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### Instruction: Does comminution play no role in worsening fracture healing of conservatively treated middle third clavicular fractures? ### Response:
Comminution plays no role in worsening fracture healing of conservatively treated middle third clavicular fractures in terms of healing rate, union complications, and union configurations.
### Instruction: Does obesity decrease B cell responses in young and elderly individuals? ### Response:
These results demonstrate that leptin can be responsible for decreased B cell function in obesity.
### Instruction: Is arpin downregulation in breast cancer associated with poor prognosis? ### Response:
Loss of the Arp2/3 inhibitory protein Arpin produces a similar poor outcome in breast cancer as high expression of the NCKAP1 subunit of the Arp2/3 activatory WAVE complex.
### Instruction: Are circulating resistin concentrations independently associated with aortic pulse wave velocity in a community sample? ### Response:
Resistin is independently and directly associated with aortic stiffness and these effects occur beyond BP, insulin resistance, and general inflammation.
### Instruction: Does sodium thiosulfate attenuate glial-mediated neuroinflammation in degenerative neurological diseases? ### Response:
Although NaSH was somewhat more powerful than STS in these in vitro assays, STS has already been approved as an orally available treatment. STS may therefore be a candidate for treating neurodegenerative disorders that have a prominent neuroinflammatory component.
### Instruction: Does fusion cytokine IL-2-GMCSF enhance anticancer immune responses through promoting cell-cell interactions? ### Response:
These results suggested that IL2-GMCSF can efficiently regulate immune responses against tumors. Furthermore, as the bridging effect relies on both IL-2R and GM-CSFR and promotes interactions between immune and tumor cells, IL2-GMCSF may be utilized as a useful tool for dissecting specific immune responses for future clinical applications.
### Instruction: Does health Insurance affect Head and Neck Cancer Treatment Patterns and Outcomes? ### Response:
Uninsured patients and patients with Medicaid are more likely to present with metastatic disease, are more likely to not be treated definitively, and are at a higher risk of HNCSM. The treatment gap between Medicaid and private insurance observed in this study should serve as an immediate policy target for health care reform.
### Instruction: Is spontaneous endogenous pulsatile release of kisspeptin temporally coupled with luteinizing hormone in healthy women? ### Response:
The present study provides evidence supporting the hypothesis that kisspeptin is highly relevant in the regulation and modulation of reproductive functions in humans.
### Instruction: Does globular adiponectin attenuate LPS-induced reactive oxygen species production in HepG2 cells via FoxO3A and HO-1 signaling? ### Response:
These results suggest that gAcrp prevents LPS-induced ROS production and NADPH oxidase activity in HepG2 cells via FoxO3A and HO-1 signaling-dependent mechanisms. The present study demonstrated a suppressive effect of adiponectin on ROS production in liver cells and presented a novel mechanism underlying suppression of ROS production by adiponectin.
### Instruction: Does cardiac shock wave therapy show better outcomes in the coronary artery disease patients in a long term? ### Response:
Following 6 years of follow-up, the CSWT provided agreeable results that improved myocardial function and quality of life in comparing to the month 0 and the control group. These outcomes advise that on a long-term (72 months) CSWT shows better parameters than the control group. These findings highlight that CSWT can improve clinical symptoms, morphology, functions of the heart and quality of life in patients with CHD than the patients just on drug therapy for a long-term.
### Instruction: Is plasma microRNA-21 a potential diagnostic biomarker of acute myocardial infarction? ### Response:
Plasma miR-21 may be a novel biomarker for the diagnosis of AMI. Our study may also provide implications for the development of new biomarkers.
### Instruction: Does rib Fracture Fixation restore Inspiratory Volume and Peak Flow in a Full Thorax Human Cadaveric Breathing Model? ### Response:
Negative pressure inspiration is significantly impaired by an unstable chest wall. Restoring mechanical stability of the fractured ribs improves respiratory outcomes similar to baseline values.
### Instruction: Is heat shock protein 70 a useful marker for predicting colorectal cancer? ### Response:
This study shows that the serum level of HSP70 is elevated in patients with CRC. HSP70 may be utilized as an adjunct to other diagnostic or screening tests.
### Instruction: Are antiproliferative and apoptotic effects of the ethanolic herbal extract of Achillea falcata in human cervical cancer cells mediated via cell cycle arrest and mitochondrial membrane potential loss? ### Response:
Achillea falcata extract induced potent antiproliferative and apoptotic effects in HeLa cells. This was accompanied by cellular shrinkage, chromatin condensation, G2/M phase cell cycle arrest and a loss of mitochondrial membrane potential in these cancer cells.
### Instruction: Do hospitalizations of more than 5 days predict for worse outcomes after radiotherapy for head and neck cancer? ### Response:
As a retrospective review, we report only hypothesis-generating observations, which may have been affected by having incomplete patient information.
### Instruction: Does modified Mandibular Inferior Border Sagittal Split Osteotomy reduce Postoperative Risk for Developing Inferior Border Defects? ### Response:
This study confirms the findings previously reported by our research group that the modified inferior border osteotomy technique in SSO results in a substantial lower frequency of persisting inferior border defects. Surgeons are advised to ensure that the lingual cortex of the inferior border is not included in the split during mandibular advancements, and in cases in which the advancement is more than 10 mm and/or the patient is older than 30 years, surgeons might want to consider using a bone graft or a bone graft substitute.
### Instruction: Is l1CAM an independent predictor of poor survival in endometrial cancer - An analysis of The Cancer Genome Atlas ( TCGA )? ### Response:
L1CAM expression is an independent predictor of poor survival in endometrial cancer, and is associated with advanced stage, high-risk endometrial cancer.
### Instruction: Does intensive Simulation Training in Lower Limb Arterial Duplex Scanning lead to Skills Transfer in Real-World Scenario? ### Response:
Intensive simulation of 3-day training achieved real patient-based assessments that were comparable to MSc students who were 3 months into their traditional training program.
### Instruction: Do dental Student Hand Hygiene Decreased With Increased Clinical Experience? ### Response:
HH effectiveness, attitudes, and practices of dental students decreased as students gained more clinical experience, whereas knowledge did not. Our results suggest that HH instruction should be given throughout the duration of dental students' education.
### Instruction: Is plasma Concentration of the Neurofilament Light Protein ( NFL ) a Biomarker of CNS Injury in HIV Infection : A Cross-Sectional Study? ### Response:
These results show that plasma NFL may prove a valuable tool to evaluate ongoing CNS injury in HIV infection that may be applied in the clinic and in research settings to assess the presence if active CNS injury. Because CSF NFL is also elevated in a variety of other CNS disorders, sensitive measures of plasma NFL may similarly prove useful in other settings.
### Instruction: Does inhibition of protease-activated receptor 4 impair platelet procoagulant activity during thrombus formation in human blood? ### Response:
Background Thrombin-induced platelet activation is important for arterial thrombosis. Thrombin activates human platelets predominantly via protease-activated receptor (PAR)1 and PAR4. PAR1 has higher affinity for thrombin, and the first PAR1 antagonist, vorapaxar, was recently approved for use as an antiplatelet agent. However, vorapaxar is contraindicated in a significant number of patients, owing to adverse bleeding events. Consequently, there is renewed interest in the role of platelet PAR4 in the setting of thrombus formation. Objectives To determine the specific antiplatelet effects of inhibiting PAR4 function during thrombus formation in human whole blood. Methods and Results We developed a rabbit polyclonal antibody against the thrombin cleavage site of PAR4, and showed it to be a highly specific inhibitor of PAR4-mediated platelet function. This function-blocking anti-PAR4 antibody was used to probe for PAR4-dependent platelet functions in human isolated platelets in the absence and presence of concomitant PAR1 inhibition. The anti-PAR4 antibody alone was sufficient to abolish the sustained elevation of cytosolic calcium level and consequent phosphatidylserine exposure induced by thrombin, but did not significantly inhibit integrin αII b β3 activation, α-granule secretion, or aggregation. In accord with these in vitro experiments on isolated platelets, selective inhibition of PAR4, but not of PAR1, impaired thrombin activity (fluorescence resonance energy transfer-based thrombin sensor) and fibrin formation (anti-fibrin antibody) in an ex vivo whole blood flow thrombosis assay. Conclusions These findings demonstrate that PAR4 is required for platelet procoagulant function during thrombus formation in human blood, and suggest PAR4 inhibition as a potential target for the prevention of arterial thrombosis.
### Instruction: Do postpartum Hemorrhage Preparedness Elements Vary Among Hospitals in New Jersey and Georgia? ### Response:
Objective measures of preparedness are needed, because perceptions of preparedness were inconsistent with the number of preparedness elements reported.
### Instruction: Does subclinical neurological involvement develop if Wilson 's disease is treated early? ### Response:
This study suggests that early diagnosis and treatment of WD may prevent the onset of neurologic damage, even at subclinical level.
### Instruction: Is resveratrol equipotent to perindopril in attenuating post-infarct cardiac remodeling and contractile dysfunction in rats? ### Response:
Treatment with resveratrol or perindopril was equivalent in significantly improving remodeling and attenuation of contractile dysfunction in MI rats. Combination treatment also attenuated the cardiac abnormalities. The improvement in cardiac abnormalities may partly be through reducing oxidative stress by preventing the decrease in the activity of superoxide dismutase and catalase, and decreasing cardiac inflammation and fibrosis.
### Instruction: Does vitamin A supplementation modify the antioxidant system in rats? ### Response:
These results indicate that appropriate supplementation of vitamin A might have a beneficial effect on the antioxidant system in rats.
### Instruction: Does oligonol promote anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway? ### Response:
These data demonstrated that oligonol may act as an anti-aging molecule by modulating SIRT1/autophagy/AMPK pathways.
### Instruction: Do c-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections - a prospective study? ### Response:
C-reactive protein and PCT measurement on POD 3 following colorectal cancer resection can positively identify patients at low risk of anastomotic leakage.
### Instruction: Is overcrowding in Psychiatric Wards Associated With Increased Risk of Adverse Incidents? ### Response:
Overoccupancy is prevalent in psychiatric wards and is associated with an increased rate of aggressive AIs and falls. Policy makers should be convinced about the necessity to reduce overcrowding in psychiatric wards and to improve safety of inpatient facilities.
### Instruction: Does selective Intra-procedural AAA sac Embolization During EVAR reduce the Rate of Type II Endoleak? ### Response:
Selective intra-procedural AAA sac embolization in patients with p-MRF is safe and could be an effective method to reduce ELIIp. Further studies are mandatory to support these results at long-term follow up.
### Instruction: Are serum heart type fatty acid binding protein levels changed in hyperthyroidism? ### Response:
Serum H-FABP levels are not altered in patients with hyperthyroidism.
### Instruction: Does beta-arrestin 2 rather than G protein efficacy determine the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands? ### Response:
NOP ligands producing similar effects on NOP/G protein interaction (partial agonism) but showing different effects on β-arrestin 2 recruitment (partial agonism vs antagonism) elicited different actions on anxiety and mood. These results suggest that the action of a NOP ligand on emotional states is better predicted based on its β-arrestin 2 rather than G-protein efficacy.
### Instruction: Does anticlostridial agent 8-hydroxyquinoline improve the isolation of faecal bifidobacteria on modified Wilkins-Chalgren agar with mupirocin? ### Response:
Routine isolation of bifidobacteria from mammalian faeces does not use a reliable selective agar with an anticlostridial agent. Overgrowth of clostridia may result in incorrect estimation of bifidobacterial counts. Thus, in order to improve the selectivity of existing media for bifidobacterial isolation, we chose the modified Wilkins-Chalgren agar with mupirocin and supplemented it with 8-hydroxyquinoline (8HQ), a molecule that shows anticlostridial activity without affecting the growth of bifidobacteria. This newly composed medium showed enhanced selectivity and specificity compared to the original medium and therefore, can be recommended for the isolation of bifidobacteria from mammal faeces.
### Instruction: Does subchronic exposure to static magnetic field differently affect zinc and copper content in murine organs? ### Response:
Subchronic exposure to SMF differently affected copper and zinc content in examined organs, and the changes were more pronounced for the downward oriented field. The outcome could be attributed to the protective, rather than the harmful effect of SMF.
### Instruction: Is caregivers ' Self-Reported Absence of Social Support Networks Related to Treatment Abandonment in Children With Cancer? ### Response:
We found a strong association between the absence of SSN and TxA that was independent of other covariates, including surrogate measures of wealth. Our findings highlight the imperative understanding of social ties and support surrounding children's families for planning strategies to prevent TxA.
### Instruction: Do intrinsic differences between males and females determine sex-specific consequences of inbreeding? ### Response:
These results suggest that females experience stronger selection on genes contributing to reproductive traits. Inbreeding depression in males may be further reduced by sex chromosome hemizygosity, which affects the dominance of some mutations, as well as by the absence of sexual selection. Determining the relative contributions of sex-specific expression, genes on the sex chromosomes, and the environment they are filtered through-including opportunities for sexual selection-may explain the frequent though inconsistent records of sex differences in inbreeding depression, along with their implications for conservation and the evolution of mating systems.
### Instruction: Is incidental findings of uncertain significance : To know or not to know -- that the question? ### Response:
This article investigates how the various arguments for and against a right not to know hold for IFUS. The main investigated arguments are: hypothetical utilitarianism, the right-based argument, the feasibility argument, the value of knowledge argument, the argument from lost significance, the empirical argument, the duty to disclose argument, the avoiding harm argument; the argument from principle, from autonomy, from privacy, as well as the argument from the right to an open future. The analysis shows that both sides in the debate have exaggerated the importance of incidental findings. Opponents of a right not to know have exaggerated the importance of IFUS, while proponents have exaggerated the need to be protected from something that is not knowledge. Hence, to know or not to know is not the question. The question is whether we should be able to stay ignorant of incidental findings of uncertain significance, if we want to. The answer is yes: As long as the information is not accurate and/or actionable: ignorance is bliss. When answering questions that are not asked, we need to think twice.
### Instruction: Is hbA1c significantly associated with arterial stiffness but not with carotid atherosclerosis in a community-based population without type 2 diabetes : The Dong-gu study? ### Response:
High-normal HbA1c level was independently associated with arterial stiffness, but not with carotid atherosclerotic parameters, in the general population without diabetes. Our results suggest that the functional atherosclerotic process may already be accelerated according to HbA1c level, even at a level below the diagnostic threshold for diabetes.
### Instruction: Is the Need for a Step-up in Postoperative Medical Care Predictable in Orthopedic Patients Undergoing Elective Surgery? ### Response:
In an elderly population with multiple comorbidities undergoing elective common major orthopedic procedures, approximately 2% of patients required readmission to the PACU. The most common problems requiring this step-up in care were cardiac and pulmonary, which resulted in an increased length of hospital stay. Patients with OSA and multiple comorbidities undergoing total knee arthroplasty carry an increased risk for postoperative complications.
### Instruction: Does initial Surgical Treatment of Humeral Shaft Fracture predict Difficulty Healing when Humeral Shaft Nonunion Occurs? ### Response:
Humeral shaft nonunions following initial operative fixation of the index fracture is more resistant to achieving union when compared to nonunions forming after initial nonoperative treatment. When final healing is achieved, there is no difference in function or pain.
### Instruction: Do early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve? ### Response:
Electrotonically-triggered EADs are identified as a potential mechanism facilitating intramural reentry in a regionally-ischemic human ventricles model with reduced repolarization reserve.
### Instruction: Does microRNA-361-5p inhibit Cancer Cell Growth by Targeting CXCR6 in Hepatocellular Carcinoma? ### Response:
Our results indicate that miR-361-5p acts as a tumor suppressor and might serve as a novel therapeutic target for the treatment of HCC patients.
### Instruction: Does transfusion of recently donated ( fresh ) red blood cells ( RBCs ) improve survival in comparison with current practice , while safety of the oldest stored units is yet to be established : a meta-analysis? ### Response:
RCTs established that transfusion of 1- to 10-day-old stored RBCs is not superior to current practice. The apparent discrepancy in mortality between analyses of RCTs and observational studies may in part relate to differences in hypotheses tested and ages of stored RBCs studied. Further trials investigating 1- to 10-day-old stored RBC benefits would seem of lower priority than studies to determine whether 4- to 6-week stored units have safety and efficacy equivalent to the 2- to 3-week-old stored RBCs commonly transfused today.
### Instruction: Do clinical characteristics and medication use patterns among hospitalized patients admitted with psychotic vs nonpsychotic major depressive disorder? ### Response:
Several demographic and clinical characteristics differentiate MDD patients with psychosis from those without psychosis in hospital settings that may be helpful in identifying these patients. Comparisons with outpatient samples and treatments implications are discussed.
### Instruction: Does the antiviral compound BIT225 inhibit HIV-1 replication in myeloid dendritic cells? ### Response:
HIV-1 release from MDDC was inhibited by BIT225. This data broadens the drug's antiviral activity profile within cells of the myeloid lineage. These findings suggest a potential role for BIT225 in reducing HIV-1 production and preventing viral dissemination in early and chronic infection and may assist in limiting virus spread with any ongoing viral replication during antiretroviral therapy.
### Instruction: Is iron prioritized to red blood cells over the brain in phlebotomized anemic newborn lambs? ### Response:
Phlebotomy-induced negative iron balance limits iron availability to the developing brain.
### Instruction: Do the relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use? ### Response:
A patient's history of macrolides is a useful predictor of the likelihood of standard triple therapy failure in H. pylori eradication. The alternatives such as a bismuth-based quadruple or a levofloxacin-containing therapy should be considered in patients treated with macrolides for >2 weeks.
### Instruction: Is cerebrospinal fluid lactate associated with multiple sclerosis disease progression? ### Response:
Measurement of CSF lactate may be helpful, in conjunction with other biomarkers of tissue damage, as an early predictor of disease severity in RRMS patients. A better understanding of the alterations of mitochondrial metabolic pathways associated to RRMS severity may pave the way to new therapeutic targets to contrast axonal damage and disease severity.
### Instruction: Does active workstation allow office workers to work efficiently while sitting and exercising moderately? ### Response:
Although moderate intensity exercise performed on cycling workstation during simulated office tasks increases working task execution time with, it has moderate effect size; however, it does not increase the error rate. Participants confirmed that such a working design is suitable for achieving the minimum standards for daily PA during work hours.
### Instruction: Does deletion of Men1 and somatostatin induce hypergastrinemia and gastric carcinoids? ### Response:
Gastric carcinoids require threshold levels of hypergastrinemia, which modulates p27
### Instruction: Does divergent adherence estimate with pharmacokinetic and behavioural measures in the MTN-003 ( VOICE ) study? ### Response:
PK measures indicated similarly low adherence for the oral and vaginal groups. No behavioural measure accurately predicted PK non-adherence. Accurate real-time measures to monitor product adherence are urgently needed.
### Instruction: Is season of diagnosis associated with overall survival in patients with diffuse large B-cell lymphoma but not with Hodgkin 's lymphoma - A population-based Swedish Lymphoma Register study? ### Response:
In summary, season of diagnosis was shown to have impact on overall survival in male patients with DLBCL. Possible explanations of our results are the higher vitamin D level during the summer months, the effects of sunlight on the circadian rhythm and the immune system, or the lower risk of infectious disease during the summer. Further investigations are needed to explore these hypotheses.
### Instruction: Does high NEK2 Expression be a Predictor of Tumor Recurrence in Hepatocellular Carcinoma Patients After Hepatectomy? ### Response:
Overall, these results suggest that NEK2 could be a promising biomarker for HCC recurrence.
### Instruction: Does low-dose paclitaxel ameliorate renal fibrosis by suppressing transforming growth factor-β1-induced plasminogen activator inhibitor-1 signaling? ### Response:
Paclitaxel at low non-cytotoxic doses ameliorates renal fibrosis by inhibiting multiple steps in the TGF-β1-induced PAI-1 signaling including Smads and mitogen-activated protein kinases.
### Instruction: Are rECQ helicases deregulated in hematological malignancies in association with a prognostic value? ### Response:
RECQ helicase expression is deregulated in hematological malignancies compared to their normal counterparts in association with a prognostic value. Deregulation of RECQ helicases appears to play a role in tumorigenesis and represent potent therapeutic targets for synthetic lethal approaches in hematological malignancies.
### Instruction: Is older patient hospital admissions following primary care referral : the truth in the referring? ### Response:
Almost all primary care referrals included the required details as per recent HIQA guidelines. The further inclusion of optional information relating to patient social or functional status, which are of particular relevance to the older population may help patient management.
### Instruction: Does branched-chain amino acid-enriched nutrient increase blood platelet count in patients after endoscopic injection sclerotherapy? ### Response:
EIS induced protein-energy malnutrition, however, skeletal muscle volume was maintained by taking BCAA. Administration of BCAA had some effect in maintaining the nutritional state, and may improve the platelet count. Taking a greater amount of nutrients and shorter dietary restriction period or hospitalization was desirable.
### Instruction: Does exosomal transfer of miR-30a between cardiomyocytes regulate autophagy after hypoxia? ### Response:
miR-30a is highly enriched in exosomes from the serum of AMI patients. Hypoxia induces miR-30a upregulation and enrichment into exosomes. MiR-30a is efficiently transferred via exosomes between hypoxic cardiomyocytes. Inhibition of exosome release contributes to maintaining of autophagy after hypoxia. Inhibition of miR-30a augments autophagy after hypoxia.
### Instruction: Does endurance Exercise improve Molecular Pathways of Aerobic Metabolism in Patients With Myositis? ### Response:
Our data indicate that endurance exercise in patients with established PM and DM may activate an aerobic phenotype and promote muscle growth and simultaneously suppress the inflammatory response in these patients' muscles, as supported by a combination of data on gene expression, proteomics, and capillary density in repeated muscle biopsies.
### Instruction: Does fracture clinic redesign reduce the cost of outpatient orthopaedic trauma care? ### Response:
The virtual fracture clinic system was associated with less overall use of staff resources in comparison to national cost data. Adoption of this system nationally may have the potential to achieve significant cost savings.Cite this article: P. J. Jenkins. Fracture clinic redesign reduces the cost of outpatient orthopaedic trauma care. Bone Joint Res 2016;5:33-36. doi: 10.1302/2046-3758.52.2000506.
### Instruction: Is high dose amoxicillin-based first line regimen equivalent to sequential therapy in the eradication of H. pylori infection? ### Response:
High-dose amoxicillin based eradicating treatment is superior to standard triple therapy and equivalent to sequential therapy; compared to the latter, the shorter duration may represent an advantage.
### Instruction: Is hydrogen Inhalation Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats? ### Response:
Small amounts of inhaled hydrogen were superior to mild hypothermia in improving cardiac function and neurological outcome in this asphyxial rat model of cardiac arrest.
### Instruction: Is sTAT3 Overactivated in Gastric Cancer Stem-Like Cells? ### Response:
The present findings point to STAT3 over activation in GCSLCs. Com- plementary experiments are required to extend the role of STAT3 in stemness fea- tures and invasion properties of GCSCs and to consider the STAT3 pathway for CSC targeted therapy.
### Instruction: Does valsartan attenuate cardiac and renal hypertrophy in rats with experimental cardiorenal syndrome possibly through down-regulating galectin-3 signaling? ### Response:
Up-regulated galectin-3 signaling might also be involved in the pathogenesis in this CRS model. The beneficial effects of valsartan in terms of attenuating cardiac and renal hypertrophy and reducing 24 hours albumin in this model might partly be mediated through down-regulating galectin-3 signal pathway.
### Instruction: Does high-volume hemofiltration combined with early goal-directed therapy improve alveolar-arterial oxygen exchange in patients with refractory septic shock? ### Response:
These findings demonstrated that HVHF, when used as an adjunctive therapy to the EGDP protocol, could improve alveolar-arterial oxygen exchange, clinical outcome and survival in patients with refractory septic shock.
### Instruction: Are upregulation of inflammasome activity and increased gut permeability associated with obesity in children and adolescents? ### Response:
In children and adolescents, obesity is characterized by the activation of the inflammasome and by an alteration of gut permeability. Successful lifestyle modification is effective in reducing inflammation, suggesting that inhibition of the inflammasome may be a potential therapeutic strategy in obesity.
### Instruction: Does percentage-Method improve Properties of Workers ' Sitting- and Walking-Time Questionnaire? ### Response:
The study revealed that the P-method WSWQ had better reliability, validity, and ease of answering than the T-method, suggesting that the P-method can improve properties of the WSWQ and consequently advance the quality of epidemiological surveys in this field.
### Instruction: Are anticancer effects of bishydroxycoumarin mediated through apoptosis induction , cell migration inhibition and cell cycle arrest in human glioma cells? ### Response:
This study provides help to elucidate the translational potential of the in vitro results to be used for further in vivo studies on human glioma using animal or human subjects. The mechanistic pathway studied in this report could be helpful in explaining the mode of action of these classes of natural products.
### Instruction: Is weight loss at the time of diagnosis associated with prognosis in patients with advanced-stage non-small cell lung cancer? ### Response:
Pre-diagnosis weight loss was found to have a negative impact on PFS in patients with NSCLC treated by first-line chemotherapy. Similar studies in larger patient series are warranted.
### Instruction: Does allosteric Modulation of Sigma-1 Receptors elicit Rapid Antidepressant Activity? ### Response:
SOMCL-668, a novel allosteric modulator of sigma-1 receptors, elicits a potent and rapid acting antidepressant effect. The present data provide the first evidence that allosteric modulation of sigma-1 receptors may represent a new approach for antidepressant drug discovery.
### Instruction: Do common and rare CARD14 gene variants affect the antitumour necrosis factor response among patients with psoriasis? ### Response:
The common CARD14 p.Arg820Trp variant might have a significant effect on the response to anti-TNF therapies among patients with psoriasis. In addition, rare CARD14 missense variants could also predispose to a better response.
### Instruction: Do a Multi-Stakeholder Process to Transform a Community-based Screening and Referral Program to Implement Evidence-Based Depression Care? ### Response:
A multi-organization workgroup can benefit from a semi-structured implementation planning procedure because it provides all stakeholders with a shared roadmap for implementation planning.
### Instruction: Does l-Carnosine prevent the Pro-cancerogenic Activity of Senescent Peritoneal Mesothelium Towards Ovarian Cancer Cells? ### Response:
L-carnosine may be a valuable anticancer drug, especially in the context of prevention and therapy of intraperitoneal ovarian cancer metastasis.
### Instruction: Does interleukin-6 trans-signaling induce VEGF synthesis partly via Janus kinases-STAT3 pathway in human mesothelial cells? ### Response:
The present study might provide evidence that high glucose up-regulates IL-6 synthesis in Met-5A cells, to some extent, depending on its osmolality and that IL-6 trans-signaling could induce VEGF synthesis partly dependent on the JAK/STAT3 pathway. This article is protected by copyright. All rights reserved.
### Instruction: Does staging laparoscopy improve treatment decision-making for advanced gastric cancer? ### Response:
Staging laparoscopy can improve treatment decision-making for advanced GC and decrease unnecessary exploratory laparotomy.
### Instruction: Is simple radiographic assessment of bone quality associated with loss of surgical fixation in patients with proximal humeral fractures? ### Response:
Medial cortex ratio is significantly associated with loss of surgical fixation and may prove to be a useful adjunct for clinical decision making in patients with proximal humeral fractures.
### Instruction: Does the traditional Japanese medicine hangeshashinto alleviate oral ulcer-induced pain in a rat model? ### Response:
Hangeshashinto leads to long-lasting analgesic effects, specifically in the ulcer region by destroying the epithelial barrier. Hangeshashinto alleviates oral ulcer-induced pain in inflammation-dependent and/or independent manner.
### Instruction: Is the zebrafish fast myosin light chain mylpfa : H2B-GFP transgene a useful tool for in vivo imaging of myocyte fusion in the vertebrate embryo? ### Response:
Since we know so little about the molecules regulating vertebrate myocyte fusion, we propose that the mylpfa:H2B-GFP transgene will be a very useful reporter for conducting forward and reverse genetic screens to identify new components regulating vertebrate myocyte fusion.
### Instruction: Does rNA interference of cytochrome P450 CYP6F subfamily genes affect susceptibility to different insecticides in Locusta migratoria? ### Response:
Three of the four CYP6F subfamily genes in L. migratoria were associated with the detoxification of deltamethrin or carbaryl. The role of CYPs in insecticide detoxification appears to be both gene and insecticide specific. © 2016 Society of Chemical Industry.
### Instruction: Does irradiation decrease the Neuroendocrine Biomarker Pro-Opiomelanocortin in Small Cell Lung Cancer Cells In Vitro and In Vivo? ### Response:
In summary, POMC biomarker expression and secretion were reduced in SCLC tumours which regrew after irradiation and in repeatedly irradiation (irradiation-primed) cells. Therefore, POMC was no longer predictive of tumour burden. This highlights the importance of fully evaluating biomarkers during and after therapy to assess clinical utility. Furthermore, the gain in mesenchymal characteristics in irradiated cells could be indicative of a more invasive phenotype.
### Instruction: Does interleukin-22 contribute to liver regeneration in mice with concanavalin A-induced hepatitis after hepatectomy? ### Response:
In this study, we demonstrated that IL-22 is a survival factor for hepatocytes and prevents and repairs liver injury by enhancing pro-growth pathways via STAT3 activation. Treatment with IL-22 protein may represent a novel therapeutic strategy for preventing liver injury in patients with liver disease who have undergone hepatectomy.
### Instruction: Does minimizing tacrolimus decrease the risk of new-onset diabetes mellitus after liver transplantation? ### Response:
A minimal TAC regimen can decrease the risk of long-term NODM after LT. Maintaining a cTAC value below 5.89 ng/mL after LT is safe and beneficial.
### Instruction: Does intestine-specific homeobox ( ISX ) induce intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis? ### Response:
ISX expression induced by H. pylori infection may lead to IM and hyperproliferation of gastric mucosa through CDX1/2 and cyclinD1 expression, contributing to gastric carcinogenesis.
### Instruction: Is metformin-induced protection against oxidative stress associated with AKT/mTOR restoration in PC12 cells? ### Response:
Taken together our experimentation supports the hypothesis that Akt/mTOR/S6K cascade may contribute to metformin alleviating effect. The present work while highlighting metformin anti-oxidant characteristics, concludes that Akt/mTOR signaling might be central to the drug's alleviating effects.
### Instruction: Does nOD2 contribute to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and inflammation? ### Response:
NOD2 aggravates myocardial I/R injury by inducing cardiomyocyte apoptosis and inflammation through JNK, p38MAPK and NF-κB signaling pathways. This study provides insight into better understanding the molecular mechanism of NOD2, which may be served as a potential target for the treatment of myocardial I/R injury.
### Instruction: Is expression of 58-kD Microspherule Protein ( MSP58 ) Highly Correlated with PET Imaging of Tumor Malignancy and Cell Proliferation in Glioma Patients? ### Response:
These results indicate that MSP58 plays an important role in cell proliferation and will be one of the potential candidates of molecular therapy targeting proliferation. FLT-PET might be used as an early measure of treatment response in the proliferation-targeted therapy.
### Instruction: Is indices of dietary fat quality during midpregnancy associated with gestational diabetes? ### Response:
The quality of dietary fat during pregnancy is strongly associated with GDM. Randomized clinical trial are needed to confirm these findings.
### Instruction: Is dementia in Parkinson 's disease associated with enhanced mitochondrial complex I deficiency? ### Response:
Patients with PDD have a deficiency in mitochondrial complex I activity and reduced mitochondrial DNA levels in the prefrontal cortex without a change in mitochondrial protein quantity. Therefore, mitochondrial complex I deficiency and reduced mitochondrial DNA in the prefrontal cortex may be a hallmark of dementia in patients with PD.
### Instruction: Does quercetin mitigate valinomycin-induced cellular stress via stress-induced metabolism and cell uptake? ### Response:
This is the first report on the change in metabolism, localization, and accumulation of O-methylated quercetin metabolites in undifferentiated Caco-2 cells as a response during stress caused by valinomycin. These results indicate a potential cellular stress response mechanism in undifferentiated Caco-2 cells, which adds novel insights into the mechanisms of flavonoid cellular bioactivity.
### Instruction: Does bET Bromodomain Blockade mitigate Intimal Hyperplasia in Rat Carotid Arteries? ### Response:
Blocking BET bromodomains mitigates neointima formation, suggesting an epigenetic approach for effective prevention of intimal hyperplasia and associated vascular diseases.
### Instruction: Does pretreatment Gastric Lavage reduce Postoperative Bleeding after Endoscopic Submucosal Dissection for Gastric Neoplasms? ### Response:
Pretreatment gastric lavage reduced postoperative bleeding in patients receiving ESD for gastric neoplasm.
### Instruction: Does the Colonoscopist 's Expertise affect the Characteristics of Detected Polyps? ### Response:
Our study demonstrated that the quality of a colonoscopy, measured by using the PDR, may increase when performed by experienced fellows.
### Instruction: Is increased CSF tau level correlated with decreased lamina cribrosa thickness? ### Response:
An increased CSF level of T-tau was significantly associated with a thinner LCT in both the healthy and AD groups. This result suggests that LCT could serve as a potential non-invasive indicator for increased CSF tau. The clinical meaning of the higher level of CSF T-tau in axonal degeneration of the optic nerve remains to be determined.
### Instruction: Does iL-33 mediate reactive eosinophilopoiesis in response to airborne allergen exposure? ### Response:
These finding suggests that lung IL-33, through innate activation of ILC2s and their production of IL-5, plays a key role in promoting acute reactive eosinophilopoiesis in the bone marrow when naïve animals are exposed to airborne allergens. Therefore, bone marrow eosinophilopoiesis may be affected by atmospheric environmental conditions.
### Instruction: Does far-infrared promote burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy? ### Response:
Far-infrared (FIR) induced autophagy in THP-1 macrophages. FIR suppressed the NLRP3 inflammasome through the activation of autophagy. FIR induced the ubiquitination of ASC by increasing TRAF6. FIR ameliorated burn wound progression and promoted wound healing in a rat burn model.
### Instruction: Try ' I to bother the residents too much ' - the use of capillary blood glucose measurements in nursing homes? ### Response:
Inadequate procedures and training in diabetes care may compromise the rationale for capillary blood glucose measurements in nursing homes, and hence the residents' safety. These concerns should be addressed together with the possibility of involving and empowering residents by exploring their ability and wish to manage their own disease.
### Instruction: Is 5-Hydroxymethylcytosine expression associated with poor survival in cervical squamous cell carcinoma? ### Response:
In cervical squamous cell carcinoma, less aggressive tumor behavior was correlated with 5-hydroxymethylcytosine and TET2. Our data indicated that 5-hydroxymethylcytosine may become a prognostic marker for cervical squamous cell carcinoma and the decreased expression of TET2 may be an underlying mechanism for decreased 5-hmC in cervical squamous cell carcinoma.
### Instruction: Are cRM1 and chromosomal passenger complex component survivin essential to normal mitosis progress and to preserve keratinocytes from mitotic abnormalities? ### Response:
Basal keratinocytes may divide frequently during skin lifespan, and signs of deterioration could appear such as loss of protein factors required for correct mitosis. Our findings suggest that mitotic abnormalities can be prevented by the modulation of CRM1 and survivin. We demonstrated the ability of compound 'IV08.009' to efficiently protect cultured keratinocytes from mitotic abnormalities.
### Instruction: Do myeloid-derived suppressor cells reveal radioprotective properties through arginase-induced l-arginine depletion? ### Response:
Protumor Arg(+) MDSC reveal a unique ability to radioprotect tumor cells through l-arginine depletion, a common mechanism behind both T-cell and macrophage inhibition.
### Instruction: Does comparison of creatinine clearance estimate in subgroups based on Body Mass Index and albumin? ### Response:
CG gave a better prediction of measured CrCl than MDRD in Mediterranean, non-diabetic, non-hospitalized patients although misclassification of patients with regard to renal impairment stage was not present.
### Instruction: Does walking-induced muscle fatigue impair postural control in adolescents with unilateral spastic cerebral palsy? ### Response:
Unlike TD adolescents, treadmill walking for 15 min at their preferred speed lead to significant knee extensor strength losses and impairments in postural control in adolescents with unilateral spastic CP.