question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Is gastric emptying in critically ill patients accelerated by adding cisapride to a standard enteral feeding protocol : results of a prospective , randomized , controlled trial?
### Response:
| The data indicate that gastric emptying in critically ill, sedated, and mechanically ventilated patients can be significantly improved by adding cisapride to a routine enteral feeding protocol. |
### Instruction:
Does subarachnoid bupivacaine blockade decrease midazolam and thiopental hypnotic requirements?
### Response:
| Subarachoid bupivacaine blockade decreases hypnotic requirements for both thiopental and midazolam. The results suggest that the reduction in hypnotic requirements is due to the decrease in afferent input induced by spinal anesthesia. |
### Instruction:
Does continuous positive airway pressure increase heart rate variability in congestive heart failure?
### Response:
| Short-term application of nasal continuous positive airway pressure increases heart rate variability and time and frequency domain indexes of parasympathetic activity without influencing cardiac sympathetic activity. This increase may occur reflexively, through stimulation of pulmonary mechanoreceptor afferents. |
### Instruction:
Does midazolam antagonize fentanyl-mediated analgesia in surgical patients?
### Response:
| Under these clinical conditions, the administration of midazolam, when compared with droperidol, was not associated with signs of any antagonistic or antianalgesic action toward fentanyl-mediated analgesia. |
### Instruction:
Is nitric oxide responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo?
### Response:
| The present investigation demonstrates that NO, but not prostacyclin, is essential for flow-mediated dilatation of large human arteries. Hence, this response can be used as a test for the L-arginine/NO pathway in clinical studies. |
### Instruction:
Is late lumen loss after coronary angioplasty associated with the activation status of circulating phagocytes before treatment?
### Response:
| The results of the present study indicate that activated blood granulocytes prevent luminal renarrowing after PTCA, while activated blood monocytes promote late lumen loss. To validate this new finding, further study in an independent patient group is required. |
### Instruction:
Is methacholine responsiveness associated with O3-induced decreases in FEV1?
### Response:
| Although we were unable to find support for our hypothesis, we found, somewhat surprisingly, that respiratory symptoms were weakly associated or unassociated with FEV1 responses after O3 exposure. This finding implies that individuals may experience adverse effects, ie, respiratory symptoms, without large declines in lung function. Conversely, individuals may suffer large declines in lung function without prominent symptoms and, therefore, may remain in an unhealthy environment despite evidence of toxicity. |
### Instruction:
Does dehydroepiandrosterone sulfate predict cardiovascular death in postmenopausal women . The Rancho Bernardo Study?
### Response:
| Although higher DHEAS levels were associated with several major CVD risk factors, they were unrelated to the risk of fatal CVD in women. |
### Instruction:
Does clinical and treatment correlate of access to Section 8 certificates for homeless mentally ill persons?
### Response:
| The study suggests that it is possible to honor the housing preferences of the majority of homeless persons with severe mental illness if adequate resources are provided. However, staff may view persons who have schizophrenia and more symptoms as needing more supervision than those clients prefer. Homeless mentally ill persons may also take longer than more symptomatic persons to pursue independent living through a Section 8 certificate. |
### Instruction:
Is microscopic salpingitis an etiologic factor of tubal pregnancy with intrauterine devices?
### Response:
| The use of an IUD does not appear to cause tubal pregnancy by the mechanism of tubal inflammation or presence of salpingitis isthmica nodosa. Therefore, other mechanisms by which an IUD might cause ectopic pregnancy should be considered. |
### Instruction:
Does pentoxifylline prevent a decrease in arterial oxygen tension in oleic acid-induced lung injury?
### Response:
| Pentoxifylline is a noteworthy drug that could be a candidate as a therapy to help prevent hypoxemia in lung injuries that share a common mechanism with oleic acid-induced lung injury. |
### Instruction:
Does tCV 116 prevent progressive renal injury in rats with extensive renal mass ablation?
### Response:
| These data show that TCV 116 prevents the development of systemic hypertension, glomerular capillary hypertension, proteinuria and glomerulosclerosis in rats with reduced renal mass. We therefore conclude that the renal protection associated with angiotensin I converting enzyme inhibitors and other pharmacologic blockers of the renin-angiotensin system arises chiefly from blockade of AT1 receptor-mediated hemodynamic effects. |
### Instruction:
Does platelet attachment stimulate endothelial cell regeneration after arterial injury?
### Response:
| Platelets stimulate endothelial regeneration at a rate equal to that observed with the potent endothelial mitogen basic fibroblast growth factor. Because this effect was not demonstrated with the supernatant of aggregated platelets, endothelial regeneration may be dependent on attachment of the platelets to the area of injury. |
### Instruction:
Does knockdown of liver-intestine cadherin decrease BGC823 cell invasiveness and metastasis in vivo?
### Response:
| Our data establish a foundation for future studies of the comprehensive protein expression patterns and effects of CDH17 in GC. |
### Instruction:
Are decreased blood riboflavin levels correlated with defective expression of RFT2 gene in gastric cancer?
### Response:
| Defective expression of RFT2 is associated with the development of GC and this may represent a mechanism underlying the decreased plasma riboflavin levels in GC. |
### Instruction:
Does costs explained by function rather than diagnosis -- result from the SNAC Nordanstig elderly cohort in Sweden?
### Response:
| It is the level of functioning, rather than the presence of a brain disorder diagnosis, which predicts costs. ADLs are better explanatory variables of costs than Mini mental state examination. Most people in a population-based cohort are zero users of care. |
### Instruction:
Does overexpression of miR-92a correlate with tumor metastasis and poor prognosis in patients with colorectal cancer?
### Response:
| This study revealed that miR-92a overexpression was correlated with specific colorectal cancer biopathologic features, such as TNM stage, lymph node and distant metastases, and poor survival of the patients, indicating that miR-92a may serve as a molecular prognostic marker for colorectal cancer and disease progression. |
### Instruction:
Does ezetimibe inhibit lymphatic transport of esterified cholesterol but not free cholesterol in thoracic lymph duct-cannulated rats?
### Response:
| This is the first direct evidence that ezetimibe inhibits esterified but not free cholesterol lymphatic transport in thoracic duct-cannulated rats. The results also indicate that ezetimibe is not involved in the lymphatic transport of triacylglycerols, phospholipids, or α-tocopherol. |
### Instruction:
Do prevalence of mood and substance use disorders among patients seeking primary care office-based buprenorphine/naloxone treatment?
### Response:
| Mood and substance use comorbidity is prevalent among patients seeking primary care office-based buprenorphine/naloxone treatment. The findings support the need for clinicians to assess and address these conditions. |
### Instruction:
Does thyroid function influence serum apolipoprotein B-48 levels in patients with thyroid disease?
### Response:
| Increased serum apoB-48 concentrations and CMR may contribute to the increased risk of atherosclerosis and premature coronary artery disease in the hypothyroid state. |
### Instruction:
Does apolipoprotein A-I inhibit CD40 proinflammatory signaling via ATP-binding cassette transporter A1-mediated modulation of lipid raft in macrophages?
### Response:
| ApoA-I suppresses CD40 proinflammatory signaling in macrophages by preventing TRAF-6 translocation to lipid rafts through ABCA1-dependent regulation of free cholesterol (FC) efflux, which may present a novel mechanism of apoA-I-mediated inflammation inhibition in macrophages. |
### Instruction:
Is optic nerve head circulation determined by pulse wave analysis significantly correlated with cardio ankle vascular index , left ventricular diastolic function , and age?
### Response:
| The BOT of the optic nerve head circulation determined by LSFG was significantly correlated with age but was independent of cardiac diastolic function and arterial stiffness. This suggests that the damage to different organs increases with age. Our results confirmed that BOT can be helpful in evaluating physiological aging of the microcirculation. |
### Instruction:
Is small low-density lipoprotein cholesterol concentration a determinant of endothelial dysfunction by peripheral artery tonometry in men?
### Response:
| Small LDL cholesterol concentration was an important, independent determinant of endothelial dysfunction in men. |
### Instruction:
Is angiopoietin-2 a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass?
### Response:
| Collectively, our results suggest that Ang-2 is a putative mediator of endothelial barrier dysfunction after CPB. These findings suggest that targeting the Ang/Tie2 pathway may mitigate organ dysfunction and improve outcome in patients undergoing CPB. |
### Instruction:
Is vitamin D a major determinant of bone mineral density at school age?
### Response:
| Vitamin D insufficiency was common even when vitamin D intake exceeded the recommended daily intake. Vitamin D status was a key determinant of BMD. The findings suggest urgent need to increase vitamin D intake to optimize bone health in children. |
### Instruction:
Do multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds?
### Response:
| These studies suggest nesprins act as highly versatile tissue specific intracellular protein scaffolds and identify potential novel functions for nesprins beyond cytoplasmic-nuclear coupling. These alternate functions may also account for the diverse range of disease phenotypes observed when these genes are mutated. |
### Instruction:
Is elevated homocysteine associated with poorer self-perceived physical health in older men : the Health in Men Study?
### Response:
| Elevated tHcy is associated with poorer self-perceived physical health in community-dwelling older men. The results of this study support further longitudinal investigations to assess this relationship prospectively. |
### Instruction:
Does brain-derived neurotrophic factor Val66Met polymorphism predict worse functional outcome after surgery in patients with unruptured brain arteriovenous malformation?
### Response:
| The Val66Met polymorphism is associated with worsened surgical outcome in patients with unruptured brain arteriovenous malformation, a group that currently has no good risk predictors. Further studies replicating these findings are needed. |
### Instruction:
Does niche-associated activation of rac promote the asymmetric division of Drosophila female germline stem cells?
### Response:
| Thus, the GSCs, an adult stem cell present in a cellular niche, have a niche-associated polarity that couples control of the division plane with increased response to an extracellular maintenance signal. Other processes work in parallel with the Rac-mediated polarity to ensure a robust pattern of asymmetric division. We suggest that all adult stem cells likely employ multiple, independently acting mechanisms to ensure asymmetric division to maintain tissue homeostasis. |
### Instruction:
Does testosterone replacement therapy improve erythrocyte membrane lipid composition in hypogonadal men?
### Response:
| The TRT induced increase of PE content and the reduction of saturation in the PC acyl chains induced alterations in the structure of EM could result in higher flexibility of the erythrocytes. The increase of the SM-metabolizing enzyme neutral sphingomyelinase, which regulates the content of ceramide in membranes has a possible impact on the SM signaling pathway. |
### Instruction:
Does hIV-1 gp120 induce autophagy in cardiomyocytes via the NMDA receptor?
### Response:
| In summary, our research demonstrated for the first time that HIV-1 gp120 could induce autophagy of cardiomyocytes and the NMDA receptor, JNK and class III PI3K were involved in this process. This observation provides a new insight into the mechanisms of in the cardiovascular involvement during HIV-1 infection. |
### Instruction:
Is adipocyte-released insulin-like growth factor-1 regulated by glucose and fatty acids and controls breast cancer cell growth in vitro?
### Response:
| IGF-1 release by adipocytes is regulated by glucose and fatty acids and may contribute to the control of cancer cell growth in obese individuals. |
### Instruction:
Do higher glycosylated hemoglobin levels increase the risk of overactive bladder syndrome in patients with type 2 diabetes mellitus?
### Response:
| Patients with type 2 mellitus present more overactive bladder symptoms/urgency and nocturia than controls. Among diabetic patients, higher glycosylated hemoglobin level represents an independent predictor of overactive bladder /urgency, urge urinary incontinence and nocturia. |
### Instruction:
Is modest increase in peak VO2 related to better clinical outcomes in chronic heart failure patients : results from heart failure and a controlled trial to investigate outcomes of exercise training?
### Response:
| Among patients with chronic systolic heart failure, a modest increase in peak VO(2) over 3 months was associated with a more favorable outcome. Monitoring the change in peak VO(2) for such patients may have benefit in assessing prognosis. |
### Instruction:
Is apolipoprotein E mimetic more effective than apolipoprotein A-I mimetic in reducing lesion formation in older female apo E null mice?
### Response:
| Although both peptides had similar anti-inflammatory properties, Ac-hE18A-NH(2) was more effective in inhibiting lesions than 4F at the same dose, frequency, and route of administration, perhaps due to its cholesterol reducing properties. |
### Instruction:
Does thrombomodulin protect endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling?
### Response:
| TM may be useful for prevention, as well as treatment of endothelial cell damage after hematopoietic stem cell transplantation. |
### Instruction:
Is blood pressure response to exercise exaggerated in normotensive diabetic patients?
### Response:
| SBP response to exercise is exaggerated in normotensive diabetic patients compared with non-diabetic subjects. DM, office SBP and male gender are independent predictors of peak SBP. DM, office SBP and age are independent predictors of HRE. |
### Instruction:
Does tGFβ inhibition during expansion phase increase the chondrogenic re-differentiation capacity of human articular chondrocytes?
### Response:
| TGFβ-depletion during expansion improves the re-differentiation capacity of chondrocytes and inhibits hypertrophy. These results indicate the importance of the expansion medium composition to improve chondrogenic re-differentiation and to inhibit hypertrophy. |
### Instruction:
Is in type 2 diabetes patients , insulin glargine associated with lower postprandial release of intact proinsulin compared with sulfonylurea treatment?
### Response:
| Treatment of T2DM with GLA plus MET or DPP-4-I plus MET was associated with a more physiological postprandial secretion pattern of the β cell compared with those treated with SU plus MET. |
### Instruction:
Is ischemia change in stable coronary artery disease an independent predictor of death and myocardial infarction?
### Response:
| In stable CAD, ischemia worsening is an independent predictor of death or MI, resulting in significantly improved risk reclassification when added to previously known predictors. |
### Instruction:
Are b-type natriuretic peptide levels correlated with birth-weight discordance in monochorionic-diamniotic twins without twin-twin transfusion syndrome?
### Response:
| Cardiac dysfunction occurs in both larger and smaller co-twins with increasing birth-weight discordances, even in the absence of TTTS. |
### Instruction:
Does insulin at normal physiological levels prolong QT ( c ) interval in thorough QT studies performed in healthy volunteers?
### Response:
| The findings of this study demonstrate that there was no change in QT(c) during the euglycaemic clamp. Given that insulin was raised to physiological concentrations comparable with those seen after a meal, whilst the release of C-peptide was suppressed, insulin appears to have no effect on the QT(c) interval in either direction. The results suggest a relationship exists between the shortening of QT(c) and C-peptide concentrations and indicate that glucose may have a QT(c) prolonging effect, which will require further research. |
### Instruction:
Is lINE-1 hypomethylation in noncancerous esophageal mucosae associated with smoking history?
### Response:
| A history of tobacco use was significantly associated with LINE-1 hypomethylation in noncancerous esophageal mucosae of ESCC patients. These results support the potential of LINE-1 methylation level as an indicator of epigenetic field for ESCC cancerization, particularly when caused by tobacco smoking. |
### Instruction:
Is non-dipping pattern in untreated hypertensive patients related to increased pulse wave velocity independent of raised nocturnal blood pressure?
### Response:
| Our results suggest that diminished nocturnal decline in BP is independently associated with PWV and nocturnal BP rather than daytime BP. Non-dipper pattern, mainly related to increased PWV and impaired modulation of vascular smooth muscle tone during the night, may justify an increased cardiovascular risk in these patients. |
### Instruction:
Do evaluation of arterial waveform derived variables for an assessment of volume resuscitation in mechanically ventilated burn patients?
### Response:
| Our results suggest that measurement of stroke volume variations by arterial pulse contour analysis is valuable in monitoring volume administration and in predicting volume responsiveness during the early postburn period. |
### Instruction:
Is p50 sensory gating a trait marker of the bipolar spectrum?
### Response:
| The findings suggest that this inhibitory deficit can be considered characteristic of the illness and that the intensity of the gating abnormality varies according to the severity of BD. |
### Instruction:
Does [ Mid-long term follow-up result in correction of extreme myopia by posterior chamber phakic intraocular lens ]?
### Response:
| Correction of high myopia by ICL implantation is a safe procedure and the results are stable. |
### Instruction:
Do amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy?
### Response:
| Soluble Aβ(1-42) oligomers have long-lasting effects on tau phosphorylation in the rTg4510 model, possibly due to elevations in GSK3. These data suggest that even brief elevations in Aβ production, may have enduring impact on the risk for tauopathy. |
### Instruction:
Is gain of human telomerase RNA gene associated with progression of cervical intraepithelial neoplasia grade I or II?
### Response:
| In conclusion, measurement of hTERC gene gain in CIN-I or CIN-II patients using liquid-based cytological samples could be a useful biomarker to predict the progression of such cervical lesions. In addition, a 4:4 or N:≥5 signal ratio pattern may indicate the unlikeness of spontaneous regression of CIN-I or CIN-II lesions. |
### Instruction:
Is overexpression of interleukin-l7 in tumor-associated macrophages correlated with the differentiation and angiogenesis of laryngeal squamous cell carcinoma?
### Response:
| IL-17 was expressed by TAMs, and IL-17 may significantly correlate to the differentiation and angiogenesis in the development of LSCC. |
### Instruction:
Do influence of post-warm-up recovery time on swim performance in international swimmers?
### Response:
| 200m freestyle performance is faster 20min post-warm-up when compared to 45min probably due to better T(core) maintenance. This has implications for swim race preparation as warm-up procedures should be completed close to entering the pre-race call room, in order to maintain elevated core temperature. |
### Instruction:
Does the vitamin D receptor activator paricalcitol prevent fibrosis and diastolic dysfunction in a murine model of pressure overload?
### Response:
| Treatment with the selective VDR activator paricalcitol reduces myocardial fibrosis and preserves diastolic LV function due to pressure overload in a mouse model. This is associated with a reduced percentage of fibrosis and a decreased expression of ANP and several other tissue markers. |
### Instruction:
Do transforming growth factor-β neutralizing antibodies inhibit subretinal fibrosis in a mouse model?
### Response:
| Our results indicate that TGF-β signaling may contribute to the pathogenesis of subretinal fibrogenesis and TGF-β inhibition may provide an effective, novel treatment of advanced and late-stage neovascular age-related macular degeneration. |
### Instruction:
Does lobe-specific calcium binding in calmodulin regulate endothelial nitric oxide synthase activation?
### Response:
| Our results clearly demonstrate that CaM controls eNOS electron transfer primarily through its lobe-specific calcium binding. |
### Instruction:
Is sonographic gallbladder abnormality associated with intravenous immunoglobulin resistance in Kawasaki disease?
### Response:
| Sonographic gallbladder abnormalities are associated with higher CRP, GPT, neutrophil and IVIG resistance in KD. It can be used as a predictor of IVIG resistance in patients with KD. |
### Instruction:
Does ligand-free estrogen receptor activity complement IGF1R to induce the proliferation of the MCF-7 breast cancer cells?
### Response:
| The basal ER activity in the absence of ligand is sufficient to allow efficient mitogenic action of IGF1R agonists and needs to be blocked to prevent the cell cycle progression. |
### Instruction:
Is haptoglobin present in albumin used as a replacement solution for plasma exchange?
### Response:
| Albumin solution used for PE contained haptoglobin and it explained in part the kinetics removal of plasma haptoglobin observed in the patients. |
### Instruction:
Are iL-1β induction and IL-6 suppression associated with aggravated neuronal damage in a lipopolysaccharide-pretreated kainic acid-induced rat pup seizure model?
### Response:
| Our results showed an increase in the proconvulsant cytokine IL-1β and a decrease in a potentially neuroprotective cytokine, IL-6, in rat pups treated with LPS + KA. These results warrant further investigation into the possible role of IL-1β induction and IL-6 suppression in LPS-promoted neuronal damage. |
### Instruction:
Does eldecalcitol normalize bone turnover markers regardless of their pre-treatment levels?
### Response:
| Eldecalcitol normalizes, but does not overly suppress, bone turnover regardless of baseline levels of bone turnover markers. Thus, it is unlikely that eldecalcitol treatment will increase the risk of severely suppressed bone turnover and therefore deterioration of bone quality, at least for a treatment duration of 3 years. |
### Instruction:
Does phosphatidylinositol-3-phosphate clearance play a key role in autophagosome completion?
### Response:
| Our data thus reveal a key role for PtdIns3P turnover in the regulation of the late steps of autophagosome biogenesis and indicate that the disassembly of the Atg machinery from the surface of autophagosomes is a requisite for their fusion with the vacuole. |
### Instruction:
Is sUMOylation of the α-kleisin subunit of cohesin required for DNA damage-induced cohesion?
### Response:
| These findings demonstrate that SUMOylation of Mcd1 is a novel prerequisite for the establishment of DNA damage-induced cohesion at DSB-proximal regions and cohesion-associating regions (CARs) genome-wide. |
### Instruction:
Does intrathecal injection of spironolactone attenuate radicular pain by inhibition of spinal microglia activation in a rat model?
### Response:
| These results suggest that intrathecal delivery spironolactone has therapeutic effects on radicular pain in rats. Decreasing the activation of glial cells, the production of proinflammatory cytokines and down-regulating the expression and phosphorylation of NMDA receptors in the spinal dorsal horn and dorsal root ganglia are the main mechanisms contributing to its beneficial effects. |
### Instruction:
Is resistance to first-line anti-TB drugs associated with reduced nitric oxide susceptibility in Mycobacterium tuberculosis?
### Response:
| There is a correlation between resistance to first-line anti-TB drugs and reduced NO susceptibility in clinical strains of M. tuberculosis. Further studies including the mechanisms of reduced NO susceptibility are warranted and could identify targets for new therapeutic interventions. |
### Instruction:
Does intracultural variation of knowledge about wild plant used in the Biosphere Reserve Grosses Walsertal ( Austria )?
### Response:
| A majority of respondents is familiar with wild plant uses, however to varying degrees. Knowledge variations depend on the socio-demographic and geographic background of the informants as well as on the domains of knowledge under investigation: women, older informants and homegardeners report more human medicinal applications and applications in drinks than men, younger informants and non-homegardeners; farmers know a greater variety of veterinary medicinal applications than non-farmers; the place of residence relates significantly to food and veterinary uses. Customs are difficult to investigate in standardized matrices. The household-related distribution of work and the general socio-cultural context are especially helpful in order to explain intracultural variation of knowledge in the Grosses Walsertal. |
### Instruction:
Does travel-related change of residence lead to a transitory stress reaction in humans?
### Response:
| The results indicate that not only the change of residence but also its anticipation affects individuals in a transient way. The findings are relevant not only for the basic understanding of the reaction to novel environments but also to travel, tourism as well as rehabilitation, and spa-research. |
### Instruction:
Does slug regulate Cyclin D1 expression by ubiquitin-proteasome pathway in prostate cancer cells?
### Response:
| We found that forced expression of Slug inhibited proliferation of prostate cancer cells through downregulation of cyclin D1 expression. And Slug regulates cyclin D1 expression by ubiquitin-proteasome pathway in PCa cells. |
### Instruction:
Does antenatal diagnosis of fetal genotype determine if maternal hyperglycemia due to a glucokinase mutation requires treatment?
### Response:
| In pregnancies where the mother has hyperglycemia due to a GCK mutation, knowing the fetal GCK genotype guides the management of maternal hyperglycemia. Fetal genotyping should be performed when fetal DNA is available from invasive prenatal diagnostic testing. |
### Instruction:
Is hyperinsulinemia and insulin resistance associated with low T₃/T₄ ratio in pre diabetic euthyroid Pakistani subjects?
### Response:
| Hyperinsulinemia and insulin resistance are associated with low T₃/T₄ ratio in pre-diabetic euthyroid Pakistani subjects. |
### Instruction:
Is preoperative plasma fibrinogen level a useful predictor of adjacent organ involvement in patients with advanced gastric cancer?
### Response:
| Plasma fibrinogen was found to be a clinically useful marker of adjacent organ involvement and overall survival. When a high fibrinogen level is encountered, preoperatively, adjacent organ involvement should be suspected in clinically advanced gastric cancer. |
### Instruction:
Is participation in the child and adult care food program associated with more nutritious foods and beverages in child care?
### Response:
| CACFP participation may be one means by which reimbursement for food can be increased and food offerings improved. Further research should investigate whether promoting CACFP participation can be used to provide healthier nutrition environments in child care and prevent obesity in young children. |
### Instruction:
Is dying a transition?
### Response:
| Understanding dying as transition may induce a radical reinterpretation of what patients need. |
### Instruction:
Are regulatory T cells the most important determinant factor of hepatitis B infection prognosis : a systematic review and meta-analysis?
### Response:
| Tregs influence HBV infected patients in various states. Tregs determine the disease prognosis by leading to infection progression and impairing immune response. So, Tregs are therapeutic target for immunotherapy of HBV infection. |
### Instruction:
Do vascular endothelial growth factor polymorphisms increase the risk of developing Graves ' disease?
### Response:
| VEGF +405 polymorphism may be a risk factor for GD, while the -2578 SNP is related with increased autoantibody production. |
### Instruction:
Is plasmacytoid dendritic cell interferon-α production to R-848 stimulation decreased in male infants?
### Response:
| Androgen-mediated regulation of pDC TLR7-driven innate immune responses may contribute to the observed sex differences in response to infections during early infancy. |
### Instruction:
Do pancreatic cancer cells enhance the ability of collagen internalization during epithelial-mesenchymal transition?
### Response:
| Pancreatic cancer cells are capable of collagen internalization, which is enhanced by EMT. This ECM clearance system may be a novel mechanism for cellular invasion and a potential therapeutic target in pancreatic cancer. |
### Instruction:
Does rab11 regulate planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis?
### Response:
| These results establish a requirement for Rab11 in MCC development and support a two-step model, in which the initial polarization of MCC precursors is critical for their integration into the superficial cell layer. |
### Instruction:
Does selenite enhance and prolongs the efficacy of cisplatin treatment of human ovarian tumor xenografts?
### Response:
| The ability of selenite to prolong the effectiveness of repetitive cisplatin treatment, most likely by preventing the development of resistance, makes it a strong candidate for inclusion in clinical trials. |
### Instruction:
Do expanded effector memory T-lymphocytes in DBA/2 mice inhibit the growth of SL2 tumours?
### Response:
| SL2 tumours induce expansion of effector memory lymphocytes in DBA/2 mice. However, expanded effector memory lymphocytes do not inhibit the growth of tumours. |
### Instruction:
Is rET/PTC rearrangement prevalent in follicular Hürthle cell carcinomas?
### Response:
| Our study has shown a significant association between RET/PTC rearrangements and FHCCs with a solid growth pattern, thus raising the possibility of using tyrosine kinase inhibitors for the treatment of patients with FHCCs, which are often refractory to radioiodine treatment. |
### Instruction:
Do fermentable fibers affect satiety or food intake by women who do not practice restrained eating?
### Response:
| Functional fibers incorporated into chocolate bars at high fiber doses produce greater gastrointestinal symptoms than control, but do not alter satiety, hunger, or food intake compared with control in the short term. |
### Instruction:
Does mometasone furoate nasal spray relieve the ocular symptoms of seasonal allergic rhinoconjunctivitis?
### Response:
| In patients with SAR, INSs tend to decrease the substance P concentration in tears, which is correlated with the severity of ocular and nasal symptoms. |
### Instruction:
Does angiopoietin-2 inhibition using siRNA or the peptide antagonist L1-10 result in antitumor activity in human neuroblastoma?
### Response:
| This first demonstration of beneficial angiopoietin-2 inhibition in neuroblastoma offers an additional approach for future therapy strategies, especially by using L1-10 in the setting of minimal residual disease. |
### Instruction:
Do tertiary centres have improved survival compared to other hospitals in the Copenhagen area after out-of-hospital cardiac arrest?
### Response:
| Admission to tertiary centres is associated with lower mortality rates after OHCA compared with non-tertiary hospitals. |
### Instruction:
Is the Modification of Diet in Renal Disease 4-calculated glomerular filtration rate a better prognostic factor of cardiovascular events than classical cardiovascular risk factors in patients with peripheral arterial disease?
### Response:
| The MDRD-4 GFR was a better predictor of risk of death or infarction than classical cardiovascular risk factors in patients with PAD. This suggests that its routine use in the initial evaluation in patients with PAD is beneficial. |
### Instruction:
Is tracheostomy tube change before day 7 associated with earlier use of speaking valve and earlier oral intake?
### Response:
| Tracheostomy tube change before day 7 is associated with earlier ability to tolerate speaking valve and oral intake. In this series, early tracheostomy tube change was not associated with an increased rate of complications. |
### Instruction:
Does modulation of Lactobacillus plantarum gastrointestinal robustness by fermentation conditions enable identification of bacterial robustness markers?
### Response:
| Transcriptome trait matching enabled the identification of biomarkers for bacterial (gut-)robustness, which is important for our molecular understanding of GI-tract survival and could facilitate the design of culture conditions aimed to enhance probiotic culture robustness. |
### Instruction:
Does anti-obesity sodium tungstate treatment trigger axonal and glial plasticity in hypothalamic feeding centers?
### Response:
| Altogether, these results suggest that sodium tungstate regulates proteins involved in axonal and glial plasticity. The fact that sodium tungstate could modulate hypothalamic plasticity and networks in adulthood makes it a possible and interesting therapeutic strategy not only for obesity management, but also for other neurodegenerative illnesses like Alzheimer's disease. |
### Instruction:
Does magnetic bionanoparticle enhance homing of endothelial progenitor cells in mouse hindlimb ischemia?
### Response:
| MP transfer with magnet application can be a promising novel strategy to enhance homing efficacy and outcomes of current stem cell therapy. |
### Instruction:
Is youth screen-time behaviour associated with cardiovascular risk in young adulthood : the European Youth Heart Study?
### Response:
| Prolonged TV viewing and total screen time during leisure time in adolescence, and increases in these behaviours, are associated with unfavourable levels of several cardiovascular risk factors in young adulthood. |
### Instruction:
Does [ Radioiodine-131 therapy improve sex hormones and sexual function in male patients with Graves ' disease ]?
### Response:
| The E2, T and LH levels are increased while the IIEF-5 score decreased markedly in male GD patients. Six-month treatment with I-131 can not only restore the E2, T and LH levels to normal but also significantly improve the patient's sexual function. |
### Instruction:
Does smad4 expression in hepatocellular carcinoma differ by hepatitis status?
### Response:
| Patients with hepatitis viral infection, at higher risk for HCC, exhibited increased Smad4 protein expression suggesting hepatitis virus may modulate Smad4 expression, which is functionally distinct from its putative role as a TSG. Smad4 expression may thus be an applicable marker for diagnosis and/or a target to develop therapeutic agents for HCC. |
### Instruction:
Do a clinical `` near miss '' highlights risk management issues surrounding ultrasound-guided and wire-localised breast resections?
### Response:
| It is evident that breast cancer patients undergoing image-guided resection are exposed to an additional layer of clinical risks. These risks are not offset by the World Health Organisation surgical safety checklist in its present guise. Here, we review a number of simple and inexpensive changes to the system that may improve the safety of the breast cancer patient undergoing surgery. |
### Instruction:
Is sentinel node biopsy indicated for thin melanomas ≥0.76 mm?
### Response:
| SLN metastases were seen in 8.4% of thin melanomas ≥0.76 mm, including 5% of T1a melanomas ≥0.76 mm. We believe these rates are sufficient to justify consideration of SLNB in these patients, while the indications for SLNB in melanomas <0.76 mm remain to be defined. |
### Instruction:
Does serum sclerostin increase in healthy adult men during bed rest?
### Response:
| In healthy men subjected to controlled bed rest for 90 d, serum sclerostin increased, with a peak at 60, whereas serum PTH declined, and urinary calcium and bone resorption markers increased. |
### Instruction:
Does topical application of Sadat-Habdan mesenchymal stimulating peptide ( SHMSP ) accelerate wound healing in diabetic rabbits?
### Response:
| Topical application of SHMSP improves wound healing in diabetic rabbits. |
### Instruction:
Do [ Analysis of resistance phenotype and homology of Klebsiella pneumoniae in burn patients ]?
### Response:
| KPN in burn patients with infection in our institute are highly resistant to commonly used antibiotics in clinic, but carbapenems antibiotics can be used for the treatment. Most of the ESBL-producing KPN strains carry two or three drug-resistant genes, and the main gene type of them is type A. |
### Instruction:
Do deficits in visuospatial processing contribute to quantitative measures of freezing of gait in Parkinson 's disease?
### Response:
| Deficits in visuospatial perception and reasoning not in executive function differentiated freezers from non-freezers. Deficits in visuospatial processing negatively correlated with all SIP freeze metrics, whereas deficits in executive function were only correlated with SIP arrhythmicity, the FOGq total and the duration of freezing episodes. These results suggest that deficits in visuospatial processing to perform a motor task contribute to FOG and that different cognitive deficits may contribute to different aspects of freezing in PD. This is the first study to our knowledge that has compared metrics of freezing to cognitive tasks in the visuospatial and visual reasoning domains. |
### Instruction:
Do tumor necrosis factor-α and Porphyromonas gingivalis lipopolysaccharides decrease periostin in human periodontal ligament fibroblasts?
### Response:
| Inflammatory mediators (TNF-α) and bacterial virulence factors (P. gingivalis LPS) decrease periostin expression in human PDL fibroblasts. These results support a potential mechanism by which periostin alterations could act as a contributing factor during periodontal disease progression. |
### Instruction:
Does orexin-A facilitate emergence from propofol anesthesia in the rat?
### Response:
| Our findings indicate that activity of orexinergic neurons is inhibited by propofol anesthesia, and the orexin signals in basal forebrain are involved in anesthesia-arousal regulation from propofol anesthesia. |
### Instruction:
Does novel Markov model of induced pluripotency predict gene expression changes in reprogramming?
### Response:
| This lands further support on our general rules of gene regulation network in iPSC reprogramming. This model may help uncover the basic mechanism of reprogramming and improve the efficiency of converting somatic cells to iPSCs. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.