question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Does the JNK inhibitor SP600129 enhance apoptosis of HCC cells induced by the tumor suppressor WWOX?
### Response:
| WWOX induces apoptosis and inhibits human HCC cell growth through a mechanism enhanced by JNK inhibition. |
### Instruction:
Does surfactant protein D protect against acute hyperoxic lung injury?
### Response:
| Local expression of SP-D protects against hyperoxic lung injury through modulation of proinflammatory cytokines and antioxidant enzymatic scavenger systems. |
### Instruction:
Does dasatinib exert an immunosuppressive effect on CD8+ T cells specific for viral and leukemia antigens?
### Response:
| Our study demonstrated that dasatinib impaired proliferation and function of CD8+T cells via TCR and NF-kappaB signaling events without inducing apoptosis. Therefore, dasatinib might alter the graft-vs-leukemia effect and the graft-vs-host disease after allogeneic stem cell transplantation sustained by CD8+T cells. Das... |
### Instruction:
Do mesenchymal stromal cells lose their immunosuppressive potential after allotransplantation?
### Response:
| MSCs lose their immunosuppressive potential in mismatched setting. |
### Instruction:
Does aKR-501 ( YM477 ) in combination with thrombopoietin enhance human megakaryocytopoiesis?
### Response:
| This study suggests that AKR-501 would be useful for the treatment of thrombocytopenia even at high plasma levels of endogenous TPO following chemotherapy. |
### Instruction:
Does dasatinib inhibit the growth and survival of neoplastic human eosinophils ( EOL-1 ) through targeting of FIP1L1-PDGFRalpha?
### Response:
| Dasatinib inhibits the growth of leukemic eosinophils through targeting of the disease-related oncoprotein FIP1L1-PDGFRalpha. Based on this observation, dasatinib may be considered as a new interesting treatment option for patients with CEL. |
### Instruction:
Does financial strain predict recurrent events among women with coronary artery disease?
### Response:
| Financial strain was a predictor for recurrent events among women with CAD, independently of commonly used SES indicators such as education and household income. Future studies will have to explore the mechanism behind this association. |
### Instruction:
Does adriamycin-induced autophagic cardiomyocyte death play a pathogenic role in a rat model of heart failure?
### Response:
| Autophagic cardiomyocyte death plays an important role in the pathogenesis of heart failure in rats induced by adriamycin. Mitochondrial injury may be involved in the progression of heart failure caused by adriamycin via the autophagy pathway. |
### Instruction:
Is hypermethylation of epithelial-cadherin gene promoter associated with Epstein-Barr virus in nasopharyngeal carcinoma?
### Response:
| The high incidence of EBV with the consistency of E-cadherin hypermethylation, particularly in undifferentiated and non-keratinizing NPC suggests the role of EBV in the hypermethylation. EBV exists at early stage of NPC that induces the hypermethylation and contributes to progression of the disease to the advanced stag... |
### Instruction:
Is the Arabidopsis thaliana response regulator ARR22 a putative AHP phospho-histidine phosphatase expressed in the chalaza of developing seeds?
### Response:
| Our results favor the model that ARR22 acts as a phospho-histidine phosphatase on specific AHPs in the cytoplasm of Arabidopsis chalaza cells. The lack of any aberrant morphological and metabolite phenotype in the seeds of the arr22 mutants indicates that ARR22 is probably primarily responsible for the fine tuning of s... |
### Instruction:
Does intrahepatic murine CD8 T-cell activation associate with a distinct phenotype leading to Bim-dependent death?
### Response:
| This study identifies Bim for the first time as a critical initiator of T-cell death in the liver. Thus, strategies inhibiting the up-regulation of this molecule could potentially be used to rescue CD8 T cells, clear the virus, and reverse the outcome of viral chronic infections affecting the liver. |
### Instruction:
Does rNA interfering connective tissue growth factor prevent rat hepatic stellate cell activation and extracellular matrix production?
### Response:
| CTGF siRNA could effectively and sequence-specifically down-regulate the expression of CTGF in rat HSC, resulting in significant inhibition of HSC activation and proliferation as well as ECM production. These findings indicate that synthetic siRNA targeting CTGF could prove to be a useful treatment of liver fibrosis. |
### Instruction:
Are cortical alpha rhythms related to the anticipation of sensorimotor interaction between painful stimuli and movements : a high-resolution EEG study?
### Response:
| We showed that cortical alpha rhythms preceding painful stimulation are influenced by the preparation of contralateral and ipsilateral finger movements. These results motivate further investigation for testing the hypothesis that chronic pain patients might exaggerate the anticipatory activation of sensorimotor cortex ... |
### Instruction:
Do defects in actin dynamics lead to an autoinflammatory condition through the upregulation of CXCL5?
### Response:
| This study shows that severe defects in actin dynamics lead to an autoinflammatory condition that is mediated by the expression of CXC chemokines. |
### Instruction:
Do orienteers with poor colour vision require more than cunning running?
### Response:
| Orienteers with more severe forms of abnormal colour vision are likely to be disadvantaged by their inability to differentiate some colours used on orienteering maps. The IOF should choose different colours that are less likely to be confused or should employ a redundant code (such as a pattern or texture). There is ne... |
### Instruction:
Does the metabolic syndrome identify a heterogeneous group of metabolic component combinations in the Asia-Pacific region?
### Response:
| The large variation in the prevalence of possible MetS component combinations to diagnose MetS may explain the different risk of cardiovascular outcomes associated with MetS in different populations, especially since particular combinations of MetS components are associated with different risk of cardiovascular disease... |
### Instruction:
Does cXCR-4 knockdown by small interfering RNA inhibit cell proliferation and invasion of oral squamous cell carcinoma cells?
### Response:
| These results suggest that the downregulation of CXCR-4 induces anti-proliferative and anti-invasive effects in OSCC and that CXCR-4 might be a useful target molecule for the treatment of OSCC. |
### Instruction:
Are serum interleukin-8 levels elevated in patients with ovarian endometrioma?
### Response:
| Measuring of serum IL-8 concentration may be a valuable tool in diagnosing endometriosis. |
### Instruction:
Is mal d 2 , the thaumatin-like allergen from apple , highly resistant to gastrointestinal digestion and thermal processing?
### Response:
| Our findings suggest that Mal d 2 maintains its structure in the gastrointestinal tract, a feature essential for sensitizing the mucosal immune system and provoking allergic reactions. |
### Instruction:
Does intravenous immune globulin reduce the need for exchange transfusions in Rhesus and AB0 incompatibility?
### Response:
| This study supports the evidence from previous studies suggesting that intravenous immune globulin significantly reduces the need for exchange transfusion in infants with Rhesus and AB0 incompatibility. |
### Instruction:
Does brain derived neurotrophic factor ( BDNF ) contribute to the pain hypersensitivity following surgical incision in the rats?
### Response:
| The present study showed that incision induced the segmental upregulation of BDNF in the DRG and spinal cord through somatic afferent nerve transmission, and the upregulated BDNF contributed to the pain hypersensitivity induced by surgical incision. |
### Instruction:
Does surgery for chronic Achilles tendinopathy produce worse results in women?
### Response:
| Females experience more prolonged recovery, more complications, and a greater risk of further surgery than males with recalcitrant Achilles tendinopathy. |
### Instruction:
Does hepatocyte growth factor gene transfer with naked plasmid DNA ameliorate dimethylnitrosamine-induced liver fibrosis in rats?
### Response:
| The hepatic arterial injection of human naked plasmid HGF DNA was effective in suppressing liver fibrosis induced in rats by DMN. The mechanisms by which HGF expression attenuated liver fibrosis may include the suppression of hepatic TGF-beta expression and the induction of MMP expression. |
### Instruction:
Does histone deacetylase inhibitor panobinostat induce clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma?
### Response:
| Panobinostat is well tolerated and induces clinical responses in CTCL patients. Microarray analyses of tumor samples indicate that panobinostat induces rapid changes in gene expression, and surprisingly more genes are repressed than are activated. A unique set of genes that can mediate biological responses such as apop... |
### Instruction:
Does aBCB1 genetic variation influence the toxicity and clinical outcome of patients with androgen-independent prostate cancer treated with docetaxel?
### Response:
| The data suggest that docetaxel-induced neuropathy, neutropenia grade, and overall survival could be linked to ABCB1 allelic variants with ensuing negative implications for docetaxel treatment in patients carrying ABCB1 variant genotypes. |
### Instruction:
Does local administration of PF-3512676 CpG-B instigate tumor-specific CD8+ T-cell reactivity in melanoma patients?
### Response:
| These data show an increase in melanoma-specific CD8(+) T-cell frequencies as well as an increased effector NK cell rate after a single dose of PF-3512676 and thus support the utility of local PF-3512676 administration as adjuvant treatment in early-stage melanoma to try and halt metastatic spread. |
### Instruction:
Does nuclear beta-catenin expression at the invasive front and in the vessels predict liver metastasis in colorectal carcinoma?
### Response:
| Nuclear accumulation of beta-catenin in cellular cells at the invasive front and in the vessels was the most powerful predictor of liver metastasis in colorectal cancer. This may be an important marker in the selection of patients for adjuvant therapy or other treatment modalities. |
### Instruction:
Does opioid receptor PET reveal the psychobiologic correlates of reward processing?
### Response:
| In healthy subjects, personality traits, which might be predisposing for addictive behavior, are correlated to the opioidergic neurotransmission in core structures of the human reward system. |
### Instruction:
Is 111In-octreotide superior to 123I-metaiodobenzylguanidine for scintigraphic detection of head and neck paragangliomas?
### Response:
| SRS was superior to MIBG in patients with highly suspected head and neck paraganglioma. |
### Instruction:
Do nuptial gifts fail to resolve a sexual conflict in an insect?
### Response:
| These results indicate that nutrient provisioning does not provide a resolution to sexual conflict over female receptivity in this bushcricket species. |
### Instruction:
Does prior SO2 exposure promote airway inflammation and subepithelial fibrosis following repeated ovalbumin challenge?
### Response:
| This data demonstrated that SEF developed in parallel with severity and time course of CAAI following repeated OVA challenge. SO(2)-induced acute epithelial injury and neutrophilic inflammation could enhance CAAI and promote SEF, probably through overexpression of ET-1 and TGF-beta1. |
### Instruction:
Do weight and body mass index predict bone mineral density and fractures in women aged 40 to 59 years?
### Response:
| Low weight and BMI predict osteoporosis and are associated with increased fracture risk in younger women. The negative impact of low body weight on bone health should be more widely recognized. |
### Instruction:
Does deficiency of alpha7 cholinergic receptors facilitate bacterial clearance in Escherichia coli peritonitis?
### Response:
| Deficiency of the alpha7 receptor is associated with an accelerated clearance of E. coli after intraperitoneal infection, preceded by a faster recruitment of neutrophils. These data provide the first evidence for a detrimental role of alpha7 receptors in the host defense against bacteria. |
### Instruction:
Does hIV-1 persist in breast milk cells despite antiretroviral treatment to prevent mother-to-child transmission?
### Response:
| Cell-free and, to a lesser extent, cell-associated HIV-1 RNA levels in breast milk were suppressed by antiretroviral regimens used to prevent MTCT. However, even with HAART, there was no significant reduction in the reservoir of infected cells, which could contribute to breast milk HIV-1 transmission. |
### Instruction:
Is blood donation an act of benevolence rather than altruism?
### Response:
| The benevolence hypothesis is supported, suggesting that blood donor motivation is partly selfish. Blood donation campaigns should focus on benevolent rather than purely altruistic messages. |
### Instruction:
Do the origin and evolution of plant cystatins and their target cysteine proteinases indicate a complex functional relationship?
### Response:
| Comparative genomic analyses have provided us valuable insights into the conservation and evolution of the cystatin inhibitory family and their putative targets, the cysteine proteinases from families C1A and C13. Functionality of both families of proteins in plants must be the result of a coevolutionary process that m... |
### Instruction:
Do modulators of calcium influx regulate membrane excitability in rat dorsal root ganglion neurons?
### Response:
| Taken together, our findings show that suppression of I(Ca) decreases the AHP, reduces the hyperpolarization-induced voltage sag, and increases excitability in sensory neurons, replicating changes that follow peripheral nerve trauma. This suggests that the loss of I(Ca) previously demonstrated in injured sensory neuron... |
### Instruction:
Does prolonged use of high-dose morphine impair angiogenesis and mobilization of endothelial progenitor cells in mice?
### Response:
| High-dose morphine impaired angiogenesis, increased systemic oxidative stress, and impaired mobilization of endothelial progenitor cells. This study emphasizes the potential detrimental effect of high-dose morphine on angiogenesis after systemic administration. |
### Instruction:
Is evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia confounded by study quality?
### Response:
| The reported efficacy of NXY-059 in animal models of stroke is confounded by low study quality. The failure of SAINT II highlights the need for substantial improvements in the design, conduct, and reporting of animal studies; journals can play an important role in this by adopting standards for animal studies similar t... |
### Instruction:
Do low vitamin d levels predict stroke in patients referred to coronary angiography?
### Response:
| Low levels of 25(OH)D and 1,25(OH)2D are independently predictive for fatal strokes, suggesting that vitamin D supplementation is a promising approach in the prevention of strokes. |
### Instruction:
Are cathepsin B , K , and S expressed in cerebral aneurysms and promote the progression of cerebral aneurysms?
### Response:
| Data obtained by using NC-2300 revealed an important role of cysteine cathepsins in the progression of CAs. Our findings strongly suggest that an imbalance between cysteine cathepsins and their inhibitor may cause the excessive breakdown of extracellular matrix in the arterial walls leading to the progression and ruptu... |
### Instruction:
Is community socioeconomic status associated with circulating interleukin-6 and C-reactive protein?
### Response:
| Independent of personal income or educational attainment, midlife adults living in less advantaged neighborhoods exhibit higher levels of circulating proinflammatory markers than residents of more affluent areas. This association may help explain the increased risk of atherosclerotic cardiovascular morbidity and mortal... |
### Instruction:
Does preoperative irradiation with 5 x 5 Gy in a murine isolated colon loop model cause anastomotic weakening after colon resection?
### Response:
| We developed a new isolated loop model for intermittent irradiation of the colon. Preoperative irradiation of the distal part of a colon anastomosis was successfully administered with acceptable side effects and did not cause reduced tissue oxygenation nor clinical signs of anastomotic weakening, nor objective reductio... |
### Instruction:
Does anti-inflammatory therapy with tumour necrosis factor alpha inhibitors improve high-density lipoprotein cholesterol antioxidative capacity in rheumatoid arthritis patients?
### Response:
| Anti-TNF therapy with infliximab has beneficial effects on lipids through changes in HDL antioxidative capacity, which might be clinically relevant and contribute to the reported protective effect of anti-TNF on cardiovascular morbidity in RA. This emphasises the importance of HDL antiatherogenic capacity for cardiovas... |
### Instruction:
Is variation in bone morphogenetic protein 15 associated with spontaneous human dizygotic twinning?
### Response:
| We conclude that neither rare nor common BMP15 variants play a significant role in the variation in human DZ twinning. |
### Instruction:
Does intraarticular tramadol-bupivacaine combination prolong the duration of postoperative analgesia after outpatient arthroscopic knee surgery?
### Response:
| The IA admixture of tramadol 100 mg with bupivacaine 0.25% provides a pronounced prolongation of analgesia compared with either drug alone in patients undergoing day care arthroscopic knee surgery. |
### Instruction:
Does patellofemoral compressive force and stress during the forward and side lunge with and without a stride?
### Response:
| A more functional knee flexion range between 0 degrees and 50 degrees may be appropriate during the early phases of patellofemoral rehabilitation due to lower patellofemoral compressive force and stress during this range compared to higher knee angles between 60 degrees and 90 degrees. Moreover, when the goal is to min... |
### Instruction:
Does increased immune reactivity predict aggressive complicating Crohn 's disease in children?
### Response:
| The rate of complicated CD increases in children as the number and magnitude of immune reactivity increase. Disease progression is significantly faster in children expressing immune reactivity. |
### Instruction:
Do cortical responses to Mozart 's sonata enhance spatial-reasoning ability?
### Response:
| We suggest the possibility of a direct priming effect being responsible for preferential activation, and open the door to understanding the potential effects of Mozart's music. |
### Instruction:
Are nicotinic acetylcholine receptor subunit variants associated with blood pressure ; findings in the Old Order Amish and replication in the Framingham Heart Study?
### Response:
| CHRNG is currently thought to be expressed only during fetal development. These findings support the Barker hypothesis, that fetal genotype and intra-uterine environment influence susceptibility to chronic diseases later in life. Additional studies of this variant in other populations, as well as the effect of this var... |
### Instruction:
Are multidrug resistance-associated proteins crucial for the viability of activated rat hepatic stellate cells?
### Response:
| Activated HSCs contain relatively high levels of Mrp1. Mrp-type transporters are required for the viability of activated HSCs. Mrp-dependent export of endogenous metabolites is important for the survival of activated HSCs in chronic liver diseases. |
### Instruction:
Is modulation of microtubule assembly by the HIV-1 Tat protein strongly dependent on zinc binding to Tat?
### Response:
| Our data suggest that holo-Tat corresponds to the active form, responsible for the Tat-mediated apoptosis. |
### Instruction:
Is the polycomb repressive complex 2 a potential target of SUMO modifications?
### Response:
| Taken together, our data identify sumoylation as a novel post-translational modification of components of the PRC2 complex, which could suggest a potential new mechanism to modulate PRC2 repressive activity. Further work aimed to identify the physiological conditions for these modifications will be required to understa... |
### Instruction:
Do histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling?
### Response:
| Our results demonstrate a transcriptionally-based regulation of BMP2/4 signaling by HDACs both in vivo and in vitro that is critical for neurogenesis in the ganglionic eminences and that modulates cortical neurogenesis. The results also suggest that HDACs may regulate the developmental switch from neurogenesis to astro... |
### Instruction:
Is the Charlson comorbidity index adapted to predict costs of chronic disease in primary care patients?
### Response:
| The adapted comorbidity index can be used to predict resource utilization. Predictive models may help to identify targets for reducing high costs, by prospectively identifying those at high risk. |
### Instruction:
Is long-term comorbidity of diabetes mellitus a risk factor for perineal wound complications after an abdominoperineal resection?
### Response:
| This study demonstrated diabetes mellitus to be independently associated with perineal wound complications, and when the patients have diabetes mellitus, especially with a longer comorbid duration and longer operation time, the clinical path should be changed to reduce perineal wound complications. |
### Instruction:
Is dinucleotide repeat polymorphism in Fms-like tyrosine kinase-1 ( Flt-1 ) gene associated with preeclampsia?
### Response:
| This is the first study to characterize the dinucleotide repeat polymorphism of the Flt-1 gene in patients with preeclampsia. We found no differences in the allele or genotype frequencies between patients with preeclampsia and normal pregnancies. Although limited by a relatively small sample size, our study suggests th... |
### Instruction:
Does lower extremity muscle mass predict functional performance in mobility-limited elders?
### Response:
| These data suggest that lower extremity muscle mass is an important determinant of physical performance among functionally-limited elders. Such findings may have important implications for the design of suitable strategies to maintain independence in older adults with compromised physical functioning. Additional studie... |
### Instruction:
Is colonoscopy the preferred colorectal cancer screening method in a population-based program?
### Response:
| In this population-based study, only a small proportion of the target population underwent CRC screening despite an extensive information campaign. Colonoscopy was the preferred method and was safe. The determinants of participation in screening and preference of screening method, together with the distribution of colo... |
### Instruction:
Do effects of gaze strategy on standing postural stability in older multifocal wearers?
### Response:
| Multifocal use had no effect on standing postural stability. Irrespective of spectacles worn, when fixating a visual target positioned at ground level, postural stability was better in the 'head flexed-gaze down' condition compared with the 'head neutral-gaze down' condition. A useful strategy to reduce falling in the ... |
### Instruction:
Is decreased recent thymus emigrant number associated with disease activity in systemic lupus erythematosus?
### Response:
| Our results reveal decreased TREC levels in the peripheral blood of patients with active but not in patients with quiescent SLE. These data suggest that TREC levels are affected by disease activity in SLE. |
### Instruction:
Does estrogen supplementation selectively enhance hypothalamo-pituitary sensitivity to ghrelin in postmenopausal women?
### Response:
| Transdermal E(2) supplementation potentiates GH secretion stimulated by physiological but not pharmacological concentrations of acylated ghrelin, and concomitantly regularizes patterns of bioactive ghrelin secretion in postmenopausal women. Accordingly, the estrogen milieu appears to control sensitivity of the hypothal... |
### Instruction:
Does eEF2 analysis challenge the monophyly of Archaeplastida and Chromalveolata?
### Response:
| Our EEF2 analysis strongly refutes the monophyly of the Archaeplastida and the Chromalveolata, adding to a growing body of evidence that limits the utility of these supergroups. In view of EEF2 phylogeny and other morphological evidence, we discuss the possibility of an alternative eukaryotic supergroup. |
### Instruction:
Is regulator of G-protein signalling 4 expression altered in the prefrontal cortex in schizophrenia?
### Response:
| Altered RGS4 expression is not universally present throughout the cortex of people with schizophrenia. |
### Instruction:
Does absolute spike frequency predict surgical outcome in TLE with unilateral hippocampal atrophy?
### Response:
| This study identified absolute preoperative spike frequency as a strong predictor for surgical outcome, while relative spike distribution had no significant influence on postoperative seizure control. |
### Instruction:
Is expression of COX-2 associated with accumulation of p53 in pancreatic cancer : analysis of COX-2 and p53 expression in premalignant and malignant ductal pancreatic lesions?
### Response:
| These findings confirmed the generally accepted pancreatic cancer progression model, and supported the concept of the interactive role of COX-2 and p53 in pancreatic cancer carcinogenesis, which offers opportunities for targeted therapy and chemoprevention of pancreatic cancer using COX-2 inhibitors. |
### Instruction:
Is the SPINK1 N34S variant associated with acute pancreatitis?
### Response:
| The SPINK1 N34S variant is associated with acute pancreatitis. This supports the importance of premature protease activation in the pathogenesis of AP and suggests that mutated SPINK1 may predispose certain individuals to develop this disease. |
### Instruction:
Is the V249I polymorphism of the CX3CR1 gene associated with fibrostenotic disease behavior in patients with Crohn 's disease?
### Response:
| In Crohn's disease, V249I CX3CR1 polymorphism is associated with intestinal strictures, particularly in smokers. This association is independent of CARD15 mutations. |
### Instruction:
Is a novel recombinant soluble splice variant of Met a potent antagonist of the hepatocyte growth factor/scatter factor-Met pathway?
### Response:
| Taken together, our results indicate that Cgen-241A is a potent antagonist of the HGF/SF-Met pathway, underlining its potential as a therapeutic agent for the treatment of a wide variety of human malignancies that are dependent on this pathway. |
### Instruction:
Is kML001 cytotoxic activity associated with its binding to telomeric sequences and telomere erosion in prostate cancer cells?
### Response:
| Sodium metaarsenite is a telomere targeting agent and should be explored for the treatment of tumors with short telomeres. |
### Instruction:
Is the CO-releasing molecule CORM-2 a novel regulator of the inflammatory process in osteoarthritic chondrocytes?
### Response:
| These data have opened new mechanisms of action for CORM-2, raising the prospect that CO-releasing molecules are an interesting strategy for the development of new treatments in articular conditions. |
### Instruction:
Is the CYP19 TTTA repeat polymorphism related to the prognosis of premenopausal stage I-II and operable stage III breast cancers?
### Response:
| The CYP19 TTTA repeat polymorphism is associated with survival in premenopausal women, but not in postmenopausal women, with HR-positive breast cancers. Premenopausal women with the long allele have a greater survival rate and may not gain benefit from adjuvant chemotherapy. |
### Instruction:
Are left atrial linear lesions required for successful treatment of persistent atrial fibrillation?
### Response:
| Although persistent AF can be terminated by catheter ablation without linear lesions, the majority will require linear lesions for macro re-entrant AT. |
### Instruction:
Does [ FK228 promote the IL-3 mediated proliferation and differentiation of human erythroid progenitor cells ]?
### Response:
| FK228 can promote the IL-3 mediated proliferation and differentiation of human erythroid progenitor cells. |
### Instruction:
Are iL-8 and p53 inversely regulated through JNK , p38 and NF-kappaB p65 in HepG2 cells during an inflammatory response?
### Response:
| Our results indicate that IL-8 and p53 protein expression is regulated through inverse activation of the p38 MAPK and the JNK pathways and the NF-kappaB p65 expression. |
### Instruction:
Is downregulation of SIAH2 , an ubiquitin E3 ligase , associated with resistance to endocrine therapy in breast cancer?
### Response:
| In primary breast tumor specimens as well as in vitro low SIAH2 levels associated with resistance to endocrine therapy. Moreover, SIAH2 expression showed an opposite regulation by E2 and EGF. |
### Instruction:
Does human Sgo1 downregulation lead to chromosomal instability in colorectal cancer?
### Response:
| These findings suggest that hSgo1-downregulated colorectal cancers have a clinicopathological character of CIN, and hSgo1 downregulation leads to CIN in colorectal cancer cells. |
### Instruction:
Do nanoparticulate fillers improve the mechanical strength of bone cement?
### Response:
| In summary, nanoparticulate substitution of radiopacifiers substantially improved the in vitro mechanical properties of PMMA bone cement without changing the known chemical composition. |
### Instruction:
Are anti-A and anti-B titers in pooled group O platelets comparable to apheresis platelets?
### Response:
| Anti-A and anti-B titers in group O PPLTs are comparable to those reported in group O SDPs and significantly lower than titers reported in AHTR. A critical direct agglutinin titer of 64 for identifying high-titer units by gel is too low and should be increased to 128 or higher. |
### Instruction:
Is immunoblotting using multiple antigens essential to demonstrate the true risk of Helicobacter pylori infection for gastric cancer?
### Response:
| Immunoblotting improves the accuracy of H. pylori studies involving gastric cancer. |
### Instruction:
Does parental perceptions of being told their child have cancer?
### Response:
| The majority of parents recall receiving the diagnosis and the discussions that ensued about their child's diagnosis of cancer. Most parents were satisfied with their experience with receiving the diagnosis. Suggestions for improvement can be incorporated into future educational indicatives for front line healthcare pr... |
### Instruction:
Are cytomegalovirus and Epstein-Barr virus in breast milk associated with HIV-1 shedding but not with mastitis?
### Response:
| Coinfection of breast milk with bacteria, fungi, or herpes viruses was not associated with mastitis. The associations between shedding of cytomegalovirus and Epstein-Barr virus with HIV-1 in milk suggest a local interaction between herpes virus infection and HIV-1 independent of mastitis. Cytomegalovirus and Epstein-Ba... |
### Instruction:
Does palonosetron exhibit unique molecular interactions with the 5-HT3 receptor?
### Response:
| Palonosetron exhibited allosteric binding and positive cooperativity when binding to the 5-HT(3) receptor. Palonosetron also triggered functional effects that persisted beyond its binding to the 5-HT(3) receptor at the cell surface. Differences in binding and effects on receptor function may be relevant to the unique b... |
### Instruction:
Do general anesthetics have additive actions on three ligand gated ion channels?
### Response:
| The simultaneous allosteric modulation of ligand gated ion channels by general anesthetics is entirely additive. Where pairs of general anesthetic drugs interact synergistically to produce general anesthesia, they must do so on systems more complex than a single receptor. |
### Instruction:
Do inhaled anesthetics combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats?
### Response:
| Such results are consistent with the notion that inhaled anesthetics act on a single site to produce immobility in the face of noxious stimulation. |
### Instruction:
Does upper-body progressive resistance training improve strength and household physical activity performance in women attending cardiac rehabilitation?
### Response:
| Progressive upper-body RT in women shows promise as an effective tool to increase muscle strength and improve the ability to perform HPA after a cardiac event. Beginning RT early after a cardiac event in a monitored cardiac rehabilitation environment can maximize the strengthening benefit. |
### Instruction:
Does single histidine-substituted cardiac troponin I confer protection from age-related systolic and diastolic dysfunction?
### Response:
| This study shows that increasing myofilament function by means of a pH-responsive histidine button engineered into cTnI results in enhanced baseline heart function in Tg mice over their lifetime, and during acute hypoxia improves survival in aged mice by maintaining cardiac contractility. |
### Instruction:
Does hypercapnic acidosis minimize endotoxin-induced gut mucosal injury in rabbits?
### Response:
| Hypercapnic acidosis attenuates endotoxin-induced gut barrier dysfunction possibly through neutrophil-independent mechanisms. |
### Instruction:
Does a multiple-day regimen of parecoxib sodium 20 mg twice daily provide pain relief after total hip arthroplasty?
### Response:
| Multiple-day administration of parecoxib 20 mg once or twice daily is effective and generally well tolerated after total hip arthroplasty. |
### Instruction:
Does tissue-engineered spleen protect against overwhelming pneumococcal sepsis in a rodent model?
### Response:
| TES is a novel application of tissue engineering to splenic regeneration and creates a functional spleen. This approach could be advantageous in severe pediatric trauma. |
### Instruction:
Does iGF-I receptor inhibition combined with rapamycin or temsirolimus inhibit neuroblastoma cell growth?
### Response:
| The combination of rapamycin or temsirolimus with alphaIR3 blocks the IGF1R signaling pathway and has an antiproliferative effect on neuroblastoma cells warranting further investigations using inhibitors of IGF1R signaling as novel combination therapy for neuroblastoma. |
### Instruction:
Does sulfasalazine block the development of tactile allodynia in diabetic rats?
### Response:
| The complete inhibition of tactile allodynia in experimental diabetes by sulfasalazine may stem from its ability to regulate both NF-kappaB and inosine. Sulfasalazine might be useful in the treatment of nociceptive alterations in diabetic patients. |
### Instruction:
Is diurnal variation of human sweet taste recognition thresholds correlated with plasma leptin levels?
### Response:
| This synchronization of diurnal variation in leptin levels and sweet taste recognition thresholds suggests a mechanistic connection between these two variables in humans. |
### Instruction:
Do alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction?
### Response:
| Our findings suggest that at least part of the detrimental effects of palmitate on beta-cells is caused by alterations in the level of specific miRNAs. |
### Instruction:
Do genetic tests of ancient asexuality in root knot nematodes reveal recent hybrid origins?
### Response:
| The data strongly suggests the tropical root knot nematode apomicts have a recent origin and are not anciently asexual. The results support that interspecific hybridization has been involved in the origin of this asexual group and has played a role in shaping the patterns of genetic diversity observed. This study sugge... |
### Instruction:
Does [ Promoter methylation regulate KIR3DL1 gene expression in NK-92MI cell line ]?
### Response:
| KIR3DL1 expression in NK-92MI cells is regulated by promoter methylation. |
### Instruction:
Do natriuretic peptides modify Pseudomonas fluorescens cytotoxicity by regulating cyclic nucleotides and modifying LPS structure?
### Response:
| These observations support the hypothesis that P. fluorescens responds to natriuretic peptides through a putative sensor system coupled to a cyclase that could interfere with LPS synthesis and thereby modify the overall virulence of the micro-organism. |
### Instruction:
Do prelimbic and infralimbic prefrontal cortex interact during fast network oscillations?
### Response:
| Our data indicate that neuronal networks of prelimbic and infralimbic cortex can sustain fast network oscillations independent of each other, but suggest that neuronal networks of prelimbic and infralimbic cortex are interacting during these oscillations. |
### Instruction:
Does aIP4/Itch regulate Notch receptor degradation in the absence of ligand?
### Response:
| Taken together our results identify a specific step of Notch regulation in the absence of any activation and underline differences between mammalian and Drosophila Notch pathways. |
### Instruction:
Does a 28,000 years old Cro-Magnon mtDNA sequence differ from all potentially contaminating modern sequences?
### Response:
| The Paglicci 23 individual carried a mtDNA sequence that is still common in Europe, and which radically differs from those of the almost contemporary Neandertals, demonstrating a genealogical continuity across 28,000 years, from Cro-Magnoid to modern Europeans. Because all potential sources of modern DNA contamination ... |
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