question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Is the contribution of splanchnic fat to VLDL triglyceride greater in insulin-resistant than insulin-sensitive men and women : studies in the postprandial state?
### Response:
| In the postprandial period, the only sources of fatty acids for VLDL TG production to differ in the insulin-resistant compared with the insulin-sensitive men are those derived from splanchnic sources. |
### Instruction:
Do urgency of surgery and presence of maternal disease influence the choice of anaesthesia for Caesarean section at LUTH?
### Response:
| The choice of anaesthesia depends on the urgency of surgery and the medical condition of the mother. General anaesthesia was more likely to be administered for bleeding emergencies and foetal distress. Spinal anaesthesia was preferred for elective and urgent cases or when maternal disease existed. |
### Instruction:
Are child-feeding strategies associated with maternal concern about children becoming overweight , but not children 's weight status?
### Response:
| Mothers concerned about their child becoming overweight were more likely to restrict children's intake of specific foods and less likely to pressure their child to eat; however, this study did not detect an association between feeding strategies and child overweight. |
### Instruction:
Do igG antibody responses to Plasmodium falciparum merozoite antigens in Kenyan children have a short half-life?
### Response:
| This study indicates antibodies against merozoite antigens have very short half-lives and this has to be taken into account when designing serological studies and vaccines based on the antigens. |
### Instruction:
Does epidermal growth factor receptor ( EGFR ) mutation correlate with platinum resistance in ovarian carcinoma . Results of a prospective pilot study?
### Response:
| Mutations in the kinase domain of the EGFR, exons 19 and 21, are absent or very infrequent in patients with OC. |
### Instruction:
Are interactions among genes in the ErbB-Neuregulin signalling network associated with increased susceptibility to schizophrenia?
### Response:
| These new findings suggest that observed associations between NRG1 and schizophrenia may be mediated through functional interaction not just with ERBB4, but with other members of the NRG and ERBB families. There is evidence that genetic interaction among these loci may increase susceptibility to schizophrenia. |
### Instruction:
Does low-grade dysplasia in Barrett 's esophagus have a high risk of progression?
### Response:
| Patients diagnosed with LGD during surveillance of Barrett's esophagus are at a considerably increased risk of progressing to develop esophageal cancer over an 8-year period but most deaths are not cancer-related. |
### Instruction:
Does estrogen-eluting stent implantation inhibit neointimal formation and extracellular signal-regulated kinase activation?
### Response:
| Current study suggests that estrogen-eluting stents reduce neointimal formation and hence prevent restenosis after angioplasty possibly by inhibiting ERK activation in smooth muscle cells and promoting reendothelialization. |
### Instruction:
Does local insulin-zinc injection accelerate skin donor site wound healing?
### Response:
| Local injection of long-acting insulin-zinc suspension accelerated skin wound healing without major systemic side effects, demonstrating its potential usefulness in burn treatment. |
### Instruction:
Does baroreflex sensitivity correlate with left ventricular morphology and diastolic function in essential hypertension?
### Response:
| BRS is associated with left ventricular morphology, systolic and diastolic function in hypertensive patients. In particular BRS is impaired in patients with diastolic dysfunction. These findings suggest a role for BRS as a target in arterial hypertension. |
### Instruction:
Do kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages?
### Response:
| Both diterpenes protected macrophages from apoptosis and inhibited phagocytosis, resulting in a paradoxical control of macrophage function, as viability was prolonged but inflammatory and phagocytic functions were impaired. |
### Instruction:
Is tumor size a major determinant of recurrence in patients with resectable gastrointestinal stromal tumor?
### Response:
| We concluded that tumor size > or = 10 cm carried both a higher risk of recurrence and worse survival in resectable GISTs and could be considered an indicator for adjuvant therapy. |
### Instruction:
Are iL-5 and IL-5 receptor alpha polymorphisms associated with atopic dermatitis in Koreans?
### Response:
| We found that the rs2522411SNP and the haplotype T-A in the IL-5 gene and the serum IL-5 levels were strongly associated with the allergic type of AD, but not with the nonallergic type of AD. The association of the rs6771148SNP and the haplotype T-C-T in the IL5RA gene with the blood eosinophil counts and the serum ECP... |
### Instruction:
Does prolonged preseasonal treatment phase with Grazax sublingual immunotherapy increase clinical efficacy?
### Response:
| Sublingual immunotherapy with Grazax) must be initiated at least 8 weeks prior to the grass pollen season to provide a significant clinical efficacy. A longer preseasonal treatment period (>8 weeks) improves the clinical efficacy (relative to placebo) during the grass pollen season. |
### Instruction:
Does angiography for blunt splenic trauma improve the success rate of nonoperative management?
### Response:
| Patients who underwent splenic arteriography did not have improved nonoperative splenic salvage rates compared with a contemporaneous control group of similarly injured patients. Subsets of patients with blunt trauma may benefit from SAE but further study will be required to define these patients. |
### Instruction:
Is low-dose chemotherapy practically useful for the patients with intrapelvic recurrence of rectal cancer?
### Response:
| The results suggest that low-dose chemotherapy for intrapelvic recurrence of rectal cancer without radiotherapy could be acceptable. For patients who refused radiotherapy in order to avoid adverse effects, these low-dose low toxicity chemotherapy regimens might be recommended. |
### Instruction:
Are vitamin D receptor gene polymorphisms associated with increased risk and progression of renal cell carcinoma in a Japanese population?
### Response:
| The AA genotype at the ApaI site of the VDR gene may be a risk of incidence and poor prognosis factor for RCC in the Japanese population. Additional studies with a large sample size and investigation of the functional significance of the ApaI polymorphism in RCC cells are warranted. |
### Instruction:
Is a haplotype spanning KIAA0319 and TTRAP associated with normal variation in reading and spelling ability?
### Response:
| These results suggest that a multilocus effect in or near KIAA0319 may influence variation in reading ability. |
### Instruction:
Does interaction between CRHR1 gene and stressful life events predict adolescent heavy alcohol use?
### Response:
| These findings provide first evidence in humans that the CRHR1 gene interacts with exposure to stressful life events to predict heavy alcohol use in adolescents. |
### Instruction:
Does the HDAC inhibitor trichostatin A inhibit growth of small cell lung cancer cells?
### Response:
| TSA causes morphological differentiation and dose-dependent inhibition of cell growth via cell cycle arrest and subsequent apoptosis. This suggests that TSA and other HDACIs may represent a new potential therapy for patients with SCLC. |
### Instruction:
Is multi-drug resistance 1 polymorphism associated with reduced risk of gastric cancer in the Japanese population?
### Response:
| Our data suggest that 3435T/T polymorphism of MDR1 is associated with a reduced risk of gastric cancer in the Japanese population. |
### Instruction:
Does levamisole inhibit sequestration of infected red blood cells in patients with falciparum malaria?
### Response:
| These findings strongly suggest that levamisole decreases iRBC sequestration in falciparum malaria in vivo and should be considered as a potential adjunctive treatment for severe falciparum malaria. |
### Instruction:
Is production of IL-12 by Peyer patch-dendritic cells critical for the resistance to food allergy?
### Response:
| Reciprocal T(H)1-T(H)2 control of DCs' function within the inductive site of the gut immune system is altered in food allergy. |
### Instruction:
Is screening of auramine-stained smears of all fecal samples a rapid and inexpensive way to increase the detection of coccidial infections?
### Response:
| The screening of all fecal samples with AuO-stained smears is a rapid and inexpensive way to increase the detection of coccidial infections, which in most laboratories can be incorporated into the microscopic workup for mycobacteria. |
### Instruction:
Are proliferation , angiogenesis and apoptosis-associated proteins molecular targets for chemoprevention of MNNG-induced gastric carcinogenesis by ethanolic Ocimum sanctum leaf extract?
### Response:
| This study provides evidence that, in MNNG-induced gastric carcinogenesis, the key proteins involved in the proliferation, invasion, angiogenesis and apoptosis, are viable molecular targets for chemoprevention using ethanolic OS leaf extract. |
### Instruction:
Are human leukocyte class I antigen alleles A2 and A11 associated with nasopharyngeal carcinoma in West Malaysia?
### Response:
| We conclude that A1 is very rare, and A2, A11, A31, A32, A33, B8, B13, B38, B39, B44, B46, B55, B58, B61 and B71 alleles have no associations with the occurrence of NPC in Malaysia, while allele B27 is negatively associated. |
### Instruction:
Does p38MAPK-activated AKT in HER-2 overexpressing human breast cancer cells act as an EGF-independent survival signal?
### Response:
| The data presented here indicate that AKT activation can compensate for EGF-mediated cell survival signals leading to growth factor independence and anchorage-independent growth. |
### Instruction:
Does ligation of ameroid-stenosed coronary artery lead to reproducible myocardial infarction -- a pilot study in a porcine model?
### Response:
| This new modification of ameroid model standardizes myocardial lesion, which might reduce animal number in preclinical studies, thus having ethical aspect. The remarked potential for spontaneous recovery in ischemic porcine myocardium should be considered in preclinical therapeutic studies. |
### Instruction:
Is bone marrow a preferential homing site for autoreactive T-cells in type 1 diabetes?
### Response:
| Our study demonstrates that a large number of diabetogenic T-cells are present in the bone marrow of female NOD mice and that these autoreactive T-cells can be detected long before clinical onset of the disease. |
### Instruction:
Does tCF7L2 rs7903146 variant associate with smallness for gestational age in the French population?
### Response:
| The TCF7L2 rs7903146 variant neither increases the risk for SGA nor modulates birth weight and young adulthood glucose homeostasis in French Caucasian subjects born with SGA. |
### Instruction:
Does long-term survival after lung transplantation depend on development and severity of bronchiolitis obliterans syndrome?
### Response:
| The development and progression of chronic allograft rejection after lung transplantation (BOS Grades 2 and 3) is associated with a 3-fold increase in the risk of death at each stage, irrespective of whether BOS developed early or late. |
### Instruction:
Is neurite outgrowth on a fibronectin isoform expressed during peripheral nerve regeneration mediated by the interaction of paxillin with alpha4beta1 integrins?
### Response:
| We establish the importance of the alpha4 integrin-paxillin interaction in a model of axonal regeneration and highlight differing dependence on phosphorylation of alpha4 for extension of neuronal growth cones and migration of non-neural cells. |
### Instruction:
Does a prolonged interval between deep intestinal ischemia and anastomotic construction impair wound strength in the rat?
### Response:
| Extending the interval between transient deep intestinal ischemia and construction of an anastomosis does not impair wound strength. |
### Instruction:
Are alpha1-adrenoceptors required for normal male sexual function?
### Response:
| These results demonstrate that alpha(1)-adrenoceptors, particularly alpha(1A)-adrenoceptors, are required for normal contractility of the vas deferens and consequent sperm ejaculation as well as having a function in fertility. |
### Instruction:
Does laparoscopic colorectal resection reduce incisional hernia rates when compared with open colorectal resection?
### Response:
| Laparoscopic colorectal resection does not appear to reduce incisional hernia rates when compared with open surgery. Large randomised trials are required to confirm these findings. |
### Instruction:
Does positive affect predict improved lip movement in facial movement disorder?
### Response:
| Positive affect predicts improved facial movement outcomes in patients with facial movement disorders. |
### Instruction:
Are tumor necrosis factor-alpha and oxidant status essential participating factors in unexplained recurrent spontaneous abortions?
### Response:
| Impaired antioxidant defense and an increase in oxidative reactive species may be responsible for recurrent abortion due to possible damage produced by their generation. In addition, the level of TNF-alpha apparently contributes to the pathogenesis of URSA. |
### Instruction:
Does timing affect the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis?
### Response:
| Within the limits of a retrospective analysis, these findings indicate that administration of amoxicillin/metronidazole immediately after initial SRP provides more PD reduction and RAL "gain" in initially deep sites than late administration at SPT with reinstrumentation after 3 months. |
### Instruction:
Are higher pre-infection vitamin E levels associated with higher mortality in HIV-1-infected Kenyan women : a prospective study?
### Response:
| Higher pre-infection vitamin E levels were associated with increased mortality. Further research is needed to elucidate the role vitamin E plays in HIV-1 pathogenesis. |
### Instruction:
Are plasma acylated ghrelin levels higher in patients with chronic atrophic gastritis?
### Response:
| The increase in acylated ghrelin levels and in the acylated/total ghrelin ratio in patients with atrophy of the body and fundus can be explained by hypothesizing an increase in the acylating process in the presence of gastric atrophy. It suggests that there may be a compensatory increase in plasma active ghrelin concen... |
### Instruction:
Does n-terminal probrain natriuretic peptide level inversely correlate with cardiac index after arterial switch operation in neonates?
### Response:
| NT-proBNP correlated with the hemodynamic parameters and with the severity of renal dysfunction. Therefore, NT-proBNP is a reliable indicator of the circulatory state and the severity of a low output syndrome after arterial switch operation in neonates. |
### Instruction:
Does leptin induce C-reactive protein expression in vascular endothelial cells?
### Response:
| Leptin induces CRP expression in HCAECs via activation of the leptin receptor, increased ROS production, and phosphorylation of ERK1/2. These studies suggest a mechanism for the proatherogenic effects of leptin. |
### Instruction:
Does iL13 promoter polymorphism 1112C/T modulate the adverse effect of tobacco smoking on lung function?
### Response:
| An IL13 polymorphism in the promoter region may modulate the adverse effects of cigarette smoking on pulmonary function in long-term cigarette smokers. |
### Instruction:
Do wild-type ApoA-I and the Milano variant have similar abilities to stimulate cellular lipid mobilization and efflux?
### Response:
| Collectively these studies suggest that if the Milano variant of apoA-I offers greater atheroprotection than wild-type apoA-I, it is not attributable to greater cellular lipid mobilization. |
### Instruction:
Is chronic hepatitis C virus infection associated with Mooren 's ulcer?
### Response:
| There was no association between chronic HCV infection and Mooren's ulcer in this limited case series study. |
### Instruction:
Is substernal thyroidectomy associated with increased morbidity and mortality as compared with conventional cervical thyroidectomy?
### Response:
| Substernal thyroidectomy, as compared with cervical thyroidectomy, is associated with a markedly increased likelihood of both postoperative complications and mortality. |
### Instruction:
Does peripheral infusion of rat bone marrow derived endothelial progenitor cells lead to homing in acute lung injury?
### Response:
| Transplanted EPC may play an important role in reestablishing the endothelial integrity in vessels after severe injury or at inflammatory sites and might further contribute to vascular repair or wound healing processes in severely damaged tissue. Therapeutic applications of EPC transplantation may ensue. |
### Instruction:
Is the structure of quality systems important to the process and outcome , an empirical study of 386 hospital departments in Sweden?
### Response:
| The model could be used to describe and evaluate single quality systems or to compare different quality systems. It could also be an aid to implement a systematic and evidence-based system for working with quality improvements in hospital departments. |
### Instruction:
Does p2Y1 receptor switch to neurons from glia in juvenile versus neonatal rat cerebellar cortex?
### Response:
| Membrane components including purinergic receptors are already known to mediate cellular contact and aggregation in platelets. Our results suggesting a potential role for P2Y1 protein in cell junction/communication and development, are totally innovative for the CNS. |
### Instruction:
Is diacylglycerol kinase required for HGF-induced invasiveness and anchorage-independent growth of MDA-MB-231 breast cancer cells?
### Response:
| Dgks could be a target for ER-negative breast cancer therapy. |
### Instruction:
Is a change in promoter methylation of hMLH1 a cause of acquired resistance to platinum-based chemotherapy in epithelial ovarian cancer?
### Response:
| A change in hMLH1 MET is a major molecular cause of acquired resistance to Pt-chemo in EOC. |
### Instruction:
Does beclin 1 gene inhibit tumor growth in colon cancer cell lines?
### Response:
| These results indicate that Beclin 1 can inhibit the growth of colorectal cancer cells. |
### Instruction:
Does diabetes alter expression of p53 and c-myc in different stages of oral oncogenesis?
### Response:
| It seems that diabetes contributed to increased accumulation of mutations in the p53 gene, contributing to increased proliferation of tumour cells during oral oncogenesis. Additionally, diabetes appeared to enhance c-myc expression only in the initial stages of oral oncogenesis. |
### Instruction:
Is day procedure intervention safe and complication free in higher risk patients undergoing transradial angioplasty and stenting . The discharge study?
### Response:
| Day case transradial percutaneous intervention with a 6-hr period of post procedure observation is a safe and feasible practice. The presence of higher-risk features should not be considered an absolute indication for overnight admission in patients considered clinically appropriate for discharge. |
### Instruction:
Does the genetic interaction between VKORC1 c1173t and calumenin a29809g modulate the anticoagulant response of acenocoumarol?
### Response:
| Our results suggest that CALU a29809g might be a new genetic factor involved in the pharmacogenetics of anticoagulant therapy, and confirm that specific genetic profiles defined by different polymorphisms will determine the initial response and dose required to achieve a stable and safe INR. |
### Instruction:
Does high expression reduce an antibody response after neonatal gene therapy with B domain-deleted human factor VIII in mice?
### Response:
| Injection of a high RV dose [10(10) transducing units (TU) kg(-1)] into newborn hemophilia A or C3H mice resulted in 61% and 13% of normal hFVIII antigen in plasma, respectively; most mice did not produce anti-hFVIII antibodies, and hemophilia A mice did not bleed. Furthermore, most mice with >20 ng mL(-1) of hFVIII in... |
### Instruction:
Is stromelysin-1 ( MMP-3 ) critical for intracranial bleeding after t-PA treatment of stroke in mice?
### Response:
| Our data with gene-deficient mice thus suggest that plasminogen and MMP-3 are relatively more important than MMP-9 for the increased ICB induced by t-PA treatment of ischemic stroke. |
### Instruction:
Does dysnatremia predict a delayed recovery in collapsed ultramarathon runners?
### Response:
| A slight majority of collapsed runners were normonatremic and spent significantly less time in the medical tent compared with hyper- and hyponatremic athletes. Initial rates of correction of hypernatremia were similar with intravenous and oral hypotonic fluid therapy. Clinicians should be advised that intravenous fluid... |
### Instruction:
Are balance and recovery from a perturbation impaired in people with functional ankle instability?
### Response:
| There are differences in balance and recovery between external controls and participants with both unilateral and bilateral FAI but not between the legs of participants with unilateral FAI. |
### Instruction:
Is interleukin-6 protein expression more important than interleukin-6 mRNA levels in assessing surgical invasiveness?
### Response:
| We conclude that IL-6 mRNA expression using RT-PCR to extract the total RNA from a patient's peripheral whole blood is more sensitive than protein levels but can be significantly affected by surgical procedures. The enzyme-linked immunosorbent assay data on IL-6 protein expression are more consistent and significant th... |
### Instruction:
Does [ A genome-wide screening for pathological myopia suggest a novel locus on chromosome 15q12 - 13 ]?
### Response:
| Our study indicates a novel myopia locus on 15q12 - 13. There are 94 known genes locate on this region, screening for sequence of candidate genes within this region will be helpful to find the mutant gene. This study also provides additional support for genetic heterogeneity of this disorder. |
### Instruction:
Does patient personality predict postoperative stay after colorectal cancer resection?
### Response:
| Personality as measured by EPQ predicts postoperative LOS in patients with colorectal cancer. Extroverts have a higher pain threshold and this may be part of the explanation. |
### Instruction:
Does atorvastatin lower portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase?
### Response:
| In cirrhotic rats, atorvastatin inhibits hepatic RhoA/Rho-kinase signaling and activates the NO/PKG-pathway. This lowers intrahepatic resistance, resulting in decreased portal pressure. Statins might represent a therapeutic option for portal hypertension in cirrhosis. |
### Instruction:
Do duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas?
### Response:
| Results suggest that duodenal follicular lymphomas have intermediate characteristics of MALT lymphomas and nodal follicular lymphomas. |
### Instruction:
Is aberrant methylation of IL-12Rbeta2 gene in lung adenocarcinoma cells associated with unfavorable prognosis?
### Response:
| We conclude that epigenetic silencing of IL-12Rbeta2 is a frequent event in lung cancers. Aberrant methylation of this gene seems to be a useful predictor of long-term outcome for adenocarcinoma of the lung. |
### Instruction:
Do bacillus Calmette-Guérin-pulsed dendritic cells stimulate natural killer T cells and gammadeltaT cells?
### Response:
| Sensitization of NKT cells and gammadeltaT cells by BCG-pulsed DCs might be one of the mechanisms of BCG immunotherapy. |
### Instruction:
Does hand-washing and diapering equipment reduce disease among children in out-of-home child care centers?
### Response:
| Diapering, hand-washing, and food-preparation equipment that is specifically designed to reduce the spread of infectious agents significantly reduced diarrheal illness among the children and absence as a result of illness among staff in out-of-home child care centers. |
### Instruction:
Does surface-etching enhance titanium implant osseointegration in newly formed ( rhBMP-2-induced ) and native bone?
### Response:
| Surface dual acid-etching of titanium implants has a positive effect on osseointegration in newly formed and native bone. Significant differences in bone density do not appear to influence this effect. |
### Instruction:
Is asymmetric dimethylarginine a marker of poor prognosis and coronary calcium in systemic lupus erythematosus?
### Response:
| Elevated ADMA is strongly associated with African American ethnicity, anti-dsDNA, low complement, and prednisone use, all markers of poor prognosis in SLE. It is negatively associated with hyperlipidemia, but positively associated with coronary calcium. Thus, it identifies a subset of SLE patients with normal lipid lev... |
### Instruction:
Does rosiglitazone decrease serum bone-specific alkaline phosphatase activity in postmenopausal diabetic women?
### Response:
| Rosiglitazone use is associated with reduced bone formation at earlier stages in postmenopausal diabetic women. The cytokine-lowering effects of rosiglitazone and lifestyle changes could reverse the early inhibitory effect of rosiglitazone therapy on bone formation. Further studies will clarify the long-term effects of... |
### Instruction:
Is two cycles of doxorubicin , bleomycin , vinblastine , and dacarbazine plus extended-field radiotherapy superior to radiotherapy alone in early favorable Hodgkin 's lymphoma : final results of the GHSG HD7 trial?
### Response:
| CMT consisting of two cycles of ABVD plus EF-RT is more effective than EF-RT alone. |
### Instruction:
Is collagen I induction by high glucose levels mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells?
### Response:
| We conclude that EGFR-PI3K-Akt signalling mediates high glucose-induced collagen I upregulation in mesangial cells and that this pathway is activated in diabetic glomeruli. Targeting its components may provide a new therapeutic approach to diabetic kidney disease. |
### Instruction:
Does low-dose aspirin use improve in vitro fertilization outcomes in poor responders?
### Response:
| Patients with a diagnosis of poor response who were taking a regimen of 81 of mg aspirin showed an increase in many IVF stimulation parameters and a decrease in fertilization rates. No improvement secondary to 81-mg aspirin intake was found in IVF outcome rates. |
### Instruction:
Does sTAT3 polymorphism predict interferon-alfa response in patients with metastatic renal cell carcinoma?
### Response:
| The present study suggested that the STAT3 polymorphism is a useful diagnostic marker to predict the response to IFN-alpha therapy in patients with MRCC. An efficient response marker for IFN-alpha needs to be utilized to establish individual optimal treatment strategies, even when newer drug therapies are used as first... |
### Instruction:
Does mild donor liver steatosis have no impact on hepatitis C virus fibrosis progression following liver transplantation?
### Response:
| Mild-moderate donor liver macrovesicular steatosis has no impact on HCV recurrence after liver transplantation for HCV-related cirrhosis. Cold ischaemia time and donor age increased the likelihood of HCV recurrence. |
### Instruction:
Does ionizing radiation induce degranulation of human mast cells and release of tryptase?
### Response:
| We propose that ionizing radiation leads to a degranulation of dermal mast cells, an event which is accompanied by the release of tryptase. |
### Instruction:
Does serum proteomic analysis identify a highly sensitive and specific discriminatory pattern in stage 1 breast cancer?
### Response:
| Mass spectrometry profiling of human serum generated a robust classifier composed of seven low-molecular-weight ions that yielded a highly sensitive and specific diagnostic procedure for the discrimination of women with stage 1 breast cancer compared with women without breast cancer in this research study set. |
### Instruction:
Does hsp90 mediate insulin-like growth factor 1 and interleukin-1beta signaling in an age-dependent manner in equine articular chondrocytes?
### Response:
| These results suggest that Hsp90 is involved in opposing signaling pathways of cartilage homeostasis, and that catabolic responses are more sensitive to Hsp90 inhibition than are anabolic responses. Further studies are needed to determine the role of Hsp90 inhibition in osteoarthritis in order to assess its potential a... |
### Instruction:
Does calcium signaling lead to mitochondrial depolarization in impact-induced chondrocyte death in equine articular cartilage explants?
### Response:
| Following a single impact load, calcium is released from the endoplasmic reticulum via the ryanodine receptor and is taken up by the mitochondria via the uniport transporter, causing mitochondrial depolarization and caspase 9 activation. In addition, calpains and CaMKII play important roles in causing mitochondrial dep... |
### Instruction:
Is lower heart rate variability associated with higher plasma concentrations of IL-6 in type 1 diabetes?
### Response:
| These findings suggest a link between low-grade inflammation and early alterations of CAN in type 1 diabetes and may be of importance in the pathogenesis of CAN and/or its clinical implications. |
### Instruction:
Is 4843delC of the BRCA1 gene a possible founder mutation in Southern Italy ( Sicily )?
### Response:
| We therefore conclude that 4843delC of the BRCA1 gene is a possible founder mutation in the Sicilian population. |
### Instruction:
Is restrictive filling pattern a powerful predictor of heart failure events postacute myocardial infarction and in established heart failure : a literature-based meta-analysis?
### Response:
| This literature-based meta-analysis confirms that RFP is a powerful predictor of HF hospitalization in patients with HF and especially the development of HF post-AMI. This is an important prognostic sign and should be incorporated into routine clinical practice. |
### Instruction:
Does treatment of obstructive sleep apnoea lead to enhanced pulmonary vascular nitric oxide release?
### Response:
| Successful treatment of obstructive sleep apnoeic episodes in sleep results in enhanced nitric oxide release by the pulmonary microvascular circulation. |
### Instruction:
Does silencing of caspase-8 and caspase-3 by RNA interference prevent vascular endothelial cell injury in mice with endotoxic shock?
### Response:
| Gene silencing of caspase-8 and caspase-3 with siRNAs provided profound protection against polymicrobial endotoxic shock. The prevention of vascular endothelial cell apoptosis appears to be, at least in part, responsible for their beneficial effects in endotoxic shock. |
### Instruction:
Does oxytocin attenuate amygdala responses to emotional faces regardless of valence?
### Response:
| Results suggest a modulatory role of oxytocin on amygdala responses to facial expressions irrespective of their valence. Reduction of amygdala activity to positive and negative stimuli might reflect reduced uncertainty about the predictive value of a social stimulus and thereby facilitates social approach behavior. |
### Instruction:
Does constant magnetic field of 50 mT affect weight gain and blood glucose level in BALB/c mice?
### Response:
| In the setting of this experiment, a 0.05-Tesla constant magnetic field had no impact on weight gain and blood glucose in BALB/c mice. It is possible that the reported effects in previous studies were partly due to sonic or thermal confounding effects caused by the electromagnets. |
### Instruction:
Are phencyclidine-induced cognitive deficits in mice improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711?
### Response:
| These findings suggest that repeated PCP administration significantly decreased the density of alpha7 nAChRs in the brain and that the alpha7 nAChR agonist SSR180711 could ameliorate cognitive deficits in mice after repeated administration of PCP. Therefore, alpha7 nAChR agonists including SSR180711 are potential thera... |
### Instruction:
Does a1166C polymorphism of the angiotensin AT1 receptor ( AT1R ) gene alter endothelial response to statin treatment?
### Response:
| The C allele of AT1R A1166C is associated with significantly lower endothelial response to statin treatment. |
### Instruction:
Is carotid artery intima media thickness inversely related to serum free thyroxine in euthyroid subjects?
### Response:
| In euthyroid subjects, IMT is associated with FT(4), after controlling for clinical factors, lipid levels and thyroid autoantibodies. These findings raise the possibility that, even within the euthyroid range, low normal thyroid function may adversely affect cardiovascular risk. |
### Instruction:
Is mannose-binding lectin a disease-modifying factor in North American patients with systemic lupus erythematosus?
### Response:
| A significantly increased prevalence of anti-Smith antibody was associated with the heterozygous genotypes A/B and A/C. Although MBL structural gene polymorphism was not a risk factor for SLE development in this study population, homozygosity of MBL variant alleles may be a weak disease-modifying factor, particularly f... |
### Instruction:
Do dietary omega-3-polyunsaturated fatty acids prevent the development of metastases of colon carcinoma in rat liver?
### Response:
| We could show that omega-3-fatty acids may decrease malignant metastatic tumor growth in the liver. |
### Instruction:
Is seropositivity for cytomegalovirus in patients with end-stage renal disease strongly associated with atherosclerotic disease?
### Response:
| CMV seropositivity is significantly associated with atherosclerotic disease in ESRD patients. Our data suggest that the risk for progressive atherosclerosis is specifically increased in patients with an inflammatory response to CMV. |
### Instruction:
Do two novel connexin32 mutations cause early onset X-linked Charcot-Marie-Tooth disease?
### Response:
| The two novel mutations in the connexin32 gene are more severe than the majority of previously described mutations possibly due to the severe structural change of the gap junction they encode. |
### Instruction:
Is faster rates of post-puberty kidney deterioration in males correlated with elevated oxidative stress in males vs females at early puberty?
### Response:
| Our data suggest that early puberty, with gender-related elevation in oxidative stress in males, is a key compromising factor on kidneys in males. |
### Instruction:
Do inflammatory multiple-sclerosis plaques generate characteristic metabolic profiles in cerebrospinal fluid?
### Response:
| CSF metabolic profiles suggest a close link between MS plaque activity in CIS patients on the one hand and organic-acid metabolism on the other. Our detection of increased BHIB levels points to a hitherto unsuspected role for this compound in MS with active plaques, and serves as a basis for further investigation. The ... |
### Instruction:
Do prostatic stromal cells derived from benign prostatic hyperplasia specimens possess stem cell like property?
### Response:
| Our study on primary stromal cells from BPH patients have yielded many interesting findings that these prostate stroma cells possess: (1) mesenchymal stem cell (MSC) markers; (2) strong proliferative potential; and (3) ability to differentiate or transdifferentiate to myogenic, adipogenic, and osteogenic lineages. Thes... |
### Instruction:
Do functional polymorphisms of the GSTT-1 gene predict the severity of acute pancreatitis in the United States?
### Response:
| Functional GSTT-1 phenotypes do not correlate with susceptibility to AP or severity of AP in our patient population. |
### Instruction:
Does tumor size significantly correlate with postoperative liver metastases and COX-2 expression in patients with resectable pancreatic cancer?
### Response:
| There were three significant prognostic factors in patients with resectable pancreatic cancer who had local therapy. Patients who have a large tumor require particularly careful follow-up for postoperative liver metastases. |
### Instruction:
Does rosiglitazone reduce office and diastolic ambulatory blood pressure following 1-year treatment in non-diabetic subjects with insulin resistance?
### Response:
| RSG treatment for 1 year was associated with a small but significant decrease in diastolic 24-h ambulatory diastolic BP, and both systolic and diastolic office BPs in non-diabetic people with insulin resistance. |
### Instruction:
Does sensitivity of hepatitis C virus to cyclosporine A depend on nonstructural proteins NS5A and NS5B?
### Response:
| Preexisting sequence variation could alter the effect of cyclosporine on HCV in vivo. |
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