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### Instruction:
Is narrow subpubic arch angle associated with higher risk of persistent occiput posterior position at delivery?
### Response:
| A narrow SPA is associated with a higher risk of persistent OP position at delivery and of operative delivery. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd. |
### Instruction:
Are sleep Parameters , Functional Status , and Time Post-Stroke Associated with Offline Motor Skill Learning in People with Chronic Stroke?
### Response:
| This study is the first study to provide insight into which sleep stages and individual characteristics may be associated with offline learning in people with stroke. Further research is needed to delineate which factors or combination of factors promote offline motor learning in people with neurologic injury to best p... |
### Instruction:
Is osteosarcopenia more than sarcopenia and osteopenia alone?
### Response:
| Due to low physical performance and high bone turnover, older adults with osteosarcopenia have to be regarded as the most at-risk population for fractures and further functional decline. |
### Instruction:
Are vEGF Gene Polymorphisms Associated with Risk of Tetralogy of Fallot?
### Response:
| Our results confirmed that VEGF genetic polymorphisms, -2578C>A and -634C>G, may be associated with an increased TOF risk, while 936C>T polymorphism may be associated with decreased TOF risk. |
### Instruction:
Does neoadjuvant Systemic Therapy Before Radical Prostatectomy in High-Risk Prostate Cancer Increase Surgical Morbidity : Contemporary Results Using the Clavien System?
### Response:
| The use of neoadjuvant systemic therapy did not appear to increase the risk of perioperative complications. These findings support current clinical trials, which might elucidate the oncologic benefit of this multimodality approach. |
### Instruction:
Does modal damping factor detected with an impulse-forced vibration method provide additional information on osseointegration during dental implant healing?
### Response:
| Analysis of RF combined with MDF provides additional information on dental implant healing status. MDF analysis can detect changes in the implant/bone complex during the healing period even in implants with higher RF values. |
### Instruction:
Is failure to meet language milestones at two years of age predictive of specific language impairment?
### Response:
| Failure to meet language milestones from the age of 24 months was predictive of SLI, but the use of separate milestones had limited value due to low sensitivity. |
### Instruction:
Do eWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions?
### Response:
| The presented results yield new insights into gene interactions of EWS and FUS and have identified a set of FUS and EWS target genes involved in pathways at the RNA regulatory level with potential to mediate normal and disease-associated functions of the FUS and EWS proteins. |
### Instruction:
Do bayesian analyses of Yemeni mitochondrial genomes suggest multiple migration events with Africa and Western Eurasia?
### Response:
| Yemeni mitogenomes are largely the product of Holocene migration, and subsequent in situ evolution, from Africa and western Eurasia. However, we hypothesize that recent population movements may obscure the genetic signature of more ancient migrations. Additional research, e.g., analyses of Yemeni nuclear genetic data, ... |
### Instruction:
Does nADPH Oxidase-Mediated ROS Production determine Insulin 's Action on the Retinal Microvasculature?
### Response:
| The increased formation of NO by insulin and its suppression by high glucose conditions suggests that ROS production mediated by NADPH oxidase is important by insulin's effect on the retinal microvasculature. |
### Instruction:
Is baseline serum interleukin-6 to interleukin-2 ratio associated with the response to seasonal trivalent influenza vaccine in solid organ transplant recipients?
### Response:
| Baseline serum IL-6 and IL-2 levels, two cytokines that modulate the role of CD4(+) T follicular helper cells and the terminal differentiation of B-cells, predict vaccine response in SOT recipients. |
### Instruction:
Does igM-enriched solution BT086 improve host defense capacity and energy store preservation in a rabbit model of endotoxemia?
### Response:
| Our data suggest that the IgM-enriched IVIG has the potential to improve host defense in a rabbit model of endotoxemia. Studies using different animal models and dosages are necessary to further explore the potential benefits of IgM-enriched IVIG solutions. |
### Instruction:
Does tAS2R38 genotype predict surgical outcome in nonpolypoid chronic rhinosinusitis?
### Response:
| In patients undergoing sinus surgery for CRS, we have identified a genetic polymorphism that predicts variability in quality of life improvement following surgery at 6 months in nonpolypoid CRS. This is the first genetic polymorphism identified that has demonstrated to predict surgical outcome for a select group of CRS... |
### Instruction:
Does ursolic acid improve podocyte injury caused by high glucose?
### Response:
| Our data suggest that podocyte injury is associated with reduced levels of autophagy during exposure to high glucose conditions, UA attenuated podocyte injury via an increase in autophagy through miR-21 inhibition and PTEN expression, which inhibit the abnormal activation of the PI3K/Akt/mTOR pathway. |
### Instruction:
Does dual time point imaging for F18-FDG-PET/CT improve the accuracy of nodal staging in non-small cell lung cancer patients?
### Response:
| Using a modern PET/CT device and novel image reconstruction, neither additional delayed PET nor DTPI analyses improved the accuracy of PET-based LN staging. Dedicated visual assessment criteria performed very well. |
### Instruction:
Are free thiol groups in von Willebrand factor ( VWF ) required for its full function under physiological flow conditions?
### Response:
| This study shows a significant contribution of free thiol groups in VWF to the mediation of platelet adhesion under physiological shear stress conditions. The free thiol groups are shown to be involved in VWF binding to both collagen III and platelet GP1b receptor. |
### Instruction:
Is hyperglycemia a risk factor for high-grade envenomations after European viper bites ( Vipera spp . ) in children?
### Response:
| We have confirmed a potential link between initial hyperglycemia and the risk of progression to high-grade envenomation as well as its association with other published predictive factors. |
### Instruction:
Does enrollment with a primary care provider preclude ED visits for patients with woman 's health-related problems?
### Response:
| Enrollment with a primary care provider alone does not eliminate the need for ED use in women with health-related conditions. |
### Instruction:
Is cXCR4 Expression Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma?
### Response:
| CXCR4 expression is associated with poor prognosis in patients with ESCC. |
### Instruction:
Does intravitreal Ciliary Neurotrophic Factor Transiently improve Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia?
### Response:
| Intravitreal bolus CNTF protein caused a small and transient improvement of cone-mediated function in CNGB3-/- mice, whereas it reduced rod-mediated function. The increase in photopic OPs and the lack of changes in scotopic a-wave suggest a CNTF effect on the inner retina. |
### Instruction:
Does hepatitis C virus core protein modulate pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation?
### Response:
| HCV core appears indeed able to significantly down-regulate the expression and the function of two out of three RB family tumor and growth suppressor factors, i.e. pRb and pRb2/p130. The functional consequences at the level of cell cycle regulation, and possibly of more complex cell homeostatic processes, may represent... |
### Instruction:
Is intradermal microbubbles and contrast-enhanced ultrasound ( CEUS ) a feasible approach for sentinel lymph node identification in early-stage breast cancer?
### Response:
| Microbubbles and CEUS are feasible approaches for SLN identification. The enhancing patterns on CEUS may be helpful to recognize the metastasizing SLNs. This novel method may be a promising technique for the clinical application. |
### Instruction:
Do [ Determinants of maternal near miss in an obstetric intensive care unit ]?
### Response:
| The prevalence of near miss was associated with socioeconomic/clinical factors and care issues, revealing the importance of interventions to improve these indicators. Additionally, we suggest a better curriculum insertion of this subject in the discipline of the medical course due to the importance of avoiding the near... |
### Instruction:
Does early Moderate Hyperoxemia Predict Outcome After Aneurysmal Subarachnoid Hemorrhage?
### Response:
| Early moderate hyperoxemia may not increase or decrease the risk of a poor outcome in mechanically ventilated aneurysmal SAH patients. |
### Instruction:
Do primary health care teams put to the test a cross-sectional study from Austria within the QUALICOPC project?
### Response:
| This study gives insight into the structures of PHC in Austria. The results indicate a low number of PHCT; however, the overall return rate in our sample was low with more male GPs, more GPs from urban areas and more GPs working in offices together with other physicians than the national average. Younger GPs demonstrat... |
### Instruction:
Do propranolol and Mesenchymal Stromal Cells Combine to Treat Traumatic Brain Injury?
### Response:
| Despite continuous efforts, traumatic brain injury (TBI) remains the leading cause of death and disability worldwide in patients under the age of 44. In this study, an animal model of moderate-severe TBI was treated with an acute dose of propranolol followed by a delayed dose of human mesenchymal stem cells (MSCs), res... |
### Instruction:
Does trimetazidine prevent macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1?
### Response:
| TMZ protected against LPS-induced myocardial dysfunction and apoptosis, accompanied by inhibition of macrophage pro-inflammatory responses. Our studies suggest that TMZ might represent a novel therapeutic agent to prevent and treat sepsis-induced myocardial dysfunction. |
### Instruction:
Does myeloperoxidase negatively regulate the expression of proinflammatory cytokines and chemokines by zymosan-induced mouse neutrophils?
### Response:
| MPO deficiency upregulates the expression of several proinflammatory cytokines and chemokines in mouse neutrophils. |
### Instruction:
Is obesity associated with prolonged activity of the quadriceps and gastrocnemii during gait?
### Response:
| Obesity was associated with prolonged activation of quadriceps and gastrocnemii, which can result in prolonged knee joint contact loading, and thereby may contribute to the predisposition of knee OA development and progression in obese individuals. |
### Instruction:
Does promoter Methylation Analysis reveal That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation?
### Response:
| This study demonstrates that promoters of ion channels are aberrantly methylated in Ewing sarcoma and that epigenetic silencing of KCNA5 contributes to tumor cell proliferation, thus providing further evidence of the importance of ion channel dysregulation to tumorigenesis. |
### Instruction:
Does microRNA-221 regulate Hypertrophy of Ligamentum Flavum in Lumbar Spinal Stenosis by Targeting TIMP-2?
### Response:
| The downregulation of miR-221 might contribute to LF hypertrophy by promoting collagens I and III expression via the induction of TIMP-2. Our study also underscores the potential of miR-221 as a novel therapeutic target in LSS. |
### Instruction:
Is treatment of Clostridium difficile infection in mice with vancomycin alone as effective as treatment with vancomycin and metronidazole in combination?
### Response:
| Mice treated with vancomycin alone had a better clinical outcome in the treatment phase of CDI than mice treated with metronidazole alone. A combination of vancomycin and metronidazole did not improve the clinical outcome when compared to treatment with vancomycin alone. |
### Instruction:
Do perception of the pitch and naturalness of popular music by cochlear implant users?
### Response:
| The pitch ratings for the default allocation suggest that participants have acclimatized to their processors' frequency allocations. Adjustment of the pitch of the song was possible for the majority and suggested that all but one participant was experiencing frequency compression. Expansion of the frequency allocation ... |
### Instruction:
Do contribution of hearing aids to music perception by cochlear implant users?
### Response:
| These results show that, for CI recipients with aidable hearing in the non-implanted ear, using a HA in addition to their implant improves perception of musical pitch and recognition of real-world melodies. |
### Instruction:
Does normal fasting plasma glucose predict type 2 diabetes and cardiovascular disease in elderly population in Taiwan?
### Response:
| Our results suggest that FPG within the normal range was associated with MetS, and elderly subjects with high normal levels have a higher incidence of developing T2D for both sexes, and CVD for females, over the short-term. |
### Instruction:
Do peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma?
### Response:
| Our results indicate that the tumour microenvironment induces impaired antitumour immunity via the modulation of PD-L1 expression on tumour infiltrating neutrophils. |
### Instruction:
Do osteogenic progenitors in bone marrow aspirates have clinical potential for tibial non-unions healing in diabetic patients?
### Response:
| We recommend that diabetic patients be treated with an increased number of progenitor cells by increasing the bone marrow aspiration volume. We also anticipate a need to extend the time of casting and non-weight bearing for diabetic patients as compared with non-diabetic patients. |
### Instruction:
Are patients with familial hypercholesterolaemia characterized by presence of cardiovascular disease at the time of death?
### Response:
| Cardiovascular disease is present in most FH patients at the time of death, underscoring the severity of FH and the need for early diagnosis and treatment. |
### Instruction:
Is serum IGF-1 higher in patients with idiopathic normal pressure hydrocephalus than in the population?
### Response:
| Patients with iNPH did not have lower levels of pituitary or sex hormones but presented with higher levels of S-IGF-1, compared with healthy, age-matched controls. Higher S-IGF-1 in men was related to milder mental and physical symptoms and signs. |
### Instruction:
Is von Willebrand factor associated with atrial fibrillation development in ischaemic patients after cardiac surgery?
### Response:
| Plasma vWF levels are associated with tissue fibrosis in patients undergoing cardiac surgery and with post-surgical AF development in ischaemic patients. These findings suggest an association among vWF levels, atrial remodelling, and AF development. It is supported by higher vWF expression in right atrial tissue in isc... |
### Instruction:
Is current tobacco use associated with higher rates of implant revision and deep infection after total hip or knee arthroplasty : a prospective cohort study?
### Response:
| We noted that current tobacco use was associated with high risk of deep infection and implant revision after primary THA or TKA. Future studies should determine the optimal time for tobacco use cessation before elective surgeries such as THA and TKA to improve short-term and long-term arthroplasty outcomes. |
### Instruction:
Is thrombospondin-1 a glucocorticoid responsive protein in humans?
### Response:
| TSP1 is a glucocorticoid responsive protein in humans. Further research is required to determine if plasma TSP1 has a role as a glucocorticoid biomarker. |
### Instruction:
Does miR-20a regulate expression of the iron exporter ferroportin in lung cancer?
### Response:
| miR-20a controls expression of the iron exporter ferroportin (FPN) by binding to highly conserved target sites in its 3'UTR. Expression of miR-20a is inversely correlated to FPN in lung cancer. Low FPN expression stimulates proliferation and colony formation of non-small cell lung cancer (NSCLC) cells, possibly by incr... |
### Instruction:
Do oxidative Modifications of Protein Tyrosyl Residues Are Increased in Plasma of Human Subjects with Interstitial Lung Disease?
### Response:
| We demonstrate an increase in oxidized tyrosine moieties within proteins in the circulating plasma of patients with ILD. These data support the potential for development of oxidative stress-related biomarkers in early diagnosis, prognostication, and/or in evaluating responsiveness to emerging therapies for ILD. |
### Instruction:
Does miR-125b be Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis?
### Response:
| In conclusion, miR-125b is critical for induction of cardiac fibrosis and acts as a potent repressor of multiple anti-fibrotic mechanisms. Inhibition of miR-125b may represent a novel therapeutic approach for the treatment of human cardiac fibrosis and other fibrotic diseases. |
### Instruction:
Does neuropilin-2 induced by transforming growth factor-β augment migration of hepatocellular carcinoma cells?
### Response:
| These data suggest that NRP2 associates with a less differentiated, mesenchymal-like HCC phenotype and that NRP2 plays an important role in tumor cell migration upon TGF-β-dependent HCC progression. |
### Instruction:
Are stromal markers AKR1C1 and AKR1C2 prognostic factors in primary human breast cancer?
### Response:
| It can be assumed that our observations are due to the independent regulatory function of AKR1C1/2 in progesterone metabolism and therefore provide a basis for new hormone-based therapy options for breast cancer patients, independent of classic hormone receptor status. |
### Instruction:
Is rs12976445 Polymorphism Associated with Risk of Diabetic Nephropathy Through Modulating Expression of MicroRNA-125 and Interleukin-6R?
### Response:
| We identified miR-125a as a direct regulator of IL-6R, and the genotype of rs12976445 might be a novel predictor of the development of DN in DM. |
### Instruction:
Does mammographic density defined by higher than conventional brightness threshold better predict breast cancer risk for full-field digital mammograms?
### Response:
| Altocumulus measures perform better than Cumulus measures in predicting breast cancer risk, and Cumulus measures are confounded by Altocumulus measures. The mammographically bright regions might be more aetiologically important for breast cancer, with implications for biological, molecular, genetic and epidemiological ... |
### Instruction:
Do nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide?
### Response:
| ITK and BTK regulate thermal homeostasis during septic response through mast cell function in mice. They share regulatory function downstream of Toll-like receptor 4/LPS in mast cells, through regulating the activation of canonical nuclear factor kappa B, phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt, and p38 sign... |
### Instruction:
Does mechanical stretch-induced vascular hypertrophy occur through modulation of leptin synthesis-mediated ROS formation and GATA-4 nuclear translocation?
### Response:
| Our results demonstrate that ROS formation, RhoA/ROCK pathway, and GATA-4 activation play a pivotal role in mechanical stretch-induced leptin synthesis leading to VSMC remodeling. |
### Instruction:
Does desflurane allow for a Faster Emergence When Compared to Sevoflurane without Affecting the Baseline Cognitive Recovery Time?
### Response:
| We re-confirmed that patients receiving desflurane had a faster emergence and met the criteria to be discharged from the PACU earlier. No difference was found in time to return to baseline cognition between desflurane and sevoflurane. |
### Instruction:
Is radiation-Induced Esophagitis Mitigated by Soy Isoflavones?
### Response:
| Soy isoflavones have a radioprotective effect on the esophagus, mitigating the early and late effects of radiation injury in several esophagus tissue layers. Soy could be administered with radiotherapy to decrease the incidence and severity of esophagitis in lung cancer patients receiving thoracic radiation therapy. |
### Instruction:
Does deep sequencing of small RNA facilitate tissue and sex associated microRNA discovery in zebrafish?
### Response:
| This study comprehensively identifies tissue and sex associated miRNAs in zebrafish. Further, we have discovered 459 novel pre-miRNAs (~30 % seed homology to human miRNA) as a genomic resource which can facilitate further investigations to understand miRNA-mRNA gene regulatory networks in zebrafish which will have impl... |
### Instruction:
Does calcium supplementation modulate gut microbiota in a prebiotic manner in dietary obese mice?
### Response:
| In conclusion, calcium modulated gut microbiota in a prebiotic manner, establishing a host cross-talk and promoting a healthier metabolic profile. However, lack of effectiveness of FMT suggests the need of further appropriate dietary factors in addition to the bacteria per se. |
### Instruction:
Does the alignment of enzymatic steps reveal similar metabolic pathways and probable recruitment events in Gammaproteobacteria?
### Response:
| From these comparisons, we identified a set of functionally conserved enzymatic steps in different metabolic maps, in which cell wall components and fatty acid and lysine biosynthesis were included. In addition, we found that pathways associated with biosynthesis share a higher proportion of similar ESS than degradatio... |
### Instruction:
Does a large scale prediction of bacteriocin gene block suggests a wide functional spectrum for bacteriocins?
### Response:
| We provide a novel dataset of predicted bacteriocins and context genes. We also discover that several phyla have a strong preference for bacteriocin genes, suggesting distinct functions for this group of molecules. |
### Instruction:
Does phosphodiesterase-5 inhibition improve macrocirculation and microcirculation during cardiopulmonary resuscitation?
### Response:
| Sildenafil increases the success of resuscitation through improving macrocirculation and microcirculation during VF and CPR. There is a close relationship between microvascular flow and CPP during CPR. |
### Instruction:
Does propofol affect Different Human Brain Regions Depending on Depth of Sedation ( △ )?
### Response:
| Mild and deep propofol sedation are associated with inhibition of different brain regions, possibly explaining differences in the respective loss of consciousness processes. |
### Instruction:
Does a fast method for calculating reliable event support in tree reconciliations via Pareto optimality?
### Response:
| We propose a new approach to improve the accuracy of event supports for parsimonious reconciliation methods to account for uncertainty in the input costs. Furthermore, because of their speed, our methods can be used on large gene families. Our algorithms are implemented in the ecceTERA program, freely available from ht... |
### Instruction:
Does dedicated Spine Measurement Software quantify Key Spino-Pelvic Parameters More Reliably Than Traditional Picture Archiving and Communication Systems Tools?
### Response:
| SMS provides significantly more reliable measurements than PACS, especially among surgeons. Consistent use of SMS in the evaluation and surgical planning of ASD patients appears necessary given the significant differences in values, variance, and reliability between PACS and SMS. |
### Instruction:
Does combined Analysis of Plasma Amphiregulin and Heregulin predict Response to Cetuximab in Metastatic Colorectal Cancer?
### Response:
| A subgroup of CRC patients with high amphiregulin and low heregulin respond to cetuximab therapy better than other patients. |
### Instruction:
Do transvaginal mesh in the media following the 2011 US food and drug administration public health notification update?
### Response:
| Despite frequent media coverage of transvaginal mesh and its complications since 2011, very few news sources that cited the FDA warning distinguished between prolapse and incontinence. Given prevalent reporting of mesh-related litigation, the findings raise concern about how patients perceive the safety and efficacy of... |
### Instruction:
Does the radiogenomic risk score stratify outcomes in a renal cell cancer phase 2 clinical trial?
### Response:
| The RRS stratifies rPFS to bevacizumab in patients from a phase II clinical trial with mRCC undergoing cytoreductive nephrectomy and pre-surgical bevacizumab. |
### Instruction:
Does interleukin-27 ameliorate coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells?
### Response:
| Our results demonstrate that that IL-27 effectively protects the myocardium from the pathogenesis of CVB3 induced myocarditis, which may be attributable to reduced Th17 production. IL-27 might serve as a novel therapeutic treatment for VMC. |
### Instruction:
Is the expression of B23 and EGR1 proteins functionally linked in tumor cells under stress conditions?
### Response:
| Our results highlight EGR1 as a regulator of B23 expression actively playing within the newly discovered nucleolar B23-ARF-EGR1 network. |
### Instruction:
Is surgeon personality associated with recommendation for operative treatment?
### Response:
| A recommendation for discretionary surgery for musculoskeletal injury was related to surgeon personality. Surgeon self-awareness of how their work style can influence their recommendations might make them more receptive to techniques that ensure patient values have more influence than surgeon preferences on treatment d... |
### Instruction:
Is variant of PAI-2 gene associated with coronary artery disease and recurrent coronary event risk in Chinese Han population?
### Response:
| We firstly found that the variant of PAI-2 gene was associated with CAD and recurrent coronary event risk in Chinese Han population, in Xinjiang. |
### Instruction:
Does durability of Infliximab be Associated With Disease Extent in Children With Inflammatory Bowel Disease?
### Response:
| Patients with extensive disease started taking 5 mg/kg of IFX were more likely to require dose escalation compared to those with limited or moderate disease. All of the patients with moderate and extensive disease started taking 10 mg/kg of IFX remained on this dose. These results suggest that patients with more extens... |
### Instruction:
Does endurance Exercise reduce Hepatic Fat Content and Serum Fibroblast Growth Factor 21 Levels in Elderly Men?
### Response:
| A 5-week endurance exercise program decreased hepatic fat content and serum FGF21 levels without weight loss in elderly men, and exercise-induced hepatic fat reduction mediated the reduction in serum FGF21 levels. These findings suggest that endurance exercise modulates hepatic fat content and FGF21 resistance, regardl... |
### Instruction:
Does dual PI3K/mTOR inhibitor BEZ235 exert extensive antitumor activity in HER2-positive gastric cancer?
### Response:
| The present study has demonstrated, for the first time, the antitumor activity of BEZ235 against HER2-positive gastric cancer in patient-derived xenografts, as well its synergistic interaction with trastuzumab. These important findings can be utilized to facilitate the design of future clinical trials. |
### Instruction:
Does minocycline inhibit Inflammation and Squamous Metaplasia of Conjunctival Tissue Culture in Airlift Conditions?
### Response:
| These findings highlight the possibility that minocycline could be used to treat dry eye and other ocular surface diseases exhibiting epithelial cell inflammation and squamous metaplasia. |
### Instruction:
Does prolonged Subdural Infusion of Kynurenic Acid be Associated with Dose-Dependent Myelin Damage in the Rat Spinal Cord?
### Response:
| We suggest, that subdural infusion of high dose of KYNA can be used as an experimental tool for the study of mechanisms of myelin damage and regeneration. On the other hand, the administration of low, physiologically relevant doses of KYNA may help to discover the role of KYNA in control of physiological myelination pr... |
### Instruction:
Does short Duration Combined Mild Hypothermia improve Resuscitation Outcomes in a Porcine Model of Prolonged Cardiac Arrest?
### Response:
| Short duration combined cooling initiated after resuscitation improves survival and neurological outcomes in a porcine model of prolonged VF. |
### Instruction:
Are healthcare professionals less confident in managing acute toxicity related to the use of new psychoactive substances ( NPS ) compared with classical recreational drugs?
### Response:
| Physicians/nurses are less confident in managing acute NPS toxicity. Management of toxicity is not dependent on knowing the drug/NPS, but should be on the basis of these clinical signs/symptoms. Training/education should focus on the concept of managing the pattern of toxicity that an individual presents with rather th... |
### Instruction:
Does bedside Ultrasound reduce Diagnostic Uncertainty and Guides Resuscitation in Patients With Undifferentiated Hypotension?
### Response:
| Clinical management involving the early use of ultrasound in patients with hypotension accurately guides diagnosis, significantly reduces physicians' diagnostic uncertainty, and substantially changes management and resource utilization in the emergency department. |
### Instruction:
Do cochlear implant users rely on tempo rather than on pitch information during perception of musical emotion?
### Response:
| The results suggest that the CI group relied more heavily on tempo than mode in making musical emotion decisions. The subgroup analysis further suggests that level of musical training did not significantly impact this finding. |
### Instruction:
Do use of the Phantom Electrode strategy to improve bass frequency perception for music listening in cochlear implant users?
### Response:
| Creation of a Phantom Electrode percept through partial bipolar stimulation of the two most apical electrodes appears to improve CI users' perception of bass frequency information in music, contributing to greater accuracy in the ability to detect alterations in musical sound quality. |
### Instruction:
Is a High RORγT/CD3 Ratio a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer : Analysis of Helper T Cell Lymphocytes ( Th1 , Th2 , Th17 and Regulatory T Cells )?
### Response:
| This study confirmed a high RORγT/CD3 ratio as a strong prognostic marker for postoperative survival. The immunohistochemistry results suggest that Th17 may affect lymph node metastasis in CRC. If new immunotherapies reducing Th17 expression are established, they may improve the efficiency of cancer treatment and prolo... |
### Instruction:
Is threonine532 phosphorylation in ClC-3 channels required for angiotensin II-induced Cl ( - ) current and migration in cultured vascular smooth muscle cells?
### Response:
| ClC-3 protein phosphorylation at Thr(532) by ROCK2 is required for AngII-induced Cl(-) current and VSMC migration that are involved in AngII-induced vascular remodelling in hypertension. |
### Instruction:
Does hCLOCK cause Rho-Kinase-Mediated Endothelial Dysfunction and NF-κB-Mediated Inflammatory Responses?
### Response:
| Our findings suggest that hypoxic states induce vascular oxidative damage and inflammation via hCLOCK-mediated production of ROS, with subsequent activation of the RhoA and NF-κB pathways. |
### Instruction:
Are the course of social cognitive and metacognitive ability in depression : Deficit only partially normalized after full remission of first episode major depression?
### Response:
| Overall, results suggests that social cognitive and metacognitive ability may improve with symptom remission in major depression although it may not reach a level equal to persons who have never experienced depression. |
### Instruction:
Does expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveal modest age-dependent decreases in specific neurons?
### Response:
| These studies represent the first protein expression profiling of a ubiquitin-conjugating enzyme in the brain and support the notion that deficits in protein degradation and proteostasis associated with neurodegenerative diseases may be, in part, attributable to age-dependent reductions in the enzymatic machinery of th... |
### Instruction:
Does genome-wide profiling in treatment-naive early rheumatoid arthritis reveal DNA methylome changes in T and B lymphocytes?
### Response:
| Treatment-naive early RA patients display novel disease-specific DNA methylation aberrations, supporting a potential role for these changes in the development of RA. |
### Instruction:
Is aTP generation in a host cell in early-phase infection increased by upregulation of cytochrome c oxidase activity via the p2 peptide from human immunodeficiency virus type 1 Gag?
### Response:
| These findings provide evidence that the p2 peptide is a viral positive allosteric modulator of MT-CO and the increased intracellular ATP production after HIV infection in a p2-peptide-dependent manner is essential for efficient reverse transcription in early-phase HIV-1 infection. |
### Instruction:
Does an investigation of causes of false positive single nucleotide polymorphisms using simulated read from a small eukaryote genome?
### Response:
| The choice of tools and parameters involved in variant calling can have a dramatic effect on the number of FP SNPs produced, with particularly poor combinations of software and/or parameter settings yielding tens of thousands in this experiment. Between-factor interactions make simple recommendations difficult for a SN... |
### Instruction:
Are unrecognized myocardial infarctions assessed by cardiovascular magnetic resonance associated with the severity of the stenosis in the supplying coronary artery?
### Response:
| UMI is common in patients with stable angina and the results indicate that the majority of the UMIs are of ischemic origin due to severe coronary atherosclerosis. In contrast to what is seen in recognized myocardial infarctions, UMIs are predominately located in the inferior and infero-lateral myocardial segments. |
### Instruction:
Do directors Recognize Difficulties in Providing Medical Care to Residents But Few Implement Policies to Address Them?
### Response:
| It is uncommon for directors to see residents as patients, but most who do feel comfortable with it. Other faculty physicians provide care more frequently. Directors acknowledge potential difficulties with this practice, but few have addressed these issues by creating specific policies. |
### Instruction:
Do 25-GAUGE PARS PLANA VITRECTOMY AND SF6 GAS FOR THE REPAIR OF PRIMARY INFERIOR RHEGMATOGENOUS RETINAL DETACHMENT?
### Response:
| Favorable results were achieved using 25-gauge vitrectomy and sulfur hexafluoride gas for primary RRD treatment. No differences in anatomical and functional success rates were observed between inferior and superior retinal break-associated RRD. |
### Instruction:
Do role of Percutaneous Glue Treatment After Persisting Leak After Laparoscopic Sleeve Gastrectomy?
### Response:
| Percutaneous glue treatment alone does not seem to provide adequate results. Stenting previous to the glue treatment allows for better results. |
### Instruction:
Does higher Eating Frequency Decrease Appetite in Healthy Adults?
### Response:
| The results from this study in 12 healthy adults do not support the popularized notion that small, frequent meals help to decrease overall appetite. This trial was registered at clinicaltrials.gov as NCT02548026. |
### Instruction:
Does oxaliplatin-induced Oxidative Stress provoke Toxicity in Isolated Rat Liver Mitochondria?
### Response:
| Oxidative stress plays an important role in the mitochondrial toxicity of oxaliplatin. The integrity of the hepatic tissue is compromised by the reactive oxygen species-mediated lipid peroxidation and protein carbonyl formation. |
### Instruction:
Are reduced sinonasal levels of 1α-hydroxylase associated with worse quality of life in chronic rhinosinusitis with nasal polyps?
### Response:
| Patients with CRSwNP and AFRS both have reduced sinonasal 1α-hydroxylase and 1,25VD3 compared to controls or CRSsNP. Reductions in intracellular 1α-hydroxylase combined from all sinonasal cell types were associated with more severe subjective disease severity in CRSwNP. |
### Instruction:
Does pomegranate peel extract decrease small intestine lipid peroxidation by enhancing activities of major antioxidant enzymes?
### Response:
| These findings demonstrate that intake of PPE in diet attenuates small intestine lipid peroxidation and strengthens the first line of small intestine antioxidant defense by enhancing enzymatic antioxidative pathways. PPE is worthy of further study as a therapeutic approach to prevent peroxidative stress-induced gut pat... |
### Instruction:
Do maternal and Birth Characteristics Are Determinants of Offspring Thyroid Function?
### Response:
| In this study, childhood thyroid function was predominantly determined by maternal TSH or FT4 levels and thyroid-specific single nucleotide polymorphisms. Effects of stress-related changes in thyroid function at birth were transient. Other potential factors were not associated with offspring thyroid function. |
### Instruction:
Does follicle-Stimulating Hormone induce Postmenopausal Dyslipidemia Through Inhibiting Hepatic Cholesterol Metabolism?
### Response:
| FSH may interact with its receptors in hepatocytes and reduce LDLR levels, which subsequently attenuates the endocytosis of LDL-C, resulting in an elevated circulating LDL-C level. |
### Instruction:
Do stimulated high serum thyroglobulin with negative whole body imaging warrant an aggressive diagnostic and therapeutic approach in differentiated thyroid cancer patients : A follow-up of 5 years or till recurrence?
### Response:
| High sTg with negative ¹³¹I WBS did not warrant an aggressive DTC disease. These patients in their 5 years or till recurrence follow-up showed downward trends of serum sTg, no higher risk or recurrence and no shorter PFS. |
### Instruction:
Does deep neuromuscular block improve the surgical conditions for laryngeal microsurgery?
### Response:
| Deep neuromuscular block (post-tetanic count of 1-2) surgical conditions in patients undergoing laryngeal microsurgery improves. |
### Instruction:
Does low Intensity Pulsed Ultrasound promote the Extracellular Matrix Synthesis of Degenerative Human Nucleus Pulposus Cells Through FAK/PI3K/Akt Pathway?
### Response:
| LIPUS promotes the ECM synthesis of degenerative human nucleus pulposus cells through activation of FAK/PI3K/Akt pathway. |
### Instruction:
Does urinary Output predict Survival in Patients Undergoing Extracorporeal Membrane Oxygenation Following Cardiovascular Surgery?
### Response:
| We identified 24-hour urinary output as a strong and easily available predictor of mortality in patients undergoing extracorporeal membrane oxygenation therapy following cardiovascular surgery. Implementation of 24-hour urinary output leads to a substantial improvement of established risk prediction models in this vuln... |
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