question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Is low prevalence of depression and anxiety linked to statutory retirement ages rather than personal work exit : a national survey?
### Response:
| There is a discontinuity in the prevalence of depressive episode for both men and women, coinciding with statutory retirement ages. No studied risk factor reduced the associations between age group and disorders. This population scale recovery may provide a model for understanding non-genetic factors. |
### Instruction:
Is c-reactive protein a strong independent predictor of death in type 2 diabetes : association with multiple facets of the metabolic syndrome?
### Response:
| CRP seems to be a better predictor of death and cardiovascular events than traditional risk factors or parameters of metabolic control in type 2 diabetic patients at high risk for cardiovascular endpoints. Additionally, CRP is associated with several facets of the metabolic syndrome. |
### Instruction:
Does trp53 loss during in vitro selection contribute to acquired Ara-C resistance in acute myeloid leukemia?
### Response:
| These data indicate that Trp53 loss-of-function could partly explain the acquisition of AML chemoresistance, and suggest that PFTalpha could be useful in treatment of relapsed AML. |
### Instruction:
Is the anemia of `` haemoglobin-deficit '' ( hbd/hbd ) mice caused by a defect in transferrin cycling?
### Response:
| Our results indicate that heme biosynthesis, DMT1, and the mitochondrial iron handling machinery are all normal in hemoglobin-deficit mice, while transferrin cycling is deficient. Therefore, the product of Sec15l1 is directly involved in vesicular trafficking, docking, fusing, and/or cargo delivery in erythroid precursors. |
### Instruction:
Is directly administered antiretroviral therapy in methadone clinics associated with improved HIV treatment outcomes , compared with outcomes among concurrent comparison groups?
### Response:
| These results suggest that methadone clinic-based DAART has the potential to provide substantial clinical benefit for HIV-infected IDUs. |
### Instruction:
Does [ Retrospective analysis of colorectal carcinomas reveal potential for improvement of diagnostic quality ]?
### Response:
| Due to retrospective analysis of colorectal cancer specimens we were able to identify potential for improvement of diagnostic quality. Furthermore our data underline the importance of an oncological resection, if a high risk carcinoma has been detected within a polypectomy specimen. |
### Instruction:
Does a genetic dissection of the LlaJI restriction cassette reveal insights on a novel bacteriophage resistance system?
### Response:
| The hetero-subunit structure of LlaJI, wherein one subunit mediates DNA binding whilst the other subunit is predicted to catalyze strand hydrolysis distinguishes LlaJI from previously characterized restriction-modification systems. Furthermore, this distinction is accentuated by the fact that whilst LlaJI behaves as a conventional Type IIA system in vivo, in that it restricts un-methylated DNA, it resembles the Type IV McrBC endonuclease, an enzyme specific for methylated DNA. A number of similar restriction determinants were identified in the database and it is likely LlaJI together with these homologous systems, comprise a new subtype of the Type II class incorporating features of Type II and Type IV systems. |
### Instruction:
Is metabolomic database annotations via query of elemental compositions : mass accuracy insufficient even at less than 1 ppm?
### Response:
| More than 1.6 million molecular formulae in the range 0-500 Da were generated in an exhaustive manner under strict observation of mathematical and chemical rules. Assuming that ion species are fully resolved (either by chromatography or by high resolution mass spectrometry), we conclude that a mass spectrometer capable of 3 ppm mass accuracy and 2% error for isotopic abundance patterns outperforms mass spectrometers with less than 1 ppm mass accuracy or even hypothetical mass spectrometers with 0.1 ppm mass accuracy that do not include isotope information in the calculation of molecular formulae. |
### Instruction:
Do mucin genes have different expression patterns in healthy and diseased upper airway mucosa?
### Response:
| These results suggest that NP have a different pattern of mucin expression than healthy NM and that CF polyps (increased MUC5B) and AC polyps (decreased MUC2) have a different mucin expression pattern than bilateral NP. |
### Instruction:
Does validity of a prescription claim database to estimate medication adherence in older persons?
### Response:
| The high concordance between prescription claims database and pill counts suggested that the rate with which patients refill their medications usually is consistent with the rate they consume them. DPIN is not accurate for nondiscrete dosage forms or medications prescribed for "as-required" use. |
### Instruction:
Does fluoxetine modulate the circadian biological clock via phase advances of suprachiasmatic nucleus neuronal firing?
### Response:
| Actions of SSRIs at the level of the circadian biological clock add to the list of pharmacological effects for this drug class and encourage speculation as to their importance clinically. |
### Instruction:
Are plasma metastin levels negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome?
### Response:
| These results indicate that metastin is negatively associated with free androgen levels. The PCOS-associated insulin resistance and consequent hyperinsulinemia probably contribute to this effect by [1] stimulating androgen synthesis by the polycystic ovary (PCO) and [2] suppressing SHBG production in the liver. |
### Instruction:
Does genistein inhibit radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest?
### Response:
| A mechanism of increased cell death by genistein and radiation is proposed to occur via inhibition of NF-kappaB, leading to altered expression of regulatory cell cycle proteins such as cyclin B and/or p21WAF1/Cip1, thus promoting G2/M arrest and increased radiosensitivity. These findings support the important and novel strategy of combining genistein with radiation for the treatment of prostate cancer. |
### Instruction:
Does lack of p53 function promote radiation-induced mitotic catastrophe in mouse embryonic fibroblast cells?
### Response:
| These results are in line with studies reporting the role of p53 as a post-transcriptional regulator of cyclin B1 protein and confirm that dysregulation of cyclin B1 promote radiation-induced MC. These findings might be exploited to design strategies to augment the yield of MC in tumor cells that are resistant to radiation-induced apoptosis. |
### Instruction:
Does antisense oligonucleotides-induced local blockade of T-bet expression lead to airway inflammation in rats?
### Response:
| Antisense ODN-induced local blockade of T-bet expression leads to airway inflammation with a selective alteration in patterns of cytokine expression and recruitment of eosinophil cells similar to that in the OVA-sensitized animals. |
### Instruction:
Does heart failure elevate serum levels of cibenzoline in arrhythmic patients?
### Response:
| The selection of a cibenzoline dose based only on renal function may increase the risk of toxicity in patients with heart failure. Cardiac function should be taken into account in cibenzoline dosing. The log-BNP may be a useful index for predicting serum cibenzoline concentrations. |
### Instruction:
Is p-selectin expression , but not GPIIb/IIIa activation , enhanced in the inflammatory stage of Takayasu 's arteritis?
### Response:
| P-selectin expression, but not activated GPIIb/IIIa, is enhanced in ADP-activated platelets from patients in the inflammatory stage of TA. P-selectin may play a significant role in the inflammatory and thrombotic responses associated with intractable TA, presumably by inducing platelet-leukocyte interactions. |
### Instruction:
Is obesity the only independent factor associated with ultrasound-diagnosed non-alcoholic fatty liver disease : a cross-sectional case-control study?
### Response:
| Our data suggest that NAFLD diagnosed by ultrasound is associated with hypertriglyceridemia, impaired fasting glucose, silent myocardial ischemic pattern of ECG, obesity, and abnormal liver tests in adults. Among these factors, obesity was the only independent factor associated with ultrasound-diagnosed NAFLD. |
### Instruction:
Does subjective visual vertical perception relate to balance in acute stroke?
### Response:
| Verticality misperception was related to poor balance and might be an important element in the assessment of contributing factors to balance disorders after stroke. It should probably be taken into account when establishing balance rehabilitation programs for patients with hemiplegia. |
### Instruction:
Does treatment of mice with stem bark extract of Aphanamixis polystachya reduce radiation-induced chromosome damage?
### Response:
| Our study demonstrates that EAP protects mouse bone marrow cells against radiation-induced chromosomal aberrations and this reduction in radiation-induced chromosome damage may be due to free radical scavenging and reduction in lipid peroxidation. The radioprotection by EAP is best comparable to that of protection demonstrated by the grape fruit flavonone, naringin, in our earlier studies in mouse bone marrow cells. |
### Instruction:
Do the NK1.1+T cells alive in irradiated mice play an important role in a Th1/Th2 balance?
### Response:
| Our findings revealed that NK1.1+T cells that survive at an early stage after irradiation play an important role in the balance of the immune responses at a late stage after irradiation. |
### Instruction:
Do free fatty acids decrease circulating ghrelin concentrations in humans?
### Response:
| FFA exposure between 0 and 1 mmol/l significantly suppresses ghrelin levels independent of ambient GH and insulin levels. |
### Instruction:
Does aldosterone antagonism improve endothelial-dependent vasorelaxation in heart failure via upregulation of endothelial nitric oxide synthase production?
### Response:
| Spironolactone prevents the decrease in eNOS in the LV and aorta and improves NO-dependent vasorelaxation, suggesting that one potential mechanism of spironolactone is an improvement in vasoreactivity mediated though an increase in NO. |
### Instruction:
Is duration of hypotension before initiation of effective antimicrobial therapy the critical determinant of survival in human septic shock?
### Response:
| Effective antimicrobial administration within the first hour of documented hypotension was associated with increased survival to hospital discharge in adult patients with septic shock. Despite a progressive increase in mortality rate with increasing delays, only 50% of septic shock patients received effective antimicrobial therapy within 6 hrs of documented hypotension. |
### Instruction:
Do surfactant lung lavage using asymmetric high-frequency jet ventilation followed by conventional ventilation in rabbits with meconium aspiration?
### Response:
| Surfactant lung lavage by asymmetric HFJV followed by conventional ventilation is advantageous combination in rabbits with MAS and may be tested in neonatal MAS (Tab. 2, Fig. 2, Ref. 12). |
### Instruction:
Does dual inhibition of angiotensin converting enzyme and neutral endopeptidase produce effective blood pressure control in spontaneously hypertensive rats?
### Response:
| Two-week treatment with the dual ACE/NEP inhibitor omapatrilat caused a significant decrease of the SBP, inhibition of the serum ACE activity and increase of the plasma ANP values, and therefore it should be considered as a new potential therapeutic agent in blood pressure management (Tab. 3, Fig. 2, Ref. 20). |
### Instruction:
Is human degenerative valve disease associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation?
### Response:
| The mechanism of valvular heart disease involves an endochondral bone process that is expressed as cartilage in the mitral valves and bone in the aortic valves. Up-regulation of the Lrp5 pathway may play a role in the mechanism for valvular heart disease. |
### Instruction:
Does latent class analysis show strong heritability of the child behavior checklist-juvenile bipolar phenotype?
### Response:
| In a general population sample, LCA identifies a CBCL-JBD phenotype latent class that is associated with high rates of suicidality, is highly heritable, and speaks to the comorbidity between attention problems, aggressive behavior, and anxious/depression in children. |
### Instruction:
Does ketamine dose-dependently induce high-frequency oscillations in the nucleus accumbens in freely moving rats?
### Response:
| We propose that ketamine-induced abnormal increases in HFO form part of the complex neurological changes in this model of schizophrenia. Ketamine-induced increases in HFO, although sharing similar temporal dynamics to hyperactivity, may not be functionally related to increased movement. |
### Instruction:
Does cardiac imaging improve risk stratification in high-risk patients undergoing surgical revascularization?
### Response:
| In high-risk patients, the extension of scintigraphic myocardial scar has a significant impact on perioperative mortality. For similar values of ejection fraction at rest, additional imaging variables, such as echocardiographic end-diastolic diameter and wall motion score index, may contribute to select those patients in whom mortality may exceed 15%. |
### Instruction:
Is prenatal farm exposure related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children?
### Response:
| Maternal exposure to an environment rich in microbial compounds might protect against the development of atopic sensitization and lead to upregulation of receptors of the innate immune system. The underlying mechanisms potentially operating through the intrauterine milieu or epigenetic inheritance await further elucidation. |
### Instruction:
Does disc arthroplasty design influence intervertebral kinematics and facet forces?
### Response:
| The degree of constraint affects post-implantation kinematics and load transfer. With the Prodisc (3 DOF), the facets were partially unloaded, though the IAR did not match the fixed geometrical center of the UHMWPE. The latter observation suggests joint surface incongruence is developed during movement. With the Charité (5 DOF), the IAR was less variable, yet the facet forces tended to increase, particularly during lateral bending. These results highlight the important role the facets play in guiding movement, and that implant constraint influences facet/implant synergy. The long-term consequences of the differing kinematics on clinically important outcomes such as wear and facet arthritis have yet to be determined. |
### Instruction:
Is pDC-E3BP a dominant T-cell autoantigen in primary biliary cirrhosis?
### Response:
| Despite the presence of antibodies reactive with PDC-E3BP in the majority of PBC patients this self-protein is not a dominant T-cell autoantigen in PBC. |
### Instruction:
Does 5-year evaluation of electronic medical record flag alert for patients warranting secondary prevention of coronary heart disease?
### Response:
| These findings emphasize the need for regular evaluation of patients' lipid panels followed by appropriate therapy titration to reach LDL goals. Further study of factors influencing cholesterol management and methods to improve adherence is needed. |
### Instruction:
Are fresh blood and aged stored blood equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans?
### Response:
| Erythrocytes stored for 3 weeks are as efficacious as are erythrocytes stored for 3.5 h in reversing the neurocognitive deficit of acute anemia. Requiring fresh rather than stored erythrocytes for augmentation of oxygen delivery does not seem warranted. |
### Instruction:
Does mild hypercapnia increase subcutaneous and colonic oxygen tension in patients given 80 % inspired oxygen during abdominal surgery?
### Response:
| During supplemental oxygen administration, mild intraoperative hypercapnia increased tissue oxygen tension in the arm and colon. Previous work suggests that improved tissue oxygenation will reduce infection risk via the proposed pathomechanism, although only an outcome study can confirm this. |
### Instruction:
Is radiological review of specimen radiographs after breast localisation biopsy always necessary?
### Response:
| This study shows that a suitably trained or experienced surgeon can assess specimen radiographs effectively without the need for intraoperative radiological input although complete histological resection is not guaranteed despite specimen radiographs demonstrating clear margins. |
### Instruction:
Does mast cell degranulation alter lymphatic contractile activity through action of histamine?
### Response:
| In the in vitro mesenteric preparation, mast cell degranulation altered lymphatic contractile activity via the release of a mediator suggested to be histamine and the subsequent activation of H1 receptors. This action could potentially interfere with the expected ability of lymphatic vessels to reduce edema during inflammation. |
### Instruction:
Do perivascular cells along venules upregulate NG2 expression during microvascular remodeling?
### Response:
| The results suggest that NG2 proteoglycan expression is transiently upregulated along venules during microvascular remodeling, implicating NG2 as a marker of activated venules. |
### Instruction:
Does cyclophosphamide mobilization improve outcome in patients receiving stem cell transplantation for multiple myeloma?
### Response:
| We conclude that high-dose cyclophosphamide does not increase overall CR rates or improve TTP for patients with myeloma undergoing ASCT. |
### Instruction:
Is derangement of the E-cadherin/catenin complex involved in transformation of differentiated to anaplastic thyroid carcinoma?
### Response:
| This report shows that derangement of the E-cadherin/catenin complex is associated with the transformation of differentiated into anaplastic thyroid carcinoma. |
### Instruction:
Do triggers of sustained monomorphic ventricular tachycardia differ among patients with varying etiologies of left ventricular dysfunction?
### Response:
| VPBs initiated most sustained VT episodes. A significantly higher prematurity ratio was observed in the ischemic heart disease group. This may represent different mechanisms of VT initiation in patients with ischemic versus nonischemic heart disease. |
### Instruction:
Does azithromycin cure pityriasis rosea?
### Response:
| Azithromycin does not cure PR. |
### Instruction:
Does effect of ecoimmunonutrition support on maintenance of integrity of intestinal mucosal barrier in severe acute pancreatitis in dogs?
### Response:
| Our results suggested that EIN could maintain the integrity of intestinal mucosal barrier and reducing the incidence of bacterial translocation in SAP dogs. Early EIN was safe and more effective treatment for SAP dogs. |
### Instruction:
Does human herpesvirus 6 impair differentiation of monocytes to dendritic cells?
### Response:
| HHV-6 infection induces immunodeficiency via impaired differentiation of DCs. These results present a new concept for the pathogenesis of HHV-6-induced immunodeficiency. |
### Instruction:
Does footwear characteristics and risk of indoor and outdoor fall in older people?
### Response:
| Footwear characteristics were not significantly associated with falls either inside or outside the home. Risk of falling indoors was associated with going barefoot or wearing socks. Older people at risk of falling should therefore be advised to wear shoes indoors where possible. |
### Instruction:
Is childhood onset arthritis associated with an increased risk of fracture : a population based study using the General Practice Research Database?
### Response:
| Childhood onset arthritis is associated with a clinically significant increased risk of fracture in children, adolescents and, possibly, adults. Studies are urgently needed to characterise the determinants of structural bone abnormalities in childhood arthritis and devise prevention and treatment strategies. |
### Instruction:
Does pretreatment macrophage infiltration of the synovium predict the clinical effect of both radiation synovectomy and intra-articular glucocorticoids?
### Response:
| The observations support the view that intra-articular treatment either with 90Y and glucocorticoids or with glucocorticoids alone is especially successful in patients with marked synovial inflammation. |
### Instruction:
Does whitening effect of salicylic acid peel in Asian patients?
### Response:
| Salicylic acid peels are beneficial in whitening the face of Asian patients with acne. The whitening effect would be an important factor in choosing the superficial peeling agent for them. |
### Instruction:
Do successful treatment of earlobe keloids with imiquimod after tangential shave excision?
### Response:
| In this pilot study, imiquimod 5% cream following tangential shave excision was efficacious for the treatment of earlobe keloids. Further study is warranted to confirm the utility of imiquimod 5% cream in the treatment of earlobe keloids, as illustrated herein. |
### Instruction:
Does inhibition of Akt/PKB by a COX-2 inhibitor induce apoptosis in gastric cancer cells?
### Response:
| One of the pathways involved in SC-236-induced apoptosis in gastric cancer cells is through downregulation of Akt and then release of cytochrome c. |
### Instruction:
Do intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis?
### Response:
| The decrease in inflammation attributed to intraarticular corticosteroids is accompanied by down-modulation of bone destruction markers. These findings offer a rationale for the beneficial effect of corticosteroids on joint erosion in arthritis. |
### Instruction:
Is high anxiety associated with an increased risk of death in an older tri-ethnic population?
### Response:
| There is a high prevalence of anxiety in late life. Our results indicate an association between anxiety and increased risk of death in persons aged 75 and older. |
### Instruction:
Do acute stress and nicotine cues interact to unveil locomotor arousal and activity-dependent gene expression in the prefrontal cortex?
### Response:
| Stress interacts with nicotine-associated cues to uncover locomotor arousal, a state associated with prefrontal neuronal activation and immediate early gene expression. Thus, in nicotine-experienced individuals, stress may be an important determinant of subjective reactivity and prefrontal cortex activation that occurs in response to nicotine-associated cues. |
### Instruction:
Does the benzodiazepine alprazolam dissociate contextual fear from cued fear in humans as assessed by fear-potentiated startle?
### Response:
| Startle responses to an explicit threat cue and to an aversive context are psychopharmacologically distinct, suggesting that they may represent functionally dissociable aversive states. |
### Instruction:
Is reduced syndecan-1 expression correlated with the histological grade of malignancy at the deep invasive front in oral squamous cell carcinoma?
### Response:
| This study demonstrated that the reduced expression of syndecan-1 seems to be a useful marker of histological malignancy at the deep tumor invasive front and may be a useful prognostic factor in O-SCC. |
### Instruction:
Is an alternative spliced variant of circulating soluble tumor necrosis factor-alpha receptor-2 paradoxically associated with insulin action?
### Response:
| Native sTNFR2 and DS-TNFR2 show opposite associations with insulin action. DS-TNFR2 might play a role as a counterpart of the proinflammatory environment associated with insulin resistance. |
### Instruction:
Does a modular interface of IL-4 allow for scalable affinity without affecting specificity for the IL-4 receptor?
### Response:
| The modular architecture of the IL-4-IL-4Ralpha interface suggests a possible mechanism by which proteins might be able to generate binding affinity and specificity independently. So far, affinity and specificity are often considered to co-vary, i.e. high specificity requires high affinity and vice versa. Although the binding affinities of IL-4 and IL-13 to IL-4Ralpha differ by a factor of more than 1000, the specificity remains high because the receptor subunit IL-4Ralpha binds exclusively to IL-4 and IL-13. An interface formed by several interaction clusters/binding hot-spots allows for a broad range of affinities by selecting how many of these interaction clusters will contribute to the overall binding free energy. Understanding how proteins generate affinity and specificity is essential as more and more growth factor receptor families show promiscuous binding to their respective ligands. This limited specificity is, however, not accompanied by low binding affinities. |
### Instruction:
Is incidental acute prostatic inflammation associated with a lower percentage of free prostate-specific antigen than other benign conditions of the prostate : a prospective screening study?
### Response:
| In this prospectively screened cohort of men, there was a high incidence of asymptomatic inflammation on prostatic histology; f/tPSA values were significantly lower in men with acute inflammation. This might explain the variability of f/tPSA in improving specificity when used as a screening tool for prostate cancer, and might also reduce its effectiveness in differentiating tumours with more aggressive potential. |
### Instruction:
Does prophylactic hemodialysis prevent contrast-induced nephropathy after cardiac catheterization in patients with chronic renal insufficiency?
### Response:
| Prophylactic hemodialysis for CRI patients undergoing cardiac catheterization does not prevent CIN. |
### Instruction:
Does exercise training during hemodialysis improve dialysis efficacy and physical performance?
### Response:
| A low-intensity intradialytic exercise program is a viable adjunctive therapy, which improves HD efficacy and physical function in HD patients. |
### Instruction:
Is symptom change with exercise a temporary phenomenon for people with multiple sclerosis?
### Response:
| This small study found that when people with MS undertake exercise at a commencement level, they can expect that sensory symptoms may change temporarily, but they are unlikely to have any deleterious changes in fatigue and function. |
### Instruction:
Is robotic urological surgery in patients with prior abdominal operations associated with increased complications?
### Response:
| Our study demonstrates that robotic urological surgery can be performed in patients with prior abdominal surgery without increased perioperative complications. |
### Instruction:
Does noladin ether act on trabecular meshwork cannabinoid ( CB1 ) receptors to enhance aqueous humor outflow facility?
### Response:
| The results demonstrate for the first time that administration of noladin ether, an endocannabinoid agonist selective for the CB1 receptor, increases aqueous humor outflow facility. The data also show that noladin ether-induced enhancement of outflow facility is mediated through the trabecular meshwork CB1 receptor, with an involvement of p42/44 MAP kinase signaling pathway and changes in actin cytoskeletons. |
### Instruction:
Does cC-type chemokine receptor 5-Delta32 mutation protect against primary sclerosing cholangitis?
### Response:
| Because an intact CCR5 receptor is needed for internalization of specific pathogens and homing of memory T lymphocytes to the liver, we hypothesize that a deficient expression of this receptor resulting from the CCR5-Delta32 variant may protect against PSC. |
### Instruction:
Is hypercholesterolaemia associated with early atherosclerotic lesions in primary biliary cirrhosis?
### Response:
| Hypercholesterolaemia is not consistently associated with subclinical atherosclerosis in PBC, but should be treated if other risk factors for cardiovascular disease are also present. The search for factors that may protect patients with hypercholesterolaemic PBC against atherosclerosis should be encouraged. |
### Instruction:
Does levodopa availability improve with progression of Parkinson 's disease?
### Response:
| Levodopa availability improves with progression of PD. This may result from deteriorated peripheral activity of levodopa metabolising enzymes or an increasing enteric dysfunction with subsequent better duodenal levodopa absorption or both. |
### Instruction:
Is a common polymorphism in the complement factor H gene associated with increased risk of myocardial infarction : the Rotterdam Study?
### Response:
| Our data suggest that the CFH gene determines susceptibility to myocardial infarction. This finding underscores the importance of the alternative complement system in cardiovascular disease. |
### Instruction:
Does preoperative anal manometry predict continence after perineal proctectomy for rectal prolapse?
### Response:
| Perineal proctectomy provides relief from rectal prolapse, with good intermediate term results. Preoperative anal manometry can predict fecal continence rates after proctectomy, because patients with maximal squeeze pressures >60 mmHg have significantly improved outcomes. |
### Instruction:
Does routine tail suspension husbandry facilitate onset of seizure susceptibility in EL mice?
### Response:
| Although it was already known that repeated tail suspension could speed the onset of seizure susceptibility in EL mice, the present results are the first to demonstrate the converse finding that decreasing routine human handling can delay significantly the onset of seizure susceptibility. This suggests that removal of nonconsensual aspects of human-animal contact may delay or prevent the onset of seizure susceptibility. |
### Instruction:
Are igG-antiphospholipid antibodies in follicular fluid of IVF-ET patients related to low fertilization rate of their oocytes?
### Response:
| The presence of IgG aPL in FFs and increased infertility length were significantly related to lower fertilization rates, independently. Follicular fluid IgG aPL appears as a risk factor in association with successful IVF-ET outcomes. |
### Instruction:
Is weak expression of focal adhesion kinase ( pp125FAK ) in patients with cervical cancer associated with poor disease outcome?
### Response:
| Weak expression of FAK in invasive cervical cancer is a strong independent predictor of poor patient outcome. Further studies are warranted to elucidate whether FAK expression analysis is a suitable tool identifying patients at high risk even at an early clinical stage. |
### Instruction:
Is activin-A secretion increased in the eutopic endometrium from women with endometriosis?
### Response:
| The expression of inhibin/activin subunits in eutopic endometrium is altered in women with endometriosis, leading to higher levels of activin-A secretion by both glandular cells and stromal cells. |
### Instruction:
Does the PPAR-gamma activator rosiglitazone fail to lower plasma ACTH levels in patients with Nelson 's syndrome?
### Response:
| This study showed no effect of rosiglitazone treatment at maximum approved doses in lowering plasma ACTH levels in patients post bilateral adrenalectomy for Cushing's disease. |
### Instruction:
Are hyperhomocysteinemia and low B vitamin levels independently associated with venous thromboembolism : results from the EDITH study : a hospital-based case-control study?
### Response:
| The current data provides further knowledge in the complex relationship between hyperhomocysteinemia, low vitamin levels, and VTE. |
### Instruction:
Do passive leg movements and passive cycling alter arterial leg blood flow in subjects with spinal cord injury?
### Response:
| The results of the study demonstrate that passive leg movements and passive cycling do not alter the arterial peripheral circulation in subjects with SCI or control subjects. Although the results do not support the use of passive movements or exercise for the prevention of cardiovascular disease-related secondary complications, physical therapists should not be dissuaded from using these techniques to address musculoskeletal concerns. |
### Instruction:
Does [ Vitamin C decrease MMP-9 synthesis induced by hydrogen peroxide in an in vitro chorioamniotic membrane model ]?
### Response:
| Hydrogen peroxide induced the synthesis of metalloproteinase-9 in chorionic and chorioamniotic membranes. When chorionic and chorioamniotic membranes were cultured with vitamin C, 48 hours prior to peroxide hydrogen stimulus, the metalloproteinase-9 production diminished with statistical significance. |
### Instruction:
Does intrathecal baclofen therapy improve functional intelligibility of speech in cerebral palsy?
### Response:
| Intrathecal baclofen improved functional intelligibility of speech in a carefully selected subject. The Assessment of Intelligibility of Dysarthric Speech was found to be a useful quantitative tool to assess the effect of intrathecal baclofen on spastic dysarthria. |
### Instruction:
Does type of preexisting lipid therapy predict LDL-C response to ezetimibe?
### Response:
| Ezetimibe's LDL-C-lowering effects are most pronounced when added to preexisting combination lipid therapy. It appears to be more effective when added to statin therapy compared with other lipid-lowering therapies. |
### Instruction:
Does aCTH-cortisol activity during the 17beta-estradiol and LH preovulatory surge of the menstrual cycle?
### Response:
| Overall, these results suggest that the positive ACTH-Cortisol-Estrogen dependency, well documented in the female rat, is also operating at midcycle during the menstrual cycle in the human. |
### Instruction:
Does traditional risk factor assessment capture the extent of cardiovascular risk in systemic lupus erythematosus?
### Response:
| Impaired endothelial function as shown by decreased SAE, and an adverse profile of novel proatherogenic and prothrombotic vascular disease risk factors were prevalent in clinically quiescent SLE. These findings show the vulnerability of patients with SLE for atherosclerosis, and emphasize that assessments based on traditional risk factors alone may be inadequate. |
### Instruction:
Is intensive treatment of risk factors in patients with type-2 diabetes mellitus associated with improvement of endothelial function coupled with a reduction in the levels of plasma asymmetric dimethylarginine and endogenous inhibitor of nitric oxide synthase?
### Response:
| The intensive correction of hyperglycaemia is associated with the improvement of endothelial function, which is coupled with the decrease in the levels of reduction of plasma TNF-alpha and ADMA in patients with type-2 DM. A strict glycaemic control may exert anti-cytokine and anti-atherogenic effects and may therefore be pathophysiologically important. |
### Instruction:
Is hyaluronan molecular reflection by synovial lining concentration dependent and reduced in dilute effusions in a rabbit model?
### Response:
| Chain-chain interaction at >C* increases effective molecular domain size and hence HA reflection, promoting effective conservation of synovial fluid in normal joints. HA can fall below C* (approximately 1 mg/ml) in arthritic effusions, promoting loss of HA. The attendant failure of outflow buffering facilitates fluid escape and periarticular edema. |
### Instruction:
Is the alpha4bbeta7-integrin dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine?
### Response:
| Taken together, these results identify differential expression of the alpha4beta7-integrin on eosinophils and its critical role in regulating eosinophil responses in the intestine. |
### Instruction:
Are in contrast to specific B cells , human basophils unaffected by the toxic activity of an allergen toxin due to lack of internalization of immunoglobulin E-bound allergen?
### Response:
| According to our data, basophils are pure effector cells in the context of IgE-bound allergen and not involved in classical antigen presentation. |
### Instruction:
Does mMP-9 in serum correlate with the development of pulmonary complications in experimental acute pancreatitis?
### Response:
| MMP-9 in serum allows a valid grouping to severe and mild courses of experimental acute pancreatitis with a good predictive value for the development of pulmonary complications. MMP-9 should be evaluated as a valid single marker for the prediction of progression and the development of pulmonary complications in acute pancreatitis in clinical studies. |
### Instruction:
Is the MCP-1 -2518 A/G polymorphism a susceptibility factor for chronic pancreatitis?
### Response:
| Although the pro-inflammatory chemokine MCP-1 -2518 G allele is a severity factor for AP, it does not significantly alter susceptibility to CP. |
### Instruction:
Does use of modified multiband ligator facilitate circumferential EMR in Barrett 's esophagus ( with video )?
### Response:
| The novel technique of MBL-EMR described here facilitated and simplified circumferential removal of BE that contained HGIN and/or IMC. However, the method is associated with a very high stricture rate if circumferential EMR is performed in a single session. Complete removal of BE should be achieved by repeated partial EMR. Long-term follow-up is needed to observe for late recurrence and to determine the clinical impact of this method. |
### Instruction:
Is polymorphism in the tissue factor region associated with basal but not endotoxin-induced tissue factor-mRNA levels in leukocytes?
### Response:
| The TF-1208 polymorphism is functional in that it regulates basal TF-mRNA in circulating monocytes and circulating microparticle-associated TF-procoagulant activity in vivo, but does not influence the relative increase in TF-mRNA or coagulation activation during low-grade endotoxemia. |
### Instruction:
Is connective tissue growth factor responsible for transforming growth factor-beta-induced peritoneal mesothelial cell apoptosis?
### Response:
| Our results indicate that CTGF is an important downstream mediator of TGF-beta-induced PMC apoptosis. |
### Instruction:
Is proinflammatory cytokine-induced NF-kappaB activation in human mesangial cells mediated through intracellular calcium but not ROS : effects of silymarin?
### Response:
| Induction of NF-kappaB within 30 min by TNF-alpha- and IL-1beta was mediated through intracellular calcium but not ROS. Silymarin inhibited TNF-alpha-induced calcium-dependent NF-kappaB activation irrespective of its antioxidant effect. |
### Instruction:
Do immunohistochemical findings after LASIK confirm in vitro LASIK model?
### Response:
| Histologic findings in donor corneas with prior LASIK treatment confirm histologic observations in a recently introduced human organ culture LASIK model. This strengthens the reliability of the latter LASIK model for further studies concerning wound healing after LASIK surgery. |
### Instruction:
Does an insulin-like growth factor-I gene polymorphism modify the risk of microalbuminuria in subjects with an abnormal glucose tolerance?
### Response:
| In subjects with AGT, a higher risk for MA was observed in variant carriers than in carriers of the wild type genotype of this IGF-I gene polymorphism. Since MA is primarily associated with cardiovascular disease in subjects with AGT, our study suggests that variant carriers have a higher risk for cardiovascular disease than carriers of the wild type when they develop an AGT. |
### Instruction:
Does passive electrode effect reduce defibrillation threshold in bi-filament middle cardiac vein defibrillation?
### Response:
| A bystander electrode adjacent to a monofilament electrode in the MCV reduces DFT by 24% when compared with monofilament MCV alone. Microfilament electrodes decrease DFT as auxiliary anode but not as sole anode. |
### Instruction:
Does operon information improve gene expression estimation for cDNA microarrays?
### Response:
| By borrowing information about transcriptional activity of genes within classified operons, we improved the estimation of gene expression levels and the detection of differentially expressed genes. |
### Instruction:
Is subcutaneous adipose tissue cytokine production responsible for the restoration of systemic inflammation markers during weight loss?
### Response:
| A low-calorie diet is associated with an improvement in the systemic inflammatory status. This seems to be due to energy restriction rather than to adipose mass loss, since inflammatory levels return to baseline soon after weight stabilisation. Furthermore, a negative energy balance and fat mobilisation are associated with increased subcutaneous cytokine adipose expression. |
### Instruction:
Is n-chlorotaurine an effective antiviral agent against adenovirus in vitro and in the Ad5/NZW rabbit ocular model?
### Response:
| NCT demonstrated antiviral activity against adenovirus in vitro and in vivo. Further development of NCT as a topical antimicrobial is indicated. |
### Instruction:
Does intake of polyunsaturated fatty acids and vitamin E reduce the risk of developing amyotrophic lateral sclerosis?
### Response:
| A high intake of PUFAs and vitamin E is associated with a 50-60% decreased risk of developing ALS, and these nutrients appear to act synergistically. |
### Instruction:
Do the interleukin-6 gene -174G > C and -572G > C promoter polymorphisms are related to cerebral aneurysms?
### Response:
| This is the first study to show that IL-6 promoter polymorphisms are associated with intracranial aneurysmal disease. Whether this association is with the development, progression or rupture of such aneurysms, or represents survivor bias, is unclear. |
### Instruction:
Does cardiomyocyte-specific overexpression of NO synthase-3 protect against myocardial ischemia-reperfusion injury?
### Response:
| These results provide evidence that site-specific targeting of eNOS gene therapy may be more advantageous in limiting MI-R injury and subsequent cardiac dysfunction. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.