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### Instruction:
Does type-D personality but not depression predict severity of anxiety in heart failure patients at 1-year follow-up?
### Response:
| Type-D personality, but not depressive symptoms predicted 1-year clinically significant anxiety. The type-D scale could be used to identify CHF patients at high risk of anxiety, as these patients may be at an increased risk of adverse prognosis and impaired quality of life. |
### Instruction:
Is improvement in central arterial pressure waveform during hemodialysis related to a reduction in asymmetric dimethylarginine ( ADMA ) levels?
### Response:
| The reduction in ADMA level seen after HD was associated with improvement in the central arterial pressure waveform, suggesting involvement of nitric oxide in the regulation of arterial stiffness in HD patients. |
### Instruction:
Does gene expression profiling identify C/EBPdelta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation?
### Response:
| Our results endorse the usefulness of gene expression profiling in identifying novel mediators of DIC by showing that C/EBPdelta regulates specific pathologic features of this endotoxin-induced syndrome. |
### Instruction:
Does spectral karyotyping detect chromosome damage in bronchial cells of smokers and patients with cancer?
### Response:
| Clonal and single-cell chromosomal abnormalities are frequent in benign bronchial epithelium during lung carcinogenesis, indicating that chromosomal missegregation and other chromosomal rearrangements occur before overt malignancy. |
### Instruction:
Do epigallocatechin-3-gallate and bicalutamide cause growth arrest and apoptosis in NRP-152 and NRP-154 prostate epithelial cells?
### Response:
| This study demonstrates the potential use of EGCG and other antioxidants as therapeutic candidates for prostate cancer. |
### Instruction:
Does aryl-hydrocarbon receptor activation regulate constitutive androstane receptor levels in murine and human liver?
### Response:
| This study identifies a mode of up-regulating CAR and potentially expands the role of AhR in drug metabolism. This study also demonstrates in vivo up-regulation of CAR through chemical exposure. |
### Instruction:
Are plasma dimethylarginine levels in chronic hemodialysis patients independent of the type of dialyzer applied?
### Response:
| Despite an intradialytic decrease in dimethylarginines, no changes occurred after 4 weeks of HD with either membrane. Furthermore, the variability of AMDA, SDMA and L-arginine levels was far more dependent on patient-related factors than on the type of dialyzer applied. |
### Instruction:
Does luminal substrate `` brake '' on mucosal maltase-glucoamylase activity regulate total rate of starch digestion to glucose?
### Response:
| MGAM primes and SI activity sustains and constrains prandial alpha-glucogenesis from starch oligomers at approximately 5% of the uninhibited rate. This coupled mucosal mechanism may contribute to highly efficient glucogenesis from low-starch diets and play a role in meeting the high requirement for glucose during child... |
### Instruction:
Does c-Jun N-terminal kinase ( JNK ) cooperate with Gsk3beta to regulate Dishevelled-mediated microtubule stability?
### Response:
| We demonstrate a novel role for JNK in Wnt-mediated MT stability. Wnt-Dvl pathway increases MT stability through a transcription independent mechanism that requires the concomitant inhibition of Gsk3beta and activation of JNK. These studies demonstrate that Wnts can simultaneously activate different signalling pathways... |
### Instruction:
Is 13-Oxo-ODE an endogenous ligand for PPARgamma in human colonic epithelial cells?
### Response:
| High amounts of 13-Oxo-ODE can be induced in CECs by stimulation of linoleic acid metabolism. 13-Oxo-ODE binds to PPARgamma and has anti-inflammatory effects. 13-HODE dehydrogenase might be a therapeutic target in IBD. |
### Instruction:
Is hIF-1 alpha a regulator of galectin-3 expression in the intervertebral disc?
### Response:
| Together, these studies showed that gal-3 is a HIF-1-regulated lectin that plays an important role in nucleus pulposus cell survival. |
### Instruction:
Is receptor for advanced glycation end products ( RAGE ) important in the prediction of recurrence in human oral squamous cell carcinoma?
### Response:
| RAGE is a relevant factor in predicting disease recurrence and patients' prognosis in OSCC. |
### Instruction:
Do attention deficit hyperactivity disorder symptoms predict nicotine dependence and progression to regular smoking from adolescence to young adulthood?
### Response:
| These results have important implications for the development of prevention and treatment modalities. |
### Instruction:
Is hospitalization of patients with eating disorders on adolescent medical units threatened by current reimbursement systems?
### Response:
| Other than admission weight, there were no significant clinical differences between AN and EDNOS participants. 95% responded favorably to interdisciplinary treatment. Length of stay could be reduced with earlier admission of malnourished patients. In spite of effective services, reimbursement by insurance companies rem... |
### Instruction:
Does sanguinarine inhibit VEGF-induced angiogenesis in a fibrin gel matrix?
### Response:
| SA appear to be an antiangiogenic natural product by directly suppressing the proliferative effect of VEGF on endothelial cell line: this effect could be mediated by blocking the VEGF-induced Akt activation. |
### Instruction:
Are cognitive complaints in the early phase after stroke indicative of cognitive impairment?
### Response:
| Cognitive complaints hindering daily life are frequently reported in the early weeks after stroke but are no indication for impaired cognitive performance. To identify patients with cognitive impairment, neuropsychological assessment is essential. |
### Instruction:
Does severity of obstructive airways disease by age 2 years predict asthma at 10 years of age?
### Response:
| Using a simple scoring system, a high severity score of OAD by 2 years of age is a strong risk factor for, and may predict, current asthma at 10 years of age. |
### Instruction:
Are dysbindin ( DTNBP1 ) and the biogenesis of lysosome-related organelles complex 1 ( BLOC-1 ) : main and epistatic gene effects potential contributors to schizophrenia susceptibility?
### Response:
| Together these data provide evidence for the involvement of the BLOC-1 protein complex in SZ pathogenesis. |
### Instruction:
Is maximal bladder capacity a positive predictor of response to desmopressin treatment in patients with MS and nocturia?
### Response:
| Our results suggest that desmopressin is effective in the symptomatic management of nocturia in patients with MS and neurogenic detrusor overactivity. Maximal bladder capacity is a valuable predictor of response to desmopressin. |
### Instruction:
Does ga-As ( 808 nm ) laser irradiation enhance ATP production in human neuronal cells in culture?
### Response:
| Laser application to NHNP cells significantly increases ATP production in these cells. These findings may explain the beneficial effects of low-level laser therapy (LLLT) in stroked rats. Tissue culture of NHNP cells might offer a good model to study the mechanisms associated with promotion of ATP production in the ner... |
### Instruction:
Are c-reactive protein and low albumin predictors of morbidity and cardiovascular events in chronic kidney disease ( CKD ) 3-5 patients?
### Response:
| Our results show that CRP and low albumin, markers of inflammation, predict cardiovascular events and morbidity in CKD 3-5 patients before initiation of chronic hemodialysis. |
### Instruction:
Does human serum paraoxonase concentration predict cardiovascular mortality in hemodialysis patients?
### Response:
| These data suggest that low PON 1 concentration may be an independent predictor of cardiovascular mortality in maintenance HD patients. |
### Instruction:
Does hysterectomy lead to fast improvement of haematological and immunological parameters in bitches with pyometra?
### Response:
| Application of immunostimulating therapy is not necessary to manage changes in blood cell counts and suppression of lymphocyte activity in bitches with pyometra. Removal of the infected uterus, being the source of infection, leads to improvement. |
### Instruction:
Does [ Chinese herbal medicine PC-SPES II induce the apoptosis of androgen-independent prostate carcinoma cell line PC-3 ]?
### Response:
| The Chinese herbal mixture PCSPES II can induce the apoptosis of PC-3. Its mechanism may lie in the up-regulation of Bax expression and down-regulation of Bcl-2 and Bcl-xL expressions, which induce the activated fragments of caspase-3 by mitochondria. |
### Instruction:
Does pinacidil reduce neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways?
### Response:
| K(ATP) opener can significantly decrease the neuronal apoptosis and the expressions of caspase-3, caspase-8 and caspase-9 mRNAs following cerebral ischemia-reperfusion. The neuronal apoptosis may be decreased by the inhibition of both mitochondrial and death-receptor signal pathways. |
### Instruction:
Is adiponectin a novel humoral vasodilator?
### Response:
| Adiponectin is a novel humoral vasodilator that relaxes aortic and mesenteric rings by opening K(v) channels. Similar to the rat, perivascular adipose tissue of the mouse harbors an ADRF, which is malfunctional in NZO mice and is not adiponectin. |
### Instruction:
Is long-term fish intake associated with better lipid profile , arterial blood pressure , and blood glucose levels in elderly people from Mediterranean islands ( MEDIS epidemiological study )?
### Response:
| The results indicate that long-term fish intake is associated with reduced levels of the most common cardiovascular disease risk markers in a cohort of elderly people. |
### Instruction:
Do evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests?
### Response:
| The chloroform fraction of the total ethanolic extract of Convolvulus pluricaulis elicited a significant antidepressant-like effect in mice by interaction with the adrenergic, dopaminergic, and serotonergic systems. |
### Instruction:
Are age-adjusted Plasmodium falciparum antibody levels in school-aged children a stable marker of microgeographical variations in exposure to Plasmodium infection?
### Response:
| Age-adjusted Pfs-IgG3 levels of school-aged children are stable and when mapped can provide a tool sensitive enough to detect microgeographical variations in malaria exposure, that would be useful for studying the aetiology of morbidities associated with long-term exposure and co-infections. |
### Instruction:
Is kIT required for hepatic function during mouse post-natal development?
### Response:
| This is a first report involving KIT in the control of lipid metabolism in neonates and opening new perspectives for understanding juvenile steatosis. Moreover, it reinforces the role of Kit during development of the liver and underscores the caution that should be exerted in using KIT inhibitors during anti-cancer tre... |
### Instruction:
Does pyruvate enhance neurological recovery following cardiopulmonary arrest and resuscitation?
### Response:
| Intravenous pyruvate therapy during cardiopulmonary resuscitation prevents initial oxidative stress and neuronal injury and enhances neurological recovery from cardiac arrest. |
### Instruction:
Is plaque rupture in the carotid artery localized at the high shear stress region : a case report?
### Response:
| In this serial MRI study, we found plaque ulceration at the high WSS location of a protruding plaque in the carotid artery. Our data suggest that high WSS influences plaque vulnerability and therefore may become a potential parameter for predicting future events. |
### Instruction:
Are diffusion-weighted imaging-negative patients with transient ischemic attack at risk of recurrent transient events?
### Response:
| The absence of a diffusion-weighted imaging lesion on the baseline scan predicts recurrent transient events rather than stroke. |
### Instruction:
Does crystal structure of vaccinia virus uracil-DNA glycosylase reveal dimeric assembly?
### Response:
| The crystal structures reveal several distinctive features of vvUDG. The new structural features may have evolved for adopting novel functions in the replication machinery of poxviruses. The mode of interaction between the subunits in the dimers suggests a possible model for binding to its partner and the nature of the... |
### Instruction:
Does a high-accuracy consensus map of yeast protein complexes reveal modular nature of gene essentiality?
### Response:
| We demonstrate that our scoring method can generate an integrated high-confidence subset of observed matrix-model interactions, which we subsequently used to derive an accurate map of yeast complexes. Our results indicate that essentiality is a product of the protein complex rather than the individual protein, and that... |
### Instruction:
Does estrogen increase glucose-induced insulin secretion from mouse pancreatic islets cultured in a prolonged high glucose condition?
### Response:
| These results indicated a direct effect of estrogen on improving insulin secretion from mouse pancreatic islets that has been impaired by prolonged exposure to high glucose. |
### Instruction:
Does subfoveal fluid resolve slowly after pars plana vitrectomy for tractional retinal detachment secondary to proliferative diabetic retinopathy?
### Response:
| Persistent subfoveal fluid may take several months to resolve in patients undergoing PPV to repair TRD secondary to PDR and account for delayed visual recovery. OCT is an important tool in the follow-up of patients undergoing vitrectomy for TRD. |
### Instruction:
Does s-nitrosoglutathione prevent interphotoreceptor retinoid-binding protein ( IRBP ( 161-180 ) ) -induced experimental autoimmune uveitis?
### Response:
| The oral administration of GSNO significantly suppressed the levels of inflammatory mediators in the retinas of EAU mice. This suppression was associated with the maintenance of normal retinal histology and function. These results clearly demonstrated the therapeutic potential of GSNO in EAU, and provide new insights f... |
### Instruction:
Does l-carnitine protect human retinal pigment epithelial cells from oxidative damage?
### Response:
| LC is capable of protecting the RPE cells from H2O2-induced oxidative damage, implying that micronutrients can have a positive effect and can play an important role in the treatment of oxidation-induced ocular disorders. Further studies are needed to understand the mechanism of LC-induced protection to the RPE cells. |
### Instruction:
Does rANKL inhibition through osteoprotegerin block bone loss in experimental periodontitis?
### Response:
| Systemic delivery of OPG-Fc inhibits alveolar bone resorption in experimental periodontitis, suggesting that RANKL inhibition may represent an important therapeutic strategy for the prevention of progressive alveolar bone loss. |
### Instruction:
Does use of small-bore silastic drain in general thoracic surgery?
### Response:
| We considered that soft, small-bore silastic drains were just as effective as traditional DL tubes, but caused less pain especially in VATS cases. |
### Instruction:
Does aTM activation accompany histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke?
### Response:
| These data implicate ATM as the PIKK that phosphorylates H2AX in response to DNA damage caused by CS. Based on current understanding of ATM activation, expression and localization, these data would suggest that, in addition to inducing potentially carcinogenic DSB lesions, CS may also trigger other types of DNA lesions... |
### Instruction:
Are serum myeloperoxidase levels associated with the future risk of coronary artery disease in apparently healthy individuals : the EPIC-Norfolk Prospective Population Study?
### Response:
| Elevated MPO levels predict future risk of CAD in apparently healthy individuals. This study suggests that inflammatory activation precedes the onset of overt CAD by many years. |
### Instruction:
Is a variant epidermal growth factor receptor protein similarly expressed in benign hyperplastic and carcinomatous prostatic tissues in black and white men?
### Response:
| These results demonstrate that EGFRvIII immunoreactivity in prostatic tumours in black men is similar to that in white men. Anti-cancer treatments directed at the EGFRvIII should be equally effective in men from both subpopulations. |
### Instruction:
Are elevated vascular endothelial growth factor pretreatment levels correlated with the tumor burden in Hodgkin lymphoma and continue to be elevated in prolonged complete remission?
### Response:
| Pathologic angiogenesis is an activated pathway in Hodgkin lymphoma and participates in Hodgkin lymphoma progression. This has been shown by an elevated VEGF level in patients: before first treatment, with greater tumor burden, and with a higher number of involved areas. Furthermore, VEGF continues to be elevated in pa... |
### Instruction:
Does activation of GABA ( B ) receptors reverse spontaneous gating deficits in juvenile DBA/2J mice?
### Response:
| Our data highlight GABA(B) receptors as an important substrate for sensorimotor gating control in DBA/2J mice and encourage further investigations on the role of GABA(B) receptors in sensorimotor gating, as well as in the pathophysiology of psychotic disturbances. |
### Instruction:
Is acute psychotic stress associated with decreased adiponectin serum levels?
### Response:
| These data suggest a link between acute psychotic stress reaction and decreased serum adiponectin levels. Further studies are recommended to determine the strength of this association. |
### Instruction:
Do treatment for co-occurring mental and substance use disorders in five state Medicaid programs?
### Response:
| Heavy inpatient and emergency department use by Medicaid beneficiaries with co-occurring substance use disorders is a consistent cross-state problem. Co-occurring disorders may decrease the likelihood of community-based treatment for those with less severe mental disorders and for those with severe mental illness, sugg... |
### Instruction:
Does [ HLA B27 seem to promote graft failure following penetrating keratoplasties for herpetic corneal scars ]?
### Response:
| This retrospective analysis suggests that the HLA B27 phenotype promotes recurrence of herpetic eye disease following penetrating keratoplasty. HLA B27-positive patients should be closely monitored, and the indications for prophylactic antiviral therapy should be viewed liberally in this group. |
### Instruction:
Does aldosterone induce CTGF in mesangial cells by activation of the glucocorticoid receptor?
### Response:
| CTGF is a functional target of aldosterone in mesangial cells, but aldosterone-induced CTGF gene expression is not directly mediated by the mineralocorticoid receptor. |
### Instruction:
Does physiological hyperinsulinemia have no detectable effect on access of macromolecules to insulin-sensitive tissues in healthy humans?
### Response:
| Our data suggest that in contrast to studies performed in dogs, insulin at physiological concentrations does not augment recruitment of insulin-sensitive tissues in healthy humans. |
### Instruction:
Are variants of the transcription factor 7-like 2 ( TCF7L2 ) gene associated with type 2 diabetes in an African-American population enriched for nephropathy?
### Response:
| This study indicates that variants in the TCF7L2 gene significantly contribute to diabetes susceptibility in African-American populations. |
### Instruction:
Is plasma lyso-phosphatidylcholine concentration decreased in cancer patients with weight loss and activated inflammatory status?
### Response:
| In conclusion, LPC concentrations were decreased in cancer patients. LPC plasma concentrations correlated with weight loss and inflammatory parameters and, therefore, might be a general indicator of severity of malignant disease. |
### Instruction:
Is characteristic Ber-EP4 and EMA expression in sebaceoma immunohistochemically distinct from basal cell carcinoma?
### Response:
| The use of Ber-EP4 in combination with EMA, both widely used immunomarkers in histopathology, is a helpful aid in distinguishing sebaceoma from nodular BCC. |
### Instruction:
Do human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone?
### Response:
| Adrenocorticotrophic hormone stimulation increases adrenal vein but not peripheral vein vitamin C concentrations. These data are the first in humans showing that hormone-regulated vitamin secretion occurs and that adrenal vitamin C paracrine secretion is part of the stress response. Tight control of peripheral vitamin ... |
### Instruction:
Does extract of Salacia oblonga lower acute glycemia in patients with type 2 diabetes?
### Response:
| The extract of Salacia oblonga lowers acute glycemia and insulinemia in persons with type 2 diabetes after a high-carbohydrate meal. The results from this study suggest that Salacia may be beneficial to this population for postprandial glucose control. |
### Instruction:
Do lateral motor column axons execute a ternary trajectory choice between limb and body tissues?
### Response:
| We have found that medial LMC neurons innervate both ventral flank and limb targets. While normally only a subset of medial LMC axons innervate the flank, all are capable of doing so. Furthermore, LMC axons execute a ternary, rather than binary, choice at the base of the limb between ventral flank, ventral limb and dor... |
### Instruction:
Does activation of the mGlu7 receptor elicit antidepressant-like effects in mice?
### Response:
| These results strongly suggest that activation of the mGlu7 receptor elicits antidepressant-like effects. |
### Instruction:
Do relationship between hip strength and frontal plane posture of the knee during a forward lunge?
### Response:
| The findings suggest that in healthy subjects hip muscle strength is not correlated to the amount of valgus/varus movement of the knee during a forward lunge. This suggests that other factors (eg, proprioception, core hip stability) might be more important in controlling knee movement during this tennis-specific moveme... |
### Instruction:
Is medical therapy for diabetes associated with increased use of lower endoscopy?
### Response:
| Diabetic patients receiving medications are more likely to undergo lower endoscopy than those on diet control alone, particularly in the first year after initiating a new medication class and if taking metformin. |
### Instruction:
Is c1D a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome?
### Response:
| Our results demonstrate that the recently identified exosome-associated protein C1D is a major autoantigen in patients with the PM-scleroderma overlap syndrome and suggest that the use of recombinant C1D as an autoantibody target may aid in diagnosis of the PM-scleroderma overlap syndrome. |
### Instruction:
Do temporomandibular disorders correlate with detectable alterations in body posture?
### Response:
| This study failed to show detectable alterations in body posture in TMD patients. |
### Instruction:
Does an intramembrane glutamic acid govern peripherin/rds function for photoreceptor disk morphogenesis?
### Response:
| E276 plays a critical role in P/rds support of photoreceptor OS structure. This finding provides a molecular rationale for asymmetry in P/rds and rom-1 function and for rom-1 regulation of P/rds activity. These findings also suggest that ionizable intramembrane residues may serve regulatory roles for tetraspanin protei... |
### Instruction:
Do secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival?
### Response:
| These results show that Sulf1 and Sulf2 play overlapping yet critical roles in mouse development and are redundant and essential for neonatal survival. |
### Instruction:
Does recruitment of Polo kinase to the spindle midzone during cytokinesis require the Feo/Klp3A complex?
### Response:
| Our results reveal that the Feo/Klp3A complex is necessary for Polo recruitment to the spindle midzone. A similar finding has also been recently reported in mammalian cells [1], suggesting that this basic mechanism has been conserved during evolution, albeit with some differences. Finally, since cleavage furrow formati... |
### Instruction:
Does expression profiling of Dexamethasone-treated primary chondrocytes identify targets of glucocorticoid signalling in endochondral bone development?
### Response:
| Together, these results provide insight into the mechanisms and major molecular classes functioning downstream of DEX in primary chondrocytes. In addition, comparison of our data with microarray studies of DEX treatment in other cell types demonstrated that the majority of DEX effects are tissue-specific. This study pr... |
### Instruction:
Do histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans?
### Response:
| In humans--as in rodents--biomaterial-mediated inflammatory responses involve at least two crucial events: histamine-mediated phagocyte recruitment and phagocyte accumulation on implant surfaces engendered by spontaneously adsorbed host fibrinogen. Based on these results, we conclude that reducing fibrinogen:surface in... |
### Instruction:
Is functional -1562 C-to-T polymorphism in matrix metalloproteinase-9 ( MMP-9 ) promoter associated with the risk for oral squamous cell carcinoma in younger male areca users?
### Response:
| Aberrant MMP-9 expression is closely related to tumor invasiveness and the prognosis of head and neck cancers. However, functional MMP-9 -1562 C>T polymorphism is associated with OSCC risk only in younger areca chewers. The impact of aging or areca-related effect on this functional polymorphism should be elucidated. |
### Instruction:
Is dRD4 VNTR polymorphism associated with transient fMRI-BOLD responses to smoking cues?
### Response:
| These brain imaging results suggest that DRD4 VNTR polymorphism is related to transient brain responses to smoking cues in regions subserving executive and somatosensory processes. |
### Instruction:
Do extra-embryonic endoderm cells derived from ES cells induced by GATA factors acquire the character of XEN cells?
### Response:
| We show here that Gata-induced extra-embryonic endoderm cells derived from ES cells mimic the character of XEN cells. These findings indicate that Gata transcription factors are sufficient for the derivation and propagation of XEN-like extra-embryonic endoderm cells from ES cells. |
### Instruction:
Do antibodies elicited in adults by a primary Plasmodium falciparum blood-stage infection recognize different epitopes compared with immune individuals?
### Response:
| Adults infected with P. falciparum for the first time, develop relatively short-lived immune responses that, in the case of MSP119, are functional. Antibodies to the polymorphic antigens studied were particularly directed to allelic family specific, non-repetitive and conserved determinants and were not IgG subclass sk... |
### Instruction:
Does diclofenac prevent an early event of macular thickening after cataract surgery in patients with diabetes?
### Response:
| Postoperative macular thickening following cataract surgery in patients with non- or mild nonproliferative-diabetic retinopathy cannot be fully suppressed by either topical diclofenac or betamethasone. Nonetheless, diclofenac protected against an early event of postoperative CME and also a decrease of IOP. |
### Instruction:
Is physical activity associated with a low prevalence of musculoskeletal disorders in the Royal Norwegian Navy : a cross sectional study?
### Response:
| The one-year prevalence of musculoskeletal disorders among workers in the Royal Norwegian Navy was rather low. A physically active lifestyle both at work and at leisure was associated with fewer musculoskeletal disorders among personnel in the Royal Norwegian Navy. Prospective studies are necessary to confirm the cause... |
### Instruction:
Does pyrrolidine dithiocarbamate prevent 60 minutes of warm mesenteric ischemia/reperfusion injury in rats?
### Response:
| This study showed that PDTC treatment significantly prevented the reperfusion injury caused by superior mesenteric I/R. Further clinical studies are needed to clarify whether PDTC may be a useful therapeutic agent to use in particular operations where the reperfusion injury occurs. |
### Instruction:
Do estimating the expense of a mandatory home-and community-based personal assistance services benefit under Medicaid?
### Response:
| Creating a mandatory PAS benefit for those with an institutional level of need is a fiscally achievable policy strategy to redress the imbalance between institutional and community-based services under Medicaid. |
### Instruction:
Do [ Middle term results of I metatarsal `` Scarf '' osteotomy ]?
### Response:
| Based on results, "Scarf" osteotomy permits an adequate deformity correction of first metatarsus varus also with intermetatarsal angle between first and second metatarsal superior to 20 degrees degree. |
### Instruction:
Do brain injury severity and autonomic dysregulation accurately predict heterotopic ossification in patients with traumatic brain injury?
### Response:
| The occurrence of autonomic dysregulation may predict the chance of developing heterotopic ossification in patients with severe head injury. |
### Instruction:
Does frailty modify effectiveness of psychosocial intervention in recovery from stroke?
### Response:
| While there is evidence that the treatment benefited healthier subgroups, results also show evidence that the treatment was not effective, and possibly harmful, in frail subgroups. |
### Instruction:
Does ski promote tumor growth through abrogation of transforming growth factor-beta signaling in pancreatic cancer?
### Response:
| Inhibition of Ski through RNA interference restored TGF-beta signaling and growth inhibition in vitro, and decreased tumor growth in vivo. |
### Instruction:
Is chemotherapy associated with improved survival in adult patients with primary extremity synovial sarcoma?
### Response:
| Ifosfamide-based chemotherapy was associated with an improved DSS in adult patients with high-risk, primary, extremity, synovial sarcoma and should be considered in the treatment of such patients. |
### Instruction:
Does mutation of the gap junction protein alpha 8 ( GJA8 ) gene cause autosomal recessive cataract?
### Response:
| These results confirm involvement of GJA8 in autosomal recessive cataract. |
### Instruction:
Does stoichiometric alteration of PMP22 protein determine the phenotype of hereditary neuropathy with liability to pressure palsies?
### Response:
| Taken together, these results confirm that the phenotypic expression is identical in patients with Leu7fs mutation and patients with HNPP caused by chromosome 17p11.2 deletion. They also demonstrate that reduction of PMP22 is sufficient to cause the full HNPP phenotype. |
### Instruction:
Does propranolol cause a paradoxical enhancement of cardiomyocyte foetal gene response to hypertrophic stimuli?
### Response:
| Propranolol enhances expression of the hypertrophy-associated foetal genes mainly via the beta(1)-adrenoceptor blockade. Our results also suggest that, in pressure-overloaded hearts, cardiomyocyte growth and foetal gene expression occur as independent processes. |
### Instruction:
Does the snake venom metalloproteinase BaP1 induce joint hypernociception through TNF-alpha and PGE2-dependent mechanisms?
### Response:
| This is the first demonstration that a metalloproteinase promotes joint hypernociception. This effect involves local release of PGE(2) and TNF-alpha. BaP1-induced increase in PGE(2) is associated to increased COX-2 expression in macrophages. Blocking PGE(2) or TNF-alpha inhibits BaP1-induced hypernociception. In additi... |
### Instruction:
Do [ Chemotactic effects of burn rat serum on mesenchymal stem cells derived from different sources ]?
### Response:
| MSC can be isolated and cultured from bone marrow and peripheral blood of burn rat, but not from peripheral blood of normal rat. Burn rat serum has a stronger chemotactic effect on MSC. Moreover, the migration ability of MSC derived from burn rat is stronger than that of MSC derived from normal rat. |
### Instruction:
Does children plus all nonautomobile motorized vehicles ( not just all-terrain vehicles ) equal injuries?
### Response:
| Although most public health and legislative attention to date has been focused on all-terrain vehicles, parents, children, and public officials should be educated about the injury risk that all types of nonautomobile motorized vehicles pose to children. |
### Instruction:
Does the cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhance doxorubicin-DNA adduct mediated cytotoxicity?
### Response:
| Sobuzoxane has also been shown to decrease the normally dose limiting cardiotoxicity commonly exhibited with clinical use of doxorubicin. The potential combination of doxorubicin and sobuzoxane in cancer chemotherapy has two advantages. First, the mechanism of doxorubicin toxicity is shifted away from topoisomerase II ... |
### Instruction:
Are endothelial microparticle levels similar in acute ischemic stroke and stroke mimics due to activation and not apoptosis/necrosis?
### Response:
| EMP levels were similar in patients with AIS and stroke mimic patients. The PECAM-1/E-selectin ratio demonstrated that EMPs were generated via activation and not apoptosis/necrosis. This suggests that EMPs may not be a good marker for AIS, given the inability to discriminate between stroke mimics and AIS. |
### Instruction:
Does pioglitazone attenuate fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells?
### Response:
| Pioglitazone attenuated fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells. TZDs might be used as a mean for maintaining beta-cell survival and preserving capacity of insulin secretion in patients with diabetes mellitus. |
### Instruction:
Do comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans?
### Response:
| Our findings provide tangible hints for elucidating the genetic basis of important phenotypic differences between these two streptomycetes. Importantly, absence of certain genes in S. lividans identified here could potentially explain the relative ease of DNA transformations and the conditional lack of actinorhodin syn... |
### Instruction:
Does the Finnish lapphund retinal atrophy locus map to the centromeric region of CFA9?
### Response:
| The locus for progressive rod-cone degeneration is known to be close to the GALK1 locus, on the telomeric region of chromosome 9, where the retinal atrophy locus of the Finnish lapphund has been mapped. This suggests that the disease in this breed, as well as in the Swedish lapphund, may correspond to progressive rod-c... |
### Instruction:
Does regeneration in pig livers by compensatory hyperplasia induce high levels of telomerase activity?
### Response:
| Our data demonstrate telomerase activation in liver regeneration by compensatory hyperplasia in a large animal model with telomere biology comparable to humans. Telomerase activation may constitute a mechanism to protect proliferating liver cells against telomere shortening and oxidative stress. |
### Instruction:
Is anesthetic duration of lidocaine with 10 % dextran comparable to lidocaine with 1:160 000 epinephrine after intraosseous injection in the rabbit?
### Response:
| Ten percent dextran potentiates local anesthetic effects of 2% lidocaine in intraosseous injection. The potency of 10% dextran is comparable to 1:160 000 epinephrine. |
### Instruction:
Does dilinoleoyl-phosphatidic acid mediate reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle?
### Response:
| These data indicate that linoleate-derived phosphatidic acid is a novel lipid species that contributes independently of protein kinase C to IRS-1 signalling defects in muscle cells in response to lipid oversupply. |
### Instruction:
Does endoplasmic reticulum stress cause the activation of sterol regulatory element binding protein-2?
### Response:
| These results imply that ER stress-induced SREBP-2 activation occurs through the conventional pathway that normally regulates SREBP in accordance with intracellular sterol concentration. |
### Instruction:
Is lower cardiac output associated with greater white matter hyperintensities in older adults with cardiovascular disease?
### Response:
| These preliminary data suggest that systemic blood flow, measured according to cardiac output, is inversely associated with WMHs adjacent to the subcortical nuclei. Cerebrovascular degeneration and the chronicity of hypoperfusion may exacerbate the susceptibility of white matter integrity to alterations in blood flow i... |
### Instruction:
Does bleomycin induce caveolin-1 and -2 expression in epithelial lung cancer A549 cells?
### Response:
| The early up-regulation of caveolin-1 and -2 following bleomycin exposure is a rather apoptosis-independent event related to other unknown mechanisms of bleomycin-mediated cell injury. |
### Instruction:
Is intermittent preventive treatment with sulphadoxine-pyrimethamine effective in preventing maternal and placental malaria in Ibadan , south-western Nigeria?
### Response:
| IPT-SP is effective in preventing maternal and placental malaria as well as improving pregnancy outcomes among parturient women in Ibadan, Nigeria. The implementation of the recently adopted IPT-SP strategy should be pursued with vigour as it holds great promise for reducing the burden of malaria in pregnancy in Nigeri... |
### Instruction:
Is axonal loss progressive and partly dissociated from lesion load in early multiple sclerosis?
### Response:
| Our data reveal an early and progressive axonal damage in relapsing-remitting multiple sclerosis. Axonal loss and T2 lesion volume seem to be at least partly dissociated processes in early stages of the disease. |
### Instruction:
Does [ Studies on flavonoids from stem and leaves of Calophyllum inophyllum ]?
### Response:
| Compounds 8 and 9 were isolated from the genus Calophyllum and compounds 1, 2, 4-6 were isolated from this plant for the first time. |
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