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### Instruction:
Do surgically modifiable factors measured by computer-navigation together with patient-specific factors predict knee society score after total knee arthroplasty?
### Response:
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Younger age, better preoperative KSS-F scores and lower BMI before surgery, a positive tibial component slope and small changes in femoral offset were predictors of better KSS-F scores at 4-years.
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### Instruction:
Is fetal exposure to placental corticotropin-releasing hormone associated with child self-reported internalizing symptoms?
### Response:
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Findings suggest that elevated exposures to the feto-placental stress signal pCRH exert programming effects on the developing fetal central nervous system, with lasting consequences for child mental health.
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### Instruction:
Is modified Ideal Cardiovascular Health Status Associated with Lower Prevalence of Stroke in Rural Northeast China?
### Response:
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This study revealed that people with a better CVH status had a lower prevalence of stroke and the susceptibility of stroke increased with the decreasing of the number of ideal CVH metrics.
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### Instruction:
Is detection of pup odors by non-canonical adult vomeronasal neurons expressing an odorant receptor gene influenced by sex and parenting status?
### Response:
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Our results describe, for the first time, a sensory neural population with a specific molecular identity involved in the detection of pup odors. Moreover, it is one of the first reports of a group of sensory neurons the activity of which is sexually dimorphic and depends on social status. Our data suggest that the Olfr692 population is involved in mediating pup-oriented behaviors in mice.
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### Instruction:
Is cognitive impairment in late-life bipolar disorder associated with Alzheimer 's disease pathological signature in the cerebrospinal fluid?
### Response:
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Cognitively impaired patients with BD do not display the so-called AD bio-signature in the CSF. We therefore hypothesize that cognitive deterioration in BD is not associated with the classical pathophysiological mechanisms observed in AD, i.e., amyloid deposition and hyperphosphorylation of microtubule-associated tau protein.
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### Instruction:
Does confirmatory factor analysis of the Infant Feeding style Questionnaire in Latino families?
### Response:
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In a sample of Latino families, pressuring, restrictive, and responsive constructs performed well. The modified IFSQ in both English and Spanish-speaking Latino families may be used to assess parenting behaviors related to early obesity risk in this at-risk population.
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### Instruction:
Does manganese protect against the effects of alcohol on hypothalamic puberty-related hormones?
### Response:
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These results suggest that low level Mn supplementation acts to protect the hypothalamus from some of the detrimental effects of ALC on puberty-related hormones.
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### Instruction:
Does increased Expression of Tripartite Motif ( TRIM ) 47 be a Negative Prognostic Predictor in Human Prostate Cancer?
### Response:
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The results of the present study indicated differential TRIM47 expression levels in human prostate tissues compared to benign tissues. Because high levels of TRIM47 expression were found to be a strong prognostic factor in PC, TRIM47 may represent a novel therapeutic target.
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### Instruction:
Does g protein-coupled receptor 30 regulate trophoblast invasion and its deficiency is associated with preeclampsia?
### Response:
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The present study suggests that GPR30 is a critical regulator of trophoblast cell invasion, and as such may be a potential therapeutic interventional target for preeclampsia and other pregnancy complications resulting from impaired trophoblast invasion.
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### Instruction:
Does tongxinluo reverse the Hypoxia-suppressed Claudin-9 in Cardiac Microvascular Endothelial Cells?
### Response:
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The results manifested that TXL reversed the hypoxia-suppressed claudin-9 by elevating H3K9ac in its gene promoter, playing protective roles in HCMECs.
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### Instruction:
Does ataxia telangiectasia mutated in cardiac fibroblasts regulate doxorubicin-induced cardiotoxicity?
### Response:
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ATM-regulated effects within cardiac fibroblasts are pivotal in Dox-induced cardiotoxicity, and antagonism of ATM and its functions may have potential therapeutic implications.
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### Instruction:
Do the effect of fluctuating maskers on speech understanding of high-performing cochlear implant users?
### Response:
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The detrimental effect of fluctuating maskers on SRTs in CI users shown by prior studies was confirmed by the current study. Concluding, the absence of masking release is mainly caused by the technical and/or physiological properties of CI stimulation, not just the poorer baseline performance of many CI users compared to normal-hearing subjects. Speech understanding in modulated noise was more robust in CI users who had a relatively large electrical dynamic range.
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### Instruction:
Does high urinary albumin/creatinine ratio at admission predict poor functional outcome in patients with acute ischemic stroke?
### Response:
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A high UACR at admission may predict a poor outcome at discharge in patients with acute ischemic stroke.
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### Instruction:
Does waste dump in local communities in developing countries and hidden danger to health?
### Response:
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Industrialisation and urbanisation have brought about a change in the waste that is generated in contemporary communities in developing countries. Therefore, there is the need to embrace speciation and sound management of waste, probably including bioremediation.
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### Instruction:
Is arsenic trioxide-based therapy suitable for patients with psoriasis-associated acute promyelocytic leukemia - A retrospective clinical study?
### Response:
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Psoriasis patients are at high risk for APL. The increased risk is most likely associated with the genetic background and bimolane treatment. The ATO-based therapy is especially suitable for patients with psoriasis-associated APL. Our study also brings a new treatment option for psoriasis.
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### Instruction:
Does fluid consumption and taste novelty determine transcription temporal dynamics in the gustatory cortex?
### Response:
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We demonstrate that in taste learning, transcription programs were activated following the physiological responses (i.e., fluid consumption following a water restriction regime, reward, arousal of the animal, etc.) and the specific information about a given taste (i.e., taste novelty). Moreover, the cortical differential prolonged kinetics of mRNA following novel versus familiar taste learning may represent additional novelty related molecular response, where not only the total amount, but also the temporal dynamics of transcription is modulated by sensory experience of novel information.
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### Instruction:
Is excellent outcome of minimal residual disease-defined low-risk patients sustained with more than 10 years follow-up : results of UK paediatric acute lymphoblastic leukaemia trials 1997-2003?
### Response:
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The excellent outcome for childhood ALL in patients with MRD <0.01% after induction chemotherapy is sustained for more than 10 years from diagnosis. This supports the potential exploration of further reduction of therapy in this group, in an attempt to reduce treatment-related mortality and late effects.
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### Instruction:
Does zinc have insulin-mimetic properties which enhance spinal fusion in a rat model?
### Response:
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This study demonstrates the potential benefit of a locally applied insulin-mimetic agent, such as zinc, in a rat lumbar fusion model. Previous studies have demonstrated the benefits of local insulin application in the same model, and it appears that zinc has similar effects.
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### Instruction:
Do drivers who self-estimate lower blood alcohol concentrations are riskier drivers after drinking?
### Response:
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The tendency to estimate lower BACs could support a series of high-risk decisions, regardless of one's actual BAC. This could include the decision to drive after drinking.
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### Instruction:
Does comparison of Maximum Intercuspal Contacts of Articulated Casts and Virtual cast Requiring Posterior Fixed Partial Dentures?
### Response:
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When there is no posterior antagonist contact following tooth preparation for an FPD, taking a full-arch digital impression and designing the restoration on full-arch virtual models can be advocated.
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### Instruction:
Does systematic data-querying of large pediatric biorepository identify novel Ehlers-Danlos Syndrome variant?
### Response:
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Our work is significant not only because it sheds new light on the pathophysiology of EDS for the affected family and the field at large, but also because it demonstrates the utility of unbiased large-scale clinical recruitment in deciphering the genetic etiology of rare mendelian diseases. With unbiased large-scale clinical recruitment we strive to sequence as many rare mendelian diseases as possible, and this work in EDS serves as a successful proof of concept to that effect.
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### Instruction:
Does artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably suppress Hepatocellular Carcinoma?
### Response:
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All the above observations substantiated by unified computational and in vitro experimental approaches suggested its potential role as a therapeutic anti-cancer agent against HCC.
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### Instruction:
Does surgical Debridement be Superior to Sole Antibiotic Therapy in a Novel Murine Posttraumatic Osteomyelitis Model?
### Response:
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Thus, the animal model presented herein provides a reliable and fascinating tool to study posttraumatic osteomyelitis for clinical therapies.
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### Instruction:
Does macrophage CGI-58 attenuate Inflammatory Responsiveness via Promotion of PPARγ Signaling?
### Response:
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These results demonstrate that macrophage CGI-58 enhances PPARγ signaling and thus suppresses inflammatory responsiveness and mitochondrial dysfunction.
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### Instruction:
Are plasma and intracellular ribavirin concentrations significantly altered by abacavir in hepatitis C virus-infected patients?
### Response:
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Abacavir did not significantly alter ribavirin or ribavirin triphosphate concentrations.
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### Instruction:
Does correction of Midface Depression Using an Inverted m-shaped Expanded Polytetrafluoroethylene Implant improve Gingival Exposure?
### Response:
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For cases involving midface depression, the present technique provides an effective and permanent treatment strategy to improve excessive gingival exposure. This single-step approach is a safe and technically easy therapeutic option which is associated with high patient acceptance.
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### Instruction:
Does active opioid use attenuate the humoral responses to inactivated influenza vaccine?
### Response:
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Our results suggest that opioid use do not significantly alter antibody responses to influenza vaccine supporting the vaccination effort in these populations.
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### Instruction:
Is higher cancer antigen 125 level associated with the presence of permanent atrial fibrillation in systolic heart failure patients?
### Response:
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We have shown that the CA-125 levels can be used to predict AF in patients with systolic HF.
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### Instruction:
Does renal sympathetic denervation improve rate control in patients with symptomatic persistent atrial fibrillation and hypertension?
### Response:
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RSD could improve ventricular HR control in patients with persistent AF. RSD slowed AV node conduction in baseline HR-dependent manner. RSD may become an alternative non-pharmaceutical tool for rate control in patients with persistent AF.
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### Instruction:
Does microRNA-208a potentiate Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like Kinase ( NLK )?
### Response:
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miR-208a can promote Ang II-induced cardiomyocyte apoptosis via negatively regulating NLK expression, and inhibition of miR-208a may provide a novel therapeutic target for cardiomyocyte apoptosis.
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### Instruction:
Do exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice?
### Response:
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Our data suggest that muscle ELVs might have an endocrine effect and could participate in adaptations in beta cell mass during insulin resistance.
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### Instruction:
Do sacrum and Coccyx Radiographs Have Limited Clinical Impact in the Emergency Department?
### Response:
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ED sacrum and coccyx radiographs showed a low positivity rate and had no quantifiable clinical impact. We recommend that sacrum and coccyx radiographs be eliminated from ED practice and patients treated conservatively on the basis of clinical parameters.
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### Instruction:
Does perineal body stretch during labor predict perineal laceration , postpartum incontinence , or postpartum sexual function : a cohort study?
### Response:
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PB stretch during labor is unrelated to perineal laceration, postpartum incontinence, sexual activity, or sexual function.
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### Instruction:
Is the relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation modified by donor smoking and reperfusion hyperoxia?
### Response:
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Plasma levels of lipid peroxidation products are higher in patients with severe PGD, in recipients of lungs from donors with smoke exposure, and in recipients exposed to higher Fio2 at reperfusion. Oxidative injury is an important mechanism of PGD and may be magnified by donor exposure to cigarette smoke and hyperoxia at reperfusion.
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### Instruction:
Do diabetic conditions modulate the adenosine monophosphate-activated protein kinase of podocytes?
### Response:
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We suggest that diabetic conditions induce the relocation and suppression of podocyte AMPKα, which would be a suggestive mechanism in diabetic podocyte injury.
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### Instruction:
Are knee biomechanics during walking in recurrent lateral patellar dislocation normalized by 1 year after medial patellofemoral ligament reconstruction?
### Response:
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Initially, RPD patients had lower knee extension moments during gait compared with controls, but by 1 year after MPFL reconstruction, knee kinematics and kinetics of gait in the RPD patients had returned to normal. These observations indicate that MPFL reconstruction may help to delay prospective knee OA as long as possible by restoring the conformation of the patellofemoral joint and gait biomechanics by surgery.
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### Instruction:
Does computer-assisted navigation decrease the change in the tibial posterior slope angle after closed-wedge high tibial osteotomy?
### Response:
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Computer-assisted CWHTO using four guide pins could avoid inadvertent change in the PSA. The navigation can be used in anticipation of decreasing the risk of change in the PSA in CWHTO, especially in patients whose preoperative PSA is small. The special attention should be paid to locate the hinge axis acutely and to make the parallel proximal and distal osteotomy surfaces during CWHTO.
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### Instruction:
Does influence of mouth rinse on the surface hardness of dental resin nano-composite?
### Response:
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Alcohol containing mouth rinsing solutions have more deleterious effect on hardness of nano composites as compared to alcohol-free mouth rinses.
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### Instruction:
Does supplementation of transport and freezing media with anti-apoptotic drugs improve ovarian cortex survival?
### Response:
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Our results showed that the addition of S1P or Z-VAD-FMK to the transport and freezing media prior to ovarian tissue cryopreservation improves primordial follicular quality and therefore improves global tissue survival. This should ultimately lead to improved fertility restoration after auto-transplantation.
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### Instruction:
Is downregulation of histone H2A and H2B pathways associated with anthracycline sensitivity in breast cancer?
### Response:
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This study revealed a key pathway that contributes to anthracycline resistance and established model systems for investigating drug resistance in all four major breast cancer subtypes. As the histone modification can be targeted with small-molecule inhibitors, it represents a possible means of reversing clinical anthracycline resistance.
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### Instruction:
Is amifampridine phosphate ( Firdapse ( ® ) ) effective and safe in a phase 3 clinical trial in LEMS?
### Response:
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This study provides Class I evidence of efficacy of amifampridine phosphate as a symptomatic treatment for LEMS.
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### Instruction:
Does cocaine-mediated induction of microglial activation involve the ER stress-TLR2 axis?
### Response:
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xThe current study demonstrates that cocaine-mediated activation of microglia involves up-regulation of TLR2 through the ROS-ER stress-ATF4-TLR2 axis. Understanding the mechanism(s) involved in cocaine-mediated up-regulation of ROS-ER stress/TLR2 expression and microglial activation could have implications for the development of potential therapeutic targets aimed at resolving neuroinflammation in cocaine abusers.
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### Instruction:
Does sevoflurane and thiopental preconditioning attenuate the migration and activity of MMP-2 in U87MG glioma cells?
### Response:
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These results suggest that both sevoflurane and thiopental have inhibitory effect on the migration and MMP-2 activity in glioma cells. Thus, it is important that the choice of anesthetics to be used during glioma surgery takes into account their inhibitory properties against the tumor cells.
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### Instruction:
Does soluble receptor for advanced glycation end-products protect against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system?
### Response:
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Our data suggest that the inhibition of sRAGE on I/R-induced apoptosis is associated with activation and expression of proteasome, including improved proteasome activity and elevated β1i and β5i expression mediated by STAT3 activation. We predict that sRAGE is a novel intervention to target UPS activation for preventing and treating myocardial apoptosis.
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### Instruction:
Does gene expression identify heterogeneity of metastatic behavior among gastrointestinal stromal tumors?
### Response:
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Hierarchical clustering using these gene sets identified at least two subsets of GIST with distinct clinical behavior and risk of metastatic disease. The use of gene expression analysis along with other known prognostic factors may better predict the long-term outcome following surgery, and thus restrict the use of adjuvant therapy to high-risk GIST, and reduce heterogeneity among groups in clinical trials of new drugs.
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### Instruction:
Does sulodexide reduce the inflammatory reaction and senescence of endothelial cells in conditions involving chronic venous disease?
### Response:
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Chronic in vitro exposure of HUVEC to medium supplemented with CVD patient serum induces an inflammatory phenotype. Sulodexide treatment significantly reduces that effect and slows HUVEC senescence in the milieu of CVD serum.
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### Instruction:
Does inhibition of p21-Activated Kinase 1 by IPA-3 promote Locomotor Recovery After Spinal Cord Injury in Mice?
### Response:
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Inhibition of PAK1 by IPA-3 promoted recovery of neurological function, possibly by downregulating the expression of MMP-2, MMP-9, TNF-α, and IL-1β. Our data suggest that PAK1 may be a potential therapeutic target in patients with SCI.
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### Instruction:
Does sT2 predict Mortality and Length of Stay in a Critically Ill Noncardiac Intensive Care Unit Population?
### Response:
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ST2 is increased and predictive of prognosis in critically ill patients without primary cardiac disease, suggesting that critically ill patients may often have unrecognized cardiac injury. Clinical decision support algorithms incorporating ST2 and hsTnT results may be useful in patient risk stratification.
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### Instruction:
Does lithium ameliorate LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 Expression?
### Response:
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Lithium can inhibit LPS-induced TLR4 expression and astrocytes activation. These results indicate that lithium plays an important role in astrocytes activation and neuroinflammation-related diseases, which may open new avenues for neuroscience and biomedical research, and also offers new insight into the treatment of POCD.
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### Instruction:
Is apolipoprotein E genotype associated with cognitive impairment in older adults with bipolar disorder?
### Response:
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APOE*4 is not associated with the diagnosis of BD and does not impact the occurrence of dementia in BD. Given the distinct clinical and biological features of cognitive impairment in BD, we hypothesized that dementia in BD is unrelated to AD pathological mechanisms.
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### Instruction:
Does benchmark dose Based on Abnormality of WBC or Micronucleus Frequency in Benzene-Exposed Chinese Workers?
### Response:
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Benchmark dose estimates indicated that BZ exposure at levels below the current occupational exposure standard can induce genotoxicity and hematotoxicity.
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### Instruction:
Do chicken embryonic stem cells and primordial germ cells display different heterochromatic histone marks than their mammalian counterparts?
### Response:
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Chicken ESCs and PGCs differ from their mammalian counterparts with respect to H3K27 methylation. High enrichment of H3K27me3 at PCH is specific to pluripotent cells in chicken. Our results demonstrate that the dynamics in chromatin constitution described during mouse development is not universal to all vertebrate species.
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### Instruction:
Does aging promote Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis?
### Response:
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Our results show that SIRT-3 mediates age-related changes in cartilage redox regulation and protects against early-stage OA. These findings suggest that mitochondrial acetylation promotes OA and that restoration of SIRT-3 in aging cartilage may improve cartilage resistance to oxidative stress by rescuing acetylation-dependent inhibition of SOD2 activity.
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### Instruction:
Does disruption of clathrin-dependent trafficking result in the failure of grass carp reovirus cellular entry?
### Response:
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Our findings suggest that GCRV might enter CIK cells via clathrin-mediated endocytosis in a pH-dependent manner. Additionally, dynamin is critical for efficient viral entry.
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### Instruction:
Does integrative microRNA and gene profiling data analysis reveal novel biomarkers and mechanisms for lung cancer?
### Response:
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Our results demonstrate that integrating miRNAs and target genes are valuable for identifying promising biomarkers, and provided a new insight on underlying mechanism of NSCLC. Further, our well-designed validation studies surely warrant the investigation of the role of target genes related to these 14 miRNAs in the prediction and development of NSCLC.
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### Instruction:
Does cholecystokinin in plasma predict cardiovascular mortality in elderly females?
### Response:
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CCK in plasma is an independent marker of cardiovascular mortality in elderly female patients. The study thus introduces measurement of plasma CCK in gender-specific cardiovascular risk assessment.
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### Instruction:
Does immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury modulate Molecular Outcomes Associated With Early Synovitis?
### Response:
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Early intraarticular immunosuppression mitigated injury-induced increases in collagen fragments, an outcome better predicted by specific marker expression than by histologic measures of synovitis.
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### Instruction:
Do elevated Blood Lead Levels Are Associated with Reduced Risk of Malaria in Beninese Infants?
### Response:
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Our study shows for the first time that BLL are negatively associated with malarial risk considering other risk factors. Malaria is one of the main causes of morbidity and mortality in infants under 5 years worldwide, and lead poisoning is the 6th most important contributor to the global burden of diseases measured in disability adjusted life years (DALYs) according to the Institute of Health Metrics. In conclusion, due to the high prevalence of elevated BLL, health interventions should look forward to minimize the exposure to lead to better protect the population in West Africa.
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### Instruction:
Does selenoprotein T exert an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson 's Disease?
### Response:
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Our findings indicate that selenoproteins such as SelT play a crucial role in the protection of dopaminergic neurons against oxidative stress and cell death, providing insight into the molecular underpinnings of this stress in PD.
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### Instruction:
Is prostate-specific antigen lowering effect of metabolic syndrome influenced by prostate volume?
### Response:
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Prostate-specific antigen levels in patients with metabolic syndrome seem to be lower, and this finding might be affected by the prostate volume.
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### Instruction:
Do therapeutic potential of Polyalthia cerasoides stem bark extracts against oxidative stress and nociception?
### Response:
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The ethyl acetate fraction enriched with flavinoids and steroids from Polyalthia cerasoides stem bark has potent bioactivity to combat inflammation, ROS and pain. This needs further characterization for potential therapeutic applications.
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### Instruction:
Is the Alpha-defensin Test for Periprosthetic Joint Infections Affected by Prior Antibiotic Administration?
### Response:
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The alpha-defensin test maintains its concentration and sensitivity for PJI even in the setting of antibiotic administration. Furthermore, among patients with PJI on antibiotics, the alpha-defensin tests demonstrated a higher sensitivity in detecting PJI when compared with the ESR, CRP, fluid PMN%, and fluid culture. The high sensitivity of the alpha-defensin test, even in the setting of prior antibiotic treatment, provides excellent utility as a screening test for PJI.
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### Instruction:
Does intranasal oxytocin enhance neural processing of monetary reward and loss in post-traumatic stress disorder and traumatized controls?
### Response:
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Oxytocin administration increased reward pathway sensitivity during reward and loss anticipation in PTSD patients and trauma-exposed controls. Thus, oxytocin administration may increase motivation for goal-directed approach behavior in PTSD patients and controls, providing evidence for a neurobiological pathway through which oxytocin could potentially increase motivation and reward sensitivity in PTSD patients.
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### Instruction:
Does early beta-cell dysfunction characterize males with type 2 diabetes of Yemenite origin?
### Response:
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Males with recent-onset diabetes of Yemenite origin have a significant reduction of β-cell function and reduced ability to compensate for insulin resistance compared with diabetic males of non-Yemenite origin. Both males and females of Yemenite origin have a significantly higher maternal inheritance of diabetes. These data suggest different underlying mechanisms leading to early loss of β-cell in diabetic males of Yemenite origin.
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### Instruction:
Does systemic antibiotic therapy significantly improve outcome in a rat model of implant-associated osteomyelitis induced by Methicillin susceptible Staphylococcus aureus?
### Response:
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Systemic perioperative and implant-associated application of antibiotics were both comparably effective to treat implant-associated infections whereas the combined antibiotic therapy further reduced systemic signs of infection time dependent.
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### Instruction:
Is lamina Cribrosa Depth Associated With the Cup-to-Disc Ratio in Eyes With Large Optic Disc Cupping and Cup-to-Disc Ratio Asymmetry?
### Response:
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The LC depth was greater in eyes with generalized increased cupping, as well as in eyes with a higher CDR than fellow eyes, and was significantly related to the CDR. These results suggest that the clinical appearance of cup enlargement or cupping has LC displacement components.
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### Instruction:
Is the Conjunctiva in Normal Tension Glaucoma Patients Thinner Than in Primary Open-Angle Glaucoma Patients : A Comparative Histologic Study?
### Response:
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The conjunctiva in patients with NTG was thinner than in POAG patients. This finding is an additional feature in the pattern of thinner ocular structures in patients with NTG.
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### Instruction:
Are inflammation markers associated with metabolic syndrome and ventricular arrhythmia in patients with coronary artery disease?
### Response:
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WBC, CRP and IL-6 are strongly associated with components of the metabolic syndrome. Their strong association with life-threatening ventricular arrhythmia emphasizes the proarrhythmic role of inflammation in the increased cardiovascular risk of CAD patients.
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### Instruction:
Is cochlear implantation a therapeutic option for superficial siderosis patients with sensorineural hearing loss?
### Response:
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The remarkable improvement in Abbreviated Profile of Hearing Aid Benefit scores shown in this study indicates that cochlear implantation leads to a better quality of life in superficial siderosis patients.
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### Instruction:
Does intravenous Thrombolysis facilitate Successful Recanalization with Stent-Retriever Mechanical Thrombectomy in Middle Cerebral Artery Occlusions?
### Response:
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IVT and thrombus length are predictive factors for a successful recanalization in MT for acute ischemic stroke with underlying MCA occlusion.
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### Instruction:
Does cortical vessel sign on susceptibility weighted imaging reveal clinically relevant hypoperfusion in internal carotid artery stenosis?
### Response:
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In patients with ICA stenosis, asymmetric cortical vessel sign is a sign of clinically relevant hypoperfusion.
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### Instruction:
Does stakeholder attitudes and need regarding cell-free fetal DNA testing?
### Response:
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Stakeholders are positive about the introduction of cell-free fetal DNA testing into clinical practice. They describe both practical and psychological benefits arising from tests that are safe and can potentially be performed earlier in pregnancy. Key concerns, which include the potential for these tests to have a negative impact on informed decision making and increased societal pressure to have testing, can be addressed through careful parent-directed counseling. As applications for these tests expand it is increasingly important to develop innovative approaches to facilitate good understanding for parents who are offered noninvasive prenatal testing.
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### Instruction:
Does hypothermia protect and Prolongs the Tolerance Time of Retinal Ganglion Cells against Ischemia?
### Response:
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Hypothermia protects retinal ganglion cells against ischemia and prolongs their ischemic tolerance time.
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### Instruction:
Does duration of anuria predict recovery of renal function after acute kidney injury requiring continuous renal replacement therapy?
### Response:
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The renal outcome of severe AKI requiring CRRT was poor even in patients without further RRT. Long-term monitoring of renal function is needed, especially in severe AKI patients who are old and have a long duration of anuria.
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### Instruction:
Does aLA-PDT elicit oxidative damage and apoptosis in UVB-induced premature senescence of human skin fibroblasts?
### Response:
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Our study demonstrated that ALA-PDT elicits oxidative damage and apoptosis in photoaged fibroblasts in vitro, which may be the basis for the rejuvenating effects on photoaged skin.
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### Instruction:
Does magnetic resonance imaging reveal the complementary effects of decongestant and Breathe Right Nasal Strips on internal nasal anatomy?
### Response:
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The BRNS alone significantly increases nasal patency and alleviates perceived nasal congestion, and additional relief of symptoms can be obtained with simultaneous use of a decongestant.
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### Instruction:
Does chronic Alcohol Consumption cause Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response?
### Response:
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Our data suggest that dietary high fructose may potentiate chronic alcohol consumption-induced liver injury. The underlying mechanism might be due to the synergistic effect of dietary high fructose and alcohol on the activation of the TLR4 signaling pathway, which in turn leads to KC activation and phenotype switch toward M1 polarization. This study suggests that alcohol-fructose combination contributes to ALD progression.
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### Instruction:
Is serum apolipoprotein E associated with long-term risk of Alzheimer 's disease : The Rotterdam Study?
### Response:
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Serum apoE is associated with long-term risk of Alzheimer's disease in the general population, independent of APOE genotype. Additional predictive value of serum apoE was limited.
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### Instruction:
Does soluble adenylyl cyclase mediate hydrogen peroxide-induced changes in epithelial barrier function?
### Response:
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The data support an important role for prostaglandin activation of sAC and PKA in H2O2-induced barrier disruption.
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### Instruction:
Is tachycardia burden in stroke unit associated with functional outcome after ischemic stroke?
### Response:
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Patients with increased tachycardia burden during stroke unit stay have poor functional outcome. Countermeasures against worsening factors might be utilized for patients with increased tachycardia burden.
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### Instruction:
Does cardiac Valve Noise Reduction by Non-Drug Interventions improve the Sleep Quality of Patients after Mechanical Cardiac Valve Implantation?
### Response:
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Non-drug intervention could improve the sleep quality of patients after mechanical cardiac valve implantation and help the postoperative recovery of the patients. (
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### Instruction:
Does an Experiential Learning Model facilitate Learning of Bedside Ultrasound by Preclinical Medical Students?
### Response:
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An experiential learning model of ultrasound training consisting of brief didactic presentation, practice FAST examinations on normal models, and proctored examinations on patients is an effective way to teach preclinical medical students basic ultrasound skills.
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### Instruction:
Does oxygenated Hypothermic Machine Perfusion After Static Cold Storage improve Hepatobiliary Function of Extended Criteria Donor Livers?
### Response:
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Two hours of oxygenated HMP after traditional SCS restores hepatic ATP levels and improves hepatobiliary function but does not reduce (preexisting) hepatobiliary injury in ECD livers.
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### Instruction:
Does mOLECULAR CHARACTERISATION AND ANTIMICROBIAL RESISTANCE PATTERNS OF ESCHERICHIA COLI isolate FROM GOATS SLAUGHTERED IN PARTS OF KENYA?
### Response:
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This study demonstrated that there is a significant level of antimicrobial resistance in pathogenic E. coli isolated from goat meat from Huruma and Kiserian abattoir. This indicates that goat meat from abattoirs could pose a risk of transmission of pathogenic antibiotic resistant strains to human. Poor hygienic standards and indiscriminate use of antimicrobials are the two main reasons for the presence of resistant pathogens in goat carcasses.
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### Instruction:
Is improvement of oral contraceptive-induced glucose dysregulation and dyslipidemia by valproic acid independent of circulating corticosterone?
### Response:
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The findings in this study suggest that VPA mitigates against the development of COC-induced insulin resistance and dyslipidemia independent of elevated circulating corticosterone.
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### Instruction:
Do omega-3 fatty acids alter P-wave parameters in electrocardiogram or expression of atrial connexins in patients undergoing coronary artery bypass surgery?
### Response:
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Omega-3 polyunsaturated fatty acids supplementation does not alter pro-arrhythmic P-wave parameters in ECG or connexin expression in human atrium with no effect on the incidence of AF following CABG surgery.
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### Instruction:
Is hPV status associated with altered PIWI-interacting RNA expression pattern in head and neck cancer?
### Response:
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The expression of specific piRNAs is deregulated in HNSCC, and changes with both HPV status and type. Importantly, a five-piRNA signature is able to delineate a subset of HPV-positive HNSCC patients with poor outcome, highlighting the potential utility of piRNAs in patient management.
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### Instruction:
Does pulsatilla saponin A induce differentiation in acute myeloid leukemia in vitro?
### Response:
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PsA can modify the differentiation activity of AML cells, probably though the MEK/ERK signaling pathway.
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### Instruction:
Are brief alcohol intervention trials conducted by higher prestige authors and published in higher impact factor journals cited more frequently?
### Response:
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We conclude that studies conducted by more established authors and reported in more prestigious journal outlets are more likely to be cited by other scholars, even after controlling for various proxies of study quality.
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### Instruction:
Do postoperative Respiratory Exercises Reduce the Risk of Developing Pulmonary Complications in Patients Undergoing Lobectomy?
### Response:
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Implementing a postoperative intensive physiotherapy program focused on respiratory exercises reduces the risk of PPCs and resultant LOS on patients undergoing lobectomy.
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### Instruction:
Does oncogenic Gene Fusion FGFR3-TACC3 be Regulated by Tyrosine Phosphorylation?
### Response:
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These results demonstrate that FGFR3 kinase activity is essential for the oncogenic effects of the FGFR3-TACC3 fusion protein and could serve as a therapeutic target, but that phosphorylated tyrosine residues within the TACC3-derived portion are not critical for activity. Mol Cancer Res; 14(5); 458-69. ©2016 AACR.
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### Instruction:
Does biodentine reduce Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells?
### Response:
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In conclusion, this study showed TRPA1 to be modulated by caries-induced inflammation and that Biodentine reduced TRPA1 expression and functional responses.
|
### Instruction:
Is locomotive syndrome associated not only with physical capacity but also degree of depression?
### Response:
|
The results indicate that LS is associated with not only the capacity of physical performance but also the degree of depression although most participants fell under the criteria of LS.
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### Instruction:
Does a prehospital screening tool utilizing end-tidal carbon dioxide predict sepsis and severe sepsis?
### Response:
|
A prehospital screening protocol utilizing SIRS criteria and ETCO2 predicts sepsis and severe sepsis, which could potentially decrease time to therapeutic intervention.
|
### Instruction:
Are body mass index curves for Italian preterm infants comparable with American curves for infants born before 34 weeks of gestational age?
### Response:
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We developed the first European BMI-for-age at birth curves for premature infants. According to our findings, the Italian curves were comparable to the USA curves for the subgroup of infants born at ≤33 gestational weeks, but not ≥34 gestational weeks.
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### Instruction:
Does non-Fontan Adult Congenital Heart Disease Transplantation Survival be Equivalent to Acquired Heart Disease Transplantation Survival?
### Response:
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With careful donor and recipient selection, adults with end-stage CHD undergoing HT can achieve excellent early and midterm survival, comparable to the survival of patients who undergo transplantation for other diagnoses.
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### Instruction:
Does transfusion of sex-mismatched and non-leukocyte-depleted red blood cells in cardiac surgery increase mortality?
### Response:
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In this large retrospective study, transfusion of non-sex-matched RBCs was associated with increased mortality. In addition, in patients receiving small amounts of blood, leukocyte depletion of RBCs had a beneficial effect on patient survival.
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### Instruction:
Do fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice?
### Response:
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F. mume may have therapeutic effects on cognitive impairments in AD.
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### Instruction:
Does high Proportion of Nuclear Phenotype identify Aggressive Cutaneous Squamous Cell Carcinoma?
### Response:
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These data suggest that discriminant functions may be utilized to distinguish between aggressive and nonaggressive lesions at the time of diagnosis.
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### Instruction:
Do serum Osteopontin Levels Correlate with Clinical and Pathological Features in Non-Small Cell Lung Cancer?
### Response:
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Our findings revealed that serum OPN levels strongly correlate with clinical and pathological features in NSCLC patients.
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