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### Instruction:
Does cerebrospinal Fluid Biomarker for Alzheimer Disease predict Postoperative Cognitive Dysfunction?
### Response:
| Low CSF Aβ1-42 may be a significant predictor of POCD at 3 months. This indicates that patients with AD neuropathology even in the absence of clinically detectable AD symptoms may be susceptible to POCD. |
### Instruction:
Do low Vitamin D Levels Are Associated With an Adverse Clinical Outcome in Febrile Neutropenia?
### Response:
| A high prevalence of vitamin D deficiency was observed in patients with febrile neutropenia. Low levels were associated with an adverse clinical outcome. |
### Instruction:
Is markedly High Plasma Thrombopoietin ( TPO ) Level a Predictor of Poor Response to Immunosuppressive Therapy in Children With Acquired Severe Aplastic Anemia?
### Response:
| The measurement of TPO levels at diagnosis is useful for predicting the response to IST in children with SAA and may help in decision making. |
### Instruction:
Do cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib?
### Response:
| Evacetrapib, as monotherapy and combined with statins, not only increased total CEC, but also increased ABCA1-specific CEC and pre-beta-1 HDL. The mechanisms by which potent CETP inhibition increases ABCA1-specific CEC and pre-beta-1 HDL require further study. (A Study of LY2484595 in Patients With High LDL-C or Low HD... |
### Instruction:
Does the Minor Allele of rs7574865 in the STAT4 Gene be Associated with Increased mRNA and Protein Expression?
### Response:
| Our data suggest that the presence of the rs7574865 T allele enhances STAT4 mRNA transcription and protein expression. It may enhance the signaling of molecules depending on the STAT4 pathway. |
### Instruction:
Is platelet aggregation in response to ADP highly variable in normal donors and patients on anti-platelet medication?
### Response:
| The results of our study demonstrate that 15% of normal donors and 38% of patients taking aspirin only would be classified as having a therapeutic response to P2Y12 inhibition using current guidelines. |
### Instruction:
Does injection of Human Cord Blood Cells With Hyaluronan improve Postinfarction Cardiac Repair in Pigs?
### Response:
| This study using healthy human cord blood mononuclear cells (CB-MNCs) to treat myocardial infarction provides preclinical evidence that combined injection of hyaluronan and human CB-MNCs after myocardial infarction significantly increases cell retention in the peri-infarct area, improves cardiac performance, and preven... |
### Instruction:
Does therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduce diabetic cardiomyopathy?
### Response:
| Therapeutic inhibition of mitochondrial ROS by mito-TEMPO reduced adverse cardiac changes and mitigated myocardial dysfunction in diabetic mice. Thus, mitochondria-targeted antioxidants may be an effective therapy for diabetic cardiac complications. |
### Instruction:
Is fXR expression associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity?
### Response:
| Maternal obesity influences renal expression of pro-inflammatory and fibrotic factors that predispose the offspring to CKD. This was associated with the downregulation of the renal FXR expression suggesting a potential protective role for FXR. |
### Instruction:
Are alzheimer 's disease cerebrospinal fluid biomarkers influenced by gravity drip or aspiration extraction methodology?
### Response:
| Our results demonstrate that aspiration of CSF is comparable to gravity droplet collection for AD biomarker analyses but could considerably accelerate throughput and improve the procedural tolerability for assessment of CSF biomarkers. |
### Instruction:
Do combined pars plana vitrectomy and Baerveldt glaucoma implant placement for refractory glaucoma?
### Response:
| PPV-BGI is a viable surgical option for eyes with refractory glaucoma, but visual outcomes are frequently poor because of ocular comorbidities, especially in eyes with NVG. The location of tube placement does not influence surgical outcome and should be left to the discretion of the surgeon. |
### Instruction:
Is a photodynamic therapy combined with topical 5-aminolevulinic acid and systemic hematoporphyrin derivative more efficient but less phototoxic for cancer?
### Response:
| The combined PDT not only shows high cure rate for skin cancers but also decreases the dose of the pro-toxic HPD and significantly shortens the photosensitive period, from which the patients are able to benefit. |
### Instruction:
Is upregulation of EGFR signaling correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer?
### Response:
| These studies have revealed a correlation between tumor recurrence and changes of stromal microenvironment accompanied by altered EGFR signaling. |
### Instruction:
Do genomics and transcriptomics of Xanthomonas campestris species challenge the concept of core type III effectome?
### Response:
| This dataset is an important resource to mine for novel type III effector proteins as well as for bacterial genes which could contribute to pathogenicity of X. campestris. |
### Instruction:
Does transcriptome profiling reveal distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse?
### Response:
| Our results indicate the significance of retinol signalling and neonatal transcriptomic relics as the distinguishing features of the MRL/MpJ mouse. The possibility that retinoids could act as key regulatory molecules in this regeneration model brings important implications for regenerative medicine. |
### Instruction:
Does squid ink polysaccharide reduce cyclophosphamide-induced testicular damage via Nrf2/ARE activation pathway in mice?
### Response:
| These results suggest that SIP could effectively weaken CP-associated testicular damage via Nrf2/ARE signal pathway. |
### Instruction:
Does sphingosine 1-phosphate interact with Survivin pathway to enhance tumorigenesis in cancer cells?
### Response:
| Our results confirmed the involvement of S1P and its receptors in tumor progression of SKW3 and H1299. We also investigated another mechanism of S1P involved in cell survival, tumor progression, and Survivin signaling. In conclusion, data demonstrated the importance of this molecule as a target for designing new antica... |
### Instruction:
Is increasing maternal obesity associated with alterations in both maternal and neonatal thyroid hormone levels?
### Response:
| Maternal obesity is not only associated with maternal alterations in TH, but with accompanying neonatal changes. Because both maternal obesity and alterations in TH levels are associated with childhood obesity, based on these findings and our prior analyses in a nonhuman primate model, we propose that changes in fT3 le... |
### Instruction:
Does hypomethylation of TET2 Target Genes identify a Curable Subset of Acute Myeloid Leukemia?
### Response:
| Low levels of tet2-DMC methylation define a subgroup of AML that is highly curable and cannot be identified solely by genetic and cytogenetic analyses. |
### Instruction:
Does high-Intensity Signal in Carotid Plaque on Routine 3D-TOF-MRA be a Risk Factor of Ischemic Stroke?
### Response:
| HIS in carotid plaques on 3D-TOF-MRA MIP images are independent determinants of prior ischemic strokes in patients with moderate carotid artery stenosis, and they can potentially provide a reliable risk stratification of patients with moderate carotid artery stenosis. |
### Instruction:
Is membranous CD24 expression as detected by the monoclonal antibody SWA11 a prognostic marker in non-small cell lung cancer patients?
### Response:
| Membranous CD24 immunoreactivity, as detected with antibody clone SWA11 may serve as a prognostic factor for lymphonodular spread and poorer overall survival. Furthermore, these results corroborate the importance of a careful distinction between membranous and cytoplasmic localisation, if CD24 is to be considered as a ... |
### Instruction:
Do `` Why We Say No ! A Look Through the Editor 's Eye ''?
### Response:
| Based on our findings, it can be concluded that manuscript rejection can be avoided by the authors, if the topic is well choosen and communication is maintained with the journal editorial. |
### Instruction:
Is distant Metastasis in Colorectal Cancer a Risk Factor for Anastomotic Leakage?
### Response:
| Patients with stage IV colorectal cancer have an increased anastomotic leak rate after colorectal surgery. Whether this is due to an impaired immune system remains speculative. |
### Instruction:
Does signal recognition particle immunoglobulin g detected incidentally associate with autoimmune myopathy?
### Response:
| Autoimmune necrotizing SRP myopathy, both idiopathic and paraneoplastic, is underdiagnosed in neurological practice. Serological screening aids early diagnosis. Cancer surveillance and appropriate immunosuppressant therapy may improve outcome. Muscle Nerve 53: 925-932, 2016. |
### Instruction:
Does baseline HV-interval predict complete AV-block secondary to transcatheter aortic valve implantation?
### Response:
| HV-interval was prolonged in approximately one third of our elderly patients with aortic valve stenosis and associated with a high rate of complete AV-block following TAVI. HV-interval is easily obtained during TAVI screening procedures, thus facilitating identification of patients at risk for complete AV-block due to ... |
### Instruction:
Does nGF modulate trkANGFR/p75NTR in αSMA-Expressing Conjunctival Fibroblasts from Human Ocular Cicatricial Pemphigoid ( OCP )?
### Response:
| Taken together, these data are suggestive for a NGF/p75NTR task in the potential modulation of OCP fibrosis and encourages further studies to fully understand the underlying mechanism occurring in fibrosis. NGF/p75NTR might be viewed as a potential therapeutic target. |
### Instruction:
Is higher intrinsic network excitability in ventral compared with the dorsal hippocampus controlled less effectively by GABAB receptors?
### Response:
| These results demonstrate a higher intrinsic neuronal excitability of the ventral compared with the dorsal local circuitry with the considerable contribution of NMDA receptors. Furthermore, the GABA(B) receptors control the total and the NMDA receptor-dependent excitation much less effectively in the ventral part of th... |
### Instruction:
Do systematic reviews experience major limitations in reporting absolute effects?
### Response:
| Most SRs do not report absolute effects. Those that do often report them inadequately, thus requiring users of SRs to generate their own estimates of absolute effects. For any apparently effective or harmful intervention, SR authors should report both absolute and relative estimates to optimize the interpretation of th... |
### Instruction:
Does self-Reported Sleep Disturbance mediate the Relationship Between PTSD and Cognitive Outcome in Blast-Exposed OEF/OIF Veterans?
### Response:
| Our results highlight the importance of sleep disturbance as a factor contributing to cognitive outcome in individuals with posttraumatic stress disorder symptoms. They point to the importance of considering sleep problems in the diagnosis and treatment of cognitive deficits in veterans with blast exposure. |
### Instruction:
Does deferoxamine stimulate LDLR expression and LDL uptake in HepG2 cells?
### Response:
| DFO induced an increase in LDLR expression by a posttranscriptional mechanism resulting in an enhancement of LDL uptake in HepG2 cells, suggesting increased LDLR activity as one of the underlying causes of the hypocholesterolemic effect of iron reduction. |
### Instruction:
Do vestibular-evoked myogenic potentials before and after dental implant surgery?
### Response:
| The present study revealed a significant difference in the cervical VEMP response on the second postoperative day for p1 and n1 latencies compared to the baseline and seventh postoperative day in dental implantation patients. Dental implant patients should be informed of such possible temporary problems as dizziness an... |
### Instruction:
Does n-acetylcysteine attenuate cigaret smoke-induced pulmonary exacerbation in a mouse model of emphysema?
### Response:
| Exposure of mice with emphysema to CS exacerbated the pulmonary damage, and NAC reduced the CS-mediated pulmonary damage by preventing oxidative damage and reducing inflammatory responses. |
### Instruction:
Does activation of the hip adductor muscles vary during a simulated weight-bearing task?
### Response:
| Adductor magnus and adductor longus muscles are recruited to different extents during a simulated weight-bearing task. This information should be considered when selecting exercises for management and prevention of groin strains. Closed chain exercises with weight-bearing through the lower limb are more likely to recru... |
### Instruction:
Are impaired sustained attention and lapses present in patients with mild obstructive sleep apnea?
### Response:
| Patients with mild OSA showed increased sustained attention lapses compared with normal subjects. |
### Instruction:
Does miR-449a targets Flot2 and inhibit gastric cancer invasion by inhibiting TGF-β-mediated EMT?
### Response:
| Our results demonstrated that miR-449a suppressed Flot2 expression results in decreased cell invasion through repressing TGF-β-mediated-EMT, and provides a new theoretical basis to further investigate miR-449a-regulated Flot2 as a potential biomarker and a promising approach for GC treatment. |
### Instruction:
Is anisotropy of Solid Breast Lesions in 2D Shear Wave Elastography an Indicator of Malignancy?
### Response:
| Anisotropy may be useful during benign/malignant differentiation of solid breast masses using SWE. Anisotropy also correlates with some prognostic factors in breast cancer. |
### Instruction:
Does airway β-Defensin-1 Protein be Elevated in COPD and Severe Asthma?
### Response:
| Elevated β-defensin-1 protein is a feature of COPD and severe asthma regardless of inflammatory phenotype. β-defensin-1 production is dysregulated in the epithelium of patients with COPD and may be an effective biomarker and potential therapeutic target. |
### Instruction:
Does small interfering RNA targeting PGC-1α inhibit VEGF expression and tube formation in human retinal vascular endothelial cells?
### Response:
| Blocking PGC-1α expression can inhibit VEGF expression in hRVECs and inhibit their ability to form tubes under both normoxic and hypoxic conditions. |
### Instruction:
Does protein tyrosine phosphatase 1B regulate migration of ARPE-19 cells through EGFR/ERK signaling pathway?
### Response:
| PTP1B inhibition promoted myofibroblast differentiation and migration of ARPE-19 cells, and EGFR/ERK signaling pathway played important role in migration process. |
### Instruction:
Does transgenic expression of omega-3 PUFA synthesis genes improve zebrafish survival during Vibrio vulnificus infection?
### Response:
| Fadsd6 and Elvol5a transgenic zebrafish are more resistant to V. vulnificus infection, and enhance survival by diminishing the attendant inflammatory response. |
### Instruction:
Does stachyose increase absorption and hepatoprotective effect of tea polyphenols in high fructose-fed mice?
### Response:
| Our results suggest that stachyose enhances absorption and hepatoprotective effects of TP, and combined ingestion of stachyose and TP is a novel strategy for alleviating HF diet-induced hepatic injury. |
### Instruction:
Do procalcitonin levels predict infectious complications and response to treatment in patients undergoing cytoreductive surgery for peritoneal malignancy?
### Response:
| PCT, like WCC and CRP, needs to be interpreted with extreme cautions in the context of infections post-cytoreductive-surgery and should only be used in association with other clinical and investigational findings. |
### Instruction:
Is fold stability during endolysosomal acidification a key factor for allergenicity and immunogenicity of the major birch pollen allergen?
### Response:
| Our data indicate that differential pH-dependent fold stability along endosomal maturation is an essential protein-inherent determinant of allergenicity. |
### Instruction:
Does nADPH oxidase 4 protect against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice?
### Response:
| Nox4 plays an important role in maintaining endothelial function under physiological and pathological conditions. Loss of Nox4-derived H2O2 could be partially compensated for by nNOS upregulation, but severe endothelial dysfunction is not reversible. This leads to increased atherosclerosis under atherosclerotic prone c... |
### Instruction:
Is a Carbohydrate Sulfotransferase-6 ( CHST6 ) gene mutation associated with Macular Corneal Dystrophy in Labrador Retrievers?
### Response:
| A missense mutation in the CHST6 gene is strongly associated with autosomal recessive MCD in the LR. |
### Instruction:
Does optimization of an automated be addition system for use in high-throughput quantitative DBS analysis?
### Response:
| LC-MS/MS method validations across four representative small molecule assays using the optimized IS spray conditions were demonstrated to produce analytical performance comparable to conventional methods of IS addition, demonstrating that the spray technique is a viable alternative. |
### Instruction:
Does bK Channel β1 Subunit contribute to Behavioral Adaptations Elicited by Chronic Intermittent Ethanol Exposure?
### Response:
| Altogether, the present findings reveal the critical role of BK β1 in behavioral adaptations to prolonged, repeated EtOH intoxication. |
### Instruction:
Does quantitative and qualitative trophectoderm grading allow for prediction of live birth and gender?
### Response:
| The presented correlation of TE with outcome indicates that TE scoring could replace ICM scoring in terms of priority. This would automatically require a rethinking process in terms of blastocyst selection and cryopreservation strategy. |
### Instruction:
Does a Novel Immune Marker Model predict Oncological Outcomes of Patients with Colorectal Cancer?
### Response:
| The in situ immune marker model constructed in this study provides a novel approach to identify CRC patients who were at an increased risk for poor oncological outcomes. |
### Instruction:
Are maternal obesity and gestational weight gain risk factors for infant death?
### Response:
| Interventions aimed at substantially reducing preconception weight among women with obesity and avoiding very low or very high gestational weight gain may reduce risk of infant death. |
### Instruction:
Does early HIV RNA decay during raltegravir-containing regimens exhibit two distinct subphases ( 1a and 1b )?
### Response:
| We found that the first phase of viral decay with RAL therapy was composed of two subphases corresponding to the half-lives of infected cells with integrated proviruses and with unintegrated HIV-DNA. |
### Instruction:
Does rapid skeletal muscle wasting predict worse survival in patients with liver cirrhosis?
### Response:
| ΔSMA/y is useful for predicting mortality in patients with liver cirrhosis. Management of skeletal muscle may contribute toward improving the outcome of cirrhotic patients. |
### Instruction:
Is spring season birth associated with higher emergency department admission for acute allergic reactions?
### Response:
| Patients born in spring appear particularly vulnerable to allergic reactions requiring ED visit. |
### Instruction:
Does peripheral Blood Mononuclear Cell Gene Expression remain Broadly Altered Years after Successful Interferon-Based Hepatitis C Virus Treatment?
### Response:
| PBMC inflammatory gene expression patterns in SVR resemble NR more than SC patients. A generalized inflammatory response persists in PBMCs long after successful peg-IFN treatment for HCV infection. |
### Instruction:
Are cSF IgA NMDAR antibodies potential biomarkers for teratomas in anti-NMDAR encephalitis?
### Response:
| These results suggest that in patients with IgG-NMDAR-Ab encephalitis, CSF IgA-NMDAR-Abs could be used as a biological marker for the presence of an ovarian teratoma. |
### Instruction:
Does estrogen treatment enhance neurogenic differentiation of human adipose derived stem cells in vitro?
### Response:
| According to our findings, estrogen can promote proliferation and neuronal differentiation of human ADSCs. |
### Instruction:
Do calcineurin Inhibitors Downregulate HNF-1β and May Affect the Outcome of HNF1B Patients After Renal Transplantation?
### Response:
| Because HNF1B-related disease is a heterozygous condition, CNIs used to prevent rejection may induce reduced expression of the nonmutated allele of HNF1B leading to a superimposed defect of HNF-1β transcriptional activity. Taking into account the specific risk of posttransplantation diabetes mellitus and liver disorder... |
### Instruction:
Does miR-27b-3p suppress cell proliferation through targeting receptor tyrosine kinase like orphan receptor 1 in gastric cancer?
### Response:
| These results show that miR-27b-3p suppresses ROR1 expression through the binding site in the 3'UTR inhibiting the cell proliferation. These findings indicate that miR-27b-3p exerts tumor-suppressive effects in GC through the suppression of oncogene ROR1 expression and suggest a therapeutic application of miR-27b-3p in... |
### Instruction:
Is lower birth weight associated with alterations in dietary intake in adolescents independent of genetic factors : A twin study?
### Response:
| Lower birth weight was related with higher intake of energy and saturated fat within twin pairs, and these associations were independent of zygosity, suggesting that the association between birth weight and alterations in dietary intake in later life is explained by intrauterine environmental rather than genetic factor... |
### Instruction:
Does high Dietary Sodium Intake Assessed by Estimated 24-h Urinary Sodium Excretion be Associated with NAFLD and Hepatic Fibrosis?
### Response:
| High sodium intake was independently associated with an increased risk of NAFLD and advanced liver fibrosis. |
### Instruction:
Is rapid metabolizer genotype of CYP2C19 a risk factor of being refractory to proton pump inhibitor therapy for reflux esophagitis?
### Response:
| The present meta-analysis demonstrates that CYP2C19 RMs with RE have an increased risk of being refractory to PPI therapy compared with PMs. Individualized dosing regimen with PPIs based on CYP2C19 genotype might be a valid therapeutic strategy for overcoming insufficient gastric acid inhibition. |
### Instruction:
Does lowering Uric Acid With Allopurinol improve Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia?
### Response:
| Allopurinol lowers uric acid and improves insulin resistance and systemic inflammation in asymptomatic hyperuricemia. Larger clinical trials are recommended to determine if lowering uric acid can help prevent type 2 diabetes. |
### Instruction:
Is sATB1 a potential therapeutic target in intrahepatic cholangiocarcinoma?
### Response:
| Our results highlight the significance of SATB1 in ICC and suggest that SATB1 could be a promising therapy target and a potential biomarker for prognosis in ICC patients. |
### Instruction:
Do microRNAs relate to early worsening of renal function in patients with acute heart failure?
### Response:
| Our results show that the levels of circulating miRNAs at hospital admission for acute HF were consistently lower in patients who developed worsening of renal function. MiR-199a-3p was the best predictor of WRF in these patients. |
### Instruction:
Does endocardial Endothelial Dysfunction Progressively disrupt Initially Anti then Pro-Thrombotic Pathways in Heart Failure Mice?
### Response:
| CREBA133 mice develop HF and endocardial endothelial dysfunction. Attenuation of the anti-coagulant APC pathway promotes endocardial thrombosis in early and acute decompensated phases of HF. However, in stable compensated HF mice, disruptions in endothelial vWF expression and extrusion may actually reduce the incidence... |
### Instruction:
Does social Network Analysis reveal the Negative Effects of Attention-Deficit/Hyperactivity Disorder ( ADHD ) Symptoms on Friend-Based Student Networks?
### Response:
| Our findings suggest that the severity of ADHD symptoms is strongly correlated with the quality of social and interpersonal relationships in students with ADHD symptoms. |
### Instruction:
Are antidepressants overprescribed for mild depression?
### Response:
| In these health systems, prescribing of antidepressant medication for minimal or mild depression is much less common than suggested by previous reports. Given that this practice may sometimes be clinically appropriate, our findings indicate that overprescribing of antidepressants for mild depression is not a significan... |
### Instruction:
Do deficiencies in the health care system contribute to a high rate of late HIV diagnosis in Sweden?
### Response:
| Deficiencies in the health care system with missed HIV testing opportunities contribute to the high proportion of late presenters in Sweden, especially among migrants. With increased testing at immigration and further incorporation of "indicator-guided" testing in general practice, most patients could be diagnosed earl... |
### Instruction:
Are monocyte unresponsiveness and impaired IL1β , TNFα and IL7 production associated with a poor outcome in Malawian adults with pulmonary tuberculosis?
### Response:
| Dysregulated monocyte cytokine production was identified in TB patients with poor outcome. Lower TNFα responses to H37Rv paralleled lower responses to a panel of TLR ligands, suggesting an underlying perturbation in common TLR signalling pathways. Future work should explore the role of TLR polymorphisms in immune respo... |
### Instruction:
Does tanezumab reduce Pain in Women with Interstitial Cystitis/Bladder Pain Syndrome and Patients with Nonurological Associated Somatic Syndromes?
### Response:
| Women with interstitial cystitis/bladder pain syndrome and patients with symptoms suggesting the concomitant presence of nonurological associated somatic syndromes were more likely to experience significant pain reduction with tanezumab than with placebo therapy. In contrast, no difference was reported in response betw... |
### Instruction:
Does atherosclerosis Susceptibility in Mice be Independent of the V1 Immunoglobulin Heavy Chain Gene?
### Response:
| Our data indicate that IgM-dependent protection against atherosclerosis is unlikely to be dependent on antibodies that use the VHS107.1.42 gene, in contrast to the acute immune response conferred by this heavy chain in the response to phosphocholine and in providing resistance against lethal S pneumoniae infection. |
### Instruction:
Does ouabain prevent pathological cardiac hypertrophy and heart failure through activation of phosphoinositide 3-kinase α in mouse?
### Response:
| Our results show that (a) safe doses of ouabain prevent or delay cardiac remodeling of pressure overloaded mouse heart; and (b) these prophylactic effects are due to ouabain binding to α2-isoform resulting in the selective activation of PI3Kα. Our findings also suggest that potential prophylactic use of digitalis for p... |
### Instruction:
Is previous gestational diabetes history associated with impaired coronary flow reserve?
### Response:
| Women with a GDM history may be at more risk regarding coronary microvascular dysfunction compared to the healthy ones. |
### Instruction:
Do porcine lung mesenchymal stromal cells possess differentiation and immunoregulatory properties?
### Response:
| Here, we demonstrate that MSCs can be isolated from porcine lung and that these cells, similar to human lung MSCs, possess in vitro proliferation, differentiation and immunomodulatory functions. Thus, these cells may serve as a model system to evaluate the contribution of lung MSCs in modulating the immune response, in... |
### Instruction:
Does vein Diameter on Unenhanced Multidetector CT predict Reperfusion of Pulmonary Arteriovenous Malformation after Embolotherapy?
### Response:
| A diameter of the draining vein of PAVM of 2.5 mm or greater on unenhanced MDCT is a strong predictor of reperfusion. |
### Instruction:
Does computational evaluation of exome sequence data using human and model organism phenotypes improve diagnostic efficiency?
### Response:
| Structured phenotyping of patients and computational analysis are effective adjuncts for diagnosing patients with genetic disorders.Genet Med 18 6, 608-617. |
### Instruction:
Does inhibition of MicroRNA-494 reduce Carotid Artery Atherosclerotic Lesion Development and Increases Plaque Stability?
### Response:
| Treatment with GSO-494 results in smaller atherosclerotic lesions with increased plaque stability. Inhibition of miR-494 may decrease the risk of surgical complications or even avert endarterectomy surgery in some cases. |
### Instruction:
Are cartilage stem/progenitor cells activated in osteoarthritis via interleukin-1β/nerve growth factor signaling?
### Response:
| Our results strongly suggest that NGF signaling is a contributing factor in articular cartilage degeneration in OA, which likely targets a specific subpopulation of progenitor cells, the CSPCs, affecting their migratory and matrix remodeling activities. These findings provide novel cellular/signaling therapeutic target... |
### Instruction:
Does local administration of Mitomycin-C-Treated peripheral blood mononuclear cells ( PBMCs ) prolong allograft survival in vascularized composite allotransplantation?
### Response:
| The findings of this study show that local administration of MMC-PBMCs has no side effects and significantly extends allograft survival. Further experiments with MMC-PBMCs treatments repeated at different time-points and being added to low dose immunosuppressive protocols need to be performed to improve experimental an... |
### Instruction:
Does small Molecule T315 promote Casitas B-Lineage Lymphoma-Dependent Degradation of Epidermal Growth Factor Receptor via Y1045 Autophosphorylation?
### Response:
| Our evidence suggests that T315 is a novel class of anticancer drug that is able to inhibit the growth of EGFR-TKI-resistant lung adenocarcinoma cells by inducing the degradation of EGFR. |
### Instruction:
Do study of plasma-derived miRNAs mimic differences in Huntington 's disease brain?
### Response:
| These findings suggest that microRNA changes observed in Huntington's disease brain may be detectable in plasma and have potential clinical utility. |
### Instruction:
Is [ `` Time brain '' in relapsing remitting multiple sclerosis . Current treatment concepts in immunotherapy ]?
### Response:
| For MS a "time is brain" concept would comprise an early initiation of first line therapy as well as sensitive and structured monitoring of disease activity under therapy in conjunction with a low threshold for timely treatment optimization to achieve sustained freedom from measurable disease activity. This approach ma... |
### Instruction:
Is young male mating success associated with sperm number but not with male sex pheromone titres?
### Response:
| Therefore, we suggest that in young B. anynana pheromone titres do not indicate male quality. |
### Instruction:
Does high Rate of β-Globin DNA Detection validate Self-Sampling in Herpes Simplex Virus Shedding Studies?
### Response:
| Human β-globin DNA detection rate was high, and the quantity obtained significantly increased with genital, but not oral HSV shedding. The high rate of β-globin DNA detection is consistent with high adherence to study procedures in longitudinal studies of genital herpes shedding. |
### Instruction:
Does reperfusion Beyond 6 Hours reduce Infarct Probability in Moderately Ischemic Brain Tissue?
### Response:
| Brain tissue with mild to moderate ischemia can be salvaged by reperfusion even after 6 hours. Such tissue could be targeted for intervention beyond current treatment windows. |
### Instruction:
Are low levels of physical activity associated with dysregulation of energy intake and fat mass gain over 1 year?
### Response:
| These results suggest that low levels of physical activity are a risk factor for fat mass gain. In the current sample, a threshold for achieving energy balance occurred at an activity level corresponding to 7116 steps/d, an amount achievable by most adults. This trial was registered at clinicaltrials.gov as NCT01746186... |
### Instruction:
Is intake of carbohydrates during pregnancy in obese women associated with fat mass in the newborn offspring?
### Response:
| In obese women, even those without gestational diabetes but with impaired glucose tolerance, a lower carbohydrate intake at moderate levels in late gestation is associated with a lower fat mass in their offspring at birth. The TOP study was registered at clinicaltrials.gov as NCT01345149. |
### Instruction:
Is the enhanced expression of death receptor 5 ( DR5 ) mediated by HBV X protein through NF-kappaB pathway associated with cell apoptosis induced by ( TNF-α related apoptosis inducing ligand ) TRAIL in hepatoma cells?
### Response:
| These results demonstrate that increased apoptosis induced by TRAIL is associated with increased expression of DR5 that mediated by HBX through NF-κB pathway. This finding provides a critical insight into the mechanism of hepatocyte apoptosis mediated by HBX in HBV infection. |
### Instruction:
Does tripterysium glycosides preconditioning attenuate renal ischemia/reperfusion injury in a rat model?
### Response:
| Pretreatment with tripterysium glycosides exhibited protective effect on kidney ischemia/reperfusion injury, which might be related to the alleviation of inflammation, fibrosis and the reduction in apoptosis. |
### Instruction:
Does cycling Time Trial be More Altered in Hypobaric than Normobaric Hypoxia?
### Response:
| As previously suggested, HH seems to be a more stressful stimulus, and NH and HH should not be used interchangeability when endurance performance is the main objective. The principal factor in this performance difference between hypoxic conditions seemed to be the lower peripheral oxygen saturation in HH at rest, as we... |
### Instruction:
Is loss of TBK1 a frequent cause of frontotemporal dementia in a Belgian cohort?
### Response:
| TBK1 LOF mutations are the third most frequent cause of clinical FTD in the Belgian clinically based patient cohort, after C9orf72 and GRN, and the second most common cause of clinical ALS after C9orf72. These findings reinforce that FTD and ALS belong to the same disease continuum. |
### Instruction:
Does serum Ferritin relate to Carotid Intima-Media Thickness in Offspring of Fathers With Higher Serum Ferritin Levels?
### Response:
| These results suggest a paternal-specific effect on cIMT partially reflected by father's ferritin levels. |
### Instruction:
Does prolonged Electromechanical Interval unmask Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy in the Subclinical Stage?
### Response:
| In ARVD/C-patients, EMI prolongation was present throughout the RV. In asymptomatic mutation carriers, prolonged EMI in the subtricuspid area is often detected without any additional abnormalities. These preliminary results indicate that prolonged EMI is a new parameter unmasking activation delay in the subclinical sta... |
### Instruction:
Do central memory CD4+ T cells are preferential targets of double infection by HIV-1?
### Response:
| These findings reveal that double infection in primary CD4+ T cells is primarily a consequences of cellular heterogeneity and not rescue of suboptimal provirus expression by Tat in trans. Additionally, we report a previously unappreciated phenomenon of enhanced double infection within primary TCM cells and suggest that... |
### Instruction:
Does sUMOylation of sPRDM16 promote the progression of acute myeloid leukemia?
### Response:
| Our results suggest that K568 SUMOylation of sPRDM16 plays an important role in the progression of acute myeloid leukemia. |
### Instruction:
Is prenatal exposure to bisphenol-A associated with Toll-like receptor-induced cytokine suppression in neonates?
### Response:
| This is the first cohort study that indicated prenatal BPA exposure to play a part in TLR-related innate immune response of neonatal infants. However, despite an altered immune homeostasis, result did not show such exposure to be associated with increased risk of infection during early infancy. |
### Instruction:
Is brachial Low-Flow-Mediated Constriction Associated with Delayed Brachial Flow-Mediated Dilation?
### Response:
| The present study reveals that almost 40% of the subjects had brachial artery L-FMC and a more pronounced constriction during ischemia correlated with a lower dilation after ischemia. Finally, the prevalence of subjects showing L-FMC was significantly higher among subjects with delayed or no vasodilation, suggesting th... |
### Instruction:
Is fibronectin fragment-induced expression of matrix metalloproteinases mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes?
### Response:
| Our data demonstrate that the MyD88-dependent TLR-2 signaling pathway may be responsible for 29-kDa FN-f-mediated cartilage catabolic responses. Our results will enhance understanding of cartilage catabolic mechanisms driven by cartilage degradation products, including FN-f. The modulation of TLR-2 signaling activated ... |
### Instruction:
Is ten-year survival after epithelial ovarian cancer associated with BRCA mutation status?
### Response:
| The initial survival advantage among women with BRCA mutations may reflect a higher initial sensitivity of BRCA carriers to chemotherapy, but this response does not predict long-term survival. The strongest predictor of long-term survival is status of no residual disease at resection. |
### Instruction:
Does a Food Transfer Program without a Formal Education Component modify Complementary Feeding Practices in Poor Rural Mexican Communities?
### Response:
| These findings suggest that in order to improve dietary quality in children, food baskets that include fortified complementary foods may be more effective than cash transfers. The fact that the 2 food basket groups differed in the observed impact does not allow for more convincing conclusions to be made about the educa... |
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