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### Instruction:
Is translation of questionnaires measuring health related quality of life standardized : a literature based research study?
### Response:
| This study shows that there seems to be a consensus regarding the translation process (especially for internal validity) although most researchers did not use a translation guide. Moreover, we recommended that clinical researchers should consider three steps covering the process of translation, the qualitative validation as well as the quantitative validation. |
### Instruction:
Do secondary surgical management of suprachoroidal hemorrhage during pars plana vitrectomy?
### Response:
| Although suprachoroidal hemorrhage is one of most feared and devastating complications ofintraocular surgery, it might have relatively good prognosis with proper preoperative, intraoperative and postoperative management |
### Instruction:
Are small pulmonary artery defects reliable indicators of pulmonary embolism?
### Response:
| There is relatively poor interobserver agreement for subsegmental and/or small pulmonary artery defects, especially in CT pulmonary angiograms degraded by technical artifacts. These factors can lead to an increased frequency of inaccurate interpretation or indeterminate diagnosis of subsegmental and/or small defects. Caution is indicated in interpreting the significance of small vascular defects in CT pulmonary angiograms. |
### Instruction:
Is the uniform chest compression depth of 50 mm or greater recommended by current guidelines appropriate for all adults?
### Response:
| It is not appropriate that the current CC depth (≥50 mm), expressed only as absolute measurement without a fraction of the depth of the chest, is applied uniformly in all adults. In addition, in terms of safety and efficacy, simulated CC targeting approximately between one-third and one-fourth EAPD CC depth might be appropriate. |
### Instruction:
Does peanut oral immunotherapy transiently expand circulating Ara h 2-specific B cells with a homologous repertoire in unrelated subjects?
### Response:
| Using a novel affinity selection approach to identify antigen-specific B cells, we demonstrate that the early PNOIT-induced Ara h 2-specific B-cell receptor repertoire is oligoclonal and somatically hypermutated and shares similar clonal groups among unrelated subjects consistent with convergent selection. |
### Instruction:
Do the Influence of an undergraduate scientific initiation programme onn the professional profile of new physicians?
### Response:
| Apparently, taking part in a SIP led to lower income and worse civil servant recruitment exam results. However, this may only reflect a transient phase in a long-term process. New research currently under way will answer this remaining question, now that more time has elapsed since graduation. Rev Port Pneumol 2010; XVI (5): 797-808. |
### Instruction:
Does quality of the hematopoietic stem cell graft affect the clinical outcome of allogeneic stem cell transplantation?
### Response:
| Graft quality affects clinical outcome. Patients receiving grafts with inferior quality had more aGVHD and higher TRM. There is a need for better analyses for assessing graft quality in routine HSCT care; analysis using 7AAD on fresh PBSC grafts is not sufficient. |
### Instruction:
Does myocardial deformation imaging unmask subtle left ventricular systolic dysfunction in asymptomatic and treatment-naïve HIV patients?
### Response:
| HIV infection itself is accompanied by subclinical systolic dysfunction, not apparent to standard echocardiography that can be unmasked though using sensitive echocardiographic techniques. |
### Instruction:
Does acute High-Intensity Intermittent Aerobic Exercise reduce Plasma Angiopoietin-Like 2 in Patients With Coronary Artery Disease?
### Response:
| In patients with CAD, circulating ANGPTL2 levels are acutely reduced after HIIE and transiently increased after MICE. A sustained reduction in circulating ANGPTL2 levels could contribute to the chronic beneficial cardiometabolic effects of HIIE in patients with CAD. |
### Instruction:
Does infrapatellar fat pad preservation reduce wound complications after minimally invasive total knee arthroplasty?
### Response:
| Although IPFP preservation delayed operation time, it decreased wound complications after MIS TKA. These findings are important to consider when deciding whether or not to resect the IPFP. Whenever possible, IPFP preservation is probably the preferred technique to reduce wound complications. |
### Instruction:
Are pathologists able to differentiate reliably the lamina propria associated with Barrett 's musculofibrous anomaly from submucosa in oesophageal endoscopic resections?
### Response:
| With the application of usually easily recognizable criteria, pathologists are able to differentiate submucosa from lamina propria with musculofibrous anomaly in oesophageal ER specimens with a high degree of reproducibility. |
### Instruction:
Do high Maternal Serum Estradiol Levels Induce Dyslipidemia in Human Newborns via a Hepatic HMGCR Estrogen Response Element?
### Response:
| OS can induce a high maternal E2 environment, which up-regulates HMGCR expression in fetal hepatocytes via an ERE in the promoter, and induces elevated levels of TC and LDL-C in newborns that may be related to increased risk of metabolic disease in adulthood. |
### Instruction:
Is the cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats related to cell dose and infusion velocity?
### Response:
| Particularly cell dose but also infusion velocity contribute to complications encountered after intra-arterial cell transplantation. This should be considered before planning efficacy studies in rats and, potentially, in patients with stroke. |
### Instruction:
Do aquaporin-4 autoantibodies increase vasogenic edema formation and infarct size in a rat stroke model?
### Response:
| These results support the functional impact of NMO-antibodies and also offer an in-vivo-applicable animal model to investigate the properties of AQP4 in ischemic stroke. |
### Instruction:
Is post-translational modification of a chimeric EPO-Fc hormone more important than its molecular size in defining its in vivo hematopoietic activity?
### Response:
| The low content of tri- or tetra-antennary sialylated N-glycans linked to the chimeric EPO-Fc hormone, expressed in the goat mammary gland epithelial cells, defined its in vivo hematopoietic activity. |
### Instruction:
Are otic placode cell specification and proliferation regulated by Notch signaling in avian development?
### Response:
| Our results identify a novel function of Notch signaling in cell fate determination in the pre-otic field of avian embryos. |
### Instruction:
Does dihydromyricetin alleviate carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice?
### Response:
| These findings demonstrate that DHM alleviates CCl4-induced liver injury, suggesting that DHM is a promising candidate for reversing liver injury and ALF. |
### Instruction:
Are bar shoes and ambient temperature risk factors for exercise-induced pulmonary haemorrhage in Thoroughbred racehorses?
### Response:
| Ambient temperature is a risk factor for EIPH in Thoroughbred racehorses, with lower temperatures associated with increased risk. Bar shoes are a novel risk factor for EIPH in this population. |
### Instruction:
Is elevated serum periostin associated with liver stiffness and clinical outcome in biliary atresia?
### Response:
| Serum periostin was associated with liver stiffness in BA. Thus, serum periostin has potential as a parameter reflecting the severity in BA. |
### Instruction:
Does lactobacillus reuteri DSM 17938 shorten acute infectious diarrhea in a pediatric outpatient setting?
### Response:
| L. reuteri DSM 17938 is effective, safe, and well-tolerated in outpatient children with acute infectious diarrhea. |
### Instruction:
Is bilirubin independently associated with oxidized LDL levels in young obese patients?
### Response:
| Lower bilirubin levels may contribute to increased LDL oxidation in obese children and adolescents, predisposing to increased cardiovascular risk. |
### Instruction:
Does dNase I hypersensitivity analysis of the mouse brain and retina identify region-specific regulatory elements?
### Response:
| Overall, our results demonstrate the potential of genome-wide DNase I mapping to cis-regulatory questions regarding the regional diversity within the CNS. These data represent an extensive catalogue of potential cis-regulatory elements within the CNS that display region and temporal specificity, as well as a set of DHSs common to CNS tissues. Further examination of evolutionary conservation of DHSs between CNS regions and different species may reveal important cis-regulatory elements in the evolution of the mammalian CNS. |
### Instruction:
Do stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load?
### Response:
| SCR events overcome source-sink mismatch to trigger PVCs at a critical CaSR threshold. Above this threshold, PVCs emerge due to increased probability and reduced variability in timing of SCR events, leading to significant diastolic depolarization. Sites of lower electronic load, such as the PS, are preferential locations for triggering. |
### Instruction:
Do neonatal Pain and Infection Relate to Smaller Cerebellum in Very Preterm Children at School Age?
### Response:
| In very preterm children, exposure to painful procedures, as well as additional neonatal risk factors such as infection, were associated with reduced cerebellar volumes in specific subregions and poorer outcomes at school age. |
### Instruction:
Is constipation associated with diverticular disease - Analysis of 976 patients?
### Response:
| This large population based study revealed no association between colonic diverticular disease and constipation. Notably, the presence of diverticular disease significantly impacts quality of life. |
### Instruction:
Is the Artificial Urinary Sphincter Superior to a Secondary Transobturator Male Sling in Cases of a Primary Sling Failure?
### Response:
| In this cohort of patients with post-prostatectomy stress urinary incontinence and a failed primary sling those who underwent a secondary sling procedure were up to 6 times more likely to have persistent incontinence vs those who underwent artificial urinary sphincter placement. These data are useful for counseling patients and planning surgery. We currently recommend placement of an artificial urinary sphincter for patients in whom an initial sling has failed. |
### Instruction:
Does uroepithelial Thickening on Sonography improve Detection of Vesicoureteral Reflux in Children with First Febrile Urinary Tract Infection?
### Response:
| Uroepithelial thickening is associated with an increased risk of high grade vesicoureteral reflux and is an abnormal finding warranting voiding cystourethrography. Sensitivity of renal and bladder ultrasound as a screening test for high grade vesicoureteral reflux is markedly improved when uroepithelial thickening is considered. |
### Instruction:
Does divergence of transcriptional landscape occur early in B cell activation?
### Response:
| Upon examination of genome-wide transcription and regulatory elements, we conclude that the B cell commitment to different activation states occurs much earlier than previously thought and involves a multi-faceted receptor-specific transcriptional landscape. |
### Instruction:
Does receptor Tyrosine Kinase Expression predict Response to Sunitinib in Breast Cancer?
### Response:
| Triple-negative breast cancers overexpress RTKs but have decreased in vitro response to the TKI sunitinib. In addition to RET, TKIs that block EGFR may increase the therapeutic efficacy of TKIs in breast cancer. |
### Instruction:
Does a Novel Swine Model of Spontaneous Hypertension With Sympathetic Hyperactivity respond Well to Renal Denervation?
### Response:
| The Guizhou mini-pig is a novel spontaneous hypertensive animal model with sympathetic hyperactivity and responds well to RDN. |
### Instruction:
Are morphological changes of the peripheral nerves evaluated by high-resolution ultrasonography associated with the severity of diabetic neuropathy , but not corneal nerve fiber pathology in patients with type 2 diabetes?
### Response:
| The morphological changes in peripheral nerves of type 2 diabetic patients were found before the onset of neuropathy, and were closely correlated with the severity of diabetic neuropathy, but not with corneal C fiber pathology. |
### Instruction:
Does mechanical Tension promote the Osteogenic Differentiation of Rat Tendon-derived Stem Cells Through the Wnt5a/Wnt5b/JNK Signaling Pathway?
### Response:
| UMT induced the osteogenic differentiation of rTDSCs via the Wnt5a/Wnt5b/JNK signaling pathway. Accordingly, this pathway may influence the heterotopic ossification of tendon tissue subjected to excessive tension. |
### Instruction:
Does epicardial adipose tissue have a unique transcriptome modified in severe coronary artery disease?
### Response:
| The EAT transcriptome is unique when compared to SAT. In the setting of CAD versus valvulopathy, there is possible alteration of the EAT transcriptome with gene suppression. This pilot study explores the transcriptome of EAT in CAD and valvulopathy, providing new insight into its physiologic and pathophysiologic roles. |
### Instruction:
Is cafeteria diet-fed mice a pertinent model of obesity-induced organ damage : a potential role of inflammation?
### Response:
| Functional and structural damage in CAF were higher than HF of similar macronutrient composition. This study provides a novel dietary model in mice that mimics multi-organ physiologic alterations in humans secondary to obesity. |
### Instruction:
Does scatter Photocoagulation Reduce Macular Edema or Treatment Burden in Patients with Retinal Vein Occlusion : The RELATE Trial?
### Response:
| In patients with macular edema resulting from RVO, there was no short-term clinically significant benefit from monthly injections of 2.0-mg versus 0.5-mg ranibizumab injections and no long-term benefit in BCVA, resolution of edema, or number of ranibizumab injections obtained by addition of laser treatment to ranibizumab. |
### Instruction:
Does hyperbaric oxygen intervention reduce secondary spinal cord injury in rats via regulation of HMGB1/TLR4/NF-κB signaling pathway?
### Response:
| Hyperbaric oxygen reduced the expressions of HMGB1, TLR4, and NF-κB and reduced secondary SCI as measured using BBB scores. |
### Instruction:
Do identification of two metallothioneins as novel inhalative coffee allergens cof a 2 and cof a 3?
### Response:
| In addition to the previously described Cof a 1 we have identified two further coffee proteins to be type I coffee allergens (Cof a 2 and Cof a 3) which may have a relevant potential for the specific diagnosis and/or therapy of coffee allergy. |
### Instruction:
Does pulsatile GnRH be Superior to hCG in Therapeutic Efficacy in Adolescent Boys With Hypogonadotropic Hypogonadodism?
### Response:
| Boys with HH may be effectively treated with GnRH. We suggested that GnRH exhibits higher efficacy in treating adolescent boys with HH than hCG. |
### Instruction:
Is smoking associated with more abdominal fat in morbidly obese patients?
### Response:
| Positive associations between smoking and BMI, and waist circumference and percentage of body fat, were found among male morbidly obese patients, but not among females. To the best of our knowledge, this study is the first investigation of these aspects in morbidly obese subjects. We speculate that our findings may indicate that the coexistence of morbid obesity and smoking helps to explain the more serious medical conditions, particularly cardiovascular diseases and neoplasms, seen in these patients. |
### Instruction:
Are glenoid version and inclination risk factors for anterior shoulder dislocation?
### Response:
| The results of this study strongly suggest that glenoid version and inclination are significantly increased in patients with established anterior shoulder instability compared with a matched control group. |
### Instruction:
Do adverse childhood experiences influence development of pain during pregnancy?
### Response:
| Adverse childhood experiences were associated with higher pain intensities and larger pain distributions in late pregnancy, which are risk factors for transition to chronic pain postpartum. |
### Instruction:
Does tests of the Attachment and Clinical Issues Questionnaire as It apply to Alcohol Dependence?
### Response:
| The 2 studies using different populations and definitions of alcohol dependence converged on similar results. The ACIQ was found to be a robust battery for measuring attachment and clinical issues displayed by both patient populations and high school students only predicted to develop alcohol dependence. The results were further discussed in terms of how they move us toward Research Domain Criteria (RDoC) approaches to diagnosis and treatment, paying attention to important individual differences in attachments, and clinical issues. |
### Instruction:
Does hyperbaric oxygen therapy increase insulin sensitivity in overweight men with and without type 2 diabetes?
### Response:
| Peripheral insulin sensitivity was increased following HBOT in overweight or obese males with and without type 2 diabetes; this increase was maintained for at least 30 minutes post HBOT. Changes in inflammatory cytokines may partly explain this effect. |
### Instruction:
Are increased intraventricular pressures as harmful as the electrophysiological substrate of heart failure in favoring sustained reentry in the swine heart?
### Response:
| By magnifying DoR, decreasing CV, and shortening APD, increased IVP was as harmful as HF-ER in favoring the substrate for sustained reentry in this model. The AA milieu contributed to a much lesser extent. Thus, a stricter control of IVP might be postulated as a useful add-on antiarrhythmic strategy in HF. |
### Instruction:
Does chronic high fat diet induce cardiac hypertrophy and fibrosis in mice?
### Response:
| These results suggest that chronic HFD induces myocardial hypertrophy and fibrosis, which may be mediated by GSK-3β inhibition. |
### Instruction:
Do inflammation scores predict survival for hepatitis B virus-related hepatocellular carcinoma patients after transarterial chemoembolization?
### Response:
| The prognostic ability of GPS is superior to other inflammation scores for HCC patients undergoing TACE. Combining GPS and CLIP improved the prognostic power for OS. |
### Instruction:
Does pelitinib ( EKB-569 ) target the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer?
### Response:
| This study demonstrated a novel approach, exploiting drug resistance, to selectively kill cancer stem-like cells after hyperthermia. |
### Instruction:
Does sE-cadherin serve as a diagnostic and predictive parameter in prostate cancer patients?
### Response:
| sE-cadherin performed most favorably from a large panel of serum proteins in terms of diagnostic and predictive potential in curatively treatable PCa. sE-cadherin merits further investigation as a biomarker for PCa. |
### Instruction:
Are realistic changes in monounsaturated fatty acids and soluble fibers able to improve glucose metabolism?
### Response:
| Increases of MUFA and soluble fibers intakes promote benefits on glucose metabolism, independently of adiposity, during a realistic lifestyle intervention in at-risk individuals. Mechanisms mediating these processes may include mainly insulin sensitivity improvement. |
### Instruction:
Do type I interferon and T helper 17 cells co-exist and co-regulate disease pathogenesis in lupus patients?
### Response:
| Type I interferon and Th17 pathways co-exist and co-regulate the pathogenic processes in SLE. Additionally, these studies clearly identify IL-6 as a common link between IFN-I and Th17 pathways in SLE pathogenesis. |
### Instruction:
Do reduced UDP-glucose Levels Are Associated with P-glycoprotein Over-expression in L1210 Cells and Limit Glucosylceramide Synthase Activity?
### Response:
| These evidence indicates that the down-regulation of UDP-glucose contents in Pgp-positive L1210 cells is responsible for their collateral sensitivity to ceramide-induced apoptosis. |
### Instruction:
Does fecal virome analysis of three carnivores reveal a novel nodavirus and multiple gemycircularviruses?
### Response:
| Together these results underline that many novel viruses are yet to be discovered and that fecal associated viruses are not always related to disease. Our study expands the knowledge of viral species present in the gut, although the interpretation of the true host species of such novel viruses needs to be reviewed with great caution. |
### Instruction:
Does obesity Influence Outcomes in Hepatocellular Carcinoma Patients following Curative Hepatectomy?
### Response:
| Our propensity score-matched analysis strengthens the case that obesity does not adversely affect surgical outcomes of HCC patients undergoing curative hepatectomy. |
### Instruction:
Does carotid Arterial Hemodynamic in Ischemic Levkoaraiosis suggest Hypoperfusion Mechanism?
### Response:
| Lower blood flow and higher resistance of carotid arteries are consistent with the hypo-perfusion theory of ILA. Carotid ultrasound could have a diagnostic and prognostic role in ILA patients. |
### Instruction:
Is expression of metastasis-associated gene-1 associated with bone invasion and tumor stage in human pituitary adenomas?
### Response:
| MTA1 is associated with the aggressive nature of pituitary tumors and may be a potential therapeutic target in this tumor type. |
### Instruction:
Does lA sprout randomized controlled nutrition and gardening program reduces obesity and metabolic risk in Latino youth?
### Response:
| LA Sprouts was effective in reducing obesity and metabolic risk. |
### Instruction:
Is complete seizure freedom possible in patients with MTLE-HS after surgery in spite of extratemporal electro-clinical features?
### Response:
| This study demonstrated two clusters of the semiologic repertoire, and the most frequent EEG finding was lateralized and localized ictal activity, while other types of EEG patterns were also recorded. Although the presence of atypical findings may suggest a more extended or even extratemporal zone, the seizure-free outcome demonstrated that if the critical amount of tissue can be resected within the epileptogenic network, this may be sufficient for termination of seizures. |
### Instruction:
Does network analysis of differentially expressed genes reveal key genes in small cell lung cancer?
### Response:
| A range of DEGs were revealed in SCLC, which could enhance the understandings about the pathogenesis of this disease and provide potential molecular targets for diagnosis as well as treatment. |
### Instruction:
Does small nucleolar RNA 78 promote the tumorigenesis in non-small cell lung cancer?
### Response:
| Our study identified that SNORD78 may be a potential therapeutic target for NSCLC. |
### Instruction:
Does cCAAT/enhancer-binding protein δ ( C/EBPδ ) aggravate inflammation and bacterial dissemination during pneumococcal meningitis?
### Response:
| C/EBPδ in the brain drives the inflammatory response and contributes to bacterial dissemination during pneumococcal meningitis. C/EBPδ does, however, not affect clinical parameters of the disease and does not confer a survival benefit. |
### Instruction:
Do ascites and alpha-fetoprotein improve prognostic performance of Barcelona Clinic Liver Cancer staging?
### Response:
| Adding AFP and ascites to the BCLC staging classification can improve prognosis prediction for early and intermediate stages of hepatocellular carcinoma. |
### Instruction:
Does microRNA-133a improve the cardiac function and fibrosis through inhibiting Akt in heart failure rats?
### Response:
| These results demonstrated that miR-133a improves the cardiac function and fibrosis through inhibiting Akt in heart failure rats. |
### Instruction:
Does silencing of TRPC1 regulate store-operated calcium entry and proliferation in Huh7 hepatocellular carcinoma cells?
### Response:
| These results suggest that TRPC1 may take part both in regulation of store-operated Ca(2+) entry and proliferation of hepatocellular carcinoma cells. |
### Instruction:
Does opportunistic mammography screening provide effective detection rates in a limited resource healthcare system?
### Response:
| From the results, in a setting with resource constraints, targeted screening of high risk individuals will give a higher yield, and if more resources are available, population-based screening of women 50 and above is effective. Opportunistic mammographic screening is feasible and effective in a middle income country with performance indicators within international standards. Waiting until women are symptomatic will lead to more advanced cancers. |
### Instruction:
Is avoidance of polypharmacy and excessive blood pressure control associated with improved renal function in older patients?
### Response:
| Avoidance of polypharmacy was associated with an improvement in renal function. |
### Instruction:
Is metabolic syndrome in female migraine patients associated with medication overuse headache : a clinic-based study in China?
### Response:
| Our study may suggest that chronic migraine is associated with MetS, especially when it is comorbid with analgesic overuse. MOH may be the risk factor for MetS in female migraine patients and associated with abdominal obesity and hypertension. |
### Instruction:
Does single-molecule sequencing reveal the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus?
### Response:
| The genomic characteristics presented here emphasize the contribution of MGEs to the emergence of multidrug-resistant and highly virulent strains of community-associated MRSA. Antibiotic resistance was further augmented by chromosomal mutations and redundancy of resistance genes. The complete genome of DAR4145 provides a valuable resource for future investigations into the global dissemination and phylogeography of ST772-MRSA-V. |
### Instruction:
Is unreamed Intramedullary Nailing a better alternative than External Fixator for Gustilo grade IIIB Tibial Fractures based on a meta-analysis?
### Response:
| The existing evidence supports unreamed intramedullary nailing to be a better method for treating Gustilo grade IIIB tibial fractures, and this might aid in the management of this sever injury. |
### Instruction:
Do vaccine-induced Aβ-specific CD8+ T cells do not trigger autoimmune neuroinflammation in a murine model of Alzheimer 's disease?
### Response:
| Altogether, these results suggest that Aβ-specific CD8(+) T cells are not major contributors to meningoencephalitis in response to Aβ vaccination. |
### Instruction:
Does low expression of B-cell-associated protein 31 in human primary hepatocellular carcinoma correlate with poor prognosis?
### Response:
| BAP31 expression is an independent prognostic factor for OS of patients with postoperative HCC, and low expression levels of BAP31 in HCC may indicate poor outcomes of HCC patient after surgical resection. |
### Instruction:
Is body composition associated with multisite lower body musculoskeletal pain in a community-based study?
### Response:
| Greater fat mass and fat mass index were associated with a greater number of lower body pain sites, with no association observed for fat-free mass. Understanding the mechanism by which increased fat mass is associated with pain may provide important insights into therapeutic strategies for the prevention of pain. |
### Instruction:
Are dietary fatty acid intakes related to the risk of ulcerative colitis : a case-control study?
### Response:
| Our results showed that higher consumptions of total fats, oleic acid, SAFAs, total PUFAs, trans fat, MUFAs, and linoleic acid are significantly associated with increased risk for UC; however, no statistically significant associations were detected between the risk of disease and n-3 PUFAs and cholesterol intake. |
### Instruction:
Does the limited storage capacity of gonadal adipose tissue direct the development of metabolic disorders in male C57Bl/6J mice?
### Response:
| Marked inter-depot differences exist in WAT immune cell composition and expandability. The limited storage capacity of gWAT seems to direct the development of metabolic disorders in male C57Bl/6J mice. |
### Instruction:
Does carotid Artery Applanation Tonometry Cause Significant Baroreceptor Activation?
### Response:
| We conclude that in our study, carotid artery applanation tonometry as performed by an experienced researcher did not cause clinically significant baroreceptor activation. |
### Instruction:
Does resveratrol attenuate microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice?
### Response:
| RSV increases SIRT-1 expression in ob/ob septic mice to reduce microvascular inflammation and improves survival. |
### Instruction:
Is muscular dystrophy in the mdx mouse a severe myopathy compounded by hypotrophy , hypertrophy and hyperplasia?
### Response:
| The best-known consequence of lack of dystrophin that is common to DMD and the mdx mouse is the conspicuous necrosis and regeneration of muscle fibres. We present protocols for measuring this in terms both of loss of muscle nuclei previously labelled with BrdU and of the intensity of myonuclear labelling with BrdU administered during the regeneration period. Both measurements can be used to assess the efficacy of putative antinecrotic agents. We also show that lack of dystrophin is associated with a number of previously unsuspected abnormalities of muscle fibre structure and function that do not appear to be directly associated with myonecrosis. |
### Instruction:
Do exosome-like Extracellular Vesicles from MYCN-amplified Neuroblastoma Cells Contain Oncogenic miRNAs?
### Response:
| MYCN-amplified neuroblastoma cell lines secrete exosome-like particles containing oncogenic miRNAs. This work showed for the first time that neuroblastoma cells secrete exosome-like particles containing miRNAs with potential roles in cancer progression. These findings indicate a new way for MYCN-amplified neuroblastoma cells to interact with the tumor environment. |
### Instruction:
Are femoral diameter and stem type independent risk factors for ARMD in the large-headed ASR THR group?
### Response:
| Stem type and increasing femoral size as independent risk factors for ARMD in the cohort of ASR XL THR patients, support the importance of taper failure in the development of ARMD. The present results suggest that the degree of taper failure may be variable and dependent on the taper design. |
### Instruction:
Do different types of antagonists modify the outcome of complete denture renewal?
### Response:
| Denture renewal improves masticatory function. The complete denture group benefited least from renewal; the dentate group benefited most. This study confirmed the usefulness of denture renewal for improving functions and oral health- related quality of life. |
### Instruction:
Does streptococcus pneumoniae trigger progression of pulmonary fibrosis through pneumolysin?
### Response:
| Our data unravel a novel mechanism by which infection with Spn through Ply release induces progression of established lung fibrosis, which can be attenuated by protein-based vaccination of mice. |
### Instruction:
Does parkinson bradykinesia correlate with EEG background frequency and perceptual forward projection?
### Response:
| The decreased flash-lag illusion and lower electroencephalography background frequency in more bradykinetic PD patients provides support for disturbed visuomotor anticipations, putatively caused by reduced, sub-cortically mediated, network efficiency. This suggests a link between anticipation in early-stage visual motion processing and motor preparation. |
### Instruction:
Do evaluation of diagnostic biomarkers for acute kidney injury in major burn patients?
### Response:
| LD, lactic acid and serum creatinine were acceptable as diagnostic biomarkers of AKI and LD, serum creatinine, AST, and serum myoglobin were reasonable as diagnostic biomarkers of early AKI. However, cystatin C was an unfavorable biomarker in major burn patients. |
### Instruction:
Does the Use of 123I in Diagnostic Radioactive Iodine scan in Children with Differentiated Thyroid Carcinoma?
### Response:
| (123)I is effective for use in diagnostic radioactive iodine scans in children with differentiated thyroid cancer. The primary advantages of using (123)I include decreased radiation exposure and avoidance of stunning. However, in children there is a possibility of missed detection of metastatic pulmonary disease. |
### Instruction:
Does oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorate cauda equina compression injury in rats?
### Response:
| The data indicate that cPLA2 activity plays a significant role in tissue injury and pain after LSS. Reducing the levels of proinflammatory and tissue damaging eicosanoids and the deleterious lipid mediator LPC shows therapeutic potential. ATK inhibits cPLA2 activity, thereby decreasing the levels of injurious lipid mediators, reducing pain, improving functional deficits, and conferring protection against LSS injury. Thus, it shows potential for preclinical evaluation in LSS. |
### Instruction:
Is nuclear Factor-Y an adipogenic factor that regulates leptin gene expression?
### Response:
| These studies advance our understanding of leptin gene expression and show that NF-Y controls the expression of leptin and other adipocyte genes and identifies a new form of lipodystrophy. |
### Instruction:
Are genetic variations in genes involved in testosterone metabolism associated with prostate cancer progression : A Spanish multicenter study?
### Response:
| SNPs in SRD5A1 seem to affect the clinical characteristics of Spanish patients with PCa. |
### Instruction:
Does comprehensive Analysis of Large Sets of Age-Related Physiological Indicators reveal Rapid Aging around the Age of 55 Years?
### Response:
| These findings provide evidence that the progression of physiological age is not linear with that of chronological age, and that periods of mild change in physiological age are separated by periods of more rapid aging. |
### Instruction:
Does a novel anti-microtubule agent with carbazole and benzohydrazide structures suppress tumor cell growth in vivo?
### Response:
| Taken together, these findings suggest that HND-007 is a promising lead compound for development of novel anti-mitotic, anti-microtubule chemotherapeutic agents. |
### Instruction:
Is salt tolerance evolutionarily labile in a diverse set of angiosperm families?
### Response:
| Our results suggest that the pattern of many independent gains of salt tolerance near the tips of the phylogeny is found in many angiosperm families. This suggests that the pattern reported in the grasses of high evolutionary lability may be a common feature of salt tolerance evolution in angiosperms. |
### Instruction:
Does serum hepcidin predict uremic accelerated atherosclerosis in chronic hemodialysis patients with diabetic nephropathy?
### Response:
| These findings suggest possible linkage between iron metabolism and hepcidin modulation abnormalities that may contribute to the development of UAAS in CHD/DN patients. |
### Instruction:
Are membranous expressions of Lewis y and CAM-DR-related markers independent factors of chemotherapy resistance and poor prognosis in epithelial ovarian cancer?
### Response:
| Membranous expression of Lewis y and CAM-DR-related markers including CD44, CD147, HE4, integrin α5, β1, αv and β3 are associated with the development of chemotherapy resistance. High expression of Lewis y antigen and CAM-DR-related markers including CD44, CD147, HE4, integrin α5 and β1 are independent markers for PFS and OS, in which Lewis y and HE4 are the most significant. |
### Instruction:
Does aging affect morphology but not stimulated secretion of saliva in rats?
### Response:
| These findings showed that varying changes were observed in the morphology of salivary glands of aging rats without impaired function. |
### Instruction:
Does patatin-Like Phospholipase Domain-Containing 3 I148M Variant be Associated with Liver Steatosis and Fat Distribution in Chronic Hepatitis B?
### Response:
| In our CHB patients, the PNPLA3 polymorphisms influenced the development of liver steatosis, but not fibrosis status. The association of PNPLA3 p.I148M with liver steatosis increased with the greater amount of abdominal fat, irrespective of BMI. |
### Instruction:
Does dynamic contrast-enhanced MR microscopy identify regions of therapeutic response in a preclinical model of colorectal adenocarcinoma?
### Response:
| Two regions with distinct kinetic parameters were identified based on the histogram of TTP. The effect of bevacizumab, as measured by a decrease in K(trans), was confined to one of these regions. High spatiotemporal resolution MR studies may contribute unique insights into the response of the tumor microenvironment to therapy. |
### Instruction:
Are c-reactive protein levels associated with cerebral small vessel-related lesions?
### Response:
| Higher levels of hs-CRP were associated with lacunar infarcts. Thus, inflammatory processes may be involved in the pathogenesis of small-vessel disease. |
### Instruction:
Is hyperuricaemia associated with renal damage independently of hypertension and intrarenal renin-angiotensin system activation , as well as their circadian rhythms?
### Response:
| These data suggest that hyperuricaemia is associated with renal damage, independently of hypertension and intrarenal RAS activation, as well as their circadian rhythms. |
### Instruction:
Does light Physical Activity be Associated with Quality of Life after Colorectal Cancer?
### Response:
| Self-reported LPA, besides MVPA, was beneficially associated with multiple HRQoL outcomes in colorectal cancer survivors, especially in women and survivors with multiple comorbidities. Prospective studies are warranted to establish whether LPA is a suitable target for personalized lifestyle interventions to improve the HRQoL of colorectal cancer survivors. |
### Instruction:
Does decline in CA19-9 during chemotherapy predict survival in four independent cohorts of patients with inoperable bile duct cancer?
### Response:
| CA19-9 response is a robust predictor of survival in patients with inoperable bile duct cancer in four independent data sets. |
### Instruction:
Do variants in the Mannose-binding Lectin Gene MBL2 Associate With Sepsis Susceptibility or Survival in a Large European Cohort?
### Response:
| In this large, well-defined cohort of immune competent adult patients, no associations between MBL2 genotype and sepsis susceptibility or outcome were identified. |
### Instruction:
Do coliform bacteria isolated from recreational lakes carry class 1 and class 2 integrons and virulence-associated genes?
### Response:
| Integron-bearing multidrug resistant coliform bacteria carrying virulence genes are present in waters of recreational lakes. |
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