question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Is cADA , a novel CD4-targeted HIV inhibitor , synergistic with various anti-HIV drugs in vitro?
### Response:
| Compounds that can specifically downmodulate the CD4 receptor in PBMC have broad-spectrum anti-HIV activity against primary isolates and act synergistically when used in conjunction with currently available antiretroviral drugs. They deserve further study as potential candidate anti-HIV drugs. |
### Instruction:
Do ingestion of casein and whey proteins result in muscle anabolism after resistance exercise?
### Response:
| Acute ingestion of both WH and CS after exercise resulted in similar increases in muscle protein net balance, resulting in net muscle protein synthesis despite different patterns of blood amino acid responses. |
### Instruction:
Is the ventricular epicardial fat related to the myocardial mass in normal , ischemic and hypertrophic hearts?
### Response:
| A constant fat-muscle ratio exists in each ventricle, which is not influenced by ischemia or hypertrophy. Accordingly, during the hypertrophic process, the ventricular fat and the underlying myocardium show a parallel and correlated increase in their masses. |
### Instruction:
Does creatine supplementation decrease total plasma homocysteine in chronic hemodialysis patients?
### Response:
| Creatine supplementation at a rate of 2 g/day does not further decrease tHcy concentrations in chronic dialysis patients already treated with high dose folic acid, vitamin B6, and B12 supplementation. |
### Instruction:
Is localized scleroderma an autoimmune disorder?
### Response:
| Many previous studies conclude that localized scleroderma involves autoimmune abnormalities and is one of the organ-specific autoimmune disorders targeting mainly skin, although the types of autoimmune abnormality are different from systemic sclerosis. |
### Instruction:
Is cardiac injury after subarachnoid hemorrhage independent of the type of aneurysm therapy?
### Response:
| Surgical and endovascular aneurysm therapies were associated with similar risks of cardiac injury and dysfunction after SAH. The presence of neurocardiogenic injury should not affect aneurysm treatment decisions. |
### Instruction:
Is [ Polymorphism of NOS2A promoter -969 ( G > C ) associated with portal hypertension of liver cirrhosis ]?
### Response:
| The polymorphism of NOS2A promoter -969(G>C) is associated with portal hypertension of liver cirrhosis, which results in functional activity increase of NOS2A promoter and is an independent risk factor for portal hypertension. |
### Instruction:
Does [ The mutation V781I in SCN4A gene exist in Chinese patients with normokalemic periodic paralysis ]?
### Response:
| The mutation V781I exists in Chinese patients with normoKPP and may be responsible for normoKPP. |
### Instruction:
Does probenecid interact with the pharmacokinetics of morphine-6-glucuronide in humans?
### Response:
| The active morphine metabolite is subject to transmembrane transport by transporters inhibited by probenecid in humans. |
### Instruction:
Does chronic oral gabapentin reduce elements of central sensitization in human experimental hyperalgesia?
### Response:
| Oral gabapentin, administered to healthy volunteers in a regimen similar to that used in treating chronic neuropathic pain, reduces measures of central sensitization evoked by intradermal capsaicin. This suggests that the pain-relieving effect in chronic neuropathic pain condition is linked to the effect of gabapentin ... |
### Instruction:
Is postdefaecation pain syndrome after circular stapled anopexy abolished by oral nifedipine?
### Response:
| Postdefaecation pain is a specific complication of circular stapled anopexy, affecting a small percentage of patients. Men with a high anal sphincter pressure appear to be at risk. Although the exact aetiology remains unclear, it is likely that rectal rather than anal sphincter muscle is affected. Oral nifedipine repre... |
### Instruction:
Does hypotonic stress activate an intermediate conductance K+ channel in human colonic crypt cells?
### Response:
| The 29 pS K+ channel takes part in volume regulation in human colonic crypt cells. The activation of this channel is mediated through an increase in intracellular Ca2+. |
### Instruction:
Does pantoprazole provide rapid and sustained symptomatic relief in patients treated for erosive oesophagitis?
### Response:
| Pantoprazole is more effective than placebo or nizatidine for controlling heartburn and acid regurgitation in patients with erosive oesophagitis. Relief of GERD symptoms is highly predictive of healing of erosive oesophagitis at 4 and 8 weeks. |
### Instruction:
Is exclusion of HIV epitopes shared with human proteins prerequisite for designing safer AIDS vaccines?
### Response:
| The epitopes shared by HIV and its host are likely to be implicated in the immunopathogenesis of AIDS through induction of cross-reacting effectors of the immune system. The prospect that 'house-keeping' immune mechanism can be foiled by molecular mimicry of HIV with physiologically important human proteins should be t... |
### Instruction:
Is staphylococcal enterotoxin A-induced hepatotoxicity predominantly mediated by Fas ligand ( CD95L )?
### Response:
| These novel findings demonstrate that the mechanisms of hepatic injury in endotoxin-induced and superantigen-induced sepsis are principally different. On one hand, SEA-provoked hepatotoxicity is mediated by FasL and is not associated with leukocyte recruitment. On the other hand, liver damage provoked by LPS is mediate... |
### Instruction:
Does [ Gly374Arg mutation in Fgfr3 cause achondroplasia in mice ]?
### Response:
| The model of Fgfr3-Gly374Arg mutation causing achondroplasia in mice has been established successfully. |
### Instruction:
Does exposure of preimplantation embryos to platelet-activating factor increase birth rate?
### Response:
| Brief exposure of preimplantation stage embryos to PAF will result in a significant increase of delivery rates (pups/litter) as well as birth weights. However, the increase of birth weight was significantly below that found naturally. Additional studies are warranted to elucidate the mechanism of PAF's action in the pr... |
### Instruction:
Do transcranial Doppler emboli count predicts rise in creatinine after coronary artery bypass graft surgery?
### Response:
| Increased numbers of Doppler-detected emboli during coronary artery bypass graft surgery are associated with postoperative renal dysfunction. |
### Instruction:
Does overproduction of BCR-ABL induce apoptosis in imatinib mesylate-resistant cell lines?
### Response:
| Thus, imatinib removal led to apoptosis of BCR-ABL-overexpressing leukemic cells, a phenomenon that could be exploited to sensitize imatinib-resistant cells to the cytotoxic effect of other drugs. |
### Instruction:
Is t-cell function after interleukin-2 therapy in HIV-infected patients correlated with serum cortisol concentrations?
### Response:
| Serum cortisol concentrations are predictive of functional and numerical changes of T cells induced by IL-2 therapy. |
### Instruction:
Are better physician-patient relationships associated with higher reported adherence to antiretroviral therapy in patients with HIV infection?
### Response:
| This study showed that multiple, mutable dimensions of the physician-patient relationship were associated with medication adherence in persons with HIV infection, suggesting that physician-patient relationship quality is a potentially important point of intervention to improve patients' medication adherence. In additio... |
### Instruction:
Are patient-reported and physician-estimated adherence to HAART : social and clinic center-related factors associated with discordance?
### Response:
| Physicians did not correctly estimate patient-reported adherence to HAART in more than one third of patients. Both social variables and factors related to the clinical center were important predictors of discordance between patients and physicians. Interventions to enhance adherence should include strategies addressed ... |
### Instruction:
Is immunodominant PstS1 antigen of mycobacterium tuberculosis a potent biological response modifier for the treatment of bladder cancer?
### Response:
| Our results demonstrate profound in vitro activation of human immune cells by recombinant PstS1. In addition, intravesical PstS1 immunotherapy induced strong local and systemic immune responses together with substantial anti-tumor activity in a preclinical mouse model. Thus, we have identified recombinant PstS1 antigen... |
### Instruction:
Does detailed FISH analysis of day 5 human embryos reveal the mechanisms leading to mosaic aneuploidy?
### Response:
| Post-zygotic chromosome loss was the most common mechanism leading to aneuploidy mosaicism for both groups, followed by chromosome gain, with fewer examples of mitotic non-disjunction. |
### Instruction:
Does postprandial hypertriglyceridemia increase circulating levels of endothelial cell microparticles?
### Response:
| A single high-fat meal led to a significant elevation of plasma EMP levels in healthy, normolipidemic subjects and correlated with a postprandial elevation of serum triglycerides. EMPs may be an indirect marker of endothelial dysfunction or injury induced by postprandial triglyceride-rich lipoproteins. |
### Instruction:
Are paraoxonase-1 gene Leu-Met55 and Gln-Arg192 polymorphisms associated with carotid artery atherosclerosis in a population-based cohort?
### Response:
| The PON1 Leu-Met55 and Gln-Arg192 polymorphisms are not major risk factors for atherosclerosis in the general Caucasian population. |
### Instruction:
Is attenuation of inflammation with short-term dietary intervention associated with a reduction of arterial stiffness in subjects with hypercholesterolaemia?
### Response:
| Short-term low-cholesterol/low-saturated fat diet in hypercholesterolaemia may be effective in improving large artery stiffness, likely through the mitigation of low-grade systemic inflammation. |
### Instruction:
Is a selective approach to histopathology of the gallbladder justifiable?
### Response:
| All cases of gallbladder carcinoma were diagnosed pre-operatively or intra-operatively and a histological diagnosis did not alter the management or outcome of any of these patients. Selective histopathology of the gallbladder is safe and may be a more measured approach saving histolopathology departments time and money... |
### Instruction:
Does peplomycin induce G1-phase specific apoptosis in liver carcinoma cell line Bel-7402 involving G2-phase arrest?
### Response:
| Peplomycin induced G1-phase specific apoptosis in Bel-7402 involving G2-phase arrest. |
### Instruction:
Is the precore mutation associated with severity of liver damage in Brazilian patients with chronic hepatitis B?
### Response:
| Precore mutation was frequent among Brazilian subjects with chronic hepatitis B and its presence was associated with greater severity of liver disease. |
### Instruction:
Does pressure immobilization delays mortality and increase intracompartmental pressure after artificial intramuscular rattlesnake envenomation in a porcine model?
### Response:
| Compared with control animals without treatment, the pressure immobilization group had longer survival, less swelling, and higher intracompartmental pressures after artificial, intramuscular C atrox envenomation in our porcine model. |
### Instruction:
Does richardson score predict short-term adverse respiratory outcomes in newborns > /=34 weeks gestation?
### Response:
| A simple objective score based on routinely collected physiologic predictors can predict respiratory outcomes in infants >/=34 weeks gestation with respiratory distress. |
### Instruction:
Does growth hormone improve mobility and body composition in infants and toddlers with Prader-Willi syndrome?
### Response:
| GH treatment of infants and toddlers with PWS for 12 months significantly improves body composition and when begun before 18 months of age increases mobility skill acquisition. These results suggest that GH therapy instituted early in life may lessen deterioration of body composition in PWS while also accelerating moto... |
### Instruction:
Do aGEs activate mesangial TGF-beta-Smad signaling via an angiotensin II type I receptor interaction?
### Response:
| The present study suggests that AGE-RAGE-mediated ROS generation activates TGF-beta-Smad signaling and subsequently induces mesangial cell hypertrophy and fibronectin synthesis by autocrine production of Ang II. This pathway may provide an important link between metabolic and haemodynamic factors in promoting the devel... |
### Instruction:
Is the apoB/apoA-I ratio better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic lipoproteins and to predict coronary risk?
### Response:
| These results indicate that the apoB/apoA-I ratio is at present the best single lipoprotein-related variable to quantitate coronary risk. Given the additional advantages apolipoproteins possess - fasting samples are not required, apoB/apoA-I is a better index of the adequacy of statin therapy than LDL-C, and the measur... |
### Instruction:
Does integrin beta1 mediate hepatocellular carcinoma cells chemotaxis to laminin?
### Response:
| Integrin beta1 subunit was an important constituent receptor subunit for mediating chemotactic pseudopod protrusion of HCC cell to LN. |
### Instruction:
Do work status and burn specific health after work-related burn injury?
### Response:
| Only a small group of former patients with work-related accidents were not working in the sample studied after a long follow-up period. The unemployed reported more pain and worse perceived health, particularly in psychosocial domains. |
### Instruction:
Does a minor experimental stenosis in porcine descending thoracic aorta affect the spectral content of pressure pulse wave?
### Response:
| A minor experimental constriction located at the level of the descending thoracic aorta increased the spectral content of the pressure pulse wave, indicating that spectral analysis may detect slight flow disturbances before developing remarkable signs of an impaired circulation system. |
### Instruction:
Does high-dose vitamin E supplementation diminish ribavirin-associated haemolysis in hepatitis C treatment with combination standard alpha-interferon and ribavirin?
### Response:
| Vitamin E supplementation alone during standard alpha-interferon and ribavirin therapy does not appear to diminish ribavirin-associated haemolysis. |
### Instruction:
Does anxiety-like state associate with taste to produce conditioned taste aversion?
### Response:
| Taken together, these results indicate that anxiety-like state can serve as the unconditioned stimulus in CTA training. This finding may be relevant to the ontogeny of pathologies involving food aversion. |
### Instruction:
Are diets lower in folic acid and carotenoids associated with the coronary disease epidemic in Central and Eastern Europe?
### Response:
| A diet low in foods containing folate and carotenoids (beta-carotene and lutein/zeaxanthin) may be a major contributing factor to increased coronary risk observed in the countries of Central and Eastern Europe. |
### Instruction:
Are more favorable dietary patterns associated with lower glycemic load in older adults?
### Response:
| Promoting appropriate portions of nutrient-dense carbohydrate foods, particularly whole grain, fruits, vegetables, and dairy foods, may offer reasonable guidance for lowering the glycemic load of the diet among older adults. A lower-glycemic-load diet may reduce the risk for obesity and many chronic diseases. |
### Instruction:
Does self-reported delay in seeking care have poor validity for predicting adverse outcomes?
### Response:
| The inability of self-reported delay to predict adverse outcomes in community-dwelling elderly suggests the need for better understanding and support of the care-seeking process and additional measures of timeliness of access. |
### Instruction:
Is laparoscopic gastric bypass superior to laparoscopic gastric banding for treatment of morbid obesity?
### Response:
| Laparoscopic gastric banding and laparoscopic gastric bypass are feasible and safe. Pouch dilatations after gastric banding are responsible for more late complications compared with the gastric bypass. Laparoscopic gastric bypass offers a significant advantage regarding weight loss and reduction of comorbidities after ... |
### Instruction:
Do prostaglandin FP agonists alter metalloproteinase gene expression in sclera?
### Response:
| PGF(2alpha) and latanoprost acid induce coordinated alterations of MMP gene transcription in scleral organ cultures. These results indicate that PGs can directly trigger MMP gene transcription changes within the sclera. These changes support a role for increased MMPs in the enhancement of uveoscleral outflow that occur... |
### Instruction:
Are caspase-1-deficient mice protected against cisplatin-induced apoptosis and acute tubular necrosis?
### Response:
| These results indicate that caspase-1 contributes to cisplatin-induced ARF and ATN (day 3). Furthermore, caspase-1 affects caspase-3 activation and apoptosis in cisplatin-induced ARF (day 2). |
### Instruction:
Do [ Insulin-like growth factor-II and basic fibroblast growth factor affect periodontal ligament cells expressing osteoprotegerin in vitro ]?
### Response:
| IGF-II enhances the proliferation of PDL cells but prohibits OPG secretion. Although bFGF has the same effect on the proliferation of PDL cells, it has no effect on OPG secretion. Before cytokines were used to enhance periodontal regeneration, their effects on local bone balance should also be studied. |
### Instruction:
Does granulin-epithelin precursor overexpression promote growth and invasion of hepatocellular carcinoma?
### Response:
| GEP is an important factor for HCC growth, invasion, and metastasis. GEP has the potential to serve as a tumor marker and therapeutic target. |
### Instruction:
Does methylenetetrahydrofolate reductase genotype affect risk of relapse after hematopoietic cell transplantation for chronic myelogenous leukemia?
### Response:
| These findings suggest that individuals with the 677CC/1298AA genotype are at higher risk of relapse after hematopoietic cell transplantation and that the balance of intracellular folate metabolites available for nucleotide synthesis (regulated by the relative activity of the MTHFR enzyme) may affect the progression fr... |
### Instruction:
Is maternal protein intake associated with infant blood pressure?
### Response:
| Variation in maternal total protein intake during pregnancy does not appear to program offspring blood pressure. |
### Instruction:
Do measures for preventing early postburn damage improve survival rate of burn patients?
### Response:
| Measures for preventing early postburn damage play an important role in improving the survival rate of burn patients. |
### Instruction:
Do a clinical randomized study on the effects of invasive monitoring on burn shock resuscitation?
### Response:
| Burn shock resuscitation due to the Baxter formula leads to significant hypovolemia during the first 48 h following burn. Haemodynamic monitoring results in more aggressive therapeutic strategies and is associated with a significant increase in fluid administration. Increased crystalloid infusion does not improve prelo... |
### Instruction:
Does [ Expression of human telomerase reverse transcriptase gene in HCC depend on proliferating cell nuclear antigen and P53 ]?
### Response:
| The expression of hTERT gene may relate to the genesis and progression of HCC. There is no significant correlation between the expression of hTERT and PCNA and P53. The detection of hTERT gene expression may be regarded as a marker for recurrence of HCC. |
### Instruction:
Does angiotensin II induce neutrophil accumulation in vivo through generation and release of CXC chemokines?
### Response:
| Ang II provokes rapid neutrophil recruitment, mediated through the release of CXC chemokines such as CINC/KC and MIP-2 in rats and IL-8 in humans, and may contribute to the infiltration of neutrophils observed in acute myocardial infarction. |
### Instruction:
Does toll-like receptor 2 mediate Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart?
### Response:
| These results show for the first time that TLR2 signaling contributes to the loss of myocardial contractility and cytokine production in the heart during S aureus sepsis. |
### Instruction:
Does itaconate reduce visceral fat by inhibiting fructose 2,6-bisphosphate synthesis in rat liver?
### Response:
| These results indicate that itaconate, which is a decarboxylate and resembles phosphoenolpyruvate, is incorporated into liver cells and suppresses glycolysis by decreasing the level of F26BP, resulting in decreased visceral fat. |
### Instruction:
Does rilmenidine prevent blood pressure increase in rats with compromised nitric oxide production?
### Response:
| Rilmenidine has a remarkable role in NO-defective hypertension, possibly by inhibiting central sympathetic outflow and by affecting receptors in vascular smooth muscle also. The prime cause of hypertension in this experimental model--the compromised production of NO due to inhibition of NOS--was not affected by rilmeni... |
### Instruction:
Does centrophenoxine improve chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats?
### Response:
| The abilities of CPH to attenuate memory deficits and neuronal damage after ischemia may be beneficial in cerebrovascular type dementia. |
### Instruction:
Do contextual predictors of mental health service use among children open to child welfare?
### Response:
| Younger children and those remaining in their homes could benefit from increased specialty mental health services. They have disproportionately low rates of service use, despite high levels of need. Increases in interagency coordination may lead to more efficient allocation of service resources to children with the gre... |
### Instruction:
Do altered intracellular sorting signals influence the efficacy of genetic melanoma vaccines incorporating helper determinants in mice?
### Response:
| Altered intracellular sorting signals do not significantly influence the efficacy of genetic melanoma vaccines incorporating helper determinants in our model system. These results further support the concept that linkage of immunogenic helper sequences can be successfully applied for antigen-specific immunotherapy of m... |
### Instruction:
Does lumbar sympathectomy increase blood flow in a dog model of chronic cauda equina compression?
### Response:
| These data suggest that lumbar sympathectomy could induce an increase in blood flow of the compressed cauda equina. As lumbar sympathetic block increases blood flow not only in the lower limbs but also in the cauda equina, it might be evaluated for a conservative treatment of intermittent claudication due to lumbar spi... |
### Instruction:
Do hippocampal volume in adult burn patients with and without posttraumatic stress disorder?
### Response:
| PTSD is not a necessary condition for small hippocampal size in trauma-exposed individuals. Rather, the results provide evidence that smaller hippocampal size in trauma-exposed individuals is a result of traumatic stress. The posttraumatic application of NMDA antagonists may protect against hippocampal damage induced b... |
### Instruction:
Does extracellular calcium antagonize forskolin-induced aquaporin 2 trafficking in collecting duct cells?
### Response:
| Together, these data demonstrate that extracellular calcium, possibly acting through the endogenous CaR, antagonizes forskolin-induced AQP2 translocation to the apical plasma membrane in CD8 cells. In hypercalciuria, this mechanism might blunt water reabsorption and prevent further calcium concentration, thus protectin... |
### Instruction:
Does cCR1 blockade reduce interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome?
### Response:
| Blockade of CCR1 substantially reduced interstitial leukocyte accumulation and the subsequent renal fibrosis in a murine model of nephrotic syndrome and FSGS. These findings support a role for CCR1 in interstitial leukocyte recruitment and suggest that CCR1 blockade might be a new therapeutic strategy in progressive ne... |
### Instruction:
Is a carboxy-terminus motif of HKalpha2 necessary for assembly and function?
### Response:
| The entire carboxy-terminus of HKalpha2 is required for stable assembly with beta1-Na+,K+-ATPase and functionality. |
### Instruction:
Do elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro?
### Response:
| These studies suggest that elevated calcium may stimulate HSMC mineralization by elevating Ca x P product and enhancing the sodium-dependent phosphate cotransporter-dependent mineralization pathway previously observed in HSMCs. |
### Instruction:
Does overexpression of HSP-72 confer cytoprotection in experimental peritoneal dialysis?
### Response:
| Our study therefore shows that the mesothelial stress response confers cytoprotection in experimental peritoneal dialysis, mediated by the induction of HSP-72, and that the stimulus of the pretreatment does not have to be identical to the subsequent injury. These data offer the basis for an attractive novel therapeutic... |
### Instruction:
Does radial artery tonometry demonstrate arterial stiffness in children with type 1 diabetes?
### Response:
| Children with type 1 diabetes have increased arterial stiffness compared with healthy control subjects. Radial artery tonometry is a simple noninvasive technique that could be added to the armamentarium of tests used to provide cardiovascular risk stratification in children with type 1 diabetes. |
### Instruction:
Does tryptase inhibit motility of human spermatozoa mainly by activation of the mitogen-activated protein kinase pathway?
### Response:
| These results indicate that tryptase acts via the ERK1/2 pathway to inhibit motility of human spermatozoa. |
### Instruction:
Do proinflammatory parameters as CRP and IL-6 discriminate between post-PCI cardiac patients with and without exercise-induced ischemia as indicated by Tl-201 myocardial scintigraphy?
### Response:
| We conclude that measurement of these (inflammatory) parameters does not help to delineate post-PCI cardiac patients with and without exercise-induced ischemia. |
### Instruction:
Does foxo3a induce motoneuron death through the Fas pathway in cooperation with JNK?
### Response:
| Therefore, in motoneurons as in other cell types, FOXO transcriptional regulators provide an important link between other signalling pathways and the cell death machinery. |
### Instruction:
Does epileptic activity influence the lateralization of mesiotemporal fMRI activity?
### Response:
| The fMRI lateralization of mesiotemporal visuospatial memory functions in patients with mesiotemporal lobe epilepsy (MTLE) is asymmetric: The larger activation usually appears contralateral to the side of the epileptogenic region. These findings occur more often in MTLE; in patients with extratemporal epilepsy, such ty... |
### Instruction:
Is deregulated cyclin D1 expression associated with decreased efficacy of the selective epidermal growth factor receptor tyrosine kinase inhibitor gefitinib in head and neck squamous cell carcinoma cell lines?
### Response:
| These data suggest that deregulated cyclin D1 overexpression may be associated with resistance of HNSCC to EGFR inhibitors. Therefore, the role of cyclin D1 as a marker of therapeutic response and its utility as a prognostic marker in HNSCC warrant additional analysis. |
### Instruction:
Does microchimerism in immune competent patients related to the leukocyte content of transfused red blood cell concentrate?
### Response:
| This study demonstrates that microchimerism after transfusion does not seem to be dose dependent, and can be induced even by a >3 week old leukoreduced red blood cell concentrate with a very low leukocyte content. |
### Instruction:
Does telomerase prolong the lifespan of normal human ovarian surface epithelial cells without inducing neoplastic phenotype?
### Response:
| We were able to show that the ectopic expression of hTERT in normal human OSE: 1) resulted in cultures with greater growth potential and longer lifespan and 2) did not induce a transformed phenotype previously seen in viral oncogene-transfected OSE cells. The established cell lines would not only provide sufficient mat... |
### Instruction:
Does poly-ADP-ribose polymerase inhibition reduce mesenteric injury after cardiopulmonary bypass?
### Response:
| PARP inhibition prevents CPB-induced mesenteric endothelial dysfunction and tissue damage. |
### Instruction:
Does nonuniform strut distribution correlate with more neointimal hyperplasia after sirolimus-eluting stent implantation?
### Response:
| The number and distribution of stent struts affect the amount of neointima after SES implantation. |
### Instruction:
Is asthma induced by intranasal coadministration of allergen and natural killer T-cell ligand in a mouse model?
### Response:
| These data demonstrate that NKT cells can play crucial roles in allergen sensitization and pathologic states in asthma. Furthermore, our new asthma model using alphaGC will be very useful to induce asthma and to dissect the role of NKT cells and other cells in asthma. |
### Instruction:
Does sociodemographic and symptom correlate of fatigue in an adolescent primary care sample?
### Response:
| Abnormal fatigue is a disabling and prevalent condition in adolescents in primary care. It is associated with a number of additional symptoms, many of which may have viral origins. |
### Instruction:
Do progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model?
### Response:
| Together, these data suggest that P can have antiseizure effects, and these effects may be due in part to actions of its metabolite, 3alpha,5alpha-THP, in the hippocampus. |
### Instruction:
Is chromoendoscopy using indigo carmine dye spraying with magnifying observation the most reliable method for differential diagnosis between non-neoplastic and neoplastic colorectal lesions : a prospective study?
### Response:
| Chromoendoscopy with magnification is the most reliable method for determining whether a colorectal lesion is non-neoplastic or neoplastic. |
### Instruction:
Is over expression of the selectable marker blasticidin S deaminase gene toxic to human keratinocytes and murine BALB/MK cells?
### Response:
| By our study we demonstrated that the expression of bsrm gene is toxic to human keratinocytes and BALB/MK cells. It is likely over expression of BS deaminase gene is responsible for the death. |
### Instruction:
Does the advanced glycation end product pentosidine correlate to IL-6 and other relevant inflammatory markers in rheumatoid arthritis?
### Response:
| The binding of AGE on cell receptors induces activation of nuclear factor kappa B, resulting in enhanced synthesis of proinflammatory cytokines. Moreover, AGE generation may also lead to the formation of new, immunologically relevant epitopes at synovial proteins. Both mechanisms could contribute to initiation and perp... |
### Instruction:
Does sleep deprivation affect thermal pain thresholds but not somatosensory thresholds in healthy volunteers?
### Response:
| The present findings suggest that sleep deprivation produces hyperalgesic changes that cannot be explained by nonspecific alterations in somatosensory functions. |
### Instruction:
Does disc inflammation potentially promote axonal regeneration of dorsal root ganglion neurons innervating lumbar intervertebral disc in rats?
### Response:
| The present results suggest that disc inflammation potentially promotes axonal growth of DRG neurons innervating the disc. In light of the strong correlation between the expression of calcitonin gene-related peptide and nerve growth factor receptor, it is most likely that nerve growth factor-sensitive DRG neurons exten... |
### Instruction:
Is static load repetition a risk factor in the development of lumbar cumulative musculoskeletal disorder?
### Response:
| It was concluded that a cumulative neuromuscular disorder develops because of repetition of static lumbar flexion, and the severity of the disorder provoked is magnified by the number of repetitions. Despite the highly favorable 1:1 work-to-rest ratio and the 7-hour post loading rest period, a full recovery of creep wa... |
### Instruction:
Does modifying center of mass trajectory during sit-to-stand tasks redistribute the mechanical demand across the lower extremity joints?
### Response:
| When changes in initial center of mass position are made, alteration in center of mass horizontal momentum and the orientation of the lower extremity segments relative to the reaction force are observed. Consequently, mechanical demand imposed on the ankle, knee, and hip joint is redistributed. The magnitude of the net... |
### Instruction:
Does granulocyte colony-stimulating factor mobilize functional endothelial progenitor cells in patients with coronary artery disease?
### Response:
| Despite reduced EPCs compared with healthy controls, patients with CAD respond to G-CSF with increases in EPC number and homing receptor expression in the circulation and endothelial out-growth in culture. Endothelial progenitor cells (EPCs) are reduced in coronary artery disease. Granulocyte colony-stimulating factor ... |
### Instruction:
Does ethanol washing attenuate the hypocholesterolemic potential of soy protein?
### Response:
| In this experiment which used identifiable protein preparations, a significant fraction of the cholesterol-lowering effect of SPI in rats was attributed to its protein component but not to the ethanol-extractable minor constituents including isoflavones. |
### Instruction:
Does histidine supplementation suppress food intake and fat accumulation in rats?
### Response:
| Our results indicate that dietary histidine suppresses food intake and fat accumulation in rats. |
### Instruction:
Is postgastrectomy polyneuropathy with thiamine deficiency identical to beriberi neuropathy?
### Response:
| This study showed that thiamine-deficiency neuropathies due to gastrectomy and dietary imbalance are identical despite variability in their clinicopathologic features and suggested that thiamine deficiency can be a major cause of postgastrectomy polyneuropathy. |
### Instruction:
Does methylenetetrahydrofolate reductase polymorphism determine the plasma homocysteine-lowering effect of large-dose folic acid supplementation in patients with cardiovascular disease?
### Response:
| The MTHFR polymorphism may be involved in the total homocysteine-lowering effect of folic acid in patients who have cardiovascular disease. |
### Instruction:
Does hostility differentially predict cardiovascular risk factors in African American and White young adults?
### Response:
| Hostility may confer greater cardiovascular risk among young African Americans than Whites. |
### Instruction:
Does epidermal growth factor receptor tyrosine kinase inhibition repress cyclin D1 in aerodigestive tract cancers?
### Response:
| Taken together, these in vitro and in vivo findings provide direct evidence for repression of cyclin D1 protein as a surrogate marker of response in aerodigestive tract cancers to erlotinib treatment. These findings also provide a rationale for combining an EGFR TKI with an agent that would cooperatively repress cyclin... |
### Instruction:
Does colostrum protein concentrate enhance intestinal adaptation after massive small bowel resection in juvenile pigs?
### Response:
| In an animal model of SBS, CPC supplementation of polymeric infant formula resulted in normal weight gain and features of enhanced morphologic adaptation. |
### Instruction:
Do breast-fed infants have higher leptin values than formula-fed infants in the first four months of life?
### Response:
| The kind of feeding might be a factor affecting serum leptin concentration in term infants. The long-term consequences of this difference between BF and FF infants and leptin's role in promoting obesity later in life are unknown. |
### Instruction:
Does a closed perfusion system with heparin coating and centrifugal pump improve cardiopulmonary bypass biocompatibility in elderly patients?
### Response:
| The results suggest that a closed perfusion system with a heparin-coated circuit and a centrifugal pump may improve cardiopulmonary bypass biocompatibility in elderly cardiac surgery patients in comparison with a conventional system. |
### Instruction:
Is the PlA1/A2 polymorphism of platelet glycoprotein IIIa associated with the risk of type 2 diabetes . The Ludwigshafen Risk and Cardiovascular Health study?
### Response:
| The GPIIIa PlA1/A2 polymorphism is not associated with type 2 diabetes, glucose metabolism, angiographic CHD or myocardial infarction. |
### Instruction:
Does a single nucleotide polymorphism in the MMP-9 promoter affect tumor progression and invasive phenotype of gastric cancer?
### Response:
| Our results indicate that the T allele in the MMP-9 promoter is associated with the invasive phenotype of gastric cancer. |
### Instruction:
Is acute systemic inflammation associated with an increase in peritoneal solute transport rate in chronic peritoneal dialysis patients?
### Response:
| We have shown here that acute systemic inflammation is associated with a temporary increase in PSTR in CPD patients. |
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