question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Are intrinsic racial differences in the risk of cesarean delivery explained by differences in caregivers or hospital site of delivery?
### Response:
| Hospital site of delivery and individual physician practices do not fully explain racial differences in the risk of primary cesarean delivery. |
### Instruction:
Is signaling via the type I IL-1 and TNF receptors necessary for bacterially induced preterm labor in a murine model?
### Response:
| The combination of IL-1 and TNF signaling plays a critical role in bacterially induced labor and myometrial COX-2 production in the mouse. Cervical gene expression patterns during bacterially induced preterm labor suggest fundamental differences from spontaneous term labor in the cervical ripening process. |
### Instruction:
Does change in cortical bone density and its distribution differ between boys and girls during puberty?
### Response:
| Our findings of sexual dimorphism in CoD development give support to the hypothesis that female bone deposits calcium for reproductive needs by consolidation of cortical bone during puberty. |
### Instruction:
Are interleukin-1 system gene polymorphisms associated with fat mass in young men?
### Response:
| The IL-1 system, recently shown to affect fat mass in experimental animals, contains gene polymorphisms that are associated with fat mass in young men. |
### Instruction:
Does treatment with the aromatase inhibitor letrozole during adolescence increase near-final height in boys with constitutional delay of puberty?
### Response:
| Our findings indicate that in adolescent boys an increase in adult height can be attained by use of aromatase inhibitors. |
### Instruction:
Are multiple thrombophilic gene mutations rather than specific gene mutations risk factors for recurrent miscarriage?
### Response:
| Inherited thrombophilias are associated with recurrent miscarriage. This association is manifest by total number of mutations rather than specific genes involved. |
### Instruction:
Do h. pylori genotypes and cytokine gene polymorphisms influence the development of gastric intestinal metaplasia in a Chinese population?
### Response:
| The carriage of proinflammatory IL-1B-511 and HP vacA m1 genotypes was associated with the development of gastric IM in the Chinese. |
### Instruction:
Does prenatal origin of childhood AML occur less frequently than in childhood ALL?
### Response:
| In the largest cohort examined so far we used identical approach for the backtracking of non-infant childhood ALL and AML. Our data suggest that either the prenatal origin of AML is less frequent or the load of pre-leukemic cells is significantly lower at birth in AML compared to ALL cases. |
### Instruction:
Are the molecular portraits of breast tumors conserved across microarray platforms?
### Response:
| This study validates the "breast tumor intrinsic" subtype classification as an objective means of tumor classification that should be translated into a clinical assay for further retrospective and prospective validation. In addition, our method of combining existing data sets can be used to robustly validate the potential clinical value of any new gene expression profile. |
### Instruction:
Does phospholipid composition control thromboplastin sensitivity to individual clotting factors?
### Response:
| Differing sensitivities of thromboplastin reagents to individual clotting factor levels have implications for monitoring of oral anticoagulant therapy and interpreting results of the PT assay. |
### Instruction:
Does smoking affect treatment outcome in patients with advanced nonsmall cell lung cancer?
### Response:
| Never-smokers were found to have an improved outcome over smokers when treated with chemotherapy. |
### Instruction:
Do renal function and 25-hydroxyvitamin D concentrations predict parathyroid hormone levels in renal transplant patients?
### Response:
| We conclude that 25OHD deficiency and insufficiency are common in renal transplant patients and may exacerbate secondary hyperparathyroidism. However, 25OHD, eGFR and phosphate only account for 19% of the variability in PTH levels. In addition, even a large increase in serum 25OHD levels is likely to result in only a small reduction in PTH. Therefore, alternative approaches to managing hyperparathyroidism in renal transplant recipients rather than supplementation with ergocalciferol are warranted. |
### Instruction:
Is transduction with a fiber-modified adenoviral vector superior to non-viral nucleofection for expressing tumor-associated Ag mucin-1 in human DC?
### Response:
| The use of the fiber-modified adenoviral vector presented here may therefore be favorable compared with non-viral gene delivery systems for DC that will be used in cancer immunotherapy. |
### Instruction:
Is [ Early ST resolution after successful primary PCI related to a favorable outcome in ST elevated AMI patients ]?
### Response:
| Early ST resolution post PCI represents improved myocardial perfusion and function and is related to a favorable clinical outcome in STEMI patients. |
### Instruction:
Are [ Heme oxygenase-1 and carbon monoxide key mediators for vascular smooth muscle cells proliferation induced by insulin-like growth factor-I ]?
### Response:
| Endogenous HO-1 and CO are important mediators for inhibiting IGF-I induced VSMCs proliferation by reducing VSMCs DNA synthesis and decelerating cell cycle progression. |
### Instruction:
Does vascular endothelial growth factor modulate matrix metalloproteinase-9 expression in asthma?
### Response:
| These results indicate that there is a close relationship between VEGF and MMP-9 expression and that inhibition of VEGF receptor down-regulates the expression of MMP-9. These findings suggest that VEGF signaling regulates MMP-9 expression and plays a critical role in initiation and maintenance of asthma. |
### Instruction:
Do products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery?
### Response:
| Abdominal surgery increases the synthesis of prostanoids, particularly via the COX-2 isoform. This compromises the ability of the duodenum to contract and to secrete HCO and to adjust luminal osmolality possibly via altered mucosal permeability. It is proposed that studies of gastrointestinal functions in animals subjected to abdominal surgery should include animals pre-treated with a COX-2 inhibitor. |
### Instruction:
Does gating of the expressed T-type Cav3.1 calcium channels is modulate by Ca2+?
### Response:
| Ca2+ ions facilitate transitions of Cav3.1 channel from open into closed and inactivated states as well as backwards transition from inactivated into closed state, possibly by interacting with its voltage sensor. |
### Instruction:
Is single dose of anti-D immune globulin at 75 microg/kg as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura in children?
### Response:
| A single 75 microg/kg dose of Anti-D raised the platelet count in children with newly diagnosed immune thrombocytopenic purpura more rapidly than standard-dose anti-D and as effectively as IVIg, with an acceptable safety profile. |
### Instruction:
Do plant stanols restore endothelial function in pre-pubertal children with familial hypercholesterolemia despite reduction of low-density lipoprotein cholesterol levels?
### Response:
| This study demonstrates that plant stanols reduce LDL-C levels in children with FH without improving endothelial function. |
### Instruction:
Does predictability of the target stimulus for sensory-guided movement modulate early somatosensory cortical potentials?
### Response:
| Sustained attention to task-relevant sensory stimuli differentially modulates areas within primary somatosensory cortex (S1) during a continuous sensory-motor transformation. |
### Instruction:
Does clotting factor concentrate given to prevent bleeding and bleeding-related complications in people with hemophilia A or B?
### Response:
| There is insufficient evidence from randomised controlled trials to determine whether prophylactic clotting factor concentrates decrease bleeding and bleeding-related complications in hemophilia A or B, compared to placebo, on-demand treatment, or prophylaxis based on pharmacokinetic data from individuals. Well-designed RCTs are needed to assess the effectiveness of prophylactic clotting factor concentrates. Two clinical trials are ongoing. |
### Instruction:
Is t ( 14 ; 18 ) ( q32 ; q21 ) involving IGH and MALT1 uncommon in cutaneous MALT lymphomas and primary cutaneous diffuse large B-cell lymphomas?
### Response:
| This study demonstrates that translocations involving MALT1, including IGH/MALT1, are uncommon in cutaneous MALT lymphomas and primary cutaneous DLBCL. Other translocations involving IGH also are not involved in the pathogenesis of at least most cutaneous MALT lymphomas. In contrast, primary cutaneous DLBCL may contain one of several IGH translocations in a minority of cases. |
### Instruction:
Is lIGHT ( TNFSF14 ) , a novel mediator of bone resorption , elevated in rheumatoid arthritis?
### Response:
| Our results indicate that LIGHT promotes RANKL-mediated osteoclastogenesis and that it can induce osteoclast formation by a mechanism independent of RANKL. The increased concentration of LIGHT in patients with RA raises the possibility that LIGHT may play a role in immunopathogenic conditions that are associated with localized or systemic bone loss. |
### Instruction:
Does chronic ethanol drinking reduce native T-type calcium current in the thalamus of nonhuman primates?
### Response:
| We conclude that chronic ethanol self-administration reduces calcium currents in thalamic relay cells without altering underlying current kinetics, which may provide a mechanistic framework for the well-documented disruptions in sleep/wake behavior in subjects with chronic ethanol exposure. |
### Instruction:
Is inhibition of basic leucine zipper transcription a major mediator of atrial dilatation?
### Response:
| Expression of basic leucine zipper transcription inhibitors is sufficient to results in atrial dilatation. This dilatation is acquired postnatally and is reversible. Thus, basic leucine zipper transcription inhibitors may be a relevant therapeutic target for preventing atrial dilatation and atrial fibrillation. |
### Instruction:
Does mRI feature after radiofrequency ablation of osteoid osteoma with cooled probes and impedance-control energy delivery?
### Response:
| MRI allows detection of temporal marrow signal change after radiofrequency ablation. The marrow signal change with a high-energy delivery protocol is larger than manual-control protocols. |
### Instruction:
Is xIAP related to the chemoresistance and inhibited its expression by RNA interference sensitize pancreatic carcinoma cells to chemotherapeutics?
### Response:
| XIAP is one of the most important factors in the pancreatic carcinoma chemoresistance, and inhibition of XIAP in pancreatic carcinoma can enhance the cancer sensitivity to chemotherapeutic drugs. |
### Instruction:
Do diets fail : the success of medical nutrition therapy in patients with diabetes?
### Response:
| The health-care team can provide practical and useful information to patients with diabetes that will improve management of their disease and enhance their well-being. |
### Instruction:
Does exercise training produce nonuniform increases in arteriolar density of rat soleus and gastrocnemius muscle?
### Response:
| Increases in blood flow capacity produced in Gr and Gw by ET appear to be due in part to increased arteriolar density. In contrast, increased arteriolar density does not contribute to increased blood flow capacity of Gw in IST rats. |
### Instruction:
Do astrocytes derived from glial-restricted precursors promote spinal cord repair?
### Response:
| Pre-differentiation of glial precursors into GDAs before transplantation into spinal cord injuries leads to significantly improved outcomes over precursor cell transplantation, providing both a novel strategy and a highly effective new cell type for repairing CNS injuries. |
### Instruction:
Is color vision but not visual attention altered in migraine?
### Response:
| The pattern of results indicates that there are no overall differences in search performance between migraine and control groups. The differences found for the S-cone colors are attributed to impaired discrimination of these colors in migraine and not to differences in attention. |
### Instruction:
Does chemotherapy regimen predict steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases?
### Response:
| Steatohepatitis is associated with an increased 90-day mortality after hepatic surgery. In patients with hepatic CRM, the chemotherapy regimen should be carefully considered because the risk of hepatotoxicity is significant. |
### Instruction:
Does hypertonic saline resuscitation prevent hydrostatically induced intestinal edema and ileus?
### Response:
| Hypertonic saline prevented intestinal tissue edema. In addition, hypertonic saline improved intestinal transit, possibly through more efficient transmission of muscle force through stiffer intestinal tissue. |
### Instruction:
Are commercial human albumin preparations for clinical use immunosuppressive in vitro?
### Response:
| DA-DKP was present in significant concentrations in all HSA sources tested and was partially responsible for the immunosuppressive effects of HSA on activated PBMCs and T-lymphocytes in vitro. In view of these findings, administering HSA to immunocompromised critically ill patients might be reevaluated. |
### Instruction:
Does hypertonic saline enhance host defense to bacterial challenge by augmenting Toll-like receptors?
### Response:
| Restoration of extracellular fluid in burn shock with hypertonic saline decreased thermal injury-induced bacterial translocation. Hypertonic saline increased the phagocytic activity and TLR2, TLR4, CXCR2, pp38, and P44/42 expression of peritoneal cells. Hypertonic saline decreased reactive oxygen species but increased TLR2, TLR4, and pp38 expression and phagocytic activity of bone marrow neutrophil. Stimulation of the TLRs with lipopolysaccharide in commensal depleted mice increased TLRs expression of neutrophil and decreased thermal injury-induced bacterial translocation. Taken together with the fact that stimulation of TLRs with hypertonic saline increases phagocytic activity of systemic inflammatory cells, we conclude that TLRs play a critical role in the innate immunity by recognizing bacteria and that hypertonic saline enhances host response to bacterial challenge by increasing TLRs of inflammatory cells. |
### Instruction:
Does engagement of PSGL-1 enhance beta ( 2 ) -integrin-involved adhesion of neutrophils to recombinant ICAM-1?
### Response:
| The PSGL-1-transduced signals can enhance beta(2)-integrin-involved adhesion of neutrophils to the recombinant ICAM-1, and this process depends on the dynamics of cytoskeleton. |
### Instruction:
Are aDAM33 polymorphisms associated with asthma susceptibility in a Japanese population?
### Response:
| Our results confirm the involvement of ADAM33 in the development of childhood asthma among the Japanese. |
### Instruction:
Does tumor necrosis factor-alpha contribute to below-level neuropathic pain after spinal cord injury?
### Response:
| These results suggest that expression of mTNF-alpha after injury is related to development of pain, and that reverse signaling through mTNF-alpha by sTNFR at that level reduces cellular markers of inflammatory response and pain-related behavior. |
### Instruction:
Does preoperative administration of intravenous flurbiprofen axetil reduce postoperative pain for spinal fusion surgery?
### Response:
| As compared with postoperative administration, preoperative administration of intravenous flurbiprofen axetil provides better postoperative analgesia and an opioid-sparing effect in patients undergoing spinal fusion surgery under general anesthesia. |
### Instruction:
Does the Mine Safety and Health Administration 's criterion threshold value policy increase miners ' risk of pneumoconiosis?
### Response:
| Citations for non-compliance with the respirable dust standard should be issued for any measure exposure that exceeds the exposure limit. |
### Instruction:
Are rates of delayed rebleeding from intracranial aneurysms low after surgical and endovascular treatment?
### Response:
| Rerupture of aneurysms treated by either coil embolization or surgical clipping is rare after the first year. Late retreatment is more common after coil embolization than after clipping but complication rates are low. Thus, late events are unlikely to overwhelm differences between procedures at 1-year follow-up. |
### Instruction:
Does impaired glucose tolerance increase stroke risk in nondiabetic patients with transient ischemic attack or minor ischemic stroke?
### Response:
| Impaired glucose tolerance is an independent risk factor for future stroke in nondiabetic patients with TIA or minor ischemic stroke. |
### Instruction:
Does rapamycin inhibit growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ?
### Response:
| In PyV-mT mouse mammary models, rapamycin inhibits the growth of premalignant lesions and invasive tumors. Although the inhibitory effect of rapamycin was striking, rapamycin treatment did not completely obliterate the lesions. |
### Instruction:
Does the bisphosphonate olpadronate inhibit skeletal prostate cancer progression in a green fluorescent protein nude mouse model?
### Response:
| The serum calcium, parathyroid hormone-related protein, and osteoprotegerin levels were significantly correlated with GFP area and X-ray scores. Treatment with olpadronate reduced tumor growth in the bone measured by GFP and X-ray imaging procedures. Imaging of GFP expression enables monitoring of tumor growth in the bone and the GFP results complement the X-ray assessment of bone disease. The data in this report suggest that olpadronate has potential as an effective inhibitor of the skeletal progression of clinical prostate cancer. |
### Instruction:
Are bone marrow-derived keratinocytes detected in normal skin and only rarely detected in wounded skin in two different murine models?
### Response:
| These results suggest that BMDCs do not significantly contribute to steady-state epidermal homeostasis and are not required or responsible for providing keratinocyte stem cells and keratinocyte repopulation following skin injury. |
### Instruction:
Is posttraumatic stress disorder screening status associated with increased VA medical and surgical utilization in women?
### Response:
| Female veterans who screen PTSD+ receive more VA medical/surgical services. Appropriateness of that care deserves further study. |
### Instruction:
Do [ Application of vital dye CFDA-SE and SNARF-1 to evaluate mixed lymphocyte reaction ]?
### Response:
| Our results show that application of vital dye CFDA-SE and SNARF-1, combined with flow cytometry is a powerful tool for evaluation of responsive intensity in one-way MLR. |
### Instruction:
Do [ Preparation and characterization of monoclonal antibody against Vibrio cholerae O139 ]?
### Response:
| The successful preparation of two anti-O139 mAbs provides a powerful tool for the development of a rapid method of detecting Vibrio cholerae O139 infection. |
### Instruction:
Does increased plasma fibrinogen predict one-year mortality in patients with acute ischemic stroke?
### Response:
| Increased concentration of plasma fibrinogen shortly after ischemic stroke independently increases risk of death within one year after stroke. |
### Instruction:
Is degenerative aortic valve stenosis , but not coronary disease , associated with shorter telomere length in the elderly?
### Response:
| In the elderly, calcific aortic stenosis, but not coronary disease, is associated with shorter leukocyte telomere length. |
### Instruction:
Does estrogen receptor beta protect the murine heart against left ventricular hypertrophy?
### Response:
| These findings demonstrate that E2, through ERbeta-mediated mechanisms, protects the murine heart against LVH. |
### Instruction:
Does local heat shock priming promote recanalization of thromboembolized microvasculature by upregulation of plasminogen activators?
### Response:
| Heat shock induces endogenous hyperfibrinolysis by upregulation of plasminogen activators that promote recanalization of thromboembolized microvasculature. |
### Instruction:
Does human paraoxonase-1 overexpression inhibit atherosclerosis in a mouse model of metabolic syndrome?
### Response:
| Our data suggest that in this mouse model of metabolic syndrome, expressing human PON1 inhibited the development of atherosclerosis, probably by reducing the amount of oxidized LDL in plasma and in the plaque, thereby preventing its proatherogenic effects. Adenovirus-mediated gene transfer of human PON1 may be a potential and useful tool to prevent/retard atherosclerosis in humans. |
### Instruction:
Does depressed heart rate response to vasodilator stress for myocardial SPECT predict mortality in patients after myocardial infarction?
### Response:
| HR response, readily attained during vasodilator stress myocardial perfusion studies, may provide useful additional prognostic information in post-MI patients. |
### Instruction:
Is brain natriuretic peptide a reliable indicator of ventilatory abnormalities during cardiopulmonary exercise test in heart failure patients?
### Response:
| In systolic HF, plasma BNP is related to an enhanced ventilatory response to exercise and offers a simple and reliable alternative to the cardiopulmonary exercise test in patients with inability or contraindications to exercise. |
### Instruction:
Do depression symptoms predict heart rate recovery after treadmill stress testing?
### Response:
| These findings confirm that depression is characterized by dysregulation of the ANS and implicate impaired exercise capacity as a potential mechanism. |
### Instruction:
Does nT-probrain natriuretic peptide predict complexity and severity of the coronary lesions in patients with non-ST-elevation acute coronary syndromes?
### Response:
| In this study of patients with NSTEACS, NT-proBNP levels progressively increase with the severity of CAD and degree of LV dysfunction. Increased levels of NT-proBNP independently predict the presence of more complex coronary lesions. |
### Instruction:
Is tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) an independent predictor of all-cause mortality , cardiac mortality , and myocardial infarction?
### Response:
| In a cohort of male patients undergoing coronary angiography, a single baseline determination of plasma TIMP-1 is independently predictive of the subsequent risk of death and MI. |
### Instruction:
Are alterations in intestinal contractility during inflammation caused by both smooth muscle damage and specific receptor-mediated mechanisms?
### Response:
| Alterations in intestinal smooth muscle function do not require the presence of the parasite and the absence of histopathological signs of inflammation do not warrant intact motor function. Changes in motor responses after T. spiralis infection are not only due to smooth muscle damage but also to disturbances in specific receptor-mediated mechanisms. |
### Instruction:
Does mitral annular calcification predict mortality and coronary artery disease in end stage renal disease?
### Response:
| MAC is associated with increased mortality and significant CAD in ESRD. These patients have increased LV cavity size, poorer LV systolic function, higher LV filling pressures compared to patients without MAC. |
### Instruction:
Does ethanol abrogate angiotensin II-stimulated vascular smooth muscle cell growth?
### Response:
| These results suggest that EtOH elicits a regulatory effect on the Ang II signaling pathway. |
### Instruction:
Do histological staining methods preparatory to laser capture microdissection significantly affect the integrity of the cellular RNA?
### Response:
| RNA damage can occur during the staining steps preparatory to laser capture microdissection, with the consequence of loss of representation of certain genes in microarray hybridization analysis. Inclusion of RNAase inhibitor in aqueous staining solutions appears to be important in protecting RNA from loss of gene transcripts. |
### Instruction:
Does macrophage metalloelastase accelerate the progression of atherosclerosis in transgenic rabbits?
### Response:
| Overexpression of MMP-12 causes accelerated atherosclerosis in Tg rabbits. These results suggest that macrophage-derived MMP-12 participates in the progression of atherosclerosis. |
### Instruction:
Does conditional expression of PTEN alter the androgen responsiveness of prostate cancer cells?
### Response:
| PTEN induction confers androgen independent CaP cells enhanced responsiveness to the anti-proliferative effects of anti-androgens and this action may involve non-AR mediated effects. |
### Instruction:
Does sCF modulate organ distribution and hematopoietic engraftment of CB-derived pluripotent HPC transplanted in NOD/SCID mice?
### Response:
| Our results indicate that stimulation with SCF modulates the tissue distribution of the progeny of the transplanted cells and improves the hematopoietic engraftment potential of transplanted CB cells. |
### Instruction:
Are urocortin 2 and urocortin 3 expressed by the human placenta , deciduas , and fetal membranes?
### Response:
| Gestational tissues differentially express UCN2 and UCN3 and, despite their homology to CRF, they did not stimulate placental ACTH secretion. |
### Instruction:
Is psychiatric morbidity related to a chain of prenatal and perinatal adversities?
### Response:
| Research and prevention strategies should not focus solely on isolated early risk factors, but also on the entire pre- and perinatal situation. |
### Instruction:
Is increased disease activity associated with a deteriorated lipid profile in patients with ankylosing spondylitis?
### Response:
| Increase in disease activity was associated with decreases in lipid levels. The decrease in HDLc levels tended to be almost twice as large as the decrease in total cholesterol levels, resulting in a more atherogenic lipid profile. Hence, effective treatment of disease activity in patients with ankylosing spondylitis may lower the cardiovascular risk by improving the lipid profile. |
### Instruction:
Is prolonged indomethacin exposure associated with decreased white matter injury detected with magnetic resonance imaging in premature newborns at 24 to 28 weeks ' gestation at birth?
### Response:
| In this observational study, a longer duration of indomethacin exposure was associated with less white matter injury in infants delivered before 28 weeks' gestation. A randomized trial of prolonged indomethacin treatment is needed to determine whether indomethacin can decrease white matter injury and neurodevelopmental abnormalities. |
### Instruction:
Does a clinical screening tool identify autoimmune diabetes in adults?
### Response:
| At least two distinguishing clinical features are found in a majority of patients with LADA at diagnosis and can be used to identify adults with diabetes at higher risk for LADA. |
### Instruction:
Do mealtime interactions relate to dietary adherence and glycemic control in young children with type 1 diabetes?
### Response:
| This was the first study to examine the relationship between parent-child mealtime interactions and health outcomes in young children with type 1 diabetes. The mealtime problems examined can be improved through specific behavioral interventions. Future research is needed to examine how parent-child interactions at mealtimes relate to children's health outcomes to inform clinical care. |
### Instruction:
Does sepsis-induced lung injury in rats increase alveolar epithelial vulnerability to stretch?
### Response:
| AECs isolated from septic rats are more vulnerable to mechanical deformation injury than AECs from nonseptic animals. |
### Instruction:
Does pLZF regulate Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation?
### Response:
| Androgen-independent cell line DU145 cells lack PLZF gene expression, resulting in the upregulation of Pbx1 and HoxC8 expression. The Pbx1-HoxC8 heterocomplex may lead to androgen-independent growth in prostate cancer. |
### Instruction:
Does consumption of both resistant starch and beta-glucan improve postprandial plasma glucose and insulin in women?
### Response:
| Soluble fiber appears to have a greater effect on postprandial insulin response while glucose reduction is greater after resistant starch from high-amylose cornstarch. The reduction in glycemic response was enhanced by combining resistant starch and soluble fiber. Consumption of foods containing moderate amounts of these fibers may improve glucose metabolism in both normal and overweight women. |
### Instruction:
Is obesity a risk factor for reporting homebound status among community-dwelling older persons?
### Response:
| Obesity remained a significant independent predictor for reporting homebound status and should be considered in screening of older populations and in the planning, implementation, and evaluation of services for homebound older persons. |
### Instruction:
Do barley and rye prolamins induce an mRNA interferon-gamma response in coeliac mucosa?
### Response:
| The findings of this study provide evidence that barley and rye cause immune activation in the mucosa of coeliac patients and support the practice that barley and rye should be excluded from the gluten-free diet. |
### Instruction:
Do alberta rodeo athletes develop the chronic whiplash syndrome?
### Response:
| Rodeo athletes appear to be in at least as many motor vehicle collisions as rodeo spectators, and 33% suffered the acute whiplash syndrome. Rodeo athletes appear, however, to be more resistant than spectators to developing prolonged pain and disability. |
### Instruction:
Does aLDH2 promoter polymorphism have no effect on the risk for alcoholism?
### Response:
| These results suggest the ALDH2 promoter polymorphism does not affect the risk for alcoholism. |
### Instruction:
Are pHosphatidylethanol ( PEth ) concentrations in blood correlated to reported alcohol intake in alcohol-dependent patients?
### Response:
| Blood concentrations of PEth are highly correlated to ethanol intake, and the present results indicate that its diagnostic sensitivity is higher than that for previously established alcohol markers. |
### Instruction:
Does iloprost attenuate doxorubicin-induced cardiac injury in a murine model without compromising tumour suppression?
### Response:
| In a murine model, iloprost attenuated the acute cardiac injury and dysfunction induced by DOX therapy without compromising its chemotherapeutic effect. |
### Instruction:
Is pre-hospital thrombolysis delivered by paramedics associated with reduced time delay and mortality in ambulance-transported real-life patients with ST-elevation myocardial infarction?
### Response:
| When compared with regular in-hospital thrombolysis, pre-hospital diagnosis and thrombolysis with trained paramedics in the ambulances are associated with reduced time to thrombolysis by almost 1 h and reduced adjusted 1-year mortality by 30% in real-life STEMI patients. |
### Instruction:
Does depletion of pulmonary intravascular macrophages prevent hyperacute pulmonary xenograft dysfunction?
### Response:
| These findings indicate that donor macrophages play a critical role in pulmonary xenograft dysfunction. This finding has broad implications for xenotransplantation, suggesting that porcine macrophages might pose a barrier to the engraftment and function of a variety of porcine organ xenografts. |
### Instruction:
Do prior events predict cerebrovascular and coronary outcomes in the PROGRESS trial?
### Response:
| Patients with previous vascular events are at high risk of recurrences of the same event. However, because they are also at risk of other vascular outcomes, a broad range of secondary prevention strategies is necessary for their treatment. BP-lowering is likely to be one of the most effective and generalizable strategies across a variety of major vascular events including stroke and myocardial infarction. |
### Instruction:
Does regular transfusion lower plasma free hemoglobin in children with sickle-cell disease at risk for stroke?
### Response:
| Regular transfusion which lowers stroke risk is associated with a significant reduction in PFH. A role for PFH in promoting stroke in SCD should be investigated. |
### Instruction:
Does pall leukotrap affinity prion-reduction filter remove exogenous infectious prions and endogenous infectivity from red cell concentrates?
### Response:
| The use of this new prion-reduction filter should reduce the risk of vCJD transmission through transfusion of RCC, the most widely transfused blood component. |
### Instruction:
Is a short course of oral prednisone followed by intranasal budesonide an effective treatment of severe nasal polyps?
### Response:
| A short course of oral steroids improved all nasal symptoms, polyp size, and nasal flow, whereas intranasal steroid maintain this effect. |
### Instruction:
Does cXC chemokine receptor CXCR4 expression enhance tumorigenesis and angiogenesis of basal cell carcinoma?
### Response:
| CXCR4 expression may play a critical role in tumour progression and angiogenesis of certain subtypes of BCC with more aggressive nature, and functional blockade of CXCR4 could be a potential therapeutic strategy for these tumours. |
### Instruction:
Is viral mRNA expression but not DNA replication required for lipogenic effect of human adenovirus Ad-36 in preadipocytes?
### Response:
| In conclusion, viral mRNA expression, although transient, is a prerequisite for enhancing differentiation of preadipocytes by Ad-36. Viral DNA replication was not required for the effect. This is the first evidence for the role of gene expression of an adipogenic human virus in enhancing preadipocytes differentiation. This study provides the basis for further understanding novel regulatory modulators of preadipocytes differentiation. |
### Instruction:
Does epigallocatechin gallate protect dopaminergic neurons against 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity by inhibiting microglial cell activation?
### Response:
| EGCG exerts potent dopaminergic neuroprotective activity by means of microglial inhibition, which shed light on the potential use of EGCG in treatment of Parkinson's disease. |
### Instruction:
Does treatment of eating disorders improve eating symptoms but not alexithymia and dissociation proneness?
### Response:
| The combined intervention was efficient in our sample of patients with eating disorder despite the small sample size. The aforementioned specific psychometric change may be indicative of the lack of importance of changes in AL or dissociation proneness in the short-term improvement in patients with eating disorder. |
### Instruction:
Is microcoagulation of junctional dorsal root entry zone effective treatment of brachial plexus avulsion pain : long-term follow-up study?
### Response:
| The long-term follow up showed that the pain relief gradually decreased over 5 years after surgery. However, the pain relief still did not significantly decrease after 3 years. |
### Instruction:
Do electrocardiographic abnormalities predict deaths from cardiovascular disease and ischemic heart disease in Pima Indians with type 2 diabetes?
### Response:
| The CVD and IHD death rates were higher in men and in subjects with major ischemic ECG abnormalities. Major ischemic abnormalities on ECG predicted death after accounting for other cardiovascular risk factors, including proteinuria. |
### Instruction:
Does breast milk provide better antioxidant power than does formula?
### Response:
| Our data suggest that breast milk provides better antioxidant power than does formula. |
### Instruction:
Does clinical judgment remain of great value in the diagnosis of acute appendicitis?
### Response:
| In the context of limited available medical imaging modalities, clinical observation was not associated with an increased incidence of complicated appendicitis. The presence of complicated appendicitis was associated with the delay before the patient's first medical consultation. Clinical judgment can be prioritized and can lead to good clinical performance in the management of patients with suspected appendicitis, with no significant increase in rates of complicated appendicitis and negative findings on appendectomy. |
### Instruction:
Does a coding polymorphism in matrix metalloproteinase 9 reduce risk of scarring sequelae of ocular Chlamydia trachomatis infection?
### Response:
| This work supports the hypothesis that MMP-9 has a role in the pathogenesis of blinding trachoma. |
### Instruction:
Does transparent and open discussion of errors increase malpractice risk in trauma patients?
### Response:
| A transparent discussion of errors, complications, and deaths does not appear to lead to an increased risk of lawsuit. |
### Instruction:
Does dietary fiber enhance a tumor suppressor signaling pathway in the gut?
### Response:
| These results demonstrate that NaB induces Smad3 and potentiates TGF-beta signaling and its tumor suppressor activity in gut epithelial cells. Our data reveal a novel molecular mechanism that may explain in part the beneficial effects of dietary fiber in decreasing the risk of colon cancers. |
### Instruction:
Does angiotensin II enhance carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits?
### Response:
| These results indicate that elevation of Ang II and concomitant upregulation of AT1 receptor in the CB contribute to the increased CB chemoreceptor activity and enhanced peripheral chemoreflex function in CHF. |
### Instruction:
Does expression of polo-like kinase 1 ( PLK1 ) protein predict the survival of patients with gastric carcinoma?
### Response:
| PLK1 expression may be a critical indicator of a poor prognosis in patients with gastric carcinoma. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.