question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Does heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identify markers of metaplastic progression?
### Response:
| While markers such as clusterin are expressed in all phenotypic SPEM lineages, distinct patterns of upregulated genes including CFTR are present in murine metaplasia associated with inflammation, indicative of progression of metaplasia towards a more intestinalised metaplastic phenotype. |
### Instruction:
Is mesenteric arteries responsiveness to acute variations of wall shear stress impaired in rats with liver cirrhosis?
### Response:
| Arteries from cirrhotic rats showed an abolished responsiveness to acute variations in flow, which exposes the mesenteric endothelium to sudden variations in WSS. |
### Instruction:
Does novel survivin inhibitor YM155 elicit cytotoxicity in glioblastoma cell lines with normal or deficiency DNA-dependent protein kinase activity?
### Response:
| The novel survivin inhibitor YM155 elicits potent cytotoxicity in glioblastoma cells in vitro via DNA-PK-independent mechanisms. YM155 could be used as a new therapeutic agent for the treatment of human glioblastomas. |
### Instruction:
Are immune and inflammatory pathways involved in inherent bone marrow ossification?
### Response:
| The marrow explant model indicates the inflammatory and immune pathways to be an integral part of the osteogenesis process. |
### Instruction:
Do family experiences and pediatric health services use associated with family-centered rounds?
### Response:
| FCR are associated with higher parent satisfaction, consistent medical information, and care plan discussion, with no additional burden to health service use. Additional studies should assess FCR under different settings of care. |
### Instruction:
Does chlormadinone acetate suppress prostaglandin biosynthesis in human endometrial explants?
### Response:
| Our data suggest that CMA is a suppressor of COX-2 expression. Comparison with DEX revealed that progestin-specific activity of CMA may mainly be responsible for suppression of prostaglandin biosynthesis in human endometrium. |
### Instruction:
Are physicians ' attitudes about interprofessional treatment of chronic pain : family physicians considered the most important collaborators?
### Response:
| Interprofessional collaboration may be enhanced with continuing medical education that will bring together different healthcare professionals, enable them to exchange experiences and learn about their potential roles within a team. |
### Instruction:
Does cachexia but not obesity worsen the postoperative outcome after pancreatoduodenectomy in pancreatic cancer?
### Response:
| In pancreatic cancer, underweight but not obese patients have a poor outcome after pancreatoduodenectomy. This observation emphasizes the need for pre- and perioperative therapeutic improvements in the setting of pancreatic cancer-associated cachexia. |
### Instruction:
Does multifactorial risk factor intervention in patients with Type 2 diabetes improve arginine bioavailability ratios?
### Response:
| In patients with Type 2 diabetes, intensified risk factor management improves arginine bioavailability ratios. Duration of diabetes seems to be an important factor influencing the capacity of the global arginine bioavailability ratio improvement. |
### Instruction:
Do the effects of different articulate curvature of artificial disc on loading distribution?
### Response:
| The concave PE insert on the inferior side not only decreased loading concentration but had relatively low stress. Such a design may be applicable for artificial discs. |
### Instruction:
Does drug-related problems and factors influencing acceptance of clinical pharmacologists ` alert in a large cohort of neurology inpatients?
### Response:
| Clinical pharmacologists and pharmacists can play an important role in identifying DRPs among neurology inpatients. Their recommendations for optimising medication-safety are most likely to be accepted for regular prescriptions, prescriptions associated with an adverse drug event and high-risk drug combinations. |
### Instruction:
Is multimodal endovascular management of acute ischemic stroke in patients over 75 years old safe and effective?
### Response:
| Multimodal endovascular recanalization of acute ischemic stroke is a relatively safe treatment option in patients older than 75 years of age. Careful patient selection by clinical and radiographic inclusion criteria is necessary for the successful management of stroke in this age group. |
### Instruction:
Are between subjects variability in haemoglobin and dose associated with the erythropoiesis-stimulating agent used to treat anaemia in dialysis : a meta-analysis?
### Response:
| Between subject variability in haemoglobin and ESA dose in dialysis patients is not associated with the type of ESA, nor with the dosing interval or route of administration, except for higher dose requirements in PEG-EPO monthly administration relative to every 2 weeks or rHuEPO i.v. relative to s.c. |
### Instruction:
Is mycoplasma penetrans infection a potential cause of immunoglobulin A nephropathy : a new animal model?
### Response:
| We made a new IgAN animal model that will offer a new direction for IgAN research. The activation of inflammation factors was associated with the Mpe induction of IgAN. |
### Instruction:
Does targeting of mitochondrial reactive oxygen species production avert lipid-induced insulin resistance in muscle tissue from mice?
### Response:
| SkQ treatment reduced muscle mitochondrial ROS production and prevented HF-induced oxidative stress. Nonetheless, whole-body glucose tolerance, insulin-stimulated glucose uptake, muscle insulin signalling and mitochondrial function were not improved. These results suggest that HF-induced oxidative stress is not a prerequisite for the development of muscle insulin resistance. |
### Instruction:
Are 20-HETE-producing enzymes up-regulated in human cancers?
### Response:
| The present finding of elevated expression of CYP4A/F enzymes in human cancer tissue suggests that 20-HETE inhibitors and antagonists may be useful in the treatment of cancer. |
### Instruction:
Is kRAS mutation present in a small subset of primary urinary bladder adenocarcinomas?
### Response:
| KRAS mutations are present in a small subset of primary urinary bladder adenocarcinomas. Future clinical trials for treatment of bladder adenocarcinoma, employing targeted therapies similar to those used for treatment of colon cancer, may also benefit from the predictive implications of KRAS mutational testing. |
### Instruction:
Does cognitive-behavioural therapy reduce unwanted thought intrusions in generalized anxiety disorder?
### Response:
| This study could not clarify whether the demonstrated effect mediates other changes, or how it relates to other cognitive biases in GAD. |
### Instruction:
Does homozygous null mutation in ODZ3 cause microphthalmia in humans?
### Response:
| Our data highlight a role for ODZ3 in the early development of the human eye. |
### Instruction:
Is cardioembolic stroke frequent in late recurrence after transient ischemic attack?
### Response:
| The frequency of cardioembolic stroke did not decline as time after TIA passed. More than one quarter of AF patients had been asymptomatic before stroke, suggesting the need for repeated examinations to detect AF in patients with TIA of unknown etiology. |
### Instruction:
Is aT13148 a novel , oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity?
### Response:
| The clinical candidate AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 will now be assessed in a first-in-human phase I trial. |
### Instruction:
Does transcriptome analysis of Termitomyces albuminosus reveal the biodegradation of lignocellulose?
### Response:
| Data presented in this study indicated that T. albuminosus had the ability to degrade lignin, which made cellulose more easily degraded by the cellulase produced by fungus-growing termite. |
### Instruction:
Does regular exercise training reduce coronary restenosis after percutaneous coronary intervention in patients with acute myocardial infarction?
### Response:
| Regular ET contributes to a significant reduction in late luminal loss in the stented coronary segment in AMI patients. This effect was associated with increased exercise capacity and increased HDL-C. |
### Instruction:
Does `` Polarizing '' microplegia improve cardiac cycle efficiency after CABG for unstable angina?
### Response:
| Microplegia attenuates myocardial damage in UA, reduces transfusions, improves postoperative systo-diastolic function, and shortens hospitalization. |
### Instruction:
Do alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype?
### Response:
| Ex vivo studies indicate that alveolar macrophages derived from overweight/obese subjects with asthma are uniquely sensitive to leptin. This macrophage phenotype, in the context of higher levels of soluble leptin, may contribute to the pathogenesis of airway disease associated with obesity. |
### Instruction:
Is overweight a risk factor for surgical site infection following distal gastrectomy for gastric cancer?
### Response:
| Compared with patients of normal weight, overweight patients had a significantly higher risk of SSI after distal gastrectomy for cancer. |
### Instruction:
Do atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers?
### Response:
| The airway inflammatory response to inhaled LPS challenge is blunted in AA patients compared with that seen in HVs and accompanied by reductions in airway neutrophilia and inflammasome-dependent cytokine production. These factors might contribute to increased susceptibility to airway microbial infection or colonization in AA patients. |
### Instruction:
Does [ Analysis of surgical treatment result in 120 cases of Budd-Chiari syndrome ]?
### Response:
| The surgical treatment of BCS need to get accurate diagnosis and pathological classification firstly, then, to choose appropriate therapeutic strategies based on individual pathological classification. The BCS radical resection can be an alternative method in some particular pathological classifications and the cases who failed in interventional treatment. |
### Instruction:
Do serum lipids modify periodontal infection - C-reactive protein association?
### Response:
| This study suggests that the relation of periodontal infection to the systemic inflammatory condition is more complicated than previously presumed. The findings of this study suggest that the possible systemic effect of periodontal infection is dependent on serum lipid composition. |
### Instruction:
Do accuracy evaluation of surgical guides in implant dentistry by non-contact reverse engineering techniques?
### Response:
| The results of this research demonstrate accurate transfer of implant replica position by virtual implant insertion into a pre-operative cast and a post-operative cast obtained from impressioning. In previous studies the evaluation of the implant positions have required a post-surgical CT scan. With the indirect methods by laser scanning technique, proposed in the paper, this extra radiation exposure of the patient can be eliminated. |
### Instruction:
Does regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuate isoproterenol-induced acute myocardial injury in rats?
### Response:
| Our results suggested that matrine protects against isoproterenol-induced myocardial ischaemia via eNOS and ADMA pathway. |
### Instruction:
Does eP4 receptor signalling in immature B cells involve cAMP and NF-κB dependent pathways?
### Response:
| Modulation of the EP4 receptor on immature B lymphocytes provides important insight into the observed action of PGE2 and opens new possibilities for the development of therapies for autoimmune diseases, leukaemia and lymphomas. |
### Instruction:
Is interleukin-33 hepatoprotective during liver ischemia/reperfusion in mice?
### Response:
| The data suggest that IL-33 is an important endogenous regulator of hepatic I/R injury. It appears that IL-33 has direct protective effects on hepatocytes, associated with the activation of NF-κB, p38 MAPK, cyclin D1, and Bcl-2 that limits liver injury and reduces the stimulus for inflammation. |
### Instruction:
Does the number of wires for sternal closure have a significant influence on sternal complications in high-risk patients?
### Response:
| Particularly in high-risk patients, careful haemostasis should be done and eight or more wires should be used to avoid sternal complications. |
### Instruction:
Does cigarette smoking increase levels of retinol-binding protein-4 in healthy men with normal glucose tolerance?
### Response:
| Smoking may have effect on insulin sensitivity, which is correlated with retinol-binding protein-4. |
### Instruction:
Does lRP16 gene protect mouse insulinoma MIN6 cells against fatty acid-induced apoptosis through Akt/FoxO1 signaling?
### Response:
| LRP16 regulated insulin content and GSIS in MIN6 cells by ERK1/2 and Akt activated way. Meanwhile, LRP16 overexpression protected MIN6 cells from fatty acid-induced apoptosis by partially restoring Akt phosphorylation and inhibiting FoxO1 nuclear redistribution. Therefore, LRP16 played important roles not only in insulin content and GSIS but also in the antilipotoxic effect mediated by Akt/FoxO1 signaling. |
### Instruction:
Do serum uric acid levels correlate with atrial fibrillation in patients with chronic systolic heart failure?
### Response:
| Higher SUA level is associated strongly with AF in patients with CHF. SUA level can increase the sensitivity and specificity in predicting AF. |
### Instruction:
Are bRAF ( L597 ) mutations in melanoma associated with sensitivity to MEK inhibitors?
### Response:
| This study shows that cells harboring BRAF(L597R) mutants are sensitive to MEK inhibitor treatment, providing a rationale for routine screening and therapy of BRAF(L597R)-mutant melanoma. |
### Instruction:
Is longitudinal right ventricular function a better predictor of right ventricular contribution to exercise performance than global or outflow tract ejection fraction in tetralogy of Fallot : a combined echocardiography and magnetic resonance study?
### Response:
| In patients following TOF repair, echocardiographic and CMR descriptors of global RV systolic function are, at best, weak predictors of exercise tolerance. Longitudinal function of the RV, measured remotely from the RVOT, may be a more important determinant of exercise performance than global RVEF in patients with aneurismal RVOTs. |
### Instruction:
Does [ Molecular mechanism of hydroxyurea enhance K562 cell apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand ]?
### Response:
| HU enhanced K562 cell sensitivity to rsTRAIL is mediated by Ras-MEK-ERK signaling pathway. Expression of antiapoptotic proteins cellular Fas associated death domain protein-like interleukin-1 beta-convening enzyme inhibitory protein and cellular inhibitor of apoptosis protein-1 is also down-regulated during this process. These results may through light on the therapeutic study of human chronic myelogenous leukemia. |
### Instruction:
Does allele summation of diabetes risk genes predict impaired glucose tolerance in female and obese individuals?
### Response:
| We found that T2D genetic risk alleles cause an increased risk for IGT. This effect was not present in male, lean and insulin sensitive subjects, suggesting a protective role of beneficial environmental factors on the genetic risk. |
### Instruction:
Do cD4 T cells mediate cardiac xenograft rejection via host MHC Class II?
### Response:
| Taken together, our results show that CD4 T cells are both necessary and sufficient for acute cardiac xenograft rejection and that host MHC Class II is critical in this process. |
### Instruction:
Is graft survival better without prior surgery in cardiac transplantation for functionally univentricular hearts?
### Response:
| Heart transplantation without prior cardiac surgery in patients with a UH was associated with better graft survival and lower probability of AR. The effect of age is complex and time-dependent, with age affecting outcomes after 5 years. |
### Instruction:
Does berbamine exhibit potent antitumor effects on imatinib-resistant CML cells in vitro and in vivo?
### Response:
| Berbamine inhibited proliferation of K562-r cells both in vitro and in vivo. Berbamine-induced apoptosis in K562-r cells appeared to occur through a mechanism involving Bcl-2 family proteins, as well as mdr-1 mRNA and P-gp protein. Berbamine in combination with imatinib restored the chemo-sensitivity of K562-r cells to imatinib. Our findings suggest that berbamine may be useful in treating imatinib-resistant CML patients. |
### Instruction:
Does adenovirus-mediated expression of UHRF1 reduce the radiosensitivity of cervical cancer HeLa cells to gamma-irradiation?
### Response:
| These results provide the first evidence for revealing a functional role of UHRF1 in human cervical cancer cells as a negative regulator of radiosensitivity. |
### Instruction:
Does b-type natriuretic peptide enhance vasculogenesis by promoting number and functional properties of early endothelial progenitor cells?
### Response:
| BNP promotes vessel growth by increasing the number of endothelial progenitors and enhancing their functional properties. These provasculogenic properties of BNP could account for some of its beneficial effects in chronic heart failure patients and may be harnessed for the purpose of improving collateral formation in ischemic subjects. |
### Instruction:
Is atrio-pulmonary vein conduction delay during pulmonary vein isolation for atrial fibrillation related to vein anatomy , age , and focal activity?
### Response:
| The incidence of CD was highest in the left common and superior PVs, in older patients and in PVs with focal activity. PVs with CD required more ablation applications and a larger area of ablation around the ostia. These observations were not found during repeat procedures. |
### Instruction:
Do low coronary flow velocity and shear stress predict restenosis after sirolimus-eluting stent implantation?
### Response:
| Lowered coronary flow velocity and shear stress after sirolimus-eluting stenting may predict the risk of restenosis. |
### Instruction:
Does rosuvastatin protect against angiotensin II-induced renal injury in a dose-dependent fashion?
### Response:
| Our findings indicate that rosuvastatin dose- dependently ameliorates angiotensin II-induced-organ damage and almost completely prevents inflammation at the highest dose. The data implicate 3-hydroxy-3-methylglutaryl coenzyme A function in signaling events leading to target-organ damage. |
### Instruction:
Does acute atrial tachyarrhythmia induce angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles?
### Response:
| Rapid atrial pacing induces AT(1)-receptor-mediated oxidative stress in LV myocardium that is accompanied by impaired microvascular blood flow and cTn-I release. These findings provide a plausible mechanism for the frequently observed cTn-I elevation accompanied with typical angina pectoris symptoms in patients with paroxysmal AF and normal (non-stenotic) coronary arteries. |
### Instruction:
Do low-dose dobutamine stress echo to quantify the degree of remodelling after cardiac resynchronization therapy?
### Response:
| Low-dose DSE increases and unmasks LBBB-induced dyssynchronous motion, easing its detection. The degree of clinical and echocardiographic response correlated with the extent of peak SF seen during low-dose DSE. |
### Instruction:
Is the inhibitory effect of recent type 2 diabetes risk loci on insulin secretion modulated by insulin sensitivity?
### Response:
| The negative effects of the risk alleles on ss-cell function appear additive in subjects with low insulin sensitivity but not in subjects with high insulin sensitivity. Effective compensatory mechanisms may exist in subjects with high insulin sensitivity that limit the impact of these genes. |
### Instruction:
Does comprehensive clinical follow-up of late effects in childhood cancer survivors show the need for early and well-timed intervention?
### Response:
| The observation that over 50% of cancer survivors suffered from late effects during the short follow-up period and that a high frequency of endocrine late effects was present indicates the need for early and well-timed intervention of the survivors. |
### Instruction:
Does treatment with TNF-alpha or bacterial lipopolysaccharide attenuate endocardial endothelial cell-mediated stimulation of cardiac fibroblasts?
### Response:
| The findings of this study using endocardial endothelial cells (EECs) and neonatal cardiac fibroblasts demonstrate that pro-inflammatory cytokines cause altered secretion of paracrine factors by EECs and inhibit proliferation and lower collagen synthesis in fibroblasts. These changes may influence fibroblast response and extra cellular matrix remodeling in pathological conditions of the heart. |
### Instruction:
Is placement of pH probes during upper endoscopy : direct visualization accurate?
### Response:
| Placing pH sensors under direct visualization is accurate and reduces radiation exposure. |
### Instruction:
Is accumulation of excess visceral fat a risk factor for pancreatic fistula formation after total gastrectomy?
### Response:
| VFA is a better indicator for pancreatic fistula formation after total gastrectomy than is BMI. Lymph node dissection must be performed carefully, especially in patients with visceral fat accumulation during total gastrectomy with splenectomy. |
### Instruction:
Do cAP37-derived antimicrobial peptides have in vitro antiviral activity against adenovirus and herpes simplex virus type 1?
### Response:
| Unlike the antibacterial activity of this CAP37 domain, its antiviral activity is not fully dependent upon disulfide bond formation. Viral inhibition appears to result, in part, from disruption of the envelope and/or capsid. |
### Instruction:
Does aTG plus cyclosporine reduce all-cause mortality in patients with severe aplastic anemia -- systematic review and meta-analysis?
### Response:
| The combination of both drugs should be considered the gold standard only for patients with severe aplastic anemia. |
### Instruction:
Do adolescents with skin disease have specific quality of life issues?
### Response:
| The results of this study revealed the extent and nature of the impact of skin diseases on adolescents' HRQoL. A number of issues identified were specific to adolescents, highlighting the need for specific HRQoL assessment. |
### Instruction:
Are hypoechoic foci on EUS simple and strong predictive factors for neoplastic gallbladder polyps?
### Response:
| Retrospective review of selected patients from a tertiary medical center. |
### Instruction:
Does n-acetylcysteine-induced vasodilation involve voltage-gated potassium channels in rat aorta?
### Response:
| The vasodilatory effect of NAC may be explained at least partly by activation of voltage-gated K+ channels. |
### Instruction:
Does erythromycin improve gastric emptying half-time in adult cystic fibrosis patients with gastroparesis?
### Response:
| Gastroparesis occurs in patients with cystic fibrosis, even in patients with relatively preserved lung function and in those without cystic-fibrosis related diabetes. Macrolides may be an effective therapy in cystic fibrosis patients with gastroparesis when administered acutely or chronically. |
### Instruction:
Is blunt assault associated with failure of nonoperative management of the spleen independent of organ injury grade and despite lower overall injury severity?
### Response:
| BA is associated with FiNOM independent of severity of splenic injury. Despite an increasingly successful policy of NOM in all blunt splenic injuries, this does not apply for BA. BA should be an important factor considered when initial NOM is contemplated for blunt splenic injury because of the high failure rates compared with all other mechanisms. |
### Instruction:
Does pGC-1alpha expression decrease in the Alzheimer disease brain as a function of dementia?
### Response:
| Therapeutic preservation of neuronal PGC-1alpha expression promotes the nonamyloidogenic processing of amyloid precursor protein precluding the generation of amyloidogenic Abeta peptides. |
### Instruction:
Does prenatal lipopolysaccharide increase postnatal intestinal injury in a rat model of necrotizing enterocolitis?
### Response:
| Intestinal injury observed may be mediated via nitric oxide synthase dysregulation. |
### Instruction:
Does intraurethral stimulation for reflex bladder activation depend on stimulation pattern and location?
### Response:
| These data indicate the potential presence of two distinct pathways for reflex bladder activation within the urethra: a supra-T10 circuit initiated in the proximal and mid urethra that responds to lower and higher frequency stimuli, and a sacral circuit initiated in the mid and distal urethra that responds to higher frequency stimuli. This work suggests potential anatomical targets and stimulus patterns for clinical evaluations of peripheral nerve-based neuroprostheses for bladder control. |
### Instruction:
Does melatonin present in beer contribute to increase the levels of melatonin and antioxidant capacity of the human serum?
### Response:
| Melatonin present in the beer does contribute to the total antioxidative capability of human serum and moderate beer consumption can protect organism from overall oxidative stress. |
### Instruction:
Does decreased Glasgow Coma Scale score mandate endotracheal intubation in the emergency department?
### Response:
| This study suggests that it can be safe to observe poisoned patients with decreased consciousness, even if they have a GCS of 8 or less, in the ED. |
### Instruction:
Does paricalcitol reduce basal and lipopolysaccharide-induced ( LPS ) TNF-alpha and IL-8 production by human peripheral blood mononuclear cells?
### Response:
| The in vitro inhibition of transforming growth factor alpha and interleukin 8 by paricalcitol confirms the immunomodulatory properties of this vitamin D analogue. |
### Instruction:
Does decreased cerebrospinal fluid Abeta ( 42 ) correlate with brain atrophy in cognitively normal elderly?
### Response:
| Reduction in CSF Abeta(42), likely reflecting Abeta aggregation in the brain, is associated with brain atrophy in the preclinical phase of AD. This suggests that there is toxicity associated with Abeta aggregation before the onset of clinically detectable disease. Increases in CSF tau (and ptau(181)) are later events that correlate with further structural damage and occur with clinical onset and progression. |
### Instruction:
Do reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha?
### Response:
| ONOO- could induce a protective mechanism in HSC in early stages of liver injury. |
### Instruction:
Does aPOE genotype modulate the effect of serum calcium levels on cognitive function in old age?
### Response:
| In old age, APOE genotype modulates the association between serum calcium levels and cognitive function. High serum calcium levels associate with worse cognitive function, especially in APOE epsilon4 allele carriers, but not in carriers of the epsilon2 allele. |
### Instruction:
Does a lifetime psychiatric history predict a worse seizure outcome following temporal lobectomy?
### Response:
| These data indicate that a lifetime psychiatric history may be predictive of a worse postsurgical seizure outcome after an anterotemporal lobectomy. |
### Instruction:
Is sleep disturbance in haemodialysis patients closely related to depression?
### Response:
| Incorporating a standard assessment and eventually treatment of depressive symptoms into the care provided to haemodialysis patients might improve psychological well-being, insomnia and quality of life, and, consequently, reduce mortality risk in this population. |
### Instruction:
Does prevalence and correlate of poor medication adherence amongst psychiatric outpatients in southwestern Nigeria?
### Response:
| The majority of psychiatric outpatients in southwestern Nigeria had poor medication adherence. Our findings stressed the importance of patients' perception and social environment in determining treatment adherence and the necessity of educating the patient. Clinicians' attention to psychological barriers early in treatment may improve medication adherence and ultimately affect the course of illness. |
### Instruction:
Is prematurity associated with reduced insulin sensitivity in adulthood?
### Response:
| Contrary to our hypothesis, preterm birth was not associated with reduced insulin sensitivity in young adulthood. |
### Instruction:
Is intestinal vitamin D receptor required for normal calcium and bone metabolism in mice?
### Response:
| Intestinal VDR and vitamin D-regulated intestinal calcium absorption are critical for controlling whole-body calcium metabolism in growing mice. Normalizing intestinal calcium absorption and metabolism reveals essential roles for VDR in control of bone formation and renal control of serum 1,25(OH)2D and urinary calcium excretion. |
### Instruction:
Does a newly designed thorax support vest prevent sternum instability after median sternotomy?
### Response:
| The use of the Posthorax sternum vest shows a favourable outcome to prevent sternum instability after cardiac surgery. There was one reoperation in patients treated with this sternum vest compared to 16 in the control groups. |
### Instruction:
Is radial artery graft flowmetry better than saphenous vein on postero-lateral wall?
### Response:
| RA-CABG demonstrated better TTF and GFR results compared to SV-CABG. These data may contribute to explain the survival benefit of arterial revascularization already reported. |
### Instruction:
Do mDR1/P-gp and VEGF synergistically enhance the invasion of Hep-2 cells with multidrug resistance induced by taxol?
### Response:
| MDR1/P-pg may be a risk predictor for the invasion of laryngeal cancer. MDR1 knock down and VEGFR-2 inhibitor may be two promising treatment regiments for advanced laryngeal carcinoma patients with MDR and invasion/metastasis. |
### Instruction:
Is c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kappaB activity in peripheral blood mononuclear cells an independent determinant of insulin resistance in healthy individuals?
### Response:
| JNK1/2 activity in adipose tissue but not NF-kappaB activity in PBMCs is an independent determinant of insulin resistance in healthy individuals. |
### Instruction:
Do novices outperform experienced laparoscopists on virtual reality laparoscopy simulator?
### Response:
| Increased operating room experience and age were associated with worsening simulator performance. Several potential explanations for this trend are discussed, including lack of tactile and contextual feedback. Caution should be exercised when considering current virtual reality simulator technology as a measure of experience or ability among gynecologic surgeons. |
### Instruction:
Do [ Growth behavior of spiral ganglion explants on cochlear implant electrodes and their materials ]?
### Response:
| The biocompatibility of CI materials with spiral ganglion neurons was shown in this study, but it differs with different CI materials. Besides the material itself, the arrangement of the materials can affect the neurite extension. |
### Instruction:
Is cFTR a negative regulator of NFkappaB mediated innate immune response?
### Response:
| Our data suggest that CFTR is a negative regulator of NFkappaB mediated innate immune response and its localization to lipid rafts is involved in control of inflammation. |
### Instruction:
Does overexpression of cyclin E messenger ribonucleic acid in nasopharyngeal carcinoma correlate with poor prognosis?
### Response:
| Overexpression of cyclin E messenger ribonucleic acid showed an adverse prognostic significance, correlating with an advanced stage of nasopharyngeal carcinoma and a low overall survival rate. |
### Instruction:
Is neutrophil gelatinase-associated lipocalin a new and sensitive marker of kidney function in chronic kidney disease patients and renal allograft recipients?
### Response:
| NGAL should be investigated as a potential early, sensitive marker of kidney impairment/injury, which might provide an additional accurate measure of kidney impairment in CKD and among transplant recipients, particularly at advanced stages. |
### Instruction:
Does budesonide improve decreased airway conductance in infants with respiratory symptoms?
### Response:
| Treatment with inhaled budesonide for 6 weeks improved sGaw in young children with chronic cough or wheeze and bronchial obstruction. |
### Instruction:
Does antibiotic resistance mechanisms of Escherichia coli isolate from urinary specimens?
### Response:
| CTX-M enzymes were the dominant type of ESBLs in urinary isolates of E. coli, and ESBL-producing isolates frequently contained other antimicrobial resistance genes. More than half of the urinary E. coli isolates harboring CTX-M enzymes were within the phylogenetic group B2. |
### Instruction:
Does micro-environmental mechanical stress control tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells?
### Response:
| Our results provide detailed, quantitative insight into the role of micro-environmental mechanical stress in tumor spheroid growth dynamics, and suggest how tumors grow in confined locations where the level of solid stress becomes high. An important implication is that apoptosis via the mitochondrial pathway, induced by compressive stress, may be involved in tumor dormancy, in which tumor growth is held in check by a balance of apoptosis and proliferation. |
### Instruction:
Does r-568 reduce ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder ( CKD-MBD )?
### Response:
| Thus, R-568, with or without Ca, improved the biochemical abnormalities of hyperparathyroidism but with higher and lower calcium levels, respectively, compared with controls. However, R-568 + Ca had more dramatic improvement in bone volume, but more extraskeletal calcification than R-568 alone. This complexity demonstrates that treatment of one component of CKD-MBD may lead to undesirable effects on other components. |
### Instruction:
Is genetic variation in the transforming growth factor-beta1 gene associated with susceptibility to IgA nephropathy?
### Response:
| Our experimental data together with the meta-analysis suggest TGFB1 as an important candidate gene for further biological studies of IgA nephropathy and as a possible target for therapy. Our data also indicate a possibility of a gender effect in the genetic background of IgA nephropathy. |
### Instruction:
Is [ Suppression of murine EAE by triptolide related to downregulation of INF-gamma and upregulation of IL-10 secretion in splenic lymphocytes ]?
### Response:
| Tri is an effective drug in suppressing murine EAE. This suppression is supposed to be related to downregulation of INF-gamma and upregulation of IL-10 secretion in splenic lymphocytes. |
### Instruction:
Does measurement of uterine radiation exposure from lymphoscintigraphy indicate safety of sentinel lymph node biopsy during pregnancy?
### Response:
| The measured uterine dose of radiation from lymphoscintigraphy for SLNB was significantly less than the average daily background radiation. We conclude that lymphoscintigraphy does not expose the fetus to significant radiation and concern of radiation exposure should not preclude the use of SLNB during pregnancy. |
### Instruction:
Are higher maternal TSH levels in pregnancy associated with increased risk for miscarriage , fetal or neonatal death?
### Response:
| In a cohort of pregnant women without overt thyroid dysfunction, the risk of child loss increased with higher levels of maternal TSH. Maternal FT(4) concentrations and child loss were not associated. |
### Instruction:
Does dihydroartemisinin ( DHA ) induce caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells?
### Response:
| These results show for the first time that DHA can inhibit proliferation and induce apoptosis via caspase-3-dependent mitochondrial death pathway in ASTC-a-1 cells. Our work may provide evidence for further studies of DHA as a possible anticancer drug in the clinical treatment of lung adenocarcinoma. |
### Instruction:
Do transorbital penetrating head injury by a toilet brush handle?
### Response:
| Transorbital penetrating brain injuries are treated best by utilizing all up-to-date technical developments such as intraoperative CT-scanning to increase the safety in the management of such exceptional lesions with increased risk of immediate life-threatening intracranial bleeding. |
### Instruction:
Does neamine inhibit prostate cancer growth by suppressing angiogenin-mediated rRNA transcription?
### Response:
| We confirmed that ANG is a molecular target for cancer drug development and that blocking nuclear translocation of ANG is an effective means to inhibit its activity. Our results also suggested that neamine is a lead compound for further preclinical evaluation. |
### Instruction:
Does apo2L/TRAIL inhibit tumor growth and bone destruction in a murine model of multiple myeloma?
### Response:
| This is the first in vivo study that investigates the efficacy of recombinant Apo2L/TRAIL on myeloma burden within the bone microenvironment and associated myeloma-induced bone destruction. Our findings that recombinant soluble Apo2L/TRAIL reduces myeloma burden within the bone microenvironment and protects the bone from myeloma-induced bone destruction argue against an inhibitory role of osteoprotegerin in Apo2L/TRAIL-induced apoptosis in vivo and highlight the need to clinically evaluate Apo2L/TRAIL in patients with multiple myeloma. |
### Instruction:
Is memory performance related to amyloid and tau pathology in the hippocampus?
### Response:
| This study implicates both amyloid deposition and tau pathology in the hippocampus as an early and late cause of decline in memory function over time in AD. Memory performance appears to be specifically related to the amount of amyloid plaques, NFTs and NTs in the entorhinal cortex and hippocampus. |
### Instruction:
Is metabolic syndrome an independent risk factor for stroke and acute renal failure after coronary artery bypass grafting?
### Response:
| This study showed the clinical importance of metabolic syndrome with respect to postoperative stroke and acute renal failure in patients having coronary artery bypass grafting. Like many established risk factors for postoperative complications, metabolic syndrome should be recognized as a novel risk factor for adverse events. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.