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### Instruction:
Is 3q26 amplification an effective negative triage test for LSIL : a historical prospective study?
### Response:
| 3q26 gain demonstrates high sensitivity and NPV as a negative triage test for women with LSIL, allowing possible guideline changes to routine surveillance instead of immediate colposcopy. Prospective studies are ongoing to establish the sensitivity, specificity, PPV and NPV of 3q26 gain for LSIL over time. |
### Instruction:
Does [ Wnt3a induce epithelial-mesenchymal transition of lens epithelial cells ]?
### Response:
| Wnt3a activates Wnt/β-catenin signaling pathway, induces EMT in lens epithelial cells and then increases mobility and migration of lens epithelial cells. |
### Instruction:
Does aerosolized perfluorocarbon improve gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome?
### Response:
| Aerosolized PFD improves pulmonary function in preterm lambs and should be further investigated as an alternative mode of PFC administration. |
### Instruction:
Does electroacupuncture improve orthostatic tolerance in healthy individuals via improving cardiac function and activating the sympathetic system?
### Response:
| Electroacupuncture at PC-6 is effective in improving orthostatic tolerance. Cardiac function improvement and sympathetic activation are responsible for the improved orthostatic tolerance after EA. EA represents a novel intervention against OI. |
### Instruction:
Is lipid accumulation product a powerful index for recognizing insulin resistance in non-diabetic individuals?
### Response:
| LAP is closely associated with HOMA-IR and is a powerful index that outperforms BMI and WC in identifying IR in non-diabetic individuals. |
### Instruction:
Do extracellular IgC2 constant domains of CEACAMs mediate PI3K sensitivity during uptake of pathogens?
### Response:
| Our results provide novel mechanistic insight into CEACAM1-mediated endocytosis and suggest that epithelial CEACAMs associate in cis with other membrane receptor(s) via their extracellular domains to trigger bacterial uptake in a PI3K-dependent manner. |
### Instruction:
Does the HyVac4 subunit vaccine efficiently boost BCG-primed anti-mycobacterial protective immunity?
### Response:
| H4-IC31® can efficiently boost BCG-primed immunity leading to an increased protective anti-M.tb immune response dominated by IFNγ/TNFα/IL-2 or TNFα/IL2 producing CD4 T cells. H4 in the CD4 T cell inducing adjuvant IC31® is presently in clinical trials. |
### Instruction:
Is a retinoblastoma orthologue a major regulator of S-phase , mitotic , and developmental gene expression in Dictyostelium?
### Response:
| Like its mammalian counterpart Dictyostelium, RblA plays a dual role, regulating cell-cycle progression and transcriptional events leading to terminal differentiation. In the absence of a G1 phase, however, RblA functions in late G2 controlling the expression of both S-phase and mitotic genes. |
### Instruction:
Does the transcription factor c-Jun protect against liver damage following activated β-Catenin signaling?
### Response:
| These data indicate that c-Jun is not a primary target of β-Catenin signaling in the liver, but rather protects against liver damage, which in turn may promote liver tumorigenesis. |
### Instruction:
Are the plastid-localized pfkB-type carbohydrate kinases FRUCTOKINASE-LIKE 1 and 2 essential for growth and development of Arabidopsis thaliana?
### Response:
| Our results demonstrate that each FLN protein contributes to wild type growth, and acting additively are absolutely essential for plant growth and development. |
### Instruction:
Does red blood cell transfusion affect microdialysis-assessed interstitial lactate/pyruvate ratio in critically ill patients with late sepsis?
### Response:
| Tissue oxygenation is affected by RBC transfusion in critically ill septic patients. Monitoring of tissue LP ratio by microdialysis may represent a useful method for individual clinical management. |
### Instruction:
Does [ PreC/C gene-targeting RNA interference suppress hepatitis B virus replication and expression in human hepatoma cells ]?
### Response:
| For the first time it has been found that RNAi induced by siRNA/shRNA targeting HBV preC/C gene is effective and specific in inhibiting HBV replication and expression in human hepatoma cells Huh-7 and HepG2.2.15 cells. Our data suggest that RNAi may provide an effective, viable approach in gene therapy to treating major infectious diseases such as HBV/HCV/HIV infection. |
### Instruction:
Is the hyperdense posterior cerebral artery sign in CT related to larger ischemic lesion volume?
### Response:
| The HPCA may be considered as an additional marker of early brain infarct, especially with large lesion volume. |
### Instruction:
Is expression of PaNAC01 , a Picea abies CUP-SHAPED COTYLEDON orthologue , regulated by polar auxin transport and associated with differentiation of the shoot apical meristem and formation of separated cotyledons?
### Response:
| The results show that CUC-like genes with distinct signature motifs existed before the separation of angiosperms and gymnosperms approx. 300 million years ago, and suggest a conserved function between PaNAC01 and CUC1/CUC2. |
### Instruction:
Does pranic meditation affect phagocyte functions and hormonal levels of recent practitioners?
### Response:
| This is the first study to show that a short program of pranic meditation practice was able to upregulate the function and metabolism of phagocytes, in parallel with the reduction of the plasma levels of corticotrophin. The results of this study point to a possible causal effect between these events, and indicate that pranic meditation could be useful for stimulating the function and metabolism of phagocytes. |
### Instruction:
Does complement receptor-3 negatively regulate the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin?
### Response:
| CR3 both activates and downregulates myelin phagocytosis at the same time. Activation was previously documented. We presently demonstrate that downregulation is mediated through Syk, which advances the inactive phosphorylated state of cofilin. Self-negative control of phagocytosis by the phagocytic receptor can be useful in protecting phagocytes from excessive phagocytosis (i.e., "overeating") during extended exposure to particles that are destined for ingestion. |
### Instruction:
Is red blood cell transfusion associated with troponin release after elective off-pump coronary artery bypass surgery?
### Response:
| Red blood cell transfusion is associated with increased troponin I release after elective off-pump coronary artery bypass graft surgery independently of hemoglobin and hematocrit nadirs. These findings suggest that prevention of major bleeding requiring blood transfusion may be cardioprotective during coronary surgery. Further studies are needed to verify whether troponin release is affected simply by RBC transfusion or by unstable hemodynamic conditions in presence of mild and severe anemia. |
### Instruction:
Does systematic exposure to recreation centers increase use by Latino families with young children?
### Response:
| CRCs that develop culturally tailored programs that invite Latino families inside can increase sustained CRC use for physical activity in this population at heightened risk for childhood obesity. |
### Instruction:
Does caveolin-1 play a critical role in the differentiation of monocytes into macrophages?
### Response:
| Caveolin-1 promotes monocyte to macrophage differentiation through the regulation of EGR-1 transcriptional activity, suggesting that phagocytic caveolin-1 may be critical for atherogenesis. |
### Instruction:
Is vascular smooth muscle cell Smad4 gene important for mouse vascular development?
### Response:
| SMC-specific deletion of Smad4 results in vascular defects that lead to embryonic lethality in mice, which may be attributed to decreased VSMC differentiation, proliferation, migration, as well as cell attachment and spreading. The transforming growth factor-β signaling pathway contributes to VSMC differentiation and function, whereas the bone morphogenetic protein signaling pathway regulates VSMC migration. These studies provide important insight into the role of Smad4 and its upstream Smads in regulating SMC function and vascular development of mice. |
### Instruction:
Is emergency medical service hospital prenotification associated with improved evaluation and treatment of acute ischemic stroke?
### Response:
| EMS hospital prenotification is associated with improved evaluation, timelier stroke treatment, and more eligible patients treated with tPA. These results support the need for initiatives targeted at increasing EMS prenotification rates as a mechanism from improving quality of care and outcomes in stroke. |
### Instruction:
Does the development of an assessment and intervention fall guide for older hospitalized adults with cardiac conditions?
### Response:
| The project demonstrated an evidence-informed process that was used to design and implement this assessment tool and a change in nursing practice. It also provided information about the prevalence of cardiac-related risk fall factors that were utilized in the development of this Assessment and Intervention Falls Guide for elderly people. |
### Instruction:
Is tea consumption inversely associated with weight status and other markers for metabolic syndrome in US adults?
### Response:
| These cross-sectional results support growing laboratory data, which demonstrate the negative association of hot tea intake with markers of MetS. |
### Instruction:
Do [ NF-κB subunits regulate maspin expression in prostate cancer cells in vitro ]?
### Response:
| The classical and alternative NF-κB activitions are sustained in androgen-independent prostate cancer cell lines. The expressions of RelB and maspin are inversely correlated in these cancer cells. The expression of RelB negatively regulates the endogenous expression of maspin, then interferes the cell survival. RelA is not involved in the regulation of maspin expression. |
### Instruction:
Are levels of circulating endothelial cells and colony-forming units influenced by age and dyslipidemia?
### Response:
| Levels of CECs increase and CFUs decrease with age. In childhood, before the onset of clinically detectable cardiovascular dysfunction, children with a major risk factor for atherosclerotic disease have levels of these indexes of vascular injury and repair approaching those seen in adults. |
### Instruction:
Are respiratory therapy organizational changes associated with increased respiratory care utilization?
### Response:
| A multi-component intervention, including an increase in RT/patient ratio, improved RT orientation, and establishment of a core staffing model, was associated with increased respiratory resource utilization and evidence-based practice, specifically BALs and SBTs. |
### Instruction:
Do gold nanoparticles induce apoptosis in MCF-7 human breast cancer cells?
### Response:
| To the best of our knowledge this is the first report showing that gold nanoparticles induce apoptosis in MCF-7 cells via p53, bax/bcl-2 and caspase pathways. |
### Instruction:
Does eye feature in three Danish patients with multisystemic smooth muscle dysfunction syndrome?
### Response:
| Congenital mydriasis is an extremely rare pupil anomaly and is the feature for the early diagnosis of this new syndrome. The ophthalmologist should act in close collaboration with other specialists owing to the risk of aortic and cerebrovascular diseases and other complications associated with this disorder. |
### Instruction:
Is the correlation between the hyperacusis questionnaire and uncomfortable loudness levels dependent on emotional exhaustion?
### Response:
| The results emphasize the need to take other factors, such as emotional exhaustion (long-term stress), into consideration when assessing hyperacusis with a questionnaire. |
### Instruction:
Does cardiotrophin-1 induce sarcoplasmic reticulum Ca ( 2+ ) leak and arrhythmogenesis in adult rat ventricular myocytes?
### Response:
| Our findings provide evidence that cardiomyocytes treated with CT-1 present high spontaneous Ca(2+) release during diastole, a mechanism linked to arrhythmogenicity in the pathologic heart. |
### Instruction:
Do cisplatin and ultra-violet-C synergistically down-regulate receptor tyrosine kinases in human colorectal cancer cells?
### Response:
| The combination of low dose cisplatin and low dose UV-C synergistically exerted anti-cancer effect by down-regulating RTK, such as EGFR and HER2. These findings may provide a novel strategy for the treatment of patients with colorectal cancer. |
### Instruction:
Is carbohydrate antigen 19-9 a prognostic and predictive biomarker in patients with advanced pancreatic cancer who receive gemcitabine-containing chemotherapy : a pooled analysis of 6 prospective trials?
### Response:
| In patients who have advanced pancreatic cancer treated with gemcitabine-containing regimens baseline CA19-9 is prognostic for outcome. A decline in CA19-9 after the second cycle of chemotherapy is not predictive of improved mOS or mTTP; thus, CA19-9 decline is not a useful surrogate endpoint in clinical trials. Clinically, a ≥ 5% rise in CA19-9 after 2 cycles of chemotherapy serves as a negative predictive marker. |
### Instruction:
Does a dietary supplement containing chlorophytum borivilianum and velvet bean improve sleep quality in men and women?
### Response:
| An investigational dietary supplement containing the active ingredients Chlorophytum borivilianum and Velvet bean improves sleep quality in men and women. Additional placebo controlled trials are needed to corroborate these findings in individuals with self-reported sleeping difficulty. |
### Instruction:
Are stallion spermatozoa selected by single layer centrifugation capable of fertilization after storage for up to 96 h at 6°C prior to artificial insemination?
### Response:
| SLC-selected stallion spermatozoa stored for up to 96 h are capable of fertilization. |
### Instruction:
Is the prostaglandin E2 receptor , EP2 , upregulated in the dorsal root ganglion after painful cervical facet joint injury in the rat?
### Response:
| Painful cervical facet joint distraction induces an immediate and sustained increase of EP2 expression in the DRG, implicating peripheral inflammation in the initiation and maintenance of facet joint pain. The transient increase in neuronal EP2 suggests, as in other painful joint conditions, that after joint injury nonneuronal cells may migrate to the DRG, some of which likely express EP2. |
### Instruction:
Is histone H3K79 methyltransferase Dot1L directly activated by thyroid hormone receptor during Xenopus metamorphosis?
### Response:
| Our findings suggest that TR activates Dot1L, which in turn participates in metamorphosis through a positive feedback to enhance H3K79 methylation and gene activation by liganded TR. |
### Instruction:
Does planning estimate for the provision of core mental health services in Queensland 2007 to 2017?
### Response:
| The recommended targets pointed to specific areas for priority in Queensland, notably the need for additional acute inpatient services for older persons and expansion of clinical ambulatory care, residential rehabilitation and supported accommodation services. The development of nationally agreed planning targets for public mental health services and the mental health community support sector were identified as priorities. |
### Instruction:
Is long duration of radiofrequency energy delivery an independent predictor of clinical recurrence after catheter ablation of atrial fibrillation : over 500 cases experience?
### Response:
| In this single center consistent study of over 500 cases of AF ablation, patients with AF recurrence had a larger atrium, longer ablation time, and a higher chance of early recurrence than those remained in sinus rhythm. Inadvertent, long duration of ablation was an independent predictor of worse clinical outcomes after catheter ablation of AF. |
### Instruction:
Does [ research on relationship between genetic differentiation and chemical variation of Cinnamomum migao ]?
### Response:
| The genetic diversity of C. migao was relatively high at the population levels, while it is low within the population levels, the relationship between chemical variation and genetic diversity was not obvious, that may indicate that other factors causes the chemical variation of C. migao. |
### Instruction:
Does sca-1 knockout impair myocardial and cardiac progenitor cell function?
### Response:
| Genetic deletion of Sca-1 causes primary cardiac defects in myocardial contractility and repair consistent with impairment of resident cardiac progenitor cell proliferative capacity associated with altered canonical Wnt signaling. |
### Instruction:
Do institutional peer support mediates the impact of physical declines on depressive symptoms of nursing home residents?
### Response:
| Findings of this study reveal that institutional peer support positively contributes to the psychological well-being of nursing home residents. |
### Instruction:
Does inhibition of p38 MAPK reduce loss of primary sensory neurons after nerve transection?
### Response:
| These data suggest the role of p38 in sensory neuronal loss after nerve transection. Future studies should be done to confirm the apoptotic role of p38 in this condition. |
### Instruction:
Is loss of succinate dehydrogenase subunit B ( SDHB ) expression limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours : a comprehensive genotype-phenotype correlation study?
### Response:
| SDHB-deficient GISTs are wild-type gastric tumours with distinctive histology. Immunohistochemistry for SDHB can be used to confirm the diagnosis of this tumour class. SDHB expression is retained in all GISTs with KIT and PDGFRA mutations. |
### Instruction:
Are important technical parameters presented in reports of intraoral digital radiography in endodontic treatment : recommendations for future studies?
### Response:
| The methodologic quality of future publications must be improved to permit replication of studies and comparison of results between studies in dental digital radiography. Our recommendations can improve the quality of studies on diagnostic accuracy. |
### Instruction:
Is poor health , but not fracture and fall risk , associated with nonattendance at bone mineral density screening?
### Response:
| Failure to attend osteoporosis screening is associated with significant health problems and poor self-rated health. Improving point of care access may increase the amount of osteoporosis screening among women with multiple comorbidities. |
### Instruction:
Is serum uric acid level an indicator of total cholesterol and low density lipoprotein cholesterol in men below 45 years in age but not older males?
### Response:
| Thus, serum uric acid levels in the normal range might be a good indicator of the level of triglycerides and very low density lipoprotein cholesterol in men encompassing a wide age range but of total cholesterol and low density lipoprotein cholesterol only in men less than 45 years in age. |
### Instruction:
Are elevated serum chemerin levels associated with the presence of coronary artery disease in patients with type 2 diabetes?
### Response:
| There is an independent association between serum levels of chemerin and the presence of CAD in patients with T2DM. |
### Instruction:
Is the inhibition of the pemetrexed-activated MAPK pathway via sorafenib involved in the synergistic mechanism of sorafenib subsequent potentiation of pemetrexed cytotoxicity in EGFR TKI-resistant cell lines?
### Response:
| The sequence of pemetrexed followed by sorafenib had a synergistic effect and an advantage over other sequences in EGFR TKI-resistant NSCLC cell lines. The synergistic mechanism was due to sorafenib subsequently inhibiting the pemetrexed-activated MAPK signaling pathway. The results may provide molecular evidence to support clinical treatment strategies for patients with EGFR TKI-resistant lung cancer. |
### Instruction:
Is voriconazole delivered from antifungal-loaded bone cement?
### Response:
| Voriconazole release from ALBC increases with dose and is bioactive. Loss in compressive strength is greater after elution and with higher dose. |
### Instruction:
Is efficacy of ezetimibe associated with gender and baseline lipid levels in patients with type 2 diabetes?
### Response:
| Addition of ezetimibe to ongoing statin therapy was effective in patients with type 2 diabetes. Male sex and baseline LDL-C levels are independent predictors of marked TC reduction by ezetimibe treatment. |
### Instruction:
Does shilajit attenuate behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats?
### Response:
| The results indicate that shilajit mitigates the effects of CFS in this model possibly through the modulation of HPA axis and preservation of mitochondrial function and integrity. The reversal of CFS-induced behavioral symptoms and mitochondrial bioenergetics by shilajit indicates mitochondria as a potential target for treatment of CFS. |
### Instruction:
Does trypsin inhibit lipopolysaccharide signaling in macrophages via toll-like receptor 4 accessory molecules?
### Response:
| Trypsin inhibited LPS signaling PAR-independently via degradation of TLR4 accessory molecules. This observation provides a better understanding of the complicated immune response in acute pancreatitis. |
### Instruction:
Is fibulin-5 protein reduced in the lung of patients with spontaneous pneumothorax who are under 25 years old?
### Response:
| We showed that fibulin-5 is reduced in patients with PSP who are younger than 25 years. |
### Instruction:
Do increased ferritin concentrations correlate with insulin resistance in female type 2 diabetic patients?
### Response:
| Iron overload, which produces elevated levels of ferritin, may augment insulin resistance in female but not in male type 2 diabetes. Longitudinal studies are warranted to establish relationships between iron stores and diabetes development in men and women of different ethnicities. |
### Instruction:
Is routine drainage necessary after laparoscopic gastric bypass?
### Response:
| Routine abdominal drainage is not necessary after a successful laparoscopic gastric bypass for morbidly obese patients. Drainage omission may contribute to a quicker recovery without additional surgical complications. |
### Instruction:
Is residual viability a predictor of the perfusion enhancement obtained with the cell therapy of chronic myocardial infarction : a pilot multimodal imaging study?
### Response:
| Perfusion enhancement, obtained with BMNCs in areas of chronic MI, might require an intermediate level of viability documented with FDG-PET and MRI and that totally necrotic MI seems refractory to this cell therapy technique. |
### Instruction:
Are th1 and Th17 cell subpopulations enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis?
### Response:
| This study is the first to describe significantly higher proportions of Th1 and Th17 T helper cell subsets in the peripheral blood of sJIA patients. These proinflammatory cells may play a pathogenic role in sJIA. Our data also emphasize the importance of using paediatric age-matched control subjects when evaluating the T-cell cytokine profile in JIA. |
### Instruction:
Does nOTCH1 signaling promote human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches?
### Response:
| These results reveal a functional hierarchy within the LIC population based on NOTCH1 activation, which renders LIC susceptible to targeted NOTCH1 inhibition and highlights the utility of NOTCH1 antibody targeting as a key component of malignant stem cell eradication strategies. |
### Instruction:
Is vessel-associated transforming growth factor-beta1 ( TGF-β1 ) increased in the bronchial reticular basement membrane in COPD and normal smokers?
### Response:
| Vessel-associated TGF-β1 activity is increased in the bronchial Rbm in smokers and especially those with COPD. |
### Instruction:
Is broad resistance to ACCase inhibiting herbicides in a ryegrass population due only to a cysteine to arginine mutation in the target enzyme?
### Response:
| This study establishes the clear and unambiguous importance of the C2088R target site mutation in conferring broad resistance to ten commonly used ACCase inhibiting herbicides. It also demonstrates that low levels "creeping", multigenic, non target site resistance, is not always selected before single gene target site resistance appears in grass weed populations subjected to herbicide selection pressure. |
### Instruction:
Are severity of anxiety and depression related to a higher perception of adverse effects of antiepileptic drugs?
### Response:
| Adverse effects to AEDs can be related with the presence of psychiatric disorders such as anxiety and depression in patients with epilepsy. |
### Instruction:
Do clonal chromosome anomalies affecting FLI1 mimic inherited thrombocytopenia of the Paris-Trousseau type?
### Response:
| Although our patient presented with nearly all the characteristics of TCPT, her illness was acquired instead of being inherited and the most appropriate diagnosis is that of the unilineage dysplasia 'refractory THC.' This observation suggests that appropriate cytogenetic investigations should be always considered in patients with acquired THC of unknown origin. |
### Instruction:
Is mitochondrial copy number associated with colorectal cancer risk?
### Response:
| This is the first prospectively designed study to show a U-shaped association between the relative mtDNA copy number and risk of colorectal cancer. |
### Instruction:
Is progesterone-dependent regulation of endometrial cannabinoid receptor type 1 ( CB1-R ) expression disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin ( TCDD )?
### Response:
| Our studies reveal a role for the anti-inflammatory actions of progesterone in regulating endometrial cannabinoid signaling, which is disrupted in women with endometriosis. We demonstrate for the first time that acute TCDD exposure disrupts cannabinoid signaling in the human endometrium. |
### Instruction:
Does lymph node yield at radical cystectomy predict mortality in node-negative and not node-positive patients?
### Response:
| Lymph node count at radical cystectomy is associated with both OS and DSS in patients without nodal metastases. However, in patients with node-positive disease, node count is not an independent predictor of survival suggesting that it is likely a proxy for other patient and provider factors in these individuals. |
### Instruction:
Is the Dyspnoea , Obstruction , Smoking , Exacerbation ( DOSE ) index predictive of mortality in COPD?
### Response:
| The DOSE index is associated with mortality in COPD patients in primary and secondary care and can be used to assess prognosis in addition to other clinically relevant issues. |
### Instruction:
Is suicide preventable , sometimes?
### Response:
| Suicide may not always be avoidable. This does not mean that every effort should not be made to prevent it or vigorously treat illnesses that are often contributory. The assumption, however, may give rise to undue optimism, and unjustified blame when suicides do occur. |
### Instruction:
Do t-cell numbers and antigen-specific T-cell function follow different circadian rhythms?
### Response:
| Taken together, our data reveal a circadian regulation of T-cell immune responses in the peripheral blood of humans under physiological conditions. This knowledge may be of practical consequence for the timing of blood sampling for functional T-cell assays as well as for immunosuppressive drug intake after organ transplantation, where T-cell function may be influenced not only by drug-mediated inhibition but also by circadian fluctuations in T-cell reactivity. |
### Instruction:
Does ankle joint mobilization decrease hypersensitivity by activation of peripheral opioid receptors in a mouse model of postoperative pain?
### Response:
| Our results indicate that joint mobilization reduces postoperative pain by activation of the peripheral opioid pathway. However, antihypersensitivity induced by AJM is apparently not limited by the number of opioid-containing leukocytes but by opioid receptors availability in sensory neurons. A better understanding of the peripheral mechanisms of AJM could stimulate therapists to integrate joint mobilization with strategies also known to influence endogenous pain control, such as exercise, acupuncture, and transcutaneous electrical nerve stimulation to potentiate endogenous analgesia. |
### Instruction:
Is polymorphism of angiotensin I-converting enzyme gene related to oral cancer and lymph node metastasis in male betel quid chewers?
### Response:
| Our data suggest that the ACE gene polymorphisms may be associated with increased susceptibility to OPL and oral cancer and lymph node metastasis from oral cancer. |
### Instruction:
Does baicalin induce apoptosis in leukemia HL-60/ADR cells via possible down-regulation of the PI3K/Akt signaling pathway?
### Response:
| We conclude that baicalin may induce HL-60/ADR cell apoptosis through the PI3K/AKT signaling pathway. |
### Instruction:
Does inhalation exposure to smoke from synthetic `` marijuana '' produce potent cannabimimetic effects in mice?
### Response:
| Inhalation exposure to a product containing JWH-018 penetrates into the brain and other organs and produces CB(1) receptor-mediated behavioral pharmacological effects in mice. The increased potency of JWH-018 compared to THC, the variable amount of drug added to various herbal products, and unknown toxicity, undoubtedly contribute to public health risks of synthetic cannabinoids. |
### Instruction:
Are aGT gene polymorphisms ( M235T , T174M ) associated with coronary heart disease in a Chinese population?
### Response:
| The meta-analyses indicated the significant associations of two AGT polymorphisms (M235T, T174M) with CHD risk in the Chinese population. |
### Instruction:
Does myosin light chain kinase inhibitor inhibit dextran sulfate sodium-induced colitis in mice?
### Response:
| ML-7 has a significant anti-colitis effect in colitis mice. It is mainly associated with the inhibition of the epithelial MLCK protein expression, resulting in ameliorated intestinal mucosal permeability. |
### Instruction:
Is a sutureless aortic stent-graft based on a nitinol scaffold bonded to a compliant nanocomposite polymer durable for 10 years in a simulated in vitro model?
### Response:
| Simulated physiological in vivo hydrodynamic loading has no significant degradative effect on an innovative sutureless stent-graft made from POSS-PCU nanocomposite polymer. Sutureless technology incorporating nitinol stents proved to be robust, with no separation over an accelerated 10-year cycle, which may allow development of durable stent-grafts with better compliance. |
### Instruction:
Does anterior impingement test for labral lesions have high positive predictive value?
### Response:
| Although the sensitivity of the anterior impingement test did not reach a sufficient level for detecting anterosuperior labral lesions, we believe the high positive predictive value makes the test useful. |
### Instruction:
Is fungicidal activity of lysozyme inhibited in vitro by commercial sinus irrigation solutions?
### Response:
| The in vitro FA of lysozyme is dependent on the ionic strength of the solution. The use of sinus irrigation solutions should be further evaluated with regard to maintaining functional activity of cationic antimicrobial peptides involved in sinonasal innate immunity. |
### Instruction:
Are rheumatoid arthritis-associated polymorphisms at 6q23 associated with radiological damage in autoantibody-positive RA?
### Response:
| Established RA risk markers at 6q23 are associated also with radiographic severity in autoantibody-positive RA; as for susceptibility, the association for these markers in combination is stronger than that for markers alone. |
### Instruction:
Does the chemokine decoy receptor D6 prevent excessive inflammation and adverse ventricular remodeling after myocardial infarction?
### Response:
| We show for the first time that the chemokine decoy receptor D6 limits CC-chemokine-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction. |
### Instruction:
Do self-assembling peptide-based nanoparticles enhance anticancer effect of ellipticine in vitro and in vivo?
### Response:
| The anticancer activity observed in this study coupled with minimal side effects encourages further development of peptide-mediated delivery of anticancer drugs, ellipticine in the present case, for clinical application. |
### Instruction:
Does δ-Opioid receptor agonist SNC80 induce central antinociception mediated by Ca2+ -activated Cl- channels?
### Response:
| These data provide evidence for the involvement of CaCCs in δ-opioid receptor-induced central antinociception resulting from receptor activation by the agonist SNC80. CaCC activation does not appear to be involved when µ- and κ-opioid receptors are activated. |
### Instruction:
Does cocultivation of phytopathogenic Fusarium and Alternaria strains affect fungal growth and mycotoxin production?
### Response:
| The interfungal competitive effects aid the understanding of the processes of competition of both fungi in natural environments and the involvement of mycotoxins as antifungal factors. |
### Instruction:
Does pristimerin inhibit breast cancer cell migration by up- regulating regulator of G protein signaling 4 expression?
### Response:
| Pristmerin inhibits proteasomal activity and increases the levels of RGS4, inhibiting the migration and invasion of breast cancer cells. |
### Instruction:
Are multi-stemmed trees of Nothofagus pumilio second-growth forest in Patagonia formed by highly related individuals?
### Response:
| Tree clusters that are merged at the edge of the second-growth forest of N. pumilio are composed of stems of the same genotype and of other genotypes that are highly related (but not always). It is suggested that this peculiar genetic structure results from a combination of several causes, including selection for merging of related individuals. |
### Instruction:
Does iron deficiency anemia in infancy exert long-term effects on the tibialis anterior motor activity during sleep in childhood?
### Response:
| The association between IDA in infancy, despite iron therapy, and PLMS in childhood could lead to new research in this area. Indeed, transient infantile IDA, a common nutritional problem among human infants, may turn out to be important for understanding the mechanisms of PLMS or restless legs syndrome, which are common in adulthood. |
### Instruction:
Do human Vdelta1 gamma-delta T cells exert potent specific cytotoxicity against primary multiple myeloma cells?
### Response:
| We have shown for the first time that Vδ1 T cells are highly myeloma-reactive and have therefore established Vδ1 γδ T cells as a potential candidate for a novel tumor immunotherapy. |
### Instruction:
Do neighbourhood satisfaction and happiness but not urbanization level affect self-rated health in adolescents?
### Response:
| Future public health intervention should attend to neighbourhood satisfaction and happiness for youth. |
### Instruction:
Is ultrasonography a potent tool for the prediction of progressive joint destruction during clinical remission of rheumatoid arthritis?
### Response:
| PD-US detects synovitis causing joint destruction even when the patient is in clinical remission. Thus, remission visible on US is essential to reach "true remission" of RA. |
### Instruction:
Does bone marrow-derived fibroblast growth factor-2 induce glial cell proliferation in the regenerating peripheral nervous system?
### Response:
| We conclude that FGF-2 secreted by BMMC strongly increases early glial proliferation, which can potentially improve PNS regeneration. |
### Instruction:
Does inhibition of phosphodiesterase type 3 dilate the rat ductus arteriosus without inducing intimal thickening?
### Response:
| Because PDE3 inhibitors induced longer-lasting vasodilation without causing apnea or HA-mediated IT, they may be good alternatives to PGE(1) for patients with DA-dependent CHD. |
### Instruction:
Is ischemia and reperfusion liver injury reduced in the absence of Toll-like receptor 4?
### Response:
| Both TLR4 bone marrow-derived and non-bone marrow-derived cells are necessary in the initial process of hepatic injury. Activating TLR4-dependent signaling is required for IRI. The absence of the TLR4 gene plays a pivotal role in reducing hepatic IR injury. |
### Instruction:
Is axon reflex-related hyperemia induced by short local heating reproducible?
### Response:
| Single-point LDF is a reproducible technique of assessing AR flare on volar surface of the forearm when the heating period is reduced to 5 min and the recording sites are fixed. Using this new protocol, short-heating LTH has a potential to be used to evaluate the effects of acute physical or chemical interventions between two short-heating LTH tests to further explore the pathophysiological meaning of heating-induced AR flare. |
### Instruction:
Is [ Indian Hedgehog signaling involved in the stretch induced proliferation of osteoblast ]?
### Response:
| The induced proliferation of osteoblasts by mechanical stretched is mediated at least in part by Indian Hedgehog (Ihh) signaling. |
### Instruction:
Does rheumatoid factor determine structural progression of rheumatoid arthritis dependent and independent of disease activity?
### Response:
| The data reveal that damage progression in seropositive RA patients is related to higher levels of disease activity and to independent effects of RF, particularly on bone damage. This calls for consideration of RF status irrespective of disease activity. |
### Instruction:
Is suppression of the basophil response to allergen during treatment with omalizumab dependent on 2 competing factors?
### Response:
| The basophil response during treatment with omalizumab is a consequence of 2 competing factors: suppression of allergen-specific IgE on the cell surface versus increased intrinsic sensitivity to IgE-mediated stimulation. In subjects with peanut allergy, the basophil response appears to mitigate against the ability of omalizumab to improve the patient's tolerance of oral allergen. |
### Instruction:
Is suppression of plasma estrogen levels by letrozole and anastrozole related to body mass index in patients with breast cancer?
### Response:
| The suppressed levels of plasma estradiol and estrone sulfate in postmenopausal women with early ER-positive breast cancer treated with the AIs anastrozole and letrozole are related to BMI. |
### Instruction:
Is heart rate time irreversibility impaired in adolescent major depression?
### Response:
| This study revealed the impaired heart rate asymmetry pattern indicating an altered complexity of cardiac autonomic regulation in adolescent female patients suffering from MDD. |
### Instruction:
Do mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture?
### Response:
| In an inflammatory environment, MSCs secrete factors which cause multiple anti-inflammatory effects and influence matrix turnover in synovium and cartilage explants. Thereby, the presented data encourage further study of MSCs as a treatment for joint diseases. |
### Instruction:
Does endothelin-1 stimulate human trophoblast cell migration through Cdc42 activation?
### Response:
| ET-1 stimulates EVT migration through Cdc42 activation. |
### Instruction:
Is transforming growth factor β-induced peritoneal fibrosis mouse strain dependent?
### Response:
| There were significant differences in mouse strain susceptibility to peritoneal fibrosis, suggesting that genetic factors may play a role in the development of peritoneal fibrosis and possibly EPS. As early TGFβ1 signaling mechanisms appear to be intact, we hypothesize that fibrosis resistance in the SJL/J mice lies further down the wound-healing cascade or in an alternate, non-SMAD pathway. |
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