question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Is heat stress associated with reduced health status in pulmonary arterial hypertension : a prospective study cohort?
### Response:
| Heat stress is associated with a compromised clinical status in patients with PAH. Adaptation strategies must be implemented to prevent heart-related morbidity, including therapeutic adjustments and adequate room cooling in the patient's home and at the hospital. |
### Instruction:
Is malperfusion syndrome without organ failure a risk factor for surgical procedures for type A aortic dissection?
### Response:
| Mortality was not increased in asymptomatic patients with malperfusion by laboratory or imaging findings. Immediate operation before progression of organ malperfusion is still a valid option for patients with acute type A dissection. |
### Instruction:
Does self-reported health-related quality of life predict 5-year mortality and hospital readmissions in patients with ischaemic heart disease?
### Response:
| This study shows a significant and linear relationship between lower global and physical HRQL scores in patients with IHD and 5-year all-cause mortality and cardiac readmission. |
### Instruction:
Is migraine frequent in children and adolescents with neurofibromatosis type 1?
### Response:
| Children and adolescents with NF1 are prone to migraines. Complaints of headache are very frequent in this population. |
### Instruction:
Does sPRY4-mediated ERK1/2 signaling inhibition abolish 17β-estradiol-induced cell growth in endometrial adenocarcinoma cell?
### Response:
| SPRY4 may function as a tumor suppressor in endometrial adenocarcinoma. |
### Instruction:
Does gnetin H isolated from Paeonia anomala inhibit FcεRI-mediated mast cell signaling and degranulation?
### Response:
| These results suggest that PAE and its active compound gnetin H could be promising therapeutic agents for allergic disorders. |
### Instruction:
Does rule breaking mediate the developmental association between GABRA2 and adolescent substance abuse?
### Response:
| GABRA2 represents an early risk factor for an externalizing pathway to the development of problematic alcohol and drug use. |
### Instruction:
Is bRCA1 promoter methylation a marker of better response to platinum-taxane-based therapy in sporadic epithelial ovarian cancer?
### Response:
| BRCA1 promoter methylation is predictive for better response to platinum-taxane-based therapy in EOC. |
### Instruction:
Are interleukin-1 receptor gene variants associated with aggressive periodontitis in the Japanese?
### Response:
| A genetic susceptibility locus for AgP may lie within or close to the IL1R2 locus. Further studies in other populations are necessary to confirm these results. |
### Instruction:
Is methionine synthase reductase A66G polymorphism associated with breast cancer susceptibility - a meta-analysis?
### Response:
| Our findings suggested that MTRR A66G polymorphism was not associated with breast cancer susceptibility. |
### Instruction:
Do [ The treatment of glottic carcinoma with high-frequency electrotome ]?
### Response:
| It is unnecessary to invest in expensive equipment in the cordectomy under micro-laryngoscopy with high frequency electrotome under general anesthesia and the result is satisfactory. |
### Instruction:
Does targeting eIF4GI translation initiation factor afford an attractive therapeutic strategy in multiple myeloma?
### Response:
| Our findings substantiate that translation initiation of particular targets in MM is contingent on the function of eIF4GI, critical to cell phenotype, and mark it as a viable target for pharmacological intervention. |
### Instruction:
Do differences in muscle strength after ACL reconstruction influence cardiorespiratory responses to isometabolic exercise?
### Response:
| Our findings indicate that, four months after ACL surgery, there is a significant deficit in isokinetic strength in the involved limb, but these differences in muscle strength requirement do not produce differences in the cardiorespiratory adjustments to exercise. Based on the hypotheses from the literature which expla... |
### Instruction:
Does [ Toll-like receptor 4 promote macrophage foam cell formation induced by oxidized low-density/β₂-glycoprotein I/β₂-glycoprotein I antibodies complex ]?
### Response:
| TLR4 can enhance ox-LDL/β₂GPI/anti-β₂GPI complex induced peritoneal macrophage foam cell formation via upregulating phosphorylation-NF-κB, TF and MCP-1 expression. |
### Instruction:
Do [ Platelet derived growth factor receptor β over-expression in endothelial progenitor cells promote reendothelialization after vascular injury ]?
### Response:
| Transplantation of PDGFR-β over-expressed EPCs can promote reendothelialization in the early phase after carotid artery injury. |
### Instruction:
Does asymptomatic HIV-associated neurocognitive impairment increase risk for symptomatic decline?
### Response:
| This longitudinal study demonstrates that ANI conveys a 2-fold to 6-fold increase in risk for earlier development of symptomatic HAND, supporting the prognostic value of the ANI diagnosis in clinical settings. Identifying those at highest risk for symptomatic decline may offer an opportunity to modify treatment to dela... |
### Instruction:
Does mutant ELOVL4 that cause autosomal dominant stargardt-3 macular dystrophy is misrouted to rod outer segment disks?
### Response:
| We propose that expression and outer segment mislocalization of the disease-linked 5-base-pair deletion mutant ELOVL4 protein alters photoreceptor structure and function, which subsequently results in retinal degeneration, and suggest three possible mechanisms by which mutant ELOVL4 may induce retinal degeneration in S... |
### Instruction:
Do plasma ADMA concentrations associate with aerobic fitness in postmenopausal women?
### Response:
| We found that plasma ADMA concentrations were associated with aerobic fitness in postmenopausal women. The results of this study suggest that habitual aerobic exercise may decrease plasma ADMA concentrations. |
### Instruction:
Does a formyl peptide receptor agonist suppress inflammation and bone damage in arthritis?
### Response:
| The FPR agonist Cpd43 reduced osteoclastogenesis and inflammation in a mouse model of RA and exhibited anti-inflammatory effects in relevant human cells. These data suggest that FPR ligands may represent novel therapeutic agents capable of ameliorating inflammation and bone damage in RA. |
### Instruction:
Is intrauterine exposure to cigarette smoke associated with increased ghrelin concentrations in adulthood?
### Response:
| Smoking during pregnancy may be considered as an adverse intrauterine influence that may alter the endocrine-metabolic status of the offspring even until early adulthood. |
### Instruction:
Is nRAS codon 61 mutation associated with distant metastasis in patients with follicular thyroid carcinoma?
### Response:
| The presence of a RAS mutation, especially a NRAS codon 61 mutation, was significantly associated with the distant metastasis. The NRAS codon 61 mutation status might be a potential prognostic factor in FTC patients. |
### Instruction:
Does bortezomib induce protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells?
### Response:
| In conclusion, our data here suggest that bortezomib induces protective autophagy in pancreatic and colorectal cancer cells through activating AMPK-Ulk1 signalings. AMPK or autophagy inhibitors could be developed as an adjunct or chemo-sensitizer for bortezomib. |
### Instruction:
Does high-fat and high-cholesterol diet rapidly induce non-alcoholic steatohepatitis with advanced fibrosis in Sprague-Dawley rats?
### Response:
| The HFC diet induced hepatic features of NASH and eventually progressed cirrhosis in Sprague-Dawley rats within 9 weeks. |
### Instruction:
Is tourette patients ' misbelief of a tic rebound due to overall difficulties in reliable tic rating?
### Response:
| In adults with TS, there is no tic rebound after voluntary tic suppression. Patients also reported no rebound, but erroneously felt a tic reduction in the later course of the study. This misjudgement as well as patients' often reported (mis-)belief of a tic rebound may be caused by overall difficulties in reliable tic ... |
### Instruction:
Is icotinib an active treatment of non-small-cell lung cancer : a retrospective study?
### Response:
| Icotinib is active in the treatment of patients with NSCLC both in first or second/third line, especially in those patients harbouring EGFR mutations, with an acceptable adverse event profile. |
### Instruction:
Is amygdala perfusion predicted by its functional connectivity with the ventromedial prefrontal cortex and negative affect?
### Response:
| These results show that both perfusion of the BLA and a measure of its functional coupling with the prefrontal cortex directly index anxiety levels in healthy subjects, and that low BLA-prefrontal connectivity may lead to increased BLA activity and resulting anxiety. Thus, these data provide key evidence for an often-c... |
### Instruction:
Is kISS1 receptor preferentially expressed in clinically non-functioning pituitary tumors?
### Response:
| The majority of human NFPA expressed KISS1R with lower rates of expression in other types of pituitary tumors. KISS1R expression did not impart a clinical beneficial tumor phenotype, as it was not associated with tumor size or invasiveness. Additional studies are required to elucidate the role of KISS1 receptor in pitu... |
### Instruction:
Do determination of implant position for immediate implant placement in maxillary central incisors using palatal soft tissue landmarks?
### Response:
| The root of the maxillary central incisor teeth tended to be positioning labially in the alveolar bony housing. The result of the CT analysis confirms the clinical guideline as a dependable clinical reference in immediate implant placement. |
### Instruction:
Is -94 ATTG insertion/deletion polymorphism of the NFKB1 gene associated with coronary artery disease in Han and Uygur women in China?
### Response:
| The DD genotype of the SNP (rs28362491) in the NFKB1 gene may be considered a genetic marker of CAD in Han and Uygur women in China. |
### Instruction:
Is increased C-reactive protein associated with airway wall thickness in steroid-naive asthma?
### Response:
| Serum hs-CRP may be a useful systemic biomarker of airway eosinophilia in steroid-naive asthma and has potential utility as a marker for the development of airway wall thickening. |
### Instruction:
Does cylindromatosis gene CYLD regulate hepatocyte growth factor expression in hepatic stellate cells through interaction with histone deacetylase 7?
### Response:
| Our findings highlight a novel link between CYLD and HDAC7, offering mechanistic insight into the contribution of these proteins to progression of liver disease. Thus, through regulation of HGF level, CYLD ameliorates hepatocellular damage and liver fibrogenesis. |
### Instruction:
Are activation of c-Met and upregulation of CD44 expression associated with the metastatic phenotype in the colorectal cancer liver metastasis model?
### Response:
| Taken together, our findings indicate that the aggressive metastatic phenotype of in vivo selected cell lines is associated with overexpression of CD44 and activation of c-MET. We demonstrate that c-Met activation is CD44 independent upon hepatocyte growth factor stimulation and confirm that CD44 expression in HT29 LM3... |
### Instruction:
Does intrathecal injection of the peptide myr-NR2B9c attenuate bone cancer pain via perturbing N-methyl-D-aspartate receptor-PSD-95 protein interactions in mice?
### Response:
| Intrathecal administration of Myr-NR2B9c reduced bone cancer pain. Internalization of spinal NR2B and dissociation NR2B-containing NMDARs activation from downstream nNOS signaling may contribute to the analgesic effects of Myr-NR2B9c. This approach may circumvent the negative consequences associated with blocking NMDAR... |
### Instruction:
Are elevated resistin levels associated with inflammation in hemodialysis patients with failed renal allografts?
### Response:
| Serum resistin levels are increased in HD patients with failed renal allografts very probably reflecting an allograft-induced chronic inflammatory state. |
### Instruction:
Is lifetime cumulative exposure to waterpipe smoking associated with coronary artery disease?
### Response:
| Cumulative exposure to WP smoking is significantly associated with severe CAD. There is a need to monitor WP use among cardiac patients and include this information in their medical charts in the same manner cigarettes smoking is documented. This is likely to increase awareness of the hazards of WP smoking and prompt p... |
### Instruction:
Is pain severity associated with muscle strength and peak oxygen uptake in adults with fibromyalgia?
### Response:
| The main findings from this study were that lesser values of isokinetic knee strength and peak VO2 uptake were predictive of greater pain severity scores. These results build on the findings of previous investigations, but ongoing research is needed to further characterize the effects of strength and peak VO2 uptake on... |
### Instruction:
Does methylphenidate exert dose-dependent effects on glutamate receptors and behaviors?
### Response:
| These results provide a potential mechanism underlying the cognitive-enhancing effects of low-dose MPH as well as the psychosis-inducing effects of high-dose MPH. |
### Instruction:
Do utilization of assay performance characteristics to estimate hemoglobin A1c result reliability?
### Response:
| Considerable differences in the probability of reporting unreliable Hb A(1c) results between different NGSP (formerly the National Glycohemoglobin Standardization Program)-certified platforms were observed. At a 6% TE(a), our study indicates all but the Capillarys 2 Flex Piercing requires that the maximum affordable QC... |
### Instruction:
Does a selective cyclooxygenase-2 inhibitor ( Etodolac ) prevent spontaneous biliary tumorigenesis in a hamster bilioenterostomy model?
### Response:
| Etodolac is expected to prevent secondary biliary carcinogenesis caused by persistent reflux cholangitis after bilioenterostomy. |
### Instruction:
Does eRK1/2 participate in regulating the expression and distribution of tight junction proteins in the process of reflux esophagitis?
### Response:
| TJ proteins could be used as sensitive markers of RE instead of DIS. ERK1/2 may participate in regulating TJ proteins in esophageal epithelia in RE. |
### Instruction:
Does tibial bone versican content decrease with zoledronate treatment in adult mice?
### Response:
| This is the first study to assess physiological versican and aggrecan adaptations in adult mammalian bone tissue, in the presence and absence of ZOL. We observed large decreases in some versican and aggrecan species from 12 to 24 weeks. We also observed decreases in several versican and aggrecan species in the presence... |
### Instruction:
Does thoracoscopic approach to lobectomy for lung cancer compromise oncologic efficacy?
### Response:
| The thoracoscopic approach to lobectomy for non-small cell lung cancer does not result in worse long-term survival compared with thoracotomy. |
### Instruction:
Does tumor mouse model confirm MAGE-A3 cancer immunotherapeutic as an efficient inducer of long-lasting anti-tumoral responses?
### Response:
| The recMAGE-A3+AS15 cancer immunotherapy efficiently induced an antigen-specific, functional and long-lasting immune response able to recognize and eliminate MAGE-A3-expressing tumor cells up to several months after the last immunization in mice. The data highlighted the importance of the immunostimulant to induce a Th... |
### Instruction:
Does overweight decrease the chance of achieving good response and low disease activity in early rheumatoid arthritis?
### Response:
| Overweight at diagnosis significantly decreases the chance of achieving good disease control during the early phase of RA. |
### Instruction:
Are intensive combination treatment regimens , including prednisolone , effective in treating patients with early rheumatoid arthritis regardless of additional etanercept : 1-year results of the COBRA-light open-label , randomised , non-inferiority trial?
### Response:
| Intensive COBRA or COBRA-light therapy has major, comparably favourable effects on disease activity, functional ability and radiological outcome after 1 year in patients with early RA. Protocolised addition of etanercept was often not implemented by treating rheumatologists, and patients receiving it appeared to have l... |
### Instruction:
Are state-by-state variations in cardiac rehabilitation participation associated with educational attainment , income , and program availability?
### Response:
| State-level HS graduation rates, CR programs expressed as programs per population, and median income were strongly associated with geographic variations in CR participation rates. |
### Instruction:
Is transcytosis of HIV-1 through vaginal epithelial cells dependent on trafficking to the endocytic recycling pathway?
### Response:
| Altogether, our findings demonstrate the precise intracellular trafficking pathway utilized by HIV-1 in epithelial cells, confirms that HIV-1 transcytosis through vaginal epithelial cells is a biological phenomenon and brings to light the differential intracellular trafficking of native vs heat-inactivated HIV-1 which ... |
### Instruction:
Does nrf2 promote the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy?
### Response:
| Our results provide genetic evidence that loss of autophagy in hepatocytes causes cell death resulting in liver inflammation, fibrosis and tumorigenesis. We also demonstrate that persistent activation of Nrf2 is critical for liver inflammation, fibrosis and eventual tumorigenesis that occur in mice with defects in hepa... |
### Instruction:
Does dopamine genetic risk score predict depressive symptoms in healthy adults and adults with depression?
### Response:
| Sequence variation in multiple genes regulating dopamine neurotransmission may influence depressive symptoms, in a manner that appears to be additive. Further studies are required to confirm the role of genetic variation in dopamine metabolism and depression. |
### Instruction:
Is platelet expression of stromal cell-derived factor-1 associated with the degree of valvular aortic stenosis?
### Response:
| Valvular AS is associated with enhanced platelet-SDF-1 expression; moreover the degree of valvular AS correlates with SDF-1 platelet surface expression. These findings may have clinical implications in the future. |
### Instruction:
Does genome-wide analysis reveal novel and discrete functions for tubulin carboxy-terminal tails?
### Response:
| We conclude that α- and β-CTTs play important and largely discrete roles in MT networks. β-CTT promotes MT dynamics. β-CTT also regulates force generation in the mitotic spindle by supporting kinesin-5/Cin8 and dampening dynein. Our genetic screens identify links between α- and β-CTT and additional cellular pathways an... |
### Instruction:
Is cross-sex hormone therapy in trans persons safe and effective at short-time follow-up : results from the European network for the investigation of gender incongruence?
### Response:
| Current treatment modalities were effective and carried a low risk for side effects and adverse events at short-time follow-up. |
### Instruction:
Does electroacupuncture exert an anti-inflammatory effect in a rat tissue chamber model of inflammation via suppression of NF-κB activation?
### Response:
| Collectively, our data suggest that EA inhibits the nuclear translocation of p65 and increases the expression of IκBα, which leads to the suppression of NF-κB activation in a rat tissue chamber model of inflammation. |
### Instruction:
Does [ Pidotimod inhibit activation of latent Toxoplasma gondii infection induced by dexamethasone in mice ]?
### Response:
| Pidotimod can inhibit activation of latent Toxoplasma gondii infection induced by dexamethasone in mice. Th1 and Treg cells may contribute to the pidotimod/dexamethasone-induced immunoregulation. |
### Instruction:
Are limited professional guidance and literature available to guide the safe use of neuromuscular block in infants?
### Response:
| There is a paucity of literature and professional standards to guide the safe use of NMBAs in infants. Of the 54 units who participated in the survey, only one had a protocol for using NMBAs in babies. |
### Instruction:
Does heterologous expression of an alligatorweed high-affinity potassium transporter gene enhance salinity tolerance in Arabidopsis thaliana?
### Response:
| The present study provides direct evidence that the alligatorweed K(+) transporter gene, ApKUP4, contributes to salinity tolerance in transgenic Arabidopsis seedlings, demonstrating the essentiality of potassium homeostasis for plant salinity tolerance. |
### Instruction:
Does metformin inhibit StAR expression in human endometriotic stromal cells via AMPK-mediated disruption of CREB-CRTC2 complex formation?
### Response:
| We have demonstrated a detailed mechanistic analysis of StAR expression regulated by metformin in ESCs. Our data highlight a role for CRTC2 in the mechanism by which metformin inhibits StAR expression. |
### Instruction:
Are local food environments associated with girls ' energy , sugar-sweetened beverage and snack-food intakes?
### Response:
| Girls' frequency of use of local snack-food outlets increases with the number of available types of outlets and is associated with greater daily intakes of energy and servings of SSB and snack foods/sweets. |
### Instruction:
Is preoperative anaemia associated with poor clinical outcome in non-cardiac surgery patients?
### Response:
| Anaemia is common among non-cardiac and non-neurological surgical patients, and is associated with poor clinical outcome and increased healthcare resource use. |
### Instruction:
Does inhibition of inducible nitric oxide synthesis ameliorate liver ischemia and reperfusion injury induced transient increase in arterial stiffness?
### Response:
| I/R-induced arterial stiffening was strongly associated with increased systemic inflammation. Comparable effects with treatments of 1,400W and L-NAME suggested that iNOS plays a dominant role in I/R-induced transient arterial stiffening. |
### Instruction:
Does inhibition of inducible nitric oxide synthase ameliorate myocardial ischemia/reperfusion injury - induced acute renal injury?
### Response:
| 1,400W was effective in reducing MIR-induced hemodynamic instability and kidney injury, in contrast to no apparent protection with L-NAME administration. |
### Instruction:
Does resveratrol alleviate lung ischemia and reperfusion-induced pulmonary capillary injury through modulating pulmonary mitochondrial metabolism?
### Response:
| Resveratrol treatment protects lung against I/R injury through improving mitochondrial biogenesis and reducing oxidative stress and leukocyte infiltration. |
### Instruction:
Is heart rate variability severely impaired among type 2 diabetic patients with hypertension?
### Response:
| Diabetes appears to have a greater effect on autonomic dysfunction compared with hypertension. Patients suffering from both diabetes and hypertension are at the highest risk of reduced heart rate variability. Early assessment of the autonomic nerve function is suggested in diabetic patients with hypertension. |
### Instruction:
Is hepatic steatosis highly prevalent in hepatitis B patients and negatively associated with virological factors?
### Response:
| Hepatic steatosis in HBV infected patients has been raging over the past decade, and it is negatively associated with intrahepatic expression of HBsAg. Lifestyle intervention may be needed to halt the onset of steatosis in chronic HBV infection. |
### Instruction:
Does mucosal healing predict the long-term prognosis of intestinal Behçet 's disease?
### Response:
| Our study demonstrates that MH is an independent factor predictive of long-term prognosis of intestinal BD. MH might be the ultimate therapeutic goal in the treatment of intestinal BD. |
### Instruction:
Does climbazole increase expression of cornified envelope proteins in primary keratinocytes?
### Response:
| Climbazole treatment of primary keratinocytes results in an upregulation in expression of a number of genes including those encoding proteins involved in cornified envelope formation with further studies demonstrating this did translate into increased protein expression. A climbazole-driven increase in cornified envelo... |
### Instruction:
Does attentional retraining administered in the field reduce smokers ' attentional bias and craving?
### Response:
| AR can be administered on a mobile device in the natural environment, and AR can reduce attentional bias and craving. |
### Instruction:
Does sleep deprivation potentiate HPA axis stress reactivity in healthy adults?
### Response:
| Sleep deprivation is associated with both elevated resting cortisol release and with an exaggerated cortisol response to a stressor indicative of elevated HPA axis responses in healthy adults. Individual differences in the magnitude of this response may represent a risk factor for psychological and physical health cons... |
### Instruction:
Does dysregulation of microRNA biosynthesis enzyme Dicer play an important role in gastric cancer progression?
### Response:
| Considering that Dicer might be closely related to progression of GC, we proposed that Dicer might offer a promising target for prevention of metastatic progression in GC. |
### Instruction:
Is circulating adipocyte fatty acid binding protein increased in chronic and acute renal dysfunction?
### Response:
| We show that AFABP is significantly elevated in CKD and AKD patients. Furthermore, measures of renal function are associated with circulating AFABP. Moreover, animal experiments indicate that AFABP levels strongly depend on renal function. |
### Instruction:
Are gene polymorphisms and febrile neutropenia in acute leukemia -- no association with IL-4 , CCR-5 , IL-1RA , but the MBL-2 , ACE , and TLR-4 associated with the disease in Turkish patients : a preliminary study?
### Response:
| Although TLR-4, ACE, and MBL-2 GPs have been extensively investigated in different clinical pictures, this is the first study to evaluate the role of these polymorphisms in the genetic etiopathogenesis of FN in patients with ALs. As a conclusion, TLR-4, ACE, and MBL-2 genes might play roles in the genetic etiopathogene... |
### Instruction:
Are left-sided primary tumors associated with favorable prognosis in patients with KRAS codon 12/13 wild-type metastatic colorectal cancer treated with cetuximab plus chemotherapy : an analysis of the AIO KRK-0104 trial?
### Response:
| Our findings suggest that primary tumor location and KRAS codon 12/13 mutational status interact on the outcome of patients with mCRC receiving cetuximab-based first-line therapy. Left-sided primary tumor location might be a predictor of cetuximab efficacy. |
### Instruction:
Do in vivo noninvasive measurement of skin autofluorescence biomarkers relate to cardiovascular disease in mice?
### Response:
| Cholesterol feeding induced cardiovascular disease as noted by cardiac hypertrophy in wild-type mice. A reduction was observed in pyridoxine, nicotinamide adenine dinucleotide, flavins, lipofuscin and β-carotene, which are established risk factors for cardiovascular disease. We report no significant changes in structur... |
### Instruction:
Do viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy?
### Response:
| AECs from children with wheeze and/or atopy do not have an intrinsic defect in the production of IFN-β or -λ, however, this response is influenced by the infecting virus. Higher viral load is associated with atopy and wheeze suggesting an impaired antiviral response to RSV and hMPV that is not influenced by production ... |
### Instruction:
Is use of floss/interdental brushes associated with lower risk for new cardiovascular events among patients with coronary heart disease?
### Response:
| These findings suggest that flossing and brushing of interdental spaces might reduce the risk for new cardiovascular events among patients with CHD. The hypothesis that interdental cleaning per se reduces the risk of new cardiovascular events should be examined in an interventional study. |
### Instruction:
Is the TNFSF15 gene single nucleotide polymorphism rs7848647 associated with surgical diverticulitis?
### Response:
| The SNP rs7848647 associated with the TNFSF15 gene is associated with surgical diverticulitis. This finding suggests a fundamental role for TNFSF15, a T-cell receptor gene involved in T-cell maturation, in the pathophysiology of diverticulitis requiring surgery. This SNP may be a marker of diverticular disease severity... |
### Instruction:
Does arsenic trioxide induce apoptosis of human gastrointestinal cancer cells?
### Response:
| These results demonstrate that As₂O₃ treatment in patients with gastrointestinal cancers can induce apoptosis in gastrointestinal cancer cells and down-regulate Bcl-2 protein expression. |
### Instruction:
Does 7-ketocholesteryl-9-carboxynonanoate enhance ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages?
### Response:
| These observations suggest that oxLig-1 is a novel PPARγ agonist, promoting ApoA-I-mediated cholesterol efflux from THP-1 macrophages by increasing ABCA1 expression via induction of PPARγ. |
### Instruction:
Does liarozole inhibit transforming growth factor-β3 -- mediated extracellular matrix formation in human three-dimensional leiomyoma cultures?
### Response:
| Liarozole decreased TGF-β3 and TGF-β3-mediated extracellular matrix expression in a 3D uterine leiomyoma culture system. |
### Instruction:
Does tuberculin skin testing and treatment modulate interferon-gamma release assay results for latent tuberculosis in migrants?
### Response:
| This study suggests differences in the capacity of commercially available IGRAs to identify LTBI in the absence of antecedent TST and that IGRAs, in the time periods examined, may not be the optimal tests to determine the success of chemoprophylaxis for LTBI. |
### Instruction:
Are chromosomal aneuploidies and combinational fluorescence in situ hybridization probe panels useful for predicting prognosis for esophageal squamous cell carcinoma?
### Response:
| Our data suggest that the combinational probe sets may have potential for detection and prognostic prediction of ESCC. |
### Instruction:
Is long-term use of first-line highly active antiretroviral therapy associated with carotid artery stiffness in human immunodeficiency virus-positive patients?
### Response:
| The first-line highly active antiretroviral therapy currently used in China is not associated with carotid artery stiffness in human immunodeficiency virus-positive patients with good highly active antiretroviral therapy compliance. Human immunodeficiency virus may play a role in the development of atherosclerosis. |
### Instruction:
Does clodronate inhibit tumor angiogenesis in mouse models of ovarian cancer?
### Response:
| Clodronate is a potent inhibitor of tumor angiogenesis. These results highlight clodronate as a potential therapeutic for cancer. |
### Instruction:
Does microRNA-331-3p promote proliferation and metastasis of hepatocellular carcinoma by targeting PH domain and leucine-rich repeat protein phosphatase?
### Response:
| miR-331-3p promotes proliferation and EMT-mediated metastasis of HCC through suppression of PHLPP-mediated dephosphorylation of AKT. Our work implicates miR-331-3p as a potential prognostic biomarker and a novel therapeutic target. |
### Instruction:
Do lGE and NT-proBNP identify low risk of death or arrhythmic events in patients with primary prevention ICDs?
### Response:
| Both percentage of LGE and NT-proBNP were associated with higher risk of death or appropriate ICD activation. The use of these markers in combination may be useful in identifying individuals most likely to benefit from this costly intervention, and more specifically, in the identification of a group at lower risk in wh... |
### Instruction:
Does cocoa content influence chocolate molecular profile investigated by MALDI-TOF mass spectrometry?
### Response:
| Simple sample preparation of the MALDI-TOF MS approach described will allow the surveillance and monitoring of constituents during the molecular profiling of chocolates. |
### Instruction:
Does adolescents ' school-related self-concept mediate motor skills and psychosocial well-being?
### Response:
| The study suggests that MSs is connected to PSWB in adolescent girls. Enhancement of MSs could be a preventive strategy for supporting PSWB in adolescent girls. |
### Instruction:
Does vDR status arbitrate the prometastatic effects of tumor-associated macrophages?
### Response:
| VDR suppression by TNFα mediates the prometastatic effect of TAMs through enhancement of the β-catenin pathway. |
### Instruction:
Does treatment with DPP-4 inhibitors increase the chance of pancreatitis in patients with type 2 diabetes?
### Response:
| Present analysis suggests that use of DPP-4 inhibitors is safe in patients who do not have contraindications for its use. |
### Instruction:
Is bMI associated with larger index tumors and worse outcome after radical prostatectomy?
### Response:
| Greater BMI significantly correlates with higher rates of BCR after surgery; BMI is a preoperative variable associated with high-grade ITV. Our results suggest that the biological environment created by greater BMI may contribute to increasing tumor aggressiveness. |
### Instruction:
Is loss of CD44 and SOX2 expression correlated with a poor prognosis in esophageal adenocarcinoma patients?
### Response:
| Loss of CD44 expression and loss of SOX2 expression are prognostic factors of poor survival in EAC patients. This suggests a role of these proteins in EAC that requires further investigation. |
### Instruction:
Is dNA methylation of microRNA-124a a potential risk marker of colitis-associated cancer in patients with ulcerative colitis?
### Response:
| MiR-124a genes are methylated during carcinogenesis in UC patients. The methylation level of miR-124a-3 is a promising marker for estimating individual risk for CAC. |
### Instruction:
Does anti-prokineticin1 ( PROK1 ) monoclonal antibody suppress angiogenesis and tumor growth in colorectal cancer?
### Response:
| The in vitro and vivo experimental system indicated that the anti-PROK1mAb could suppress angiogenesis and tumor growth in the CRC strains. |
### Instruction:
Does melatonin influence on steroidogenic gene expression in the ovary of pinealectomized rats?
### Response:
| Melatonin deprivation (pinealectomy) or administration may influence the ovarian CYP17A1 expression and steroidogenesis. |
### Instruction:
Does dexamethasone reduce length of hospitalization or recurrent wheezing 1 year after early bronchiolitis?
### Response:
| High dose dexamethasone or medium-dose prednisolone during AB provided no benefit in a short or long-term period in young, previously healthy hospitalized infants. |
### Instruction:
Do platelets provoke distinct dynamics of immune responses by differentially regulating CD4+ T-cell proliferation?
### Response:
| Platelets constantly promote Treg cell response but exert a biphasic regulation on Th1/Th17 activation, namely a transient enhancement followed by a secondary suppression. The distinct regulations are achieved by transforming growth factor β-mediated selective inhibition of FoxP3(-) T-cell proliferation. This represent... |
### Instruction:
Does polyphenol-rich bilberry ameliorate total cholesterol and LDL-cholesterol when implemented in the diet of Zucker diabetic fatty rats?
### Response:
| Bilberry consumption ameliorated total and LDL-cholesterol levels, but not HDL-cholesterol levels in ZDF rats. Neither bilberry nor blackcurrant enrichment delayed the development of diabetes or hypertension. Thus, in rats, bilberries may be valuable as a dietary preventive agent against hypercholesterolemia, probably ... |
### Instruction:
Does expression of HPV-16 E6 protein and p53 inactivation increase the uterine cervical cancer invasion?
### Response:
| The association of HPV infection and E6 expression increases the risk of cervical cancer. Further, E6 expression is the cause for inactivation of p53 in tumor tissues and deregulated cell proliferation and thus favors for tumor invasion. |
### Instruction:
Is atrial fibrillation associated with different levels of physical activity levels at different ages in men?
### Response:
| Leisure-time exercise at younger age is associated with an increased risk of AF, whereas walking/bicycling at older age is associated with a decreased risk. |
### Instruction:
Is cytotoxic effects of human calprotectin on gastric cancer cell line attenuated by etoposide?
### Response:
| The result indicates that, the combination of both calprotectin and etoposide is considerably less cytotoxic on gastric cancer cells (AGS) than applying individually. |
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