question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Does aldehyde dehydrogenase 1 ( ALDH1 ) positivity correlate with poor prognosis in cervical cancer?
### Response:
| ALDH1 positivity is associated with poor prognosis of cervical carcinoma, and may be an independent predictor of prognosis. |
### Instruction:
Is serum cystatin-C superior to serum creatinine in predicting glomerular filtration rate in cirrhotic patients?
### Response:
| Neither serum creatinine nor Cystatin-C are good predictors of GFR in cirrhoticpatients, although serum creatinine seems to perform better in selectedsubgroups. |
### Instruction:
Do [ Anterior revision surgery for the treatment of cervical spondylosis after anterior decompression and titanium mesh fusion ]?
### Response:
| After surgery of cervical decompression and bone graft fusion with titanium mesh, the patients need re-operation because of incomplete decompression, degenerative changes in adjacent segments or newly formed compression factors, and complications caused by implants. Anterior revision surgery can obtain good clinical ef... |
### Instruction:
Is chemoradiotherapy with taxane superior to conventional surgery and radiotherapy in the management of cutaneous angiosarcoma : a multicentre , retrospective study?
### Response:
| From these results, we suggest that T + RT followed by maintenance chemotherapy is a plausible method for managing CAS, especially large tumours that are difficult to manage with S + RT alone. |
### Instruction:
Do hepG2 cells mount an effective antiviral interferon-lambda based innate immune response to hepatitis C virus infection?
### Response:
| HepG2-HFL cells represent a new system to study the interaction between HCV and the innate immune system, solidifying the importance of IFN-λ in hepatic response to HCV infection and revealing non-redundant roles of RIG-I and melanoma differentiation-associated protein 5 in HCV recognition and repression of infection. |
### Instruction:
Is prevalence of bloodstream pathogens higher in neonatal encephalopathy cases vs. controls using a novel panel of real-time PCR assays?
### Response:
| This real-time PCR panel detected more bacteremia than culture alone and provides a novel tool for detection of neonatal bloodstream pathogens that may be applied across a range of clinical situations and settings. Significantly more encephalopathic infants than controls had pathogenic bacterial species detected sugges... |
### Instruction:
Is eating two larger meals a day ( breakfast and lunch ) more effective than six smaller meals in a reduced-energy regimen for patients with type 2 diabetes : a randomised crossover study?
### Response:
| Eating only breakfast and lunch reduced body weight, HFC, fasting plasma glucose, C-peptide and glucagon, and increased OGIS, more than the same caloric restriction split into six meals. These results suggest that, for type 2 diabetic patients on a hypoenergetic diet, eating larger breakfasts and lunches may be more be... |
### Instruction:
Do children with asthma have significantly lower long-term cortisol levels in their scalp hair than healthy children?
### Response:
| Long-term cortisol levels were significantly lower in children with asthma than healthy children. Measuring long-term cortisol levels in scalp hair is an attractive, noninvasive tool that can evaluate the effect of asthma and its treatment on the hypothalamic-pituitary-adrenal axis. |
### Instruction:
Does microRNA-27a modulate HCV infection in differentiated hepatocyte-like cells from adipose tissue-derived mesenchymal stem cells?
### Response:
| Our results demonstrate that AT-hMSCs are a good source of DHCs, which are suitable for in vitro cultivation of HCV. Furthermore, these results suggest that miR-27a modulates HCV infectivity by regulating LDLR expression. |
### Instruction:
Is diabetes mellitus an independent prognostic factor for major liver-related outcomes in patients with cirrhosis and chronic hepatitis C?
### Response:
| In patients with CHC and cirrhosis, diabetes is an independent prognostic factor. Improving diabetes control may improve the outcome of cirrhosis. |
### Instruction:
Does intra-articular mepivacaine reduce interventional analgesia requirements during arthroscopic surgery in dogs?
### Response:
| Intra-articular mepivacaine blunts the haemodynamic response to arthroscopic surgery in dogs and reduces interventional analgesia requirement. |
### Instruction:
Are peripheral B-cell phenotype and BAFF levels associated with HLA immunization in patients awaiting kidney transplantation?
### Response:
| Increased proportions of activated naive B cells are linked with pretransplant HLA immunization and the development of posttransplant donor-specific antibodies. |
### Instruction:
Are inflammatory adverse events associated with disease-free survival after vaccine therapy among patients with melanoma?
### Response:
| IAE are associated with a higher rate of CD8(+) T cell response after vaccination therapy for high-risk melanoma. Our findings suggest either that antitumor activity induced by class I MHC-restricted peptide vaccines may depend on immunologic effects beyond simple expansion of CD8(+) T cells or that the intrinsic infla... |
### Instruction:
Do atypical Anterior Spinal Artery Infarction due to Left Vertebral Artery Occlusion Presenting with Bilateral Hand Weakness?
### Response:
| Bilateral or unilateral hand weakness can be the sole symptom of a cervical cord infarct. |
### Instruction:
Is fragility a key determinant of survival in heart failure patients?
### Response:
| Fragility is a key determinant of survival in ambulatory patients with HF across all age strata. |
### Instruction:
Are increased uptake and new therapies needed to avert rising hepatitis C-related end stage liver disease in England : modelling the predicted impact of treatment under different scenarios?
### Response:
| If the infected population is left untreated, the number of patients with severe HCV-related disease will continue to increase and represent a substantial future burden on healthcare resources. This can be mitigated by increasing treatment uptake, which will have the greatest impact if implemented quickly. |
### Instruction:
Do urinary metabolite profiles in premature infants show early postnatal metabolic adaptation and maturation?
### Response:
| This first nutri-metabolomics study in premature infants demonstrates that the physiological adaptation during the fetal-postnatal transition as well as maturation influences metabolism during the breastfeeding period. Elevated glycine and threonine levels were found in the first week urine samples of the SGA infants a... |
### Instruction:
Are oSA and depression common and independently associated with refractory angina in patients with coronary artery disease?
### Response:
| OSA and depression are independently associated with refractory angina and may contribute to poor cardiovascular outcome. |
### Instruction:
Do [ Failure analysis as basis for quality assurance strategies in implant technology ]?
### Response:
| The increased level of knowledge gained from complex analyses of failed implants produces valuable evidence for better quality management. |
### Instruction:
Is lack of RAAS inhibition by high-salt intake associated with arterial stiffness in hypertensive patients?
### Response:
| We showed a) an inverse salt-RAAS relation, b) an association between HS plus high RAAS with increased PWV that could identify a higher-risk hypertensive condition. |
### Instruction:
Do benzodiazepine site agonists differentially alter acetylcholine release in rat amygdala?
### Response:
| ACh release in the amygdala was decreased by IV delivery of midazolam and eszopiclone. Dialysis delivery directly into the amygdala caused either increased (eszopiclone and diazepam) or likely no significant change (midazolam and zolpidem) in ACh release. These contrasting effects of delivery route on ACh release suppo... |
### Instruction:
Is increased burden of inflammation over time associated with the extent of atherosclerotic plaques in patients with psoriatic arthritis?
### Response:
| Exposure to an increased burden of inflammation is associated with more severe atherosclerosis in patients with PsA. This association may be mediated by traditional cardiovascular risk factors. |
### Instruction:
Does elmo1 help dock180 to regulate Rac1 activity and cell migration of ovarian cancer?
### Response:
| Engulfment and cell motility 1 presents with synergetic action in helping Dock180 to activate Rac1 and promote cell motility, and thus promote untoward expansion and aggressiveness of SOC. |
### Instruction:
Do women with pre-gestational diabetes have a higher risk of stillbirth at all gestations after 32 weeks?
### Response:
| Women with diabetes have a significantly higher risk of stillbirth at all gestations after 32 weeks and this additional risk is not just confined to pregnancies at 37 weeks or more. |
### Instruction:
Are anti-proliferative and anti-tumour effects of lymphocyte-derived microparticles neither species- nor tumour-type specific?
### Response:
| These results highlight the potential role of LMPs in modulating the growth of high proliferating cells. Given that cell-based therapies are considered less toxic than pharmacologic approaches and have the potential to target multiple pathways in a synergistic manner, LMPs may serve as a veritable option for cancer tre... |
### Instruction:
Does postoperative radiation boost improve local recurrence rates in extremity soft tissue sarcomas?
### Response:
| No differences in rates of local recurrence, distant metastasis or death due to sarcoma were found in patients who received both pre- and postoperative radiotherapy when compared with those who received only preoperative radiotherapy. |
### Instruction:
Is metformin associated with reduced risk of pancreatic cancer in patients with type 2 diabetes mellitus : a systematic review and meta-analysis?
### Response:
| From present observational studies, use of metformin appears to be associated with a reduced risk of pancreatic cancer in patients with T2DM. Further investigation is needed. |
### Instruction:
Is adolescent male hazardous drinking and participation in organised activities : involvement in team sports associated with less hazardous drinking in young offenders?
### Response:
| Although young offenders were less likely to have participated in organised activities, for them, participation in a team sport was associated with less hazardous drinking. Vulnerable youths who might benefit most from sporting activities actually access them the least. Future research should identify the different bar... |
### Instruction:
Does pretreatment of transfused donor splenocytes and allografts with mitomycin C attenuate acute rejection in heart transplantation in mice?
### Response:
| Both injection of MMC-conditioned donor splenocytes and MMC-conditioned allograft have effects on prolongation of heart allograft survival in mice, and MMC-conditioned donor splenocytes might play an essential role. MMC pretreatment induced regulatory T cells likely through induction of donor splenocyte apoptosis, and ... |
### Instruction:
Is frequent video-game playing in young males associated with central adiposity and high-sugar , low-fibre dietary consumption?
### Response:
| These preliminary results identify frequent video-game playing as an important lifestyle behaviour which may have important implications for understanding obesity risk in young male adults. |
### Instruction:
Does family-based association analysis of alcohol dependence implicate KIAA0040 on Chromosome 1q in multiplex alcohol dependence families?
### Response:
| Family-based association analysis shows the KIAA0040 gene significantly associated with alcohol dependence. The potential importance of the KIAA0040 gene for AD risk is currently unknown. However, the present results support earlier findings from a genome-wide association study. |
### Instruction:
Is obesity associated with reduced disc height in the lumbar spine but not at the lumbosacral junction?
### Response:
| Obesity was associated with reduced disc height in the lumbar spine, but not at the lumbosacral junction, suggesting these joints may have different risk factors. There was also evidence for an inter-relationship between obesity, lumbar disc height, and recent pain, suggesting that structural changes have a role in bac... |
### Instruction:
Does effect that an educational program for cystic fibrosis patients and caregivers have on the contamination of home nebulizers?
### Response:
| In our sample of CF patients, nebulizer contamination was common, indicating the need for improvement in patient practices regarding the cleaning and disinfection of their nebulizers. A one-time educational intervention could have a significant positive impact. |
### Instruction:
Does histone deacetylase inhibitor treatment increase coronary t-PA release in a porcine ischemia model?
### Response:
| These findings support a proof of concept for histone deacetylation inhibition positive effect on tissue plasminogen activator expression in an in vivo setting. Further studies are needed to find an optimal way to implement histone deacetylation inhibition to achieve desired clinical changes in tissue plasminogen activ... |
### Instruction:
Is jNK-dependent downregulation of FoxO1 required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis?
### Response:
| Our findings identify JNK-dependent modulation of mRNA stability as an important PKB-independent mechanism underlying FoxO1 regulation by cytokines, and suggest that reduced FoxO1 expression is required to promote FLS survival in RA. |
### Instruction:
Does chemotherapy mediate intestinal injury via p53/p53 upregulated modulator of apoptosis ( PUMA ) signaling pathway?
### Response:
| Chemotherapy might mediate intestinal injury via p53/PUMA-mediated apoptotic signaling and the suppression of proliferation in response to p21. |
### Instruction:
Is physical activity associated with decreased incidence of chronic kidney disease in type 2 diabetes patients : a retrospective cohort study in Taiwan?
### Response:
| In this study, physical activity was not only a healthful lifestyle factor but also a treatment to decrease incidence of chronic kidney disease in diabetic patients. |
### Instruction:
Are group M consensus Gag and Nef peptides as efficient at detecting clade A1 and D cross-subtype T-cell functions as subtype-specific consensus peptides?
### Response:
| These data support the use of consensus group M overlapping peptide sets as reagents for detecting HIV-specific responses in a clade A and D infected population, but underscore the limitations of utilizing these reagents when evaluating the breadth of virus-specific responses. |
### Instruction:
Is smoking cessation followed by increases in serum bilirubin , an endogenous antioxidant associated with lower risk of lung cancer and cardiovascular disease?
### Response:
| Smoking cessation is followed by increases in bilirubin concentration that have been associated with lower risk of lung cancer and cardiovascular disease. |
### Instruction:
Does mRI detect acetabular osteolysis around metal-on-metal Birmingham THA?
### Response:
| There is no evidence in the literature to support the effectiveness of MARS MRI to detect periacetabular osteolysis around cobalt chromium alloy metal-on-metal total hip arthroplasties. Osteolysis due to corrosion-related particles seems to be one of the primary modes of failure in modular MoM THA. |
### Instruction:
Are less experience and running pace potential risk factors for medical complications during a 56 km road running race : a prospective study in 26 354 race starters -- SAFER study II?
### Response:
| Less experience and running at either a slow or a fast pace were risk factors for complications during 56 km road running. Annual variation may also affect risk. Risk factors for specific medical complications were also identified. These data form the basis of further studies to assist medical staff to plan appropriate... |
### Instruction:
Does postoperative but not preoperative treatment with sorafenib inhibit liver regeneration in rats?
### Response:
| In our rat model, Sorafenib did not increase posthepatectomy mortality. Postoperative treatment significantly impaired liver regeneration. Preoperative treatment impaired body weight during the gavage period, but was without effect on liver regeneration. |
### Instruction:
Is counseling for fetal macrosomia : an estimated fetal weight of 4,000 g excessively low?
### Response:
| The policy of discussing the risk of macrosomia with SEFW ≥ 4,000 g to women is not justified. A higher SEFW to trigger counseling for shoulder dystocia and CS, more consistent with American College of Obstetrics and Gynecology (ACOG) guidelines, should be considered. |
### Instruction:
Does rab4 orchestrate a small GTPase cascade for recruitment of adaptor proteins to early endosomes?
### Response:
| Together these findings indicate that Arl1 links Rab4-dependent formation of endosomal sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal sorting machinery. |
### Instruction:
Does pTEN mediate the antioxidant effect of resveratrol at nutritionally relevant concentrations?
### Response:
| Resveratrol acts as an antioxidant at nutritionally relevant concentrations by inducing the expression of antioxidant enzymes, through a mechanism involving PTEN/Akt signaling pathway. |
### Instruction:
Are straight proximal humeral nails surrounded by more bone stock in comparison to bent nails in an experimental cadaveric study?
### Response:
| Based on the volumetric data a statistically relevant biomechanical superiority of straight shaped implants can be assumed. Since we found a rapid decrease of bone density in cranio-caudal direction, intramedullary implants should be anchored as proximally in the subcortical area as possible to minimize the risk of dis... |
### Instruction:
Is an adverse lipid profile associated with disability and progression in disability , in people with MS?
### Response:
| In this prospective population-based cohort study, an adverse lipid profile was associated with high levels of MS disability and disease progression. Improving serum lipids may be beneficial for MS patients, to potentially improve clinical outcomes and vascular comorbidities. |
### Instruction:
Does normalization reduce intersubject variability in cervical vestibular evoked myogenic potentials?
### Response:
| Normalization significantly reduces cVEMP intersubject variability in healthy subjects without altering cVEMP characteristics. By reducing cVEMP amplitude variation due to nonsaccular, muscle-related factors, cVEMP normalization is expected to improve the ability to distinguish between healthy and pathologic responses ... |
### Instruction:
Do pTEN-deficient tumors depend on AKT2 for maintenance and survival?
### Response:
| Depletion of AKT2, but not AKT1, induces potent tumor regression in PTEN-deficient prostate cancer xenografts, concomitant with upregulation of p21, which may serve as a potential biomarker for screening AKT2 activity in clinical samples. The specific role of AKT2 in tumor maintenance provides a rationale for the devel... |
### Instruction:
Are children under the age of two more likely to watch inappropriate background media than older children?
### Response:
| Young children under the age of two frequently watch background media that has age-inappropriate content or has not been turned on for them to watch. |
### Instruction:
Is insulin resistance an independent predictor of severe lower urinary tract symptoms and of erectile dysfunction : results from a cross-sectional study?
### Response:
| IR patients are at high risk of having severe LUTS and contemporary sexual dysfunctions. We strongly suggest to prevent LUTS and ED by reducing insulin resistance. |
### Instruction:
Does comprehensive reference range for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults?
### Response:
| Hematological and Clinical Chemistry reference ranges established in this study showed significant gender differences. Pregnant women also differed from non-pregnant females and during pregnancy. This is the first of such comprehensive study to establish reference values among adult Nigerians and difference observed un... |
### Instruction:
Does insulin therapy improve islet functions by restoring pancreatic vasculature in high-fat diet-fed streptozotocin-diabetic rats?
### Response:
| The results suggest that insulin treatment improves islet recovery by increasing angiogenesis in the pancreas. The mechanism is related to the induction of VEGF and VEGFR2 expression in diabetic rats. |
### Instruction:
Are high-sensitivity troponin I concentrations a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis?
### Response:
| In patients with aortic stenosis, plasma cTnI concentration is associated with advanced hypertrophy and replacement myocardial fibrosis as well as AVR or cardiovascular death. |
### Instruction:
Is programmed death-1 gene polymorphism ( PD-1.5 C/T ) associated with gastric cancer?
### Response:
| These results suggest that PD-1.5 C/T polymorphism may affect the GC risk and prognosis in an Iranian population. |
### Instruction:
Is left atrial volume superior to the ratio of the left atrium to aorta diameter for assessment of the severity of patent ductus arteriosus in extremely low birth weight infants?
### Response:
| This study provided appropriate BSA correction of LAV and its reference values in ELBWIs. LAV indices may be superior to LA/Ao for PDA severity assessment. Measurement of single-plane LAV is easy, with similar usefulness to biplane LAV. |
### Instruction:
Does upper limit of vulnerability during defibrillator implantations predict the occurrence of appropriate shock therapy for ventricular fibrillation?
### Response:
| A high ULV value was associated with a high incidence of VF, which suggests that cardiac vulnerability to electrical shock may be linked to electrical instability. |
### Instruction:
Does parental stress predict functional outcome in pediatric cancer survivors?
### Response:
| Although children demonstrated both neurocognitive deficits and functional impairments, results favor psychosocial factors, such as parental stress, as a predictor of overall functional impairment. The implications of this study suggest that late effects aggregate to impact day-to-day functioning in pediatric cancer su... |
### Instruction:
Does rapid Short MRI Sequence Useful in Eliminating Stroke mimic Among Acute Stroke Patients Considered for Intravenous Thrombolysis?
### Response:
| In patients with acute stroke-like symptoms, BAT MRI may be used to confirm acute ischemic stroke, exclude stroke mimics, and assess candidacy for IV-tPA. |
### Instruction:
Is lymphocytic gastritis associated with active Helicobacter pylori infection?
### Response:
| LG is not a distinct clinicopathologic entity, but a morphologic pattern of gastric injury that can be secondary to a variety of underlying etiologies. When restricted to cases with lymphocytosis alone, LG is strongly associated with CD and not with active H. pylori infection. However, cases that also show significant ... |
### Instruction:
Does [ Overexpression of integrin-linked kinase improve cardiac function in a rat model of doxorubicin-induced chronic heart failure ]?
### Response:
| ILK gene therapy improves cardiac function in this rat model of heart failure, and is associated with reduced apoptosis and increased cardiomyocyte proliferation. |
### Instruction:
Is liver stiffness assessed by acoustic radiation force impulse ( ARFI ) technology considerably increased in patients with cholestasis?
### Response:
| Cholestasis significantly increases liver stiffness assessed by ARFI. Therefore, it is important to exclude profound cholestasis when using ARFI for evaluating patients for liver fibrosis. |
### Instruction:
Is impact of CYP2C19 polymorphism on clinical outcome following coronary stenting more important in non-diabetic than diabetic patients?
### Response:
| The impact of CYP2C19 polymorphism on clinical outcome seems to be more significant in non-DM compared with DM in patients with coronary stents. |
### Instruction:
Does toll-like receptor triggering augment activation of human mast cells by anti-citrullinated protein antibodies?
### Response:
| Our data show that synovial mast cells express FcγRIIA and that mast cells can be activated by IgG-ACPA and TLR ligands. Importantly, combined stimulation via TLRs and immune complexes leads to synergy in cytokine production. These findings suggest mast cells are important targets for TLR ligands and immune complexes, ... |
### Instruction:
Does microRNA-21 regulate hTERT via PTEN in hypertrophic scar fibroblasts?
### Response:
| These data indicate that miR-21 regulates hTERT expression via the PTEN/PI3K/AKT signaling pathway by directly targeting PTEN, therefore controlling hypertrophic scar fibroblast cell growth. MiR-21 may be a potential novel molecular target for the treatment of hypertrophic scarring. |
### Instruction:
Do improvements on neuromuscular performance with caffeine ingestion depend on the time-of-day?
### Response:
| The ingestion of a moderate dose of caffeine counteracts the muscle contraction velocity declines observed in the morning against a wide range of loads. Caffeine effects are more evident in the lower body musculature. Evening caffeine ingestion not only has little effect on neuromuscular performance, but increases the ... |
### Instruction:
Do cD70-expressing CD4 T cells produce IFN-γ and IL-17 in rheumatoid arthritis?
### Response:
| CD70(+) CD4 T cells are enriched in RA and may directly contribute to RA pathogenesis by producing IFN-γ and IL-17. Targeting CD70(+) CD4 T cells might offer new therapeutic opportunities in RA. |
### Instruction:
Does the feasibility and impact of midnight routine blood draw on laboratory orders and processing time?
### Response:
| Midnight is a feasible alternative for the timing of routine blood draws. Redesigning inflow of laboratory orders improved efficiency of laboratory processing and reduced stat orders. |
### Instruction:
Does aspirin but not meloxicam attenuate early atherosclerosis in apolipoprotein E knockout mice?
### Response:
| These results suggest that low dose aspirin reduces early atherosclerosis, while inhibition of COX-2 by meloxicam is not associated with an increase in atherosclerotic plaque size in this mouse model. |
### Instruction:
Does implementation of bundled interventions greatly decrease deep sternal wound infection following cardiovascular surgery?
### Response:
| Complete implementation of simple multidisciplinary prevention measures as a bundle can greatly decrease the incidence of DSWI. |
### Instruction:
Does whole exome sequencing identify CRB1 defect in an unusual maculopathy phenotype?
### Response:
| This report illustrates a novel presentation of a macular dystrophy caused by CRB1 mutations. Both affected siblings exhibited a relatively well-developed retinal structure and preservation of generalized retinal function. An unusual 5-year progression of macular atrophy alone was observed that has not been described i... |
### Instruction:
Is gestational diabetes mellitus in twin pregnancies associated with adverse perinatal outcomes?
### Response:
| In our population, GDM in twin pregnancies was not associated with increased rates of adverse perinatal outcomes. In addition, GDM was not found to be an independent risk factor for CD in twin pregnancies. |
### Instruction:
Does vasopressin improve hemodynamic status in infants with congenital diaphragmatic hernia?
### Response:
| Vasopressin stabilized systemic hemodynamics without adverse effects on pulmonary hemodynamics in a subset of infants with CDH. Our results suggest a potential role for vasopressin therapy in patients with CDH with catecholamine-resistant refractory hypotension. |
### Instruction:
Is noninvasive evaluation of swallowing sound an effective way of diagnosing feeding maturation in newborn infants?
### Response:
| Swallowing sound can be used to assess feeding maturation in preterm infants during neonatal intensive care unit follow-up. |
### Instruction:
Does cBRH-7919 cell supernate promote fibroblasts to express cyclooxygenase-2 and hepatocyte growth factor?
### Response:
| Fibroblasts can be activated by CBRH-7919 cell supernate. Activated fibroblasts can express COX-2 and HGF at higher levels. Maybe we can take advantage of the activated fibroblasts to promote the neovascularization and proliferation of transplanted liver cells. |
### Instruction:
Does low-level laser therapy prevent prodromal signal complications on saphenectomy post myocardial revascularization?
### Response:
| LLLT was valuable in preventing prodromal complications in saphenectomy post myocardial revascularization. |
### Instruction:
Do leptin level and oxidative stress contribute to obesity-induced low testosterone in murine testicular tissue?
### Response:
| Pathological damage of Leydig cells, oxidative stress in testis tissue, and high level of leptin may provide some evidence to clarify the mechanisms of male SH in obesity. |
### Instruction:
Is a multitiered strategy of simulation training , kit consolidation , and electronic documentation associated with a reduction in central line-associated bloodstream infections?
### Response:
| Combined simulation training, standardized all-inclusive kits, and EMR-guided documentation were associated with greater documented compliance with sterile precautions and reduced CLABSI rate in our MICU. To achieve maximal benefit, refresher training of senior physicians supervising practice at the bedside may be need... |
### Instruction:
Do prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months -- a differential susceptibility model?
### Response:
| Children with S or LG alleles, when exposed to prenatal depression, have higher levels of dysregulation, and when exposed to lower or little prenatal depression, have higher capacity for regulation. Our findings support efforts to identify, support and treat prenatal depression. |
### Instruction:
Does nOS3 tagSNPs modify the chronic kidney disease progression in autosomal dominant polycystic kidney disease?
### Response:
| Our data suggests that there is no evidence for the involvement of NOS3 tag SNPs in the progression to CKD in ADPKD patients. A systematic study using well validated functional SNPs is necessary to clarify the role of the NOS3 gene in the development of CKD in ADPKD. |
### Instruction:
Do invasion and proliferation kinetics in enhancing gliomas predict IDH1 mutation status?
### Response:
| The strong correlation between IDH1 mutation status and the MRI-based invasion profile suggests that use of our tumor growth model may lead to noninvasive clinical detection of IDH1 mutation status and thus lead to better treatment planning, particularly prior to surgical resection, for contrast-enhancing gliomas. |
### Instruction:
Is sustained neuronal hyperexcitability evident in the thalamus after a transient cervical radicular injury?
### Response:
| These data demonstrate that persistent radicular pain is associated with sustained neuronal hyperexcitability in the contralateral VPL of the thalamus. These findings suggest that thalamic processing is altered during radiculopathy and these changes in neuronal firing are associated with behavioral sensitivity. |
### Instruction:
Does faecal metabolite profiling identify medium-chain fatty acids as discriminating compounds in IBD?
### Response:
| Faecal metabolic profiling in patients with IBD relative to healthy controls identified MCFAs as important metabolic biomarkers of disease-related changes. |
### Instruction:
Is pulmonary hypertension in patients with advanced heart failure associated with increased levels of interleukin-6?
### Response:
| Inflammatory biomarkers correlate to PH severity. IL-6 predicts sPAP in advanced HF. |
### Instruction:
Are age at first childbirth and oral contraceptive use associated with risk of androgen receptor-negative breast cancer : the Malmö Diet and Cancer Cohort?
### Response:
| Advanced age at first child birth and use of oral contraceptives were associated with increased risk of AR(-) breast cancer. This study may contribute to enhanced understanding of the role of the AR in breast carcinogenesis and improve risk stratification tools for personalized breast cancer prevention. |
### Instruction:
Is proton pump inhibitor use associated with spontaneous bacterial peritonitis in patients with liver cirrhosis?
### Response:
| The use of PPIs in cirrhotic patients with ascites is independently associated with SBP in the Japanese clinical setting. |
### Instruction:
Does high-frequency ventilation provide mortality benefit in comparison with conventional lung-protective ventilation in acute respiratory distress syndrome : a meta-analysis of the randomized controlled trials?
### Response:
| HFOV should not be used routinely in all adult patients with acute respiratory distress syndrome as primary ventilation strategy in place of conventional lung-protective ventilation. |
### Instruction:
Does rosiglitazone attenuate atrial structural remodeling and atrial fibrillation promotion in alloxan-induced diabetic rabbits?
### Response:
| Rosiglitazone attenuates arrhythmogenic atrial structural remodeling and AF promotion in alloxan-induced diabetic rabbits. Also, it seems to modulate oxidative stress and inflammation in this experimental model. |
### Instruction:
Is induction of liver cytochrome P450s by Danshen-Gegen formula the leading cause for its pharmacokinetic interactions with warfarin?
### Response:
| Collectively, current study demonstrated that DGF could significantly induce the liver phase I metabolism of warfarin, and to a less extent, potentially increase the intestinal absorption and decrease the plasma protein binding of warfarin. The inductive effects of DGF on the liver phase I metabolism of warfarin may be... |
### Instruction:
Is `` It my destiny as a woman '' : on becoming a new mother in Indonesia?
### Response:
| This study provides nurses and others with insights into the experiences of Indonesian women with early motherhood, their feelings about taking on the mothering role, and some of their needs during this period. |
### Instruction:
Does mifepristone-inducible recombinant adenovirus attenuate paraquat-induced lung injury in rats?
### Response:
| RU486-induced overexpression of NRF2 in lungs transfected with Ad-RUNRF2 can ameliorate PQ-induced lung injury by the activation of the NRF2-antioxidant response element (ARE) pathway. |
### Instruction:
Does baseline KL-6 predict increased risk for acute exacerbation of idiopathic pulmonary fibrosis?
### Response:
| Baseline serum KL-6 level is a sensitive predictor for the onset of AE in IPF. |
### Instruction:
Does interleukin-6 induce neuroendocrine differentiation ( NED ) through suppression of RE-1 silencing transcription factor ( REST )?
### Response:
| These results demonstrate that REST functions as a major switch of IL-6 induced neuroendocrine differentiation in LNCaP cells. |
### Instruction:
Does astaxanthin from shrimp by-products ameliorate nephropathy in diabetic rats?
### Response:
| Our results suggest that shrimp astaxanthin may play an important role in reduction of oxidative damage and could prevent pathological changes in diabetic rats suggesting promising application of shrimp astaxanthin in diabet treatment. |
### Instruction:
Do delayed bone healing following high tibial osteotomy related to increased implant stiffness in locked plating?
### Response:
| These results support the hypothesis that low bone formation underneath locking plates is induced by increased stiffness. This high stiffness situation could be altered by replacing the standard screws with dynamic screws which allow for a movement of 0.35mm perpendicular to the screw axis. This resulted in an approxim... |
### Instruction:
Do lMO7-null mice exhibit phenotypes consistent with emery-dreifuss muscular dystrophy?
### Response:
| These findings demonstrate that loss of Lmo7 in mice causes myopathic phenotypes similar to those seen in other EDMD mouse models. |
### Instruction:
Does femoral nerve block for acute postoperative pain after knee replacement surgery?
### Response:
| Following TKR, FNB (with or without concurrent treatments including PCA opioid) provided more effective analgesia than PCA opioid alone, similar analgesia to epidural analgesia and less nausea/vomiting compared with PCA alone or epidural analgesia. The review also found that continuous FNB provided better analgesia com... |
### Instruction:
Does prognostic marker microRNA-125b inhibit tumorigenic properties of hepatocellular carcinoma cells via suppressing tumorigenic molecule eIF5A2?
### Response:
| This study has evidenced for the negative correlation of tumor miR-125b expression with poor prognosis of HCC patients. Expression of miR-125b can reverse the tumorigenic properties of cultured HCC cells via suppressing the tumorigenic molecule eIF5A2, thus postulating restoration of miR-125b level as a way to countera... |
### Instruction:
Is robot-assisted rectopexy a safe and feasible option for treatment of rectal prolapse?
### Response:
| Robot-assisted rectopexy is a safe procedure for patients with rectal prolapse and is associated with acceptable functional outcomes and recurrence rates. There is no evidence in the literature of advantages compared with the corresponding laparoscopic procedure. |
### Instruction:
Are leakage and internal herniation the most common complications after gastric bypass?
### Response:
| In conclusion, the primary early complication of LRYGB patients was leakage, and internal hernia was the most frequent late complication. A substantial number of the patients who are readmitted after LRYGB suffer from unexplained abdominal pain that should be managed by specialised centres. |
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