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### Instruction:
Does mMP13 regulate Aggressiveness of Pediatric Multiple Myeloma Through VEGF-C?
### Response:
| Since VEGF-C is a well-known growth factor for lymphatic vessels, our data suggest that MMP13 may activate VEGF-C to promote cancer cell metastasis through lymphatic vascular systems in pediatric MM. |
### Instruction:
Do soluble Notch ligand and receptor peptides act antagonistically during angiogenesis?
### Response:
| The minimal binding domains of Notch ligands are sufficient to interfere with Notch signalling. The corresponding soluble Notch1 EGF11-13 peptide binds stronger to inhibitory Notch ligands and thereby promotes Notch signalling in endothelial cells. |
### Instruction:
Does 5-Aminolevulinic acid-mediated sonodynamic therapy induce anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis?
### Response:
| ALA-SDT showed synergistic anti-tumor effects in malignant melanoma by constituting a positive feedback loop of p53-miR-34a-Sirt1 axis. |
### Instruction:
Is methamphetamine injecting associated with phylogenetic clustering of hepatitis C virus infection among street-involved youth in Vancouver , Canada?
### Response:
| In this study of street-involved youth with HCV infection and recent injecting, 14% demonstrated phylogenetic clustering. Phylogenetic clustering was associated with recent methamphetamine injection, suggesting that methamphetamine drug injection may play an important role in networks of HCV transmission. |
### Instruction:
Do refractory celiac disease and EATL patients show severe malnutrition and malabsorption at diagnosis?
### Response:
| The nutritional status of patients with RCDII and EATL is inferior compared with untreated naïve CD patients at presentation. Both malabsorption as well as hypermetabolism contribute to malnutrition. |
### Instruction:
Does ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identify a mutation-based prognostic gene signature?
### Response:
| Genetic variants identified by NGS technology in FFPE samples are clinically useful to predict prognosis in advanced OSCC patients. |
### Instruction:
Does tRPV4 mediate flow-induced increases in intracellular Ca in medullary thick ascending limbs?
### Response:
| We conclude that flow-induced increases in Cai are mediated primarily by TRPV4 in the rat mTAL. |
### Instruction:
Does temporary dietary iron restriction affect the process of thrombus resolution in a rat model of deep vein thrombosis?
### Response:
| These results suggest that dietary iron restriction affects the process of thrombus resolution in DVT. |
### Instruction:
Is healthcare workers ' decision-making about transmission-based infection control precautions improved by a guidance summary card?
### Response:
| There is a lack of knowledge about TBP among HCWs. This study demonstrates how an inexpensive TBP summary card is an effective mechanism for improving (i) point-of-care access to TBP guidance and (ii) decision-making about appropriate implementation of TBP. |
### Instruction:
Does overexpression of pyruvate dehydrogenase kinase support dichloroacetate as a candidate for cutaneous melanoma therapy?
### Response:
| Our results suggest that PDK expression may play a role in melanoma development and that DCA can be useful for CM therapy, alone or in combination with mTOR inhibitors. |
### Instruction:
Are diagnostic delays common among patients with hepatocellular carcinoma?
### Response:
| Nearly 20% of patients with HCC wait more than 3 months from presentation to diagnosis, which can contribute to interval tumor growth. |
### Instruction:
Is ethanol Modulation Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors?
### Response:
| Our results are consistent with a TM mechanism of EtOH modulation in Cys-loop receptors. This work highlights the relevance of bacterial homologs as valuable model systems for studying ion channel function of human receptors and demonstrates the modularity of these channels across species. |
### Instruction:
Does miR-138 suppress Cell Proliferation by Targeting Bag-1 in Gallbladder Carcinoma?
### Response:
| Expression of miR-138 is frequently reduced in gallbladder carcinoma when compared to normal cells. Overexpression of miR-138 inhibited cell proliferation by directly suppressing the expression of Bag-1. These results suggest that miR-138 plays an important role in inhibiting the growth of gallbladder carcinoma. |
### Instruction:
Does excessive iodine intake increase the recurrence rate of graves ' disease after withdrawal of the antithyroid drug in an iodine-replete area?
### Response:
| The present study suggests that excessive iodine intake does not have an effect on the clinical outcomes of Graves' disease in an iodine-replete area, and therefore diet control with iodine restriction might not be necessary in the management of Graves' disease. |
### Instruction:
Do validation of the Community Integration Questionnaire in the adult burn injury population?
### Response:
| The CIQ-13 demonstrates validity and reliability in the adult burn survivor population addressing issues of self/family care and social integration. This instrument is useful in future research of community reintegration outcomes in the burn population. |
### Instruction:
Is elevated serum monocyte chemoattractant protein-1 levels and its genetic polymorphism associated with diabetic retinopathy in Chinese patients with Type 2 diabetes?
### Response:
| The results suggested that the -2518 GG genotype and G allele of MCP-1 are associated with an increased risk of PDR in the Chinese Han population. This polymorphism may influence the expression of the MCP-1 gene, which may play an important role in the pathogenesis of DR. |
### Instruction:
Does serum Angiopoietin-like Protein 2 improve Preoperative Detection of Lymph Node Metastasis in Colorectal Cancer?
### Response:
| Serum ANGPTL2 improves preoperative detection of LN metastasis in CRC. |
### Instruction:
Does absolute lymphocyte count with extreme hyperleukocytosis have a prognostic impact in chronic lymphocytic leukemia?
### Response:
| Although our results do not confirm that high initial levels of WBC are independently associated with shorter survival in CLL, the clinical course in these cases appears to be aggressive and conventional prognostic factors are not valid in this patient sub-group. |
### Instruction:
Does [ Analysis on 2011 quality control result on aerobic plate count of microbiology laboratories in China ]?
### Response:
| The quality control program has provided scientific data that the aerobic plate count capability of the laboratories meets the requirements of monitoring tasks. |
### Instruction:
Does lenalidomide enhance Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma?
### Response:
| Our data therefore demonstrate that checkpoint signaling plays an important role in providing the tumor-promoting, immune-suppressive microenvironment in multiple myeloma, and that PD-1/PD-L1 blockade induces anti-multiple myeloma immune response that can be enhanced by lenalidomide, providing the framework for clinical evaluation of combination therapy. |
### Instruction:
Is stomatin-like protein 2 expression associated with clinical survival in patients with cervical cancer?
### Response:
| Our study showed STOML2 was correlated to progression in cervical cancer, and implicated it as a potential predictive factor for the prognosis of cervical cancer. |
### Instruction:
Is a wide QRS/T angle in bundle branch blocks associated with increased risk for coronary heart disease and all-cause mortality in the Atherosclerosis Risk in Communities ( ARIC ) Study?
### Response:
| A wide spatial QRS/T angle in BBB is associated with increased risk for CHD and all-cause mortality over and above the predictive value for BBB alone. The risk for women is as high as or higher than that in men. |
### Instruction:
Does experimental acute lung injury induce multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction?
### Response:
| Our results demonstrate that decreases in transcription-permissive, but not increases in transcription-repressive, histone modifications at Angpt1, Tek, and Kdr are a systemic, rather than a lung-restricted, response, involving key end-organs in experimental ALI-sepsis. Given that ventilator-associated pneumonia is a major cause of sepsis in critically ill patients, elucidation of mechanisms mediating epigenetic alterations during sepsis provides fundamental new insights into the pathogenesis of sepsis-induced microvascular leak and subsequent end-organ injury/dysfunction. |
### Instruction:
Does niclosamide suppress cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition?
### Response:
| This study demonstrated the IL6-Stat3-AR axis in prostate cancer is one of the crucial mechanisms of enzalutamide resistance. Niclosamide has the potential to target the IL6-Stat3-AR pathway to overcome enzalutamide resistance and inhibit migration and invasion in advanced prostate cancer. |
### Instruction:
Are low vitamin D levels associated with the presence of serum cryoglobulins in patients with chronic HCV infection?
### Response:
| Severe deficiency of vitamin D was independently associated with mixed cryoglobulinemia in patients with HCV infection. |
### Instruction:
Does treadmill running improve hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography?
### Response:
| Diabetes impaired acetylcholine-induced vasodilator function locally in the arteries <100 μm diameter and decreased hindlimb vascular conductance responded to acetylcholine, while regular treadmill running significantly ameliorated the impaired vasodilator function, and enhanced the decreased conductance in the diabetic mice. |
### Instruction:
Does biliopancreatic diversion with duodenal switch modify plasma chemerin in early and late post-operative periods?
### Response:
| Chemerin has a novel role in surgical injury but not hyperglycemia resolution early after BPD-DS. Over the long term, plasma chemerin declines to a new set point that is partially determined by body fat reductions. |
### Instruction:
Does peripheral blood stem cell transplantation improve liver functional reserve?
### Response:
| Autologous peripheral blood stem cell transplantation can improve several markers of liver health and liver functional reserve and is a promising prospect for clinical application. |
### Instruction:
Does the diagnostic value of cerebrospinal fluid chemistry result in childhood tuberculous meningitis?
### Response:
| Absolute CSF glucose values of <2.2 mmol/L and protein values of >1 g/L differentiated between TBM and non-bacterial meningitis with good specificity, although sensitivity was poor. A CSF to serum glucose ratio is more informative than the absolute value. |
### Instruction:
Is adjuvant Chemotherapy and Radiation Therapy Associated with Improved Survival for Patients with Extrahepatic Cholangiocarcinoma?
### Response:
| This national analysis suggests that ACR are associated with improved survival for high-risk EHC patients, such as those with positive lymph nodes. Until randomized clinical trials are conducted, these may be the best available data to guide adjuvant therapy for resected EHC. |
### Instruction:
Does triptolide improve systolic function and myocardial energy metabolism of diabetic cardiomyopathy in streptozotocin-induced diabetic rats?
### Response:
| (31)P NMR spectroscopy enables assessment of cardiac energy metabolism in whole heart preparations. It detects energy metabolic abnormalities in DCM hearts. Triptolide therapy improves cardiac function and increases cardiac energy metabolism at least partly through upregulation of MAPK signaling transduction. |
### Instruction:
Do [ Allergic factors affect on severity of chronic rhinosinusitis and postoperative outcomes ]?
### Response:
| Allergic factor didn't impact much the severity of chronic rhinosinusitis patients who were failed in expectant treatment, besidesthe postoperative outcomes showed that only influence the severity of nasal discharge, facial pressure and loss of smell. Different kinds of allergen were found between the patients of chronic rhinosinusitis with or without polyps. No significantly functional endoscopic sinusitis sugrery outcome were related to the allergic factor. But the allergic factor may interfere the remission of nasal discharge after surgery. |
### Instruction:
Does magnetic resonance imaging reveal altered distribution of hepatic fat in children with type 1 diabetes compared to controls?
### Response:
| In children with type 1 diabetes, NAFLD may be less common than recent studies have suggested. Children with type 1 diabetes may have a lower fat fraction and a different fat distribution in the liver than controls. Diabetes treatment with MDI or CSII may affect liver fat, but this needs to be confirmed in a larger sample of patients. The heterogeneity of hepatic fat infiltration may affect results when liver biopsy is used for diagnosing fatty liver. |
### Instruction:
Do cLINICAL CHARACTERISTICS AND TREATMENT OUTCOMES OF COATS DISEASE IN A SAUDI ARABIAN POPULATION?
### Response:
| Although rare, Coats disease is usually advanced at presentation and has a poor visual prognosis in the Saudi population, like in other populations. The findings of this study give validity and applicability to the Shields staging scheme, which we recommend using in clinical practice. |
### Instruction:
Does negative Epistasis between Sickle and Foetal Haemoglobin suggest a Reduction in Protection against Malaria?
### Response:
| Higher prevalence of malaria in HbAA compared to HbAS and HbSS confirmed the protective effect of HbS. Lower prevalence of malaria in HbAA with high HbF supports a protective effect of HbF. However, in HbSS, the higher prevalence of malaria with high levels of HbF suggests loss of malaria protection. This is the first epidemiological study to suggest a negative epistasis between HbF and HbS on malaria. |
### Instruction:
Does transplantation of human amnion mesenchymal cells attenuate the disease development in rats with collagen-induced arthritis?
### Response:
| In conclusion, our results indicated that hAMCs could attenuate the disease development in rats with CIA, which might be a promising cell source for therapy of rheumatoid arthritis. |
### Instruction:
Does urolithin A cause p21 up-regulation in prostate cancer cells?
### Response:
| Our results indicate a potential role of UA as a chemopreventive agent for prostate cancer. |
### Instruction:
Does prolyl hydroxylase inhibition correct functional iron deficiency and inflammation-induced anaemia in rats?
### Response:
| PHD inhibition has a beneficial effect on iron metabolism in addition to stimulating the release of EPO. Small-molecule inhibitors of PHD such as JNJ-42905343 represent a mechanism distinct from rhEPO to treat anaemia and FID. |
### Instruction:
Do a novel population balance model for the dilute acid hydrolysis of hemicellulose?
### Response:
| The interpretation of kinetic parameters obtained by fitting a model to only a single set of data may be ambiguous. Although these parameters may correctly reproduce the data, they may not be indicative of the actual rate parameters, unless some care has been taken to ensure that the model describes the true mechanisms of acid hydrolysis. It is possible to challenge the robustness of the model by expanding the experimental data set and hence limiting the parameter space for the fitting parameters. The novel combination of "hard-to-hydrolyse" and population balance dynamics in the model presented here appears to stand up to such rigorous fitting constraints. |
### Instruction:
Are patients with psoriasis at a higher risk of developing nonalcoholic fatty liver disease?
### Response:
| Our findings warrant a detailed assessment of metabolic comorbidities including NAFLD in patients with a primary diagnosis of psoriasis. Lifestyle modifications, including weight loss and smoking cessation, may be necessary for patients with psoriasis to decrease the risk and severity of NAFLD. |
### Instruction:
Is household Food Insecurity Associated with Respiratory Infections Among 6-11-Month Old Infants in Rural Ghana?
### Response:
| Infants living in food insecure households are at an increased risk of respiratory tract morbidity. Interventions that address HHFI might be important to improve infant health in rural Ghana. |
### Instruction:
Is glycA , a biomarker of inflammatory glycoproteins , more closely related to the leptin/adiponectin ratio than to glucose tolerance status?
### Response:
| High plasma GlycA reflects a pro-inflammatory state. Adipose tissue-associated inflammatory processes could contribute to increased circulating levels of glycosylated acute-phase proteins. |
### Instruction:
Does activating PPARα prevent post-ischemic contractile dysfunction in hypertrophied neonatal hearts?
### Response:
| Stimulating fatty acid β-oxidation in neonatal hearts may present a novel cardioprotective intervention to limit post-ischemic contractile dysfunction. |
### Instruction:
Does lenalidomide reduce microglial activation and behavioral deficits in a transgenic model of Parkinson 's disease?
### Response:
| These results support the therapeutic potential of lenalidomide for reducing maladaptive neuroinflammation in PD and related neuropathologies. |
### Instruction:
Does ginsenoside rh2 inhibit cancer stem-like cells in skin squamous cell carcinoma?
### Response:
| Taken together, our data suggest that GRh2 inhibited SCC growth, possibly through reduced the number of Lgr5-positive CSCs. This may be conducted through an interaction between autophagy and β-catenin signaling. |
### Instruction:
Do type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium?
### Response:
| In Chrm3 mice, mucin production is attenuated and is associated with prolonged adherence of C. rodentium to colonic mucosa. The immune response, as characterized by production of TH1/TH17 cytokines, in C. rodentium-infected Chrm3 mice is intact. In addition, M3R activity promotes the development of classically activated macrophages. Our data establish a role for M3R in host defense against C. rodentium through effects on goblet cell mucus production and in the modulation of macrophage phenotype and function. |
### Instruction:
Do low Serum Levels of MicroRNA-19 Are Associated with a Stricturing Crohn 's Disease Phenotype?
### Response:
| These data identify miR-19-3p as a potential circulating marker of stricturing CD. Our data show that microRNAs have utility as noninvasive biomarkers of stricturing CD. Further longitudinal studies are required to determine the prognostic value of miR-19-3p at diagnosis. |
### Instruction:
Is nomegestrol acetate an anti-aromatase agent in human MCF-7aro breast cancer cells?
### Response:
| The MCF-7aro cell line shows high aromatase activity and NOMAC can act as an anti-aromatase agent by inhibiting this activity. This is an important new effect of this progestogen. Because NOMAC can also inhibit sulfatase activity in breast cancer cells, we suggest that this dual effect of NOMAC has attractive possibilities for clinical trials. |
### Instruction:
Does smad3 Signaling promote Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice?
### Response:
| Smad3 mediates diabetic cardiac hypertrophy, fibrosis, and diastolic dysfunction, while preserving normal cardiac geometry and maintaining the integrity of the vascular wall. |
### Instruction:
Do elevations of serum CA-125 predict severity of acute appendicitis in males?
### Response:
| CA-125 levels correlate with the severity of appendicitis in males and may serve as a surrogate marker for the severity of other intra-abdominal surgical diseases. |
### Instruction:
Is activity of the porcine gonadotropin-releasing hormone receptor gene promoter partially conferred by a distal gonadotrope specific element ( GSE ) within an upstream enhancing region , two proximal GSEs and a retinoid X receptor binding site?
### Response:
| Porcine GnRHR promoter activity in alphaT3-1 cells is partially conferred by a distal GSE, two proximal GSEs and a RXR binding site. Basal gonadotrope expression of the porcine GnRHR gene uniquely involves three GSEs and RXR is newly identified as a regulator of GnRHR promoter activity. |
### Instruction:
Does development of a process to disclose amyloid imaging result to cognitively normal older adult research participants?
### Response:
| We developed a document for use with potential study participants to describe the process of amyloid imaging and the implications of amyloid imaging results; and a disclosure process with attention to ongoing monitoring of both mood and safety to receive this information. This document and process will be used in the A4 Study and can be adapted for other research settings. |
### Instruction:
Are terminal 18q deletions stabilized by neotelomeres?
### Response:
| We found that all six deleted chromosomes sequenced were probably stabilized by the healing mechanism leading to a neotelomere formation. |
### Instruction:
Does the efficacy of a lysine-based dendritic hydrogel differ from those of commercially available tissue sealants and adhesives : an ex vivo study?
### Response:
| The efficacy of the PEG-LysNH2 was significantly superior to conventional injury repair methods (sutures) and did not differ from those of commercially available products when sealing small incisions. |
### Instruction:
Are pathogenic pathways activated in each major cell type of the glomerulus in the Cd2ap mutant mouse model of focal segmental glomerulosclerosis?
### Response:
| This study provides a comprehensive analysis of the changing properties of the three cell types of the glomerulus in Cd2ap mutants, identifying activated and repressed pathways and responsible genes, thereby delivering a deeper molecular understanding of this genetic disease. |
### Instruction:
Does olfactory function combined with morphology distinguish Parkinson 's disease?
### Response:
| Although preliminary, these data obtained from a combined morphological and functional evaluation of OB or cardiovascular dysautonomia could be useful for further differential of PD and other PD-related disorders. |
### Instruction:
Does ventilation in situ after cardiac death improve pulmonary grafts exposed to 2 hours of warm ischemia?
### Response:
| The increase in tolerable warm ischemic time in combination with avoiding heparinization and cooling might facilitate the use of DCD lungs for transplantation. |
### Instruction:
Are aging-related renal injury and inflammation associated with downregulation of Klotho and induction of RIG-I/NF-κB signaling pathway in senescence-accelerated mice?
### Response:
| The present results suggest that aging-related inflammation and the development of early-stage CKD are likely associated with the downregulation of Klotho and induction of the RIG-I/NF-κB signaling pathway in 12-month-old SAMP8 mice. Moreover, aged SAMP8 mice with cognitive deficits and renal damage may be a potential mouse model for investigating the kidney-brain axis in the aging process. |
### Instruction:
Is broad spectrum psychiatric comorbidity associated with better executive functioning in an inpatient sample of individuals with schizophrenia?
### Response:
| A broad spectrum approach to psychiatric comorbidity can help to account for differences in the executive functioning of individuals with schizophrenia. In clinical settings, individuals with schizophrenia and psychiatric comorbidity may benefit from intervention strategies that capitalize on their relatively higher executive functioning. |
### Instruction:
Does dimethyl Fumarate protect Brain From Damage Produced by Intracerebral Hemorrhage by Mechanism Involving Nrf2?
### Response:
| A clinically relevant dose of DMF demonstrates potent therapeutic efficacy and impressive 24 h therapeutic window of opportunity. This study merits further evaluation of this compound as potential treatment for ICH in humans. |
### Instruction:
Is the female protective effect in autism spectrum disorder mediated by a single genetic locus?
### Response:
| The results do not support the hypothesis that the FPE is mediated by a single genetic locus; however, this does not exclude the possibility of multiple genetic loci playing a role in the FPE. |
### Instruction:
Do key patterning genes contribute to leg elongation in water striders?
### Response:
| Together, our results suggest that key patterning genes contribute to the dramatic elongation of thoracic appendages in water striders. |
### Instruction:
Do phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer?
### Response:
| sPLA2GIII expression may be used as a risk factor for lymph node metastasis and a prognostic marker in colorectal cancer. In addition, sPLA2GIII and sPLA2GX may play opposing roles in colorectal carcinogenesis. |
### Instruction:
Do post-radiotherapy prostate biopsies reveal heightened apex positivity relative to other prostate regions sampled?
### Response:
| In our experience, persistence of prostate tumor cells after RT increases going from the base to apex. MRI was used in planning and image guidance was performed daily during treatment, so geographic miss of the apex is unlikely. Nonetheless, the pattern observed suggests that attention to apex dosimetry is a priority. |
### Instruction:
Does osteopontin regulate VEGFA and ICAM-1 mRNA Expression in Breast Carcinoma?
### Response:
| Our results support that osteopontin regulates ICAM-1 and VEGFA expression mainly in triple-negative/basal-like breast carcinomas, suggesting a relevant role in the pathogenesis and tumor progression of this molecular subtype. Moreover, VEGFA mRNA levels showed an independent prognostic value in patients with breast cancer. |
### Instruction:
Does negative arousal increase the effects of stimulus salience in older adults?
### Response:
| The effects of negative arousal on subsequent attention were similar in older adults as in younger adults. Moreover, the results support arousal-biased competition theory (Mather & Sutherland, 2011, Perspectives on Psychological Science, 6, 114-133), which predicts that emotional arousal amplifies the effects of stimulus salience in attention and memory. |
### Instruction:
Does aggressive Therapy reduce Disease Activity without Skeletal Damage Progression in Chronic Nonbacterial Osteomyelitis?
### Response:
| An aggressive treatment regimen in CNO improved clinical and imaging measures of disease activity without progression of skeletal damage. |
### Instruction:
Do α-Defensins partially protect human neutrophils against Panton-Valentine leukocidin produced by Staphylococcus aureus?
### Response:
| Panton-Valentine leukocidin (PVL) is a pore-forming toxin produced by Staphylococcus aureus, responsible for neutrophil damage and key player of severe staphylococcal diseases. Antimicrobial peptides produced by neutrophils (HNP1-3) neutralize several other bacterial cytotoxins. We examined the impact of human neutrophil peptides (HNPs) on PVL cytotoxicity against human neutrophils and we found that HNPs bind to both LukS and LukF components of PVL, thereby inhibiting pore formation and neutrophil lysis. Our results suggest that HNP3 may impair PVL conformational changes required to form a functional pore and provide insight into the pathogenesis of PVL-related staphylococcal infection, with potential impact on the disease outcome. |
### Instruction:
Does characterization of 1577 primary prostate cancers reveal novel biological and clinicopathologic insights into molecular subtypes?
### Response:
| The m-ERG classifier showed 95% accuracy in an independent validation subset (155 samples). Across cohorts, 45% of PCas were classified as m-ERG(+), 9% as m-ETS(+), 8% as m-SPINK1(+), and 38% as triple negative (m-ERG(-)/m-ETS(-)/m-SPINK1(-)). Gene expression profiling supports three underlying molecularly defined groups: m-ERG(+), m-ETS(+), and m-SPINK1(+)/triple negative. On multivariate analysis, m-ERG(+) tumors were associated with lower preoperative serum prostate-specific antigen and Gleason scores, but greater extraprostatic extension (p<0.001). m-ETS(+) tumors were associated with seminal vesicle invasion (p=0.01), while m-SPINK1(+)/triple negative tumors had higher Gleason scores and were more frequent in Black/African American patients (p<0.001). Clinical outcomes were not significantly different among subtypes. |
### Instruction:
Does miRNA-150 downregulation promote pertuzumab resistance in ovarian cancer cells via AKT activation?
### Response:
| miRNA-150 downregulation may contribute to the pertuzumab resistance in ovarian cancer via, at least in part, PI3K-akt pathway. |
### Instruction:
Does cDC42-Interacting Protein 4 Gene be Down Trans-Regulated by HBV DNA polymerase Trans Activated Protein 1?
### Response:
| HBVDNAPTP1 may be involved in the positive regulation on the initiation of monocyte apoptosis. The result contribute to reveal the HBVDNAPTP1 biological functions and provide new evidences for further exploration of the regulatory mechanism of HBVDNAPTP1. |
### Instruction:
Do evaluation of cognitive and behavioral effects of peer education model-based intervention to sun safe in children?
### Response:
| Peer education program is somewhat effective in some dimensions for improving children's understanding of sun safe knowledge and behavior. |
### Instruction:
Does short-term Intravenous Antibiotic Treatment in Uncomplicated Diverticulitis Increase the Risk of Recurrence Compared to Long-term Treatment?
### Response:
| Treatment of diverticulitis with a short IV antibiotic treatment is possible and does not modify the recurrence rate in patients with uncomplicated diverticulitis. |
### Instruction:
Does high-throughput transcriptomic analysis nominate proteasomal genes as age-specific biomarkers and therapeutic targets in prostate cancer?
### Response:
| Our data show significant global differences in prognostic genes between older versus younger men. We nominate proteasomeal gene expression as an age-specific biomarker and potential therapeutic target specifically in younger men. Limitations of our study include clinical differences between cohorts, and increased comorbidities and lower survival in older patients. These intriguing findings suggest that current models of PCa biology do not adequately represent genetic heterogeneity of PCa related to age, and future clinical trials would benefit from stratification based on age. |
### Instruction:
Does transcutaneous Vagus Nerve Stimulation modulate Default Mode Network in Major Depressive Disorder?
### Response:
| tVNS can significantly modulate the DMN FC of MDD patients; our results provide insights to elucidate the brain mechanism of tVNS treatment for MDD patients. |
### Instruction:
Does roux-en-Y gastric bypass attenuate the progression of cardiometabolic complications in obese diabetic rats via alteration in gastrointestinal hormones?
### Response:
| RYGB has beneficial cardiometabolic effects through alterations in GI hormones in a severely obese and diabetic rodent model. |
### Instruction:
Does body mass index predict operative time in elective colorectal procedures?
### Response:
| BMI, as an objective measure of obesity, is a direct, statistically significant independent predictor of operative time across elective colorectal procedures. |
### Instruction:
Are dietary Patterns Derived Using Exploratory and Confirmatory Factor Analysis Stable and Generalizable Across Race , Region , and Gender Subgroups in the REGARDS Study?
### Response:
| Five meaningful dietary patterns emerged in the REGARDS study and showed strong congruence across race, sex, and region. Future research will examine associations between these patterns and health outcomes to better understand racial disparities in disease and inform prevention efforts. |
### Instruction:
Is cardiac development in zebrafish and human embryonic stem cells inhibited by exposure to tobacco cigarettes and e-cigarettes?
### Response:
| These data indicate a negative effect of both tobacco cigarettes and e-cigarettes on heart development in vitro and in vivo. Tobacco cigarettes are more toxic than E-cigarettes and exhibit a broader spectrum of cardiac developmental defects. |
### Instruction:
Does clostridium sordellii genome analysis reveal plasmid localized toxin genes encoded within pathogenicity loci?
### Response:
| Genome analysis of C. sordellii reveals that the LCCs, the major virulence factors, are localised on plasmids. Many strains do not contain the LCC genes; it is probable that in several of these cases the plasmid has been lost upon laboratory subculture. Our data are consistent with LCCs being the primary virulence factors in the majority of infections, but LCC-negative strains may precipitate certain categories of infection. A high quality genome sequence reveals putative virulence factors whose role in virulence can be investigated. |
### Instruction:
Does chronic Cigarette Smoking in Healthy Middle-Aged Individuals be Associated With Decreased Regional Brain N-acetylaspartate and Glutamate Levels?
### Response:
| This study provides additional novel evidence that chronic smoking in young and middle-aged individuals is associated with significant age-related neurobiological abnormalities in anterior frontal regions implicated in the development and maintenance of addictive disorders. |
### Instruction:
Do esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms?
### Response:
| The rates of CRN and advanced CRN are significantly increased in ESCC. Colonoscopy should be considered at ESCC diagnosis. |
### Instruction:
Does serum chemokine network correlate with chemotherapy in non-small cell lung cancer?
### Response:
| Our data identify an NSCLC-specific profile of inflammatory mediators that may be useful for cancer sub-classification, as well as the evaluation of therapeutic effects and overall survival. |
### Instruction:
Does prolonged right ventricular ejection delay identify high risk patients and gender differences in Brugada syndrome?
### Response:
| We demonstrated that a previous history of malignant events was associated with longer RVEDs. Our findings supported the RV conduction delay mechanism behind BS and demonstrated for the first time that the predominant malignant male Brugada phenotype might also be the result of a more delayed RV conduction in males. |
### Instruction:
Do human Umbilical Cord Mesenchymal Stem Cells Inhibit the Function of Allogeneic Activated Vγ9Vδ2 T Lymphocytes In Vitro?
### Response:
| These results indicated that UC-MSCs efficiently suppressed the proliferation and cytotoxicity of Vγ9Vδ2 T cells and modulated their cytokine production. Fas-L and TRAIL were involved in the regulation. Cell contact and apoptosis of Vγ9Vδ2 T cells were not necessary for the inhibition. |
### Instruction:
Is lgr5 a potential prognostic marker in patients with cervical carcinoma?
### Response:
| Lgr5 may play an important role in the development and progression of cervical carcinoma, and may be a potential therapeutic target for the treatment of cervical carcinoma. |
### Instruction:
Does exercise capacity independently predict bone mineral density and proximal femoral geometry in patients with acute decompensated heart failure?
### Response:
| In male patients with ADHF, osteoporosis and vertebral fracture are prevalent, and exercise capacity independently predicts bone mass and geometry. Given that heart failure patients with reduced exercise capacity carry a substantial increased risk of fracture, proper osteoporosis evaluation is important in these patients. |
### Instruction:
Does quercetin inhibit HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion?
### Response:
| Our findings suggest that suppression of the HGF/c-Met signaling pathway contributes to the anti-metastatic action of quercetin in melanoma. |
### Instruction:
Are lipoprotein ratios better than conventional lipid parameters in predicting coronary heart disease in Chinese Han people?
### Response:
| Our data indicate that the lipoprotein ratios are superior to conventional lipid parameters as predictors for CHD. Of the ratios, apoB100/apoAI is the best to predict CHD risk. |
### Instruction:
Does transcriptomic analysis of wheat near-isogenic lines identify PM19-A1 and A2 as candidates for a major dormancy QTL?
### Response:
| The efficient identification of these strong candidates demonstrates the utility of our transcriptomic pipeline for rapid QTL to gene mapping. By using this approach we are able to provide a comprehensive genetic analysis of the major source of grain dormancy in wheat. Further analysis across a diverse panel of bread and durum wheats indicates that this important dormancy QTL predates hexaploid wheat. The use of these genes by wheat breeders could assist in the elimination of pre-harvest sprouting in wheat. |
### Instruction:
Does elevated expression of USP9X correlate with poor prognosis in human non-small cell lung cancer?
### Response:
| The current study demonstrated that the expression of USP9X in NSCLC tissue was significantly higher than that in normal lung tissue and that this elevated expression level of USP9X was associated with poor prognosis among NSCLC patients, suggesting that USP9X might serve as a prognostic biomarker for NSCLC. |
### Instruction:
Does prehospital oral chlorhexidine reduce the rate of ventilator-associated pneumonia among critically ill trauma patients : A prospective concurrent-control study?
### Response:
| The prehospital administration of oral chlorhexidine does not reduce the CPIS score over the first 48 hours of admission for intubated trauma patients. Further study should explore other prehospital strategies of reducing complications of critical illness. |
### Instruction:
Does perivascular adipose adiponectin correlate with symptom status of patients undergoing carotid endarterectomy?
### Response:
| Symptomatic and asymptomatic carotid endarterectomy patients display a tissue-specific difference in perivascular adipose adiponectin. This difference, which was not seen in plasma or subcutaneous compartments, supports a potential local paracrine relationship with vascular disease processes that may be related to stroke mechanisms. |
### Instruction:
Are racial minorities more likely than whites to report lack of provider recommendation for colon cancer screening?
### Response:
| Racial minorities are less likely than whites to receive a physician recommendation for CRC screening. Future research should evaluate why race appears to influence provider recommendations to pursue CRC screening; this is an important step to reduce disparities in CRC screening and lessen the burden of CRC in the United States. |
### Instruction:
Does rectosigmoid Localization of Radiopaque Markers Correlate with Prolonged Balloon Expulsion in Chronic Constipation : Results from a Multicenter Cohort?
### Response:
| Among patients with chronic constipation undergoing ROM transit testing, there is no association between rectosigmoid location of markers and rectoanal gradient or prolonged balloon expulsion. |
### Instruction:
Does pNPLA3 Gene Polymorphism be Associated With Predisposition to and Severity of Alcoholic Liver Disease?
### Response:
| PNPLA3 genetic polymorphism (rs738409 C>G) is associated with increased risk for the entire spectrum of ALD among drinkers including ALI, AC, and HCC. Studies are needed to clarify association of PNPLA3 polymorphism and steatosis in alcoholics. PNPLA3 gene may potentially be a therapeutic target in ALD. |
### Instruction:
Does antioxidant metallothionein alleviate endoplasmic reticulum stress-induced myocardial apoptosis and contractile dysfunction?
### Response:
| Taken together, our data favor a beneficial effect of metallothionein against ER stress-induced cardiac dysfunction possibly associated with attenuation of myocardial apoptosis. |
### Instruction:
Are asymptomatic ventricular premature depolarizations necessarily benign?
### Response:
| The absence of typical VPD-related symptoms may be a risk factor for cardiomyopathy and be associated with an adverse outcome. |
### Instruction:
Does human TM9SF4 be a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells?
### Response:
| Altogether, our study reports for the first time the expression of TM9SF4 at the level of normal and leukemic hematopoietic cells and its marked expression at the level of AMLs displaying granulocytic differentiation. |
### Instruction:
Is surname-inferred Andean ancestry associated with child stature and limb lengths at high altitude in Peru , but not at sea level?
### Response:
| Greater Andean ancestry is associated with shorter stature and limb measurements at high but not low altitude. Gene-environment interactions between high altitude and Andean ancestry may exacerbate the trade-off between chest dimensions and stature that was proposed previously, though we could not test this directly. |
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