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### Instruction:
Does murine Aβ over-production produce diffuse and compact Alzheimer-type amyloid deposits?
### Response:
| These findings demonstrate that murine Aβ peptides have the capacity to produce amyloid deposits that are morphologically similar to deposits found in human AD provided the murine APP gene harbors mutations linked to human FAD. |
### Instruction:
Do tridax procumbens flavonoids promote osteoblast differentiation and bone formation?
### Response:
| Our findings point towards the induction of osteoblast differentiation by TPFs and suggested that TPFs could be a potential anabolic agent to treat patients with bone loss-associated diseases such as osteoporosis. |
### Instruction:
Do elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass?
### Response:
| HP eradication might reduce LMM risk. This finding should be confirmed in prospective longitudinal studies to determine the long-term effects of HP eradication on sarcopenia. |
### Instruction:
Does demoralisation syndrome explain the psychological profile of community-based asylum-seekers?
### Response:
| Demoralisation was widespread through the asylum-seeker and refugee population and its prevalence was attributable to a range of social and psychiatric factors. However, DS had little explanatory power for psychiatric morbidity, which was more suggestive of a pan-distress symptom complex. |
### Instruction:
Do patient age and breast resection weight affect immediate postmastectomy breast reconstruction in ductal carcinoma in situ?
### Response:
| In our series, older patients or patients with larger breasts (irrespective of the body mass index) were less likely to undergo IBR. In order to be in line with the patient's desire, the surgeons of our unit should broaden their indications of IBR. The lack of reconstruction of large breasts should certainly be compens... |
### Instruction:
Does leukotriene B4 inhibit L-Type Calcium Channels via p38 Signaling Pathway in Vascular Smooth Muscle Cells?
### Response:
| We conclude that LTB4 inhibits L-type calcium channels through BLT1-TAk1-p38 signaling pathway. The LTB4 inhibitory effect on L-type calcium channels may be involved in its pathological processes such as atherosclerosis. |
### Instruction:
Is platelet volume associated with the Framingham risk score for cardiovascular disease in the Brazilian Longitudinal Study of Adult Health ( ELSA-Brasil )?
### Response:
| Increased PVI was independently correlated with higher CVD risk based on the FRS, diabetes, and systolic hypertension. Prospective follow up of this cohort is warranted to confirm that PVI is associated with the development of CVD. |
### Instruction:
Do airborne allergens induce protease activated receptor-2-mediated production of inflammatory cytokines in human gingival epithelium?
### Response:
| GCE activates PAR-2, which can induce PLC/IP3-dependent Ca(2+) signaling pathway, ultimately triggering inflammation via the production of pro-inflammatory cytokines such as IL-1β, IL-6, IL-8, and NLRP 3 in HGECs. |
### Instruction:
Is therapeutic temperature modulation associated with pulmonary complications in patients with severe traumatic brain injury?
### Response:
| Exposure to TTM is associated with an increase in pulmonary complications. These findings support more attention to these complications in studies of TTM in TBI patients. |
### Instruction:
Do spatial epidemiology and serologic cohorts increase the early detection of leprosy?
### Response:
| Targeted screening involving school-based surveillance planned using results obtained by spatial analysis and targeted household and individual continuous surveillance based on serologic data should be applied to increase the early detection of new leprosy cases. |
### Instruction:
Does c-Reactive Protein Level be an Indicator of the Aggressiveness of Advanced Pancreatic Cancer?
### Response:
| C-reactive protein stratified the outcomes, systemic weakness, and tumor burden. C-reactive protein is an indicator of the aggressiveness of advanced PCa. |
### Instruction:
Does miR-634 restore drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway?
### Response:
| miR-634 levels determine chemosensitivity in ovarian cancer cells. We identify miR-634 as a therapeutic candidate to resensitize chemotherapy resistant ovarian tumors. |
### Instruction:
Does implantable Colonic Electrical Stimulation improve Gastrointestinal Transit and Defecation in a Canine Constipation Model?
### Response:
| This double-site implantable CES can improve the gastrointestinal transit and defecation in a canine STC model, possibly by activating the cholinergic and nitrergic pathways. The CES mode used in this study may be proven feasible in treating STC. |
### Instruction:
Does a novel gastrointestinal microbiome modulator from soy pods reduce absorption of dietary fat in mice?
### Response:
| A novel dietary intervention derived from soy pods that acts to hinder absorption of dietary fat and glucose in mice was developed. More studies with this GIMM in animal models of diet-induced nonalcoholic fatty liver diseases, type 2 diabetes, and autism are needed. |
### Instruction:
Is sOX4 expression associated with treatment failure and chemoradioresistance in oral squamous cell carcinoma?
### Response:
| SOX4 may contribute to oncogenic phenotypes of HNSCC cells by promoting cell survival and causing chemoradioresistance. It could be a potential prognostic marker for OSCC. |
### Instruction:
Is radiographic progression associated with increased cardiovascular risk in patients with axial spondyloarthritis?
### Response:
| The FRS was higher in axSpA patients than in a matched general population. Radiographic progression in the spine was associated with a high estimated 10-year CVD risk. |
### Instruction:
Does simvastatin inhibit oxidative stress via the activation of nuclear factor erythroid 2-related factor 2 signaling in trophoblast cells?
### Response:
| Hypoxia is one of the important negative regulators of Nrf2 activation, and simvastatin inhibits oxidative stress through the activation of Nrf2 signaling in trophoblasts, indicating the potential therapeutic role of statin for pre-eclampsia. |
### Instruction:
Does miRNA-548p suppress hepatitis B virus X protein associated hepatocellular carcinoma by downregulating oncoprotein hepatitis B x-interacting protein?
### Response:
| We proposed the model for HBx/HNF4A/miR-548p/HBXIP pathway that controls hepatoma cell growth and tumorigenesis of HCC. miR-548p was identified as a tumor-suppressor in HBx-associated hepatocellular carcinogenesis. |
### Instruction:
Are high levels of physical activity associated with poorer asthma control in young females but not in males?
### Response:
| Young asthma patients were more active than controls. High levels of physical activity were associated with poor asthma control as judged by the ACT in females, but not in males, and this appears unrelated to airway inflammation or responsiveness. |
### Instruction:
Does enterococcus faecalis attenuate osteogenesis through activation of p38 and ERK1/2 pathways in MC3T3-E1 cells?
### Response:
| E. faecalis exerted an inhibitory effect on osteogenesis in pre-osteoblastic MC3T3-E1 cells via phosphorylation of p38 and ERK1/2. |
### Instruction:
Does combination of ultrasound and newly synthesized magnetic nanocapsules affect the temperature profile of CT26 tumors in BALB/c mice?
### Response:
| Data presented in this study would be helpful to develop an ultrasound-mediated MDT procedure so that temperature changes of the tumor and its surrounding normal tissues may be controllable. |
### Instruction:
Is aXL a potential therapeutic target in dedifferentiated and pleomorphic liposarcomas?
### Response:
| Our results suggest that AXL signaling contributes to the aggressiveness of DDLPS and PLS, and that AXL is therefore a potential therapeutic target for treatment of these rare, yet devastating tumors. |
### Instruction:
Is epstein-Barr virus positivity , not mismatch repair-deficiency , a favorable risk factor for lymph node metastasis in submucosa-invasive early gastric cancer?
### Response:
| EBV positivity was a favorable risk factor for LNM in SM EGC. However, MMR deficiency was not associated with the status of LNM. Thus, we suggest that examination with EBER ISH could be considered for endoscopic resected specimens, especially in cases of SM EGC showing no LVI and clear resection margins. |
### Instruction:
Does asthma medication ratio predict emergency department visits and hospitalizations in children with asthma?
### Response:
| The asthma medication ratio is a significant predictor of ED visits and hospitalizations in children. Using a cutoff of <0.5 to signal at-risk patients may be an effective way for populations who would benefit from increased use of controller medications to reduce future emergent asthma visits. CPT only copyright XXXX-... |
### Instruction:
Is obesity associated with type 2 diabetes mellitus linked to decreased PC1/3 mRNA expression in the Jejunum?
### Response:
| The results suggest that bioactivation of pro-GIP and proglucagon could be impaired by the lower expression of PC1/3 mRNA in jejunum cells of obese patients with T2DM. However, after surgery, food could activate this system and improve glucose levels in these patients. |
### Instruction:
Are metabolic syndrome , alcohol consumption and genetic factors associated with serum uric acid concentration?
### Response:
| Metabolic syndrome, moderate wine drinking and the c.421C>A variant in the ABCG gene are independently associated with the serum uric acid concentration. Our model indicates that uric acid should be clinically monitored in persons with metabolic syndrome. |
### Instruction:
Is physical functioning associated with processing speed and executive functions in community-dwelling older adults?
### Response:
| These results suggest that cognition is related to simple performance-based physical tests and highlight the importance of intervention studies aimed at enhancing cognitive and physical functioning in older adults. |
### Instruction:
Is skeletal muscle depletion an independent prognostic factor for hepatocellular carcinoma?
### Response:
| Skeletal muscle depletion is an independent prognostic factor. Intervention to prevent muscle wasting might be an effective strategy for improving the outcome of HCC. |
### Instruction:
Does c-Met pathway promote self-renewal and tumorigenecity of head and neck squamous cell carcinoma stem-like cell?
### Response:
| Our results suggest that inhibition of the c-Met pathway could serve as a potent therapeutic strategy to target HNSCC stem-like cells. |
### Instruction:
Does autophagy inhibitor 3-methyladenine potentiate apoptosis induced by dietary tocotrienols in breast cancer cells?
### Response:
| Together, our data indicate anticancer effects of Tocomin® in breast cancer cells, which is potentiated by the autophagy inhibitor 3-MA. |
### Instruction:
Do calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects?
### Response:
| Calorie restriction and RYGB have opposite effects on serum bile salt and FGF21 levels. Calorie restriction results in FGF21 approaching nonobese control levels, suggesting that this intervention is effective in reducing the "nutritional crisis" that appears to underly FGF21 elevation in obesity. FGF21 elevation after ... |
### Instruction:
Does oleanolic acid induce apoptosis of MKN28 cells via AKT and JNK signaling pathways?
### Response:
| OA induces apoptosis of MKN28 cells via the mitochondrial pathway regulated by AKT and JNK signaling pathways. |
### Instruction:
Is risk of nephrogenic systemic fibrosis low in patients with chronic liver disease exposed to gadolinium-based contrast agents?
### Response:
| Chronic liver disease does not appear to be a significant risk factor for NSF. |
### Instruction:
Does tobacco smoking increase the risk for death from pneumococcal pneumonia?
### Response:
| Current smokers with pneumococcal CAP often develop severe sepsis and require hospitalization at a younger age, despite fewer comorbid conditions. Smoking increases the risk of 30-day mortality independently of tobacco-related comorbidity, age, and comorbid conditions. Current smokers should be actively targeted for pr... |
### Instruction:
Does cardiac-specific YAP activation improve cardiac function and survival in an experimental murine MI model?
### Response:
| Cardiac-specific YAP activation after MI mitigated myocardial injury, improved cardiac function, and enhanced survival. These findings suggest that therapeutic activation of YAP or its downstream targets, potentially through AAV-mediated gene therapy, may be a strategy to improve outcome after MI. |
### Instruction:
Does lPS preconditioning ameliorate intestinal injury in a rat model of hemorrhagic shock?
### Response:
| Endotoxin preconditioning can lessen the effects of ischemia and reperfusion injury in intestinal mucosa of a rat model with hemorrhagic shock. It is hypothesized that this effect is mediated via inhibition of TLR4 over-expression. |
### Instruction:
Do phylogenetic analyses provide the first insights into the evolution of OVATE family proteins in land plants?
### Response:
| This first genome-wide survey on OFPs provides new insights into the evolution of the OVATE protein family and establishes a solid base for future functional genomics studies on this important but poorly characterized regulatory protein family in plants. |
### Instruction:
Does benzodiazepine & nonbenzodiazepine prescriptions for Taiwanese elderly with type 2 diabetes contribute to cognitive dysfunction?
### Response:
| In our research, cognitive dysfunction was associated with diabetes. BZD/nonBZD may have conferred additional risk of cognitive impairment in our elderly diabetic patients. We should consider examining the mental function of DM patients regularly and try our best to avoid potentially inappropriate medications (PIMs). |
### Instruction:
Do fish oil and krill oil supplementations differentially regulate lipid catabolic and synthetic pathways in mice?
### Response:
| The data show that both FO and KO promote lowering of plasma lipids and regulate lipid homeostasis, but with different efficiency and partially via different mechanisms. |
### Instruction:
Is baseline metabolic tumour volume an independent prognostic factor in Hodgkin lymphoma?
### Response:
| TMTV0 is more relevant than tumour bulk for predicting the outcome in patients with HL, and adds a significant prognostic insight to interim PET response assessment. The combination of TMTV0 and ΔSUVmaxPET0-2 made it possible to identify three subsets of HL patients with different outcomes. This may guide clinicians in... |
### Instruction:
Are bothrops jararaca venom metalloproteinases essential for coagulopathy and increase plasma tissue factor levels during envenomation?
### Response:
| SVMP induce coagulopathy, hemorrhage and increased TF levels in plasma, but neither SVMP nor SVSP are directly involved in thrombocytopenia. High levels of TF in plasma and TF decryption occur during snake envenomation, like true disseminated intravascular coagulation syndrome, and might be implicated in engendering bl... |
### Instruction:
Does executive function in preschool children with cerebral palsy -- Assessment and early intervention -- A pilot study?
### Response:
| The children in our sample showed age-appropriate levels of executive functions before attending PIH. Some aspects of executive skills difficulties were reduced after PIH. Using BRIEF-P contributed to the differentiation of cognitive strengths and weaknesses among the children. |
### Instruction:
Does endoderm-specific deletion of Tbx1 reveal an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis?
### Response:
| Tbx1 deletion from the pharyngeal endoderm is sufficient to cause caudal pharyngeal arch segmentation defects by FGF-independent effectors that remain to be identified. |
### Instruction:
Are african-American patients less likely to receive drug-eluting stents during percutaneous coronary intervention?
### Response:
| African-American race continues to have a significant impact upon the decision to use DES. Future research should focus upon patient and provider perceptions at the time of PCI. |
### Instruction:
Are bacterial biofilms on implanted suture material a cause of surgical site infection?
### Response:
| Bacterial biofilms on implanted suture material can manifest as persistent surgical site infections that require complete removal of the underlying foreign body substrata for resolution. |
### Instruction:
Does nrf2 induce cisplatin resistance through activation of autophagy in ovarian carcinoma?
### Response:
| Nrf2-activated autophagy may function as a novel mechanism causing cisplatin-resistance. |
### Instruction:
Do intraepithelial lymphocyte eotaxin-2 expression and perineural mast cell degranulation differentiate allergic/eosinophilic colitis from classic IBD?
### Response:
| Eotaxin-2+ IELs may contribute to the periepithelial eosinophil accumulation characteristic of allergic colitis. The colocalisation of IgE and tryptase with mucosal enteric nerves is likely to promote the dysmotility and visceral hyperalgesia classically seen in allergic gastrointestinal inflammation. |
### Instruction:
Is expression of short chain fatty acid receptors and pro-inflammatory cytokines in utero-placental tissues altered in cows developing retention of fetal membranes?
### Response:
| Since a clear association of butyrate levels, expression of pro-inflammatory cytokines, adhesion molecules and SCFAs receptors was observed with expulsion of fetal membranes, modulating the levels of these molecules prior to parturition might help in reducing the incidence of RFM in cows. |
### Instruction:
Does cDX1 restrict the invasion of HTR-8/SVneo trophoblast cells by inhibiting MMP-9 expression?
### Response:
| Altogether, we found that in trophoblast cells, CDX1 reduced invasion independently of the PI3K/AKT signaling pathway. Furthermore, CDX1 functions in concert with PI3K/AKT signaling to regulate trophoblast invasion. We concluded that CDX1 restricts the invasion of HTR-8/SVneo trophoblast cells by inhibiting MMP-9 expre... |
### Instruction:
Does vinpocetine attenuate neointimal hyperplasia in diabetic rat carotid arteries after balloon injury?
### Response:
| Vinpocetine attenuated neointimal formation in diabetic rats and inhibited HG-induced VSMCs proliferation, chemokinesis and apoptotic resistance by preventing ROS activation and affecting MAPK, PI3K/Akt, and NF-κB signaling. |
### Instruction:
Is readmission after lung cancer resection associated with a 6-fold increase in 90-day postoperative mortality?
### Response:
| Factors associated with early readmission after lung cancer resection include patient comorbidities, type of operation, and socioeconomic factors. Metrics that only report readmissions to the operative provider miss one-fourth of all cases. Readmitted patients have an increased risk of death and demand maximum attentio... |
### Instruction:
Is efficacy of metformin-based oral antidiabetic drugs inferior to insulin glargine in newly diagnosed type 2 diabetic patients with severe hyperglycemia after short-term intensive insulin therapy?
### Response:
| The effects of metformin-based OAD therapy on glycemic control and improvements in β-cell function are not inferior to glargine in newly diagnosed T2D patients with severe hyperglycemia after short-term ITT. Considering the superiority of metformin in terms of safety, cost, and convenience, metformin-based OAD therapy ... |
### Instruction:
Does pyruvate kinase M2 regulate apoptosis of intestinal epithelial cells in Crohn 's disease?
### Response:
| The up-regulation of PKM2 might protect IECs against apoptosis possibly through Bcl-xl in CD, indicating its important role in the pathophysiology of CD. |
### Instruction:
Does cholecystokinin mediate progression and metastasis of pancreatic cancer associated with dietary fat?
### Response:
| CCK is a mediator of dietary fat-associated pancreatic cancer. CCK is also involved in the invasiveness of pancreatic tumors through a mechanism involving VEGF-A. |
### Instruction:
Are pD-L1 gene polymorphisms and low serum level of PD-L1 protein associated to type 1 diabetes in Chile?
### Response:
| Two polymorphism of PD-L1 are presented in different allelic variants between T1D and healthy subjects, also PDL-1 serum levels are significantly lowered in diabetics patients. Moreover, the age of onset of the disease determine differences between serum ligand levels in diabetics, being lower in younger. These results... |
### Instruction:
Does advanced age impair cardioprotective function of mesenchymal stem cell transplantation from patients to myocardially infarcted rats?
### Response:
| Transplantation of hMSCs improves heart function, but proliferative ability and myocardial protection decrease with older MSCs, likely due to differences between VEGF and Bcl-2 expression and reduced anti-apoptosis. |
### Instruction:
Does circumstances leading to injurious fall in older men and women in the Netherlands?
### Response:
| In the present study we found that the indoor activities distribution leading to TBIs and hip fractures differed. Notably, about half of the traumatic brain injuries and hip fractures in men and women aged 65-79 years occurred outdoors. This study provides new insights into patterns leading to injurious falls by age, g... |
### Instruction:
Is carotid intima-media thickness associated with incident heart failure among middle-aged whites and blacks : the Atherosclerosis Risk in Communities study?
### Response:
| Increasing carotid IMT is associated with incident HF in middle-aged whites and blacks, beyond risks explained by major CVD risk factors and CHD. This suggests that carotid IMT may be associated with HF through mechanisms different from myocardial ischemia or infarction. |
### Instruction:
Is sTAG2 loss of expression rare in aneuploid malignant salivary gland neoplasms?
### Response:
| Aneuploidy in human salivary gland carcinomas is not driven by loss of expression of STAG2. |
### Instruction:
Is exposure to Leadership WalkRounds in neonatal intensive care units associated with a better patient safety culture and less caregiver burnout?
### Response:
| WR are linked to patient safety and burnout. In NICUs, where they occurred more often, the workplace appears to be a better place to deliver and to receive care. |
### Instruction:
Is high level antibody avidity achieved in HIV-seropositive recipients of an inactivated split adjuvanted ( AS03A ) influenza vaccine?
### Response:
| In participants initially seronegative, two doses of vaccine enabled a greater percentage of subjects to respond to the vaccine and elicited higher HAI titers. All subjects who produced detectable HAI titers also rapidly generated high AI in the short and long term. We demonstrate that high avidity antibodies can be ac... |
### Instruction:
Are premenstrual symptoms in fertile age associated with impaired quality of life , but not hot flashes , in recently postmenopausal women?
### Response:
| The occurrence of premenstrual symptoms in fertile age is associated with impaired quality of life, but not hot flashes, in recently postmenopausal women. |
### Instruction:
Does centralized molecular testing for oncogenic gene mutations complement the local cytopathologic diagnosis of thyroid nodules?
### Response:
| Centralized and standardized molecular testing for genetic alterations associated with a high risk of malignancy efficiently complements the local cytopathologic diagnosis of thyroid nodule aspirates in the clinical setting. Actionable molecular cytology can improve the personalized surgical and medical management of p... |
### Instruction:
Is activation of noncanonical Wnt signaling through WNT5A in visceral adipose tissue of obese subjects related to inflammation?
### Response:
| Activation of noncanonical Wnt signaling through the up-regulation of WNT5A and down-regulation of SFRP5 may promote a proinflammatory state in visceral adipose tissue contributing to the development of obesity-associated comorbidities. |
### Instruction:
Does dynamic behavior of lymphocyte subgroups correlate with clinical outcomes in human H7N9 infection?
### Response:
| H7N9-infected individuals have low proportions of peripheral blood T lymphocyte subgroups, particularly those suffering fatal infections. The numbers of CD3(+) T cells (including CD4(+) and CD8(+) T cells) may predict the clinical outcome of human H7N9 infection. |
### Instruction:
Do economic impact of 13-valent pneumococcal conjugate vaccine in Finnish adults ≥50 years with underlying chronic medical conditions?
### Response:
| In Finland, the immunization with PCV13 vaccine, of adults (≥50 years) at moderate and high risk of IPD, is estimated to lead to substantial cost savings in the 5 years after vaccination. |
### Instruction:
Is expression of multiple Sox genes through embryonic development in the ctenophore Mnemiopsis leidyi spatially restricted to zones of cell proliferation?
### Response:
| Our results are consistent with the established role of multiple Sox genes in the maintenance of stem cell pools. Both similarities and differences in juvenile cydippid stage expression patterns between Mnemiopsis Sox genes and their orthologs from Pleurobrachia highlight the importance of using multiple species to cha... |
### Instruction:
Are laparoscopic skills and cognitive function affected in surgeons during a night shift?
### Response:
| Sleep deprivation during a 17-hour night shift did not impair surgeons' psychomotor or cognitive performance. |
### Instruction:
Is coexpression of CD44-positive/CD133-positive cancer stem cells and CD204-positive tumor-associated macrophages a predictor of survival in pancreatic ductal adenocarcinoma?
### Response:
| Coexpression of CD44/CD133 and CD204 is a useful survival prediction marker for patients with PDAC. |
### Instruction:
Does the dual PI3K/mTOR inhibitor PKI-587 enhance sensitivity to cetuximab in EGFR-resistant human head and neck cancer models?
### Response:
| Phosphoinositide 3-kinase/mammalian target of rapamycin inhibition has an important role in the rescue of cetuximab resistance. Different mechanisms of cell death are induced by combined treatment depending on basal anti-EGFR responsiveness. |
### Instruction:
Does microRNA-126 inhibit invasion in bladder cancer via regulation of ADAM9?
### Response:
| In this study we describe the role of miR-126 in bladder cancer progression, identifying miR-126 and ADAM9 as potential clinical biomarkers of disease aggressiveness. |
### Instruction:
Does recommendations for intensive care follow-up clinics ; report from a survey and conference of Dutch intensive care?
### Response:
| This study recommends how to organize post-ICU clinics based on literature and expert opinion. The implementation of the recommendations will facilitate the set-up of post-ICU clinics, research on effectiveness of post-ICU clinics and benchmarking of quality of ICU care. |
### Instruction:
Is statin therapy associated with a reduced risk of non-alcoholic fatty liver in overweight individuals?
### Response:
| Within the Rotterdam study, in patients with body mass index ≥ 27.5 current use of statins for >2 years was associated with a lower prevalence of steatosis. |
### Instruction:
Does subcutaneous placement of lap band port without fascial fixation provide safe and durable access?
### Response:
| Superficial subcutaneous placement of Lap Band Port using mesh fixation without anchoring the port to the fascia provides safe and durable access. Deep incisions to secure the port directly to the fascia might not be necessary. |
### Instruction:
Does neuropeptide trefoil factor 3 attenuate naloxone-precipitated withdrawal in morphine-dependent mice?
### Response:
| These findings indicate that TFF3 might be a potential therapeutic candidate for opiate addiction by regulating glucocorticoid secretion and neuronal activation in the prefrontal cortex. |
### Instruction:
Is pre-pregnancy restless legs syndrome ( Willis-Ekbom Disease ) associated with perinatal depression?
### Response:
| Women with RLS onset before pregnancy with moderate or severe symptoms had an increased risk of both antenatal and postnatal depression. The self-reported prevalence of RLS during pregnancy is lower when a questionnaire dealing with "mimics" is used. |
### Instruction:
Is total number of lymph node metastases a more significant risk factor for poor prognosis than positive lateral lymph node metastasis?
### Response:
| The presence of one or two LLN metastases in patients who have undergone LLN dissection with surgery for lower rectal cancer is not associated with poor prognosis. The number of LLN metastases is a more significant risk factor for poor prognosis. |
### Instruction:
Are cYP2B6 516G > T ( rs3745274 ) and smoking status associated with efavirenz plasma concentration in a Serbian cohort of HIV patients?
### Response:
| The effects of CYP2B6 516G>T (rs3745274) and smoking status on EFV plasma concentration in the Serbian population have been established for the first time. |
### Instruction:
Is functional promoter -765 G > C variant in COX-2 gene associated with the susceptibility of breast cancer in Chinese Han women?
### Response:
| Our results suggest that the functional -765 G > C polymorphism in the promoter of COX-2 may influence the susceptibility and progression of breast cancer in the Chinese Han population. |
### Instruction:
Do telemental health evaluations enhance access and efficiency in a critical access hospital emergency department?
### Response:
| Telemedicine appears to be an effective intervention for mentally ill patients by providing more timely access to mental health evaluations in rural hospital emergency departments. |
### Instruction:
Does late reactivation of herpes zoster keratitis result in band keratopathy?
### Response:
| The chronic and recurrent nature of HZO can be associated with significant corneal morbidity, even many years after the initial zoster episode. Long-term review and management of patients with a history of herpes zoster stromal keratitis are indicated following the initial corneal involvement. Standardized antibacteria... |
### Instruction:
Do protein kinase d isoforms differentially modulate cofilin-driven directed cell migration?
### Response:
| Our data suggest that PKD complexes provide an interface for both cofilin regulatory pathways. Dependent on the activity of involved PKD enzymes signaling can be balanced to guarantee a functional cofilin activity cycle and increase cell migration, or imbalanced to decrease cell migration. Our data also provide an expl... |
### Instruction:
Is seasonality pattern of breast , colorectal , and prostate cancer dependent on latitude?
### Response:
| These observations contribute to the mounting evidence that vitamin D3 may affect the progression of cancer. Data also suggest that vitamin D3 status at the onset of treatment may synergistically improve the prognosis of several cancer types. |
### Instruction:
Does α5β1 integrin signaling mediate oxidized low-density lipoprotein-induced inflammation and early atherosclerosis?
### Response:
| Our data suggest that α5β1-mediated cross-talk between fibronectin and oxLDL regulates inflammation in early atherogenesis and that therapeutics that inhibit α5 integrins may reduce inflammation without adversely affecting plaque structure. |
### Instruction:
Do lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension?
### Response:
| Lysyl oxidases are dysregulated in clinical and experimental PH. Lysyl oxidases play a causal role in experimental PH and represent a candidate therapeutic target. Our proof-of-principle study demonstrated that modulation of lung matrix cross-linking can affect pulmonary vascular remodeling associated with PH. |
### Instruction:
Does use of time from fever onset improve the diagnostic accuracy of C-reactive protein in identifying bacterial infections?
### Response:
| Clinicians should apply different CRP cut-off values depending on whether they are trying to rule in or rule out bacterial infection, but also depending on fever duration at the time of CRP testing. |
### Instruction:
Does novel photodynamic therapy prevent new skin cancers -- randomized controlled trial?
### Response:
| Novel ALA made no difference in the likelihood of new malignancies developing. The risks without benefit of this novel ALA are troubling. Lack of efficacy and safety of novel ALA cannot be extrapolated to other PDT products. |
### Instruction:
Do high drain amylase and lipase values predict post-operative pancreatitis for choledochal cyst?
### Response:
| It was indicated that amylase and lipase values in drainage at 1 POD could be effective predictors of post-operative pancreatitis after CEHE. |
### Instruction:
Does dLK1 regulate branching morphogenesis and parasympathetic innervation of salivary glands through inhibition of NOTCH signalling?
### Response:
| Our data suggest that DLK1 regulates SMGs morphogenesis and parasympathetic nerve fibre outgrowth through inhibition of NOTCH signalling. |
### Instruction:
Does morphometric subaxial lateral mass evaluation allow for preoperative optimal screw trajectory planning?
### Response:
| The optimal LM trajectory varied for each subaxial segment. The knowledge of LM geometry allows for safe, long and even bicortical screw placements using preoperative sagittal CT imaging evaluations. |
### Instruction:
Does sampling rate of heart rate variability impact the ability to detect acidemia in ovine fetuses near-term?
### Response:
| RMSSD as a measure of fHRV when calculated from FHR sampled at 1000 Hz allowed for the early detection of worsening hypoxic-acidemia in each fetus. However, when calculated at the low sampling rate of 4 Hz used clinically, RMSSD remained unchanged until terminally when the nadir pH was reached. For early detection of f... |
### Instruction:
Does [ TLR4 contribute to intestinal hyperpermeability in alcoholic liver disease ]?
### Response:
| Chronic alcohol exposure induced TLR4 expression and cellular permeability in gut tissues. Activation of TLR4 may be involved in development of gut leakiness in alcoholic liver disease. |
### Instruction:
Does continuous fever-range heat stress induce thermotolerance in odontoblast-lineage cells?
### Response:
| The appropriate pretreatment with continuous fever-range heat stress can provide protection against lethal heat shock in KN-3 cells. |
### Instruction:
Are endothelial progenitor cells and endothelial microparticles independent predictors of endothelial function?
### Response:
| Obese children demonstrate impaired endothelial microvascular function, increased arterial stiffness, fewer EPCs, and more EMPs. Besides systolic blood pressure, EPC and EMP counts independently predict the presence of microvascular endothelial dysfunction. |
### Instruction:
Are p21 rs3176352 G > C and p73 rs1801173 C > T polymorphisms associated with an increased risk of esophageal cancer in a Chinese population?
### Response:
| p21 rs3176352 G>C and p73 rs1801173 C>T SNPs are associated with increased risk of ESCC. To confirm the current findings, additional, larger studies and tissue-specific biological characterization are required. |
### Instruction:
Is aortic stiffness associated with white matter integrity in patients with type 1 diabetes?
### Response:
| Our data suggest that aortic stiffness is independently associated with reduced white matter integrity in patients with type 1 diabetes. |
### Instruction:
Does hypercholesterolemia inhibit re-endothelialization of arterial injuries by TRPC channel activation?
### Response:
| Results suggest that activation of TRPC6 and TRPC5 channels is the key contributor to impaired endothelial healing of arterial injuries in hypercholesterolemic mice. |
### Instruction:
Does ten-year review reveal changing trends and severity of allergic reactions to nuts and other foods?
### Response:
| Peanut and tree nut reactions were more likely to result in adrenaline treatment and hospitalisation than other food reactions. Peanut and cashew nut reactions were more likely to cause anaphylaxis than hazelnuts. Cashew nut reactions increased during the study period. |
### Instruction:
Is phase-rectified signal averaging for intrapartum electronic fetal heart rate monitoring related to acidaemia at birth?
### Response:
| DC(PRSA) of the FHR can be measured in labour, and appears to predict acidaemia more accurately than STV. Further prospective evaluation is warranted to assess whether this could be clinically useful. The weak correlation between DC(PRSA) and STV suggests that they could be combined in multivariate FHR analyses. |
### Instruction:
Does malleable endoscope increase surgical freedom compared with a rigid endoscope in endoscopic endonasal approaches to the parasellar region?
### Response:
| This study demonstrates that application of a malleable endoscope to transsphenoidal approaches to the parasellar region decreases instrument-endoscope conflict and improves surgical freedom. |
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