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### Instruction:
Is baseline Perineural Invasion Associated with Shorter Time to Progression in Men with Prostate Cancer Undergoing Active Surveillance : Results from the REDEEM Study?
### Response:
| Among patients with prostate cancer on active surveillance perineural invasion was associated with an increased risk of clinical progression. The 2-year risk of clinical progression with perineural invasion was 73%. If these results are confirmed, patients with perineural invasion may not be good active surveillance candidates. |
### Instruction:
Do wnt blockers inhibit the proliferation of lung cancer stem cells?
### Response:
| Wnt signaling inhibitor PP can inhibit proliferation of LCSCs, and the Wnt signaling pathway could be considered a promising therapeutic or interventional target in lung adenocarcinoma. |
### Instruction:
Does carcinogenic Liver Fluke secrete Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype?
### Response:
| This is the first time that EVs from a multicellular pathogen have been identified in host tissues. Our findings imply a role for O. viverrini EVs in pathogenesis and highlight an approach to vaccine development for this infectious cancer. |
### Instruction:
Does dichotomous `` Good Outcome '' indicate Mobility More Than Cognitive or Social Quality of Life?
### Response:
| Health-related quality of life assessments reliably distinguished between good and poor outcomes as determined by the modified Rankin Scale. Good outcome indicated health-related quality of life about 1.5 SD below the U.S. population mean. Associations were weaker for cognitive function and social function than mobility. |
### Instruction:
Does loss of Bace1 in mice alter the severity of caerulein induced pancreatitis?
### Response:
| We discuss the results in the context of the applied caerulein induced edematous pancreatitis model and possible compensatory mechanisms via Bace2 that might be responsible for the observed results. |
### Instruction:
Is non-extracorporeal circulation for coronary artery bypass graft surgery more beneficial than extracorporeal circulation?
### Response:
| Extracorporeal circulation prolongs operation and can aggravate systemic inflammatory response. Therefore, CABG with non-extracorporeal circulation offers more beneficial outcomes. |
### Instruction:
Does white Matter Damage relate to Oxygen Saturation in Children With Sickle Cell Anemia Without Silent Cerebral Infarcts?
### Response:
| These data show widespread white matter abnormalities in a sample of asymptomatic children with sickle cell anemia, and provides for the first time direct evidence of a relationship between brain microstructure and markers of disease severity (eg, peripheral oxygen saturation and steady-state hemoglobin). This study suggests that diffusion tensor imaging metrics may serve as a biomarker for future trials of reducing hypoxic exposure. |
### Instruction:
Does neutrophil-to-Lymphocyte Ratio be Associated with Impaired Interferon-Gamma Release to Phytohemagglutinin?
### Response:
| We showed that the NLR is an independent predictor of indeterminate QFT-GIT result. Low frequency of indeterminate results in group with normal NLR may imply the importance of a balance between two cellular compartments in physiological and pathological conditions. |
### Instruction:
Does intravitreal inhibition of complement C5a reduce choroidal neovascularization in mice?
### Response:
| Our findings demonstrate that the targeted inhibition of complement component C5a reduces vascular leakage and neovascular area in laser-induced CNV in mice. NOX-D20 was proven to be an effective and safe agent that might be considered as a therapeutic candidate for CNV treatment. The deficiency of activated immune cells highlights promising new aspects in the pathology of choroidal neovascularization, and warrants further investigations. |
### Instruction:
Is brain tumor a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition?
### Response:
| Our results represent the first genome-wide analysis of the mRNAs associated with a TRIM-NHL protein and the first identification of an RNA motif bound by this protein family. BRAT is a prominent post-transcriptional regulator in the early embryo through mechanisms that are largely independent of PUM. |
### Instruction:
Does improvement of Bovine Nucleus Pulposus Cells Isolation lead to Identification of Three Phenotypically Distinct Cell Subpopulations?
### Response:
| This study demonstrated that collagenase-type-XI is an efficient enzyme that is used for digesting bNP. And most importantly, three phenotypically distinct subpopulations of cells where identified within the bNP. Such knowledge is key for a better understanding of NP cell biology and its potential endogenous regenerative capacity. |
### Instruction:
Does carotid intima-media thickness measurement promise to improve cardiovascular risk evaluation in head and neck cancer patients?
### Response:
| Carotid IMT identified a much greater percentage of radiation-treated HNC patients at high CV risk compared with standard CV-risk calculators. By more accurately identifying the patients at high risk, this may lead to more effective prevention, and therefore a reduction in CV events. |
### Instruction:
Does gCKR polymorphism influence liver fat content in patients with type 2 diabetes?
### Response:
| This study shows that in patients with type 2 diabetes who were not selected for liver abnormalities, liver fat content was related to GCKR rs1260326 polymorphism independent of BMI, triglyceride levels, and age. |
### Instruction:
Are most partial domains in proteins alignment and annotation artifacts?
### Response:
| Partial domains are largely the result of alignment and annotation artifacts and should be viewed with caution. The presence of partial domain annotations in proteins should raise the concern that the prediction of the protein's gene may be incomplete. In general, protein domains can be considered the structural building blocks of proteins. |
### Instruction:
Does anacetrapib lower LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects?
### Response:
| These data indicate that anacetrapib, given alone or in combination with a statin, reduces LDL-ApoB-100 levels by increasing the rate of ApoB-100 fractional clearance. |
### Instruction:
Is adequate enteral protein intake inversely associated with 60-d mortality in critically ill children : a multicenter , prospective , cohort study?
### Response:
| Delivery of >60% of the prescribed protein intake is associated with lower odds of mortality in mechanically ventilated children. Optimal prescription and modifiable practices at the bedside might enhance enteral protein delivery in the PICU with a potential for improved outcomes. This trial was registered at clinicaltrials.gov as NCT02354521. |
### Instruction:
Does systemic Inflammatory Response Syndrome predict Severity of Stroke and Outcome?
### Response:
| SIRS at presentation is a useful marker for clinicoradiological severity of stroke but not an independent marker of death and disability. |
### Instruction:
Do lipid-based nutrient supplements affect efavirenz but lower plasma nevirapine concentrations in Ethiopian adult HIV patients?
### Response:
| Intake of an LNS was associated with lower plasma nevirapine trough concentrations, indicating possible drug-LNS interactions. The clinical relevance of such reductions in nevirapine exposure is not clear. Plasma efavirenz concentration was not affected by the LNS. |
### Instruction:
Are paraoxonase ( PON1 ) polymorphisms Q192R and L55M associated with human longevity : A meta-analysis?
### Response:
| No evidence that the Q192R and L55M polymorphisms of PON1 impacted on the probability of reaching extreme ages was found although this cannot be completely ruled out; however, the possibility of population-specific effects due to the influence of and interaction between different genes or environmental factors could not be ruled out. |
### Instruction:
Does deficiency of MMP17/MT4-MMP proteolytic activity predispose to aortic aneurysm in mice?
### Response:
| Mmp17 proteolytic activity regulates vascular smooth muscle cell phenotype in the arterial vessel wall, and its absence predisposes to thoracic aortic aneurysm in mice. The rescue of part of the vessel-wall phenotype by a lentiviral strategy opens avenues for therapeutic intervention in these life-threatening disorders. |
### Instruction:
Does heparin enhance uptake of platelet factor 4/heparin complexes by monocytes and macrophages?
### Response:
| Taken together, these studies establish a distinct role for heparin in enhancing antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes. |
### Instruction:
Does clinician-delivered contingency management increase engagement and attendance in drug and alcohol treatment?
### Response:
| Findings support the feasibility and effectiveness of a CM intervention delivered by clinicians for increasing treatment attendance and utilization in a community substance abuse program. |
### Instruction:
Does high Expression of Matrix Metalloproteinase-11 indicate Poor Prognosis in Human Cholangiocarcinoma?
### Response:
| The positive MMP-11 expression indicates poor prognosis in CHCA specimens. |
### Instruction:
Do comparative proteomics and global genome-wide expression data implicate role of ARMC8 in lung cancer?
### Response:
| The findings in this report are suggestive of a regulatory role of ARMC8 in control of proliferation and differentiation in lung adenocarcinomas. |
### Instruction:
Does reduction of Mitochondria-Endoplasmic Reticulum Interactions by Acetylcholine protect Human Umbilical Vein Endothelial Cells From Hypoxia/Reoxygenation Injury?
### Response:
| Our data suggest that ER-mitochondria interplay plays an important role in reperfusion injury in the endothelium and may be a novel molecular target for endothelial protection. Acetylcholine attenuates both intracellular and mitochondrial Ca(2+) overload and protects endothelial cells from H/R injury, presumably by disrupting the ER-mitochondria interaction. |
### Instruction:
Does sleep influence the intracerebral EEG pattern of focal cortical dysplasia?
### Response:
| Despite the presence of an almost continuous discharge, sleep is an important modulator of the pathological EEG patterns found in FCD type II. This might suggest that dysplastic tissue is influenced by the thalamo-cortical control mechanisms involved in the generation of sleep. |
### Instruction:
Does autophagy protect renal tubular cells against ischemia / reperfusion injury in a time-dependent manner?
### Response:
| Autophagy was induced in a time-dependent manner and occurred earlier than the onset of cell apoptosis as an early response that played a renoprotective role during renal I/R and cell H/R. Up-regulation of autophagy may prove to be a potential strategy for the treatment of acute kidney injury. |
### Instruction:
Does chronic-leptin attenuate Cisplatin cytotoxicity in MCF-7 breast cancer cell line?
### Response:
| Chronic leptin could contribute to the effective regulation of endogenous and treatment-induced oxidative stress, and it contributes to explain in part its proliferative effects. |
### Instruction:
Does the Precision of Pulmonary Artery Catheter Bolus Thermodilution Cardiac Output Measurements vary With the Clinical Situation?
### Response:
| Clinical precision of cardiac output measurements is reduced significantly during spontaneous relative to controlled ventilation. The differences in precision between repeated measurement series within the temperature/ventilation combinations indicate influence of other situation-specific factors not related to ventilatory mode. Compared with tepid injectate in patients breathing spontaneously, the precision is 3-fold better with cold injectate and controlled ventilation. |
### Instruction:
Is plasma heat shock protein 27 increased in renal dysfunction and habitual smoking in a Japanese general population?
### Response:
| The present study demonstrated that HSP 27 levels were strongly related to renal dysfunction and habitual smoking in a dose-response manner in a Japanese general population. |
### Instruction:
Is occupancy by key transcription factors a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility?
### Response:
| Occupancy by key transcription factors such as TAL1, GATA1, SMAD1, and EP300, along with evidence of transcription, improves the accuracy of enhancer predictions based on epigenetic features. |
### Instruction:
Does automated nutrient screening system enable high-throughput optimisation of microalgae production conditions?
### Response:
| The screen identified the main nutrient effects on growth, pairwise nutrient interactions (for example, Ca-Mg) and the best production conditions of the sampled statistical space providing the basis for a targeted full factorial screen to assist with optimisation of algae production. |
### Instruction:
Does a modified Glenn shunt reduce right ventricular stroke work during left ventricular assist device therapy?
### Response:
| A modified Glenn shunt reduced RV volumes, RV stroke work and RA pressure during LVAD therapy in an experimental model of heart failure in pigs. |
### Instruction:
Does twice cutting method reduce tibial cutting error in unicompartmental knee arthroplasty?
### Response:
| Our study demonstrated that in UKA, cutting the tibia horizontally twice using the same cutting guide reduced cutting error in the coronal plane. |
### Instruction:
Does preventive methylene blue treatment preserve cognition in mice expressing full-length pro-aggregant human Tau?
### Response:
| Our data support the use of Tau aggregation inhibitors as potential drugs for the treatment of AD and other tauopathies and highlights the need for preventive treatment before onset of cognitive impairments. |
### Instruction:
Are pragmatic characteristics of patient-reported outcome measures important for use in clinical practice?
### Response:
| Balancing psychometric and pragmatic factors in the development of PROs is important for accelerating the incorporation of PROs into clinical practice. |
### Instruction:
Does clipping of tumour resection margins allow accurate target volume delineation in head and neck cancer adjuvant radiation therapy?
### Response:
| We demonstrate a precise delineation of the former tumour cavity. Improvements in tumour bed delineation allow an increase of accuracy for adjuvant treatment. |
### Instruction:
Does boredom proneness predict quality of life in outpatients diagnosed with schizophrenia-spectrum disorders?
### Response:
| This pattern of unique effects on quality of life highlights the clinical relevance of identifying a subjective state of boredom and has theoretical importance in distinguishing boredom proneness specifically from more general avolitional and amotivational conditions that have tended to be the focus of clinical observation and previous research. |
### Instruction:
Do frequency steps and compositions determine properties of nee- dling sensation during electroacupuncture?
### Response:
| The greater the frequency step of the electroacupuncture stimulation, the longer the needling sensation lasted. The electroacupuncture stimulations of the DD3 group were unsuitable for the facial acupoint because of its painful and uncomfortable EAS, but more suitable for the back acupoint. |
### Instruction:
Does aNXA1 silencing increase the sensitivity of cancer cells to low-concentration arsenic trioxide treatment by inhibiting ERK MAPK activation?
### Response:
| Taken together, these data indicate that overexpression of ANXA1 induced by low-concentration ATO makes cancer cells more resistant to the agent via activated ERK MAPKs. Specific silencing of ANXA1 increased the sensitivity of cancer cells to ATO treatment. |
### Instruction:
Does topical dexamethasone-cyclodextrin nanoparticle eye drop for non-infectious Uveitic macular oedema and vitritis - a pilot study?
### Response:
| This short pilot study demonstrates favourable effect of 1.5% DexNP eye drops on eyes with non-infectious uveitic macular oedema and vitritis. Further comparative long-term studies are warranted to assess this effect. |
### Instruction:
Does temporal-component analysis of diastolic electrograms in ventricular tachycardia differentiate nonvulnerable regions of the circuit?
### Response:
| Our analysis suggests that temporal-component analysis of diastolic electrograms during activation mapping of VT provides a practical method to differentiate nonvulnerable sites from the exit site without the need for pacing maneuvers. |
### Instruction:
Does post-operative plasma osteopontin predict distant metastasis in human colorectal cancer?
### Response:
| The results of the current study suggest that post-operative plasma OPN correlated with post-operative metastasis, suggesting that it is a potential non-invasive biomarker for the development of future metastasis in CRC patients. In addition, OPN was shown to be involved in the metastatic process and thus inhibition of OPN is a potential therapeutic approach to treat CRC patients. |
### Instruction:
Are not all gleason pattern 4 prostate cancers created equal : A study of latent prostatic carcinomas in a cystoprostatectomy and autopsy series?
### Response:
| Our study revealed that in latent prostate cancer both cribriform architecture and IDC are uniquely associated with poor pathological outcome features. In contrast, Gleason score 7 (3 + 4) cancers with small-fused gland pattern might possibly include some prostate cancers with a more indolent biology. |
### Instruction:
Are serum IL-33 levels increased in patients with psoriasis?
### Response:
| These results suggest that serum IL-33 levels generally reflect increased inflammation in patients with psoriasis. |
### Instruction:
Does gene expression profiling reveal potential prognostic biomarkers associated with the progression of heart failure?
### Response:
| This study demonstrates an altered gene expression profile in PBMCs during acute myocardial infarction and through the follow-up. The identified gene expression changes at the early phase of STEMI that differentiated the patients who developed HF from those who did not could serve as a convenient tool contributing to the prognosis of heart failure. |
### Instruction:
Does pharmacotherapy with 17β-estradiol and progesterone prevent development of mouse experimental autoimmune encephalomyelitis?
### Response:
| Cotherapy with estrogen and progesterone inhibits the development of major neurochemical abnormalities and clinical signs of EAE. We suggest that a combination of neuroprotective, promyelinating and immuno-suppressive mechanisms are involved in these beneficial effects. |
### Instruction:
Does high Expression of GRP78 promote Invasion and Metastases in Patients with Esophageal Squamous Cell Carcinoma?
### Response:
| The present study demonstrated that GRP78 plays important roles in invasion and metastasis of ESCC, indicating that GRP78 might be used as a potential prognostic and therapeutic marker in patients with ESCC by modulating the expression of MMP-2 and MMP-9. |
### Instruction:
Are patients with single ventricle physiology undergoing noncardiac surgery at high risk for adverse events?
### Response:
| We observed no mortality during or after noncardiac surgery in a high-risk subgroup of palliated cardiac patients with single ventricle physiology. However, 11.8% of patients had an adverse event associated with their anesthetic. |
### Instruction:
Is the histone deacetylase sirtuin 2 a new player in the regulation of platelet function?
### Response:
| Regulation of protein acetylation by SIRT2 plays a central role in platelet function. The effects of SIRT2 are mediated in part by the acetylation and inhibition of Akt. These results open a new avenue for research into the control of platelet function, and may help to identify new therapeutic targets. |
### Instruction:
Are escherichia coli isolates from patients with bacteremic urinary tract infection genetically distinct from those derived from sepsis following prostate transrectal biopsy?
### Response:
| Our finding supports the hypothesis that E. coli causing PPBS derive directly from the rectum, bypassing the urinary tract, and therefore do not require many of the virulence capabilities necessary for an E. coli strain that must persist in the urinary tract. In light of the increasing prevalence of highly resistant E. coli strains, a new approach for prevention of PPBS is urgently required. |
### Instruction:
Do exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine-induced apoptosis?
### Response:
| Our results suggest that exosomes derived from SHEDs are considered as new potential therapeutic tool in the treatment of Parkinson's disease. |
### Instruction:
Do virologically suppressed patients with asymptomatic and symptomatic HIV-associated neurocognitive disorders display the same pattern of immune activation?
### Response:
| Aviraemic patients with sHAND did not display the same pattern of immune activation as subjects with ANI, suggesting that the underlying pathophysiological mechanisms could be different. |
### Instruction:
Is oxidative DNA damage involved in cigarette smoke-induced lung injury in rats?
### Response:
| These findings indicate that long-term exposure to cigarette smoker increases ROS levels, decreases total antioxidant capacity, and interferes DNA repair capacity that eventually induces oxidative DNA damage, which appears to play an important role in cigarette smoke-induced lung injury in rats, and determination of 8-OHdG levels might be a useful method for monitoring oxidative damage in cigarette smokers. |
### Instruction:
Is aLCAM a Novel Cytoplasmic Membrane Protein in TNF-α Stimulated Invasive Cholangiocarcinoma Cells?
### Response:
| This study indicated that ALCAM may be a novel protein candidate expressed on cytoplasmic membranes of invasive CCA cells that could be used as a biomarker for development of diagnosis, prognosis, and drug or antibody-based targeted therapies in the future. |
### Instruction:
Is intrathoracic anastomotic leakage after gastroesophageal cancer resection associated with increased risk of recurrence?
### Response:
| Intrathoracic anastomotic leakage increased the risk of recurrence in patients who underwent curative gastroesophageal cancer resection. |
### Instruction:
Do microvascular free tissue transfer in acute and secondary burn reconstruction?
### Response:
| Free tissue transfer has a small but definite role within acute and secondary burn reconstruction surgery. Despite the complexity of the burn defects involved, free flaps appear to have a high success rate within this cohort of patients. This appears to be the case as long as the appropriate patient and flap is selected, care is taken to debride all devitalised tissue and due diligence paid to the vascular anastomosis by performing it away from the zone of injury. |
### Instruction:
Is high DHEAS/free testosterone ratio related to better metabolic parameters in women with PCOS?
### Response:
| High DHEAS/FT ratios are related to a better metabolic phenotype in women with PCOS and low levels can be used to detect women with PCOS that have a higher risk of metabolic problems. |
### Instruction:
Does pHLPP2 Downregulation contribute to Lung Carcinogenesis Following B [ a ] P/B [ a ] PDE Exposure?
### Response:
| Our studies not only first time identify PHLPP2 downregulation by lung carcinogen B[a]P/B[a]PDE, but also elucidate a novel molecular mechanisms underlying lung inflammation and carcinogenesis upon B[a]P/B[a]PDE exposure. |
### Instruction:
Does pharmacologic Inhibition of JAK1/JAK2 Signaling reduce Experimental Murine Acute GVHD While Preserving GVT Effects?
### Response:
| These data provide further evidence that JAK inhibition represents a new and potentially clinically relevant approach to GVHD prevention. |
### Instruction:
Are vegetable dishes , dairy products and fruits key items mediating adequate dietary intake for Japanese adults with spinal cord injury?
### Response:
| This study finds that vegetable dishes, dairy products and fruits are the key items mediating adequate dietary intake. Dietary guidelines promoting the intake of these dishes for SCI individuals are needed. |
### Instruction:
Is radiotherapy Alone Associated with Improved Outcomes Over Surgery in the Management of Solitary Plasmacytoma?
### Response:
| Radiotherapy alone can be considered as a more effective treatment for SP over surgery. Whether a combination of radiotherapy and surgery improves outcomes requires further study. |
### Instruction:
Is increases in physical activity as important as smoking cessation for reduction in total mortality in elderly men : 12 years of follow-up of the Oslo II study?
### Response:
| Even at the age of 73 years, PA is associated highly with mortality between groups of sedentary and active persons. Allowing for competing risk did not weaken these associations markedly. Public health strategies in elderly men should include efforts to increase PA in line with efforts to reduce smoking behaviour. |
### Instruction:
Does systems Genetics Analysis of Genome-Wide Association Study reveal Novel Associations Between Key Biological Processes and Coronary Artery Disease?
### Response:
| These findings provide novel insights into how genetic variation, interpreted in the context of biological processes and functional interactions among genes, may help define the genetic architecture of CAD. |
### Instruction:
Does microRNA-19a regulate lipopolysaccharide-induced endothelial cell apoptosis through modulation of apoptosis signal-regulating kinase 1 expression?
### Response:
| MiR-19a regulates ASK1 expression by targeting specific binding sites in the 3' untranslated region of ASK1 mRNA. Overexpression of miR-19a is an effective method to protect against LPS-induced apoptosis of endothelial cells. |
### Instruction:
Do imidazoline receptor antagonists idazoxan and efaroxan enhance locomotor functions in rats?
### Response:
| In our experimental conditions we demonstrated the ability of imidazoline receptor antagonists idazoxan and efaroxan to improve fatigue resistance during forced running in rats. |
### Instruction:
Is metabolic syndrome associated with better prognosis in patients with tongue squamous cell carcinoma?
### Response:
| MS is associated with early N category in TSCC. It is an independent prognostic factor for better survival in patients with TSCC. |
### Instruction:
Does tourniquet use during ankle surgery lead to increased postoperative opioid use?
### Response:
| We found an increase in postoperative opioid consumption correlated to tourniquet use. Possible preventive measures with antioxidant treatment to prevent ischemia/reperfusion injury should be investigated. |
### Instruction:
Does mfn2 affect Embryo Development via Mitochondrial Dysfunction and Apoptosis?
### Response:
| Low in vitro expression of Mfn2 attenuates the blastocyst formation rate and cleavage speed in mouse zygotes and causes mitochondrial dysfunction, as confirmed by the ATP and mtDNA levels and mitochondrial membrane potential. Mfn2 deficiency induced apoptosis through the Bcl-2/Bax and Ca(2+) pathways. These findings indicate that Mfn2 could affect preimplantation embryo development through mitochondrial function and cellular apoptosis. |
### Instruction:
Is the chemokine CXCL13 elevated in the cerebrospinal fluid of patients with neurosyphilis?
### Response:
| CXCL13 levels in the CSF of patients with neurosyphilis can be as high as in patients with LNB, exceeding the proposed threshold of 250 pg/mL for the diagnosis of LNB. Patients with encephalitic/myelitic syndromes appear to have especially high levels of CXCL13. Clinicians should be aware that high levels of CXCL13 are not found exclusively in LNB but also in other infectious diseases of the CNS. |
### Instruction:
Are wA29 '' we all one '' compassionate cities `` a global community joined for care ''?
### Response:
| This model supports people to become the real co-producers of services, as they know which services best respond to their needs. |
### Instruction:
Does hesperetin induce the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by Increasing Reactive Oxygen Species?
### Response:
| Our study suggests that hesperetin could inhibit the proliferation and induce the apoptosis of gastric cancer cells via activating the mitochondrial pathway by increasing the ROS. |
### Instruction:
Do high prevalence of CDH23 mutations in patients with congenital high-frequency sporadic or recessively inherited hearing loss?
### Response:
| These results revealed that CDH23 mutations are highly prevalent in patients with congenital high-frequency sporadic or recessively inherited hearing loss and that the mutation spectrum was diverse, indicating that patients with these clinical features merit genetic analysis. |
### Instruction:
Do hair concentrations of antiretrovirals predict viral suppression in HIV-infected pregnant and breastfeeding Ugandan women?
### Response:
| Antiretroviral hair concentrations represent an innovative tool that strongly predicts viral suppression among HIV-infected childbearing women during the critical periods of delivery and breastfeeding. |
### Instruction:
Does a default normal chest CT structured reporting field for coronary calcifications cause excessive false-negative reporting?
### Response:
| Implementing a structured reporting template improves reporting accuracy of coronary calcifications. |
### Instruction:
Do mR imaging findings of ovarian torsion correlate with pathological hemorrhagic infarction?
### Response:
| Pathological hemorrhagic infarction of ovarian torsion was associated with several MR imaging findings, including high signal intensity on T1WI/DWI, and irregular wall thickening on T2WI. |
### Instruction:
Does central pulse pressure predict BP reduction after renal denervation in patients with treatment-resistant hypertension?
### Response:
| Our data suggest that cPP, indicative of the degree of large arterial stiffening, may be helpful to identify responders to RDN. |
### Instruction:
Does hIV-1 Infection accelerate Age According to the Epigenetic Clock?
### Response:
| Overall, our results demonstrate that the epigenetic clock is a useful biomarker for detecting accelerated aging effects due to HIV infection. This tool can be used to accurately determine the extent of age acceleration in individual tissues and cells. |
### Instruction:
Does estetrol prevent and suppresses mammary tumors induced by DMBA in a rat model?
### Response:
| The natural fetal estrogen E4 prevents tumor initiation by DMBA and inhibits the growth of existing DMBA-induced tumors. |
### Instruction:
Is thymic stromal lymphopoietin activation of basophils in patients with allergic asthma IL-3 dependent?
### Response:
| Our findings indicate that basophil activation during early- and late-phase responses to inhaled allergen might be driven at least in part by TSLP. |
### Instruction:
Does prostaglandin E2 inhibit mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor?
### Response:
| The pharmacology of PGE2 in isolated human small airways was different from its profile in animal models. This first demonstration of powerful EP2 receptor-mediated inhibition of IgE-dependent contractions in human airways introduces a new selective target for the treatment of asthma. This EP2 control of mast cell-mediated bronchoconstriction is presumably exaggerated in patients with aspirin-exacerbated respiratory disease. |
### Instruction:
Do skin dendritic cells induce follicular helper T cells and protective humoral immune responses?
### Response:
| These data demonstrate that a major unappreciated function of skin DCs is their promotion of TFH cells and humoral immune responses that potentially represent an efficient approach for vaccination. |
### Instruction:
Does the Selective Sirtuin 1 Activator SRT2104 reduce Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans?
### Response:
| This is the first human study to demonstrate biological anti-inflammatory and anticoagulant responses consistent with the activation of sirtuin 1 by a small molecule. |
### Instruction:
Does ultrasound-mediated microbubble destruction enhance the therapeutic effect of intracoronary transplantation of bone marrow stem cells on myocardial infarction?
### Response:
| Ultrasound-mediated microbubble destruction increases the homing of BMSCs in the target area following intracoronary transplantation, which allows more BMSCs to differentiate into functional cardiomyocytes, thereby reducing myocardial infarct size and improving cardiac function. |
### Instruction:
Do human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation?
### Response:
| Expression of human K8 variants G62C, R341H, or R341C in mice predisposes to acute APAP hepatotoxicity, thereby providing direct evidence for the importance of these variants in human acute liver failure. |
### Instruction:
Does implementation of a standardized postanesthesia care handoff increase information transfer without increasing handoff duration?
### Response:
| A standardized, team-based approach to OR-to-PACU handoffs increased the quantity of patient information transferred, increased PACU nurse satisfaction, and did not increase the handoff duration. |
### Instruction:
Does cellular immunotherapy as maintenance therapy prolong the survival of the patients with small cell lung cancer?
### Response:
| CIT maintenance therapy in SCLC prolonged survival with only minimal side effects. Integrating CIT into current treatment may be a novel strategy for SCLC therapy, although further multi-center randomized studies are needed. |
### Instruction:
Does family accommodation mediate the association between anxiety symptoms in mothers and children?
### Response:
| These results inform theory and imply that the development of interventions designed to target family accommodation may improve the prognosis of those diagnosed with paediatric anxiety disorders and youth with subclinical anxiety symptoms by reducing both parent and child anxiety. |
### Instruction:
Is antigen-induced airway hyperresponsiveness and obstruction related to caveolin-1 expression in airway smooth muscle in a guinea pig asthma model?
### Response:
| Our data suggest that caveolin-1 expression in ASM has a crucial role in the development of antigen-induced airway obstruction and hyperresponsiveness in a guinea pig asthma model. In addition, the asthma model in guinea pigs appears to induce a contractile smooth muscle phenotype in the airways and a proliferative smooth muscle phenotype in pulmonary vessels. |
### Instruction:
Does low-cost workflow improvement reduce gastrointestinal block use 17 % by altering classic histotechnology testing?
### Response:
| This simple, low-cost, low-effort process change yielded immediate and significant time savings for grossing and histology staff, increased job satisfaction, and challenges conventional histotechnology teaching. |
### Instruction:
Do flow cytometric identification of immunophenotypically aberrant T-cell clusters on skin shave biopsy specimens from patients with mycosis fungoides?
### Response:
| FC is capable of identifying putative neoplastic cells on SSB specimens from patients with MF. Bright homogeneous CD26 expression is a common and previously undescribed immunophenotypic aberrancy on MF skin infiltrates. |
### Instruction:
Is a specific KRAS codon 13 mutation an independent predictor for colorectal cancer metachronous distant metastases?
### Response:
| There were significant clinical and molecular differences between synchronous and metachronous metastases. As an independent predictor, KRAS codon 13 mutation might be the key to explain the mechanism of colorectal cancer metachronous distant metastases. Together with clinical characteristics, it could aid in the early detection of metachronous metastases. |
### Instruction:
Is a Long Non-coding RNA Activated by Transforming Growth Factor-β an Independent Prognostic Marker of Gastric Cancer?
### Response:
| LncRNA-ATB plays an important role in EMT to promote invasion and metastasis through the TGF-β/miR-200s/ZEB axis, resulting in a poor prognosis in GC. LncRNA-ATB is a novel biomarker of lncRNA, indicative of a poor prognosis in GC patients. |
### Instruction:
Is lymphatic Invasion an Independent Adverse Prognostic Factor in Patients with Colorectal Liver Metastasis?
### Response:
| Intrahepatic lymphatic invasion, especially in combination with vascular invasion, is an important adverse prognostic factor for overall survival in patients with solitary CRLM after liver resection. |
### Instruction:
Does african flora have the potential to fight multidrug resistance of cancer?
### Response:
| African flora represents an enormous resource for novel cytotoxic compounds. To unravel the full potential, efforts should be strengthened throughout the continent, to meet the challenge of a successful fight against MDR cancers. |
### Instruction:
Does constipation prophylaxis reduce length of stay in elderly hospitalized heart failure patients with home laxative use?
### Response:
| Among elderly patients admitted for CHF exacerbations, failure to use constipation prophylaxis in patients with home laxative use is associated with a significantly longer LOS. Our data suggest that routine use of bowel prophylaxis for elderly CHF patients with preexisting constipation may reduce LOS. |
### Instruction:
Does gli1 promote transforming growth factor-beta1- and epidermal growth factor-induced epithelial to mesenchymal transition in pancreatic cancer cells?
### Response:
| Gli1 silencing alone has no effect on EMT initiation; however, it exerts a protumor role in the aggressive invasion of PC cells by promoting TGFβ1- and EGF-induced EMT. |
### Instruction:
Is existential security a necessary condition for continued breastfeeding despite severe initial difficulties : a lifeworld hermeneutical study?
### Response:
| Existential security in the breastfeeding relationship seems to be an underlying factor for confidence and therefore a necessary condition for continued breastfeeding when having severe initial breastfeeding difficulties. Unresolved feelings of insecurity may be a serious barrier to further breastfeeding that can result in a fear of breastfeeding. Such fear can force the mother to cease breastfeeding. This study highlights how women are situated in a complex cultural and biological context of breastfeeding that has existential consequences for them. An existential crisis forces mothers into a turning point for the breastfeeding decision. In the existential crisis, mothers' responsibility for the mother-infant relationship guides continuing or ceasing breastfeeding. |
### Instruction:
Does polymorphism at 19q13.41 Predicts breast Cancer Survival Specifically after Endocrine Therapy?
### Response:
| Our findings suggest carrying the rs8113308 rare allele may identify patients who will not benefit from adjuvant endocrine treatment. |
### Instruction:
Does insulin protect H9c2 rat cardiomyoblast cells against hydrogen peroxide-induced injury through upregulation of microRNA-210?
### Response:
| Insulin stimulated the expression of miR-210 through the PI3K/Akt pathway, resulting in a protective effect against cardiomyocyte injury that had been induced by H2O2/oxygen species. Our results provide novel evidence regarding the mechanism underlying the protective effect of insulin. |
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