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### Instruction:
Does tLR9-Targeted STAT3 Silencing abrogate Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients?
### Response:
| Overall, we demonstrate the accumulation of granulocytic MDSCs with prostate cancer progression and the feasibility of using TLR9-targeted STAT3siRNA delivery strategy to alleviate MDSC-mediated immunosuppression. |
### Instruction:
Does vaccination with Melanoma Helper Peptides induce Antibody Responses Associated with Improved Overall Survival?
### Response:
| Vaccination with helper peptides induced both Ab responses and T-cell responses, associated with favorable clinical outcome. Such immune responses may predict favorable clinical outcome to guide combination immunotherapy. Further studies are warranted to understand mechanisms of interaction of these Abs, T-cell responses, and tumor control. |
### Instruction:
Are clinical Operations Variables Associated With Blood Pressure Outcomes?
### Response:
| Findings suggest that clinical operations factors can affect clinical outcomes like BP normalization, and point to the importance of considering outcome effects when organizing clinical care. |
### Instruction:
Does beta-Chemokine CCL15 affect the Adhesion and Migration of Hematopoietic Progenitor Cells?
### Response:
| Our results point to a regulation of HPCs by CCL15 by modulating migratory and adhesive properties of HPCs with the potency to improve HPC short-term engraftment in stem cell transplantation. |
### Instruction:
Does redox signalling to nuclear regulatory proteins by reactive oxygen species contribute to oestrogen-induced growth of breast cancer cells?
### Response:
| Taken together, our results present evidence in the support of E2-induced ROS-mediated AKT signalling leading to the activation of NRF-1-regulated cell cycle genes as well as the impairment of p27 activity, which is presumably necessary for the growth of MCF-7 cells. These observations are important because they provide a new paradigm by which oestrogen may contribute to the growth of breast cancer. |
### Instruction:
Does influence of polyurethane resin die on the fit and adaptation of full veneer crowns?
### Response:
| The fit and adaptation of indirect gold castings made on polyurethane and type IV dental stone dies were comparable. |
### Instruction:
Are preoperative low serum testosterone levels associated with tumor aggressiveness in radical prostatectomy treated cancer patients?
### Response:
| Aggressiveness of the tumor cannot be properly estimated by the GS and pGP found in biopsies. The pGP in prostate specimens is of paramount importance, particularly in the case of a Gleason 7, to appreciate the outcomes and to choose the treatment. Preoperative testosterone should be added to PSA determination to improve prediction of treatment outcomes. |
### Instruction:
Does an 8-O-4 ' norlignan exert oestrogen-like actions in osteoblastic cells via rapid nongenomic ER signaling pathway?
### Response:
| These data show that PPD is a bioactive compound in SWH that exerts oestrogen-like actions in osteoblast-like cells via ligand-independent, estrogen response element (ERE)-independent and mitogen-activated protein (MAP) Kinase-mediated rapid nongenomic ER signaling pathway. |
### Instruction:
Does aqueous extract of Orostachys japonicus A. Berger exert immunostimulatory activity in RAW 264.7 macrophages?
### Response:
| OJ aqueous extract might play a pivotal ethnopharmacologic role as an immunostimulatory agent by promoting Fc gamma receptor (FcγR)-mediated phagocytosis of IgG-opsonized RBCs. On the basis of our results, OJ aqueous extract can enhance innate immunity and may serve as an adjuvant for tumor treatment. |
### Instruction:
Does post t-PA transfer to hub improve outcome of moderate to severe ischemic stroke patients?
### Response:
| Patients with moderate to severe ischemic strokes who were treated with t-PA in a telestroke network may potentially benefit from expert care at a primary stroke center. |
### Instruction:
Is telephone-based low intensity therapy after crisis presentations to the emergency department associated with improved outcomes?
### Response:
| The Australian ED IAPT program demonstrated that the UK IAPT program could be adapted for emergency mental health patients and be associated with similar clinical benefits as the original program. |
### Instruction:
Does short Sleep Duration be Related to Emerging Cardiovascular Risk Factors in Obese Children?
### Response:
| Short sleep duration increases the severity of obesity and is related to cardiovascular risk factors in children. |
### Instruction:
Is reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington 's disease following transplantation of bone-marrow-derived mesenchymal stem cells dependent on passage number?
### Response:
| The results from this study demonstrate that BM MSCs hold significant therapeutic value for HD, and that the amount of time the cells are exposed to in vitro culture conditions can alter their efficacy. |
### Instruction:
Does whole-Slide Imaging of Pap Cellblock Preparations be a Potentially Valid Screening Method?
### Response:
| WSI of CB preparations is a feasible method to achieve high-quality specimen preparations. It is as sensitive as liquid-based methods and appears to be highly specific for the detection of LSIL and HSIL. |
### Instruction:
Is vitamin D deficiency at melanoma diagnosis associated with higher Breslow thickness?
### Response:
| Vitamin D deficiency at the time of melanoma diagnosis is associated with thicker tumours that are likely to have a poorer prognosis. Ensuring vitamin D levels of 50 nmol/L or higher in this population could potentially result in 18% of melanomas having Breslow thickness of <0.75 mm rather than ≥0.75 mm. |
### Instruction:
Does oxygenation decrease elastin secretion from rat ductus arteriosus smooth muscle cells?
### Response:
| Given that elastin forms internal elastic lamina and elastic fibers in the vascular muscle layers, and that a rise in oxygen concentration reduced the secretion of elastin, this suggests that the rise in blood oxygen concentration after birth reduces the secretion of elastin, and therefore may play a role in DA structural remodeling after birth. |
### Instruction:
Does advanced fibrosis associate with atherosclerosis in subjects with nonalcoholic fatty liver disease?
### Response:
| Advanced fibrosis indicated by NFS was positively associated with CIMT, presence of carotid plaque and arterial stiffness in the NAFLD patients, independent of conventional cardiometabolic risk factors and insulin resistance. |
### Instruction:
Are enteric glial cells associated with stress-induced colonic hyper-contraction in maternally separated rats?
### Response:
| Colonic EGCs exhibited structural alterations according to the stress intensity. EGCs were associated with stress-induced colonic hyper-contraction in the combined stress rats, which may underlie the pathogenesis of IBS. |
### Instruction:
Does electroacupuncture inhibit weight gain in diet-induced obese rats by activating hypothalamic LKB1-AMPK signaling?
### Response:
| This study suggests that hypothalamic LKB1-AMPK-ACC signaling plays an important role in EA treatment for obesity. |
### Instruction:
Does oxygen Tension regulate Human Mesenchymal Stem Cell Paracrine Functions?
### Response:
| The present study investigated and characterized select aspects of the human mesenchymal stem cell (hMSC) secretome and assessed its in vitro and in vivo biological bioactivity as a function of oxygen tension, specifically near anoxia (0.1% O2) and hypoxia (5% O2), conditions that reflect the environment to which MSCs are exposed during MSC-based therapies in vivo. The present study provided the first evidence of a shift of the hMSC cytokine signature induced by oxygen tension, particularly near anoxia (0.1% O2). Conditioned media obtained from hMSCs cultured under near anoxia exhibited significantly enhanced chemotactic and proangiogenic properties and a significant decrease in the inflammatory mediator content. These findings provide new evidence that elucidates aspects of great importance for the use of MSCs in regenerative medicine, could contribute to improving the efficacy of such therapies, and most importantly highlighted the interest in using conditioned media in therapeutic modalities. |
### Instruction:
Does β-Glucan from Saccharomyces cerevisiae induce IFN-γ Production In Vivo in BALB/c Mice?
### Response:
| IFN-γ plays an important role in immunity against viral and bacterial infections. Our experiments have shown that β-glucan preparations enhance IFN-γ production in BALB/c mice and can be potentially used for immune system stimulation in mammals. Current results may be used to develop soluble β-glucan nutritional supplements. |
### Instruction:
Does cigarette smoking worsen systemic inflammation in persons with metabolic syndrome?
### Response:
| The study demonstrates an additive effect of cigarette smoking on the risk of systemic inflammation in MetS thus highlighting the need for determining smoking status among those with MetS and aggressively targeting smoking cessation in this population. |
### Instruction:
Are hippocampal volume and depressive symptoms linked to serum IL-18 in schizophrenia?
### Response:
| These findings demonstrate that the levels of circulating bioactive IL-18 are related to both hippocampal volume and severity of psychopathologic symptoms in patients with SCZ, confirming the involvement of the cytokine in SCZ pathophysiology and suggesting hippocampal-dependent and neuroprotective functions of IL-18 in this clinical context. |
### Instruction:
Do αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features?
### Response:
| Our observation that a massively expanded TCR Vβ1-Jβ2.3 chain paired with distinct yet closely related canonical or atypical MAIT cell-related α chains strongly points to an antigen-driven process in early active MS brain lesions. |
### Instruction:
Does the duodenal glucose load impact the oral disposition index in healthy subjects?
### Response:
| The rate of duodenal glucose delivery has a major impact on insulin release and, thereby, DI. This suggests that the rate of gastric emptying, which determines duodenal glucose delivery, is a determinant of DI. |
### Instruction:
Is higher BMI associated with reduced brain volume in heart failure?
### Response:
| Our findings suggest increased BMI negatively affects brain volume in HF, and higher BMI interacts with cerebral perfusion to impact gray matter volume. The mechanisms for these findings remain unclear and likely involve multiple physiological processes. Prospective studies are needed to elucidate the exact pattern and rates of brain changes in obese HF persons. |
### Instruction:
Are radioactive seed implantation and lobaplatin chemotherapy safe and effective in treating patients with advanced lung cancer?
### Response:
| CT-guided 125I seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol are safe and effective in treating patients with advanced lung cancer. |
### Instruction:
Does single-dose local simvastatin injection improve implant fixation via increased angiogenesis and bone formation in an ovariectomized rat model?
### Response:
| A single local injection of simvastatin significantly increased bone formation, promoted osseointegration, and enhanced implant fixation in ovariectomized rats. The underlying mechanism appears to involve enhanced BMP2 expression and angiogenesis in the target bone. |
### Instruction:
Is endolymphatic hydrops prevalent in the first weeks following cochlear implantation?
### Response:
| EH is prevalent in the first weeks after implant surgery, even in the absence of significant electrode insertion trauma. |
### Instruction:
Is nuclear C-MYC expression level associated with disease progression and potentially predictive of two year overall survival in prostate cancer?
### Response:
| Nuclear C-MYC overexpression may be associated with disease progression and potentially predictive of 2-year OS in PCa. This is the first study to demonstrate an association between nuclear C-MYC immunostaining and TMPRSS2-ERG status in PCa. |
### Instruction:
Is advanced glycation end-product expression upregulated in the gastrointestinal tract of type 2 diabetic rats?
### Response:
| The AGE and RAGE expression was up-regulated in the GI tract of GK diabetic rats and may contribute to GI dysfunction in type 2 diabetic patients. |
### Instruction:
Do k ( V ) 7.4 channels participate in the control of rodent renal vascular resting tone?
### Response:
| It is concluded that K(V)7 channels, via nifedipine sensitive channels, have a role in the regulation of basal renal vascular tone. There is no indication that K(V)7 channels have an effect on agonist-induced renal vasoconstriction while there is a small effect on acetylcholine-induced vasodilation. |
### Instruction:
Does abnormal Myocardial Function be Related to Myocardial Steatosis and Diffuse Myocardial Fibrosis in HIV-Infected Adults?
### Response:
| HIV-infected adults have reduced myocardial function as compared to controls in the absence of known CVD. Decreased cardiac function was associated with abnormal myocardial tissue composition characterized by increased lipid levels and diffuse myocardial fibrosis. Metabolic alterations related to antiretroviral therapy and chronic inflammation may be important targets for optimizing long-term cardiovascular health in HIV-infected individuals. |
### Instruction:
Is severe intrahepatic cholestasis of pregnancy a risk factor for preeclampsia in singleton and twin pregnancies?
### Response:
| ICP increases the incidence of PET; severe disease was a major risk factor for preeclampsia. Therefore, we strongly suggest including routine evaluation for preeclampsia in the treatment of women with moderate and severe ICP. |
### Instruction:
Is high-normal urinary albumin-to-creatinine ratio independently associated with metabolic syndrome in Chinese patients with type 2 diabetes mellitus : A cross-sectional community-based study?
### Response:
| These results suggest that UACR even within the normal range is independently associated with MetS in Chinese community-based patients with type 2 diabetes mellitus. |
### Instruction:
Does total atrial conduction time evaluated with tissue Doppler imaging increase in hypertensive patients with hyperuricemia?
### Response:
| TACT increases in patients with hyperuricemia. Certainly, larger studies in different populations should further examine this potential association. |
### Instruction:
Does nOB1 expression predict early response to cisplatin-based chemotherapy in patients with advanced non-small cell lung cancer?
### Response:
| Our results suggest that enhanced expression of NOB1 related with poor early response to cisplatin-based chemotherapy in patients with advanced non-small cell lung cancer. |
### Instruction:
Does estrogen promote the survival of human secretory phase endometrial stromal cells via CXCL12/CXCR4 up-regulation-mediated autophagy inhibition?
### Response:
| CXCL12 down-regulates secretory phase ESC autophagy. |
### Instruction:
Is hemodynamic , not ventilatory , inefficiency associated with high VE/VCO2 slope in repaired , noncyanotic congenital heart disease?
### Response:
| A high VE/VCO₂ slope observed in patients with repaired, noncyanotic CHD seems not to depend on excessive ventilation but on hypoperfusion due to impaired cardiac output response to incremental exercise. This finding should focus researchers' attention mainly on the heart when addressing exercise pathophysiology of this patient population. |
### Instruction:
Does dental caries and their treatment need in 3-5 year old preschool children in a rural district of India?
### Response:
| The most common pattern was pit and fissure, then maxillary anterior pattern, posterior proximal pattern, and posterior buccal lingual smooth surface pattern. The mean deft value was higher in males as compared to females. There is a greater need for oral health education among parents and teachers. |
### Instruction:
Does nicotine Metabolite Ratio be Associated With Lozenge Use But Not Quitting in Smokeless Tobacco Users?
### Response:
| Fast metabolizers may need to self-administer more nicotine replacement in the form of nicotine lozenges to achieve the same clinical response achieved by slower metabolizers using fewer lozenges. |
### Instruction:
Does low anthropometric measures and mortality -- result from the Malmö Diet and Cancer Study?
### Response:
| These results imply that BMI or percent body fat could be used to identify lean individuals at increased mortality risk. |
### Instruction:
Does holoturia arenicola extract modulate bile duct ligation-induced oxidative stress in rat kidney?
### Response:
| The present study revealed that HaE had a profound effect against BDL-induced oxidative stress in the kidney tissues which is the common feature of choestasis in the liver. |
### Instruction:
Does regenerative Therapy prevent Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy?
### Response:
| In narrow QRS HF, a regenerative approach demonstrated functional and structural benefit, introducing the prospect of device-autonomous resynchronization therapy for refractory disease. |
### Instruction:
Does prolonged intra-aortic balloon pump support in biventricular heart failure induce right ventricular reverse remodeling?
### Response:
| Prolonged IABP support of patients presenting with end-stage heart failure and right ventricular dysfunction induced significant improvement in right ventricular and peripheral organ function. |
### Instruction:
Does in situ coating make it easier for children to swallow and tolerate tablets and capsules?
### Response:
| A study of 77 paediatric patients with a median age of nine years, and a range of two to 17 years, found that 86% were able to take the tablets and capsules they had been prescribed after they were coated with the MedCoat. |
### Instruction:
Does remote ischemic preconditioning increase circulating or effector organ concentrations of proopiomelanocortin derivates?
### Response:
| We were not able to demonstrate a detectable increase in circulating POMC derivates by a standard rIPC stimulus, suggesting that rIPC effect is not mediated by local or detectable central release of these derivates. |
### Instruction:
Is age-related decline in mitral peak diastolic velocities unaffected in well-trained runners?
### Response:
| Lifelong endurance running was not found to be associated with major attenuation of the age-related decline in diastolic function at rest or during exercise. |
### Instruction:
Does small heterodimer partner attenuate profibrogenic features of hepatitis C virus-infected cells?
### Response:
| These results demonstrate that overexpression of SHP and activation of AMPK reverses profibrogenic features of HCV-infected cells by decreasing TGF-β and fibrotic gene expression. These findings provide a rationale for SHP as a possible therapeutic target against HCV-induced hepatic fibrosis. |
### Instruction:
Does lung function impairment increase with age of diagnosis in adult onset asthma?
### Response:
| Asthma was diagnosed as frequently in older as in younger adults. Preexisting symptoms were equally common, but lung function was more reduced pre-diagnosis, and declined more rapidly in older adults. This emphasizes the need for a high level of therapeutic attention in patients with asthma diagnosed late in life. |
### Instruction:
Does higher positive lymph node ratio indicate poorer distant metastasis-free survival in adenoid cystic carcinoma patients with nodal involvement?
### Response:
| Positive LN ratio was strongly associated with distant metastasis. Comprehensive treatment should be performed in ACC patients with higher positive LN ratios. In addition, ideal surgical margin should be achieved to acquire better overall survival rate. |
### Instruction:
Does overspeed HIIT in Lower-Body Positive Pressure Treadmill improve Running Performance?
### Response:
| A 4-wk HIIT protocol at 100% vVO2max improves field performance, vVO2max, VO2max and submaximal HR in trained runners. Improvements are similar if intervals are run on a regular treadmill or at higher speeds on a LPBB treadmill with 10% body weight reduction. LBPP could provide an alternative for taxing HIIT sessions. |
### Instruction:
Is family history of autoimmune diseases associated with an increased risk of autism in children : A systematic review and meta-analysis?
### Response:
| An overall increased risk of autism in children with family history of ADs was identified. More mechanistic studies are needed to further explain the association between family history of ADs and increased risk of autism in children. |
### Instruction:
Do cYP3A4∗18B and CYP3A5∗3 polymorphisms contribute to pharmacokinetic variability of cyclosporine among healthy Chinese subjects?
### Response:
| The results indicate that gender and polymorphism in CYP3A4∗18B and CYP3A5∗3 significantly affect cyclosporine pharmacokinetics in healthy subjects. |
### Instruction:
Do human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat?
### Response:
| hMSC therapy decreased E. coli induced pneumonia injury and reduced lung bacterial burden, potentially via enhanced macrophage phagocytosis and increased alveolar LL-37 concentrations. |
### Instruction:
Do pharmacologically relevant doses of valproate upregulate CD20 expression in three diffuse large B-cell lymphoma patients in vivo?
### Response:
| Valproate treatment at pharmacologically relevant doses resulted in upregulation of CD20 in vivo, and also in expected epigenetic modifications. This suggests that pre-treatment with valproate or other HDACis before anti-CD20 therapy could be advantageous in CD20-low B-cell lymphomas. Further studies are warranted to evaluate this conclusion. |
### Instruction:
Does a seven-gene CpG-island methylation panel predict breast cancer progression?
### Response:
| Our findings identify CpG-island methylation profiles with deep impact on clinical outcome, paving the way for use as novel prognostic assays in clinical settings. |
### Instruction:
Is low P-wave amplitude ( < 0.1 mV ) in lead I associated with displaced inter-atrial conduction and clinical recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation?
### Response:
| Low P-wave amplitude (<0.1 mV) in lead I is related to LA remodelling and displaced inter-atrial conduction pattern to low septum, and independently predicts clinical recurrence after RFCA in patients with PAF. |
### Instruction:
Does prophylactic treatment with S100A9 inhibitor paquinimod reduce pathology in experimental collagenase-induced osteoarthritis?
### Response:
| Prophylactic treatment of paquinimod reduces synovial activation, osteophyte formation and cartilage damage in experimental OA with high synovial activation (CIOA) and ameliorates pathological effects of S100A9 in OA synovium ex vivo. |
### Instruction:
Are aTP-binding cassette subfamily B member 1 ( ABCB1 ) and subfamily C member 10 ( ABCC10 ) primary resistance factors for cabazitaxel?
### Response:
| ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel, suggesting that cabazitaxel may have a low affinity for these efflux transporters. |
### Instruction:
Is more Comprehensive Care Among Family Physicians Associated with Lower Costs and Fewer Hospitalizations?
### Response:
| Increasing family physician comprehensiveness of care, especially as measured by claims measures, is associated with decreasing Medicare costs and hospitalizations. Payment and practice policies that enhance primary care comprehensiveness may help "bend the cost curve." |
### Instruction:
Does proteomic analysis of media from lung cancer cells reveal role of 14-3-3 proteins in cachexia?
### Response:
| Our novel findings show that extracellular 14-3-3 proteins may act as previously unidentified myokines and may signal via CD13 to help maintain muscle mass. |
### Instruction:
Do expression of Aurora-B and FOXM1 predict poor survival in patients with nasopharyngeal carcinoma?
### Response:
| Aurora-B and FOXM1 were both adverse prognostic markers for NPC patients treated with chemoradiotherapy. However, the two markers had no significant correlation. |
### Instruction:
Is mean platelet volume a predictor of ST resolution following thrombolysis in acute ST elevation myocardial infarction?
### Response:
| Higher MPV's at admission were associated with lower STR and higher occurrence of major adverse cardiac events in patients receiving thrombolytic therapy for first time STEMI. |
### Instruction:
Is hair cortisone level associated with PTSD׳s dysphoric arousal symptoms in highly traumatized Chinese females?
### Response:
| A sample of females exposed to specific traumatic events was used, and PTSD was assessed using a self-reported measure. |
### Instruction:
Do angiotensin receptor blockers improve survival outcomes after radiofrequency ablation in hepatocarcinoma patients?
### Response:
| Sartans significantly improved overall survival and time to recurrence after radiofrequency ablation in hepatocellular carcinoma patients. |
### Instruction:
Does genome sequencing reveal novel deletions associated with secondary resistance to pyrazinamide in MDR Mycobacterium tuberculosis?
### Response:
| Steadily decreasing sequencing costs are increasing the appeal of WGS as an alternative approach for detecting complex patterns of pyrazinamide resistance in MDR-TB. |
### Instruction:
Does dNA entropy reveal a significant difference in complexity between housekeeping and tissue specific gene promoters?
### Response:
| Functional features comprise DNA sequence patterns that are non-random and hence they have lower entropies. The lower entropy of TS gene promoters can be explained by a higher density of positive and negative regulatory elements, required for genes with complex spatial and temporary expression. |
### Instruction:
Is neoadjuvant chemoradiation for rectal cancer associated with higher rates of thromboembolism?
### Response:
| The prevalence of TE in patients with rectal cancer was 7.8%, with most events occurring in within 30 days of surgery. Neoadjuvant chemoradiation was not associated with an increased risk of TE. |
### Instruction:
Does tPEN prevent rapid pacing-induced calcium overload and nitration stress in HL-1 myocytes?
### Response:
| TPEN prevents Ca(2+) overload and nitration stress in HL-1 atrial myocytes during rapid pacing and circumstances of nitration stress. |
### Instruction:
Is merTK a novel therapeutic target in gastric cancer?
### Response:
| MerTK may be involved in GC carcinogenesis, and it could be a potential novel therapeutic target in GC patients. |
### Instruction:
Is low-density lipoprotein cholesterol of less than 70 mg/dL associated with fewer cardiovascular events in acute coronary syndrome patients : a real-life cohort in Thailand?
### Response:
| ACS patients who received statins and achieved an LDL-C of <70 mg/dL had significantly fewer composite cardiovascular outcomes, confirming "the lower the better" and the benefit of treating to LDL-C target in ACS patient management. |
### Instruction:
Does miR-124 suppress cell motility and adhesion by targeting talin 1 in prostate cancer cells?
### Response:
| Our study demonstrated biological roles and the related mechanism of miR-124 in prostate cancer. The results indicate that talin 1 is very likely a novel player in the anti-metastatic signaling network of miR-124. By down-regulation of talin 1, miR-124 impairs the adhesion, migration, and invasion of prostate cancer cells. |
### Instruction:
Is cognitive impairment a predictor of failure to adhere to anticoagulation of stroke patients with atrial fibrillation?
### Response:
| In stroke and TIA patients with AF, the multifactorial medical and functional constellation rather than cognitive impairment specifically can be an obstacle for long-term OAC. |
### Instruction:
Does roux-en-Y Gastric Bypass Acutely decrease Protein Carbonylation and Increases Expression of Mitochondrial Biogenesis Genes in Subcutaneous Adipose Tissue?
### Response:
| These results suggest that rapid reduction in protein carbonylation and increased mitochondrial biogenesis may explain postoperative metabolic improvements following RYGB. |
### Instruction:
Is waist-to-height ratio more closely associated with alanine aminotransferase levels than body mass index and waist circumference among population-based children : a cross-sectional study in Japan?
### Response:
| The present study showed that WHtR was more closely associated with ALT levels than BMI and WC. Furthermore, only WHtR was significantly positively associated with ALT levels regardless of sex and physique. This study suggests that it is more useful to monitor WHtR than BMI and WC as a surrogate for ALT levels among population-based elementary schoolchildren. |
### Instruction:
Are changes in HRQoL after 12 months of exercise linked to primary care associated with fitness effects in older adults?
### Response:
| PF is positively related with HRQoL. PA significantly improved PF, especially the PF components more impaired at baseline. |
### Instruction:
Is preeclampsia Characterized by Fetal NK Cell Activation and a Reduction in Regulatory T Cells?
### Response:
| These observations indicate that there are significant fetal immune system derangements during preeclampsia. |
### Instruction:
Does β1-Adrenergic Inhibition improve Cardiac and Vascular Function in Experimental Septic Shock?
### Response:
| Adjunction of selective β1-blockade to standard septic shock management enhances intrinsic cardiac contractility and vascular responsiveness to catecholamines. These protective cardiovascular effects are likely predominantly attributed to the anti-inflammatory effect of esmolol. |
### Instruction:
Does streptozotocin-induced diabetes disrupt the body temperature daily rhythm in rats?
### Response:
| Taken together, our findings show the disruption of the body temperature daily rhythm, a new consequence of insulin-dependent diabetes, as well as the beneficial effect of the complementary action of melatonin and insulin restoring the normal rhythmicity. |
### Instruction:
Is serum human trefoil factor 3 a biomarker for mucosal healing in ulcerative colitis patients with minimal disease activity?
### Response:
| Serum TFF3 can potentially be used as a biomarker to assess mucosal healing in UC patients. |
### Instruction:
Does mitochondria-targeted hydrogen sulfide donor AP39 improve neurological outcomes after cardiac arrest in mice?
### Response:
| The current results suggest that administration of mitochondria-targeted sulfide donor AP39 at the time of CPR or after ROSC improves the neurological function and long term survival rates after CA/CPR by maintaining mitochondrial integrity and reducing oxidative stress. |
### Instruction:
Is thyroid function associated with non-alcoholic fatty liver disease in chronic hepatitis B-infected subjects?
### Response:
| Thyroid dysfunction is not common in CHB-infected patients, and the prevalence of hypothyroidism in CHB individuals with or without NAFLD is similar. However, increased serum TSH concentration at the normal range is a significant predictor of hepatic steatosis in patients with CHB. |
### Instruction:
Does long noncoding RNA DANCR increase stemness features of hepatocellular carcinoma by derepression of CTNNB1?
### Response:
| These studies reveal a significance and mechanism of DANCR action in increasing stemness features and offer a potential prognostic marker and a therapeutic target for HCC. |
### Instruction:
Are coronary calcium scores systematically underestimated at a large chest size : A multivendor phantom study?
### Response:
| This multivendor phantom study showed that CCS can be underestimated up to 50% (49%-66%) for Agatston scores and 49% (36%-59%) for mass scores at a larger chest size, which may be relevant for women and large patients. However, CCS underestimation by chest size differs considerably by vendor. |
### Instruction:
Is sensitivity of apoptosis-resistant colon cancer cells to tanshinones mediated by autophagic cell death and p53-independent cytotoxicity?
### Response:
| The current findings strongly indicate that both CTS and DTS could inhibit the growth of apoptosis-resistant colon cancer cells through induction of autophagic cell death and p53-independent cytotoxicity. They are promising candidates to be further developed as therapeutic agents in the adjuvant therapy for colon cancer, especially for the apoptosis-resistant cancer types. |
### Instruction:
Is metabolic profile in early pregnancy associated with offspring adiposity at 4 years of age : the Rhea pregnancy cohort Crete , Greece?
### Response:
| Metabolic dysregulation in early pregnancy may increase the risk of obesity at preschool age. |
### Instruction:
Is type 1 diabetes associated with an increased prevalence of hepatic steatosis?
### Response:
| Our data showed that Type 1 diabetes was not associated with an increased prevalence of steatosis. Moreover, our study provided no specific arguments concerning a link between liver fat content and diabetic complications in patients with Type 1 diabetes. |
### Instruction:
Does brain-Derived Neurotrophic Factor contribute to Colonic Hypermotility in a Chronic Stress Rat Model?
### Response:
| The colonic hypermotility induced by repeated WAS may be associated with the increased expression of endogenous BDNF and TrkB. BDNF may have potential clinical therapeutic use in modulating gut motility. |
### Instruction:
Does vitamin-D Deficiency be Associated with Gallbladder Stasis Among Pregnant Women?
### Response:
| Vitamin D deficiency is highly prevalent among pregnant Indian women. It is associated with GB stasis and lower GBEF. The risk factors for VDD were reduced sun exposure, inadequate dietary intake and urban lifestyle. |
### Instruction:
Does relationship between Hyperuricemia and Haar-Like feature on Tongue Images?
### Response:
| Symmetrical Haar-like features enabled discrimination of subjects with and without hyperuricemia in our sample. The locations of these discriminative features were in agreement with the interpretation of tongue appearance in traditional Chinese and Western medicine. |
### Instruction:
Do different genetic factors underlie fear conditioning and episodic memory?
### Response:
| Individual differences in fear conditioning and episodic memory reflect distinct genetically influenced processes, suggesting that the genetic risk for learning-induced anxiety disorders includes at least two memory-related genetic factors. These findings are consistent with the facts that the two separate learning forms are distant in their evolutionary development, involve different brain mechanisms, and support that genetically independent memory systems are pivotal in the development and maintenance of syndromes related to fear learning. |
### Instruction:
Does short-Term Caloric Restriction suppress Cardiac Oxidative Stress and Hypertrophy Caused by Chronic Pressure Overload?
### Response:
| Chronic pressure overload increased cardiac oxidative damage, in association with cardiac hypertrophy and fibrosis. Short-term CR suppressed oxidative stress and improved cardiac function, suggesting that short-term CR could be a useful strategy to prevent pressure overload-induced cardiac injury. |
### Instruction:
Does nurse-Enhanced Computerized Cognitive Training Increases Serum Brain-Derived Neurotropic Factor Levels and improve Working Memory in Heart Failure?
### Response:
| Findings support efficacy of Brain Fitness in improving working memory and serum BDNF levels as a biomarker of intervention response. A randomized controlled study is needed among a larger more diverse group of HF patients. |
### Instruction:
Does 14,15-epoxyeicosatrienoic Acid suppress cigarette smoke extract-induced apoptosis in lung epithelial cells by inhibiting endoplasmic reticulum stress?
### Response:
| The data suggest that CYP2J2-derived EETs protect against CSE-induced lung injury possibly through attenuating ER stress. |
### Instruction:
Is diabetes mellitus associated with breast cancer : systematic review , meta-analysis , and in silico reproduction?
### Response:
| Women with DM are at higher risk of BrCa-specific and all-cause mortality after initial breast cancer diagnosis. BrCa patients with DM could possibly benefit from metformin treatment via DICER mediation. |
### Instruction:
Does laparoscopy decrease the laparotomy rate for hemodynamically stable patients with blunt hollow viscus and mesenteric injuries?
### Response:
| Laparoscopy is feasible and safe for hemodynamically stable patients with BHVMIs. |
### Instruction:
Is polymorphism in variable number of tandem repeats of dopamine d4 gene a genetic risk factor in attention deficit hyperactive egyptian children : pilot study?
### Response:
| Children with smaller number of repeat alleles (two to four repeats) of the DRD4 gene have higher possibility to develop ADHD in Egyptian children. |
### Instruction:
Do cancer antigen-125 levels predict long-term mortality in chronic obstructive pulmonary disease?
### Response:
| For the first time, we demonstrated that CA-125 helps the risk stratification of patients with COPD. |
### Instruction:
Is the serum CXCL13 level associated with the Glasgow Prognostic Score in extranodal NK/T-cell lymphoma patients?
### Response:
| Serum levels of CXCL13 were associated with the prognostic value of GPS. Grouping by the serum CXCL13 might predict survival outcomes in patients with ENKTL, suggesting that it is a potential therapeutic target. |
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