question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Is hBsAg loss in patients treated with peginterferon alfa-2a and adefovir associated with SLC16A9 gene variation and lower plasma carnitine levels?
### Response:
| In chronic hepatitis B patients treated with peginterferon and adefovir, we identified strong associations of SLC16A9 gene variation and carnitine levels with HBsAg loss. Our results further suggest that a lower baseline plasma carnitine level increases the proliferative capacity of CD8 T cells, making patients more su... |
### Instruction:
Is preoperative pulmonary function strongly related to myasthenic crisis after thymectomy?
### Response:
| MCAT may occur in patients with T-MG after thymectomy especially within 2 years after disease onset. Preoperative mFVC/pFVC is strongly associated with the occurrence of MCAT postoperatively. |
### Instruction:
Is immunoglobulin-like transcript 2 ( ILT2 ) a biomarker of therapeutic response to oncolytic immunotherapy with vaccinia viruses?
### Response:
| ILT2 is a new putative biomarker of T cell and clinical response in patients treated with oncolytic vaccinia virus immunotherapy. Further confirmation of ILT2 as a biomarker requires prospective validation in a larger series of clinical trials. |
### Instruction:
Is quality of life modestly improved in older patients with mild primary hyperparathyroidism postoperatively : results of a prospective multicenter study?
### Response:
| This study showed, in patients with mild pHPT, an improvement of QoL 1 year after parathyroidectomy. Patients <70 years and with calcemia ≥10.4 mg/dL had a more significant improvement. |
### Instruction:
Does diffuse excessive high signal intensity in low-risk preterm infants at term-equivalent age predict outcome at 1 year : a prospective study?
### Response:
| DEHSI in premature infants is neither a predictive measure for short-term adverse neurobehavioral outcome nor related to perinatal risk characteristics. Extrauterine exposure time had a differential effect on WM maturational trajectories in infants with DEHSI compared to those without. We suggest DEHSI may represent an... |
### Instruction:
Do caregiving experiences predict changes in spiritual well-being among family caregivers of cancer patients?
### Response:
| Findings point to the importance of family support in facilitating the search for meaning and peace shortly after a loved one's cancer diagnosis and suggest that interventions targeting caregivers' support system may enhance their spiritual well-being. |
### Instruction:
Are chronic diseases strongly associated with sickness absences in a sample of Italian public employees?
### Response:
| This study highlights the relevant association between chronic diseases and sickness absence in Italian public employees. Our findings indicate the importance of considering the health status when designing preventive interventions aimed at decreasing sickness absences in this population. |
### Instruction:
Does the Nrf2 transcription factor contribute to resistance to cisplatin in bladder cancer?
### Response:
| Nrf2 overexpression in bladder cancer is associated with clinically relevant cisplatin resistance that is reversible in experimental models and should now be tested in prospective studies. |
### Instruction:
Is urinary angiotensinogen elevated in patients with nephrolithiasis?
### Response:
| Urinary UA is a novel biomarker for patients with nephrolithiasis, which indicates renal tubular injury. Further study on the molecular pathogenic mechanism of UA and larger scale of clinical trial is required. |
### Instruction:
Does mannitol infusion within 15 min of cross-clamp improve living donor kidney preservation?
### Response:
| Because slow graft recovery in the first weeks after transplantation represents a risk factor for long-term graft function and survival, we believe that this change in pretreatment protocol will improve renal transplants in patients receiving LDK. |
### Instruction:
Does a dual tyrosine kinase inhibitor lapatinib suppress overexpression of matrix metallopeptidase 1 ( MMP1 ) in endometrial cancer?
### Response:
| MMP1 expression was high in tissues and sera in patients with endometrial cancer. Lapatinib inhibited MMP1 via both HER2 and EGFR signaling pathways. Both AKT and ERK need to be inhibited for efficient MMP1 suppression by lapatinib. Activating protein-1 (AP-1) binding site of MMP1 promoter is uniquely required for MMP1... |
### Instruction:
Does estrogen-mimicking isoflavone genistein prevent bone loss in a rat model of obstructive sleep apnea-hypopnea syndrome?
### Response:
| Genistein can improve the reduction in bone mass and bone strength due to OSAHS in OVX rats, which may be attributed to the increase in bone formation and inhibition of bone resorption. Our findings suggest that genistein may be used to treat and prevent osteoporosis in postmenopausal women with OSAHS. |
### Instruction:
Does amplitude-integrated electroencephalography show that doxapram influences the brain activity of preterm infants?
### Response:
| Doxapram treatment influences aEEG in preterm infants, showing higher percentages of continuous activity as well as more electrographic seizure activity and less sleep-wake cycling. It should, therefore, be used with caution in very preterm infants. |
### Instruction:
Does sociality modulate the effects of ethanol in zebra fish?
### Response:
| Our results demonstrate the feasibility of exposing a single individual to EtOH and test it together with untreated subjects. This approach has the potential to unravel the social determinants of individual response to alcohol, by enabling us to dissociate EtOH exposure from sociality. |
### Instruction:
Do cell-free DNA blood levels in colorectal cancer patients correlate with mismatch repair-proficiency?
### Response:
| Compared to MMR-proficient CRCs, MMR-deficient tumors occurred in older patients, and were more commonly proximally-located. Despite the presence of distinct biological and histopathological characteristics, both tumor types produced similar CFD blood levels. |
### Instruction:
Does critical analysis of results after chimney endovascular aortic aneurysm repair raise cause for concern?
### Response:
| These results demonstrate that chEVAR can be completed with a high degree of success; however, perioperative complications and MAEs during follow-up, including loss of chimney patency and endoleak, may occur at a higher rate than previously reported. Elective use of chEVAR should be performed with caution, and comparis... |
### Instruction:
Is time to diagnosis of Ewing tumors in children and adolescents associated with metastasis or survival : a prospective multicenter study of 436 patients?
### Response:
| TtD of Ewing tumors was long, especially for adolescents and for certain tumor sites, and did not improve over time. But TtD was not associated with metastasis, surgical outcome, or survival. These findings could be used to comfort parents at diagnosis and in expert testimony produced for malpractice claims. |
### Instruction:
Do serum hepcidin concentrations correlate with ferritin in patients with inflammatory bowel disease?
### Response:
| This retrospective analysis suggests that iron deficiency is the key trigger for hepcidin regulation in IBD patients with anemia. |
### Instruction:
Are th22 cells associated with hepatocellular carcinoma development and progression?
### Response:
| Elevation of circulating Th22 cells and IL-22 may be implicated in the pathogenesis of HCC, and potentially be cellular targets for therapeutic intervention. |
### Instruction:
Are monocyte-activation phenotypes associated with biomarkers of inflammation and coagulation in chronic HIV infection?
### Response:
| Plasma inflammatory biomarkers that predict morbidity and mortality were strongly associated with monocyte activation and migration, modestly associated with T-cell maturation, and not associated with CD8(+) T-cell activation phenotypes. These findings suggest that strategies to control monocyte activation warrant furt... |
### Instruction:
Does the fatty acid-bile acid conjugate Aramchol reduce liver fat content in patients with nonalcoholic fatty liver disease?
### Response:
| Three months' administration of the fatty acid-bile acid conjugate Aramchol is safe, tolerable, and significantly reduces liver fat content in patients with NAFLD. The reduction in liver fat content occurred in a dose-dependent manner and was associated with a trend of metabolic improvements, indicating that Aramchol m... |
### Instruction:
Do metabolic adaptation and neuroprotection differ in the retina and choroid in a piglet model of acute postnatal hypoxia?
### Response:
| We showed that the retina engages a distinct pattern of signaling and transcriptional events than observed in the choroid. Retina and choroid may reflect regional sensitivity to hypoxia. While prolonged and intense hypoxia may jeopardize retinal cell survival, choroid sets up a different pattern of response, which prom... |
### Instruction:
Are soluble urokinase plasminogen activator receptor levels elevated and associated with complications in patients with type 1 diabetes?
### Response:
| The suPAR level is higher in patients with type 1 diabetes and is associated with diabetes duration and complications independent of other risk factors. suPAR is a potential novel risk marker for the management of diabetes. |
### Instruction:
Is cardioprotective trafficking of caveolin to mitochondria Gi-protein dependent?
### Response:
| Gi proteins are involved in trafficking caveolin to mitochondria to enhance stress resistance. Agents that target Gi activation and caveolin trafficking may be viable cardioprotective agents. |
### Instruction:
Does [ Study on RNA interference silencing hMSH2 induce the reversal chemo-resistance of ovarian carcinoma cell line OC3/TAX300 ]?
### Response:
| siRNA targeting hMSH2 may reverse the chemo-resistance of ovarian carcinoma cell line OC3/TAX300 and may become a treatment or a new direction in the adjuvant therapy of ovarian cancer. |
### Instruction:
Do predicting speech intelligibility with a multiple speech subsystems approach in children with cerebral palsy?
### Response:
| Children in the SMI group had articulatory subsystem problems as indexed by acoustic measures. As in the adult literature, the articulatory subsystem makes the primary contribution to speech intelligibility variance in dysarthria, with minimal or no contribution from other systems. |
### Instruction:
Is allergic rhinitis a risk factor for traffic safety?
### Response:
| Untreated AR can impair driving ability and put patients at risk. Drug therapy reduces this impairment, and AR patients should therefore be advised to always treat their condition. |
### Instruction:
Does a shortened activated partial thromboplastin time predict the risk of catheter-associated venous thrombosis in cancer patients?
### Response:
| Cancer patients undergoing catheter placement who develop CVC-associated VTE have a shorter aPTT and aPTT ratio than those who do not develop VTE. aPTT, a simple and inexpensive test might be useful as a predictor of CVC-associated VTE risk in cancer patients. |
### Instruction:
Is bile acid flux necessary for normal liver regeneration?
### Response:
| Absent BA return to the liver after PH or CCl4 injury markedly attenuates LR, though hepatocyte proliferation still occurs, inferring that BA flux and signaling are not the sole signals governing LR. Transcriptional networks involving c-jun and AP-1 are involved in the BA-specific effects on hepatocyte proliferation. |
### Instruction:
Does systemic chemotherapy in combination with pericardial window have better outcomes in malignant pericardial effusions?
### Response:
| Systemic CT plus pericardial window is a more effective treatment option compared with systemic CT alone and systemic CT plus drainage in patients with malignant effusions. |
### Instruction:
Does preoperative tumour biopsy affect the oncologic course of patients with transplantable HCC?
### Response:
| This study supports that preoperative tumour biopsy does not negatively influence the oncologic course of HCC patients eligible for LT. Hence, there is no argument to restrict biopsy in doubtful situations. |
### Instruction:
Is continuous noninvasive hemoglobin measurement useful in patients undergoing double-jaw surgery?
### Response:
| Continuous monitoring of hemoglobin may help to determine the appropriate time to perform an invasive measurement of hemoglobin in patients who undergo double-jaw surgery. |
### Instruction:
Do herbal tea extracts inhibit Cytochrome P450 3A4 in vitro?
### Response:
| This study confirms the possible implication of herbal tea constituents in the inhibition of ciclosporin and sirolimus' CYP3A4 metabolism. Combined usage of herbal teas with drug should be closely monitored. |
### Instruction:
Is desphospho-uncarboxylated matrix Gla-protein associated with mortality risk in patients with chronic stable vascular disease?
### Response:
| In patients with overt vascular disease, circulating dp-ucMGP and dp-cMGP were independently associated with the risk of all-cause and cardiovascular mortality. Since published results are conflicting regarding the dp-cMGP, we propose only circulating dp-ucMGP as a potential biomarker for assessment of additive cardiov... |
### Instruction:
Is daily number of fractures associated with road temperature in an urban area?
### Response:
| Decreasing road temperature results in increased numbers of all fractures except hip fractures. Low temperatures is a risk factor for patients > 30 years and a protective factor for patients < 15 years. |
### Instruction:
Does impact of medicare part D plan feature on use of generic drugs?
### Response:
| Cost-sharing features and utilization management tools were significantly associated with generic use in 3 commonly used medication categories. |
### Instruction:
Do eight channel transmit array volume coil using on-coil radiofrequency current sources?
### Response:
| Independent control of current amplitude and phase on each transmitting element was demonstrated. The transmit array with on-coil RF current sources enables B1 field shimming in a simple and predictable manner. |
### Instruction:
Does topical methotrexate pretreatment enhance the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers?
### Response:
| We conclude that topical MTX-pretreatment can increase intracellular PpIX production in hamster buccal pouch precancerous lesions and significantly improves the outcomes of the precancerous lesions treated with topical ALA-PDT. |
### Instruction:
Does transcriptionally regulated cell adhesion network dictate distal tip cell directionality?
### Response:
| Transcriptional regulation by means of cbp-1 and let-607 is crucial for determining directional changes during DTC migration. These regulators coordinate a gene network that is necessary for integrin-mediated adhesion. Overall, these results suggest that directional changes in cell migration rely on the precise gene re... |
### Instruction:
Is tNFSF15 an independent predictor for the development of Crohn 's disease-related complications in Koreans?
### Response:
| In Korean patients with CD, non-risk allele homozygotes of TNFSF15 SNPs rs6478108 and rs4574921 are independent genetic predictive factors for the development of strictures/non-perianal penetrating complications and perianal fistula, respectively. |
### Instruction:
Are hepatic steatosis and PNPLA3 I148M variant associated with serum Fetuin-A independently of insulin resistance?
### Response:
| Liver fat accumulation and the I148M variant of PNPLA3 are associated with serum Fetuin-A levels independently of insulin resistance. Fetuin-A may be implicated in the pathogenesis of metabolic complications associated with NAFLD. |
### Instruction:
Does extent of flow recirculation govern expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations?
### Response:
| Flow drives variations in vascular reactivity and vascular beds. Endothelial health was preserved by arterial flow but jeopardized in regions of flow recirculation in a quasi-linear manner. Similarly, SMC exposed to flow were more thrombogenic in large recirculating regions. Health, thrombosis, and atherosclerosis biom... |
### Instruction:
Does implementing a structured Enhanced Recovery After Surgery ( ERAS ) protocol reduce length of stay after abdominal hysterectomy?
### Response:
| Introducing the ERAS protocol for abdominal hysterectomy reduced length of stay without increasing complications or readmissions. |
### Instruction:
Is mucosal healing of ileal lesions associated with long-term clinical remission after infliximab maintenance treatment in patients with Crohn 's disease?
### Response:
| Complete mucosal healing after 1-2 years was a predictive factor for long-term clinical remission up to 4 years after starting infliximab. A lack of complete mucosal healing was a predictive factor for major abdominal surgery for strictures. The present study suggests that endoscopic evaluation of ileal lesions is usef... |
### Instruction:
Does inhibition of mitogen-activated protein kinase phosphatase-1 ( MKP-1 ) increase experimental stroke injury?
### Response:
| We have demonstrated that MKP-1 signaling is an endogenous protective mechanism in stroke. Our data imply that MKP-1 possesses anti-apoptotic and anti-inflammatory properties by simultaneously controlling the activities of JNK and microglial p38. |
### Instruction:
Does stretch-activation of angiotensin II type 1a receptors contribute to the myogenic response of mouse mesenteric and renal arteries?
### Response:
| Our results provide definitive evidence that myogenic responses of mouse mesenteric and renal arteries rely on ligand-independent, mechanoactivation of AT1R subtype a. The AT1R subtype a signal relies on an ion channel distinct from TRPC6 or KCNQ3, 4, or 5 to enact vascular smooth muscle cell activation and elevated va... |
### Instruction:
Does ezrin promote invasion and migration of the MG63 osteosarcoma cell?
### Response:
| Collectively, these results suggest that ezrin as a direct target of miR-183 promotes the aggressiveness of OS via increased N-cadherin and activating ERK signaling. |
### Instruction:
Are circulating plasma levels of cathepsin S and L associated with disease severity in patients with rheumatoid arthritis?
### Response:
| Although circulating levels of cathepsin S and L were significantly increased in patients with recently diagnosed RA, our data do not support the notion that circulating levels of cathepsins are relevant biomarkers for disease severity. |
### Instruction:
Does brain natriuretic hormone predict stress-induced alterations in diastolic function?
### Response:
| pro-BNP predicts both resting and stress DF, suggesting that lower BNP during MS may be a marker of diastolic dysfunction in apparently healthy individuals. |
### Instruction:
Is serum peroxiredoxin3 a useful biomarker for early diagnosis and assessemnt of prognosis of hepatocellular carcinoma in Chinese patients?
### Response:
| Serum PRDX3 can be used as a noninvasive biomarker for the diagnosis and/or prognosis of HCC. |
### Instruction:
Is elevated plasma homocysteine level associated with ischemic stroke in Chinese hypertensive patients?
### Response:
| Plasma homocysteine level is positively associated with the presence of IS, but not CHD, in Chinese hypertensive patients. |
### Instruction:
Does mouse model of posttraumatic abdominal sepsis : survival advantage of females over males depend on the cecum size?
### Response:
| Standardization by AP-L did not eliminate the gender-specific difference in mortality due to posttraumatic sepsis. The greater cecum length/filling in middle-aged male mice was not responsible for their inferior survival compared to females. |
### Instruction:
Does combination therapy of cilostazol and bepridil suppress recurrent ventricular fibrillation related to J-wave syndromes?
### Response:
| These data suggest that combination therapy of cilostazol and bepridil may be effective and safe in suppressing VF recurrence in some cases of J-wave syndromes. |
### Instruction:
Does clinico-pathological analysis of renal cell carcinoma demonstrate decreasing tumour grade over a 17-year period?
### Response:
| There was a rising incidence in the number of nephrectomies over the study period. Despite previous reports, a stage migration was not evident; however, a grade reduction was apparent in this Irish surgical series. We can demonstrate that tumour stage, nuclear grade and histological subtype are significant prognosticat... |
### Instruction:
Is spine surgeon specialty a risk factor for 30-day complication rates in single-level lumbar fusion : a propensity score-matched study of 2528 patients?
### Response:
| Our analysis demonstrates that spine surgeon specialty is not a risk factor for any of the reported 30-day complications in patients undergoing single-level lumbar fusion. These data support the currently dichotomous paradigm of training for spine surgeons. Further research is warranted to validate this relationship in... |
### Instruction:
Does tRPM8 have a key role in experimental colitis-induced visceral hyperalgesia in mice?
### Response:
| Increased expression of TRPM8 may contribute to the visceral hyperalgesia of experimental colitis. |
### Instruction:
Do rs10505474 and rs7837328 at 8q24 cumulatively confer risk of prostate cancer in Northern Han Chinese?
### Response:
| rs10505474 (A) and rs7387328 (A) at 8q24 are associated with PCa and cumulatively confer risk, suggesting the two variations could determine susceptibility to PCa in the Northern Chinese Han population. |
### Instruction:
Does implicit memory influence on metamemory during verbal learning after traumatic brain injury?
### Response:
| The results suggest that JOLs may be influenced by subliminal implicit memory. Clinical implications include the possible use of antipriming to reduce overconfidence after brain injury and delaying JOLs to improve recall. |
### Instruction:
Are inadequate corticosterone levels relative to arthritic inflammation accompanied by altered mitochondria/cholesterol breakdown in adrenal cortex : a steroid-inhibiting role of IL-1β in rats?
### Response:
| This study on inadequate adrenal glucocorticoid secretion in arthritis demonstrated altered mitochondria and altered lipid breakdown paralleled by low corticosterone levels in relation to inflammation. IL-1β is a key cytokine. |
### Instruction:
Is low body mass index associated with adverse oncological outcomes following radical prostatectomy in Korean prostate cancer patients?
### Response:
| Obese and overweight Korean PCa patients have lower Gleason scores and a reduced risk of BCR compared with normal weight patients. These findings suggest that body fat influences pathological features and oncologic outcomes of PCa. |
### Instruction:
Do plasmids encoding protein aggregation domains act as molecular adjuvants for DNA vaccines?
### Response:
| Plasmids encoding aggregation-promoting domains induce formation of insoluble intracellular aggregates that trigger caspase activation and apoptotic cell death leading to activation of the innate immune system thereby acting as genetic adjuvants. |
### Instruction:
Do three children with autism spectrum disorder learn to perform a three-step communication sequence using an iPad®-based speech-generating device?
### Response:
| With systematic instruction, children with ASD and severe communication impairment can learn to use an iPad-based SGD to complete multi-step communication sequences that involve requesting and social communication functions. |
### Instruction:
Is rapid gastric and intestinal transit a major determinant of changes in blood glucose , intestinal hormones , glucose absorption and postprandial symptoms after gastric bypass?
### Response:
| After RYGB, reducing intestinal glucose delivery to 4 kcal/min is associated with higher blood glucose, greater glucose absorption, lower incretin responses, and less GI symptoms, supporting rapid transit contribution to the exaggerated incretin responses and "dumping symptoms". |
### Instruction:
Are retinal microglia activated by systemic fungal infection?
### Response:
| As an excessive or prolonged microglial activation may lead to chronic inflammation with severe pathological side effects, causing or worsening the course of retinal dystrophies, a systemic infection may represent a risk factor to be considered in patients with ocular neurodegenerative diseases, such as diabetic retino... |
### Instruction:
Are sustained high plasma plasminogen activator inhibitor-1 levels associated with severity and mortality in septic patients?
### Response:
| The most interesting findings of our study, to our knowledge the largest series reporting PAI-1 levels during follow-up in septic patients, were that plasma PAI-1 levels during the first week were associated with inflammation, severity and mortality. |
### Instruction:
Does simvastatin reduce leucocyte- and platelet-endothelial cell interaction in murine antigen-induced arthritis in vivo?
### Response:
| Treatment of AiA mice with simvastatin showed significant reductions in platelet- and leucocyte-endothelial cell interactions, in FCD, and in the swelling of the knee joint. These results support the hypothesis of the anti-inflammatory effects of statins in the treatment of RA. |
### Instruction:
Does argonaute-2 promote miR-18a entry in human brain endothelial cells?
### Response:
| Ago-2 facilitates miR-18a entry into brain endothelial cells in vitro and in vivo. This study highlights the clinical potential of Ago-2 as a miRNA delivery platform for the treatment of brain vascular diseases. |
### Instruction:
Is haptoglobin 2-2 genotype associated with cardiovascular risk in subjects with elevated glycohemoglobin-results from the Bruneck Study?
### Response:
| Subjects with the Hp 2-2 genotype and elevated HbA1c compared with subjects with other Hp genotypes and elevated HbA1c did not show increased CVD risk. |
### Instruction:
Does a novel breast cancer-associated BRIP1 ( FANCJ/BACH1 ) germ-line mutation impair protein stability and function?
### Response:
| These results, by showing that the newly identified BRIP1 c.2992-2995delAAGA mutation is associated with instability and functional impairment of the encoded protein, provide further evidence of a breast cancer-related role for BRIP1. |
### Instruction:
Does lenalidomide enhance natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells?
### Response:
| These findings suggest that lenalidomide has the potential to enhance the rituximab-induced killing of NHL cell lines and primary B-cell chronic lymphocytic leukemia cells via a NK cell-mediated and monocyte-mediated ADCC mechanism in vitro, providing a strong rationale for the combination of lenalidomide with IgG1 ant... |
### Instruction:
Does circumferential pulmonary vein isolation with the cryoballoon technique result from a prospective 3-center study?
### Response:
| Pulmonary vein isolation with a new cryoballoon technique is feasible. Sinus rhythm can be maintained in the majority of patients with PAF by circumferential PVI using a cryoballoon ablation system. Cryoablation was less effective in patients with persistent AF than in patients with PAF. |
### Instruction:
Does blockade of angio-associated migratory cell protein inhibit smooth muscle cell migration and neointima formation in accelerated atherosclerosis?
### Response:
| These data reveal an important functional role of AAMP in the migration of SMCs, identifying AAMP as a potential target to limit lesion formation after injury. |
### Instruction:
Is exaggerated blood pressure response to exercise associated with augmented rise of angiotensin II during exercise?
### Response:
| An exaggerated BP response to exercise was associated with augmented rise of Ang II during exercise. |
### Instruction:
Does psychomotor performance measured in a virtual environment correlate with technical skills in the operating room?
### Response:
| The current study demonstrated significant correlations between operative performance in the operating room (assessed using a well-validated rating scale) and psychomotor performance in virtual environment assessed by a computer simulator. This provides strong evidence for the validity of the simulator system as an obj... |
### Instruction:
Is preoperative GATA3 mRNA expression in peripheral blood mononuclear cells up-regulated in patients with postoperative infection following hepatobiliary pancreatic surgery?
### Response:
| These results suggest that in patients with postoperative infection, Th1/Th2 balance shifts toward Th2 dominance preoperatively. |
### Instruction:
Does vascular endothelial growth factor improve myocardial functional recovery following ischemia/reperfusion injury?
### Response:
| This is the first demonstration that exogenous VEGF administration acutely improves myocardial functional recovery after ischemia. These findings may help elucidate the role of VEGF in acute stem-cell-mediated paracrine effects and suggests that isolated VEGF may be of therapeutic value. |
### Instruction:
Does exposure to nuclear antigens contribute to the induction of humoral autoimmunity during tumour necrosis factor alpha blockade?
### Response:
| Infliximab and etanercept have a differential effect on both type I interferon activity and nucleosome levels. Only elevated serum nucleosomes relate to the induction of antinucleosome antibodies after infliximab treatment. |
### Instruction:
Does genome screen of 15 Australian bipolar affective disorder pedigrees support previously identified loci for bipolar susceptibility genes?
### Response:
| Although not providing statistically significant evidence for linkage in this study, these 15 families provide support for previously identified bipolar susceptibility loci, and may aid in localizing susceptibility genes for BP in a larger combined cohort framework. |
### Instruction:
Does image preprocessing improve Fourier-based texture analysis of nuclear chromatin?
### Response:
| Smoothing of borders in segmented images can improve the analysis of Fourier-derived variables of the chromatin texture. |
### Instruction:
Does taller stature after postnatal rapid weight gain in early infancy predict overweight status at age 3?
### Response:
| Taller stature following postnatal rapid weight gain in early infancy predicts overweight status at age 3; additionally, rapid infancy weight gain contributes to the acceleration of statural growth in overweight children. |
### Instruction:
Does tumor expression of S100A6 correlate with survival of patients with stage I non-small-cell lung cancer?
### Response:
| In this study we have validated on clinical material our previous findings on cell lines in terms of S100A6 expression and post-translational modifications pattern in NSCLC. Moreover, the survival results obtained in p53-negative stage I NSCLC cases support the proposed pro-apoptotic function of S100A6 and suggest the ... |
### Instruction:
Does activation of NF-E2-related factor-2 reverse biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease?
### Response:
| We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role. |
### Instruction:
Are effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat changed?
### Response:
| Taurine enhances contractions in IR aortic rings but relaxes the contractions in normal rat aortic ring; the enhancement is endothelium-dependent and the relaxation is endothelium-independent. TEA-sensitive K(+) channel may be involved in these actions; BK(Ca) channel dysfunction and endothelium-derived substances may ... |
### Instruction:
Is fetal size in the second trimester associated with the duration of pregnancy , small fetuses having longer pregnancies?
### Response:
| Fetal size in the second trimester is a determinant of birth weight and pregnancy duration, small fetuses having lower birth weights and longer pregnancies (up to 13 days compared with large fetuses). Our results support a concept of individually assigned pregnancy duration according to growth rates rather than imposin... |
### Instruction:
Is snoN overexpression predictive of poor survival in patients with esophageal squamous cell carcinoma?
### Response:
| SnoN is likely to be the target of the amplification at 3q26 in ESCC and plays an important role in the development of ESCC, influencing disease-specific survival. |
### Instruction:
Does hepatocyte growth factor suppress production of reactive oxygen species and release of eosinophil-derived neurotoxin from human eosinophils?
### Response:
| Taken together, these data suggest that in asthma, HGF attenuates allergic airway inflammation and AHR through at least the suppression of ROS production and EDN release from eosinophils. |
### Instruction:
Is aRG1 a novel bronchodilator response gene : screening and replication in four asthma cohorts?
### Response:
| These findings identify ARG1 as a novel gene for acute BDR in both children and adults with asthma. |
### Instruction:
Does bone marrow stromal cell therapy improve femoral bone mineral density and mechanical strength in ovariectomized rats?
### Response:
| The present study suggests that bone strength may be improved by direct BMSC injection. |
### Instruction:
Is self-reported diabetes associated with self-management behaviour : a cohort study?
### Response:
| Many people with physician-diagnosed diabetes do not report having the disease, but most demographic and clinical features do not distinguish these individuals. These individuals are much less likely to perform capillary glucose monitoring, suggesting that their diabetes self-management is inadequate. Clinicians may be... |
### Instruction:
Are mutations of CXorf6 associated with a range of severities of hypospadias?
### Response:
| CXorf6 mutations are associated with isolated hypospadias of varying severity. However, the pathophysiology of these mutations and the function of the CXorf6 gene product remain to be investigated. |
### Instruction:
Is mild hyperhomocysteinemia associated with increased TAFI levels and reduced plasma fibrinolytic potential?
### Response:
| We describe an enhanced TAFI-related antifibrinolytic activity in mild HHcy, which might account for the reported heightened thrombosis risk; however, it is unknown whether HHcy is causally related to hypofibrinolysis or an associated bystander. |
### Instruction:
Does transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhance hepatocellular proliferation in young mice only?
### Response:
| Therefore, additional mechanisms such as enhanced growth factor expression or impaired negative feedback control mechanisms may augment IRS-1 overexpression in human hepatocarcinogenesis. |
### Instruction:
Is plasma homocysteine level elevated in patients on isotretinoin therapy for cystic acne : a prospective controlled study?
### Response:
| Hcy levels are elevated in patients on Iso treatment for CA. It may be due to either the inhibition of cystathionine-beta-synthase, an enzyme required in the metabolism of Hcy, by the drug and/or the liver dysfunction. Daily supplementation with vitamin B12 and folate, which are the cofactors of the enzymatic reactions... |
### Instruction:
Do hemodynamics at rest match clinical improvement after surgical ventricular restoration?
### Response:
| Invasive hemodynamic measurements under resting conditions do not correspond well to the significant clinical improvement noted in these patients. Studies during exercise conditions are necessary to further evaluate this procedure. |
### Instruction:
Does no touch vein harvesting technique for CABG improve the long-term clinical outcome?
### Response:
| The results of the NT-technique are encouraging with no cardiac deaths, significantly more asymptomatic patients and a trend towards impact on hard clinical endpoints compared to the conventional technique. |
### Instruction:
Do diastolic function and BNP changes during exercise predict oxygen consumption in chronic heart failure patients?
### Response:
| In CHF patients, E/Ea ratio is a predictor of exercise tolerance and is related with BNP level at rest and at peak exercise. |
### Instruction:
Is metabolic syndrome associated with self-perceived depression?
### Response:
| Elevated plasma glucose in men and central obesity in women are associated with self-perceived depression. This co-occurrence deserves attention in clinical practice. |
### Instruction:
Does the epidermal growth factor receptor ligand amphiregulin participate in the development of mouse liver fibrosis?
### Response:
| These results indicate that among the different EGFR ligands, AR plays a specific role in liver fibrosis. AR may contribute to the expression of fibrogenic mediators, as well as to the growth and survival of fibrogenic cells. Additionally, our data lend further support to the role of the EGFR system in hepatic fibrogen... |
### Instruction:
Is headache disability in orofacial pain patients related to traumatic life events?
### Response:
| This is the first study to demonstrate that headache disability is significantly higher in a group of orofacial pain patients with TLEs and is correlated with that report of traumatic events. These findings clearly demonstrate the necessity for providers to consider a history of TLEs in orofacial pain patients presenti... |
### Instruction:
Does right lateral position affect gastric transit times of video capsule endoscopy : a prospective study?
### Response:
| Only outpatients were included. |
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