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### Instruction:
Do neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction?
### Response:
| Neutrophil SPs induce a pro-adhesive phenotype in glomerular endothelium primarily by inducing neutrophil and platelet adhesion that transits to dysfunction after high/prolonged exposures. Dysregulated release of these enzymes within glomeruli may contribute to injury during diseases such as VGN. |
### Instruction:
Does histological loss of pancreatic exocrine cells correlate with pancreatic exocrine function after pancreatic surgery?
### Response:
| Pancreatoduodenectomy induced pancreatic exocrine insufficiency more frequently than DP. Histological loss of acinar cells in the pancreatic stump was strongly correlated with postoperative pancreatic exocrine function. |
### Instruction:
Does intraoperative colonoscopy facilitate safe dissection of the rectal pouch in a case of male imperforate anus?
### Response:
| IOC can be used to exclude RUF and facilitate safe dissection of the RP in imperforate anus. |
### Instruction:
Are serum uric acid levels associated with polymorphism in the SAA1 gene in Chinese subjects?
### Response:
| The rs12218 SNP in the SAA1 gene was associated with SUA levels in Chinese subjects, indicating that carriers of the T allele of rs12218 have a high risk of hyperuricemia. |
### Instruction:
Are viral kinetics associated with changes in cytokines and chemokines in serum and target organs of SSM-CVB3-infected macaques?
### Response:
| The results indicate that patterns of cytokine and chemokine response are associated with viral kinetics in the serum and target organs of SSM-CVB3-infected macaques, suggesting that the changes in cytokines and chemokines could help further our understanding of the progress of CVB3 infections in clinical settings. |
### Instruction:
Are wealth status , mid upper arm circumference ( MUAC ) and antenatal care ( ANC ) determinants for low birth weight in Kersa , Ethiopia?
### Response:
| The incidence of LBW was high in Kersa. Babies born to women who were poor, undernourished, experienced physical violence during pregnancy and who had poor access to health services were more likely to be LBW in this part of the country. In this largely poor community where ANC coverage is low, to reduce the incidence of LBW, it is essential to improve access for maternal health care. The involvement of husbands and the community at large to seek collective action on LBW is essential. |
### Instruction:
Do patients with persistent pain after breast cancer surgery show both delayed and enhanced cortical stimulus processing?
### Response:
| These results show that treatment and persistent pain have opposite effects on cortical responsiveness. |
### Instruction:
Is array-based comparative genomic hybridization more informative than conventional karyotyping and fluorescence in situ hybridization in the analysis of first-trimester spontaneous abortion?
### Response:
| aCGH analysis circumvents many limitations in traditional karyotyping or FISH. The accuracy and efficiency of aCGH in spontaneous abortions highlights its clinical usefulness for the future. As aborted tissues have the potential to be contaminated with maternal cells, the threshold value of detection in aCGH should be lowered to avoid false negatives. |
### Instruction:
Do hip- and knee-strength assessments using a hand-held dynamometer with external belt-fixation are inter-tester reliable?
### Response:
| The present study shows that isometric hip- and knee-strength measurements have acceptable inter-tester reliability at the group level, when testing strong individuals, using HHD with belt-fixation. This procedure is therefore perfectly suited for the evaluation and monitoring of strong athletes with hip, groin and hamstring injuries, some of the most common and troublesome injuries in sports. |
### Instruction:
Do circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction?
### Response:
| Circulating MPs can convert pCRP to pro-inflammatory mCRP in patients following MI, demonstrating for the first time mCRP generation in vivo and its detection in circulating blood. MPs can bind to cell membranes and transfer mCRP to the cell surface, suggesting a possible mCRP transport/delivery role of MPs in the circulation. |
### Instruction:
Do hot flushes and night sweats differ in associations with cardiovascular markers in healthy early postmenopausal women?
### Response:
| Hot flushes, but not night sweats, were associated with lower cardiovascular risk factors in these healthy postmenopausal women. Future research should differentiate night sweats from hot flushes. |
### Instruction:
Does immediately preoperative use of biological therapy influence liver regeneration after large resection -- porcine experimental model with monoclonal antibody against epidermal growth factor?
### Response:
| The achieved results of comparable liver regeneration in both the experimental and control groups confirms the use of biological treatment with cetuximab in the pre-operative period for minimizing the recovery period. |
### Instruction:
Does heat-processed ginseng enhance the cognitive function in patients with moderately severe Alzheimer 's disease?
### Response:
| These results demonstrate the potential efficacy of a heat-processed form of ginseng on cognitive function and behavioral symptoms in patients with moderately severe AD. |
### Instruction:
Does oxidation of the yeast mitochondrial thioredoxin promote cell death?
### Response:
| Mitochondrial Prx1 functions as a redox signaling molecule that oxidizes Trx3 and promotes apoptosis. This would mean that under conditions where Prx1 cannot detoxify mitochondrial ROS, it induces cell death to remove the affected cells. |
### Instruction:
Do a scoping study of one-to-one peer mentorship interventions and recommendations for application with Veterans with postdeployment syndrome?
### Response:
| This review supports the application in this population and proposes next steps for the development and systematic evaluation of PM interventions. |
### Instruction:
Does hilar GABAergic interneuron activity control spatial learning and memory retrieval?
### Response:
| Our findings establish a critical role for hilar GABAergic interneuron activity in controlling spatial learning and memory retrieval and provide evidence for the potential contribution of GABAergic interneuron impairment to the pathogenesis of amnesia in AD. |
### Instruction:
Is placental size associated with mental health in children and adolescents?
### Response:
| Compensatory placental growth may occur in response to prenatal insults. Such overgrowth may affect fetal development, including brain development, and ultimately contribute to psychopathology. |
### Instruction:
Does a novel mouse model of veno-occlusive disease provide strategies to prevent thioguanine-induced hepatic toxicity?
### Response:
| This novel model provides clinically relevant insights into how 6TG induces SOS, and how this dangerous adverse drug reaction may be avoided by either inhibition of endothelial activation or simple changes to dosing regimens of 6TG, while still being effective treatment for colitis. |
### Instruction:
Is static hyperinflation associated with decreased peak exercise performance in children with cystic fibrosis?
### Response:
| In children with cystic fibrosis, static hyperinflation and ventilatory limitation are associated with decrease in exercise performance, oxygen saturation, and P(aO(2)) during maximum cardiopulmonary exercise testing. All children with cystic fibrosis who exhibit static hyperinflation and ventilatory limitation may require S(aO(2)) monitoring during progressive exercise. |
### Instruction:
Are macular lutein and zeaxanthin related to brain lutein and zeaxanthin in primates?
### Response:
| An integrated measure of total macular pigment optical density, which can be measured non-invasively, has the potential to be used as a biomarker to assess brain lutein and zeaxanthin status. |
### Instruction:
Do colon cancer associated genes exhibit signatures of positive selection at functionally significant positions?
### Response:
| Identifying positive selection in the Primate, Hominidae, Muridae and Murinae lineages suggests an ancestral functional shift in these genes between the rodent and primate lineages. Analyses such as this, combining evolutionary theory and predictions - along with medically relevant data, can thus provide us with important clues for modeling human diseases. |
### Instruction:
Does inhibition of the placental growth factor decrease burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model?
### Response:
| The use of monoclonal antibodies targeting PlGF could thus offer a potential systemic treatment for patients who suffer from primary liver tumours. |
### Instruction:
Is medical comorbidities at admission predictive for 30-day in-hospital mortality in patients with acute myocardial infarction : analysis of 5161 cases?
### Response:
| Medical comorbidities were frequently found in patients with AMI. AMI patients with more comorbidities had a higher 30-day in-hospital mortality might be predictive of early poor outcome in patients with AMI. |
### Instruction:
Is tumour-free distance from serosa a better prognostic indicator than depth of invasion and percentage myometrial invasion in endometrioid endometrial cancer?
### Response:
| The TFD measure may be a more accurate method of representing myometrial invasion in the staging for endometrial cancer. |
### Instruction:
Do intramucosal bacterial microcolonies exist in chronic rhinosinusitis without inducing a local immune response?
### Response:
| Bacterial microcolonies are prevalent within paranasal sinus mucosa and are commonly S. aureus. These microcolonies do not provoke immune detection and may represent a phenotype that actively evades host immunity. This may underpin the recalcitrance of CRS to antibiotic therapy. These findings challenge classic views of both infection and mucosal immunity in human chronic disease. The presence of intramucosal bacteria in samples of normal sinus mucosa also questions the sensitivity of detecting nasal carriage of pathogens by swabbing the surface of the anterior nares. |
### Instruction:
Are oxidative damage , inflammation , and Toll-like receptor 4 pathway increased in preeclamptic patients : a case-control study?
### Response:
| The TLR4-NF-kB pathway is upregulated in PE, probably generating local and systemic inflammatory response that is followed by local and systemic oxidative damage. |
### Instruction:
Does reduced-dose docetaxel for castration-resistant prostate cancer have no inferior impact on overall survival in Japanese patients?
### Response:
| A reduced-dose regimen of docetaxel has no inferior impact on OS. Further studies on the optimal dose of docetaxel for Japanese patients are required. |
### Instruction:
Does provision of a soy-based intravenous lipid emulsion at 1 g/kg/d prevent cholestasis in neonates?
### Response:
| Lipid reduction to 1 g/kg/d does not prevent or delay the onset of cholestasis in neonates. |
### Instruction:
Does activation of transforming growth factor-β/Smad signaling reduce aggregate formation of mislocalized TAR DNA-binding protein-43?
### Response:
| Activation of the TGFβ/Smad signaling system is protective against aggregate formation of cytoplasmically mislocalized TDP-43 and may be a potential therapeutic approach to delay progression of ALS. |
### Instruction:
Do [ Epitopic multiple antigen peptide from α-fetoprotein elicit antitumor immune response in vitro and ex vivo ]?
### Response:
| AFP multiple antigen peptides elicit not only more powerful specific anti-tumor immune responses but also stronger non-specific anti-tumor immune activities than their corresponding linear peptides. These findings will provide theoretical rationales for their clinical applications. |
### Instruction:
Does [ Lingmao recipe inhibit starvation induced autophagy in HepG2.2.15 cell ]?
### Response:
| LR could inhibit starvation-induced autophagy in HepG 2.2.15. |
### Instruction:
Does tissue engineering approach to degenerative disc disease -- a meta-analysis of controlled animal trials?
### Response:
| Treatment of an injured/degenerating disc with cells, cells plus biomaterial or biomaterial alone has a potential for at least a partial regeneration of the disc. However, so far, none of the treatments is able to effectively restore the properties of a healthy disc. |
### Instruction:
Is age-associated increase in salt sensitivity accompanied by a shift in the atrial natriuretic peptide modulation of the effect of marinobufagenin on renal and vascular sodium pump?
### Response:
| Age-associated downregulation of cGMP/PKG-dependent signaling impairs the ability of ANP to modulate the effects of MBG on the sodium pump, which contributes to salt sensitivity. |
### Instruction:
Does pelvic morphology differ in rotation and obliquity between developmental dysplasia of the hip and retroversion?
### Response:
| Pelvic morphology is associated with acetabular pathomorphology. Our measurements, except the AIIS sign, are indirect indicators of acetabular retroversion. The data suggest they can be used when the acetabular rim is not clearly visible and retroversion is not obvious. |
### Instruction:
Is the matrix metalloproteinase 2-1575 gene polymorphism associated with the risk of developing myocardial infarction in Mexican patients?
### Response:
| The results suggest that the MMP2-1575 (rs243866) gene polymorphism could be involved in the risk of developing myocardial infarction in Mexican individuals. |
### Instruction:
Does expression of vascular endothelial growth factor-C in primary cutaneous melanoma predict sentinel lymph node positivity?
### Response:
| Our results, taking into account the expression of either VEGF-C or related histopathological markers, indicated the possibility to use VEGF-C immunohistochemistry as a marker of metastatic progression, especially in thin cutaneous melanomas. |
### Instruction:
Is tUFM a potential new prognostic indicator for colorectal carcinoma?
### Response:
| Increased expression of TUFM is a promising new prognostic indicator for CRC. Selective inhibition of TUFM in tumour cells may present a new avenue for the targeted therapy of this cancer. |
### Instruction:
Is higher plasma fractalkine associated with better 6-month outcome from ischemic stroke?
### Response:
| In contrast to our original hypothesis, lower concentrations of CX3CL1 are associated with worse stroke outcome. In light of recent studies suggesting an immunomodulatory and neuroprotective role for CX3CL1 in a variety of neurodegenerative diseases, a therapeutic role for CX3CL1 in stroke recovery should be considered. |
### Instruction:
Does cRF induce intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α?
### Response:
| These data demonstrate that CRF triggers increases in intestinal paracellular permeability via mast cell dependent release of TNF-α and proteases. Furthermore, CRF-mast cell signaling pathways and increases in intestinal permeability require critical input from the enteric nervous system. Therefore, blocking the deleterious effects of CRF may address the enteric signaling of mast cell degranulation, TNFα release, and protease secretion, hallmarks of IBS and IBD. |
### Instruction:
Is cervical intraepithelial neoplasia associated with genital tract mucosal inflammation?
### Response:
| HRHPV+ CIN is characterized by changes in soluble mucosal immunity that could contribute to HPV persistence. The observed mucosal inflammation suggests a mechanism that may also contribute to the epidemiologic link between persistent HPV and HIV. |
### Instruction:
Does neither neoadjuvant nor adjuvant therapy increase survival after biliary tract cancer resection with wide negative margins?
### Response:
| Early surgical resection of biliary tract malignancies with 1 cm tumor-free margins provides the best probability for long-term survival. Currently available neoadjuvant or adjuvant therapy does not improve survival. |
### Instruction:
Do antenatal depressive symptoms increase the likelihood of preterm birth?
### Response:
| In this large cohort of prenatally screened women, those with depressive symptoms had an increased likelihood of preterm birth. |
### Instruction:
Is six-minute walk distance related to quality of life in patients with non-cystic fibrosis bronchiectasis?
### Response:
| In this sample, there was a high proportion of patients who presented a lower than expected 6MWD. Although 6MWD was not related to QoL, it was associated with age and BMI. |
### Instruction:
Is treatment of Haemophilus bacteremia with benzylpenicillin associated with increased ( 30-day ) mortality?
### Response:
| Our results suggest that, after susceptibility testing, cefuroxime or aminopenicillins are preferable to benzylpenicillins as definitive therapy for Haemophilus bacteremia. |
### Instruction:
Do bony adaptation of the proximal humerus and glenoid correlate within the throwing shoulder of professional baseball pitchers?
### Response:
| The concurrent increases in dominant shoulder HRT and GRV were observed as a 2:1 "thrower's ratio." As this relationship was not observed on the nondominant shoulder, it suggests that bony adaptation of the proximal humerus and glenoid are coupled during skeletal development in the throwing shoulder. Longitudinal studies are needed to confirm this hypothesis. |
### Instruction:
Does a microRNA-7 binding site polymorphism in HOXB5 lead to differential gene expression in bladder cancer?
### Response:
| HOXB5 is overexpressed in bladder cancer. A miRNA-binding SNP (1010A/G) located within 3'-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer. |
### Instruction:
Does cryptorchidism-induced CFTR down-regulation result in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2?
### Response:
| Our results suggest that CFTR may be involved in regulating testicular TJs and the blood-testis barrier (BTB) through its negative regulation of the NF-κB/COX-2/PGE(2) pathway in Sertoli cells, a defect of which may result in the spermatogenesis defect in cryptorchidism. |
### Instruction:
Does prolonged hyperoxia preconditioning attenuate behavioral symptoms of 6-hydroxydopamine-induced Parkinsonism?
### Response:
| Our findings show that the prolonged hyperoxia preconditioning attenuates the behavioral symptoms of 6-OHDA-induced Parkinsonism. Considering the well-known correlation between dopaminergic neuronal death in the substantia nigra and the behavioral symptoms of 6-OHDA-induced Parkinsonism, it could be speculated that the prolonged hyperoxia preconditioning induces the mechanisms that provide dopaminergic neuroprotection against Parkinsonism-induced toxins. |
### Instruction:
Does yoga training improve quality of life in women with asthma?
### Response:
| Yoga training improved quality of life in women with mild-to-moderate asthma and resulted in decreased parasympathetic and increased sympathetic modulation in response to an IFE. |
### Instruction:
Are hepatitis B Virus Genotype B and High Expression of Interferon Alpha Receptor β Subunit Associated With Better Response to Pegylated Interferon Alpha 2a in Chinese Patients With Chronic Hepatitis B Infection?
### Response:
| HBV genotype B and high expression of IFNAR2 in the liver of chronic hepatitis B patients are closely associated with better response to Peg-IFN-α-2a therapy in chronic hepatitis B disease. |
### Instruction:
Does population-based study reveal new risk-stratification biomarker panel for Barrett 's esophagus?
### Response:
| Low-grade dysplasia, abnormal DNA ploidy, and AOL can be used to identify patients with BE most likely to develop EAC or high-grade dysplasia. |
### Instruction:
Does β-Catenin regulate deiodinase levels and thyroid hormone signaling in colon cancer cells?
### Response:
| Deiodinases are at the interface between the β-catenin and the thyroid hormone pathways. Their synchronized regulation of intracellular T3 concentration is a hitherto unrecognized route by which the multiple effects of β-catenin are generated and may be targeted to reduce the oncogenic effects of β-catenin in intestinal cells. |
### Instruction:
Is plasma free choline a novel non-invasive biomarker for early-stage non-alcoholic steatohepatitis : A multi-center validation study?
### Response:
| Plasma fCh levels are closely related to the grade of liver steatosis and fibrosis, and predict NASH severity. Plasma fCh levels are therefore a potential diagnostic marker for early-stage NASH in clinical practice. |
### Instruction:
Does sUV on dual-phase FDG PET/CT correlate with the Ki-67 proliferation index in patients with newly diagnosed non-Hodgkin lymphoma?
### Response:
| For patients with newly diagnosed NHL, the significant correlation between the Ki-67 index and the SUV in this study suggests that dual-phase FDG PET/CT may be used as a noninvasive measurement of tumor proliferation. |
### Instruction:
Does cortical stimulation mapping and Wada result demonstrate a normal variant of right hemisphere language organization?
### Response:
| Results suggest that the Wada procedure is a valid measure for identifying right hemisphere language processing without any false lateralization found in the patients mapped with CSM (i.e., a positive Wada is 100% sensitive for finding right hemisphere language sites), and that the distribution of language sites is consistent across right hemisphere and left hemisphere language dominant patients, supporting the theory that right hemisphere language can occur as a normal variant of language lateralization. |
### Instruction:
Do helicobacter pylori infection and administration of non-steroidal anti-inflammatory drugs down-regulate the expression of gastrokine-1 in gastric mucosa?
### Response:
| Both Helicobacter pylori infection and long-term non-steroidal anti-inflammatory drug administration downregulate gastrokine-1 expression in the gastric mucosa, which may contribute to the gastric mucosal injuries induced by these two factors. |
### Instruction:
Is perihepatic lymph node enlargement a negative predictor of liver cancer development in chronic hepatitis C patients?
### Response:
| Patients with PLNE had a lower risk of HCC development than those without PLNE. This study may provide new insights into daily clinical practice and the pathophysiology of HCV-induced hepatitis and hepatocarcinogenesis. |
### Instruction:
Does a novel survival-based tissue microarray of pancreatic cancer validate MUC1 and mesothelin as biomarkers?
### Response:
| MUC1 and MSLN were superior to pathologic features and other putative biomarkers as predicting survival group. Molecular assays comparing cancers from short and long survivors are an effective strategy to screen biomarkers and prioritize candidate cancer genes for diagnostic and therapeutic studies. |
### Instruction:
Does chemerin regulate NK cell accumulation and endothelial cell morphogenesis in the decidua during early pregnancy?
### Response:
| Our data indicate that chemerin is up-regulated during decidualization and might contribute to NK cell accumulation and vascular remodeling during early pregnancy. |
### Instruction:
Are decreased lectin-like oxidized LDL receptor 1 ( LOX-1 ) and low Nrf2 activation in placenta involved in preeclampsia?
### Response:
| Decreasing LOX-1 expression in preeclamptic placenta may contribute to high oxLDL concentration, low Nrf2 activation, and low HO-1 expression. These findings provide novel insights into the crucial role of LOX-1 and Nrf2 in the pathogenesis of preeclampsia. |
### Instruction:
Is 17β-Hydroxysteroid dehydrogenase type 14 a predictive marker for tamoxifen response in oestrogen receptor positive breast cancer?
### Response:
| Using a highly specific validated antibody for immunohistochemical analysis of a large number of breast tumours, we have shown that tumoural expression levels of 17βHSD14 can predict the outcome of adjuvant tamoxifen treatment in terms of local recurrence-free survival in patients with lymph node-negative ER+ breast cancer. The results need be verified to confirm any clinical relevance. |
### Instruction:
Does genetic variation of SCNN1A influence lung diffusing capacity in cystic fibrosis?
### Response:
| These results suggest that genetic variation of the α-subunit of ENaC differentially affects the diffusing capacity response to exercise in patients with CF. |
### Instruction:
Is carotid inflammation unaltered by exercise in hypercholesterolemic Swine?
### Response:
| These results first demonstrate that aerobic exercise has no effect on carotid endothelial inflammatory markers and EDD in FH swine. Second, our findings indicate that CEU using VCAM-1-targeted MBs can detect inflammation in vivo, providing strong foundations for longitudinal studies examining the effect of therapeutic interventions on the inflammatory status of the endothelium. |
### Instruction:
Are personality traits of the five-factor model associated with effort-reward imbalance at work : a population-based study?
### Response:
| This study suggests that personality traits may predispose to and protect from work stress. |
### Instruction:
Is body mass index independently associated with increased aortic stiffness in a Brazilian population?
### Response:
| In conclusion, our study failed to provide evidence of a positive, blood pressure (BP)-independent association between obesity on aortic stiffness. Our data suggests that the previously reported finding of an association between obesity and aortic stiffness was probably confounded by the progressive increase in BP observed in obesity. |
### Instruction:
Is the Glasgow Blatchford score the most accurate assessment of patients with upper gastrointestinal hemorrhage?
### Response:
| The GBS accurately identifies patients with UGIH most likely to need hospital-based intervention and also those best suited for outpatient care. The EGBS seems promising but must be validated externally. No scoring system seems to accurately predict patients' 30-day mortality or rebleeding. ClinicalTrials.gov number, NCT01589250. |
### Instruction:
Is the combination of octreotide and midodrine superior to albumin in preventing recurrence of ascites after large-volume paracentesis?
### Response:
| The combination of midodrine and octreotide after LVP is not superior to albumin in delaying recurrence of ascites or preventing PCD in patients with cirrhosis. Outcomes appear to be worse in patients given octreotide and midodrine. ClinicalTrials.gov number, NCT00108355. |
### Instruction:
Does regular in situ simulation training of paediatric medical emergency team improve hospital response to deteriorating patients?
### Response:
| These results indicate that lessons learnt by ward staff during regular in situ team training led to significantly improved recognition and management of deteriorating in-patients with evolving critical illness. Integration of in situ simulation team training in clinical care has potential applications beyond paediatrics. |
### Instruction:
Does smartphone technology enhance newborn intubation knowledge and performance amongst paediatric trainees?
### Response:
| Bedside use of smartphones can enhance both knowledge of newborn intubation and improves procedural performance, including reducing the time to successfully intubate. Smartphones may have a useful role in bringing procedural skills training closer to the bedside. |
### Instruction:
Do intraoperative sclerotomy-related retinal breaks during 23-gauge pars plana vitrectomy?
### Response:
| Pars plana vitrectomy (23-gauge) is associated with a low incidence of sclerotomy-related retinal breaks and postoperative retinal detachments. Eyes with breaks are more likely to be phakic and without a preoperative posterior vitreous detachment. The presence of vitreomacular traction may be a risk factor for the development of intraoperative sclerotomy-related breaks. |
### Instruction:
Does combined use of etanercept and MTX restore CD4⁺/CD8⁺ ratio and Tregs in spleen and thymus in collagen-induced arthritis?
### Response:
| Taken together, our findings suggest that ENT/MTX may modify the abnormal T lymphocytes balance from central to peripheral lymphoid organs, which may partially, explained the mechanism of the combined administration. |
### Instruction:
Is fluoroquinolone exposure prior to tuberculosis diagnosis associated with an increased risk of death?
### Response:
| Among this patient population, FQ exposure before TB diagnosis was associated with an increased risk of death. These findings underscore the need for cautious use of FQs in persons with possible TB. |
### Instruction:
Do [ Quick identification of sun-dried and sulfur-fumigated angelicae sinensis radix by Fourier transform infrared spectroscopy ]?
### Response:
| The FTIS method combined with second derivative can be utilized to distinguish sun-dried and sulfur-fumigated Angelicae Sinensis Radix efficiently, conveniently and accurately, and provide a basis for identification and quality control of Angelicae Sinensis Radix. |
### Instruction:
Does tIGAR induce p53-mediated cell-cycle arrest by regulation of RB-E2F1 complex?
### Response:
| TIGAR mediates de-phosphorylation of RB and stabilisation of RB-E2F1 complex thus delaying the entry of cells in S phase of the cell cycle. Thus, TIGAR inhibits proliferation of cancer cells and increases drug-mediated tumour regression by promoting p53-mediated cell-cycle arrest. |
### Instruction:
Do tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer?
### Response:
| These results suggest that macrophages influence tumors, and tumors influence macrophages, and tumor-educated promote tumor progression. Tumor-educated macrophages may be a target for therapy of metastatic cancer. |
### Instruction:
Does eRK inhibition enhance TSA-induced gastric cancer cell apoptosis via NF-κB-dependent and Notch-independent mechanism?
### Response:
| PD98059 synergistically potentiates TSA-induced GC growth arrest and apoptosis by manipulating NF-κB and p21(WAF1/CIP1) independent of Notch. Therefore, concomitant administration of HDACIs and ERK1/2 inhibitors may be a promising treatment strategy for individuals with GC. |
### Instruction:
Does dipeptidyl peptidase-4 inhibitor improve neovascularization by increasing circulating endothelial progenitor cells?
### Response:
| Circulating EPC levels and neovasculogenesis were augmented by the DPP-4 inhibitor, sitagliptin and this effect was dependent on an eNOS-related pathway in a mouse model of hindlimb ischaemia. The results indicate that oral administration of sitagliptin has therapeutic potential as an inducer of vasculogenesis. |
### Instruction:
Does above-real-time training ( ARTT ) improve transfer to a simulated flight control task?
### Response:
| ARTT followed by criterion training improves performance on a visual-motor coordination task. We think that ARTT influences known facilitators of transfer, including similarity to the criterion task and contextual interference. |
### Instruction:
Does [ Storage at room temperature change cisatracurium onset time : a prospective , randomized , double-blind controlled study ]?
### Response:
| This study demonstrated that cisatracurium's storage at room temperature had no influence on its onset time. It provides an argument for the preservation of cisatracurium at room temperature for a period not exceeding 21 days. Monitoring the onset of curarization may increase the quality score of intubation. |
### Instruction:
Does l-Carnitine prevent the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease?
### Response:
| L-carnitine supplementation attenuates cardiac fibrosis by increasing prostacyclin production through arachidonic acid pathway, and may be a promising therapeutic option for HFpEF. |
### Instruction:
Do prescription dose and fractionation predict improved survival after stereotactic radiotherapy for brainstem metastases?
### Response:
| SRT/SRS for brainstem metastases is safe and achieves a high rate of local control. We found higher GPA as well as greater number of treatment fractions and higher prescription dose to be correlated with improved overall survival. Despite this approach, prognosis remains poor and distant intracranial control remains an issue, even in patients previously treated with WBRT. |
### Instruction:
Are polymorphisms of tumor-related genes IL-10 , PSCA , MTRR and NOC3L associated with the risk of gastric cancer in the Chinese Han population?
### Response:
| These results indicate the importance of four gastric cancer susceptibility polymorphisms of IL-10, NOC3L, PSCA and MTRR in the Chinese Han population, which could be used in the determination of gastric cancer risk in clinical practice. |
### Instruction:
Is high density lipoprotein positively correlated with the changes in circulating total adiponectin and high molecular weight adiponectin during dietary and fenofibrate treatment?
### Response:
| HDL is positively correlated with the changes in circulating adiponectin during dietary and fenofibrate treatment. |
### Instruction:
Does sLEDAI-2K Responder Index 50 capture 50 % improvement in disease activity over 10 years?
### Response:
| The SRI-50 is a valid responder index derived form SLEDAI-2K and is very helpful in identifying clinically important improvement in active laboratory descriptors in an efficient time. |
### Instruction:
Do [ Positron emission tomography plus VEEG in the localization of epileptic foci in negative-MRI interact epilepsy ]?
### Response:
| PET imaging is both sensitive and effective in the detection and localization of epileptogenic foci. Especially for MRI-negative cases, it is an indispensable tool of localizing epileptogenic foci. |
### Instruction:
Does use of a furosemide drip improve earlier primary fascial closure in the open abdomen?
### Response:
| FD use may remove excess volume; however, forced diuresis with an FD is not associated with an increased rate of primary closure after DCL. Further studies are warranted to identify ICU strategies to facilitate fascial closure in DCL. |
### Instruction:
Does ajuga iva aqueous extract improve reverse cholesterol transport in streptozotocin-induced diabetic rat?
### Response:
| In STZ-induced diabetic rats, A. iva improves reverse cholesterol transport by enhancing LCAT activity, leading to anti-atherogenic effects. |
### Instruction:
Does gastroretentive gabapentin ( G-GR ) formulation reduce intensity of pain associated with postherpetic neuralgia ( PHN )?
### Response:
| Once-daily G-GR 1800 mg was effective and well tolerated for the relief of pain in patients with postherpetic neuralgia. |
### Instruction:
Do specialized ambulatory anesthesia teams contribute to decreased ambulatory surgery recovery room length of stay?
### Response:
| The decreased PACU LOS for the study group's patients occurred despite the increased incidence of PONV. Ambulatory anesthesiologists contributed to decreased PACU LOS while practicing evidence-based anesthesia with regard to PONV and pain control. Ambulatory subspecialization may benefit institutions as a way to increase perioperative efficiency and improve surgeon and patient satisfaction. |
### Instruction:
Is the majority of dorsal spinal cord gastrin releasing peptide synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons?
### Response:
| The majority of dSC Grp is synthesized locally in dorsal spinal cord neurons. On the other hand, Nmb is highly expressed in pain- and itch-sensing DRG neurons. Our findings provide direct anatomic evidence that Grp could function locally in the dorsal spinal cord in addition to its roles in DRG neurons and that Nmb has potential roles in nociceptive and itch-sensitive neurons. These results will improve our understanding about roles of Grp and Nmb in mediating itch sensation. |
### Instruction:
Is postoperative morbidity an additional prognostic factor after potentially curative pancreaticoduodenectomy for primary duodenal adenocarcinoma?
### Response:
| According to the present findings, the development of postoperative complications may be an additional prognostic factor after potentially curative pancreaticoduodenectomy for primary duodenal adenocarcinoma. This emphasizes the need for centralization to high-volume centers where an appropriate postoperative care can be delivered. |
### Instruction:
Does monitoring breathing rate at home allow early identification of COPD exacerbations?
### Response:
| Respiratory frequency can be monitored daily at home in patients with COPD receiving domiciliary oxygen therapy. In these patients, breathing rate increases significantly days before they require hospitalization because of ECOPD. This may offer a window of opportunity for early intervention. |
### Instruction:
Do wedge volume and osteotomy surface depend on surgical technique for distal femoral osteotomy?
### Response:
| Bone geometry following DFO suggests that the medial biplanar closed-wedge technique simultaneously creates smaller wedge volume and larger bone surface areas compared to the lateral biplanar open-wedge and the uniplanar DFO techniques. The horizontal cuts of the biplane DFO techniques are positioned behind the trochlear area in better healing metaphysial bone, which further enhances bone healing potential. Although this idealized geometric view on bony geometry excludes all biological factors that influence bone healing, the current data confirm the general rule for osteotomy techniques: reducing the amount of slow gap healing and wedge volumes and simultaneously increasing the area of faster contact healing by larger bone surface areas may be beneficial for osteotomy healing. |
### Instruction:
Does social influence on clinical outcomes of patients with ovarian cancer?
### Response:
| Social attachment is associated with a survival advantage for patients with ovarian cancer. Clinical implications include the importance of screening for deficits in the social environment and consideration of support activities during adjuvant treatment. |
### Instruction:
Is high interstitial fluid pressure associated with tumor-line specific vascular abnormalities in human melanoma xenografts?
### Response:
| High IFP in A-07-GFP and R-18-GFP human melanoma xenografts was primarily a consequence of high blood flow resistance caused by tumor-line specific vascular abnormalities. |
### Instruction:
Are thyroid hormones involved in 5'-nucleotidase modulation in soluble fraction of cardiac tissue?
### Response:
| Taken together, these data reveal that TH can influence adenosine production by modulating 5'-nucleotidase activity and expression, which may contribute to the cardioprotective effect and the maintenance of cardiac function under TH privation. |
### Instruction:
Does nicotine-induced activation of soluble adenylyl cyclase participate in ion transport regulation in mouse tracheal epithelium?
### Response:
| This study indicates that nicotine binding to nAChR in mouse tracheal epithelium activates transepithelial ion transport involving adenylyl cyclase activity. This might be important for novel therapeutic strategies targeting epithelial ion transport mediated by the non-neuronal cholinergic system. |
### Instruction:
Does acid sphingomyelinase deficiency contribute to resistance of scleroderma fibroblasts to Fas-mediated apoptosis?
### Response:
| In conclusion, this study suggests that ASMase deficiency promotes apoptosis resistance and contributes to activation of profibrotic signaling in SSc fibroblasts. |
### Instruction:
Is age-related cataract associated with type 2 diabetes and statin use?
### Response:
| In this population, statin use was substantially higher in patients with type 2 diabetes and was associated with AR cataracts. Further long-term study is warranted to recommend monitoring of crystalline lenses in patients with type 2 diabetes benefiting from statins. |
### Instruction:
Is myopia progression in Chinese children slower in summer than in winter?
### Response:
| Myopia progression in summer months was approximately 60% of that seen in winter, and axial elongation was likewise significantly less in summer. It is unclear whether more time spent outdoors in summer vs. winter is a contributing factor, or the difference in progression rates is a result of "seasonal" variations in the intensity or amount of close work performed. These results indicate that studies of potential myopia treatment strategies should be at least 12 months in duration to take seasonal variations into account. |
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