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### Instruction:
Is autonomic rectal dysfunction in patients with multiple sclerosis and bowel symptoms secondary to spinal cord disease?
### Response:
| Limitations to this study include the lack of an asymptomatic group with multiple sclerosis and the small sample size to evaluate bowel symptoms. |
### Instruction:
Does collagen remodeling and peripheral immune cell recruitment characterize the cutaneous Langerhans cell histiocytosis microenvironment?
### Response:
| Cutaneous LCH lesions are associated with the peripheral recruitment of a variety of immune cells and are consistently characterized by localized elastosis, collagen damage, and remodeling. |
### Instruction:
Is congenital cytomegalovirus infection associated with high maternal socio-economic status and corresponding low maternal cytomegalovirus seropositivity?
### Response:
| A marked socio-economic gradient in CMV seroprevalence is evident in Australian pregnant women and cases of congenital CMV but not in unselected Australian children. These findings highlight the importance of a community-wide approach to CMV awareness and the potential for hygienic measures to reduce the burden of congenital CMV in Australia. |
### Instruction:
Is misdiagnosis of hemifacial spasm a frequent event in the primary care setting?
### Response:
| Despite its relatively straightforward diagnosis, all patients had an incorrect diagnosis and treatment on their first evaluation. HFS brings social impairment and the delay in adequate treatment negatively impacts QoL. |
### Instruction:
Does down-regulation of phosphoglucose isomerase/autocrine motility factor enhance gensenoside Rh2 pharmacological action on leukemia KG1α cells?
### Response:
| These results suggested that ginsenoside Rh2 suppressed the proliferation of KG1α, the same as down-regulation of PGI/AMF. Down-regulation of PGI/ AMF enhanced the pharmacological effects of ginsenoside Rh2 on KG1α by reducing Akt/mTOR signaling. |
### Instruction:
Is communicating hydrocephalus following eosinophilic meningitis pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia?
### Response:
| Our data showed that pressure by the communicating hydrocephalus as a mechanical factor is the major pathogenic mechanism in chronic VE, most likely triggered by eosinophilic meningitis. There are no signs for an ongoing inflammatory process in chronic VE. The past eosinophilic reaction in VE might be caused by Toxocara ssp. infection and might therefore represent the first hint for an initial cause leading to the development of chronic VE. Our data provide a framework for future studies and potential therapeutic interventions for this enigmatic epidemic neurological disease potentially spreading in Sakha Republic. |
### Instruction:
Does prostaglandin E2 reduce the release and infectivity of new cell-free virions and cell-to-cell HIV-1 transfer?
### Response:
| Our results demonstrate that PGE2, through Epac and Rap activation, alters the transport of newly synthesized HIV-1 components to the assembly site, reducing the release and infectivity of new cell-free virions and cell-to-cell HIV-1 transfer. |
### Instruction:
Are pathogenic variants in TUBB4A found in primary dystonia?
### Response:
| The c.4C>G DYT4 mutation appears to be private, and clinical testing for TUBB4A mutations is not justified in spasmodic dysphonia or other forms of primary dystonia. Moreover, given its allelic association with leukoencephalopathy hypomyelination with atrophy of basal ganglia and cerebellum and protean clinical manifestations (chorea, ataxia, dysarthria, intellectual disability, dysmorphic facial features, and psychiatric disorders), DYT4 should not be categorized as a primary dystonia. |
### Instruction:
Does intrathecal injection of human umbilical cord blood stem cells attenuate spinal cord ischaemic compromise in rats?
### Response:
| Intrathecal transplantation of HUCBSCs is feasible, and it improved spinal cord function, when they were delivered 30 min after spinal cord ischaemia, in a model of endovascular descending thoracic aorta occlusion in rats. Human umbilical cord blood is one of the potentially useful sources of stem cells for therapy of spinal cord ischaemia. |
### Instruction:
Do bacillus Calmette-Guérin and isoniazid preventive therapy protect contacts of patients with tuberculosis?
### Response:
| These findings support the use of IPT in older children and young-adult household contacts, in addition to children younger than 5 years. |
### Instruction:
Are heterogeneous atypical cell populations present in blood of metastatic breast cancer patients?
### Response:
| Metastatic breast cancer patients have atypical cells that are CK + EpCAM - circulating in their blood. Because a substantial number of these patients do not have EpCAM + CTCs, additional studies are needed to evaluate the role of EpCAM - circulating cells as a prognostic and predictive marker. |
### Instruction:
Is cystatin C differentially involved in multiple system atrophy phenotypes?
### Response:
| CysC changes are differentially present in the parkinsonian and cerebellar forms of MSA and may play an important role in the pathogenesis of this neurodegenerative condition. |
### Instruction:
Do computerized self-interviews improve Chlamydia and gonorrhea testing among youth in the emergency department?
### Response:
| Sexually transmitted infection testing in the ED significantly increased during ACASI use and diminished after withdrawal. The ACASI was well accepted by youth and holds promise for enhancing sexually transmitted infection testing in the ED. |
### Instruction:
Is visceral adiposity index ( VAI ) related to the severity of anovulation and other clinical features in women with polycystic ovary syndrome?
### Response:
| Visceral adiposity index is increased in patients with PCOS in concordance with the severity of anovulation, insulin resistance and inflammation. This index could be a very easy and helpful clinical tool in daily practice to predict insulin resistance in women with PCOS. |
### Instruction:
Is presence of intratumoral platelets associated with tumor vessel structure and metastasis?
### Response:
| Our findings demonstrate that platelets within the primary tumor microenvironment play a critical role in the induction of vascular permeability and initiation of tumor metastasis. |
### Instruction:
Does pREPL deficiency with or without cystinuria cause a novel myasthenic syndrome?
### Response:
| Isolated PREPL deficiency is a novel monogenic disorder that causes a congenital myasthenic syndrome with pre- and postsynaptic features and growth hormone deficiency. The myasthenic symptoms in PREPL deficiency with or without cystinuria may respond to pyridostigmine in early life. We attribute the myasthenia to abrogated interaction of PREPL with adaptor protein 1. |
### Instruction:
Does receptor Interacting Protein 2 ( RIP2 ) be Dispensable for OVA-Induced Airway Inflammation in Mice?
### Response:
| Our results suggest that RIP2 is not associated with the development of allergic airway inflammation. |
### Instruction:
Do polymorphisms of ATF6B Are Potentially Associated With FEV1 Decline by Aspirin Provocation in Asthmatics?
### Response:
| Although further functional and replication studies are needed, our preliminary findings suggest that ATF6B may be related to obstructive phenotypes in response to aspirin exposure in adult asthmatics. |
### Instruction:
Is second trimester serum alpha-fetoprotein level a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum?
### Response:
| Our study suggests that AFP levels of the second trimester screening test higher than 1.55 MoM is significantly associated with IUGR in hyperemesis gravidarum. The second trimester screening test can predict poor outcome in HG. |
### Instruction:
Are insulin levels and HOMA index associated with exercise capacity in patients with type 2 diabetes and coronary artery disease?
### Response:
| Insulin resistance, as estimated by fasting insulin and the HOMA index, was inversely associated with exercise capacity in patients with type 2 diabetes and CAD, the association being more pronounced in the subgroup with exercise-induced ischemia. These results indicate that insulin resistance is related to exercise capacity in type 2 diabetic patients with CAD, possibly even more so in patients with exercise-induced ischemia compared to those without. |
### Instruction:
Are early-onset seizures correlated with late-onset seizures in children with arterial ischemic stroke?
### Response:
| Early-onset seizures occurred in 25.6% of children with arterial ischemic stroke. Younger age and cortical involvement were risk factors for early-onset seizures. Sixty-five percent of children with early-onset seizures had late-onset seizures after the acute stage. |
### Instruction:
Does palmitic acid induce autophagy in hepatocytes via JNK2 activation?
### Response:
| JNK1 promotes PA-induced lipoapoptosis, whereas JNK2 activates pro-survival autophagy and inhibits PA lipotoxicity. Our results suggest that modulation of autophagy may have therapeutic benefits in the treatment of lipid-related metabolic diseases. |
### Instruction:
Does icaritin suppress the proliferation of human osteosarcoma cells in vitro by increasing apoptosis and decreasing MMP expression?
### Response:
| Icaritin suppresses the proliferation of SaOS2 human osteosarcoma cells by increasing apoptosis and downregulating MMP expression. |
### Instruction:
Does short-term TNF-alpha inhibition reduce short-term and long-term inflammatory changes post-ischemia/reperfusion in rat intestinal transplantation?
### Response:
| Infliximab significantly reduced both acute IRI and, as with other TNFα inhibitors, long-term inflammatory responses after rat ITX. TNFα inhibition may help diminish chronic inflammatory long-term effects and avoid chronic allograft enteropathy. |
### Instruction:
Does polysialic acid/neural cell adhesion molecule modulate the formation of ductular reactions in liver injury?
### Response:
| PolySia modification of NCAM+ ductules weakens cell-cell and cell-matrix interactions, allowing DRs/HPCs to migrate for normal development and regeneration. Modulation of polySia levels may provide a therapeutic option in liver regeneration. |
### Instruction:
Do calcium phosphate particulates increase friction in the rat knee joint?
### Response:
| The increased joint friction with BCP particulates suggests BCPs may play a role in articular surface degradation and OA development. |
### Instruction:
Does quantification of skeletal metastases in castrate-resistant prostate cancer predict progression-free and overall survival?
### Response:
| Dichotomising patients with CRPC into cohorts with 1-4 or ≥5 skeletal metastases identifies a better and a worse cohort in a manner that is easy and clinically accessible. This simple method facilitates disease stratification and patient management, enabling clinicians to counsel patients more effectively about long-term outcomes and to help select intervention therapies more effectively. |
### Instruction:
Is obesity associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer?
### Response:
| In a multivariate analysis, obesity and optimal tumor cytoreduction were significant predictors of OS. However, obesity was not associated with worse disease-specific survival, suggesting that mortality of obese patients with LGSC may result from other comorbidities. Interventions addressing obesity may improve survival for women diagnosed with LGSC, and further study is warranted to address the role of obesity in LGSC. |
### Instruction:
Is invasive adenocarcinoma of the lung associated with the upper lung regions?
### Response:
| Invasive adenocarcinoma of the lung is highly associated with the upper lung regions. This association is not related to smoking, history of COPD, or total emphysema. The regional distribution of invasive adenocarcinoma may be due to V/Q relationships or other local factors. |
### Instruction:
Do acute inflammatory biomarker profiles predict depression risk following moderate to severe traumatic brain injury?
### Response:
| Acute CSF IBR scores show promise for identifying individuals at risk for PTD. Further research should assess acute CSF inflammatory biomarkers' relationships to chronic inflammation as a mechanism of PTD and should explore anti-inflammatory treatments for PTD, as well as prevention and screening protocols, and link inflammatory biomarkers to symptom tracking. |
### Instruction:
Does dynamic contrast-enhanced micro-computed tomography correlate with 3-dimensional fluorescence ultramicroscopy in antiangiogenic therapy of breast cancer xenografts?
### Response:
| Noninvasive DCE micro-CT provides valuable physiological information of antiangiogenic drug effect in the intact animal and correlates with ex vivo structural analysis of 3D UM. The combined use of DCE micro-CT with UM constitutes a complementary imaging toolset that can help to enhance our understanding of antiangiogenic drug mechanisms of action in preclinical drug research. |
### Instruction:
Is c5a/C5aR pathway essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression?
### Response:
| These data provide evidence that mouse susceptibility to MHV-3-induced FH may rely on C5a/C5aR interactions, for which ERK1/2 and p38 pathways participate in up-regulating Fgl2 expression. Inhibition of C5a/C5aR interactions is expected to be beneficial in the clinical treatment of FH patients. |
### Instruction:
Is s-adenosylhomocysteine associated with subclinical atherosclerosis and renal function in a cardiovascular low-risk population?
### Response:
| In summary, cardiovascular risk factors, subclinical atherosclerosis and eGFR are more strongly associated with SAH than with homocysteine in apparently healthy subjects. Thus, SAH might represent a more promising target to prevent cardiovascular disease than homocysteine. |
### Instruction:
Do bacterial communities on classroom surfaces vary with human contact?
### Response:
| Our results indicate that human-associated microbial communities can be transferred to indoor surfaces following contact, and that such transmission is possible even when contact is indirect, but that proximity to other surfaces in the classroom does not influence community composition. |
### Instruction:
Does calcium sensing receptor promote cardiac fibroblast proliferation and extracellular matrix secretion?
### Response:
| Our results are the first report that CaR plays an important role in Ca(2+) signaling involved in cardiac fibrosis through the phospholipase C- inositol 3,4,5 phosphate (PLC-IP3) pathway. |
### Instruction:
Are polymorphisms in the insulin-like growth factor axis associated with gastrointestinal cancer?
### Response:
| The A allele of SNP rs6214 in the IGF-I gene was associated with EAC, and with HNC in women. The GC genotype of rs6898743 in the GHR gene was negatively associated with ESCC. |
### Instruction:
Does acute administration of haloperidol influence 123I-FP-CIT binding to the dopamine transporter?
### Response:
| Changes in synaptic dopamine due to acute haloperidol administration were not detectable with (123)I-FP-CIT. |
### Instruction:
Does hydrogen sulfide accelerate cell cycle progression in oral squamous cell carcinoma cell lines?
### Response:
| H2 S is a potential pro-proliferative factor of human oral SCC cells that accelerates the progression of the SCC cell cycle; thus, H2 S plays a deleterious role in oral SCC cancer development. |
### Instruction:
Do transforming growth factor-β1-induced Treg cells inhibit the absorption of tissue-engineered cartilage caused by endogenous IFN-γ and TNF-α?
### Response:
| CD4(+) T cells led to the absorption of tissue-engineered cartilage through the secretion of endogenous IFN-γ and TNF-α, whose inflammatory functions were concomitantly suppressed by iTreg cells converted from CD4(+) T cells. This study is clinically relevant and adds to our understanding of the mechanism of tissue-engineered cartilage absorption. |
### Instruction:
Is fibrous cartilage of human menisci less shock-absorbing and energy-dissipating than hyaline cartilage?
### Response:
| In dynamic measurements with a spherical indenter, the menisci are much softer and less energy-dissipating than hyaline cartilage. Further, the menisci are stiffer and less energy-dissipating in the middle, intermediate part compared to the meniscal base. In compression, the energy dissipation of meniscus cartilage plays a minor role compared to hyaline cartilage. At high impacts, energy dissipation is less than on low impacts, similar to cartilage. |
### Instruction:
Are heterogeneous nuclear ribonucleoprotein U-like 1 and Poly ( ADP-ribose ) polymerase 1 downregulated in renal cell carcinoma and connected with the prognosis?
### Response:
| Despite the limitations, hnRPUL1 and PARP1 were downregulated in renal cell carcinoma and connected with the prognosis. |
### Instruction:
Is iL-17A elevated in sera of patients with poorly differentiated ovarian papillary serous cystadenocarcinoma?
### Response:
| Elevation of IL-17A in a high percentage of ovarian serous cystadenocarcinoma and lack of this cytokine in healthy individuals makes it a specific candidate in diagnosis, follow up or immunotherapy. |
### Instruction:
Are non-visualized pregnancy losses prognostically important for unexplained recurrent miscarriage?
### Response:
| Non-visualized pregnancy losses contribute negatively to the chance for live birth: each non-visualized pregnancy loss confers a relative risk (RR) for live birth of 0.90 (95% CI 0.83; 0.97), equivalent to the RR conferred by each additional clinical miscarriage. |
### Instruction:
Does resveratrol prevent neuronal apoptosis in an early brain injury model?
### Response:
| Our results show that resveratrol has an antiapoptotic effect in EBI and that resveratrol might act through the PI3K/Akt signaling pathway. |
### Instruction:
Does serum and glucocorticoid-inducible kinase1 increase plasma membrane wt-CFTR in human airway epithelial cells by inhibiting its endocytic retrieval?
### Response:
| This study demonstrates for the first time that SGK1 selectively increases wt-CFTR in the plasma membrane of human airway epithelia cells by inhibiting its endocytic retrieval from the membrane. |
### Instruction:
Do human adipose tissue-derived stromal/stem cells promote migration and early metastasis of triple negative breast cancer xenografts?
### Response:
| Human ASCs derived from abdominal lipoaspirates of two donors stimulated metastasis of MDA-MB-231 breast tumor xenografts to multiple mouse organs. MDA-MB-231 tumors co-injected with ASCs from one donor exhibited partial EMT, expression of MMP-9, and increased angiogenesis. |
### Instruction:
Does urinary neutrophil gelatinase-associated lipocalin predict kidney outcome and death in patients with cirrhosis and bacterial infections?
### Response:
| In patients with cirrhosis and infections, measurement of urinary NGAL at infection diagnosis is useful in predicting important clinical outcomes, specifically persistency and type of AKI, development of a second infection, and 3-month mortality. |
### Instruction:
Is the open latarjet procedure more reliable in terms of shoulder stability than arthroscopic bankart repair?
### Response:
| Patients who had the open Latarjet procedure had less recurrent instability and better Rowe scores over a mean 6-year followup. We now perform isolated arthroscopic Bankart repair for carefully selected patients, including patients with an Instability Severity Index Score of 3 or less. |
### Instruction:
Do cognitive complaints correlate with depression rather than concurrent objective cognitive impairment in the successful aging evaluation baseline sample?
### Response:
| Subjective cognitive complaints are more likely related to symptoms of depression rather than concurrent cognitive impairment in a large cross-section of community-dwelling adults without a formal diagnosis of dementia. |
### Instruction:
Are serum endostatin concentrations higher in men with symptoms of intermittent claudication?
### Response:
| Serum endostatin is raised in older men who have symptoms of intermittent claudication. The role of endostatin in the genesis and outcome of peripheral artery disease requires further investigation. |
### Instruction:
Is secukinumab treatment in rheumatoid arthritis associated with incremental benefit in the clinical outcomes and HRQoL improvements that exceed minimally important thresholds?
### Response:
| Results of this study show considerable agreement between minimal thresholds of improvement established for PROs and clinical outcome measures used in RA treatment studies and provide thresholds to be considered in gauging the importance of a treatment effect that goes beyond what is considered as minimally important for PRO measures. |
### Instruction:
Is a cam deformity gradually acquired during skeletal maturation in adolescent and young male soccer players : a prospective study with minimum 2-year follow-up?
### Response:
| In youth soccer players, cam deformities gradually develop during skeletal maturation and are probably stable from the time of growth plate closure. The formation of a cam deformity might be prevented by adjusting athletic activities during a small period of skeletal growth, which will have a major effect on the prevalence of hip osteoarthritis. |
### Instruction:
Does plasma D-dimer predict short-term poor outcome after acute ischemic stroke?
### Response:
| D-D levels are a useful tool to predict outcome and mortality 90-day after acute ischemic stroke and have a potential to assist clinicians. |
### Instruction:
Do scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsis?
### Response:
| The findings in this study reveal a novel regulatory mechanism of thymocyte apoptosis in sepsis by SR-BI and HDL. |
### Instruction:
Is tumor deposit a poor prognostic indicator for patients who have stage II and III colorectal cancer with fewer than 4 lymph node metastases but not for those with 4 or more?
### Response:
| Our study was a single-institution retrospective study, and the numbers of patients were relatively small to draw firm conclusions. |
### Instruction:
Does selective inhibition of histone deacetylase 6 alter the composition of circulating blood cells in a lethal septic model?
### Response:
| Tubastatin A treatment has significant impact on the composition of circulating blood cells. It increases the number of circulating monocytes and the red blood cell mass in sham-operated animals. In the CLP animals, it increases the monocyte count, decreases the percentage of granulocytes, restores the lymphocyte population, and decreases the granulocyte-to-lymphocyte ratio. These results may explain why Tubastatin A treatment improves survival in the septic models. |
### Instruction:
Do tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients?
### Response:
| Subpopulations of HNSCC display stem cell features that affect patients' tumor control and survival. Evaluating cancer tissue for expression of the proteasome subunit PSMD1 may help identify patients at risk for relapse. |
### Instruction:
Does population analysis of Vibrio parahaemolyticus originating from different geographical regions demonstrate a high genetic diversity?
### Response:
| Our study reveals a high genetic diversity in the analyzed V. parahaemolyticus strain set as well as for geographical strain subsets, with a high proportion of newly discovered alleles and STs. Differences between the subsets were identified. Our data support the postulated population structure of V. parahaemolyticus which follows the 'epidemic' model of clonal expansion. Application of peptide based AA-MLST allowed the identification of reliable relationships between strains. |
### Instruction:
Does [ Vacuum sealing drainage promote experimental pig explosive abdomen wound healing ]?
### Response:
| VSD can effectively control the amount of bacteria in the wound, and reduce the expressions of pro-inflammatory factors such as TNF-α, IL-1 and IL-6 in drainage fluid. VSD also promotes the expressions of growth factors in the wound. |
### Instruction:
Does curcumin attenuate fructose-induced vascular dysfunction of isolated rat thoracic aorta rings?
### Response:
| Fructose strongly increased the contractile response of aortic rings to both phenylephrine and KCl (Emax was increased by 147.3% and 150.5%, respectively) but it did not affect the relaxant response to Ach. Curcumin significantly decreased the hyper responsiveness of arterial rings to both vasopressors (for phenylephrine, Emax decreased from 147.3% in fructose incubated aorta to 81%, and for KCl, Emax decreased from 150.5% in fructose-incubated aorta to 77.24% respectively). Curcumin also reduces the intracellular calcium level (85% reduction in intracellular calcium). A 1400 W was the only agent that potentiates the effect of curcumin. |
### Instruction:
Is fADD upregulated in relapsing remitting multiple sclerosis?
### Response:
| FADD elevation in leukocytes might be interpreted as the molecular equivalent of an elevated general inflammatory activity in RR MS patients compared to other disease courses. FADD elevation in RR MS reinforces the concept that different pathophysiological and immunological processes sustain RR MS and SP or PP MS. |
### Instruction:
Does prolyl-isomerase Pin1 impair trastuzumab sensitivity by up-regulating fatty acid synthase expression?
### Response:
| Pin1-mediated FAS overexpression is a major regulator of trastuzumab-resistant breast cancer growth and survival. |
### Instruction:
Does hydrogen sulfide inhibit formaldehyde-induced endoplasmic reticulum stress in PC12 cells by upregulation of SIRT-1?
### Response:
| These data indicate that H2S exerts its protection against the neurotoxicity of FA through overcoming ER stress via upregulation of SIRT-1. Our findings provide novel insights into the protective mechanisms of H2S against FA-induced neurotoxicity. |
### Instruction:
Are circulating immunoglobulins associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis?
### Response:
| In patients suffering from carotid artery disease, total IgE, total IgG and oxLDL-IgG levels do not associate with plaque mast cell numbers or other vulnerable plaque histopathological characteristics. This study thus does not provide evidence that the immunoglobulins tested in our cohort play a role in intraplaque mast cell activation or grade of atherosclerosis. |
### Instruction:
Does metformin enhance tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma?
### Response:
| The present work shows that metformin and tamoxifen additively inhibited the growth and augmented the apoptosis of ER-positive breast cancer cells. It provides leads for future research on this drug combination for the treatment of ER-positive breast cancer. |
### Instruction:
Is the tumor necrosis factor α ( -308 A/G ) polymorphism associated with cystic fibrosis in Mexican patients?
### Response:
| An analysis of seven genetic variants of four modifier genes showed that one variant, the TNF2 allele, appears to be significantly associated with CF in Mexican patients. |
### Instruction:
Does a whole-grain cereal-based diet lower postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome?
### Response:
| A twelve week whole-grain cereal-based diet, compared to refined cereals, reduced postprandial insulin and triglycerides responses. This finding may have implications for type 2 diabetes risk and cardiovascular disease. |
### Instruction:
Does vasopressin improve survival compared with epinephrine in a neonatal piglet model of asphyxial cardiac arrest?
### Response:
| Vasopressin results in improved survival, lower postresuscitation troponin, and less hemodynamic compromise after CA in newborn piglets. Vasopressin may be a candidate for testing in human neonates. |
### Instruction:
Do syncytiotrophoblast vesicles show altered micro-RNA and haemoglobin content after ex-vivo perfusion of placentas with haemoglobin to mimic preeclampsia?
### Response:
| This study showed that Hb perfusion can alter the micro-RNA content of released STBMs. Of particular interest is the alteration of two placenta specific micro-RNAs; mir-517a and mir-517b. We have also seen that STBMs may function as carriers of Hb into the maternal circulation. |
### Instruction:
Is elevated exhaled nitric oxide in allergen-provoked asthma associated with airway epithelial iNOS?
### Response:
| Higher fractional exhaled nitric oxide concentration among asthmatics is associated with elevated iNOS mRNA in the bronchial epithelium. Furthermore, our data demonstrates for the first time increased expression and activity of iNOS in the bronchial epithelium after allergen provocation, and thus provide a mechanistic explanation for elevated fractional exhaled nitric oxide in allergen-provoked asthma. |
### Instruction:
Is prehydration effective for rapid control of recalcitrant atopic dermatitis?
### Response:
| Prehydration followed by topical corticosteroid therapy seems to be a highly effective regimen that achieves rapid control of moderate to severe disease. |
### Instruction:
Is the chemokine receptor CXCR4 associated with the staging of gastric cancer?
### Response:
| We present evidence that CXCR4 level is significantly elevated in later stages of gastric cancer. Thus, CXCR4 may play a crucial role in gastric cancer progression. |
### Instruction:
Is impaired left ventricular apical rotation associated with disease activity of psoriatic arthritis?
### Response:
| Subclinical impaired myocardial deformation was common in patients with PsA even without CV risk factors. Apical rotation was associated with the status of PsA disease activity. These new speckle tracking echocardiography techniques can detect subclinical myocardial involvement in PsA. |
### Instruction:
Is high free fatty acid level associated with recurrent stroke in cardioembolic stroke patients?
### Response:
| In this retrospective registry-based observational study, CE stroke seemed to be associated with elevated plasma level of FFA. In addition, the present study suggested that an elevated FFA concentration could be a useful indicator for predicting recurrent stroke in CE stroke patients. |
### Instruction:
Do a comparative study of gold UCLA-type and CAD/CAM titanium implant abutments?
### Response:
| In conclusion, CAD/CAM milled titanium abutment can be fabricated with sufficient accuracy to permit screw joint stability between abutment and fixture comparable to that of the traditional gold cast UCLA abutment. |
### Instruction:
Does anti-miR-197 inhibit migration in HCC cells by targeting KAI 1/CD82?
### Response:
| Taken together, these data suggest that anti-miR-197 suppresses HCC migration and invasion by targeting CD82. The regulation of the miR-197/CD82 axis could be a novel therapeutic target in future HCC effective therapy. |
### Instruction:
Do pPARγ agonists regulate tobacco smoke-induced Toll like receptor 4 expression in alveolar macrophages?
### Response:
| These results suggest that PPARγ agonists regulate inflammation in alveolar macrophages and may play a role in inflammatory diseases such as COPD. |
### Instruction:
Do α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets?
### Response:
| The quality of the intrathecal cellular antiviral response under conditions of impaired VLA-4 function jeopardizes host protection. Our functional in vivo data extend our mechanistic understanding of anti-viral immunity in the CNS and help to estimate the risk potential of upcoming therapeutic agents that target the trafficking of immune cells into distinct anatomical compartments. |
### Instruction:
Is clock gene Bmal1 dispensable for intrinsic properties of murine hematopoietic stem cells?
### Response:
| This paper discusses the necessity of circadian rhythms for HSC functions. Our data clearly shows that a key circadian clock gene Bmal1 is dispensable for intrinsic functions of HSCs, such as differentiation, proliferation and repopulating ability. |
### Instruction:
Is dose always what it seems : where very misleading values can result from volume CT dose index and dose length product?
### Response:
| Radiation dose estimates are more accurate when using the SSDE metric in lieu of the CTDIvol metric for reporting and comparing patient dose indices. |
### Instruction:
Is influence of parafascicular thalamic input on neuronal activity within the nucleus accumbens mediated by nitric oxide - an in vivo study?
### Response:
| This study describes for the first time in vivo extracellular electrical responses of the dNAc on stimulation of the Pfl. Synaptic transmission within the dNAc on stimulation of the Pfl seems to be facilitated by NO. |
### Instruction:
Does endothelin-1 regulate hypoxia-inducible factor-1α and -2α stability through prolyl hydroxylase domain 2 inhibition in human lymphatic endothelial cells?
### Response:
| These results reveal a PHD2-mediated mechanism through which ET-1 stabilizes HIF-1α and HIF-2α pathway thereby regulating LEC behavior and lymphangiogenesis. |
### Instruction:
Are functional Fcgamma receptor polymorphisms associated with human allergy?
### Response:
| FcγRIIA and FcγRIIB functional polymorphisms may have a role in the pathogenesis of allergy. |
### Instruction:
Does p38 Mitogen-activated protein kinase accelerate emphysema in mouse model of chronic obstructive pulmonary disease?
### Response:
| In a new experimental COPD mouse model, p38 accelerates the development of emphysema. |
### Instruction:
Is a banana aquaporin gene , MaPIP1 ; 1 , involved in tolerance to drought and salt stresses?
### Response:
| Our results demonstrated that heterologous expression of banana MaPIP1;1 in Arabidopsis confers salt and drought stress tolerances by reducing membrane injury, improving ion distribution and maintaining osmotic balance. |
### Instruction:
Does l-carnosine alter some hemorheologic and lipid peroxidation parameters in nephrectomized rats?
### Response:
| We found that carnosine has beneficial effects on CKD in terms of lipid peroxidation and RBC deformability. Carnosine may have a healing effect in microcirculation level, but may not have any effect on systemic blood pressure in CKD-induced rats. |
### Instruction:
Is uniPR129 a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations?
### Response:
| The discovery of UniPR129 represents not only a major advance in potency compared with the existing Eph-ephrin antagonists but also an improvement in terms of cytotoxicity, making this molecule a useful pharmacological tool and a promising lead compound. |
### Instruction:
Are patients With First-Episode Psychosis a Homogeneous Population : Implications for Treatment?
### Response:
| The findings of this study need replication in larger samples and on a wider severity scale. Nevertheless, the heterogeneity of patients with FEP might impact on treatment. Policymakers should recognize the importance of the diagnostic and outcome assessment in the treatment of severe mental disorders. |
### Instruction:
Is the effect of timing of cardiac catheterization on acute kidney injury after cardiac surgery influenced by the type of operation?
### Response:
| Delaying cardiac surgery beyond 24h of exposure to contrast agents seems to be justified only in patients undergoing valve surgery with concomitant CABG. |
### Instruction:
Is formation of the nitrative DNA lesion 8-nitroguanine associated with asbestos contents in human lung tissues : a pilot study?
### Response:
| This is the first study to demonstrate that 8-nitroG formation is associated with asbestos contents in human lung tissues. This finding raises a possibility that 8-nitroG serves as a biomarker that can be used to evaluate asbestos exposure and carcinogenic risk. |
### Instruction:
Do modulation of visual evoked potentials by high-frequency repetitive transcranial magnetic stimulation in migraineurs?
### Response:
| RTMS reduced habituation only in migraineurs, indicating increased responsivity to rTMS. The magnocellular visual subsystem may be affected interictally, while the parvocellular system may only be affected preictally. |
### Instruction:
Is microRNA-21 a unique signature associated with coronary plaque instability in humans by regulating matrix metalloproteinase-9 via reversion-inducing cysteine-rich protein with Kazal motifs?
### Response:
| miR-21 might be a biomarker for plaque instability by suppressing target gene RECK to promote the expression and secretion of MMP-9 in macrophages. |
### Instruction:
Do stro-1-positive BMSCs predict postoperative periprosthetic bone mineral density outcomes in uncemented total hip arthroplasty patients?
### Response:
| Elevated Stro-1+ bone marrow cell profile may be a useful prognostic indicator for uncemented THA patients. |
### Instruction:
Is six weeks of unsupervised Nintendo Wii Fit gaming effective at improving balance in independent older adults?
### Response:
| Six weeks of unsupervised Wii balance training is an effective modality for improving balance in independent older adults. |
### Instruction:
Is management of sacroiliac joint disruption and degenerative sacroiliitis with nonoperative care medical resource-intensive and costly in a United States commercial payer population?
### Response:
| The economic burden of SI joint disruption among privately-insured patients in the US is substantial, highlighting the need for more cost-effective therapies. |
### Instruction:
Does hypoperfusion intensity ratio predict infarct progression and functional outcome in the DEFUSE 2 Cohort?
### Response:
| HIR can be easily assessed on automatically processed perfusion maps and predicts the rate of collateral flow, infarct growth, and clinical outcome. |
### Instruction:
Does information compression exploit patterns of genome composition to discriminate populations and highlight regions of evolutionary interest?
### Response:
| We conclude with a discussion of the implications of CE for a complex systems science view of genome evolution. CE allows one to clearly visualise the evolution of individual genomes and populations through a formal, mathematically-rigorous information space. Overall, CE makes a set of biological predictions, some of which are unique and await functional validation. |
### Instruction:
Do extracts of irradiated mature human tooth crowns contain MMP-20 protein and activity?
### Response:
| MMP-20 is a radiation-resistant component of mature tooth crowns enriched in the dentine-enamel. We speculate that MMP-20 catalyzed degradation of organic matrix at this site could lead to enamel delamination associated with oral cancer radiotherapy. |
### Instruction:
Does pten regulate homeostasis and inflammation-induced migration of myelocytes in zebrafish?
### Response:
| Our data provide in vivo evidence that definitive myelopoiesis in zebrafish is critically regulated by pten via the elevation of cebpa expression. |
### Instruction:
Does a bacterial extract of OM-85 Broncho-Vaxom prevent allergic rhinitis in mice?
### Response:
| Taken together, our data suggested that OM-85 BV is a low-cost alternative candidate to prevent AR with simple oral administration. |
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