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### Instruction:
Does phenotype-dependent alteration of pathways and networks reveal a pure synergistic mechanism for compounds treating mouse cerebral ischemia?
### Response:
| The pure synergism between UA and JA underlies 10 new core pathways and 3 new core functions, which are involved in inflammation, immune responses, apoptosis and nervous system development. |
### Instruction:
Do pallidal and caudate volumes correlate with walking function in multiple sclerosis?
### Response:
| We provide novel evidence of possible SGM structures, particularly the pallidum and perhaps caudate, as correlates of walking performance in MS. |
### Instruction:
Do mathematical optimization of contrast concentration for T1-weighted spoiled gradient echo imaging?
### Response:
| This work provides validated mathematical expressions for contrast enhanced T1-weighted SGRE imaging and may provide guidance for contrast dosing and injection protocols, as well as for novel pulse sequence design. |
### Instruction:
Is the guanylate cyclase-C signaling pathway down-regulated in inflammatory bowel disease?
### Response:
| GUCA2A, GUCA2B and GUCY2C as well as several steps of the GC-C signaling pathway are down-regulated in IBD. This may have implications in IBD pathogenesis. |
### Instruction:
Does nF-κB induce miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma?
### Response:
| These findings uncover a plausible mechanism for NF-κB-sustained TGF-β/Smad activation via miR-148a in glioblastoma, and may suggest a new target for clinical intervention in human cancer. |
### Instruction:
Does post-repolarization refractoriness increase vulnerability to block and initiation of reentrant impulses in heterogeneous infarcted myocardium?
### Response:
| (1) ERP transitions at the NZ-IZ border are abrupt as a consequence of PRR; (2) PRR increases the vulnerability to block and initiation of reentrant impulses in heterogeneous myocardium; (3) V1V2/V2T1 relationships measured at ERP heterogeneities in the computer model and in experimental canine infarcts are not consistent. Therefore, it is likely that other mechanisms like micro and/or macro structural heterogeneities also contribute to initiation of reentrant impulses in infarcted hearts. |
### Instruction:
Does hydrogen inhalation protect against acute lung injury induced by hemorrhagic shock and resuscitation?
### Response:
| Hydrogen, administered through inhalation, may exert potent therapeutic effects against ALI induced by HS/R and attenuate the activation of inflammatory cascades. |
### Instruction:
Does carbon Monoxide Releasing Molecule accelerate Reendothelialization after Carotid Artery Balloon Injury in Rat?
### Response:
| CORM-2 could promote endothelial repair, and inhibit neointima formation after carotid artery balloon injury, which might be associated with the function changes of HUVECs regulated by PI3K/Akt/eNOS pathway. |
### Instruction:
Is high Physical Activity Associated with an Improved Lipid Profile and Resting Heart Rate among Healthy Middle-aged Chinese People?
### Response:
| Our data suggested that substantial health benefits (related to dyslipidemia and elevated RHR) occurred at higher intensity PA, with greater energy consumption, in middle-aged Chinese people, and particularly in men. |
### Instruction:
Does grape Seed Proanthocyanidin Extract alleviate Arsenic-induced Oxidative Reproductive Toxicity in Male Mice?
### Response:
| GSPE alleviates oxidative stress damage in mouse testis by activating Nrf2 signaling, thus counteracting arsenic-induced reproductive toxicity. |
### Instruction:
Does subclinical hypothyroidism in combination with vitamin D deficiency increase the risk of impaired left ventricular diastolic function?
### Response:
| The coexistence of subclinical hypothyroidism with vitamin D deficiency can lead to further deterioration in the LV diastolic function via the regulation of intracellular calcium and induction of inflammatory activity. Therefore, close follow-up of the diastolic functions of these patients could be beneficial. |
### Instruction:
Does imaging correlate of Memory and Concussion History in Retired National Football League Athletes?
### Response:
| Prior concussion that results in loss of consciousness is a risk factor for increased hippocampal atrophy and the development of MCI. In individuals with MCI, hippocampal volume loss appears greater among those with a history of concussion. |
### Instruction:
Does insulin-like growth factor 1 myocardial expression decrease in chronic alcohol consumption?
### Response:
| Chronic alcohol consumption significantly reduces IGF-1 myocardial expression. This decrease induced by alcohol is partially compensated in the presence of structural myocardial damage. |
### Instruction:
Is serum vitamin D level associated with disease severity and response to ursodeoxycholic acid in primary biliary cirrhosis?
### Response:
| 25(OH)D level is associated with biochemical and histological features in PBC. Pre-treatment vitamin D status is independently related to subsequent response to UDCA. Our results suggest that vitamin D status may have important clinical significance in PBC. |
### Instruction:
Does transcranial Magnetic Stimulation Combined with EEG reveal Covert States of Elevated Excitability in the Human Epileptic Brain?
### Response:
| In GGE, the interictal period contains multiple, quasi-stable covert states of excitability a class of which is associated with the generation of TMS-induced EDs. The relevance of these findings to theoretical models of ictogenesis is discussed. |
### Instruction:
Is vosaroxin a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia?
### Response:
| Vosaroxin is a promising new agent in the treatment of AML, with the potential to improve CR rates in a high-risk group of patients with relapsed and refractory AML. However, higher CR rates have been associated with higher rates of treatment-related morbidity and mortality, especially in elderly/unfit patients. Maximising the potential of vosaroxin will therefore require the identification of patients most likely to benefit from vosaroxin-containing combination regimens. |
### Instruction:
Do diploid males support a two-step mechanism of endosymbiont-induced thelytoky in a parasitoid wasp?
### Response:
| Our new model of endosymbiont-induced thelytoky overthrows the view that certain sex determination mechanisms constrain the evolution of endosymbiont-induced thelytoky in hymenopteran insects. Endosymbionts can cause parthenogenesis through feminization, even in groups in which endosymbiont-diploidized eggs would develop into males following the hosts' sex determination mechanism. In addition, our model broadens our understanding of the mechanisms by which endosymbionts induce thelytoky to enhance their transmission to the next generation. Importantly, it also provides a novel window to study the yet-poorly known haplodiploid sex determination mechanisms in haplodiploid insects. |
### Instruction:
Does ancestral reconstruction of reproductive traits show no tendency toward terrestriality in leptodactyline frogs?
### Response:
| Our results found no evidence of evolutionary tendencies toward terrestriality in Leptodactylinae. We found reversals from terrestrial to aquatic tadpole development and no evidence of obligatory intermediate stages, such as semi-terrestrial reproductive strategies. We also found correlations between reproductive modes and other life-history traits driven by water dependence. Aquatic reproductive modes are associated with higher clutch sizes, lentic waters, and the presence of nuptial spines and egg pigmentation. |
### Instruction:
Is use of proton pump inhibitors associated with fractures in young adults : a population-based study?
### Response:
| PPI use was associated with fracture in young adults, but overall evidence did not support a PPI-fracture relationship in children. Young adults who use PPIs should be cautioned regarding potentially increased risk for fracture, even if they lack traditional fracture risk factors. |
### Instruction:
Does up-regulation of the Hippo pathway effector TAZ render lung adenocarcinoma cells harboring EGFR-T790M mutation resistant to gefitinib?
### Response:
| Taken together, this study suggests that expression of TAZ is an intrinsic mechanism of T790M-induced resistance in response to EGFR-TKIs. Combinational targeting on both EGFR and TAZ may enhance the efficacy of EGFR-TKIs in acquired resistance of NSCLC. |
### Instruction:
Is tetrandrine a potent cell autophagy agonist via activated intracellular reactive oxygen species?
### Response:
| Here, we report that tetrandrine is a potent cell autophagy agonist and may have a wide range of applications in the fields of antitumor therapy and basic scientific research. |
### Instruction:
Does treatment with hydrogen molecule attenuate cardiac dysfunction in streptozotocin-induced diabetic mice?
### Response:
| Treatment with hydrogen molecule attenuated cardiac dysfunction in streptozotocin-induced diabetic mice, which was independent of glycemic control. |
### Instruction:
Do tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation?
### Response:
| Tbx5 and Osr1 interact to regulate posterior SHF cell cycle progression for cardiac septation. |
### Instruction:
Does serum miR-181b be Correlated with Hepatitis B Virus Replication and Disease Progression in Chronic Hepatitis B Patients?
### Response:
| Serum miR-181b is correlated with liver and serum HBV DNA levels as well as disease progression in CHB. |
### Instruction:
Do sequence and expression variations suggest an adaptive role for the DA1-like gene family in the evolution of soybeans?
### Response:
| Our work suggested that expression diversification of DA1-like genes is functionally associated with adaptive radiation of soybeans, reinforcing that the plant-specific DA1 gene family might have contributed to the successful adaption to complex environments and radiation of the plants. |
### Instruction:
Does co-expression network of neural-differentiation genes show specific pattern in schizophrenia?
### Response:
| This study supports the relevance of using cellular approaches to dissect molecular aspects of neurogenesis with impact in the schizophrenic brain. We showed that, although generated by different approaches, both sets of DEG associated to schizophrenia were involved with neocortical development. The results add to the hypothesis that critical metabolic changes may be occurring during early neurodevelopment influencing faulty development of the brain and potentially contributing to further vulnerability to the illness. |
### Instruction:
Is serum Matrix Metalloproteinase-7 an independent prognostic biomarker in advanced bladder cancer?
### Response:
| Our results show that the MMP-7 serum concentration is an independent prognostic factor in patients with locally advanced and or metastatic bladder cancer. |
### Instruction:
Is soluble VE-cadherin involved in endothelial barrier breakdown in systemic inflammation and sepsis?
### Response:
| Taken together, formation of sVE-cadherin is associated and contributes to inflammation-induced breakdown of endothelial barrier functions by inhibition of VE-cadherin binding. The underlying mechanism of VE-cadherin cleavage involves ADAM10 and appears to be of clinical relevance since sVE-cadherin was augmented in patients with severe sepsis. |
### Instruction:
Does oral administration of Lactobacillus casei variety rhamnosus partially alleviate TMA-induced atopic dermatitis in mice through improving intestinal microbiota?
### Response:
| LCR35 has the ability to suppress the development of AD in mice, possibly through the modulation of Th1/Th2 balance and gut microbiota. |
### Instruction:
Does [ Epidermal growth factor-like domain 7 promote endothelial cell migration and angiogenesis by activating ERK signaling pathway ]?
### Response:
| EGFL7 effectively promotes migration and angiogenesis through ERK signaling pathway in endothelial cells. |
### Instruction:
Does headache determine quality of life in idiopathic intracranial hypertension?
### Response:
| QOL in IIH patients is significantly reduced. It improved with weight loss alongside significant improvement in clinical measures and headache. However, headache was the only clinical outcome that correlated with enhanced QOL. Effective headache management is required to improve QOL in IIH. |
### Instruction:
Does combining CAL-101 with Celecoxib enhance Apoptosis of EBV-transformed B-Cells Through MAPK-induced ER Stress?
### Response:
| The apoptosis of EBV-transformed B-cells and NHL cells caused by CAL-101 and celecoxib might be related to inhibiting the RHOA/ROCK pathway and might also be associated with mitogen-activated protein kinase (MAPK)-mediated ER stress. |
### Instruction:
Does pentraxin-3 Silencing suppress Gastric Cancer-related Inflammation by Inhibiting Chemotactic Migration of Macrophages?
### Response:
| Our findings suggest that gastric cancer-derived PTX3 promotes macrophage recruitment, which may contribute to gastric cancer-related inflammation. |
### Instruction:
Does kaempferol be an Anti-Inflammatory Compound with Activity towards NF-κB Pathway Proteins?
### Response:
| We conclude that kaempferol possesses anti-inflammatory activity. |
### Instruction:
Do endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature?
### Response:
| Given our findings, we strongly recommend the use of GECs as model cells for brain tumor endothelium for experiments investigating angiogenesis and immunobiology. |
### Instruction:
Do effects of endodontic tri-antibiotic paste on bond strengths of dentin adhesives to coronal dentin?
### Response:
| The etch-and-rinse adhesive Adper Single Bond Plus presented higher mean bond strengths than the self-etch adhesive Filtek P90, irrespective of the group. The superior bond performance for Adper Single Bond when compared to Filtek P90 adhesive was confirmed by a fewer number of adhesive failures. The influence of TAP in bond strength is insignificant. |
### Instruction:
Is physician documentation of sepsis syndrome associated with more aggressive treatment?
### Response:
| Patients whose emergency physicians articulated sepsis syndrome in their documentation or who launched the sepsis order set received antibiotics sooner and received more total volume of fluid. Age <60 and absence of fever are factors associated with lack of recognition of sepsis cases. |
### Instruction:
Does oral zinc supplementation reduce the erythropoietin responsiveness index in patients on hemodialysis?
### Response:
| Zinc supplementation reduces ERI in patients undergoing HD and may be a novel therapeutic strategy for patients with renal anemia and low serum zinc levels. |
### Instruction:
Is components separation technique feasible for assisting delayed primary fascial closure of open abdomen?
### Response:
| Components separation is a useful method in contributing to successful primary fascial closure in patients treated for open abdomen. Best results were obtained when components separation was performed simultaneously with primary fascial closure at the end of the open abdomen treatment. |
### Instruction:
Are female third party lymphocytes effective for immunotherapy of patients with unexplained primary recurrent spontaneous abortion : A retrospective analysis of outcomes?
### Response:
| We conclude that female third party lymphocytes can be used for immunotherapy in patients with recurrent spontaneous abortion. |
### Instruction:
Does acute but not chronic activation of brain glucagon-like peptide-1 receptors enhance glucose-stimulated insulin secretion in mice?
### Response:
| Our results indicate that, under non-clamped conditions, brain GLP-1 plays a functional neuroendocrine role in the acute regulation of glucose homeostasis in both lean and obese rodents. |
### Instruction:
Is activation of natriuretic peptides and the sympathetic nervous system following Roux-en-Y gastric bypass associated with gonadal adipose tissues browning?
### Response:
| Upregulation of Nppb, Npr1, Npr2, and β3-adrenergic receptors in gonadal adipose tissue following RYGB was associated with increased markers of browning. This browning of gonadal adipose tissue may underpin the positive effect of RYGB on metabolic parameters and may in part be mediated through upregulation of natriuretic peptides. |
### Instruction:
Does rituximab lead to long remissions in patients with chronic immune thrombocytopenia?
### Response:
| The use of rituximab in ITP achieves high response rate and long remission duration. Our study was limited by the small sample size and further larger prospective studies are recommended. |
### Instruction:
Is bordetella pertussis an uncommon pathogen in children hospitalized with bronchiolitis during the winter season?
### Response:
| Our data support that B. pertussis is an uncommon pathogen in U.S. children hospitalized with bronchiolitis in the winter. Making a diagnosis of pertussis can be challenging because the disease can be atypical and may not meet the Centers for Disease Control and Prevention definition of probable infection. |
### Instruction:
Is continuous minimally invasive cardiac output monitoring with the COstatus in a neonatal swine model : recalibration necessary during vasoconstriction and vasodilation?
### Response:
| Continuous cardiac output (CO) measured with the COstatus monitor requires recalibration during vasoconstriction and vasodilation, even if changes in COTPUD or SVR are not substantial. |
### Instruction:
Is hepatic steatosis associated with lower levels of physical activity measured via accelerometry?
### Response:
| There is an inverse association between PA and hepatic steatosis. Participants who met the national PA guidelines had the lowest prevalence of hepatic steatosis. |
### Instruction:
Do ecological evidence that affect and perceptions of drink effects depend on alcohol expectancies?
### Response:
| Although theoretical models tend to focus on negative affective outcomes of drinking, changes in positive affect prior to drinking and early in drinking episodes are important for maintaining drinking behavior. Frequent drinkers' expectations for enhanced sociability or tension reduction from drinking influence their affective experiences over drinking days and perceptions of pleasure and relief from drinking. |
### Instruction:
Does pharmacokinetic synergy from the taxane extract of Taxus chinensis improve the bioavailability of paclitaxel?
### Response:
| Together, these results support that administration of PTX in the form of taxane mixtures may become a novel approach to improve the poor bioavailability of PTX. Moreover, the inherent synergy from Taxus chinensis taxane extracts promises a novel strategy to strengthen PTX efficacy. |
### Instruction:
Does marsdenia tenacissima extract enhance gefitinib efficacy in non-small cell lung cancer xenografts?
### Response:
| The present results suggest that the combination of MTE and gefitinib may be a promising therapeutic approach to enhance gefitinib efficacy in resistant NSCLC. |
### Instruction:
Do peripheral blood mononuclear cells from severe asthmatic children release lower amounts of IL-12 and IL-4 after LPS stimulation?
### Response:
| Our results demonstrate that LPS directly influence the cytokine profile of PBMC in children with severe asthma. These observations may be potentially helpful in developing new treatment strategies. |
### Instruction:
Is plasma oligomeric alpha-synuclein associated with glucocerebrosidase activity in Gaucher disease?
### Response:
| The decrease in GBA activity may influence α-Syn oligomerization, explaining the high risk of PD development in GD patients. © 2015 International Parkinson and Movement Disorder Society. |
### Instruction:
Do influence of torsional strength on different types of dental implant platforms?
### Response:
| For all the implants, high insertion torques deformed the implant platform preventing long-term maintenance and stability of implants. |
### Instruction:
Does glutamine restore Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome?
### Response:
| Glutamine increased claudin-1 expression in the colonic mucosa of patients with IBS-D. In addition, glutamine effect seems to be dependent on basal expression of tight junction proteins. |
### Instruction:
Does surgical result after unilateral laminectomy for the removal of spinal cord tumors?
### Response:
| UL is an optimal approach for providing sufficient exposure of spinal cord tumors without development of postoperative spinal instability and regional sagittal imbalance in any location of spinal column. In cases of meningioma, careful long-term follow up is needed due to it's relatively high recurrence rate after removal via UL. |
### Instruction:
Does cOPART Risk Score predict Long-term Mortality in Peripheral Arterial Occlusive Disease?
### Response:
| The COPART Risk Score is a suitable instrument to predict long-term all cause and CV mortality in claudicants preceding their first peripheral intervention. |
### Instruction:
Is expression of bone morphogenetic proteins 4 , 6 and 7 downregulated in kidney allografts with interstitial fibrosis and tubular atrophy?
### Response:
| The intensity and expression pattern of BMP4, BMP6 and BMP7 in transplanted kidney tissue are found to be dependent upon the length of the transplanted period, the clinical indication for transplant nephrectomy and signs of IFTA in kidney tissue. |
### Instruction:
Does the temporal expression pattern of alpha-synuclein modulate olfactory neurogenesis in transgenic mice?
### Response:
| The dissociation between higher absolute expression levels of alpha-Synuclein but less severe impact on adult olfactory neurogenesis in mThy1 transgenic mice highlights the importance of temporal expression characteristics of alpha-Synuclein on the maturation of newborn neurons. |
### Instruction:
Does lichen endophyte derived pyridoxatin inactivate Candida growth by interfering with ergosterol biosynthesis?
### Response:
| PYR interferes with the ergosterol synthesis to exert antifungal action. |
### Instruction:
Does carotid sparing intensity-modulated radiation therapy achieve comparable locoregional control to conventional radiotherapy in T1-2N0 laryngeal carcinoma?
### Response:
| These results warrant further prospective evaluation of CS-IMRT for early-stage glottic larynx cancer. |
### Instruction:
Does severe Obesity in Adolescents and Young Adults be Associated With Subclinical Cardiac and Vascular Changes?
### Response:
| Adolescents and young adults with severe obesity have a more adverse cardiovascular risk profile and worse cardiac and vascular structure and function. More importantly, severe obesity is independently associated with these subclinical cardiac and vascular changes. |
### Instruction:
Is a smaller amygdala associated with anxiety in Parkinson 's disease : a combined FreeSurfer-VBM study?
### Response:
| These results confirm studies in non-PD samples showing lower left amygdalar volume in anxious patients. The results also indicate that the 'psychological' BAI subscale is a better reflection of neural correlates of anxiety in PD. Whether the left amygdalar volume decrease constitutes a premorbid trait, a PD-associated neurobiological susceptibility to anxiety or arises as a consequence of chronic anxiety symptoms remains to be determined by future prospective longitudinal studies. Nonetheless, we speculate that the Parkinson pathology is responsible for the reduction in amygdalar volume and the concomitant development of anxiety symptoms. |
### Instruction:
Is cyst Fluid Glucose Rapidly Feasible and Accurate in Diagnosing Mucinous Pancreatic Cysts?
### Response:
| Glucose, whether measured by a laboratory assay, a glucometer, or a reagent strip, is significantly lower in mucinous cysts compared with non-mucinous pancreatic cysts. |
### Instruction:
Do a User-Developed 3-D Hand Gesture Set for Human-Computer Interaction?
### Response:
| A method is proposed for generating a user-developed 3-D gesture lexicon for common HCIs that involves subjective ratings and a posture risk rating for minimizing arm and hand fatigue. |
### Instruction:
Does an iterative approach to respiratory self-navigated whole-heart coronary MRA significantly improve image quality in a preliminary patient study?
### Response:
| An iterative approach to respiratory motion correction in self-navigation may lead to significant improvements in coronary MRA image quality in patients with a less consistent end-expiratory respiratory phase. |
### Instruction:
Is hIV infection associated with an increased prevalence of coronary noncalcified plaque among participants with a coronary artery calcium score of zero : Multicenter AIDS Cohort Study ( MACS )?
### Response:
| Among men with CAC scores of zero, HIV infection is associated with an increased prevalence of noncalcified coronary plaque independent of traditional cardiovascular risk factors. This finding suggests that CAC scanning may underestimate plaque burden in HIV-infected men. |
### Instruction:
Are free thyroxine levels associated with cognitive abilities in subjects with early psychosis?
### Response:
| Our study suggests that FT4 levels are associated with cognitive abilities (attention/vigilance and overall cognition) in individuals with early psychosis. |
### Instruction:
Is neighborhood socioeconomic status associated with violent reinjury?
### Response:
| For young patients injured by violence, the socioeconomic position of their neighborhood of residence is independently correlated with their risk of violent reinjury. Low neighborhood socioeconomic status may be associated with a disrupted sense of safety after injury and also may alter a person's likelihood of engaging in behaviors correlated with recurrent violent injury. Programs aimed at reducing violent injury recidivism should address needs at the individual and neighborhood level. |
### Instruction:
Are trauma systems associated with increased level 3 trauma centers?
### Response:
| Our study shows that the number of level 3 TCs significantly and independently correlated with the presence of a funded trauma system. The number of level 1 and 2 centers showed no such correlation. Further study will determine if increased number of level 3 centers leads to improved clinical outcome. |
### Instruction:
Do gastric cancer-derived mesenchymal stem cells prompt gastric cancer progression through secretion of interleukin-8?
### Response:
| Tumor-resident GC-MSCs promote gastric cancer growth and progression more efficiently than GCN-MSCs or BM-MSCs through a considerable secretion of IL-8, which could be a possible target for gastric cancer therapy. |
### Instruction:
Does cell-to-cell contact facilitate HIV transmission from lymphocytes to astrocytes via CXCR4?
### Response:
| Cell-to-cell transmission was mediated by a unique mechanism by which immature viral particles initiated a fusion process in a CXCR4-dependent, CD4-independent manner. These observations have important implications for developing approaches to prevent formation of HIV reservoirs in the brain. |
### Instruction:
Does moderate physical training attenuate perinatal low-protein-induced spleen lymphocyte apoptosis in endotoxemic adult offspring rats?
### Response:
| Moderate physical training was able to revert the effects of perinatal LP diet on circulation lymphocytes subsets and attenuated splenic lymphocytes apoptosis and plasma TNF-α concentrations. |
### Instruction:
Does bAFF promote proliferation of human mesangial cells through interaction with BAFF-R?
### Response:
| BAFF promoted proliferation of human mesangial cells, which was mediated via BAFF-R. The BAFF/BAFF-R interaction triggered Akt, p65 and p38 activation, with Akt phosphorylation being tightly dependent on BAFF/BAFF-R interaction. |
### Instruction:
Is protein Phosphatase 1 Beta Modulated by Chronic Hypoxia and Involved in the Angiogenic Endothelial Cell Migration?
### Response:
| PP1cβ is regulator of endothelial cell migration, which is critical in the angiogenic process. PP1cβ inhibition reduces endothelial cell migration through focal adhesion turnover and actin polymerization pathways. |
### Instruction:
Does dexmedetomidine attenuate blood-spinal cord barrier disruption induced by spinal cord ischemia reperfusion injury in rats?
### Response:
| Dexmedetomidine preconditioning stabilized the BSCB integrity against spinal cord I/R injury by inhibition of MMP-9, and enhancing the Ang1-Tie2 system. |
### Instruction:
Does baicalein inhibit MMPs Expression via a MAPK-Dependent Mechanism in Chondrocytes?
### Response:
| The results indicate that baicalein may be considered as a potential agent for OA treatment. |
### Instruction:
Does cinnamaldehyde prevent endothelial dysfunction induced by high glucose by activating Nrf2?
### Response:
| Our results indicated that CA protected endothelial dysfunction under high glucose conditions and this effect was mediated by Nrf2 activation and the up-regulation of downstream target proteins. CA administration may represent a promising intervention in diabetic patients who are at risk for vascular complications. |
### Instruction:
Does low left atrial appendage flow velocity predict recurrence of atrial fibrillation after catheter ablation of persistent atrial fibrillation?
### Response:
| A low LAAV was associated with AF recurrence after the initial catheter ablation of persistent AF. |
### Instruction:
Is polymorphisms of rs174616 in the FADS1-FADS2 gene cluster associated with a reduced risk of type 2 diabetes mellitus in northern Han Chinese people?
### Response:
| These data suggest that in northern Han Chinese people, the minor allele (T) of rs174616 in the FADS1-FADS2 gene cluster is associated with a decreased conversion rate of LA to AA, which may contribute to decreased reduced risk of developing T2DM. |
### Instruction:
Does bile acid binding resin improve hepatic insulin sensitivity by reducing cholesterol but not triglyceride levels in the liver?
### Response:
| BAR improved hepatic insulin resistance in FLS mice by reducing hepatic cholesterol without affecting hepatic triglyceride levels or body fat distribution. Our study revealed that BAR improves glycaemic control at least in part by downregulating the hepatic cholesterol-LXR-IRS2 pathway. |
### Instruction:
Is no evidence that genetically reduced 25-hydroxyvitamin D associated with increased risk of ischaemic heart disease or myocardial infarction : a Mendelian randomization study?
### Response:
| We found no evidence to suggest that genetically reduced p-25(OH)D is associated with increased risk of ischaemic heart disease or myocardial infarction. |
### Instruction:
Does acoustic feature for the Identification of Coronary Artery Disease?
### Response:
| The result confirms that there is a potential in heart sounds for the diagnosis of CAD, but that further improvements are necessary to gain clinical relevance. |
### Instruction:
Is co-administration of α-lipoic acid and glutathione associated with no significant changes in serum bilirubin , alkaline phosphatase or γ-glutamyltranspeptidase levels during the treatment of neuroborreliosis with intravenous ceftriaxone?
### Response:
| Co-administration of α-lipoic acid and glutathione is associated with no significant changes in serum bilirubin, alkaline phosphatase or γ-glutamyltranspeptidase levels during the treatment of neuroborreliosis with intravenous ceftriaxone. |
### Instruction:
Is oncostatin M a potential agent for the treatment of obesity and related metabolic disorders : a study in mice?
### Response:
| We showed that OSM is a novel candidate to act as a powerful therapeutic agent for the treatment of obesity-induced metabolic disorders. |
### Instruction:
Is systemic oxidative stress to nucleic acids unaltered following radioiodine therapy of patients with benign nodular goiter?
### Response:
| Systemic oxidative stress, as detected by nucleic acids metabolites in the urine, is not increased after thyroid stimulation with 0.1 mg of rhTSH, or after (131)I therapy. Our method cannot quantify the oxidative stress induced locally in the thyroid gland, but the study supports that (131)I therapy of benign nodular goiter carries no or only a minute risk of developing subsequent malignancies. It remains to be explored whether our findings also apply to hyperthyroid disorders. |
### Instruction:
Does anemia be a Risk Factor of New Intraoperative Hemorrhagic Stroke During Valve Surgery for Endocarditis?
### Response:
| Intraoperative hemorrhagic stroke was not rare, and ectopic hemorrhagic stroke, associated with preoperative anemia, was more prevalent than hemorrhagic transformation of existing cerebral lesions. |
### Instruction:
Is thromboembolic disease after knee arthroplasty rare in Southern Iran?
### Response:
| No clinically significant DVT was found using either enoxaparin or warfarin prophylaxis after TKA in Southern Iran. Relatively excessive postoperative bleeding was observed, particularly with enoxaparin. |
### Instruction:
Does gemcitabine induce Radiosensitization Through Inhibition of RAD51-dependent Repair for DNA Double-strand Breaks?
### Response:
| RAD51-dependent homologous recombination is one of the key targets in the GEM-induced radiosensitizing effect. |
### Instruction:
Does aquaporin 3 Expression predict Survival in Patients with HER2-positive Early Breast Cancer?
### Response:
| AQP3 expression in tumor tissue may be considered as a potential prognostic marker in patients with HER2-over-expressing EBC after curative surgery. |
### Instruction:
Does microarray transcriptional profiling of Arctic Mesorhizobium strain N33 at low temperature provide insights into cold adaption strategies?
### Response:
| Our analysis revealed a complex series of changes associated with cold exposure adaptation and constant growth at low temperatures. Moreover, it highlighted some of the strategies and different physiological states that Mesorhizobium strain N33 has developed to adapt to the cold environment of the Canadian high Arctic and has revealed candidate genes potentially involved in cold adaptation. |
### Instruction:
Are eRRγ target genes poor prognostic factors in Tamoxifen-treated breast cancer?
### Response:
| ERRγ signaling is associated with poor DMFS in ER+, TAM-treated breast cancer, and ESRRG, EEF1A2, and PPIF comprise a 3-gene signaling node that may contribute to TAM resistance in the context of an active ERK/MAPK pathway. |
### Instruction:
Does adenosine testing after second-generation cryoballoon ablation ( ATSCA ) study improve clinical success rate for atrial fibrillation?
### Response:
| Adenosine testing after second-generation cryoballoon ablation study showed that reablation of initially isolated PVs increases the clinical success rate for AF. |
### Instruction:
Does the ratio of the neutrophil leucocytes to the lymphocytes predict the outcome after cardiac resynchronization therapy?
### Response:
| The NL ratio is elevated in chronic heart failure and predicts outcome after CRT. According to the reclassification analysis, 4% of the patients would have been better categorized in the prediction models by combining the NT-proBNP with the NL ratio. Thus, a single blood count measurement could facilitate the optimal patient selection for the CRT. |
### Instruction:
Are changes in Autonomic Nervous System Activity Associated with Changes in Sexual Function in Women with a History of Childhood Sexual Abuse?
### Response:
| Treatments that reduce autonomic imbalance may improve sexual well-being among CSA populations. |
### Instruction:
Is eukaryotic translation elongation factor-1 alpha associated with a specific subset of mRNAs in Trypanosoma cruzi?
### Response:
| These results indicate that in T. cruzi, as in other eukaryotes, EF-1α may play a non-canonical cellular role. We observed the enrichment of functionally related transcripts bound to EF-1α in normal growth conditions as well as in nutritionally stressed cell indicating a potential role of EF-1α mRNP in stress response. |
### Instruction:
Is early arrival at the emergency department associated with better collaterals , smaller established infarcts and better clinical outcomes with endovascular stroke therapy : SWIFT study?
### Response:
| Time was a critical factor in successful clinical outcomes for neurothrombectomy in the SWIFT trial. Shorter times to presentation were associated with better collaterals, smaller established infarcts, and better clinical outcome after revascularization. |
### Instruction:
Does the effect of exercise on exhaled nitric oxide depend on allergic rhinoconjunctivitis in children?
### Response:
| The impact of exercise on FENO was dependent on the allergic phenotype, regardless of asthma status. FENO decreased immediately after exercise, and did not return to baseline level within 30 min. |
### Instruction:
Does neonatal DTI early after birth predict motor outcome in preterm infants with periventricular hemorrhagic infarction?
### Response:
| DTI in preterm infants with PVHI within a few weeks after birth is associated with later motor development. |
### Instruction:
Is eDIL3 a novel regulator of epithelial-mesenchymal transition controlling early recurrence of hepatocellular carcinoma?
### Response:
| EDIL3-mediated activation of TGF-β and ERK signaling could provide therapeutic implications for HCC. |
### Instruction:
Is mechanical dyssynchrony additive to ECG criteria and independently associated with reverse remodelling and clinical response to cardiac resynchronisation therapy in patients with advanced heart failure?
### Response:
| Radial dyssynchrony was associated with significant improvements in LVESV and clinical outcomes following CRT and is independent of QRS duration or morphology, and additive to current ECG selection criteria to predict response to CRT. |
### Instruction:
Does the Ohmmeter identify the Site of Fluid Leakage during Artificial Urinary Sphincter Revision Surgery?
### Response:
| In cases of suspected fluid loss as a cause of artificial urinary sphincter malfunction an ohmmeter can identify the site of fluid loss during component revision surgery. |
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