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### Instruction:
Do the most frequent ED patients carry insurance and a significant burden of disease?
### Response:
| The top 1% of frequent users usually had adequate health insurance and primary care access but were burdened by chronic conditions and frequent hospital admissions. Such patients may require more extensive coordinated medical management to decrease ED utilization. |
### Instruction:
Does practical skills training influence knowledge and attitude of dental students towards emergency medical care?
### Response:
| The evaluation data clearly show the participants' needs to deal with topics of EMC within the curriculum of dentistry. The proposed course is able to change participants' attitudes towards EMC and its importance for their daily practice. The considerable enhancement of self-confidence in performing EMC-techniques might also lead to more willingness to manage emergency situations. |
### Instruction:
Does the expression of vascular endothelial growth factor in mast cells promote the neovascularisation of human pterygia?
### Response:
| The results suggest that mast cells have a function in the vascularisation of pterygia through the secretion of VEGF. |
### Instruction:
Is hypoxia induced changes in lung fluid balance in humans associated with beta-2 adrenergic receptor density on lymphocytes?
### Response:
| Lung water decreases with 17 h normobaric hypoxia are associated with changes in beta adrenergic receptor density on lymphocytes in healthy adults. |
### Instruction:
Does ectopic expression of MiR-125a inhibit the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF?
### Response:
| Decreased miR-125a was observed in both HCC tissues and cell lines, and associated with patients' aggressive pathologic features. Up-regulating miR-125a significantly inhibited the malignant phenotypes by repressing the expression of matrix metalloproteinase 11 (MMP11) and vascular endothelial growth factor A (VEGF-A) both in vitro and in vivo. Furthermore, miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues. Inhibiting miR-125a could increase both MMP11 and VEGF-A expression, and RNA interference targeting MMP11 or VEGF-A mRNA could rescue the loss of miR-125a functions. MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A. Up-regulation of miR-125a might be a promising approach and a prognostic marker for HCC. |
### Instruction:
Does sensing of fatty acids for octanoylation of ghrelin involve a gustatory G-protein?
### Response:
| This study provides the first evidence that α-gustducin is involved in the octanoylation of ghrelin and shows that the ghrelin cell can sense long- and medium-chain fatty acids directly. GPR120 but not GPR40 may play a role in the lipid sensing cascade of the ghrelin cell. |
### Instruction:
Does [ Investigation of the cases presenting to Dokuz Eylül University Hospital with tick bite ]?
### Response:
| There was no significant difference in removing ticks without damage between the health personnel and the patient or relatives (p=0.133). |
### Instruction:
Does asynchronous thoraco-abdominal motion contribute to decreased 6-minute walk test in patients with COPD?
### Response:
| Thoraco-abdominal asynchrony worsens early during 6MWT in subjects with moderate and severe COPD, and rib cage excursion at 3 min predicts poor walking capability. A pulmonary rehabilitation strategy devised to improve rib cage excursion may help improve exercise tolerance. |
### Instruction:
Does arsenic trioxide induce depolymerization of microtubules in an acute promyelocytic leukemia cell line?
### Response:
| The microtubules alterations found with As(2)O(3) treatment suggest that As(2)O(3) increases the depolymerized forms of tubulin in cells and that this is potentially due to arsenite's negative effects on spindle dynamics. |
### Instruction:
Is genetic interaction between NAT2 , GSTM1 , GSTT1 , CYP2E1 , and environmental factors associated with adverse reactions to anti-tuberculosis drugs?
### Response:
| The study findings provide evidence of the clinical impact of the interaction between pharmacogenetic variability and environmental factors on ADRs induced by anti-TB drug therapy. Predictive pharmacogenetic testing and a comprehensive clinical history would therefore be helpful for identification and careful monitoring of patients at high risk of this complication. |
### Instruction:
Does low serum neutrophil count predict a positive prostate biopsy?
### Response:
| An elevated neutrophil count may be a good indicator of a benign prostate biopsy. Men with a low neutrophil count and an increase of serum PSA should strongly be considered for biopsy. |
### Instruction:
Are markers of endothelial and platelet activation associated with high on-aspirin platelet reactivity in patients with stable coronary artery disease?
### Response:
| The high on-aspirin RPR as defined by PFA100® seems not to be due to increased thrombin activity as evaluated with ETP, sTF, F1+2 or D-dimer. The elevated levels of platelet count, ß-TG, TFPI and especially vWF might be explained by increased endothelial and platelet activation in these patients. |
### Instruction:
Does oxygen-charged HTK-F6H8 emulsion reduce ischemia-reperfusion injury in kidneys from brain-dead pigs?
### Response:
| The present study has demonstrated that in brain-dead pigs the perfusion of kidneys with oxygen-precharged HTK-perfluorohexyloctane emulsion results in significantly reduced inflammation, hypoxic injury, and apoptosis and cellular integrity and energy content are well maintained. Histologic examination revealed less tubular, vascular, and glomerular changes in the emulsion-perfused tissue compared with the HTK-perfused counterparts. The concept of perfusing organs with oxygen-precharged emulsion based on organ preservation media represents an efficient alternative for improved organ preservation. |
### Instruction:
Does alpha-band power in the left frontal cortex discriminate the execution of fixed stimulus during saccadic eye movement?
### Response:
| We conclude that absolute alpha power in the left frontal cortex discriminates the execution of the two stimulus presentation patterns during SEM. |
### Instruction:
Is novel procedure , SILSOID colectomy , a bridge between conventional and single-incisional laparoscopic colectomy?
### Response:
| SILSOID colectomy is safe and feasible and it can be used as an alternative to conventional LC. We consider this procedure to be a bridge between conventional LC and more advanced laparoscopic procedures, such as SILS. |
### Instruction:
Does capsule endoscopy examination identify different leading causes of obscure gastrointestinal bleeding in patients of different ages?
### Response:
| Capsule endoscopy examination not only shows potential diagnostic value for obscure gastrointestinal bleeding, but it also helps to identify the leading causes of obscure gastrointestinal bleeding in all age groups. |
### Instruction:
Does cD36 repression activate a multicellular stromal program shared by high mammographic density and tumor tissues?
### Response:
| CD36 simultaneously controls adipocyte content and matrix accumulation and is coordinately repressed in multiple cell types within tumor and high mammographic density stroma, suggesting that activation of this stromal program is an early event in tumorigenesis. Levels of CD36 and extent of mammographic density are both modifiable factors that provide potential for intervention. |
### Instruction:
Does corticosteroid treatment inhibit airway hyperresponsiveness and lung injury in a murine model of chemical-induced airway inflammation?
### Response:
| Early treatment with dexamethasone is important in order to reduce the airway hyperresponsiveness and inflammation caused by toxic alkylating mustards such as melphalan. |
### Instruction:
Do sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells?
### Response:
| These results highlight the anti-tumor promoting properties of β-tan and Sal A. These SL molecules isolated from two plant species native to the Middle East may provide opportunities for complementary medicine practices. |
### Instruction:
Is time of physical exercise practice after injury in cervical spinal cord-injured men related to the increase in insulin sensitivity?
### Response:
| Our results suggest that exercise was able to reduce fat mass and increase insulin sensitivity, decreasing plasma levels of risk factors in c-SCI subjects. |
### Instruction:
Do sensory neuro-immune interactions differ between irritable bowel syndrome subtypes?
### Response:
| Distinct patterns of immune dysfunction and interaction with sensory pathways occur in different patient groups and through different intracellular pathways. Our results indicate IBS patient subgroups would benefit from selective targeting of the immune system. |
### Instruction:
Does [ New compound NL-608 ( a nutlin analog ) induce apoptosis in human breast cancer MCF-7 cells ]?
### Response:
| NL-608 induces apoptosis in MCF-7 cells in vitro through inducing caspase 3 activity and death receptor-mediated signal pathway. |
### Instruction:
Does regorafenib induce rapid and reversible changes in plasma nitric oxide and endothelin-1?
### Response:
| These findings indicate that regorafenib induces a coordinated and reversible suppression of NO and stimulation of ET-1. Whether NO and ET-1 might predict therapeutic efficacy in these patients requires further study. |
### Instruction:
Does polysaccharide extracted from Rheum tanguticum prevent irradiation-induced immune damage in mice?
### Response:
| RTP1 has an obvious protective effects on damage in γ-ray radiated mice. |
### Instruction:
Does downregulation of MiR-93 expression reduce cell proliferation and clonogenicity of HepG2 cells?
### Response:
| Our results reveal an important contribution for miR-93 in hepatocarcinogenesis and suggest a role for TGFBR2 and ITGB8 dysregulation in this process. Thus,the use of synthetic inhibitor of miR-93 may prove to bea promising approach to liver cancer treatment. |
### Instruction:
Does renal function have an effect on cardiovascular mortality in patients with dilated cardiomyopathy?
### Response:
| We have demonstrated that renal function is a prognostic risk marker in patients with ischemic and nonischemic DCM. |
### Instruction:
Is malondialdehyde-modified low-density lipoprotein a useful marker to identify patients with vulnerable plaque?
### Response:
| Using angioscopy and quantitative colorimetry, elevated MDA-LDL was confirmed to be associated with thin-cap atheroma in CAD patients. |
### Instruction:
Is hospital treatment in residential care facilities a viable alternative to hospital admission for selected patients?
### Response:
| Hospital treatment in residential care is viable for most patients, including those with dementia and those who need palliative care support. This model of care offers a valuable geriatric service to residents who would prefer to avoid hospital transfers, with no difference in mortality or rehospitalization rates for those treated in residential care, but a significant reduction in length of care. |
### Instruction:
Is physical activity the key determinant of skeletal muscle mitochondrial function in type 2 diabetes?
### Response:
| Mitochondrial dysfunction is apparent only in inactive longstanding T2DM patients, which suggests that mitochondrial function and insulin resistance do not depend on each other. Prolonged exercise training can, at least partly, reverse the mitochondrial impairments associated with the longstanding diabetic state. |
### Instruction:
Does oxytocin administration to parent enhance infant physiological and behavioral readiness for social engagement?
### Response:
| Results are the first to demonstrate that OT administration to one attachment partner can have parallel effects on the other and underscore the role of OT in the cross-generation transmission of human social participation. Findings have translational implications for conditions associated with early risk for social-emotional growth, including autism and prematurity, without the need to administer drugs to young infants. |
### Instruction:
Is site-specific CpG methylation in the CCAAT/enhancer binding protein delta ( CEBPδ ) CpG island in breast cancer associated with metastatic relapse?
### Response:
| CCAAT/enhancer binding protein delta CpG island methylation is associated with metastasis in breast cancer. Detection of methylated CEBPδ genomic DNA may have utility as an epigenetic biomarker of primary breast carcinomas at increased risk of relapse and metastasis. |
### Instruction:
Is a short-term increase in cancer risk associated with daytime napping likely to reflect pre-clinical disease : prospective cohort study?
### Response:
| The effect of pre-clinical disease is a likely explanation for the short-term increased risk of breast and other cancers associated with daytime napping. |
### Instruction:
Do serum markers lactate dehydrogenase and S100B predict independently disease outcome in melanoma patients with distant metastasis?
### Response:
| The serum markers LDH and S100B were both found to be prognostic factors in melanoma patients with distant metastasis. Furthermore, complete metastasectomy had an independent favourable prognostic impact in particular for the patient subgroup with normal LDH and S100B values. |
### Instruction:
Does cD99 ligation induce intercellular cell adhesion molecule-1 expression and secretion in human gingival fibroblasts?
### Response:
| Our study has shown the involvement of CD99 ligation in the up-regulation of ICAM-1 expression and its secretion in gingival fibroblasts, which may be essential for better understanding of the pathogenesis of periodontal disease. |
### Instruction:
Does alendronate enhance osseous healing in a rat calvarial defect model?
### Response:
| Alendronate enhances the new bone formation by autogenous bone graft in the rat calvarial defect model suggesting that the inhibition of the osteoclastic activity allows an increased rate of bone apposition, which could be applicable to the inflammation-induced destruction of the periodontal tissues during disease. |
### Instruction:
Does voluntary wheel running selectively augment insulin-stimulated vasodilation in arterioles from white skeletal muscle of insulin-resistant rats?
### Response:
| RUN selectively improved insulin-mediated vasodilation in Gw 2As, in part through attenuated ET-1 sensitivity/production, an adaptation that was independent of changes in adiposity and may contribute to enhanced insulin-stimulated glucose disposal. |
### Instruction:
Do serum bile acids and leptin interact with glucose metabolism in patients with liver cirrhosis?
### Response:
| Our results suggest a substantial involvement of BA and leptin by improving postprandial glucose tolerance related to liver cirrhosis. |
### Instruction:
Are physical activity/fitness peaks during perimenopause and BMI change patterns associated with baseline activity/fitness in women : a longitudinal study with a median 7-year follow-up?
### Response:
| We concluded that the age-related longitudinal patterns in physical activity and fitness are not linear. Baseline activity and fitness levels are associated with BMI status during adulthood, but do not affect BMI change trajectory. |
### Instruction:
Are polymorphisms -1082 G/A and -819 C/T in the interleukin-10 gene associated with gout susceptibility in the Chinese Han male population?
### Response:
| IL-10 -1082 G/A and -819 C/T polymorphisms may not be associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population. |
### Instruction:
Is anxiety associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson 's disease patients?
### Response:
| We reported an association between nigrostriatal DAT availability deficits and anxiety symptoms in newly diagnosed, untreated PD patients. Our results suggest that hypofunction of the nigrostriatal dopaminergic system may represent one of the functional anomalies involved in anxiety in PD from the earliest stages of disease and irrespective of any therapy. |
### Instruction:
Do [ ICAM-1 469K/E gene polymorphisms increase the risk of gastric dysplasia ]?
### Response:
| ICAM-1 469K/E gene polymorphisms are significantly associated with the risk of gastric low-grade dysplasia, but not related with severe chronic atrophic gastritis in a population with high risk of gastric cancer in Linqu County, Shandong Province, China. |
### Instruction:
Does vitamin C attenuate Chronic Chlorpyrifos-induced Alteration of Neurobehavioral Parameters in Wistar Rats?
### Response:
| The study therefore showed that improvement in muscle AChE activity, glycogen concentration and reduced lipoperoxidation by vitamin C may be partly responsible for the mitigation of the chronic CPF-induced sensorimotor performance. |
### Instruction:
Are membrane-bound estrogen receptor-α expression and epidermal growth factor receptor mutation associated with a poor prognosis in lung adenocarcinoma patients?
### Response:
| Presence of mERα expression together with EGFR mutation was found to be an independent prognostic factor for survival in patients with lung adenocarcinoma, suggesting cross-talk between mERα and EGFR mutation. |
### Instruction:
Does mitochondrial superoxide anion overproduction in Tet-mev-1 transgenic mice accelerate age-dependent corneal cell dysfunctions?
### Response:
| These results suggest that mitochondrial oxidative stress with electron transport chain dysfunction can influence pathogenesis and progression of age-related corneal diseases, as well as generalized corneal aging acceleration. |
### Instruction:
Is cyst fluid carcinoembryonic antigen level predictive of invasive cancer in patients with intraductal papillary mucinous neoplasm of the pancreas?
### Response:
| Single center experience, small patient numbers, retrospective data collection. |
### Instruction:
Does single-injection femoral nerve block lack preemptive effect on postoperative pain and morphine consumption in total knee arthroplasty?
### Response:
| Patients who received FNB used for total knee arthroplasty consumed significantly less postoperative morphine and had significant relief of post-TKA pain on postoperative day 1 than those who did not have FNB. However, at follow-up we found no significant differences in these values between those receiving FNB before surgery and those receiving it after surgery. |
### Instruction:
Is childhood physical abuse associated with incident metabolic syndrome in mid-life women?
### Response:
| This is the first study to show that a history of childhood abuse, specifically physical abuse, is related to the development of metabolic syndrome in midlife women. |
### Instruction:
Is the effectiveness of a multidisciplinary QI activity for accidental fall prevention : staff compliance critical?
### Response:
| In our study we observed a substantial decrease in patient fall rates and an increase of staff compliance with a newly implemented falls prevention program. A systematized QI approach that closely involves, encourages, and educates healthcare staff at multiple levels is effective. |
### Instruction:
Is interleukin-1β gene associated with preeclampsia in Taiwanese?
### Response:
| Our data do not support a role of the interleukin-1β gene in the pathogenesis of preeclampsia in Taiwanese women. |
### Instruction:
Do toddlers and preschoolers consume more dietary fiber when high-fiber lunch items are served?
### Response:
| Data indicate that children are accepting of high fiber, novel lunch items, thus indicating that serving high fiber lunch items at child care may increase dietary fiber intake in children. |
### Instruction:
Do salidroside and tyrosol from Rhodiola protect H9c2 cells from ischemia/reperfusion-induced apoptosis?
### Response:
| The inhibition of the JNK signaling pathway is the key mechanism for the cytoprotective effect of SAL and TYR in IR-induced apoptosis. |
### Instruction:
Does lRP1-dependent endocytic mechanism govern the signaling output of the bmp system in endothelial cells and in angiogenesis?
### Response:
| Together, these data reveal a novel role for LRP1 in the regulation of Bmp4 signaling by regulating receptor complex endocytosis. In addition, these data introduce LRP1 as a critical regulator of vascular development. These observations demonstrate Bmper's ability to fine-tune Bmp4 signaling at the single-cell level, unlike the spatial regulatory mechanisms applied by other Bmp modulators. |
### Instruction:
Do synergistical toll-like receptors activated dendritic cells induce antitumor effects against carcinoembryonic antigen-expressing colon cancer?
### Response:
| Our results have proved that combined activation of TLRs can lead to better maturation status of DCs and also induce more effective antitumor immune responses against colon cancer, suggesting this may be a potential strategy to develop more powerful DC cancer vaccines. |
### Instruction:
Is platelet vitamin D receptor reduced in osteoporotic patients?
### Response:
| The lower VDR expression in osteoporotic could indicate a lower ability to respond to vitamin D, and could be the explanation of the increase in the PTH and decrease in the phosphorus levels in patients with respect to controls. |
### Instruction:
Are two patterns of cerebral metabolite abnormalities detected on proton magnetic resonance spectroscopy in HIV-infected subjects commencing antiretroviral therapy?
### Response:
| Two patterns of cerebral metabolite abnormalities were observed in HIV-infected subjects electively commencing cART. Greater inflammatory metabolite ratios (Cho/Cr and MI/Cr) associated with lower markers of peripheral immune markers (CD4+ lymphocyte count) in the FGM and lower neuronal metabolite ratios (NAA/Cho) associated with greater HIV viraemia in the RBG were present in HIV-infected subjects. |
### Instruction:
Does non-invasive mapping of the gastrointestinal microbiota identify children with inflammatory bowel disease?
### Response:
| Microbiome-based diagnostics can distinguish pediatric patients with IBD from patients with similar symptoms. Although this test can not replace endoscopy and histological examination as diagnostic tools, classification based on microbial diversity is an effective complementary technique for IBD detection in pediatric patients. |
### Instruction:
Is circannual temperature-related variation in hemoglobin A1c unlikely to affect its use as a diagnostic test for type 2 diabetes?
### Response:
| During the year of this study, there were substantial temperature fluctuations but HbA1c concentration was more stable than FPG in non-diabetic individuals. It is therefore unlikely that temperature-related variation in HbA1c could affect the use of HbA1c as a diagnostic test for type 2 diabetes, but could affect the use of HbA1c as a glycemia control test for diabetes. |
### Instruction:
Are cD40 , CD45 CTLA-4 levels elevated in healthy older adults?
### Response:
| We found increased expression levels of CD40 and CD45 levels in healthy older (age: 59.42 +/- 5.89) versus younger individuals (age: 30.32 +/- 2.29). CTLA-4 expression levels were also higher in older subjects, with no difference in CD28 expression levels between younger/older individuals. |
### Instruction:
Is financial stress associated with reduced treatment adherence in HIV-infected adults in a resource-rich setting?
### Response:
| These are the first data to show that pharmacy dispensing and clinic travel costs may affect treatment adherence in a resource-rich setting. Patients should be asked if financial stress is limiting their treatment adherence. |
### Instruction:
Does sex differences in the renal vascular response to angiotensin II involve the Mas receptor?
### Response:
| The impact of the masR on renal haemodynamics appears to be sexually dimorphic, with greater effects in female than male rats. However, the paradoxical effects of dual AT(2) R and masR blockade suggest that a greater understanding of the complex interactions between RAS components is required before the therapeutic opportunities of AT(2) R and/or masR stimulation can be advanced. |
### Instruction:
Does 14-3-3σ regulate β-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3β?
### Response:
| Our findings show for the first time that 14-3-3σ plays an important role in regulating mouse embryonic stem cell proliferation by binding and sequestering phosphorylated GSK-3β and enhancing Wnt-signaled GSK-3β inactivation. 14-3-3σ is a novel target for embryonic stem cell expansion. |
### Instruction:
Are serum biomarkers similar in Churg-Strauss syndrome and hypereosinophilic syndrome?
### Response:
| In patients with a history of asthma and sinusitis, distinguishing between ANCA-negative CSS and PDGFR-negative HES is difficult because of significant overlap in clinical presentation and biomarker profiles. |
### Instruction:
Is coalition of DNA polymorphisms of ApoB and ApoAI genes related with coronary artery disease in Kazaks?
### Response:
| Coalition 11 of the 4 loci polymorphisms of the ApoB and ApoAI genes was correlated with CHD in Kazaks, and perhaps the ratio of ApoAI/ApoB was the most diagnostic parameter related with CHD among all lipid parameters. CHD may also be associated with Coalition 5, and, perhaps, Coalition 3 may have been confirmed as a protection factor against CHD, if more samples were enrolled. |
### Instruction:
Do endogenous angiogenesis inhibitors prevent adaptive capillary growth in left ventricular pressure overload hypertrophy?
### Response:
| Up-regulation of angiogenesis inhibitors prevents adaptive capillary growth in pressure-overload hypertrophied myocardium. Therapeutic interventions aimed at inhibition of angiogenesis inhibitors are useful in maintaining capillary density and thereby preventing heart failure. |
### Instruction:
Is autonomic function , as self-reported on the SCOPA-autonomic questionnaire , normal in essential tremor but not in Parkinson 's disease?
### Response:
| Autonomic scores, particularly gastrointestinal, cardiovascular, urinary, and thermoregulatory were increased in patients with PD, as assessed by SCOPA-Aut. Patients with ET did not exhibit autonomic dysfunction, with the exception of sialorrhea. |
### Instruction:
Does cold-induced stress increase the intensity of Chlamydia genital infection in mice?
### Response:
| These results suggest that cold-induced stress induces the production of catecholamines, which may play a critical role in the modulation of the immune system leading to increased susceptibility and greater intensity of Chlamydia genital infection that could promote the development of complications. |
### Instruction:
Does hepatitis C virus viremia increase the incidence of chronic kidney disease in HIV-infected patients?
### Response:
| Compared with HIV-monoinfected patients, HIV-positive patients with chronic rather than cleared HCV infection were at increased risk of developing CKD, suggesting a contribution from active HCV infection toward the pathogenesis of CKD. |
### Instruction:
Does isoflurane attenuate blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice?
### Response:
| Two percent isoflurane can suppress post-SAH blood-brain barrier disruption, which may be mediated by sphingosine kinase 1 expression and sphingosine-1-phosphate receptor-1/3 activation. |
### Instruction:
Is warfarin-associated intracerebral hemorrhage inadequately treated at community emergency departments?
### Response:
| Treatment of warfarin-associated intracerebral hemorrhage in community emergency departments is often suboptimal and does not adhere to published guidelines. Treating coagulopathy aggressively before interhospital transfer may improve outcomes and warrants further investigation. |
### Instruction:
Do patients living in impoverished areas have more severe ischemic strokes?
### Response:
| We found that increasing community poverty was associated with worse stroke severity at presentation, independent of other known factors associated with stroke outcomes. Socioeconomic status may impact stroke severity via medication compliance, access to care, and cultural factors, or may be a proxy measure for undiagnosed disease states. |
### Instruction:
Is nitric oxide involved in light-specific responses of tomato during germination under normal and osmotic stress conditions?
### Response:
| As well as defective BL signalling, the differential NO-dependent responses of the 7B-1 mutant are probably associated with its high endogenous ABA concentration and related impact on hormonal cross-talk in germinating seeds. These data confirm that light-controlled seed germination and stress responses include NO-dependent signalling. |
### Instruction:
Do volatile organic compounds enhance allergic airway inflammation in an experimental mouse model?
### Response:
| Our results demonstrate that exposure to VOCs may increase the allergic immune response by interfering with DC function and by inducing oxidative stress and has therefore to be considerate as risk factor for the development of allergic diseases. |
### Instruction:
Does cyclin I correlate with VEGFR-2 and cell proliferation in human epithelial ovarian cancer?
### Response:
| Our results indicate that elevated expression of cyclin I and VEGFR-2 is likely to provide a proliferative advantage to the EOC cells, and that cyclin I may be linked with angiogenesis in EOC. Higher expression of VEGFR-2 is associated with more advanced disease. Further investigation of cyclin I in ovarian cancer is needed to evaluate if cyclin I may become a novel target for an anticancer therapy. |
### Instruction:
Is hepatoprotective potential of Tecomella undulata stem bark partially due to the presence of betulinic acid?
### Response:
| It can be concluded that, hepatoprotective potential of Tecomella undulata stem bark is partially due to the presence of betulinic acid. |
### Instruction:
Is non-alcoholic fatty liver disease an independent predictor for macroangiopathy in Japanese type 2 diabetic patients : a cross-sectional study?
### Response:
| NAFLD was associated with an increased prevalence of diabetic macroangiopathy and coronary heart disease in elderly patients. In addition, NAFLD is an independent predictor for diabetic macroangiopathy. These findings suggest that type 2 diabetic patients with NAFLD should be considered as a high risk group for developing macroangiopathy, even if macroangiopathy is not clinically detected. |
### Instruction:
Does dexamethasone induce germ cell apoptosis in the human fetal ovary?
### Response:
| We have demonstrated for the first time that in vitro exposure to high doses of DEX impairs human fetal oogenesis through an increase in apoptosis. These data are of high importance, and additional epidemiological studies are required to investigate the female fertility of those women who have been exposed to DEX during fetal life. |
### Instruction:
Does duration of well-controlled core temperature correlate with neurological outcome in patients with post-cardiac arrest syndrome?
### Response:
| TH maintained at target temperature of 33 °C ± 1 °C over 18 hours independently correlated with favorable neurological outcome. Therefore, stable core temperature control may improve neurological outcome of successfully resuscitated OHCA. |
### Instruction:
Is nELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells mediated via c-Jun N-terminal kinase pathway activation?
### Response:
| Thus, activation of the JNK pathway is necessary to mediate terminal osteogenic differentiation of Saos-2 osteosarcoma cells by rhNELL-1. Future studies will extend these in vitro mechanisms to the in vivo effects of NELL-1 in dealing with orthopaedic defects caused by skeletal malignancies or other aetiologies. |
### Instruction:
Is [ CD5 expression an adverse prognostic factor in diffuse large B-cell lymphoma ]?
### Response:
| CD5 expression is an adverse prognostic factor in DLBCL and it has more prognostic value in the condition of low IPI (0 ∼ 2). |
### Instruction:
Does the UCSD shortness of breath questionnaire have longitudinal construct validity in idiopathic pulmonary fibrosis?
### Response:
| These results support the validity of the UCSD to assess change in dyspnea over time in patients with IPF. |
### Instruction:
Does brain-derived neurotrophic factor enhance the contraction of intestinal muscle strips induced by SP and CGRP in mice?
### Response:
| These data clarified the excitatory effects of SP, ACh and bilateral effects of CGRP on gut motility of mice and confirmed an essential role of BDNF on accelerating gut motility by enhancing the excitatory effects of SP/CGRP. |
### Instruction:
Do [ Protective effects of N-acetylcysteine on cochlear damage occur in guinea pigs exposed to irradiation ]?
### Response:
| MDA and SOD may be involved in the pathogenesis of cochlear cell damage. And NAC protects the irradiated cochlear cell. |
### Instruction:
Does metadherin contribute to the pathogenesis of diffuse large B-cell lymphoma?
### Response:
| Our results suggest that MTDH contributes to the pathogenesis of DLBCL mediated by activation of Wnt/β-catenin pathway. This novel study may contribute to further investigation on the useful biomarkers and potential therapeutic target in the DLBCL patients. |
### Instruction:
Do adipose-derived mesenchymal stem cells ameliorate STZ-induced pancreas damage in type 1 diabetes?
### Response:
| Intravenuously injected ADSC can prevent STZ induced β-cell destruction and decrease blood glucose level. |
### Instruction:
Do thawed autologous peripheral blood stem cells require modified quantification methods for hematopoietic progenitor cell evaluation?
### Response:
| Avoiding cell washing in the flow cytometric method limited the overestimate of the CD34 percentage. Plating 500 thawed CD34 improved reliability of the results and allowed a better standardization of the assay. |
### Instruction:
Does polyvinyl alcohol hydrogel decrease formation of adhesions in a rat model of peritonitis?
### Response:
| In this experiment, PVA/CMC hydrogel reduced the amount of adhesions to the SWD and between viscera significantly with equal risk of abscess formation. |
### Instruction:
Is aging associated with a diminished axon reflex response to local heating on the gaiter skin area?
### Response:
| Physiological aging is associated with an altered initial axon reflex response to local heating in the supramedial malleolar skin. Further work is required to determine whether these changes are more pronounced in frail and dependent groups and whether they could explain the higher incidence of skin ulcerations in the supramedial malleolar skin associated with venous insufficiency and neuropathy. |
### Instruction:
Is a polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH ( FAAH C385A ) associated with emotional-motivational reactivity?
### Response:
| Our findings emphasize the bidirectionality and thorough examination of the eCB system's impact on emotional reactivity as a central endophenotype underlying various psychiatric disorders. |
### Instruction:
Is knee extensor torque of men with early degrees of osteoarthritis associated with pain , stiffness and function?
### Response:
| The concentric and eccentric knee extensor torque is significantly correlated with self-report symptoms of patients in initial stages of knee OA. Therefore, the strengthening of the quadriceps muscles, through concentric and eccentric exercise is indicated for these patients in order to minimize these symptoms. |
### Instruction:
Is upregulation of miR-650 correlated with down-regulation of ING4 and progression of hepatocellular carcinoma?
### Response:
| These data suggested that miR-650 is correlated with the pathogenesis of HCC and is involved in the HCC tumorigenesis process by inhibiting the expression of ING4. |
### Instruction:
Are hCV genotypes differently prone to the development of resistance to linear and macrocyclic protease inhibitors?
### Response:
| The high degree of HCV genetic variability makes HCV-genotypes, and even subtypes, differently prone to the development of PIs resistance-mutations. Overall, this can account for different responsiveness of HCV-genotypes to PIs, with important clinical implications in tailoring individualized and appropriate regimens. |
### Instruction:
Does pre-existing arteriosclerotic intimal thickening in living-donor kidneys reflect allograft function?
### Response:
| The present study demonstrated that mild arteriosclerotic vasculopathy in the donated kidney is an important pathological factor that reflects future impaired function of renal allografts from marginal donors. |
### Instruction:
Is computed tomography perfusion examination helpful in evaluating the extent of oropharyngeal and oral cavity cancer?
### Response:
| CTP shows promise in distinguishing benign and malignant processes, primarily by means of BF, BV and PS. |
### Instruction:
Do dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome?
### Response:
| Agents with α-2 AR agonistic action have an inhibitory effect on VTs in a rabbit model of long QT syndrome. Alpha-2 AR agonists, especially dexmedetomidine, may be a therapeutic choice for abnormal repolarization-related VTs that are resistant to conventional treatment. |
### Instruction:
Does antitachycardia pacing reduce appropriate and inappropriate shocks in children and congenital heart disease patients?
### Response:
| ATP is highly efficacious for VT in children and patients with CHD. In addition to reducing appropriate shocks, inappropriate shocks due to sinus or supraventricular tachycardia can be significantly reduced with ATP. |
### Instruction:
Does [ Inconsistency of the Epworth sleepiness scale result with the polysomnography findings in patients with sleep-disordered breathing ]?
### Response:
| The responses to the questions in the ESS may vary from individual to individual, depending on the socio-cultural and economic status. We believe, therefore, that a new Turkey-based questionnaire considering the lifestyle of our population would offer more useful information about sleep disordered breathing. |
### Instruction:
Does human pituitary tumor-transforming gene 1 overexpression reinforce oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells?
### Response:
| Our findings provide novel molecular insights into hPTTG1-induced senescence and identify a novel mechanism by which hPTTG1 promotes metastasis by regulating the senescence-associated microenvironment. |
### Instruction:
Does p2X7 signaling promote microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand?
### Response:
| FasL functions as a key component of an immunoreactive response loop by recruiting microglia to the lesion sites through a P2X(7)-dependent mechanism. The specific modulation of P2X(7)/FasL signaling and aberrant microglial activation could provide therapeutic benefits in acute and subacute phase of cerebral microembolic injury. |
### Instruction:
Does enhancement of 26S proteasome functionality connect oxidative stress and vascular endothelial inflammatory response in diabetes mellitus?
### Response:
| Early hyperglycemia enhances 26S proteasome functionality, not autophagy or unfolded protein response, through peroxynitrite/superoxide-mediated PA700-dependent proteasomal activation, which elevates NF- ĸB-mediated endothelial inflammatory response in early diabetes mellitus. |
### Instruction:
Does adenosine facilitate dormant conduction across cavotricuspid isthmus following catheter ablation?
### Response:
| Adenosine infusion can facilitate dormant conduction across CTI following catheter ablation. Persistent BDB can be achieved with additional ablation. Adenosine challenge with additional ablation may improve long-term clinical outcome. |
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