question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Do equiosmolar Solutions of Hypertonic Saline and Mannitol Impair Blood Coagulation During Elective Intracranial Surgery?
### Response:
| The use of 5 mL/kg of equiosmolar solutions of 3% HS and 20% mannitol applied to reach a brain relaxation during elective craniotomy does not induce coagulation impairment as evidenced by ROTEM and standard coagulation tests. |
### Instruction:
Are two highly adhesive lactic acid bacteria strains protective in zebrafish infected with Aeromonas hydrophila by evocation of gut mucosal immunity?
### Response:
| Our findings indicate highly adhesive strains of B. coagulans 09·712 and Lact. plantarum 08·923 have immunoregulatory and immunoprotective roles in effective stimulation of anti-inflammatory response and barrier regeneration within the mucosa to protect zebrafish against infection. |
### Instruction:
Is levels of bioactive lipids in cooking oils : olive oil the richest source of oleoyl serine?
### Response:
| Cooking oils contain varying levels of bioactive lipids from the N-acyl amide and 2-acyl glycerol families. Olive oil is a dietary source of OS, which may contribute to lowered prevalence of osteoporosis in countries with high consumption of this oil. |
### Instruction:
Are body fat mass and the proportion of very large adipocytes in pregnant women associated with gestational insulin resistance?
### Response:
| During pregnancy, adipose tissue morphology and function change comprehensively. NW women accumulated fat in existing adipocytes, accompanied by reduced adiponectin release. In comparison with the NW group, obese women had signs of adipocyte recruitment and maintained adiponectin levels. Body fat and large adipocytes m... |
### Instruction:
Are limited Depressive and Anxiety Symptoms Late in Pregnancy Related to Neonatal Outcomes?
### Response:
| Limited levels of prenatal depressive and anxiety symptoms do not seem to be associated with neonatal outcomes. In clinical practice, pregnant women, who suffer from low levels of prenatal depressive and anxiety symptoms, may be reassured, in respect of the adverse outcomes of these mood symptoms on the neonate. |
### Instruction:
Does down-regulation of osteopontin mediate a novel mechanism underlying the cytostatic activity of TGF-β?
### Response:
| Our results indicate that the OPN gene is a direct target of Smad-mediated TGF-β signaling, implying that OPN expression inhibition serves as a novel mechanism underlying the cytostatic activity of TGF-β. |
### Instruction:
Is an Anatomic Study on Whether the Immature Patella Centered on an Anteroposterior Radiograph?
### Response:
| The patella in an immature knee is rarely perfectly centered on a true AP image, and is usually seated slightly laterally within the femoral condyles. |
### Instruction:
Is pHF11 expression and cellular distribution regulated by the Toll-Like Receptor 3 Ligand Polyinosinic : Polycytidylic Acid in HaCaT keratinocytes?
### Response:
| In addition to a role for PHF11 in lymphocyte gene expression, we have now shown that PHF11 was part of the keratinocyte innate immune response by poly(I:C). As knock-down of PHF11 was associated with increased expression of the pro-inflammatory chemokine IL-8 and changes in the cellular distribution of claudin-1, a ch... |
### Instruction:
Does gABAergic Neurotransmission in the Premammillary Nucleus of the Turkey Hypothalamus regulate Reproductive Seasonality and the Onset of Photorefractoriness?
### Response:
| Consistent with the present findings, we propose that the long-sought-after mechanism underlying photorefractoriness is linked to the inhibitory actions of GABA. We suggest that (1) GABAergic interference with photoperiodic entrainment in the PMM initiates the photorefractory state and terminates the annual breeding se... |
### Instruction:
Does latent class analysis suggest four distinct classes of complementary medicine users among women with breast cancer?
### Response:
| LCA identified important subgroups of breast cancer patients characterized by varying degrees of complementary therapy use. Further research should explore the reproducibility of these classes and investigate the association between latent class membership and breast cancer outcomes. |
### Instruction:
Does haematocrit influence insulin concentration measurements in dried blood spots?
### Response:
| Haematocrit has a significant effect on insulin measurement by chemiluminescence when using DBS. Plasma insulin concentration could be determined when haematocrit was known. DBS insulin concentrations higher than plasma indicate that insulin may be present in red blood cells. However, measuring plasma insulin concentra... |
### Instruction:
Is carotid extramedial thickness associated with local arterial stiffness in children?
### Response:
| Carotid EMT is associated with the stiffness of the same arterial segment in children, suggesting that the arterial adventitia may be involved in early changes in arterial stiffness during childhood. |
### Instruction:
Does depletion of regulatory T-cells lead to moderate B-cell antigenicity in respiratory syncytial virus infection?
### Response:
| These results indicate that Tregs modulate B-cell activity, particularly in producing F-specific neutralizing antibodies, to regulate RSV-mediated exacerbated diseases. |
### Instruction:
Are five omic technologies concordant in differentiating the biochemical characteristics of the berries of five grapevine ( Vitis vinifera L. ) cultivars?
### Response:
| The five Omic technologies were consistent in distinguishing cultivar variation. There was high concordance between transcriptomic technologies, but generally protein abundance did not correlate well with transcript abundance. The integration of multiple high-throughput Omic datasets revealed complex biochemical variat... |
### Instruction:
Does amitriptyline and phenytoin prevent memory deficit in sciatic nerve ligation model of neuropathic pain?
### Response:
| The administration of amitriptyline and phenytoin can ameliorate neuronal injury, demyelination, and memory impairment associated with neuropathic pain in Wistar rats. |
### Instruction:
Does homeobox C9 suppress Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1?
### Response:
| Collectively, our data indicate that HOXC9 is an oncogene in glioblastoma. We have revealed its role in the control of autophagy, and we suggest that HOXC9 is a novel and promising therapeutic target. |
### Instruction:
Does iL7R gene expression network associate with human healthy ageing?
### Response:
| Overall, we conclude that the IL7R network reflected by gene expression levels in blood may be involved in the rate of ageing and health status of elderly individuals. |
### Instruction:
Does disruption of posteromedial large-scale neural communication predict recovery from coma?
### Response:
| In both etiology groups (traumatic and anoxic), changes in the connectivity of PCC-centered, spontaneously synchronized, large-scale networks account for the loss of external and internal self-centered awareness observed during coma. Sparing of functional connectivity between PCC and mPFC may predict patient outcome, a... |
### Instruction:
Are mitochondrial targeting sequence variants of the CHCHD2 gene a risk for Lewy body disorders?
### Response:
| Although the role of variants of the CHCHD2 gene in PD and LBD remains to be further elucidated, the rare variants in the mitochondrial targeting sequence may be a risk factor for Lewy body disorders, which may link CHCHD2 to other genetic forms of parkinsonism with mitochondrial dysfunction. |
### Instruction:
Does doxazosin Treatment attenuate Carbon Tetrachloride-Induced Liver Fibrosis in Hamsters through a Decrease in Transforming Growth Factor β Secretion?
### Response:
| Taken together, these results suggest that the decrease in collagen type I following treatment with doxazosin or carvedilol is achieved by decreasing the profibrotic activities of TGF-β via the blockage of α1- and β-adrenergic receptor. Consequently, a diminution of fibrotic tissue in the CCl4-induced model of cirrhosi... |
### Instruction:
Do paravertebral regional blocks decrease length of stay following surgery for pectus excavatum in children?
### Response:
| Our use of paravertebral continuous infusion pain catheters for pectus excavatum repair was an effective alternative to epidural analgesia resulting in shorter LOS but not a decrease in overall cost. |
### Instruction:
Are serum irisin levels lower in patients with breast cancer : association with disease diagnosis and tumor characteristics?
### Response:
| Our novel findings implicate irisin in breast cancer and suggest its potential application as a new diagnostic indicator of the presence of disease. |
### Instruction:
Is colonic Chicken Skin Mucosa an Independent Endoscopic Predictor of Advanced Colorectal Adenoma?
### Response:
| CSM-related adenoma was mainly found in the distal colon, and was associated with advanced pathology and multiple adenomas. CSM could be a potential predictive marker of the carcinogenetic progression of distally located colorectal adenomas. |
### Instruction:
Is lPL gene expression associated with poor prognosis in CLL and closely related to NOTCH1 mutations?
### Response:
| NOTCH1 mutations are tightly associated with LPL gene expression. LPL expression is independently associated with poor outcome in CLL and can be measured as a categorical variable. |
### Instruction:
Does stroke Location be an Independent Predictor of Cognitive Outcome?
### Response:
| Stroke location is an independent predictor of cognitive outcome (MoCA) at 3 months post stroke. |
### Instruction:
Do chemotherapy regimen checks performed by pharmacists contribute to safe administration of chemotherapy?
### Response:
| The computer could not evaluate chemotherapy protocols or adjust doses of anticancer medicines according to patients' conditions. Therefore, oncology pharmacists should continue to ensure safe and appropriate administration of cancer chemotherapy. |
### Instruction:
Are high levels of regulatory T cells in blood a poor prognostic factor in patients with diffuse large B-cell lymphoma?
### Response:
| Changes in blood immune cells occur in patients with DLBCL. The results also support a suppressive role of Tregs in adaptive immunity and correlate with poor-risk prognostic factors. |
### Instruction:
Does white Matter Abnormality correlate with Developmental and Seizure Outcomes in West Syndrome of Unknown Etiology?
### Response:
| Diffuse abnormal findings on DTI at 12 months of age suggest delayed myelination as a key factor underlying abnormal findings on DTI. Conversely, asymmetric abnormal findings on DTI at 24 months may reflect underlying focal pathologies. |
### Instruction:
Do high-visibility warning labels on paracetamol-containing products prevent supratherapeutic ingestion in a simulated scenario?
### Response:
| In this small, simulated dental pain scenario, use of customized warning labels did not reduce the likelihood of supratherapeutic misadventure. |
### Instruction:
Does remodeling of nuclear landscapes during human myelopoietic cell differentiation maintain co-aligned active and inactive nuclear compartments?
### Response:
| Our findings substantiate the conservation of the recently published ANC-INC network model of mammalian nuclear organization during human myelopoiesis irrespective of profound changes of the global nuclear architecture observed during this differentiation process. According to this model, two spatially co-aligned and f... |
### Instruction:
Is health-related quality of life unimpaired in children and adolescents with Marfan syndrome despite its distinctive phenotype?
### Response:
| QoL was fairly good in paediatric patients with MFS, and there was no impairment during adolescence. Despite the distinctive phenotype, quality of life was unimpaired in younger patients. |
### Instruction:
Is reduction of urgency severity the most important factor in the subjective therapeutic outcome of intravesical onabotulinumtoxinA injection for overactive bladder?
### Response:
| Subjectively successful treatment outcomes of intravesical onabotulinumtoxinA injection for OAB patients were associated with improvement in OAB symptoms but not increased bladder capacity. Neurourol. Urodynam. © 2015 Wiley Periodicals, Inc. |
### Instruction:
Do low Alpha-Fetoprotein Levels Are Associated with Improved Survival in Hepatocellular Carcinoma Patients with Portal Vein Thrombosis?
### Response:
| Patients with PVT are heterogeneous with respect to AFP levels. AFP-negative patients have a significantly better survival than those who have elevated AFP. |
### Instruction:
Is magnetic resonance elastography superior to acoustic radiation force impulse for the Diagnosis of fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease : A prospective study?
### Response:
| MRE is more accurate than ARFI for diagnosing any fibrosis in NAFLD patients, especially those who are obese. |
### Instruction:
Does preliminary Evidence suggest Periureteral Botulinum Toxin Type A Injection Improves Ureteral Stone Passage in the Porcine Model?
### Response:
| Preliminary results suggest that periureteral injection of BTX-A facilitates ureteral stone passage in this model. BTX-A may provide a simple, office-based endoscopic treatment option for ureteral stones. Further studies would be necessary to evaluate its efficacy in humans compared with traditional medical expulsive t... |
### Instruction:
Is hypoechogenicity of brainstem raphe nuclei associated with increased attack frequency in episodic migraine?
### Response:
| Sonographic findings did not differ between migraine patients and controls. Hypoechogenic BRN correlated to a higher migraine attack frequency, probably indicating more severe disease activity. |
### Instruction:
Do morphometric changes correlate with poor psychological outcomes in patients with acromegaly?
### Response:
| Our study demonstrates a correlation between physical changes associated with acromegaly and poor psychological outcomes, whereas no such correlation existed with modes of therapy, disease control status, RT, malignancy, initial or recent GH/IGF1 or secondary hormonal deficiency. Our data support the utility of the mor... |
### Instruction:
Is maternal hypothyroxinaemia in pregnancy associated with obesity and adverse maternal metabolic parameters?
### Response:
| Isolated hypothyroxinaemia, but not subclinical hypothyroidism, is associated with adverse metabolic phenotype in pregnancy, as is decreasing maternal FT4 and increasing FT3:FT4 ratio. These associations may be a reflection of changes in the thyroid hormone levels secondary to increase in BMI rather than changes in thy... |
### Instruction:
Does continuous renal replacement therapy in children : fluid overload always predict mortality?
### Response:
| In children treated with CRRT the underlying diagnosis and severity of illness are independent risk factors for mortality. The degree of FO is a negative predictor only in patients with milder disease. |
### Instruction:
Does intact Heart Loose Patch Photolysis reveal Ionic Current Kinetics During Ventricular Action Potentials?
### Response:
| The novel loose patch photolysis technique allowed the dissection of transmembrane ionic currents in the intact heart. We were able to determine that during an AP, L-type Ca(2+) current contributes to phase 1, whereas Na(+)-Ca(2+) exchanger contributes to phase 2. In addition, loose patch photolysis revealed that the i... |
### Instruction:
Is adherent perinephric fat at minimally invasive partial nephrectomy associated with adverse peri-operative outcomes and malignant renal histology?
### Response:
| Specific clinical and radiographic factors predict APF at MIPN. The presence of APF is associated with adverse peri-operative outcomes including longer operating time and greater EBL. APF was also associated with renal malignancy on final pathology, but further studies are necessary to elucidate the precise underlying ... |
### Instruction:
Do hemodiafiltration and hemodialysis differently affect P wave duration and dispersion on the surface electrocardiogram?
### Response:
| Our results suggest that HDF has a more beneficial effect on P wave duration and Pd than HD. The alterations in the ECG markers may be the result of the simultaneous occurrence of certain electrolyte imbalances and renal replacement methods. |
### Instruction:
Does iroquois homeobox 2 suppress cellular motility and chemokine expression in breast cancer cells?
### Response:
| Our results imply that the IRX2 transcription factor might represent a novel metastasis associated protein that acts as a negative regulator of cellular motility and as a repressor of chemokine expression. Loss of IRX2 expression could therefore contribute to early hematogenous dissemination of breast cancer by sustain... |
### Instruction:
Does global Longitudinal Strain be a Superior Predictor of All-Cause Mortality in Heart Failure With Reduced Ejection Fraction?
### Response:
| GLS is an independent predictor of all-cause mortality in HFrEF patients, especially in male patients without AF. Furthermore, GLS was a superior prognosticator compared with all other echocardiographic parameters. |
### Instruction:
Does quantitative Dual-Energy Computed Tomography support a Vascular Etiology of Smoking-induced Inflammatory Lung Disease?
### Response:
| These results demonstrate that sildenafil restores peripheral perfusion and reduces central arterial enlargement in normal SS subjects with little effect in NS subjects, highlighting DECT-PBV as a biomarker of reversible endothelial dysfunction in smokers with CAE. |
### Instruction:
Is lysine supplementation effective for the prevention or treatment of feline herpesvirus 1 infection in cats : a systematic review?
### Response:
| We recommend an immediate stop of lysine supplementation because of the complete lack of any scientific evidence for its efficacy. |
### Instruction:
Is a genetic risk score associated with polycystic ovary syndrome-related traits?
### Response:
| The GRS calculated by genome-wide association studies (GWASs) was significantly associated with PCOS status and its related clinical features. |
### Instruction:
Does senescence-Associated MCP-1 Secretion be Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells?
### Response:
| Senescence of UCB-MSCs is orchestrated by MCP-1, which is secreted as a major component of the SASP and is epigenetically regulated by BMI1. |
### Instruction:
Does simvastatin ameliorate experimental autoimmune encephalomyelitis by inhibiting Th1/Th17 response and cellular infiltration?
### Response:
| Simvastatin treatment promotes EAE clinical amelioration by inhibiting T cell proliferation and CNS infiltration by pathogenic Th1 and Th17 cells. |
### Instruction:
Does 5 Hz Repetitive Transcranial Magnetic Stimulation with Maximum Voluntary Muscle Contraction facilitate Cerebral Cortex Excitability of Normal Subjects?
### Response:
| Both 5 Hz rTMS and 5 Hz rTMS combined with MVC facilitate motor cortical excitability, but the enhancement in rTMS with MVC is more pronounced and maintained longer than simple rTMS. |
### Instruction:
Does genetic association analysis of miRNA SNPs implicate MIR145 in breast cancer susceptibility?
### Response:
| Our study is the first to report an association between a miR-SNP in MIR145 and breast cancer risk in individuals of Caucasian background. This finding requires further validation through genotyping of larger cohorts or in individuals of different ethnicities to determine the potential significance of this finding as w... |
### Instruction:
Is central arterial stiffness increased among subjects with severe and very severe COPD : report from a population-based cohort study?
### Response:
| GOLD 3-4, age ≥60, and CVD were associated with increased arterial stiffness, and also increased in COPD subjects with productive cough compared to those without. Of importance, GOLD 3-4 but not productive cough remained associated with increased central arterial stiffness when adjusted for confounders. |
### Instruction:
Are moisturizers effective in the treatment of xerosis irrespectively from their particular formulation : results from a prospective , randomized , double-blind controlled trial?
### Response:
| In the treatment of xerosis, consistent and regular moisturizer use is much more important than the moisturizer's particular formulation. |
### Instruction:
Does characterization of secretomes provide evidence for adipose-derived mesenchymal stromal cells subtypes?
### Response:
| Human ADSCs with CD90+/CD73+/CD105+/CD45-/CD31-/PDGFRβ+/NG2+/CD146+(-) immunophenotype secrete a large array of proteins, the most represented group is comprised of extracellular matrix components. Number of secreted proteins is largely unaffected by prolonged hypoxia. Variability in the secretion of several proteins f... |
### Instruction:
Does anti-CD163-dexamethasone protect against apoptosis after ischemia/reperfusion injuries in the rat liver?
### Response:
| We show that pharmacological preconditioning with anti-CD163-dex and high dose dexamethasone reduces the number of apoptotic cells following ischemia/reperfusion injury. |
### Instruction:
Does active FOXO1 be a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming?
### Response:
| This study indicates FOXO1 as a critical component for progesterone signaling to promote cellular senescence and reveals a novel mechanism for transcription factor control of hormone sensitivity. |
### Instruction:
Does early radiosurgery provide superior pain relief for trigeminal neuralgia patients?
### Response:
| Early SRS as the initial surgical procedure for management of refractory trigeminal neuralgia was associated with faster, better, and longer pain relief when compared to late SRS. |
### Instruction:
Does combined metabolome and transcriptome profiling provide new insights into diterpene biosynthesis in S. pomifera glandular trichomes?
### Response:
| Our work has uncovered the key enzymes involved in miltiradiene biosynthesis in S. pomifera leaf glandular trichomes. The transcriptomic dataset obtained provides a valuable tool for the identification of the CYPs involved in the synthesis of carnosic acid-family metabolites. |
### Instruction:
Does collagen application reduce complication rates of mid-substance ACL tears treated with dynamic intraligamentary stabilization?
### Response:
| A high complication rate following ACL Ligamys™ repair of mid-substance ruptures was noted. Application of a collagen membrane to the surface of the ACL resulted in a reduced incidence of extension deficit and re-ruptures. The results indicate that solitary ACL Ligamys™ repair does not present an appropriate treatment ... |
### Instruction:
Do diagnostic ultrasound estimates of muscle mass and muscle quality discriminate between women with and without sarcopenia?
### Response:
| Diagnostic ultrasound morphometry values are associated with LBM, and improve the BMI predictive model for aLM/ht(2) in women. In addition, ultrasound proxy measures of muscle quality are more strongly associated with strength than muscle mass within the study sample. |
### Instruction:
Are mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Conserved in Canine Mast Cell Tumors?
### Response:
| Results obtained in this preliminary study are suggestive of a substantial difference between human SM and canine MCT if we consider some target genes known to be involved in the pathogenesis of human SM. |
### Instruction:
Is [ Body mass index a risk factor for new-onset non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus ]?
### Response:
| Risk of NAFLD in T2DM patients increases in parallel to increase in weight assessed by BMI. BMI appeared to be an independent risk factor for NAFLD. |
### Instruction:
Does microRNA-148a suppress Invasion and Metastasis of Human Non-Small-Cell Lung Cancer?
### Response:
| Evidence from this study demonstrated that miR-148a exerts tumor-suppressive effects in NSCLC and suggests a new therapeutic option for NSCLC. |
### Instruction:
Does cardiomyocyte VEGF regulate Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus?
### Response:
| EC, as the first responders to hyperglycemia, can release heparanase to liberate myocyte VEGF. This growth factor, by activating EC Notch signaling, is responsible for facilitating GPIHBP1-mediated translocation of LPL across EC and regulating LPL-derived fatty acid delivery to the cardiomyocytes. |
### Instruction:
Does deletion of Hyaluronan Synthase 3 inhibit Neointimal Hyperplasia in Mice?
### Response:
| HAS3-mediated HA synthesis after vessel injury supports seminal signaling pathways in activation of VSMC, increases platelet-derived growth factor BB-mediated migration, and in turn enhances neointimal hyperplasia in vivo. |
### Instruction:
Is hepatic DNA hydroxymethylation site-specifically altered by chronic alcohol consumption and aging?
### Response:
| These results suggest that the location of hydroxymethylcytosine in the genome is site specific and not random, and that changes in hydroxymethylation may play a role in the liver's response to aging and alcohol. |
### Instruction:
Are bMI and season associated with vitamin D deficiency in women with impaired fertility : a two-centre analysis?
### Response:
| The rate of vitamin D deficiency among women with impaired fertility is alarming. Prospective studies are pressingly needed to confirm a causal relationship and to investigate the potential therapeutic benefits of vitamin D supplementation in this population. |
### Instruction:
Does transcriptome-wide functional characterization reveal novel relationships among differentially expressed transcripts in developing soybean embryos?
### Response:
| This work demonstrates how our integrated framework can be implemented to make experimentally testable predictions regarding the coding potential, co-expression, co-regulation, and function of transcripts and proteins related to a biological process of interest. |
### Instruction:
Does the combination of four molecular markers improve thyroid cancer cytologic diagnosis and patient management?
### Response:
| The four genes model proposed in this study proved to be highly discriminative of the malignant status compared with BRAF assessment alone. Its implementation in clinical practice can help in identifying malignant/benign nodules that would otherwise remain suspicious. |
### Instruction:
Does smaller size of high metabolic rate organs explain lower resting energy expenditure in Asian-Indian Than Chinese men?
### Response:
| We have demonstrated a lower REE in Asian-Indians compared with Chinese who may contribute to the higher rates of obesity in the former. This difference could be accounted for by differences in metabolically active organs. |
### Instruction:
Does helicobacter pylori Eradication prevent Metachronous Gastric Neoplasms after Endoscopic Resection of Gastric Dysplasia?
### Response:
| Successful H. pylori eradication may reduce the development of metachronous gastric neoplasms after ER in patients with gastric dysplasia. |
### Instruction:
Is metabolomic fingerprint of severe obesity dynamically affected by bariatric surgery in a procedure-dependent manner?
### Response:
| Our data indicate that bariatric surgery, irrespective of the specific kind of procedure used, reverses most of the metabolic alterations associated with obesity and suggest profound changes in gut microbiome-host interactions after the surgery. This trial was registered at clinicaltrials.gov as NCT02480322. |
### Instruction:
Does endogenous IFN-β signaling exert anti-inflammatory actions in experimentally induced focal cerebral ischemia?
### Response:
| We conclude that endogenous IFN-β signaling attenuates local inflammation, regulates peripheral immune cells, and, thereby, may contribute positively to stroke outcome. |
### Instruction:
Do glucocorticoids impair bone formation of bone marrow stromal stem cells by reciprocally regulating microRNA-34a-5p?
### Response:
| These results showed that microRNA-34a-5p, a crucial regulator for BMSC proliferation and osteogenic differentiation, might be used as a therapeutic target for GC-impaired bone formation. |
### Instruction:
Do common variants in LEPR , IL6 , AMD1 , and NAMPT associate with risk of juvenile and childhood obesity in Danes : a case-control study?
### Response:
| The IL6, LEPR, NAMPT, and AMD1 gene variants previously found to associate among Indian children did not associate with risk of obesity or obesity-related quantitative measures among Caucasian children and juvenile men from Denmark. |
### Instruction:
Do a comparison of arthroscopy to ultrasonography for identification of pathology of the equine stifle?
### Response:
| Ultrasonography and arthroscopy should be combined to best evaluate pathology of the stifle, since each modality has its own limitations depending on the location and type of lesion. |
### Instruction:
Does tAT-peroxiredoxin 2 Fusion Protein Supplementation improve Sperm Motility and DNA Integrity in Sperm Samples from Asthenozoospermic Men?
### Response:
| This study shows that supplementation of TAT-peroxiredoxin 2 fusion protein in the sperm suspension from asthenozoospermic men effectively improved sperm motility and DNA integrity by reducing levels of reactive oxygen species. Therefore, we speculate that peroxiredoxin 2 may have an important role as an antioxidant de... |
### Instruction:
Does doxycycline inhibit TGF-β1-induced extracellular matrix production in nasal polyp-derived fibroblasts?
### Response:
| Doxycycline has an inhibitory effect on TGF-β1-induced myofibroblast differentiation and extracellular matrix production via the p38 and JNK/NF-κB signal pathways in NPDFs. |
### Instruction:
Does pretreatment of parecoxib attenuate hepatic ischemia/reperfusion injury in rats?
### Response:
| Administration of parecoxib prior to hepatic I/R attenuates hepatic injury through inhibition of inflammatory response and nitrosative stress. |
### Instruction:
Does ezetimibe attenuate Atherosclerosis Associated with Lipid Reduction and Inflammation Inhibition?
### Response:
| Ezetimibe alone played the same protection against a moderate atherosclerotic lesion as atorvastatin, which was associated with lowering serum cholesterol, decreasing circulating inflammatory cytokines, and inhibiting macrophage accumulation in the lesions. |
### Instruction:
Is the 11q Terminal Deletion Disorder Jacobsen Syndrome a Syndromic Primary Immunodeficiency?
### Response:
| Most patients with JS suffer from combined immunodeficiency in the presence of recurrent infections. Therefore, we consider JS a syndromic primary immunodeficiency. Early detection of immunodeficiency may reduce the frequency and severity of infections. All JS patients should therefore undergo immunological evaluation.... |
### Instruction:
Does cD36 be a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal During Cardiac Remodeling?
### Response:
| Our data reveal a new cell-signaling role for MMP-9 through CD36 degradation to regulate macrophage phagocytosis and neutrophil apoptosis. |
### Instruction:
Is miR-21 required for efficient kidney regeneration in fish?
### Response:
| In summary, our findings extend the role of miR-21 in the kidney. For the first time we show its functional involvement in regeneration indicating that fast proliferation and reduced apoptosis are important for efficient renal tubular regeneration. |
### Instruction:
Does miR-490-5p suppress tumour growth in renal cell carcinoma through targeting PIK3CA?
### Response:
| Taken together, our results indicated for the first time that miR-490-5p functions as a tumour suppressor in renal carcinoma by targeting PIK3CA. |
### Instruction:
Does fetal Stomach Position predict Neonatal Outcomes in Isolated Left-Sided Congenital Diaphragmatic Hernia?
### Response:
| Fetal stomach position is strongly associated with neonatal outcomes in isolated left CDH. This objective tool may allow for accurate prognostication in a variety of clinical settings. |
### Instruction:
Does stimulation with bone morphogenetic protein-2 ( BMP-2 ) enhance bone-tendon integration in vitro?
### Response:
| Exposure to BMP-2 upregulated the expression of genes associated with bone-tendon integration in vitro, suggesting the stimulation of transdifferentiation processes at the interface and fibroblast regions as well as the induction of positive feedback mechanisms. Further studies will be needed to establish BMP-2 dose an... |
### Instruction:
Do symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis?
### Response:
| In patients with EoE, endoscopic or histologic remission can be identified with only modest accuracy based on symptoms alone. At any given time, physicians cannot rely on lack of symptoms to make assumptions about lack of biologic disease activity in adults with EoE. ClinicalTrials.gov, Number: NCT00939263. |
### Instruction:
Does early language mediate the relations between preschool inattention and school-age reading achievement?
### Response:
| Early attentional deficits may negatively impact school-age reading outcomes by compromising the development of language skills, which in turn imperils later reading achievement. Screening children with attentional problems for language impairment, as well as implementing early intervention for both attentional and lan... |
### Instruction:
Does ethanol consumption produce a small increase in circulating miR-122 in healthy individuals?
### Response:
| miR-122 increased with moderate ethanol consumption, but the fold change was modest. As increases with acetaminophen toxicity are 100- to 10 000-fold, moderate ethanol intoxication is unlikely to confound the use of this biomarker of hepatotoxicity. |
### Instruction:
Does dNA repair gene ERCC1 C118T polymorphism predict sensitivity of recurrent esophageal cancer to radiochemotherapy in a Chinese population?
### Response:
| ERCC1 C118T could be a predictive factor for the response to radiotherapy and chemotherapy, but not a prognostic factor for OS in esophageal cancer patients after surgery. |
### Instruction:
Are anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells mediated by TRPV1 and TRPA1 in a COX-2 dependent manner?
### Response:
| N-acylethanolamines exert anti-inflammatory effects in SFs. A dual FAAH/COX-2 inhibitor, increasing N-acylethanolamine levels with concomitant TRP channel desensitization, might be a good candidate to inhibit the production of proinflammatory mediators of synovial cells and to reduce erosions. |
### Instruction:
Do integrated genomics approach to identify biologically relevant alterations in fewer samples?
### Response:
| In overall, we present the first comprehensive genomic characterization of four head and neck cancer cell lines established from Indian patients. We also demonstrate the ability of integrated analysis to uncover biologically important genetic variation in studies involving fewer or rare clinical specimens. |
### Instruction:
Does fK506 reduce albuminuria through improving podocyte nephrin and podocin expression in diabetic rats?
### Response:
| Our results show that FK506 not only upregulates expression of nephrin and podocin but also inhibits macrophage activation to protect against podocyte injury. |
### Instruction:
Does orally administered extract from Prunella vulgaris attenuate spontaneous colitis in mdr1a ( -/- ) mice?
### Response:
| The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a(-/-) mice. |
### Instruction:
Is bile acid elevation after Roux-en-Y gastric bypass associated with cardio-protective effect in Zucker Diabetic Fatty rats?
### Response:
| Based on these findings, RYGB showed beneficial effect on aortic wall thickness, possibly through bile acids and L-PGDS elevation in a severely obese and diabetic rodent model. |
### Instruction:
Does reduced Bone Mineral Density be Associated with Celiac Disease Autoimmunity in Children with Type 1 Diabetes?
### Response:
| The results suggest a synergistic effect of hyperglycemia and celiac autoimmunity on low BMD. |
### Instruction:
Is not all the number of skeletal muscle fibers determined prenatally?
### Response:
| Our results highlight different development time frames of anatomically distinct skeletal muscles. |
### Instruction:
Does intermittent Dosing of Micafungin be Effective for Treatment of Experimental Disseminated Candidiasis in Persistently Neutropenic Rabbits?
### Response:
| Less fractionated MFG regimens of every 48 and 72 hours are safe and as effective in experimental disseminated candidiasis as once-daily therapy in neutropenic hosts. |
### Instruction:
Do species-specific modifications of mandible shape reveal independent mechanisms for growth and initiation of the coronoid?
### Response:
| The mandibular coronoid process is initiated by intrinsic factors, but later growth is dependent on extrinsic signals from the muscle. These extrinsic influences are hypothesised to be the basis of the variation in coronoid length seen across the mammalian lineage. |
### Instruction:
Does analytical approach for lipidomics and its potential applications in neuropsychiatric disorders?
### Response:
| This review highlights the importance of lipidomics for the future perspectives as a tool for biomarker identification and discovery and its clinical application. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.