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### Instruction:
Are increased levels of neurotrophins specific for chronic migraine : evidence from primary fibromyalgia syndrome?
### Response:
| This article presents findings of higher NGF and BDNF levels correlated to increased glutamate levels in the CSF of both chronic migraine and fibromyalgia patients. This opens new insights into the pathogenic mechanisms of chronic pain and offers clinicians new therapeutic perspectives targeting the above mechanisms in... |
### Instruction:
Do igG fc receptors provide an alternative infection route for murine gamma-herpesvirus-68?
### Response:
| IgG Fc receptors limit the neutralization of gamma-herpesviruses such as MHV-68. |
### Instruction:
Does hexose-6-phosphate dehydrogenase modulate 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids?
### Response:
| Our results from experiments determining the steady state concentrations of glucocorticoids or 7-oxygenated neurosteroids suggested that the equilibrium between cortisone and cortisol and between 7-keto- and 7-hydroxy-neurosteroids is regulated by 11beta-HSD1 and greatly depends on the coexpression with H6PDH. Thus, th... |
### Instruction:
Do therapeutic concentrations of raloxifene augment nitric oxide-dependent coronary artery dilatation in vitro?
### Response:
| Raloxifene in therapeutically relevant concentrations augmented endothelial function in porcine coronary arteries in vitro through ICI 182,780-sensitive mechanisms that were associated with increased phosphorylation of eNOS but independent of changes in endothelial cell [Ca(2+)](i). |
### Instruction:
Do women who experience detrusor overactive at lower bladder volumes report greater bother?
### Response:
| Women who experience DOI at lower volumes during urodynamics report greater bother and QOL impact from incontinence than women who leak at higher volumes. |
### Instruction:
Does systematic review identify number of strategies important for retaining study participants?
### Response:
| Available evidence suggests that investigators should consider using a number of retention strategies across several themes to maximize the retention of participants. Further research, including explicit evaluation of the effectiveness of different strategies, is needed. |
### Instruction:
Are haptoglobin serum levels independently associated with insulinemia in overweight and obese women?
### Response:
| Higher haptoglobin serum levels seem to be a strong marker of hyperinsulinemia, independently of BMI, body fat distribution, insulin resistance and related parameters. |
### Instruction:
Are lacunar lesions independently associated with disability and cognitive impairment in CADASIL?
### Response:
| Among the lesions observed on conventional MRI in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the overall lacunar lesion burden seems to have the most important impact on cognitive function and disability. These findings suggest that preventive strategies to dec... |
### Instruction:
Does polyarterial clustered recurrence of cervical artery dissection seem to be the rule?
### Response:
| More often than previously thought, the recurrence of spontaneous cervical artery dissection (sCAD) involves multiple cervical arteries in sequence. sCAD recurrence frequently appears to cluster within the first 2 months after the index event, rather than occurring steadily over time. The prognosis of recurring sCAD ap... |
### Instruction:
Does a vascular endothelial growth factor receptor-2 inhibitor enhance antitumor immunity through an immune-based mechanism?
### Response:
| This is the first report of DC101-induced antitumor immune responses. It establishes the induction of tumor-specific T-cell responses as one consequence of VEGF-R2 targeting with DC101. These data support the development of multitargeted cancer therapy combining immune-based and antiangiogenic agents for clinical trans... |
### Instruction:
Do multidrug resistance proteins predict benefit of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer : International Adjuvant Lung Cancer Trial Biologic Program?
### Response:
| MRP2 expression is an independent prognostic factor in patients with completely resected non-small cell lung cancer but neither MRP1 nor MRP2 was of predictive value in patients enrolled into the IALT. |
### Instruction:
Do histone deacetylase inhibitors affect dendritic cell differentiation and immunogenicity?
### Response:
| HDAC inhibitors exhibit strong immunomodulatory properties in human DCs. Our results support the evaluation of HDAC inhibitors in inflammatory and autoimmune disorders. |
### Instruction:
Are cOX-2 and SCD , markers of inflammation and adipogenesis , related to disease activity in Graves ' ophthalmopathy?
### Response:
| We conclude that inflammation and adipogenesis decrease with a decrease in activity of ophthalmopathy and that the nonsteroidal antiinflammatory drug diclofenac inhibits adipogenesis. This may represent a putative future treatment of endocrine ophthalmopathy. |
### Instruction:
Does direct-to-patient expert system and home INR monitoring improve control of oral anticoagulation?
### Response:
| This novel approach of internet-supervised patient self-management improved time in therapeutic range compared to an anticoagulation clinic. This is the first demonstration of an internet-based expert system enabling remote and effective management of patients on oral anticoagulants. Expert systems may be applicable fo... |
### Instruction:
Does aRC contribute to the inhibitory effect of preconditioning on cardiomyocyte apoptosis?
### Response:
| These data indicate that ARC participates in preconditioning-triggered cardioprotection by interfering with cytochrome c release and caspase-3 activation. |
### Instruction:
Does ergothioneine modulate proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury?
### Response:
| EGT attenuates mesenteric ischemia reperfusion injury in rat intestine by increasing tissue HSP-70 and decreasing TNF-alpha, IL-1beta, MDA, and MPO levels. EGT also improves morphological alterations, which occurred after IR injury after prolonged periods of reperfusion. |
### Instruction:
Is the effect of L-glutamine on mucosal healing in experimental colitis superior to short-chain fatty acids?
### Response:
| L-glutamine enema can accelerate mucosal healing and regeneration in experimentally induced colitis in rats. When compared to glutamine in this study, short-chain fatty acids showed no beneficial effect on colitis. |
### Instruction:
Do adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity?
### Response:
| Adipose tissue is infiltrated with macrophages, and its content of long-chain triacylglycerols and ceramides is increased in subjects with increased LFAT compared with equally obese subjects with normal LFAT content. Ceramides or their metabolites could contribute to adverse effects of long-chain fatty acids on insulin... |
### Instruction:
Does rosuvastatin reduce interleukin-6-induced expression of C-reactive protein in human hepatocytes in a STAT3- and C/EBP-dependent fashion?
### Response:
| Our results show a direct inhibitory effect of rosuvastatin on IL-6-induced expression of CRP in liver cells. Statins may lower CRP by inhibiting its production in the liver rather than by exerting systemic anti-inflammatory effects. The effects of rosuvastatin in reducing the levels of CRP in plasma may have clinical ... |
### Instruction:
Does electroporator with automatic change of electric field direction improve gene electrotransfer in-vitro?
### Response:
| On the basis of our results we can conclude that the new system can be used in in-vitro gene electrotransfer to improve cell transfection by changing electric field direction between electrical pulses, without affecting cell survival. |
### Instruction:
Does analysis of septins across kingdoms reveal orthology and new motifs?
### Response:
| Our studies provide an evolutionary history for this important family of proteins and a framework and consistent nomenclature for comparison of septin orthologs across kingdoms. |
### Instruction:
Are postoperative nausea , vomiting , airway morbidity , and analgesic requirements lower for the ProSeal laryngeal mask airway than the tracheal tube in females undergoing breast and gynaecological surgery?
### Response:
| The ProSeal LMA reduced the absolute risk of postoperative nausea and vomiting by 40% (53-13%). In patients without the need for morphine, the ProSeal LMA reduced the absolute risk of postoperative nausea and vomiting by 23% (37-14%). We conclude that the frequency of postoperative nausea, vomiting, airway morbidity, a... |
### Instruction:
Is cognitive impairment in Alzheimer 's disease modified by APOE genotype?
### Response:
| Memory was more impaired among APOE epsilon4 carriers than among noncarriers. By contrast, naming, executive functions and mental speed were more impaired among APOE epsilon4 noncarriers. This suggests that the APOE genotype modifies the clinical phenotype in terms of cognitive impairment in AD. |
### Instruction:
Do icodextrin and Seprafilm interfere with colonic anastomosis in rats?
### Response:
| Seprafilm does not prevent formation of adhesions as much as icodextrin does, but its effect on the healing of colonic anastomoses is similar. |
### Instruction:
Does the tumor suppressive reagent taurolidine inhibit growth of malignant melanoma -- a mouse model?
### Response:
| The i.p. and i.v. therapies reduce total tumor weight and number of metastatic lesions of disseminated malignant melanoma in a dose-dependent fashion in mice. Our encouraging findings should be further confirmed in clinical studies examining the influence of TRD in patients with disseminated malignant melanoma for whom... |
### Instruction:
Is classification of patients with a clinically isolated syndrome based on signs and symptoms supported by magnetic resonance imaging results?
### Response:
| These data provide justification for the recently proposed clinical classification system to be used in patients who present with a first episode suggestive of MS, in that ;multifocal', based on symptoms and signs, is associated with more lesions on MRI. |
### Instruction:
Do wnt-3a protein promote neuronal differentiation of neural stem cells derived from adult mouse spinal cord?
### Response:
| Wnt-3a has obvious influence on the neuronal differentiation of adult neural stem cell. |
### Instruction:
Is hIF-2alpha downregulation in the absence of functional VHL sufficient for renal cell differentiation?
### Response:
| These results indicate that HIF-2alpha regulation is not sufficient for pVHL-induced renal cell differentiation. We hypothesize that in addition to HIF-2alpha dysregulation, abrogation of additional pVHL functions is required for the initiation of renal carcinogenesis. |
### Instruction:
Does tGF-beta1 release by volatile anesthetics mediate protection against renal proximal tubule cell necrosis?
### Response:
| Volatile anesthetics induce a cytoprotective signaling cascade in proximal tubule cells via membrane externalization of PS initiating TGF-beta1-mediated cytoprotection. |
### Instruction:
Does induction of anti-carbonic-anhydrase-II antibody cause renal tubular acidosis in a mouse model of Sjogren 's syndrome?
### Response:
| CA-II-immunized mice had a urinary acidification defect, which may be similar to that seen in patients with SjS. |
### Instruction:
Does cannabidiol in vivo blunt beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression?
### Response:
| The results of the present study confirm in vivo anti-inflammatory actions of CBD, emphasizing the importance of this compound as a novel promising pharmacological tool capable of attenuating Abeta evoked neuroinflammatory responses. |
### Instruction:
Do race and ethnicity contribute to differences in preoperative urinary incontinence severity or symptom bother in women who undergo stress incontinence surgery?
### Response:
| Factors other than racial/ethnic differences underlie variations in UI symptoms and bother in this group of women who sought surgery for stress incontinence. |
### Instruction:
Do [ The application of artificial dermis and recombinant bFGF afer immersion bath in residual burn wound ]?
### Response:
| Application of artificial dermis and bFGF after immersion bath is safe and effective for the elimination of residual wounds at late postburn stage, and it is also beneficial to control wound infection and promote the wound healing. |
### Instruction:
Do [ Proper time and conditions of aeromedical transportation in critically burn patients ]?
### Response:
| Provide that the conditions were permissive and preparation were adequate, it is safe to carry out aeromedical transportation during shock stage. |
### Instruction:
Do proteomic investigation of human burn wounds by 2D-difference gel electrophoresis and mass spectrometry?
### Response:
| We have used the combined technique, DIGE/mass spectrometry, to capture new insights into cutaneous responses to burn trauma and subsequent processes of early wound healing in humans. This pilot study provides a proteomic snapshot of temporal events that can be used to weave together the interconnected processes that d... |
### Instruction:
Does traditional food diversity predict dietary quality for the Awajún in the Peruvian Amazon?
### Response:
| A traditional food diversity score was a useful tool for predicting nutrient adequacy for the Awajún. Promotion of the Awajún traditional food system should focus on dietary diversity and unique nutrient-dense local foods. |
### Instruction:
Does a school salad bar increase frequency of fruit and vegetable consumption among children living in low-income households?
### Response:
| A salad bar as a lunch menu option in the USDA reimbursable lunch programme can significantly increase the frequency of F&V consumption by elementary-school children living in low-income households. |
### Instruction:
Is loss of MSH2 protein expression a risk factor in early stage cervical cancer?
### Response:
| TMAs are powerful tools for high throughput screening of biological markers for prognostic value in cervical cancer. Absence of MSH2 expression is associated with a high-risk profile in early stage cervical cancer, but does not predict lymph node status with sufficient accuracy to be used in the clinic. |
### Instruction:
Are extra copies of chromosomes 16 and X in invasive breast carcinomas related to aggressive phenotype and poor prognosis?
### Response:
| Polysomy of chromosomes 16 and X was reported as the predominant alteration in phenotypically aggressive breast tumours, characterised by poor differentiation, increased growth potential and impaired prognosis, whereas gain of chromosome X in particular is probably implicated in cell survival. |
### Instruction:
Is metabolic syndrome associated with markers of subclinical atherosclerosis , serum adiponectin and endogenous androgen concentrations in Japanese men with Type 2 diabetes?
### Response:
| The metabolic syndrome, as defined by the IDF, is not significantly associated with subclinical atherosclerosis markers, serum adiponectin, or endogenous androgen concentrations in Japanese men with Type 2 diabetes. |
### Instruction:
Are child and parental personality associated with glycaemic control in Type 1 diabetes?
### Response:
| Glycaemic control in the child was associated with the same child and maternal personality characteristics that influence treatment adherence, health-promoting behaviours and general adjustment in adult populations. In future, studies are needed to examine attitudinal and behavioural mediators of this relationship. It ... |
### Instruction:
Is the NTT gene required for transmitting-tract development in carpels of Arabidopsis thaliana?
### Response:
| This is the first report of a gene that is specifically required for transmitting-tract development in Arabidopsis. Mutations in NTT cause reduced fertility by severely inhibiting pollen-tube movement. The data support the idea that the function of the transmitting tract is to increase fertilization efficiency, particu... |
### Instruction:
Is ciclosporin-induced hypertension associated with increased sodium transporter of the loop of Henle ( NKCC2 )?
### Response:
| Our results pointed to the thick ascending limb of the loop of Henle as an important site of sodium retention in cyclosporine-induced hypertension. This data may have potential clinical implications for the treatment of hypertension induced by cyclosporine. |
### Instruction:
Does thyroid echogenicity predict outcome of radioiodine therapy in patients with Graves ' disease?
### Response:
| In patients with Graves' disease, normoechogenic and large glands are associated with increased radioresistance. |
### Instruction:
Is immune cell BDNF secretion associated with white matter volume in multiple sclerosis?
### Response:
| Immune cell BDNF secretion is associated with the sites of higher inflammatory activity as evidenced by CE lesions and may represent an important factor associated with the WM volume of patients with MS. |
### Instruction:
Is high-normal fasting blood glucose in non-diabetic range associated with increased coronary artery calcium burden in asymptomatic men?
### Response:
| : Fasting blood glucose in the upper normal range appears to be associated with the presence of CAC in apparently non-diabetic Brazilian men. |
### Instruction:
Is hIF-1 alpha expression associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages?
### Response:
| In atherosclerotic plaque, the transcription factor HIF-1 alpha is associated with an atheromatous inflammatory plaque phenotype and with VEGF expression. HIF-1 alpha expression is upregulated in activated macrophages under normoxic conditions. |
### Instruction:
Is the catechol O-methyltransferase Val158Met polymorphism associated with broad-based cognitive functioning in schizophrenia?
### Response:
| Based on the results in our sample, the catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia. |
### Instruction:
Is risk for premenstrual dysphoric disorder associated with genetic variation in ESR1 , the estrogen receptor alpha gene?
### Response:
| These are the first positive (albeit preliminary) genetic findings in this reproductive endocrine-related mood disorder and involve the receptor for a hormone that is pathogenically relevant. |
### Instruction:
Are aNCA detectable in nearly all patients with active severe Wegener 's granulomatosis?
### Response:
| ANCA are detectable in nearly all patients with active severe Wegener's granulomatosis, but approximately 1 of 5 patients with active limited disease are ANCA negative. Immunofluorescence and both direct and capture ELISAs are required for optimal detection, suggesting that ANCA are not recognized equally well by all t... |
### Instruction:
Are aqueous humor levels of asymmetric dimethylarginine ( ADMA ) positively associated with monocyte chemoattractant protein-1 ( MCP-1 ) in patients with uveitis?
### Response:
| The results demonstrated that aqueous humor levels of ADMA were positively associated with MCP-1 in humans. Our present observations suggest that aqueous humor levels of ADMA may be a novel biomarker of inflammation in uveitis. |
### Instruction:
Does mDM2 antagonist Nutlin-3 suppress the proliferation and differentiation of human pre-osteoclasts through a p53-dependent pathway?
### Response:
| These findings indicate that Nutlin-3 abrogates both pre-osteoclastic proliferation and differentiation through a p53-dependent pathway and may have therapeutic implications for those neoplastic diseases characterized by an abnormal osteoclastic activity. |
### Instruction:
Is endothelin-converting enzyme-1b C-338A polymorphism associated with the increased risk of coronary artery disease in Chinese population?
### Response:
| Our results suggested that ECE-1b-338C to A variant might be associated with increased risk of CAD in Chinese population. |
### Instruction:
Are patients with sporadic duodenal adenoma a high-risk group for advanced colorectal neoplasia : results of a case-control study?
### Response:
| The relative risk of advanced colorectal adenoma and advanced neoplasia in cases was nine- to 10-fold that among controls. Patients with sporadic duodenal adenoma represent a high-risk group for advanced colorectal neoplasia and should therefore undergo complete colonoscopy. |
### Instruction:
Does strict glycemic control reduce EuroSCORE expected mortality in diabetic patients undergoing myocardial revascularization?
### Response:
| Optimal glucose control highly reduces EuroSCORE expected mortality in diabetic patients undergoing myocardial revascularization, especially in moderate- to high-risk patients. |
### Instruction:
Do trends in melanoma epidemiology suggest three different types of melanoma?
### Response:
| Temporal trends suggest the existence of three unrelated types of melanoma: type I, thick melanomas, with stable incidence; type II, thin melanoma with a steady and important increase in incidence, mainly located on the trunk; and type III, melanoma with a slower increase in incidence, mainly located on the head and ne... |
### Instruction:
Does evidence-based rationale support a national periodontal disease screening program?
### Response:
| The final PS model within the Austrian PHE is based on a wealth of data justifying an evidence-based intervention. The Austrian population is likely to benefit in many ways from the intervention through increased awareness of PD and through a collaboration of medical and dental clinicians in their prevention. |
### Instruction:
Does a novel alphavirus vaccine encoding prostate-specific membrane antigen elicit potent cellular and humoral immune responses?
### Response:
| PSMA-VRP elicited potent cellular and humoral immunity in mice, and specific anti-PSMA responses were boosted on repeat dosing. PSMA-VRP represents a promising approach for immunotherapy of prostate cancer. |
### Instruction:
Does protein kinase D regulate several aspects of development in Drosophila melanogaster?
### Response:
| Our data confirm the hypothesis that Drosophila PKD is a multifunctional kinase involved in diverse processes such as regulation of the cytoskeleton, cell proliferation and death as well as differentiation of various fly tissues. |
### Instruction:
Does dissociation predict symptom-related treatment outcome in short-term inpatient psychotherapy?
### Response:
| Dissociation has a negative impact on treatment outcome. It is suggested that dissociative subjects dissociate as a response to negative emotions arising in psychotherapy leading to a less favourable outcome. Additionally, dissociative patients may have an insecure attachment pattern negatively affecting the therapeuti... |
### Instruction:
Does previous heat shock facilitate the glutamine-induced expression of heat-shock protein 72 in septic liver?
### Response:
| These results demonstrated that Hsp72 could be induced by glutamine in septic liver only if the liver was preconditioned by heat-shock response. The selective facilitating effect might depend on the accumulation of intranuclear phosphorylated HSF-1 caused by previous heat-shock treatment. |
### Instruction:
Does vaccination against VEGFR2 attenuate initiation and progression of atherosclerosis?
### Response:
| These data indicate the prominent role of VEGFR2+ cells in cardiovascular diseases and show that induction of cellular immunity against atherosclerosis-associated cells by means of DNA vaccination may contribute to the development of novel therapies against atherosclerosis. |
### Instruction:
Are oral pantoprazole in the form of granules or tablets pharmacodynamically equivalent in suppressing acid output in patients with gastro-oesophageal reflux disease and a history of erosive oesophagitis?
### Response:
| Patients with gastro-oesophageal reflux disease who are unable to swallow the tablet may safely be prescribed the pantoprazole sodium granules. |
### Instruction:
Is time-of-intake ( morning versus evening ) of extended-release fluvastatin in hyperlipemic patients without influence on the pharmacodynamics ( mevalonic acid excretion ) and pharmacokinetics?
### Response:
| This study demonstrates that fluvastatin ER is equally effective in inhibiting cholesterol biosynthesis when given once daily in the morning and once daily in the evening. |
### Instruction:
Does anti-LFA-1 monotherapy prevent neointimal formation in a murine model of transplant intimal hyperplasia?
### Response:
| We have demonstrated for the first time that LFA-1alpha blockade on its own can prevent development of TIH in an experimental model. The concept of modulating LFA-1alpha-mediated leukocyte migration and T-cell activation may therefore be of relevance to clinical cardiac transplantation and, as such, represents a potent... |
### Instruction:
Does hyaluronan inhibit cytokine production by lipopolysaccharide-stimulated U937 macrophages through down-regulation of NF-kappaB via ICAM-1?
### Response:
| HA of intrinsic molecular weight suppresses LPS-stimulated production of proinflammatory cytokines via ICAM-1 through down-regulation of NF-kappaB and IkappaB. Exogenous HA injected into arthritic joints could act as an anti-NF-kappaB agent by the mechanism demonstrated in the present study. |
### Instruction:
Does temporal thermometry fail to track body core temperature during heat stress?
### Response:
| These results demonstrate that temporal scanning does not track internal temperature, as measured via intestinal temperature, during passive heating. Given these findings, it is recommended that this technique not be used to assess temperature in hyperthermic diaphoretic subjects. |
### Instruction:
Does omega-3 fatty acid regulate inflammatory cytokine/mediator messenger RNA expression in Porphyromonas gingivalis-induced experimental periodontal disease?
### Response:
| These findings suggest that diets enriched for omega-3 FA modulate the local gingival inflammatory milieu of the host following oral P. gingivalis infection, which impacts on alveolar bone resorption in rats. |
### Instruction:
Is one of two gbpC gene homologues involved in dextran-dependent aggregation of Streptococcus sobrinus?
### Response:
| These results suggest that the dbl gene is very likely responsible for S. sobrinus dextran-dependent aggregation. |
### Instruction:
Does genetic disruption of dopamine production result in pituitary adenomas and severe prolactinemia?
### Response:
| Our observations are consistent with the hypothesis that hypothalamic dopamine is a critical inhibitor of lactotroph proliferation and suggest additional roles for dopamine in the regulation of pituitary function. |
### Instruction:
Do light and darkness fail to regulate melatonin release in critically ill humans?
### Response:
| The physiological regulation of melatonin secretion by darkness and light is abolished in severely ill patients. |
### Instruction:
Is vascular remodeling a feature of asthma and nonasthmatic eosinophilic bronchitis?
### Response:
| Vascular remodeling is a feature of asthma, and EB and is inversely associated with the postbronchodilator FEV(1) in asthma, suggesting that vascular remodeling is associated with airflow obstruction but not AHR. |
### Instruction:
Does gonadotropin-releasing hormone agonist decrease chemotherapy-induced gonadotoxicity and premature ovarian failure in young female patients with Hodgkin lymphoma?
### Response:
| Cotreatment with GnRH-a may reduce ovarian damage significantly in female patients treated for HL and should be considered in addition to assisted reproduction for women in reproductive age receiving gonadotoxic chemotherapy. |
### Instruction:
Is treatment with recombinant human erythropoietin associated with rejuvenation of CD8+ T cell compartment in chronic renal failure patients?
### Response:
| We found that the administration of rHuEpo caused rejuvenation of cellular CD8+ T-dependent immunity in our patients. |
### Instruction:
Is laryngeal exposure during laryngoscopy better in the 25 degrees back-up position than in the supine position?
### Response:
| During laryngoscopy, the laryngeal view, as assessed by POGO scores, improves significantly in the 25 degrees back-up position when compared with the flat supine position. |
### Instruction:
Does ten-year follow-up of laparoscopic Heller myotomy for achalasia show durability?
### Response:
| Most patients who underwent LHM with partial fundoplication reported satisfaction 10 years after the operation. A small number of patients required additional intervention. Dysphagia scores at 10 years were not different from those collected at short-term follow-up. Our data suggest that the efficacy of LHM is sustaine... |
### Instruction:
Does steatosis predict postoperative morbidity following hepatic resection for colorectal metastasis?
### Response:
| Steatosis is associated with increased morbidity following hepatic resection. Other predictors of outcome were extent of hepatic resection and blood transfusion. |
### Instruction:
Does pseudodynamic MRI differ from natural opening of the temporomandibular joint?
### Response:
| A method was provided to detect motion during MRI scan using optoelectronic tracking. Pseudodynamic motion may differ from natural motion. |
### Instruction:
Do comparison of fibrin glue and sutures for conjunctival closure in pars plana vitrectomy?
### Response:
| Fibrin glue causes less postoperative pain, discomfort, and sick leave for closure of conjunctival wounds in 20-gauge pars plana vitrectomy than sutures, and therefore, appears in our hands to be a better alternative to sutures. |
### Instruction:
Is neutrophil CD64 expression associated with severity and prognosis of disseminated intravascular coagulation?
### Response:
| Neutrophil CD64 expression is significantly correlated with DIC severity and has a good predictive value for the 28-day mortality in patients suspected of having DIC. Neutrophil CD64 expression might be useful in monitoring the disease course and in predicting mortality in DIC patients. |
### Instruction:
Does infusion of adrenomedullin improve acute myocarditis via attenuation of myocardial inflammation and edema?
### Response:
| Infusion of AM improved cardiac function and pathological findings in a rat model of acute myocarditis. Thus, infusion of AM may be a potent therapeutic strategy for acute myocarditis. |
### Instruction:
Does alendronate have an anabolic effect on bone through the differentiation of mesenchymal stem cells?
### Response:
| This study shows a potential anabolic effect of ALN in vitro through the stimulation of osteogenic differentiation of MSCs. Additionally, a previously unknown inhibitory effect of ALN on bone marrow adipogenesis was also found. |
### Instruction:
Is osteogenic potential of postnatal skeletal muscle-derived stem cells influenced by donor sex?
### Response:
| When stimulated with BMP4, both F- and M-MDSCs underwent osteogenic differentiation, although M-MDSCs had a significantly greater ALP activity and a larger increase in the expression of osteogenic genes than F-MDSCs. In the pellet culture assay, M-MDSCs showed greater mineralization than F-MDSCs. BMP4 stimulation of si... |
### Instruction:
Are type 2 diabetes and metabolic syndrome associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects?
### Response:
| In obese subjects, increased 11beta-HSD1 expression in SAT, but not in VAT, is associated with the worsening of metabolic conditions. We hypothesize that higher glucocorticoid production in adipose tissue would favor the development of metabolic disorders through a decrease in adiponectin release. |
### Instruction:
Is microsurgical lab testing a reliable method for assessing ophthalmology residents ' surgical skills?
### Response:
| These results, along with the findings of our face and content validity analysis, support the reliability and validity of the ESSAT, and indicate that it could be a useful tool for improving the assessment of surgical skill during residency. The ESSAT is a tool that all residency programmes could implement as a part of... |
### Instruction:
Is birth weight nongenetically associated with glucose intolerance in elderly twins , independent of adult obesity?
### Response:
| We demonstrated a genetic component to birth weight in elderly twins. When adjusting for this influence, we found a nongenetic negative association between birth weight and glucose tolerance as well as insulin resistance that was partially independent of adult obesity. This implies that the foetal environment influence... |
### Instruction:
Does acute hyperglycaemia rapidly increase arterial stiffness in young patients with type 1 diabetes?
### Response:
| Acute hyperglycaemia increases the stiffness of intermediate-sized arteries and resistance arteries in young patients with type 1 diabetes and consequently emphasises the importance of strict daily glycaemic control. No change was observed in aortic PWV during the clamp, indicating that acute hyperglycaemia does not af... |
### Instruction:
Does elimination of daily routine chest radiographs change on-demand radiography practice in post-cardiothoracic surgery patients?
### Response:
| Elimination of daily routine chest radiographs led to a decrease of the total number of chest radiographs obtained per patient per day in the intensive care unit and did not change chest radiography practice in the post-intensive care unit ward. |
### Instruction:
Does colchicine inhibit intimal hyperplasia and leukocyte VEGF expression in dogs?
### Response:
| This study demonstrates that oral colchicine for 2 wk significantly reduces intimal hyperplasia following balloon angioplasty in dogs through down-regulation of leukocyte VEGF expression and without apparent toxicity. |
### Instruction:
Does nocistatin inhibit 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways?
### Response:
| We conclude that b-NST inhibits [(3)H]5-HT release via activation of G(i/o) protein linked pathways, not involving classical opioid receptors and the NOP receptor. The present data strengthen the view that b-NST is, per se, a biologically active peptide endowed with agonist activity. |
### Instruction:
Does intraglandular application of botulinum toxin lead to structural and functional changes in rat acinar cells?
### Response:
| Intraglandular application of BoNT induces structural and functional changes of the salivary glands indicated by glandular atrophy. These effects may be due to glandular denervation induced by the inhibition of the soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors (SNAREs) involved in acety... |
### Instruction:
Does transcriptional functionality of germ line p53 mutants influence cancer phenotype?
### Response:
| These findings establish for the first time significant correlations between the residual transactivation function of individual TP53 alleles and clinical variables in patients with inherited p53 mutations who develop cancer. |
### Instruction:
Is the period of hypotension following orthostatic challenge prolonged in dementia with Lewy bodies?
### Response:
| Patients with DLB react different to orthostatic challenge than patients with AD or controls, with important clinical implications for key disease symptoms and treatment. |
### Instruction:
Does a sphingosine kinase 1 mutation sensitize the myocardium to ischemia/reperfusion injury?
### Response:
| Deletion of the SphK1 gene sensitizes the myocardium to IR injury and appears to impair the protective effect of IPC. These data provide the first genetic evidence that the SphK1-S1P pathway is a critical mediator of IPC and cell survival. |
### Instruction:
Do older elite football players have reduced cardiac and osteoporosis risk factors?
### Response:
| Elite athlete physical activity status in young adulthood, and remaining physically active in middle age, may confer body composition changes that are sustained in older adulthood. In this small sample of older men, former successful professional athletes who remained physically active in middle age have a favorable bo... |
### Instruction:
Does facial pain induce the alteration of transient receptor potential vanilloid receptor 1 expression in rat trigeminal ganglion?
### Response:
| Facial inflammatory pain could induce hyperalgesia to noxious heat and cold stimuli, and result in increase of the numbers of TRPV1 positive TG neurons and the peripheral and central terminals of TG. These results suggest that the phenotypic changes of TRPV1 expression in small and medium-sized TG neurons and terminals... |
### Instruction:
Does characteristics of organizational resources and support for self management in primary care?
### Response:
| Establishing a comprehensive system of care for people with diabetes is enabled by an infrastructure of organizational resources and supports for self-management in primary care settings. These components of organizational support provide guidance for integrating diabetes self-management services into primary care sett... |
### Instruction:
Is the circadian system a target and modulator of prenatal cocaine effects?
### Response:
| These findings demonstrate that, in a diurnal vertebrate, prenatal cocaine can acutely dysregulate the expression of circadian genes and those affecting melatonin signaling, growth and neurotransmission, while repeated cocaine exposure can alter neuronal development. Daily variation in these effects of cocaine and thei... |
### Instruction:
Are variants of the TCF7L2 gene associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men?
### Response:
| The association between the risk alleles of the two SNPs studied and levels of proinsulin in plasma, identified when adjusting for insulin sensitivity using euglycaemic-hyperinsulinaemic clamp measurements in this study, is an important novel finding. |
### Instruction:
Do subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice?
### Response:
| Our results provide an accurate representation of subtle changes in metabolic and gene expression regulation underlying disease-promoting and compensatory mechanisms, collectively contributing to diet-induced insulin resistance and NAFLD. They suggest that proposed models of NAFLD pathogenesis can be enriched with nove... |
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