question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Does fetal fibronectin in vaginal specimens predict preterm delivery and very-low-birth-weight infants?
### Response:
| Vaginal fetal fibronectin expression is an independent risk factor for preterm delivery and birth of very-low-birth-weight infants in symptomatic women with intact amniotic membranes and minimal cervical dilatation. |
### Instruction:
Does direct current reduce wound edema after full-thickness burn injury in rats?
### Response:
| Direct electric current has a beneficial effect in reducing wound edema after burn injury. |
### Instruction:
Do the periurethral glands significantly influence the serum prostate specific antigen concentration?
### Response:
| The greatest difference in median PSA levels that could be found between men with and without periurethral glands when using 3 different ultra-sensitive assays was 0.01 ng./ml., indicating that the periurethral glands do not have a clinically significant effect on serum PSA concentration after radical prostatectomy. Thus, a serum PSA level above the residual cancer detection limit following radical prostatectomy, even if obtained with a ultra-sensitive assay, reflects either malignant or benign residual prostatic tissue, rather than the presence of periurethral glands. |
### Instruction:
Do circulating red cells usually remain of host origin after bone marrow transplantation for severe combined immunodeficiency?
### Response:
| SCID patients successfully treated with allogeneic bone marrow transplantation typically fail to show circulating red cells of donor phenotype; this finding is in contrast to the universal presence of circulating donor red cells following successful bone marrow transplantation to treat hematologic malignancies and other diseases. The milder conditioning regimens typically given to patients with SCID, along with T-cell depletion and HLA mismatching, may play a role in this different outcome. It is not known whether the inability to find circulating red cells of donor origin is due to a failure to engraft donor pluripotent stem cells or a failure of engrafted donor stem cells to differentiate along the erythroid lineage. |
### Instruction:
Does ursodeoxycholic acid reduce protein levels and nucleation-promoting activity in human gallbladder bile?
### Response:
| Ursodeoxycholic acid strongly decreases levels of various proteins and nucleation-promoting activity in bile. |
### Instruction:
Is pancreatic thread protein mitogenic to pancreatic-derived cells in culture?
### Response:
| reg messenger RNA is expressed in acinar but not in beta-cell or ductal pancreatic cell lines. PTP/reg protein was mitogenic to both beta-cell and ductal cell lines but not to mature, nondividing islets. This supports the hypothesis that PTP/reg protein is an acinar cell-derived mediator of beta-cell growth and may be involved in modulating the duct-to-islet axis. |
### Instruction:
Does missense mutation in the pore region of HERG cause familial long QT syndrome?
### Response:
| We conclude that the Ile593Arg missense mutation in HERG is the cause of LQT in this family because it segregates with disease, its presence was confirmed in three ways, and it is not found in normal individuals. The Ile593Arg mutation may result in a change in potassium selectivity and permeability leading to a loss of HERG function, thereby resulting in LQT. |
### Instruction:
Does transient sympathovagal imbalance trigger `` ischemic '' sudden death in patients undergoing electrocardiographic Holter monitoring?
### Response:
| Autonomic dysfunction, as detected by a marked decrease in heart rate variability, is present in the period (5 min) immediately preceding the onset of the ST shift precipitating ischemic sudden death. These data suggest that sympathovagal imbalance may trigger fatal arrhythmias during acute myocardial ischemia, thus resulting in sudden death. |
### Instruction:
Does impaired pial arteriolar reactivity to hypercapnia during hyperammonemia depend on glutamine synthesis?
### Response:
| Loss of the blood flow response to hypercapnia during acute hyperammonemia is not due simply to swollen astrocyte processes passively impeding blood flow because extraparenchymal resistance arterioles also lose their reactivity selectively to hypercapnia. Lost reactivity depends on glutamine synthesis rather than on ammonium ions per se and may reflect indirect effects of astrocyte dysfunction associated with glutamine accumulation or possibly effects of glutamine on nitric oxide production. |
### Instruction:
Do [ A new application of MR tomography of the lung using ultra-short turbo spin echo sequences ]?
### Response:
| Using UTSE of the lung, MRT can produce images of good quality. Compared with CT, contrast is better with MRT, offering diagnostic advantages for MRT. |
### Instruction:
Is cardiomyocyte troponin T immunoreactivity modified by cross-linking resulting from intracellular calcium overload?
### Response:
| The evolution of the ischemic injury is accompanied by changes in troponin T immunoreactivity as a consequence of the calcium-dependent activation of both calpain proteolysis and transglutaminase cross-linking. |
### Instruction:
Does the lazaroid U74389G protect normal brain from stereotactic radiosurgery-induced radiation injury?
### Response:
| These results suggest that the lazaroid U74389G protects the normal brain from radiation injury produced by stereotactic radiosurgery. |
### Instruction:
Do fetal RhD genotyping in fetal cells flow sorted from maternal blood?
### Response:
| Noninvasive prenatal diagnosis of the fetal RhD genotype is feasible. Absence of amplification products in the reaction requires confirmation that fetal material is present. Improvements in fetal cell purity and yield should increase diagnostic accuracy, although the current protocol has a positive predictive value of 100% and a negative predictive value of 67%. |
### Instruction:
Does analysis of the priming activity of lipids generated during routine storage of platelet concentrate?
### Response:
| Lipids were generated during the routine storage of platelet concentrates that prime the NADPH oxidase, and they may play a role in the severe complications of transfusion therapy. Other non-lipid compounds, such as interleukin 8, that are generated in whole-blood platelets may also contribute to the observed priming activity of plasma. |
### Instruction:
Does thromboxane receptor blockade improve oxygenation in an experimental model of acute lung injury?
### Response:
| Thromboxane receptor blockade prevents the pulmonary hypertension and the decline in oxygenation seen in an experimental model of acute lung injury that mimics adult respiratory distress syndrome. |
### Instruction:
Does interleukin-1 receptor antagonist inhibit subcutaneous B16 melanoma growth in vivo?
### Response:
| Abrogation of IL-1 activity, in combination with other systemic therapies may prove useful in the treatment of melanoma. |
### Instruction:
Does the CYP2D6 genotype predict the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol?
### Response:
| The results show that the genotype for CYP2D6 is closely related to the oral clearances of perphenazine and zuclopenthixol. If this finding can be confirmed in a larger population, genotyping may become an important tool for the dosing of these two neuroleptic agents. |
### Instruction:
Does pentobarbital enhance cyclic adenosine monophosphate production in the brain by effects on neurons but not glia?
### Response:
| Pentobarbital enhances stimulated cAMP accumulation in cultured preparations from brain and fresh cortical slices. Neurons are required for this effect. Because cAMP modulates neuronal excitability, this effect of pentobarbital may be an important mechanism by which this anesthetic influences brain function. |
### Instruction:
Does thymopentin modulate Th1 and Th2 cytokine response and host survival in experimental injury?
### Response:
| The protective effect of Thy in this experimental model may be mediated by modulation of cytokine release. |
### Instruction:
Are stapled ileal pouch anal anastomoses safer than handsewn anastomoses in patients with ulcerative colitis?
### Response:
| The stapled technique for IPAA has fewer septic complications and results in fewer sepsis-related pouch excisions, in our hands, than the handsewn technique technique, for treating patients with ulcerative colitis. |
### Instruction:
Do neuroectodermal antigens persist in benign and malignant salivary gland tumor cultures?
### Response:
| This model cell system containing proliferative cells from several tumor types is consistent with a stem-cell theory of salivary gland tumor origin. Our data were not consistent with the bicellular or multicellular theory. We hypothesize a neuroectodermal origin for this group of apparently heterogeneous tumors. These cultured cells will be valuable for in-depth investigation of the loss of proliferation controls in benign and malignant tumors of the salivary gland. |
### Instruction:
Is the RoHar antigenic complex associated with a limited number of D epitopes and alloanti-D production : a study of three unrelated persons and their families?
### Response:
| The finding of alloanti-D in an RoHar r person supports the concept that the D characteristic of this phenotype is a partial D antigen, which is consistent with the presence of the limited number of D epitopes found in epitope mapping. As has been suggested for other partial D antigens, RoHar individuals should be regarded as D- for the receipt of blood, and pregnant RoHar women who have had D+ pregnancies should receive anti-D prophylaxis. |
### Instruction:
Does fat-induced ileal brake in the dog depend on peptide YY?
### Response:
| Fat-induced ileal brake depends on PYY. |
### Instruction:
Is primary sclerosing cholangitis associated with nonsmoking : a case-control study?
### Response:
| The odds of having primary sclerosing cholangitis was significantly decreased among current smokers. Concomitant ulcerative colitis does not fully explain the association between nonsmoking and primary sclerosing cholangitis. Smoking may exert its protective effect in a systemic, rather than colonic, manner. |
### Instruction:
Are p53 mutation and MDM2 amplification rare even in human papillomavirus-negative cervical carcinomas?
### Response:
| In contrast to data derived from cultured cervical carcinoma cell lines and primary sarcomas, these results indicate that p53 mutation and amplification of the MDM2 oncogene are rare even in HPV-negative primary cervical carcinomas. However, to the authors; knowledge, this is the first observation of MDM2 amplification in humans outside sarcomas and neuroepithelial tumors. |
### Instruction:
Does sertraline alter the beta-adrenergic blocking activity of atenolol in healthy male volunteers?
### Response:
| The results of this study demonstrate that sertraline does not alter the beta-blocking activity of atenolol. |
### Instruction:
Does concurrent spinal infusion of MK801 block spinal tolerance and dependence induced by chronic intrathecal morphine in the rat?
### Response:
| Chronic spinal MK801 attenuates tolerance to, and withdrawal from spinal morphine in a dose-dependent fashion, supporting the hypothesis that N-methyl-D-aspartate receptor activity plays a role in the reorganization of spinal function produced by chronic opioid receptor activation. Chronic intrathecal MK801 appears to sensitize the spinal cord to intrathecal morphine. |
### Instruction:
Is prostaglandin E2 production by endotoxin-stimulated alveolar macrophages regulated by phospholipase C pathways?
### Response:
| PGE2 production is intimately dependent on several phospholipases. Production is not only dependent on low-molecular-weight PLA2 cleavage of arachidonic acid from membrane phospholipids, but also by-products of PLC activation. PLC-dependent intracellular Ca-calmodulin signaling and protein kinase C activation provide significant modulation of PGE2 production. |
### Instruction:
Does peripheral joint laxity increases in pregnancy but correlate with serum relaxin levels?
### Response:
| Peripheral joint laxity is noted to increase as pregnancy progresses. The cause of this change is undetermined. |
### Instruction:
Does transferrin increase adherence of iron-deprived Neisseria gonorrhoeae to human endometrial cells?
### Response:
| Iron and transferrin increased attachment of N. gonorrhoeae to human endometrial cells. |
### Instruction:
Does recovery of apparent diffusion coefficient after ischemia-induced spreading depression relate to cerebral perfusion gradient?
### Response:
| The variation in the recovery time of transient ADC decreases in the ischemic periphery reflects the gradient of the tissue perfusion. Severely delayed recovery time after spreading depression is thought to represent the ischemic penumbra. |
### Instruction:
Is cigarette smoking correlated with the periventricular hyperintensity grade of brain magnetic resonance imaging?
### Response:
| Cigarette smoking was a weak but significant positive predictor of the PVH score and was independent of age, hypertension, and antihypertensive treatment. Lipid abnormalities were not related to the PVH score. |
### Instruction:
Does gastric intramucosal pH predict outcome after surgery for ruptured abdominal aortic aneurysm?
### Response:
| Gastric intramucosal pH is the most reliable indicator of adequacy of tissue oxygenation in patients with RAAA, suggesting that splanchnic ischaemia may have played an important role in determining survival. |
### Instruction:
Does growth hormone replacement in healthy older men improve body composition but not functional ability?
### Response:
| Physiologic doses of growth hormone given for 6 months to healthy older men with well-preserved functional abilities increased lean tissue mass and decreased fat mass. Although body composition improved with growth hormone use, functional ability did not improve. Side effects occurred frequently. |
### Instruction:
Is conization for cervical intraepithelial neoplasia followed by disappearance of human papillomavirus deoxyribonucleic acid and a decline in serum and cervical mucus antibodies against human papillomavirus antigens?
### Response:
| Human papillomavirus deoxyribonucleic acid was regularly eliminated and human papillomavirus antibody levels, especially local immunoglobulin A, declined after efficient treatment, suggesting that conization may be effective for treating the underlying human papillomavirus infection. |
### Instruction:
Does fluticasone propionate improve quality of life in patients with asthma requiring oral corticosteroids?
### Response:
| Health-related quality of life improved in patients with severe asthma following 16 weeks of treatment with fluticasone propionate, 1000 micrograms bid. These improvements were maintained during subsequent fluticasone propionate treatment over a 1-year period. |
### Instruction:
Do young patients with prostate cancer have an outcome justifying their treatment with external beam radiation?
### Response:
| Our results using strict biochemical endpoints are comparable to reported series of similarly staged men treated with prostatectomy. In addition, the patient age of less than 65 is not a prognostic factor for worse outcome after radiation therapy. Young patients with clinically organ-confined prostate cancer who are fully informed of their treatment options can be appropriately accepted for external beam treatment. |
### Instruction:
Is irinotecan an active agent in untreated patients with metastatic colorectal cancer?
### Response:
| Irinotecan has activity in the treatment of patients with metastatic colorectal cancer. Strict adherence to an antidiarrheal regimen of diphenhydramine/loperamide significantly reduced the incidence of diarrhea; the agent was thereafter well tolerated in the majority of patients. |
### Instruction:
Is glomerular dysfunction in the aging Fischer 344 rat associated with excessive growth and normal mesangial cell function?
### Response:
| In the Fischer 344 rat, mesangial cell Ca2+ signaling, contraction, and proliferation responsiveness are unchanged with aging. Continued growth is associated with the glomerulosclerosis of aging. |
### Instruction:
Is reexploration for bleeding a risk factor for adverse outcomes after cardiac operations?
### Response:
| These data indicate that meticulous attention to surgical hemostasis and possibly application of recently developed modalities designed to facilitate perioperative correction of coagulopathy could improve outcomes after cardiac operations. |
### Instruction:
Is pyruvate dehydrogenase inactivity responsible for sepsis-induced insulin resistance?
### Response:
| Activation of pyruvate dehydrogenase with dichloroacetate does not ameliorate the impairment of whole-body, insulin-stimulated glucose uptake in septic humans or rats, or reverse the specific defect in insulin-mediated skeletal muscle glucose uptake by septic rats. Therefore, the decreased pyruvate dehydrogenase activity associated with sepsis does not appear to mediate sepsis-induced insulin resistance during insulin-stimulated glucose uptake at either the whole-body or tissue level. |
### Instruction:
Are vascular endothelial growth factor and platelet-derived growth factor potential angiogenic and metastatic factors in human breast cancer?
### Response:
| Expression of VEGF and PDGF mRNAs detected by reverse transcriptase-polymerase chain reaction in breast tumors correlates with tumor-related characteristics of angiogenesis and metastatic potential. Analysis of these mRNAs by reverse transcriptase-polymerase chain reaction may be useful for assessing the biologic behavior of a breast tumor before surgical treatment. |
### Instruction:
Does linkage analysis identify gene carriers among members of families with hereditary nonpolyposis colorectal cancer?
### Response:
| Linkage analysis can differentiate gene carriers from non carriers. Colorectal cancer screening should be restricted to gene carriers. |
### Instruction:
Do cholecystokinin-A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid?
### Response:
| CCK-A receptors are involved in the induction of meal-like fullness and nausea associated with intraduodenal lipid and gastric distention. |
### Instruction:
Does bacteroides fragilis enterotoxin modulate epithelial permeability and bacterial internalization by HT-29 enterocytes?
### Response:
| B. fragilis enterotoxin was associated with HT-29 cell rounding and with augmented internalization of selected strains of enteric bacteria that were preferentially adherent on the exposed enterocyte lateral surface. |
### Instruction:
Do thallium perfusion defects predict subsequent cardiac dysfunction in patients with systemic sclerosis?
### Response:
| We conclude that patients with SSc who have significant thallium perfusion defects are at a significantly increased risk of developing subsequent cardiac disease or death. |
### Instruction:
Does impulsive aggression in personality disorder correlate with tritiated paroxetine binding in the platelet?
### Response:
| Reduced numbers of platelet 5-HT transporter sites may covary with life history of aggressive behavior in patients with personality disorder. This may represent another abnormality in 5-HT function in individuals with personality disorder and aggressive behavior. |
### Instruction:
Is the outcome for children with blunt trauma best at a pediatric trauma center?
### Response:
| Children with BT have a significantly better outcome at a DPTC; the outcome for children with PT does not differ. Successful nonoperative treatment of blunt abdominal injuries is more likely to occur at a DPTC than at adult trauma centers "with pediatric committment." Thus, children with blunt injuries should be taken to a DPTC, when available. |
### Instruction:
Does volume expansion increase right ventricular infarct size in dogs by reducing collateral perfusion?
### Response:
| Volume expansion preserved stroke volume during RV ischemia, independent of pericardial integrity. However, volume expansion in animals with an intact pericardium increased RV infarct size by twofold to threefold secondary to reduced periischemic collateral perfusion. This detrimental effect of volume expansion on infarct size was prevented by opening the pericardium. |
### Instruction:
Does preconditioning prevent postischemic dysfunction in aging heart?
### Response:
| Preconditioning transient ischemic stimulus significantly reduces postischemic dysfunction in adult but not in senescent hearts, whereas exogenous norepinephrine is able to mimic preconditioning in both adult and senescent hearts. Ischemic preconditioning induces an increase in norepinephrine release in adult but not in senescent hearts. Preconditioning induced by transient ischemic stimulus and norepinephrine was abolished by alpha-adrenergic receptor blockade in both adult and senescent hearts. Thus, our data demonstrate that preconditioning is absent in aging heart and is probably related to the reduction of norepinephrine release and alpha-adrenergic receptor stimulation in response to ischemic preconditioning. |
### Instruction:
Does prolonged survival follow resection of oesophageal SCC downstaged by prior chemoradiotherapy?
### Response:
| For squamous oesophageal tumours deep to the submucosa this is an extremely good survival. For the present, this form of therapy for SCC of the oesophagus appears capable of achieving results comparable to, or better than, those reported for 3-field lymphadenectomy. |
### Instruction:
Do nonrandom chromosome breakpoints at Xq26 and 2q33 characterize cemento-ossifying fibromas of the orbit?
### Response:
| The authors described new nonrandom breakpoints in fibroosseous lesions of the orbit, which can result from at least two different types of structural chromosomal aberrations. The identification of recurring breakpoints at Xq26 and 2q33 provides a new cytogenetic tumor marker for the identification of this tumor subtype. The sublocalization of breakpoints in this tumor should provide important information for the precise localization and characterization of genes involved in the histiogenesis of these lesions. |
### Instruction:
Does anti-CD 18 monoclonal antibody slow experimental aortic aneurysm expansion?
### Response:
| Treatment with anti-CD18 monoclonal antibody slows the expansion of AAA in this experimental model. The associated inflammatory process at day 14, as indicated by monocyte infiltration, is reduced, but this effect may be opposed by the presence of hypertension. Further evaluation of the role of leukocytes and adhesion molecules in the expansion of AAA is warranted. |
### Instruction:
Does incidence and correlate of tardive dyskinesia in first episode of schizophrenia?
### Response:
| Poor response to the treatment of a first episode of psychosis and, to a lesser extent, antipsychotic drug dose are important factors in the development of TD. This suggests that there may be a disease-related vulnerability to TD manifest with antipsychotic drug exposure. Potential pathophysiologic factors might include neurodevelopmentally induced structural neuropathologic characteristics, sensitization of nigrostriatal dopamine neurons, and the induction of glutamatergically mediated neurotoxic effects. |
### Instruction:
Is heart transplantation associated with an increased risk for pancreaticobiliary disease?
### Response:
| Pancreaticobiliary disease occurs 17.4 times (95% CI, 9.2 to 32.7 times) more frequently in patients receiving transplants than in the general population. It is a seldom recognized but apparently common complication of orthotopic heart transplantation that results in substantial morbidity and health care resource use. Further study is needed to ascertain why this condition occurs and how the risk for developing it can be reduced. |
### Instruction:
Does fluid resuscitation with deferoxamine hetastarch complex attenuate the lung and systemic response to smoke inhalation?
### Response:
| An iron chelator deferoxamine complexed to hetastarch, given after a severe smoke exposure, significantly attenuates the airway and the systemic inflammatory (oxidant) injury, indicating free iron release and subsequent increased oxidant activity to be a major etiologic factor. |
### Instruction:
Is phenylacetate an inhibitor of prostatic growth and development in organ culture?
### Response:
| In common with earlier studies, we found that PA inhibits prostatic growth; however, in our organ culture system, differentiation was also largely inhibited. These studies indicate that there may be a role for PA in treating BPH or in elucidating the mechanism by which it occurs since BPH apparently involves the neoformation of ductal-acinar tissue in aged men via mechanisms fundamentally similar if not identical to those in fetal prostatic development. |
### Instruction:
Does myometrial arginase activity increase with advancing pregnancy in the guinea pig?
### Response:
| These studies demonstrate that pregnancy increases myometrial arginase activity and that the presence of placenta or fetus is necessary for the maximal effect. |
### Instruction:
Does serum creatine kinase predict ectopic pregnancy?
### Response:
| Maternal SCK concentrations do not reliably predict EP. |
### Instruction:
Are changes in permeability of sheep 's lungs by oleic acid dose dependent?
### Response:
| The double-isotope technique of external monitoring of permeability changes to protein in the lungs was sensitive to pick up graded increments in leakage, related in a dose-dependent way to lung injury. |
### Instruction:
Do ferric ammonium citrate-cellulose paste for opacification of the esophageal lumen on MRI?
### Response:
| The results indicate that this product effectively opacifies the esophageal lumen in the majority of patients. We found that it is easy to use, is well tolerated, and does not produce artifacts. |
### Instruction:
Does effects of diclofenac eye drop on corneal epithelial structure and function after small-incision cataract surgery?
### Response:
| Administration of DfNa eye drops did not cause significant abnormalities in the corneal epithelial structure or function of patients who had undergone small-incision cataract surgery. Their safety for use in procedures such as excimer laser photorefractive keratectomy remains to be established. |
### Instruction:
Do kikuchi 's histiocytic necrotizing lymphadenitis associated with ruptured silicone breast implant?
### Response:
| Our findings indicate that silicone compounds may be associated with transient abnormal immune reactions and lend further support to the hypothesis that KD represents an exuberant T-cell-mediated immune response to a variety of nonspecific stimuli. |
### Instruction:
Does topical tretinoin ( retinoic acid ) improve early stretch marks?
### Response:
| Topical application of tretinoin significantly improves the clinical appearance of early, active stretch marks. The processes that are responsible for the clinical improvement remain unknown. |
### Instruction:
Is serum lactate predicted by anion gap or base excess after trauma resuscitation?
### Response:
| There is no correlation between lactate, base excess, and anion gap after initial resuscitation. Neither anion gap nor base excess was capable of predicting lactate; therefore, lactate must be directly measured. The lack of correlation of anion gap with base excess or lactate suggests the presence of unmeasured anions, an impairment in acid-base regulation after injury and resuscitation, or both. |
### Instruction:
Does tauroursodeoxycholic acid activate protein kinase C in isolated rat hepatocytes?
### Response:
| TUDCA might stimulate Ca(2+)-dependent hepatocellular exocytosis into bile in part by activation of alpha-PKC. |
### Instruction:
Does glycine prevent alcohol-induced liver injury by decreasing alcohol in the rat stomach?
### Response:
| Glycine minimizes alcohol-induced liver injury in vivo by preventing ethanol from reaching the liver by activating first-pass metabolism in the stomach. |
### Instruction:
Does mechanical stress eliminate the effects of plasma from patients with preeclampsia on endothelial cells?
### Response:
| Shear stress alters the effects of plasma on endothelial cells. This is an important caveat in the interpretation of previous static in vitro culture studies and may partially explain the dichotomy between in vitro studies and in vivo findings in preeclampsia. |
### Instruction:
Does high-dose human menopausal gonadotropin stimulation in poor responders improve in vitro fertilization outcome?
### Response:
| Poor responders do not benefit from high-dose hMG stimulation; their reproduction outcome is poor. |
### Instruction:
Is midluteal buserelin superior to early follicular phase buserelin in combined gonadotropin-releasing hormone analog and gonadotropin stimulation in in vitro fertilization?
### Response:
| Clinical pregnancy and live birth rates are better when buserelin acetate is started in the midluteal phase rather than the early follicle phase before hMG and hCG stimulation in preparation for IVF-ET. |
### Instruction:
Is lipopolysaccharide outer core a ligand for corneal cell binding and ingestion of Pseudomonas aeruginosa?
### Response:
| Corneal epithelial cells bind and internalized P. aeruginosa by the exposed LPS core. |
### Instruction:
Are salt taste perceptions and preferences unrelated to sodium consumption in healthy older adults?
### Response:
| Salt taste perceptions and preferences were unrelated to sodium intakes in young adults and in older respondents. Factors other than taste may influence dietary sodium consumption. |
### Instruction:
Are overexpression of p53 protein and DNA content important biologic prognostic factors for thyroid cancer?
### Response:
| Both positive staining for the p53 protein and DNA ploidy, which suggest biologic aggressiveness, are independent prognostic factors for overall survival of patients with thyroid cancer, Examination of these biologic factors may provide new information regarding postoperative recurrences and the prognosis of thyroid cancer. |
### Instruction:
Are impaired small intestinal peristaltic reflexes and sensory thresholds independent functional disturbances in patients with chronic unexplained dyspepsia?
### Response:
| Disturbed peristaltic reflexes and decreased sensory thresholds for perception of intestinal sensations are prevalent but may be independent abnormalities in patients with unexplained dyspepsia. |
### Instruction:
Is alcoholism associated with hepatitis C but not hepatitis B in an urban population?
### Response:
| The increased seroprevalence of hepatitis C in actively drinking alcoholic patients without known risk factors suggests that alcoholism, in some way, is a predisposing factor for HCV infection. |
### Instruction:
Does selective blockade of cholecystokinin type B receptors with L-365,260 impair gallbladder contraction in normal humans?
### Response:
| Multiple oral doses of L-365,260 do not alter ultrasonographically assessed gallbladder contraction at doses shown to be clinically effective in earlier studies. Despite being more difficult to implement, the sum of cylinders method for estimating gall bladder size offers no advantage over the ellipsoid method. |
### Instruction:
Do hyalocytes synthesize and secrete inhibitors of retinal pigment epithelial cell proliferation in vitro?
### Response:
| Hyalocyte-conditioned medium inhibits RPE cell proliferation in vitro through TGF-beta and at least one other molecule. Production of these factors by hyalocytes in vivo could provide a deterrent for epiretinal membrane formation that may be perturbed under pathologic conditions. |
### Instruction:
Does interferon alfa induce leukocyte capillary trapping in rat retinal microcirculation?
### Response:
| Interferon alfa increased leukocyte adherence to vascular endothelium and subsequent leukocyte trapping in the retinal capillaries. Interferon alfa may activate leukocytes, and activated leukocytes may be involved in the pathogenesis of microinfarction associated with interferon-induced retinopathy. |
### Instruction:
Do elevated progesterone levels in the late follicular phase predict success of in vitro fertilization-embryo transfer?
### Response:
| We conclude that in IVF-ET cycles, when pretreated with GnRH-a, P levels may increase on the day of hCG administration despite LH suppression and such elevation may not affect adversely the final outcome. |
### Instruction:
Do inhaled corticosteroids prevent the development of tolerance to the bronchoprotective effect of salmeterol?
### Response:
| Tolerance to the acute bronchoprotective effect of salmeterol was significant after the first two doses and persisted after the seventh dose. Tolerance to the acute bronchoprotective effect of salbutamol was also significant after regular use of salmeterol for seven doses. These effects, in subjects using inhaled corticosteroids regularly, were similar to the those previously seen in patients with mild asthma using as-required beta 2-agonists only, indicating that tolerance is not prevented by use of inhaled corticosteroids. |
### Instruction:
Do human follicular fluid and mouse cumulus cells act synergistically to enhance preimplantation mouse Balb/cJ embryo development?
### Response:
| Cumulus cells and follicular fluid have a positive synergistic affect on preimplantation mouse Balb/cJ embryo development and formation in vitro. |
### Instruction:
Is human trabecular meshwork cell survival dependent on perfusion rate?
### Response:
| A minimum perfusion rate of 1 microliter/minute is required for trabecular cell survival in perfusion organ culture. Constant pressure perfusion of medium is unsuccessful in maintaining trabecular cells in long-term culture if low perfusion rates occur. Constant flow appears to mimic the in vivo situation more closely. |
### Instruction:
Does bronchodilator response at low lung volumes predict bronchiolitis obliterans in lung transplant recipients?
### Response:
| BR appears to be useful as an early marker of BOS. The development of BR in selected patients should lead to closer monitoring and possibly a trial of augmented immunosuppression to arrest the establishment of BOS. |
### Instruction:
Is smooth muscle cell migration and proliferation enhanced in abdominal aortic aneurysms?
### Response:
| From these data it is clear that there are intrinsic differences in cellular kinetics between SMC from the two disease states, supporting the hypothesis that AAA are not the result of atherosclerosis. |
### Instruction:
Are myocardial and cerebral oxygen delivery adversely affected by cocaine administration to early-gestation fetal sheep?
### Response:
| Cerebral and myocardial oxygen delivery are unimpeded by maternal cocaine administration in 0.7 term gestation ovine fetuses. |
### Instruction:
Is detection of circulating tumor cells in colorectal cancer by immunobead-PCR a sensitive prognostic marker for relapse of disease?
### Response:
| This study indicates that detection of circulating tumor cells perioperatively by immunobead-PCR provides a sensitive prognostic marker for recurrent and metastatic colorectal cancer. |
### Instruction:
Is combined overexpression of urokinase , urokinase receptor , and plasminogen activator inhibitor-1 associated with breast cancer progression : an immunohistochemical comparison of normal , benign , and malignant breast tissues?
### Response:
| We showed that overexpression of uPAR, uPA, and its main inhibitor, PAI-1, is a constant feature of invasive ductal breast carcinomas. However, the expression of the above fibrinolytic reactants is not specific for breast cancer since positive staining for these molecules was frequently observed in benign breast lesions as well as in normal breast tissues. The combined increased expression of uPA and its cellular receptor, uPAR on the surface of tumor epithelial cells may account for the activation of the proteolytic system which occurs in breast cancer. |
### Instruction:
Does the potent angioinhibin AGM-1470 stimulate normal but not human tumoral lymphocytes?
### Response:
| Our results demonstrate that AGM-1470 is ineffective on lymphoid tumor cell proliferation and could potentially be safely administered to lymphoma patients. |
### Instruction:
Does increased blood hemoglobin attenuate splanchnic vasodilation in portal-hypertensive rats by nitric oxide inactivation?
### Response:
| Gastrointestinal vasodilation associated with portal hypertension can be attenuated by increasing blood hemoglobin concentration. Inactivation of overproduced NO by hemoglobin may account for this effect. |
### Instruction:
Is loss of heterozygosity of the RB gene a poor prognostic factor in patients with osteosarcoma?
### Response:
| RB gene LOH appears to be an early predictive feature for osteosarcomas that indicates a potential unfavorable outcome. RB LOH study might shortly help to identify high-risk patients earlier. If this is verified, therapy could then be adapted earlier to the individual's real risk of relapse. |
### Instruction:
Is low-molecular-weight heparinoid orgaran more effective than aspirin in the prevention of venous thromboembolism after surgery for hip fracture?
### Response:
| This study demonstrates that Orgaran is significantly more efficacious than aspirin in preventing postoperative venous thromboembolism in patients undergoing surgery for fractured hips, with no evidence of any increase in hemorrhagic complications. |
### Instruction:
Is persistent elevation of plasma insulin levels associated with increased cardiovascular risk in children and young adults . The Bogalusa Heart Study?
### Response:
| Elevated insulin levels persist from childhood through young adulthood, resulting in a clinically relevant adverse cardiovascular risk profile in young adults. |
### Instruction:
Are [ Regular vitamin A supplements safe for pregnant women who consume few liver products ]?
### Response:
| Regular vitamin A supplements may be safely used by pregnant women who consume little or no liver or liver products. |
### Instruction:
Are chromosomal abnormalities involving 11q13 associated with poor prognosis in patients with squamous cell carcinoma of the head and neck?
### Response:
| The results suggest that in SCCHN the presence of a complex karyotype is associated with poor prognosis, particularly when 11q13 rearrangements are present. |
### Instruction:
Is existential well-being an important determinant of quality of life . Evidence from the McGill Quality of Life Questionnaire?
### Response:
| The hypothesis that the existential domain is important, especially to those patients with a life-threatening illness, is supported because multiple regression showed that the existential subscale is at least as important as any other subscale in predicting a single item scale measuring the overall quality of life and plays a greater role in determining the quality of life of patients with local or metastatic disease than in patients with no evidence of disease. |
### Instruction:
Does mononuclear cell line THP-1 internalize bactericidal/permeability-increasing protein by a non-receptor-mediated mechanism consistent with pinocytosis?
### Response:
| Bactericidal/permeability-increasing protein is rapidly internalized by mononuclear cells in a nonspecific fashion not saturable at very high doses, which is consistent with pinocytosis. This process may represent a disposal mechanism for lipopolysaccharide in closed-space infections and may be partially responsible for the rapid clearance of BPI from the peripheral circulation. |
### Instruction:
Does liver damage in the rat induce hepatocyte stem cells from biliary epithelial cells?
### Response:
| Biliary epithelium is an effective and substantiative hepatocyte progenitor compartment under appropriate conditions. |
### Instruction:
Does gastrin receptor antagonist CI-988 inhibit growth of human colon cancer in vivo and in vitro?
### Response:
| This was the first study in cancer with this potent gastrin receptor antagonist, CI-988. The results suggest that CI-988 may be of use in inhibiting the growth of colorectal cancer. |
### Instruction:
Does intravesical electrical stimulation induce a prolonged decrease in micturition threshold volume in the rat?
### Response:
| Intravesical electrical stimulation induced a prolonged modulation of the micturition reflex in anesthetized rats. The effect was due to activation of bladder mechanoreceptor afferents and remained long after the period of stimulation. It is proposed that the modulation was due to a prolonged enhancement of excitatory synaptic transmission in the central micturition reflex pathway. Such a modulation may underlie the curative effect of IVES in certain voiding disorders. |
### Instruction:
Does nonischemic Postoperative Seizure Increase Mortality After Cardiac Surgery?
### Response:
| When PS is associated with acute cerebrovascular accident, a significant increase in postoperative morbidity and mortality can be expected. However, in those with isolated PS (without evidence of new neurologic injury), perioperative mortality and morbidity are comparable to those without any neurologic complications. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.