subsequent degradation of the basement membrane by cancer cells could release the stored cytokines and promote growth of fibroblasts.
### Instruction: Is overexpression of cyclooxygenase-2 associated with a favorable prognostic phenotype in breast carcinoma? ### Response:
The current data suggest that increased expression of COX-2 may be related to breast carcinomas with less aggressive phenotype. This suggestion is further supported by the positive correlation between COX-2 and PPARgamma, since the latter is considered to be indicative of a less malignant phenotype of tumor cells.
### Instruction: Does periodic direct current promote wound closure in an in vitro dynamic model of cell migration? ### Response:
Contrary to the authors' expectations, they found that periodic DC did not promote wound closure, a finding that emphasizes the need to clarify the complex effects of electrical fields on migrating cells.
### Instruction: Does mixed hematopoietic molecular chimerism result in permanent transgene expression from retrovirally transduced hepatocytes in mice? ### Response:
Creation of a molecular hematopoietic chimerism can result in transgene tolerance and evade immune rejection of retrovirally transduced hepatocytes. This strategy may be useful for hepatic inherited diseases in which the transgene product behaves as a non-self protein.
### Instruction: Do liver and skeletal muscle lipids have differing fatty acid profiles in short-gut rats fed via parenteral nutrition? ### Response:
Both the presence of short gut and type of PN led to increases in distal metabolites of fatty acids on omega:3 and omega:6 pathway in liver phospholipids but not in skeletal muscle during short-term PN feeding in rats.
### Instruction: Does feeding an elemental diet vs a milk-based formula decrease intestinal mucosal growth in infant pigs? ### Response:
We conclude that intestinal mucosal growth and villus morphology are similar in pigs fed ED and FORM, despite higher cell proliferation and protein synthesis rates and lower lactase activity with ED. This implies that elemental diets may be as trophic as polymeric formulas to simultaneously provide nutrition and a stimulus for intestinal growth during bowel rest.
### Instruction: Is ethanol-induced sensitization to endotoxin in Kupffer cells dependent upon oxidative stress? ### Response:
Ethanol causes tolerance in the early phase after ethanol consumption, while sensitization was observed later. Both tolerance and sensitization were induced by gut-derived endotoxin. These findings indicate that ethanol-induced both tolerance and sensitization of Kupffer cells to endotoxin involve IRAK expression. Further, NADPH oxidase plays a pivotal role in the increase in IRAK expression due to ethanol via activation of NFkappaB signaling pathway. In conclusion, these data indicate that acute ethanol causes sensitization to endotoxin through mechanisms dependent upon oxidative stress.
### Instruction: Is soluble tissue factor a candidate marker for progression of microvascular disease in patients with Type 2 diabetes? ### Response:
Soluble TF is associated with existing microvascular and neurogenic complications in patients with Type 2 diabetes and is a candidate marker for progression of microvascular disease.
### Instruction: Does n-acetyl-cysteine suppress amniotic fluid and placenta inflammatory cytokine responses to lipopolysaccharide in rats? ### Response:
NAC inhibition of inflammatory responses may protect the fetus from potential long-term sequelae.
### Instruction: Is fractional anisotropy higher in Heschl 's gyrus than in superior temporal gyrus in normal subjects? ### Response:
The FA in the subcortical white matter of the HG was higher than that of the STG in both hemispheres. These changes in DT imaging may be accounted for by the presence of the auditory radiations.
### Instruction: Does chronic fetal hypoxia increase activin A concentrations in the late-pregnant sheep? ### Response:
SUAL-induced IUGR and fetal hypoxaemia increases AF activin A. This may be an important adaptive or protective response to IUGR.
### Instruction: Are blood oxidative stress markers unreliable markers of hepatic steatosis? ### Response:
Standard blood oxidative stress markers do not predict the extent of hepatic steatosis as they probably do not accurately reflect intrahepatic oxidative stress. Serum lipid levels were best correlated with hepatic steatosis.
### Instruction: Does spinal manipulative therapy reduce inflammatory cytokines but not substance P production in normal subjects? ### Response:
SMT-treated subjects show a time-dependent attenuation of LPS-induced production of the inflammatory cytokines unrelated to systemic levels of SP. This suggests SMT-related down-regulation of inflammatory-type responses via a central yet unknown mechanism.
### Instruction: Are expression and activation of MMP -2 , -3 , -9 , -14 induced in rat colon after abdominal X-irradiation? ### Response:
This study brings new insights into ECM remodeling in the colon after exposure to ionizing radiation and highlights the role of MMP subtypes specialized in basement membrane degradation.
### Instruction: Does documentation in medical records improve after a neurointensivist 's appointment? ### Response:
Our findings suggest that a major change was implemented in the NICU regarding documentation after a neurointensivist was appointed. Although the direct or indirect impact of the appointment was not clarified, these preliminary data warrant a prospective ICU study, which should determine the exact variables that play a role in documentation, how they change over time, and what reinforcing mechanisms can be used.
### Instruction: Does genistein affect the expression of genes involved in blood pressure regulation and angiogenesis in primary human endothelial cells? ### Response:
Our data indicate that physiologically achievable levels of Gen change the expression of mRNA encoding for proteins involved in the control of blood pressure under baseline conditions and reduce the angiogenic response to oxLDL in the endothelium.
### Instruction: Do isovolumic but not ejection phase Doppler tissue indices detect left ventricular dysfunction caused by coronary stenosis? ### Response:
IVA detects changes in global LV systolic function during LAD constriction and may be a useful clinical tool to diagnose ischemia.
### Instruction: Does miR-155 Overexpression promote Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair? ### Response:
Taken together, miR-155 overexpression drives an increase in mutation frequency via multifaceted impact on DNA damage response and DNA repair pathways.
### Instruction: Is therapy with natalizumab associated with high JCV seroconversion and rising JCV index values? ### Response:
JCV seroconversion and index values may be influenced by treatment with natalizumab. It is therefore important to monitor patients' JCV serology but also to incorporate additional risk factors into the progressive multifocal leukoencephalopathy risk stratification.
### Instruction: Do patients with MS under daclizumab therapy mount normal immune responses to influenza vaccination? ### Response:
Despite the mild immunosuppressive effects of daclizumab in vivo demonstrated by an increased incidence of infectious complications in clinical trials, patients with MS under daclizumab therapy mount normal antibody responses to influenza vaccinations.
### Instruction: Does multidimensional endotyping in patients with severe asthma reveal inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1? ### Response:
In 2 distinct cohorts we have identified and replicated 6 clinicopathobiologic clusters based on blood and induced sputum measures. Our data underline a disconnect between clinical features and underlying inflammation, suggest IL-5 production is relatively steroid insensitive, and highlight the expression of YKL-40 in patients with neutrophilic inflammation and the expression of MMPs in patients with severe asthma.
### Instruction: Do stem cells improve the quality of colonic anastomoses - A systematic review? ### Response:
These findings suggest a novel role for mesenchymal stem cells in digestive sutures on ischemic conditions. Although stem cells have shown their beneficial effect on anastomotic healing, further studies are necessary to establish the indications, the appropriate method of administration, the sampling site and the identification of substances whose combination might potentiate their angiogenic effect.
### Instruction: Does nrf2 activator ameliorate hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation? ### Response:
BARD suppressed the exacerbation hemorrhage caused by warfarin pretreatment and ameliorated BBB disruption by protecting endothelial cells, pericytes, and tight junction protein expressions. These results indicate that Nrf2 activators may be an effective therapy against hemorrhagic transformation caused by anticoagulant drugs.
### Instruction: Does feedback activation of neurofibromin terminate growth factor-induced Ras activation? ### Response:
Our findings show that, in addition to feedback inhibition of Sos, feedback stimulation of the RasGAP neurofibromin enforces termination of the Ras signal in the context of growth-factor signaling. These findings ascribe a precise role to neurofibromin in growth factor-dependent control of Ras activity and illustrate how, by engaging Ras-GAP activity, mitogen-challenged cells play safe to ensure a timely termination of the Ras signal irrespectively of the reigning rate of nucleotide exchange.
### Instruction: Does matrix metalloproteinase-9 deletion rescue auditory evoked potential habituation deficit in a mouse model of Fragile X Syndrome? ### Response:
Fragile X Syndrome (FXS) is the leading known genetic cause of autism spectrum disorders. Individuals with FXS show symptoms of auditory hypersensitivity. These symptoms may arise due to sustained neural responses to repeated sounds, but the underlying mechanisms remain unclear. For the first time, this study shows deficits in habituation of neural responses to repeated sounds in the Fmr1 KO mice as seen in humans with FXS. We also report an abnormally high level of matrix metalloprotease-9 (MMP-9) in the auditory cortex of Fmr1 KO mice and that deletion of Mmp-9 from Fmr1 KO mice reverses habituation deficits. These data provide a translation relevant electrophysiological biomarker for sensory deficits in FXS and implicate MMP-9 as a target for drug discovery.
### Instruction: Is conservative strategy in infantile fibrosarcoma possible : The European paediatric Soft tissue sarcoma Study Group experience? ### Response:
Conservative therapy is possible in IFS as only three children required mutilating surgery, and alkylating or anthracycline based chemotherapy was avoided in 71.0% of patients needing chemotherapy. VA regimen should be first line therapy in order to reduce long term effects.
### Instruction: Do peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease? ### Response:
Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.
### Instruction: Do asymptomatic elite young tennis players show lateral and ventral growth plate alterations of proximal humerus on MRI? ### Response:
Significant findings assessing MRI measurements of the epiphyseal plate in the asymptomatic adolescent elite tennis player might reflect a development of consecutive alterations in the epiphyseal plate in the dominant arm.
### Instruction: Is resistance to thrombomodulin associated with de novo portal vein thrombosis and low survival in patients with cirrhosis? ### Response:
Owing to PVT results from the pro-coagulant imbalance occurring in patients with advanced cirrhosis, TM-R might serve as a predictor and could possibly be a biological mediator of adverse outcome in patients with advanced cirrhosis.
### Instruction: Are thirty percent of abstracts presented at dental conferences published in full : a systematic review? ### Response:
Less than one-third of abstracts presented at dental conferences were published in full more than 4 years after conference presentation.
### Instruction: Do endothelin ETA receptors predominate in chronic thromboembolic pulmonary hypertension? ### Response:
The presence of ET-1 receptors in the chronic thrombus in proximal CTEPH suggests ET-1 could act not only on the distal vasculopathy in the unobstructed vessels but may also stimulate smooth muscle cell proliferation within chronic clot. The abundance of ET receptors within the tissue provides evidence that the ET pathway is involved in the pathology of chronic thrombus reorganisation leading to CTEPH providing a rationale for the repurposing of ET receptor antagonists in the treatment of this condition.
### Instruction: Does intracoronary injection of tirofiban prevent microcirculation dysfunction during delayed percutaneous coronary intervention in patients with acute myocardial infarction? ### Response:
Intracoronary injection of tirofiban can significantly prevent the abnormal increase of IMR value during delayed PCI in patients with acute myocardial infarction.
### Instruction: Is early Trauma-Induced Coagulopathy Associated with Increased Ventilator-Associated Pneumonia in Spinal Cord Injury Patients? ### Response:
Coagulopathy on admission in patients with spinal cord injury is associated with a statistically significant increase in ventilator-associated pneumonia incidence. Additional research is warranted to further characterize this association.
### Instruction: Does molecular Staging of Sentinel Lymph Nodes identify Melanoma Patients at Increased Risk of Nodal Recurrence? ### Response:
Patients with microscopically negative/PCR+ SLN have an increased risk of nodal recurrence that was mitigated by CLND. Although CLND did not affect OS, these data suggest that molecular detection of melanoma-specific mRNA in the SLN predicts a greater risk of nodal recurrence and deserves further study.
### Instruction: Does interferon-γ enhance the efficacy of autogenous bone grafts by inhibiting postoperative bone resorption in rat calvarial defects? ### Response:
Local IFN-γ administration promoted bone formation in autogenous bone grafts possibly via regulating osteoclastogenesis and TNF-α expression. The data provide insights into the potential roles of IFN-γ in autogenous bone grafting.
### Instruction: Is a novel mutation in CELSR1 associated with hereditary lymphedema? ### Response:
CELSRI may be responsible for primary, non-syndromic lymphedema in humans.
### Instruction: Does a biophysical model of supercoiling dependent transcription predict a structural aspect to gene regulation? ### Response:
Our model, incorporating the supercoiling state of the gene, makes specific predictions that differ from previous models of gene expression. Genes in the same supercoiling domain influence the expression level of neighboring genes. Such structurally dependent regulation predicts correlations between genes in the same supercoiling domain. The topology of the chromosome therefore creates a higher level of gene regulation, which has broad implications for understanding the evolution and organization of bacterial genomes.
### Instruction: Does epidermal growth factor receptor inhibitor AG1478 inhibit mucus hypersecretion in airway epithelium? ### Response:
These results indicated that EGFR transactivation plays an important role in mucin and IL-8 secretion from airway epithelial cells. Intranasal instillation of an EGFR tyrosine kinase inhibitor may be a new therapeutic approach for the treatment of upper airway inflammation.
### Instruction: Does whole Genome Analysis of Injectional Anthrax identify Two Disease Clusters Spanning More Than 13 Years? ### Response:
Genome-based differentiation of injectional anthrax isolates argues for at least two separate disease events spanning > 12 years. The genomic similarity of the two clusters makes it likely that they are caused by separate contamination events originating from the same geographic region and perhaps the same site of drug manufacturing or processing. Pathogen diversity within single patients challenges assumptions concerning population dynamics of infecting B. anthracis and host defensive barriers for injectional anthrax.
### Instruction: Is tuberculous Pericarditis Multibacillary and Bacterial Burden Drives High Mortality? ### Response:
Patients with culture confirmed tuberculous pericarditis have a high bacillary burden, and this bacterial burden drives mortality. Thus proven tuberculosis pericarditis is not a paucibacillary disease. Moreover, the severe immunosuppression suggests limited inflammation. There is a need for the design of a highly bactericidal regimen for this condition.
### Instruction: Is cytologic atypia in the contralateral unaffected breast related to parity and estrogen-related genes? ### Response:
Cytologic atypia, and particularly anisonucleosis, is associated with recent and multiple births and ER negative status of the index tumor. Atypical samples showed increased expression of estrogen-related genes, consistent with the role of estrogen exposure in breast cancer development.
### Instruction: Does ocular Fluid Analysis in Children reveal Interleukin-29/Interferon-λ1 as a Biomarker for Juvenile Idiopathic Arthritis-Associated Uveitis? ### Response:
We identified IL-29/IFNλ1 as an intraocular biomarker for JIA-associated uveitis, which suggests that aberrant IFNλ signaling might be important in JIA-associated uveitis and distinct from other forms of childhood uveitis.
### Instruction: Do glucocorticoid receptor polymorphisms modulate cardiometabolic risk factors in patients in long-term remission of Cushing 's syndrome? ### Response:
The 9β and BclI polymorphisms of the GR adversely affect the cardiometabolic profile in patients who are in remission after the treatment of CS. This suggests that genetically altered GC sensitivity modulates the long-term adverse cardiometabolic effects resulting from (endogenous) hypercortisolism.
### Instruction: Is `` Food Addiction '' in Patients with Eating Disorders Associated with Negative Urgency and Difficulties to Focus on Long-Term Goals? ### Response:
Eating disorder patients who have more problems to pursue tasks to the end and to focus on long-term goals seem to be more likely to develop addictive eating patterns.
### Instruction: Does nicotine inhibit the production of proinflammatory cytokines of mice infected with coxsackievirus B3? ### Response:
The results indicate that cholinergic stimulation with nicotine significantly reduced the severity of viral myocarditis in mice. The findings suggest that alpha7 nAChR agonists may be a promising new strategy for patients with myocarditis.
### Instruction: Does ponatinib attenuate experimental pulmonary arterial hypertension by modulating Wnt signaling and vasohibin-2/vasohibin-1? ### Response:
Our results identified a therapeutic potential of AP in PAH therapy might be modulated VASH-2/VASH-1 and the Wnt signaling.
### Instruction: Are lactoferrin Levels in Tears Increased by the Topical Application of Diadenosine Tetraphosphate? ### Response:
Topical application of diadenosine tetraphosphate stimulates the secretion of lactoferrin in rabbit tears through P2 receptor activation.
### Instruction: Is higher PDCD4 expression associated with obesity , insulin resistance , lipid metabolism disorders , and granulosa cell apoptosis in polycystic ovary syndrome? ### Response:
Our study suggests for the first time that higher PDCD4 expression might play an important role in PCOS pathogenesis by affecting obesity, insulin resistance, lipid metabolism disorders, and GC apoptosis.
### Instruction: Does missense Variant in MAPK Inactivator PTPN5 be Associated with Decreased Severity of Post-Burn Hypertrophic Scarring? ### Response:
We report PTPN5 as a novel genetic locus associated with HTS severity. PTPN5 is a MAPK inhibitor expressed in neurons, suggesting a potential role for neurotrophic factors and neuroinflammatory signaling in HTS pathophysiology.
### Instruction: Do gender and frailty predict poor outcomes in infrainguinal vascular surgery? ### Response:
Female gender and frailty are both associated with increased risk of complications and death following infrainguinal vascular procedures with the highest risk in frail females. Further studies are needed to explore the mechanisms of interaction of gender and frailty and its effect on long-term outcomes for peripheral vascular disease.
### Instruction: Does reasons for discrepancies in hip fracture risk estimate using FRAX and Garvan calculators? ### Response:
Hip fracture risk estimates are usually higher with Garvan than FRAX, and these differences could impact on treatment decisions in about a quarter of patients. Falls and multiple fractures have a strong influence on Garvan risk estimates, when present. Clinically important discrepancies tend to occur in patients who are at borderline fracture risk. In patients with hip fracture risks near the treatment threshold with one calculator, use of the other calculator should be considered to help guide treatment decisions.
### Instruction: Does an integrated molecular landscape implicate the regulation of dendritic spine formation through insulin-related signalling in obsessive-compulsive disorder? ### Response:
This study is a first attempt to integrate molecuar information from different sources in order to identify biological mechanisms underlying OCD etiology. Our findings are constrained by the limited information from hypothesis-free studies and the incompleteness and existing limitations of the OCD literature and the gene function annotations of gene enrichment tools. As this study was solely based on in silico analyses, experimental validation of the provided hypotheses is warranted.
### Instruction: Do fractures lead to worsening of disease activity in rheumatoid arthritis? ### Response:
We have demonstrated that fractures influence disease activity in patients with RA. Larger numbers of fracture cases are required to confirm the present observations; however, the prevention of fracture is clearly required in patients with RA.
### Instruction: Does microRNA-30a promote chondrogenic differentiation of mesenchymal stem cells through inhibiting Delta-like 4 expression? ### Response:
Our results indicate that miR-30a acts as a key promoter for chondrogenic differentiation of MSCs by down-regulating DLL4 expression, and provide a novel insight on miRNA-mediated MSC therapy for cartilage-related disorders including osteoarthritis.
### Instruction: Does decreased Cystatin C-Estimated Glomerular Filtration Rate be Correlated with Prolonged Hospital Stay in Transient Tachypnea of Newborn Infants? ### Response:
Tachypnea duration was shorter with higher Cys C-based eGFR in infants with TTN.
### Instruction: Are high levels of cathepsin D and cystatin B associated with increased risk of coronary events? ### Response:
The associations of cathepsin D and cystatin B with future CE provide clinical support for a role of these factors in cardiovascular disease, which for cathepsin D may be of particular importance for smokers.
### Instruction: Does the MacNew Questionnaire be a Helpful Tool for Predicting Unplanned Hospital Readmissions After Coronary Revascularization? ### Response:
A relatively elevated MacNew global score appears to be associated with a significantly decreased risk of unscheduled hospitalizations after coronary revascularization over a 3-year follow-up.
### Instruction: Does demethylation of tumor necrosis factor-α converting enzyme predict poor prognosis in acute-on-chronic hepatitis B liver failure? ### Response:
This study showed that demethylation of TACE promoter occurred in ACHBLF and might serve as a potential prognostic marker.
### Instruction: Does lRG1 modulate epithelial-mesenchymal transition and angiogenesis in colorectal cancer via HIF-1α activation? ### Response:
The present study suggests that LRG1 plays a crucial role in the progression of CRC by regulating HIF-1α expression, thereby may be a promising therapeutic target of CRC.
### Instruction: Is the face bow irrelevant for making prostheses and planning orthognathic surgery? ### Response:
Eliminating the face bow transfer reduces the patient's chair time and the dentist's overhead expenses. The author found evidence in the results of randomized controlled trials and an online video that justify eliminating the use and teaching of the 133-year-old technique known as the face bow transfer.
### Instruction: Does perioperative Dexamethasone Administration Increase the Incidence of Postoperative Infection in Total Hip and Knee Arthroplasty : A Retrospective Analysis? ### Response:
A single intravenous perioperative dose of dexamethasone had no statistically significant difference in the rate of PJI after total hip or knee arthroplasty.
### Instruction: Does tissue-Engineered Skin Substitute enhance Wound Healing after Radiation Therapy? ### Response:
These results indicate that BTESS is the preferred treatment for irradiated wound ulcers.
### Instruction: Is cell phone use associated with an inflammatory cytokine profile of parotid gland saliva? ### Response:
The exposure of parotid glands to cell phones can alter salivary IL-10 and IL-1β levels, consistent with a pro-inflammatory microenvironment that may be related to heat production.
### Instruction: Is placental MFSD2a transporter related to decreased DHA in cord blood of women with treated gestational diabetes? ### Response:
In offspring of women with GDM treated either with diet or insulin, higher fetal fat accretion and lower placental MFSD2a contribute to reduce DHA availability. Lyso-PL appear to contribute to materno-fetal DHA transport.
### Instruction: Does branched-chain amino acid supplementation attenuate a decrease in power-producing ability following acute strength training? ### Response:
BCAA administered acutely before and following intensive ST attenuates a decrease in power-producing ability experienced by resistance-trained males. The apparent small but significant effects on functional power suggest that BCAA is an effective ergogenic aid for athletes who require augmented recovery of power-producing ability following intensive ST.
### Instruction: Is receptor for advanced glycation end products expressed on alveolar epithelial cells the main target for hyperoxia-induced lung injury? ### Response:
These results indicated that RAGE on AECs mainly contributed to hyperoxia-induced lung injury and alveolar-capillary barrier disruption.
### Instruction: Are isolated tumor cells in stage I & II colon cancer patients associated with significantly worse disease-free and overall survival? ### Response:
This study provides compelling evidence that ITC in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival. Based on these data, the presence of ITC should be classified as a high risk factor in stage I & II colon cancer patients who might benefit from adjuvant chemotherapy.
### Instruction: Does human papillomavirus vaccination induce neutralising antibodies in oral mucosal fluids? ### Response:
We provide experimental proof that HPV-vaccination elicits neutralising antibodies to the vaccine-targeted types in oral fluids. Hence, immunisation may confer direct protection against type-specific HPV infection and associated diseases of the oropharyngeal tract. Measurement of antibodies in oral fluids represents a suitable tool to assess vaccine-induced protection within the mucosal milieu of the orophayrynx.
### Instruction: Does large Size Hemicraniectomy reduce Early Herniation in Malignant Middle Cerebral Artery Infarction? ### Response:
Despite a more aggressive surgical approach, eDHC may reduce early in-hospital mortality and limit transtentorial herniation. Prospective studies are warranted to confirm our results and assess general safety of eDHC.
### Instruction: Are failure of tooth eruption and brachydactyly in pseudohypoparathyroidism related to plasma parathyroid hormone-related protein levels? ### Response:
We described the dental abnormalities in a large series of PHP patients that were followed in a single tertiary center. No relationship between plasma PTHrP levels and failure of tooth eruption, dental manifestations of PHP or brachydactyly was found. It is important that doctors pay attention to dental manifestations of the disease in order to refer patients to a proper care with dentists.
### Instruction: Are adrenal-derived 11-oxygenated 19-carbon steroids the dominant androgens in classic 21-hydroxylase deficiency? ### Response:
All four 11oxC19 steroids are elevated in both men and women with classic 21OHD. Our data suggest that 11oxC19 steroids are specific biomarkers of adrenal-derived androgen excess.
### Instruction: Does diffuse parathyroid hormone expression in parathyroid tumors argue against important functional tumor subclones? ### Response:
No areas with apparently higher PTH expression were identified, perhaps suggesting that hyper functioning parathyroid tumor subclones should be rare. Circulating 25-hydroxyvitamin D levels may influence tumor PTH expression in vivo. If PTH immunoreactivity reflects the tumor calcium-PTH set point, our data imply that the main determinant of disease severity should be tumor weight.
### Instruction: Does a Common Polymorphism in a Williams Syndrome Gene predict Amygdala Reactivity and Extraversion in Healthy Adults? ### Response:
A common polymorphism in the WS gene GTF2I associated with reduced social anxiety predicts decreased threat-related amygdala reactivity, which mediates an association between genotype and increased warmth in women. These results are consistent with reduced threat-related amygdala reactivity in WS and suggest that common variation in GTF2I contributes to broader variability in socioemotional brain function and behavior, with implications for understanding the neurogenetic bases of WS as well as social anxiety.
### Instruction: Do community prevalence of long-term urinary catheters use in England? ### Response:
Previous evidence on prevalence of long term catheter use is sparse, and of variable quality. The strength of this study is utilisation of a reliable source of data (catheter prescriptions) from a large population of patients. Neurourol. Urodynam. © 2016 Wiley Periodicals, Inc.
### Instruction: Does subjective memory decline predict greater rates of clinical progression in preclinical Alzheimer 's disease? ### Response:
High SMD is a harbinger of greater rates of clinical progression in preclinical AD. Although SMD reflects broader diagnostic implications for CN Aβ+, more sensitive measures may be required to detect early subtle cognitive change.
### Instruction: Does inter-tissue coexpression network analysis reveal DPP4 as an important gene in heart to blood communication? ### Response:
In summary, this is the first resource of human multi-tissue networks enabling the investigation of molecular inter-tissue interactions. With the networks in hand, we may systematically design combination therapies that simultaneously target multiple tissues or pinpoint potential side effects of a drug in other tissues.
### Instruction: Are higher mitochondrial potential and elevated mitochondrial respiration associated with excessive activation of blood platelets in diabetic rats? ### Response:
Long-term diabetes can result in increased mitochondrial mass and may lead to hyperpolarization of blood platelet mitochondrial membrane. These alterations may be a potential underlying cause of abnormal platelet functioning in diabetes mellitus and hence, a potential target for antiplatelet therapies in diabetes.
### Instruction: Is hAL-RAR ( Doppler guided haemorrhoid artery ligation with recto-anal repair ) a safe and effective procedure for haemorrhoids . Results of a prospective study after two-years follow-up? ### Response:
HAL-RAR is safe and almost painless technique and it has very good results in the control of haemorrhoidal symptoms. This procedure should be considered as an effective first treatment option for haemorrhoids.
### Instruction: Does sMicroRNA-1290 inhibit cells proliferation and migration by targeting FOXA1 in gastric cancer cells? ### Response:
miR-1290 promotes gastric tumor cells proliferation and metastasis through FOXA1, which could be used as a marker for diagnosis and a target for therapeutic intervention.