question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Does resistance exercise increase postprandial muscle protein synthesis in humans?
### Response:
| We conclude that resistance-type exercise performed in a fed state further elevates postprandial muscle protein synthesis rates, which is accompanied by an increase in S6 and 4E-BP1 phosphorylation state. |
### Instruction:
Is exercise capacity in the heat greater in the morning than in the evening in man?
### Response:
| The results of this study suggest that endurance exercise capacity in the heat was significantly greater in the morning than the evening, possibly due to a lower initial Tc. |
### Instruction:
Do development and validation of a model for prediction of mortality in patients with acute burn injury?
### Response:
| An accurate model was developed to predict the probability of death from acute burn injury based on simple and objective clinical criteria. |
### Instruction:
Does eNOS T-786C polymorphism affect atorvastatin-induced changes in erythrocyte membrane fluidity?
### Response:
| These findings suggest that a short treatment with atorvastatin is disadvantageous to subjects with the CC genotype for the T-786C polymorphism compared to those with TT genotype, at least in terms of the hemorheological properties of erythrocytes. |
### Instruction:
Does thrombin induce broad spectrum proteolysis in human serum samples?
### Response:
| The resulting peptides indicate broad tolerance beyond the consensus R-G cleavage site of fibrinogen; in fact, there appears to be no bias for the amino acid following the R/K residue. These data support our hypothesis that the enzymatic activities inherent to coagulation, or at least to thrombin, contribute to destabilization of the protein and peptide content of serum. |
### Instruction:
Does rapid pressure compensation by automated cuff pressure controllers worsen sealing in tracheal tubes?
### Response:
| Automated cuff pressure controllers with rapid pressure correction interfere with the self-sealing mechanism of high sealing HVLP tube cuffs and reduce their improved sealing characteristics. |
### Instruction:
Are anxiety and poor social support independently associated with adverse outcomes in patients with mild heart failure?
### Response:
| Anxiety and low social support were independently associated with HF-related re-admission, which indicates the need for their inclusion in the assessment and management of HF. |
### Instruction:
Does plasma from preeclamptic women stimulate transendothelial migration of neutrophils?
### Response:
| Factors present in plasma of preeclamptic women stimulate transendothelial migration of neutrophils which is due to induction of oxidative stress and production of IL-8. |
### Instruction:
Does the thiazolidinedione ciglitazone reduce bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice?
### Response:
| Ciglitazone reduces bacterial outgrowth and local inflammation at least during the early stage of S. pneumoniae pneumonia in mice. |
### Instruction:
Does antishock effect of anisodamine involve a novel pathway for activating alpha7 nicotinic acetylcholine receptor?
### Response:
| These findings demonstrate that the antishock effect of anisodamine is intimately linked to alpha7nAChR-dependent anti-inflammatory pathway. |
### Instruction:
Does alkaline phosphatase treatment improve renal function in severe sepsis or septic shock patients?
### Response:
| In severe sepsis and septic shock, infusion of AP inhibits the upregulation of renal inducible NO synthase, leading to subsequent reduced NO metabolite production, and attenuated tubular enzymuria. This mechanism may account for the observed improvement in renal function. |
### Instruction:
Is loss of renal function associated with deterioration of health-related quality of life in kidney transplant patients?
### Response:
| Our data demonstrated that among KTP deterioration of renal function was associated with a worse HRQOL. |
### Instruction:
Is understanding of anesthesia machine function enhanced with a transparent reality simulation?
### Response:
| Schematic simulations that transparently allow learners to visualize, and explore, underlying system dynamics and relations among components may provide a more effective mental model for certain systems. This may lead to a deeper understanding of how the system works, and therefore, we believe, how to detect and respond to potentially adverse situations. |
### Instruction:
Do medical students learn over distance using virtual reality simulation?
### Response:
| These findings suggest the feasibility and acceptability by students in the use of VR simulation integrated into a PBL learning session, as well as multipoint distance technologies that allowed interaction between students and tutors in different locations. The authors believe that these modalities can be applied where students and tutors from different institutions are in separate locations and can be used to support interactive experiential learning in a distributed network or on site and suggest areas for additional research. |
### Instruction:
Is neonatal high pressure hydrocephalus associated with elevation of pro-inflammatory cytokines IL-18 and IFNgamma in cerebrospinal fluid?
### Response:
| Independent of the pathogenesis, neonatal HPHC is associated with the activation of the pro-inflammatory cytokines (IL-18 and IFNgamma) in the CSF, whereas CSF apoptosis biomarkers (sFasL) were unchanged. This suggests that anti-inflammatory treatment (in addition to shunting) could be helpful to preserve cerebral white matter. |
### Instruction:
Does laparoscopic improve perioperative outcomes of antireflux surgery at US academic centers?
### Response:
| In the context of US academic centers, approximately three quarters of antireflux procedures are being performed using the laparoscopic approach. These data suggest that laparoscopy has improved in-hospital outcomes when compared with open surgery and is preferred for the surgical treatment of GERD. |
### Instruction:
Do hemangioblasts from human embryonic stem cells generate multilayered blood vessels with functional smooth muscle cells?
### Response:
| These results demonstrate that hemangioblasts (BCs) generated from hESCs are tripotential and can provide a potentially inexhaustible source of cells for the treatment of human blood and vascular diseases. |
### Instruction:
Do foetal 'flat ' bile acids reappear during human liver regeneration after surgery?
### Response:
| Urinary BA output increases and flat-BAs reappear in urine during human liver regeneration. These results suggest that determination of BAs in urine may be an interesting parameter obtained by non-invasive techniques whose actual clinical value during human liver regeneration warrants further evaluation. |
### Instruction:
Does fluid shear attenuate endothelial pseudopodia formation into the capillary lumen?
### Response:
| The results suggest that there is a mechanism that serves to control cytoplasmic projections in capillary endothelium that is under the control of hemodynamic fluid stress. Investigation of pseudopodia growth on endothelial cells may be significant in understanding capillary obstruction in cardiovascular diseases. |
### Instruction:
Is area-level poverty associated with greater risk of ambulatory-care-sensitive hospitalizations in older breast cancer survivors?
### Response:
| Elderly breast cancer survivors who lived in high-poverty census tracts may be at increased risk of reduced posttreatment follow-up care, preventive care, or symptom management as a result of not having adequate, timely, and high-quality ambulatory primary care as suggested by ACSH. |
### Instruction:
Is wSSV ie1 promoter more efficient than CMV promoter to express H5 hemagglutinin from influenza virus in baculovirus as a chicken vaccine?
### Response:
| The production of H5 HA by baculovirus was enhanced with WSSV ie1 promoter, especially compared with CMV promoter. This contributed to effective elicitation of HA-specific antibody in vaccinated chickens. This study provides an alternative choice for baculovirus based vaccine production. |
### Instruction:
Is the metabolic syndrome amplified in hypothyroid rheumatoid arthritis patients : a cross-sectional study?
### Response:
| Hypothyroid RA patients, particularly female patients, have a more unfavourable cardiovascular risk profile, reflected by an increased prevalence of the MetS and higher Framingham score, than euthyroid RA patients, suggesting a greater need for cardiovascular risk management in these patients to prevent future CVD events. |
### Instruction:
Are folliculin mutations associated with severe COPD?
### Response:
| Genetic variation in folliculin does not appear to be a major risk factor for severe COPD. These data suggest that familial spontaneous pneumothorax and COPD have distinct genetic causes, despite some overlap in radiographic characteristics. |
### Instruction:
Does chronic lipoic acid treatment worsen energy imbalances in streptozotocin-induced diabetic rats?
### Response:
| Our results indicate that chronic treatment with LA aggravates energy imbalances in diabetic animals. Moreover, our data suggest the need to reconsider the use of LA as an adjuvant in the prevention and treatment of type 1 diabetes. |
### Instruction:
Is gastric surgery a risk factor for the development or progression of Barrett 's epithelium?
### Response:
| This lack of association between gastric surgery and Barrett's epithelium suggests that pancreatic-biliary reflux with limited acid is not sufficient for the genesis of Barrett's epithelium. |
### Instruction:
Does [ Replacement of androgen receptor gene cause complete androgen insensitivity in a large family ]?
### Response:
| Mutation Arg773His in the AR gene leads to CAIS in this family. Molecular genetic testing of CAIS facilitates not only prenatal genetic diagnosis but also preimplantation genetic diagnosis and offers genetic counseling for future pregnancies to abandon the transmission of the mutated X chromosome to the coming generation. |
### Instruction:
Does [ Adenovirus-mediated VEGF165 gene transfer have neuroprotective effects in neonatal rats following hypoxic-ischemic brain damage ]?
### Response:
| Ad-VEGF gene transfer can increase the expression of VEGF mRNA and VEGF protein, decrease neuronal apoptosis, and increase angiopoiesis in the brain. This attenuates brain damage and improves long-term learning and memory functions in neonatal rats after HIBD. |
### Instruction:
Do daily exercise fluctuations and dietary patterns during training predict visceral fat regain in obese women?
### Response:
| Our results revealed that daily exercise fluctuations and dietary patterns were useful predictors of visceral fat regain. |
### Instruction:
Are [ Hypoxia/reoxygenation-induced increased activity and expression of PTP-1B in neonatal rat cardiomyocytes mediated by nitric oxide ]?
### Response:
| This study showed that pretreatment with L-NAME, a non-selective inhibitor of NOS, prevented the hypoxia/reoxygenation-induced increase in PTP-1B activity and expression in cardiomyocytes, suggesting PTP-1B activation during hypoxia/reoxygenation was mediated by nitric oxide. |
### Instruction:
Does ultrasonic cardiac output monitor provide accurate measurement of cardiac output in recipients after liver transplantation?
### Response:
| This is the first study to evaluate the accuracy of USCOM in the post-liver transplant setting. This device is accurate in measuring CO in liver transplant recipients postoperatively. Possible risks of arrhythmia, infection and pulmonary artery rupture can be avoided because of its noninvasive nature. USCOM should be considered as an alternative in hemodynamic monitoring after liver transplantation. |
### Instruction:
Does propofol infusion shorten and attenuates oxidative stress during one lung ventilation?
### Response:
| Propofol infusion, compared with isoflurane inhalation, attenuates ROS production and limits it for 20 minutes after resuming 2LV from OLV. Propofol infusion may be beneficial to patients with inadequate antioxidant capacity. |
### Instruction:
Does [ Erythropoietin suppress the expressions of TGF-beta1 and collagen in rat cardiac fibroblasts induced by angiotensin II ]?
### Response:
| EPO suppresses the upregulated expressions of TGF-beta1 and increased production of collagen induced by Ang II through activating the PI3-K/Akt signaling pathway in neonatal rat CFs. |
### Instruction:
Does hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuate mucosal inflammation during intestinal hypoxia?
### Response:
| HIF-1alpha-dependent repression of ENT2 increases mucosal adenosine signaling and attenuates hypoxia-associated inflammation of the intestine. |
### Instruction:
Does [ Atopic dermatitis aggravate the allergic airways inflammation in acute viral bronchiolitis ]?
### Response:
| Atopic children below 2 years with AD produce more NO after AVB than non-atopic children or atopic children without any history of AVB. Maternal feeding decreases FeNO. |
### Instruction:
Are distinct determinants in HIV-1 Vif and human APOBEC3 proteins required for the suppression of diverse host anti-viral proteins?
### Response:
| Our data suggest that distinct regions of A3F and A3G are targeted by HIV-1 Vif molecules. However, HIV-1 Vif suppresses A3F, A3C, and A3DE through similar recognition determinants, which are conserved among Vif molecules from diverse HIV-1 strains. Mapping these determinants may be useful for the design of novel anti-HIV inhibitors. |
### Instruction:
Do quality of life assessment as the treatment outcome evaluation of war torture survivors according to gender?
### Response:
| Generally, the quality of life results, both men and women war torture survivors are representing the evaluation of treatment outcome, justifying fully purpose of this treatment type. |
### Instruction:
Does chronic periglandular inflammation on prostate needle biopsy increase the likelihood of cancer on subsequent biopsy?
### Response:
| Although inflammation on initial and subsequent biopsy does not predict prostate cancer in this cohort, we cannot dismiss its role in prostate cancer pathogenesis. Additional research is necessary to explore the relationship between prostate inflammation and prostate cancer development. |
### Instruction:
Does recombinant human thyrotropin enhance endothelial-mediated vasodilation of conduit arteries?
### Response:
| rhTSH causes marked and persistent activation of the endothelial mediated vasodilation, independent of systemic hemodynamic changes. |
### Instruction:
Is beta-catenin involved in N-cadherin-dependent adhesion , but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells?
### Response:
| Wnt16 does not activate canonical Wnt signaling in E2A-PBX1-positive cells. Instead, beta-catenin is involved in N-cadherin-dependent adherence junctions, suggesting for the first time that leukemia-stroma interactions may be mediated via an N-cadherin-dependent mechanism. |
### Instruction:
Is the pathogen receptor liver and lymph node sinusoidal endotelial cell C-type lectin expressed in human Kupffer cells and regulated by PU.1?
### Response:
| LSECtin is expressed by liver myeloid cells, and its expression is dependent on the PU.1 transcription factor. |
### Instruction:
Is reduced fronto-temporal connectivity associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia?
### Response:
| Our data support the disconnectivity hypothesis in schizophrenia, enlightening a link between reduced fronto-temporal connectivity and "frontal" cognitive deficits. Reduced gray matter density may be involved primarily in the pathogenesis of some of these disconnected areas. |
### Instruction:
Is weight increase associated with skeletal muscle immunostaining for advanced glycation end products , receptor for advanced glycation end products , and oxidation injury?
### Response:
| The increase of skeletal muscle AGEs/RAGE and markers of inflammation and oxidative injury in association with weight gain and old age suggest a pathogenic role of AGEs in weight gain and in sarcopenia of aging. |
### Instruction:
Are genetic polymorphisms associated with serum levels of sex hormone binding globulin in postmenopausal women?
### Response:
| Some common genetic variants of the SHBG gene, and particularly an A/G polymorphism situated in the 5' region, influence serum SHBG levels. However, a significant association with BMD or osteoporotic fractures has not been demonstrated. |
### Instruction:
Do albumin-based or albumin-linked calibrators cause a positive bias in serum proteins assayed by the biuret method?
### Response:
| Standard Reference Material 927c based on pure bovine albumin is still recommended and used as the primary standard for assays of total protein by colourimetric methods. The albumin calibrator is responsible for a positive bias of approximately 3%-5% in serum total protein assayed by the biuret reaction both in the reference and in current methods. Its substitution by a serum calibrator attested by the Kjeldahl method could solve this drawback. Clin Chem Lab Med 2009;47:91-101. |
### Instruction:
Does lysophosphatidylcholine induce endothelial cell injury by nitric oxide production through oxidative stress?
### Response:
| These findings suggest that LPC induces the overproduction of NO, which may increase the oxidative stress on endothelial cells and lead to endothelial cell injury. |
### Instruction:
Does systemic use of the endolysin Cpl-1 rescue mice with fatal pneumococcal pneumonia?
### Response:
| Cpl-1 may provide a new therapeutic option in the treatment of pneumococcal pneumonia. |
### Instruction:
Do dynamic preload indicators fail to predict fluid responsiveness in open-chest conditions?
### Response:
| Our results suggest that the dynamic preload indicators PPV and SVV are able to predict fluid responsiveness under closed-chest conditions, whereas all static and dynamic preload indicators fail to predict fluid responsiveness under open-chest conditions. |
### Instruction:
Is opposing effects of sirtuins on neuronal survival : SIRT1-mediated neuroprotection independent of its deacetylase activity?
### Response:
| Overall, our study makes three contributions - (a) it represents the first analysis of SIRT3-7 in the regulation of neuronal survival, (b) it shows that neuroprotection by SIRT1 can be mediated by a novel, non-catalytic mechanism, and (c) that subcellular localization may be an important determinant in the effect of SIRT5 on neuronal viability. |
### Instruction:
Does galactomannan serve as a surrogate endpoint for outcome of pulmonary invasive aspergillosis in neutropenic hematology patients?
### Response:
| In neutropenic patients with seropositive IA, serum galactomannan index outcome strongly correlates with survival, autopsy findings, and response outcome. This finding may have implications for patient management and for clinical trial design. |
### Instruction:
Are twenty-four-month postradiation prostate biopsies strongly predictive of 7-year disease-free survival : results from a Canadian randomized trial?
### Response:
| Two-year post-RT prostate biopsies were strongly predictive of subsequent DFS. Biopsies with severe treatment effect were considered negative. |
### Instruction:
Do [ Evaluation of efficacy and safety on steroid withdraw at the seventh day after liver transplantation ]?
### Response:
| Steroid withdrawal strategy at day 7 is same safety and efficacy as steroid withdrawal at 3 month. |
### Instruction:
Are high mean platelet volume , low-grade systemic coagulation and fibrinolytic activation associated with androgen and insulin levels in polycystic ovary syndrome?
### Response:
| PCOS patients had low-grade systemic coagulation and fibrinolytic activation as evidenced by elevated D-dimer, and increased WBC and MPV levels suggesting that hematological parameters could potentially be used as indicators of risk factor for atherosclerosis in PCOS women. |
### Instruction:
Are overweight and obesity in old age associated with greater dementia risk?
### Response:
| Older persons with higher BMI scores have less dementia risk than their counterparts with lower BMI scores. High BMI scores in late life should not necessarily be considered to be a risk factor for dementia. |
### Instruction:
Do neutrophils of centenarians show function levels similar to those of young adults?
### Response:
| Progressive impairment of the immune system accompanies aging. The better preservation of function and antioxidant systems in the neutrophils of centenarians could play a key role in the longevity of these subjects. |
### Instruction:
Is arm use after left or right hemiparesis influenced by hand preference?
### Response:
| These findings emphasize the influence of hand preference on arm use after stroke for the ipsilesional but not the contralesional arm. Although both stroke groups used their ipsilesional more than their contralesional arm, the difference was greater for the right hemisphere damage group who used their ipsilesional arm 4 times more frequently than their contralesional arm, whereas the left hemisphere damage group used their ipsilesional arm 2 times more frequently than their contralesional arm. |
### Instruction:
Does microarray RNA expression analysis of cerebral white matter lesions reveal changes in multiple functional pathways?
### Response:
| WML represent areas with a complex molecular phenotype. From this and previous evidence, WML may arise through tissue ischemia but may also reflect the contribution of additional factors like blood-brain barrier dysfunction. Differential expression of genes in WM[L] compared to WM[C] indicate a "field effect" in the seemingly normal surrounding white matter. |
### Instruction:
Do adult protective services use for older adults at the time of hospital discharge?
### Response:
| The APS system does not augment, nor does it replace, adequate hospital discharge planning. The use of the APS system as a safety net at the time of hospital discharge is a symptom of a grave problem that will only worsen as the number of elderly adults increases and adds stress to an already overburdened healthcare system. |
### Instruction:
Is nonmyocardial production of ST2 protein in human hypertrophy and failure related to diastolic load?
### Response:
| In human hypertrophy and failure, serum ST2 correlates with the diastolic load. Though the heart, endothelium, and leukocytes express components of ST2/ST2L/IL-33 pathway, the source of circulating serum ST2 is extra-myocardial. |
### Instruction:
Is [ Islet isolation outcome influenced by pancreas preparation method ]?
### Response:
| Pancreas preparation method is one of which influences on islet isolation outcome. |
### Instruction:
Does serum alpha-fetoprotein level per tumor volume reflect prognosis in patients with hepatocellular carcinoma after curative hepatectomy?
### Response:
| AFP/volume represents a better prognostic indicator for patients with HCC than serum AFP value alone. In particular, patients with AFP/volume > 20.0 are likely to experience recurrence within 6 months after curative hepatectomy. |
### Instruction:
Does a new PET scanner with semiconductor detectors enable better identification of intratumoral inhomogeneity?
### Response:
| These phantom and clinical studies suggested that this new PET scanner has the potential for better identification of intratumoral inhomogeneity, probably because of its high spatial resolution and low scatter noise. |
### Instruction:
Does partial bladder outlet obstruction reduce the tissue antioxidant capacity and muscle nerve density of the guinea pig bladder?
### Response:
| This study demonstrates that the antioxidant status of guinea pig bladders exposed to outlet obstruction decreased which might be associated with the observed reduction in nerve density. The results strengthen the hypothesis that oxidative stress is involved in the pathophysiology of bladder dysfunction related to obstructed bladders. Neurourol. Urodynam. 28:461-467, 2009. (c) 2008 Wiley-Liss, Inc. |
### Instruction:
Does whole genome-expression profiling reveal a role for immune and inflammatory response in abdominal aortic aneurysm rupture?
### Response:
| The differential expression of genes involved in immune and inflammatory responses was confirmed at AAA rupture site. These genes may represent novel targets for treatment of aneurysms. |
### Instruction:
Does increased insulin sensitivity by metformin enhance intense-pulsed-light-assisted hair removal in patients with polycystic ovary syndrome?
### Response:
| Adding metformin to IPL in women with PCOS results in a significant improvement in insulin sensitivity and hirsutism. |
### Instruction:
Does gene expression meta-analysis identify metastatic pathways and transcription factors in breast cancer?
### Response:
| By pathway meta-analysis many biological mechanisms beyond major characteristics such as proliferation are identified. Transcription factor analysis identifies a number of key factors that support central pathways. Several previously proposed treatment targets are identified and several new pathways that may constitute new targets are identified. |
### Instruction:
Does reduced calmodulin expression accelerate transient outward potassium current inactivation in diabetic rat heart?
### Response:
| Diabetes-induced acceleration of I(to) current inactivation is due to a reduced effect of CaMKII on I(to) channels as a result of a diabetes-induced reduction in calmodulin protein expression. A correct follow up of the insulin treatment could prevent this alteration. |
### Instruction:
Do macrophage-secreted factors enhance the in vitro expansion of DMD muscle precursor cells while preserving their myogenic potential?
### Response:
| Using macrophagic factors, we were able to increase the amount of DMD-mpcs obtainable after 38 days of culture by >7 x 10(3)-fold. These findings indicate that macrophagic factors hold great potential for future use in cell transplantation protocol. |
### Instruction:
Is early post-ischemic hyperemia on transcranial cerebral oxygen saturation monitoring in carotid endarterectomy associated with severity of cerebral ischemic insult during carotid artery clamping?
### Response:
| Early post-ischemic hyperemia in CEA is correlated with the severity of cerebral ischemic insult during clamping of the ICA. |
### Instruction:
Is television news exposure related to fear of breast cancer?
### Response:
| These results suggest a relationship between exposure to breast cancer coverage in television news programs and fear of breast cancer. |
### Instruction:
Is velocity propagation of early diastole a valuable tool for left ventricular remodelling after the first myocardial infarction?
### Response:
| In this study, Vp was the only valuable Doppler echocardiographic tool that reflected early LVR and LLVR. |
### Instruction:
Is after an episode of acute low back pain , recurrence unpredictable and not as common as previously thought?
### Response:
| This study challenges the assumption that the majority of subjects will have a recurrence of LBP in a 1-year period. After the resolution of an episode of acute LBP, about 25% of subjects will have a recurrence in the next year. It is difficult to predict who will have a recurrence within the next year. |
### Instruction:
Is prevalence of Foxp3 positive T regulatory cells increased during progression of cutaneous squamous tumors?
### Response:
| Tregs is related to cutaneous squamous tumor progression. |
### Instruction:
Do molecular phylogenetics reveal multiple tertiary vicariance origins of the African rain forest trees?
### Response:
| Molecular phylogenetic dating analyses of this large pan-African clade of Annonaceae unravels an interesting pattern of diversification for rain forest restricted trees co-occurring in West/Central and East African rain forests. Our results suggest that repeated reconnections between the West/Central and East African rain forest blocks allowed for biotic exchange while the break-ups induced speciation via vicariance, enhancing the levels of endemicity. These results provide an explanation for present day distribution patterns and origins of endemicity for African rain forest trees. Moreover, given the pre-Pleistocene origins of all the studied endemic East African genera and species, these results also offer important insights for setting conservation priorities in these highly diversified but threatened ecosystems. |
### Instruction:
Is cD56 expression in T-cell acute lymphoblastic leukemia associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy?
### Response:
| CD56 is expressed on a subset of adult T-ALL with distinct immunophenotypical features and higher resistance to therapy. Most CD56(+) ALL were treated in the high-risk arm of the GMALL study protocols owing to their non-thymic phenotype. Thus after risk adapted treatment a prognostic impact of CD56 expression was not detectable. |
### Instruction:
Do echo Doppler parameters predict response to cardiac resynchronization therapy?
### Response:
| The QED and IVMD predict reverse remodelling and survival following CRT. These parameters are easy to obtain, provide valuable prognostic information, and should thus be measured in CRT candidates evaluated by echocardiography. |
### Instruction:
Does porphyrin homeostasis maintained by ABCG2 regulate self-renewal of embryonic stem cells?
### Response:
| The present work demonstrated that ABCG2 protects ES cells from PPIX accumulation during colony expansion, and that p53 and gammaH2AX acts as a downstream checkpoint of ABCG2-dependent defense machinery in order to maintain the self-renewal of ES cells. |
### Instruction:
Does butyrate modulate oxidative stress in the colonic mucosa of healthy humans?
### Response:
| This study demonstrated that butyrate is able to beneficially affect oxidative stress in the healthy human colon. |
### Instruction:
Does capsaicin block HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine pulmonary arteries?
### Response:
| Capsaicin effectively inhibits the detrimental effects of HIV protease inhibitor ritonavir on vasomotor functions of porcine pulmonary arteries. These findings may suggest that capsaicin could have clinical applications to prevent vascular and pulmonary complications of HAART drugs in HIV patients. |
### Instruction:
Does early insulin secretion failure lead to diabetes in Chinese subjects with impaired glucose regulation?
### Response:
| Failure of beta-cell function might be the main reason for both IGT and IFG developing into diabetes instead of aggravated insulin resistance. |
### Instruction:
Does human papillomavirus found in sperm head of young adult males affect the progressive motility?
### Response:
| This is the first report estimating the percentage of HPV-positive sperm in infected subjects and the association between HPV infection and sperm motility. |
### Instruction:
Is aggression related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects?
### Response:
| The present study provides first-time evidence for a specific interrelation between the 5-HT(1A) receptor distribution, sex hormones, and aggression in humans. Our findings point to a reduced down-stream control due to higher amounts or activities of frontal 5-HT(1A) receptors in more aggressive subjects, which is presumably modulated by sex hormones. |
### Instruction:
Is [ Acute scrotum a condition requiring surgical intervention ]?
### Response:
| Testicular torsion and tumor are the units in which the surgical exploration is performed without discussion. Beside that, torsion of the testicular or epididymic appendix is the most frequent occurring diagnosis. There is a group of surgeons, who performed in this unit conservative management. |
### Instruction:
Does successful AV fistula creation lead to higher catheter use : the experience by the Northwest Renal Network 16 Vascular Access Quality Improvement Program . Four years follow-up?
### Response:
| The success of Network 16's AVF interventions demonstrates the effectiveness of Network education promoting multidisciplinary teamwork, and innovative strategies to increase dramatically AVF use without substantial increase in catheter use. |
### Instruction:
Do phenotypes of the ovarian follicular basal lamina predict developmental competence of oocytes?
### Response:
| These findings provide direct evidence that the phenotype of the follicular basal lamina is related to oocyte competence. |
### Instruction:
Is endometrial fluid a specific and non-invasive biological sample for protein biomarker identification in endometriosis?
### Response:
| Endometrial fluid represents a novel sample for proteomic analysis offering reliable, disease specific information on protein expression, facilitating the discovery of biomarkers for endometriosis. The results described here complement previous proteomic studies, providing new endometriosis-related proteins to be validated as diagnostic markers. |
### Instruction:
Does rate of inpatient weight restoration predict outcome in anorexia nervosa?
### Response:
| Weight gain rate during inpatient treatment for AN was a significant predictor of short-term clinical outcome after discharge. It is unclear whether weight gain rate exerts a causal effect or is rather a marker for readiness to tolerate weight restoration and engage in the recovery process. |
### Instruction:
Is wound healing impaired in rats undergoing perioperative treatment with the antineoplastic agent taurolidine?
### Response:
| Our results suggest that wound healing does not seem to be impaired by TRD in rats. |
### Instruction:
Is the Finnish Diabetes Risk Score associated with insulin resistance and progression towards type 2 diabetes?
### Response:
| The results indicate that the FINDRISC can be applied to detect insulin resistance in a population at high risk for type 2 diabetes and predict future impairment of glucose tolerance. |
### Instruction:
Does hepatocyte-specific deletion of Cdc42 result in delayed liver regeneration after partial hepatectomy in mice?
### Response:
| Our results revealed important roles of Cdc42 in the regulation of proliferative signaling during liver regeneration. |
### Instruction:
Does the economics of new faculty hire in basic science?
### Response:
| Investments in basic science research, even when successful, may require significant financial subsidies from academic health centers. |
### Instruction:
Does islet transplantation with alemtuzumab induction and calcineurin-free maintenance immunosuppression result in improved short- and long-term outcomes?
### Response:
| Islet transplantation with alemtuzumab induction was well tolerated and resulted in improved short- and long-term outcomes. Further investigation is underway for validation. |
### Instruction:
Does glucose infusion suppress surgery-induced muscle protein breakdown by inhibiting ubiquitin-proteasome pathway in rats?
### Response:
| The present study indicates that glucose infusion, even at a relatively low rate, suppresses muscle protein breakdown in the early postoperative period. The mechanism of this effect is related to the suppression of the ubiquitin-proteasome pathway, accompanied by activation of insulin signaling. |
### Instruction:
Is preoperative use of statins associated with reduced early delirium rates after cardiac surgery?
### Response:
| Preoperative administration of statins is associated with the reduced risk of postoperative delirium after cardiac surgery with cardiopulmonary bypass. |
### Instruction:
Is positive adnexal or uterine serosal involvement in stage IIIC endometrial cancer an adverse factor for recurrence?
### Response:
| Patients with stage IIIC endometrial cancer and metastasis to adnexae and/or serosa have a higher risk of recurrence than those with node metastasis alone. Optimal adjuvant therapy for these groups remains unclear. |
### Instruction:
Does perinatal alcohol exposure in rat induce long-term depression of respiration after episodic hypoxia?
### Response:
| Respiratory facilitation after repeated hypoxia was converted to long-term depression in rats treated with alcohol in utero. Alcohol exposure during pregnancy may therefore induce long-term maladaptive behavior of the respiratory system in neonates. |
### Instruction:
Does mobility and fall in people with Huntington 's disease?
### Response:
| A high proportion of HD patients have recurrent falls, and the BBS and TUG appear to be useful in falls risk assessment. |
### Instruction:
Does microvessel density correlate with lymph node metastases and prognosis in hilar cholangiocarcinoma?
### Response:
| Neovascularization is associated with nodal spread as well as local recurrence and serves as an independent prognostic factor for survival after curative resection of hilar cholangiocarcinoma. Therefore, tumor-associated neovascularization seems to be critically involved in the progression of this tumor entity. In addition, neovascularization may represent a potential target in he development of new therapeutic approaches in hilar cholangiocarcinoma. |
### Instruction:
Do sFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway?
### Response:
| Taken together, these data strongly suggest that epigenetic silencing of SFRP genes leads to oncogenic activation of the Wnt pathway and contributes to cervical cancer progression through the EMT program. |
### Instruction:
Do computer-based simulation of the Bielschowsky head-tilt test using the SEE++ software system?
### Response:
| Comparisons of simulation results with patient-measured data showed a good correlation between the simulated and the measured data. Further comparisons with patient data are planned. |
### Instruction:
Does [ Prophylactic administration of Yunnan Baiyao capsule reduce intra-operative blood loss in orthognathic surgery ]?
### Response:
| Prophylactic oral administration of Yunnan Baiyao capsules can effectively reduce the intra-operative blood loss in bimaxillary orthognathic surgery. Yunnan Baiyao capsule are an effective and safe haemostatic traditional Chinese medicine. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.