question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Is inhibition of caspase-9 activation and apoptosis involved in ischemic preconditioning-induced neuroprotection in rat brain?
### Response:
| These findings confirm that IPC is capable of protecting neurons from injury by apoptosis. The release of cytochrome c to the cytosol demonstrates that the mitochondrial pathway was involved, and the reduction in this release caused by IPC was clearly associated with reduced caspase-9 activation. Together, these result... |
### Instruction:
Do patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controls?
### Response:
| Patients with RA had markedly higher MBL levels than their close relatives and controls, indicating that high MBL may predispose to RA. As MBL has been shown to bind potential arthritogenic agents including modified immunoglobulins, cellular debris, and microorganisms, our findings suggest that high MBL could trigger c... |
### Instruction:
Is sampling time crucial for measurement of aerobic exercise-induced oxidative stress?
### Response:
| There is no best time point applying to all markers for collecting blood samples after aerobic exercise. The optimum postexercise time points for blood collection in untrained individuals are immediately after exercise for catalase, 1 h for TBARS, 2 h for TAC, GSH, and GSSG, and 4 h after exercise for protein carbonyls... |
### Instruction:
Does progressive dehydration cause a progressive decline in basketball skill performance?
### Response:
| Basketball players experienced a progressive deterioration in performance as DEH progressed from 1 to 4%. The threshold, or % DEH at which the performance decrement reached statistical significance, was 2% for combined timed and shooting drills. |
### Instruction:
Does modulation of glucose metabolism inhibit hypoxic accumulation of hypoxia-inducible factor-1alpha ( HIF-1alpha )?
### Response:
| The effect of glycolysis modulation on the HIF-1alpha levels in tumor cells may provide a novel approach to therapeutically target HIF-1alpha. |
### Instruction:
Does clinical response to glatiramer acetate correlate with modulation of IFN-gamma and IL-4 expression in multiple sclerosis?
### Response:
| Lymphoproliferation to GA did not differentiate GA-R from GA-HR/NR. However, reduced IFN-gamma expression and stable IL-4 expression in anti-CD3/CD28-stimulated PBMC, and an increased IL-4/IFN-gamma ratio was associated with favorable clinical response. More data are needed to validate the prospective use of IL-4/IFN-g... |
### Instruction:
Are morphological and behavioral consequences of recurrent seizures in neonatal rats associated with glucocorticoid levels?
### Response:
| Neonatal recurrent seizures can biphasely modulate neurogenesis over different time windows with a down-regulation at early time and up-regulation afterwards, cause persistent deficits in cognitive functions of adults, and increase the circulating CORT levels. CORT levels are related with the morphological and behavior... |
### Instruction:
Do parameters obtained by hepatobiliary scintigraphy have significant correlation with biochemical factors early after liver transplantation?
### Response:
| A significant correlation between early postoperative scintigraphic results and biochemical parameters was demonstrated. |
### Instruction:
Do dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization?
### Response:
| There is a dynamic regulation of MTHFR gene expression during the arterialization process of human saphenous vein grafts resulting in lower levels of gene expression when in an arterial hemodynamic condition. In addition, the C677T MTHFR functional variant is associated with a worse outcome in individuals submitted to ... |
### Instruction:
Does polyglutamine variation in a flowering time protein correlate with island age in a Hawaiian plant radiation?
### Response:
| In the Hawaiian mint FCA system, we infer that contraction of slightly deleterious CAG repeats occurred because of competition for resources along the natural environmental cline of the island chain. The observed geographical structure of FCA variation and its correlation with morphologies expected from Arabidopsis mut... |
### Instruction:
Is a major genetic locus controlling natural Plasmodium falciparum infection shared by East and West African Anopheles gambiae?
### Response:
| Detection of a malaria-control locus at the same chromosomal location in both East and West African mosquitoes indicates that, to the level of genetic resolution of the analysis, the same mechanism of Plasmodium-resistance, or a mechanism controlled by the same genomic region, is found across Africa, and thus probably ... |
### Instruction:
Is pNRC a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription?
### Response:
| Here, we demonstrate that human PNRC stimulates RNA pol III transcription through its interaction with the subunit RPC39 of RNA pol III.PNRC is a unique coactivator that has profound effects on many aspects of cellular function by directly influencing both RNA pol II- and RNA pol III-dependent transcription. |
### Instruction:
Do cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system?
### Response:
| We describe microarray-based strategies for generating expression profiles of embryonic and larval C. elegans neurons. These methods can be applied to particular neurons at specific developmental stages and, therefore, provide an unprecedented opportunity to obtain spatially and temporally defined snapshots of gene exp... |
### Instruction:
Do structural variations in a single hyaluronan derivative significantly alter wound-healing effects in the rabbit maxillary sinus?
### Response:
| Chemical composition has a significant impact on the clinical potential of modified HA materials. Histocompatibility appears to most significantly affect ostium preservation. |
### Instruction:
Is endothelial nitric oxide synthase Glu298Asp gene polymorphism associated with hypertensive response to exercise in well-controlled hypertensive patients?
### Response:
| In our study, eNOS Glu298Asp polymorphism was significantly associated with HRE. This result suggests that the presence of T allele of the Glu298Asp polymorphism may be a favorable factor to in preventing HRE, especially in female and patients without insulin resistance. |
### Instruction:
Does prostaglandin E1 improve survival rate after 95 % hepatectomy in rats?
### Response:
| Our results suggest that PGE1 may prevent acute liver failure after massive hepatectomy, at least in part, by enhancing HSP70 production in the residual liver. |
### Instruction:
Does cancer cell-derived IL-1alpha induce IL-8 release in endothelial cells?
### Response:
| IL-1alpha is constitutively expressed in many human cancer cells and directly induces IL-8 secretion in neighboring endothelial cells. |
### Instruction:
Do corn fiber oil and sitostanol decrease cholesterol absorption independently of intestinal sterol transporters in hamsters?
### Response:
| The present results show that the CFO-induced and sitostanol-induced decrease in cholesterol absorption is independent of intestinal enterocyte sterol transporters such as ABCG5, ABCG8 and NPC1L1 in hamsters. |
### Instruction:
Are disparities in health care driven by where minority patients seek care : examination of the hospital quality alliance measures?
### Response:
| Disparities in clinical process of care measures are largely the result of differences in where minority and nonminority patients seek care. However, disparities in services requiring counseling exist within hospitals after controlling for site of care. Policies to reduce disparities should consider the underlying reas... |
### Instruction:
Is the I allele of the ACE gene associated with improved exercise capacity in women with McArdle disease?
### Response:
| The I allele of the ACE gene is associated with a higher functional capacity in female patients, and might partly explain the individual variability in the phenotypic manifestation of McArdle disease. |
### Instruction:
Does overestimation of stability limits lead to a high frequency of falls in patients with Parkinson 's disease?
### Response:
| These results indicated that patients with Parkinson's disease overestimated their stability limits, which may result in falls. In addition, the results demonstrate that patients with Parkinson's disease develop overestimation of stability limits in parallel with their disease progression. |
### Instruction:
Does high-frequency whole-body vibration improve balancing ability in elderly women?
### Response:
| WBV was effective in improving the balancing ability in elderly women. This also provides evidence to support our user-friendly WBV treatment protocol of 3 minutes a day for the elderly to maintain their balancing ability and reduce risks of fall. |
### Instruction:
Does arachidonic acid and docosahexaenoic acid supplementation increase coronary flow velocity reserve in Japanese elderly individuals?
### Response:
| Three months' supplementation of PUFA increased CFVR in Japanese elderly individuals, which suggests beneficial effects of PUFA on the coronary microcirculation. |
### Instruction:
Is age alone a risk factor for left atrial thrombus in atrial fibrillation?
### Response:
| In patients with atrial fibrillation, age itself does not predict the presence of left atrial thrombus and the only identifiable risk factor seems to be the existing cardiac pathology. |
### Instruction:
Are mild prevalent and incident vertebral fractures risk factors for new fractures?
### Response:
| Mild vertebral fractures are a risk factor for subsequent vertebral and non-vertebral fracture in postmenopausal women with osteoporosis; 1 out of 4 patients with an incident mild vertebral fracture in 2 years will fracture again within the 2 next years. |
### Instruction:
Do beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis?
### Response:
| Our data show how beta1AR-specific autoantibodies elicit DCM by agonistically inducing cardiomyocyte apoptosis. |
### Instruction:
Do men with Kennedy disease have a reduced risk of androgenetic alopecia?
### Response:
| Men with KD have a reduced risk of AGA, likely to be due to a functional alteration in the AR caused by the polyglutamine expansion. |
### Instruction:
Is upper arm circumference associated with race performance in ultra-endurance runners?
### Response:
| In an ultra-endurance run over 1200 km within 17 consecutive days, circumference of the upper arm was the only factor associated with performance in well-experienced ultra-endurance runners. Body mass, BMI, body height, length of limbs, skin-fold thicknesses, circumference of limbs and the calculated percentage body co... |
### Instruction:
Is an N-terminal molecular form of parathyroid hormone ( PTH ) distinct from hPTH ( 1 84 ) overproduced in parathyroid carcinoma?
### Response:
| N-PTH is overproduced in some parathyroid cancer patients, but calcimimetic therapy does not influence its production. The clinical implications of this finding in parathyroid carcinoma await additional studies with an emphasis on N-PTH's biological activity and with larger numbers of patients. |
### Instruction:
Are oxidative stress markers associated with persistent atrial fibrillation?
### Response:
| These data suggest that oxidative stress markers may have predictive value in AF management. |
### Instruction:
Are the ankle-brachial pressure index and a standardized questionnaire easy and useful tools to detect peripheral arterial disease in non-claudicating patients at high risk?
### Response:
| ABI detects PAD in a considerable number of asymptomatic patients at increased risk and followed in general practice. When properly questioned almost half of these patients appear to have intermittent claudication. |
### Instruction:
Is detection of MAGE-A transcripts in bone marrow an independent prognostic factor in operable non-small-cell lung cancer?
### Response:
| Detection of MAGE-A transcripts in bone marrow predicts an unfavorable outcome in patients with early-stage operable lung cancer. This finding indicates that MAGE-A transcripts are clinically relevant markers of micrometastatic spread in lung cancer and supports further investigation of MAGE-A as potential future thera... |
### Instruction:
Does up-regulation of tumor susceptibility gene 101 convey poor prognosis through suppression of p21 expression in ovarian cancer?
### Response:
| TSG101 negatively regulates p21 levels, and up-regulation of TSG101 is associated with poor prognosis in ovarian cancer. |
### Instruction:
Is migraine with aura a risk factor for cardiovascular and cerebrovascular disease : a critically appraised topic?
### Response:
| In women, active migraine with aura increases the risk of major CVD and ischemic stroke by approximately 2-fold compared with women without migraine. Active migraine without aura was not a risk factor for major CVD and stroke outcomes in this study. Additional emphasis on identification and treatment of modifiable vasc... |
### Instruction:
Do sentinel node micrometastases have high proliferative potential in gastric cancer?
### Response:
| We showed that micrometastasis and some ITCs in SNs had proliferative activity. We suggest that micrometastasis and ITCs should be removed, especially during SN navigation surgery, until their clinical significance is clarified. |
### Instruction:
Are youth with psychopathy features a discrete class : a taxometric analysis?
### Response:
| Although youth clearly vary in the degree to which they manifest psychopathy-like personality traits, there is no natural, discrete class of young 'psychopaths.' This finding has implications for developmental theory, treatment, assessment strategies, research, and clinical/forensic practice. |
### Instruction:
Is odontoid fractures in the elderly : dorsal C1/C2 fusion superior to halo-vest immobilization?
### Response:
| Posterior stabilization of unstable odontoid fractures with transarticular screws and modified Gallie fusion in old patients can be performed safely, with good clinical results and few complications. However, mortality remains high, but is lower than reported after halo-vest immobilization alone. Dorsal C1/C2 Fusion is... |
### Instruction:
Do iCU discharge APACHE II scores help to predict post-ICU death?
### Response:
| In our study, a higher APACHE II score calculated at ICU discharge and male gender were independent risk factors for post-ICU death. Identifying patients with discharge APACHE II scores of 17 or greater helps to predict post-ICU death. |
### Instruction:
Is high-grade dysplasia in Barrett 's esophagus associated with increased expression of calgranulin A and B?
### Response:
| This is the first report of an association between the calprotectin complex, which is involved in chemotaxis of neutrophils, and the progression towards high-grade dysplasia in BE. It remains to be established whether differentially expressed proteins in biopsies form BE can be used to facilitate the diagnosis of advan... |
### Instruction:
Does cross-sectional imaging identify flow-mediated vasodilatation more accurately compared with longitudinal imaging?
### Response:
| Cross-sectional imaging produced a much larger change in area and pixels compared with longitudinal imaging. This translates into greater sensitivity in detecting small changes produced by FMD. |
### Instruction:
Does residual ductal carcinoma in situ in patients with complete eradication of invasive breast cancer after neoadjuvant chemotherapy adversely affect patient outcome?
### Response:
| Residual DCIS in patients who experience complete eradication of the invasive cancer in the breast and lymph nodes does not adversely affect survival or local recurrence rate. Inclusion of patients with residual DCIS in the definition of pCR is justified when this outcome is used as an early surrogate for long-term sur... |
### Instruction:
Does neuregulin expression modulate clinical response to trastuzumab in patients with metastatic breast cancer?
### Response:
| We suggest that the spectrum of patients who may benefit from trastuzumab-based therapies may be widened to include patients with metastatic breast cancer without HER-2 amplification but who express transmembrane NRGs. |
### Instruction:
Do lung cancer with isolated skip metastasis to an abdominal lymph node?
### Response:
| The low incidence reported for skip metastasis to the abdominal lymph nodes may be attributed to an underestimation in the past. With the advent of PET computed tomography (PET-CT) and its use as a standard pre-operative staging modality for lung cancer, one should anticipate an increased incidence of skip metastasis. |
### Instruction:
Is pulse pressure an independent predictor of aortic stiffness in patients with mild to moderate chronic kidney disease?
### Response:
| The results of this study confirm an aPWV increase in mild to moderate CKD and emphasize association between pulse pressure and PWV, independently of renal failure. |
### Instruction:
Do lactate and glycerol released to the intestinal lumen reflect mucosal injury and permeability changes caused by strangulation obstruction?
### Response:
| Microdialysis of lactate and glycerol in the intestinal lumen may be used to assess structural and functional changes of the intestinal mucosa after strangulation obstruction. |
### Instruction:
Do trajectories of socioeconomic status across children 's lifetime predict health?
### Response:
| These findings suggest that the accumulation of socioeconomic status in terms of family income across childhood is more important than social mobility or variability in socioeconomic status, although there may be certain periods of time (early life) that have stronger effects on health. These findings suggest the impor... |
### Instruction:
Do magnetic resonance imaging regional T1 abnormalities at term accurately predict motor outcome in preterm infants?
### Response:
| Lesions in the corona radiata above the posterior limb of the internal capsule on a coronal view by term MRI were useful for predicting motor prognosis in preterm infants with periventricular leukomalacia. |
### Instruction:
Does antisense RNA decrease AP33 gene expression and cytoadherence by T. vaginalis?
### Response:
| These results using both antisense inhibition of gene expression and AP33 synthesis and the heterologous expression of AP33 in T. foetus confirms a role for this protein as an adhesin in T. vaginalis. |
### Instruction:
Does major depression in older medical inpatients predict poor physical and mental health status over 12 months?
### Response:
| A diagnosis of major depression in cognitively intact older medical inpatients is associated with sustained poor physical and mental health status over the following 12 months. |
### Instruction:
Does experimental osteoporosis induced by ovariectomy and vitamin D deficiency markedly affect fracture healing in rats?
### Response:
| Our results suggest that the systemic effects of estrogen and vitamin D deficiency are not crucial for fracture healing or mechanical properties of the callus. |
### Instruction:
Do surface-bound bisphosphonates enhance screw fixation in rats -- increasing effect up to 8 weeks after insertion?
### Response:
| The energy uptake and pull-out force of a screw depends on the bone engaged with the threads. Thus, the presence of bisphosphonates increased the amount or quality of this bone by affecting the resorption/formation in a positive way. The increased effect of the bisphosphonates with time thus suggests that bisphosphonat... |
### Instruction:
Are ghrelin and motilin cosecreted from a prominent endocrine cell population in the small intestine?
### Response:
| The upper small intestine is an important source of ghrelin. The likely cosecretion of intestinal ghrelin and motilin suggests concerted actions of the two hormones. These data may have implications for understanding gut motility and clinical implications for dysmotility and bariatric surgery. |
### Instruction:
Do testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue?
### Response:
| Testicular adrenal rest tumors produce adrenal-specific steroids and express adrenal-specific enzymes and ACTH and AII receptors, confirming the strong resemblance with adrenal tissue. Because AII receptors are present in tumor tissue, it can be hypothesized that AII may be an additional factor responsible for testicul... |
### Instruction:
Are plasma osteopontin levels and expression in adipose tissue increased in obesity?
### Response:
| These findings represent the first observation that plasma OPN and mRNA expression of OPN in omental adipose tissue are increased in overweight/obese patients with the latter being further elevated in obesity-associated diabetes. Moreover, weight loss reduces OPN concentrations, which may contribute to the beneficial e... |
### Instruction:
Does adenosine instead of supranormal potassium in cardioplegic solution improve cardioprotection?
### Response:
| Adenosine instead of supranormal potassium in cold crystalloid cardioplegia gives satisfactory cardiac arrest, improves post cardioplegic left ventricular systolic function and efficiency, and attenuates myocardial cell damage. |
### Instruction:
Is cYP2R1 ( vitamin D 25-hydroxylase ) gene associated with susceptibility to type 1 diabetes and vitamin D levels in Germans?
### Response:
| Thus, our findings reveal a novel association of CYP2R1 polymorphisms in patients with type 1 diabetes and with their circulating levels of 25(OH)D3. |
### Instruction:
Are immunosuppressive dendritic and regulatory T cells upregulated in melanoma patients?
### Response:
| Advanced melanoma is associated with increased numbers of circulating dendritic cells and regulatory T cells. These data suggest that melanoma induces immunosuppressive DCs and regulatory T cells in the systemic circulation. |
### Instruction:
Does young age influence treatment but not outcome of colon cancer?
### Response:
| Younger patients undergoing complete resection of stage I-III colon cancer had DSS similar to older patients. However, younger patients had more nodes retrieved from their specimens and were more likely to receive adjuvant therapy, especially for node-negative disease. These factors may have contributed to their overal... |
### Instruction:
Do [ Repair of electric burn wound in the upper limbs with lateral intercostal perforator-based pedicled flap ]?
### Response:
| This flap is suitable for the repair of deep wounds in hands, forearms, and elbows. |
### Instruction:
Does eDR2 negatively regulate salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thaliana?
### Response:
| EDR2 acts as a negative regulator of cell death, specifically the cell death elicited by pathogen attack and mediated by the salicylic acid defense pathway. Phosphatidylinositol-4-phosphate may have a role in limiting cell death via its effect on EDR2. This role in cell death may be indirect, by helping to target EDR2 ... |
### Instruction:
Does mast cell stabilization reduce hemorrhage formation and mortality after administration of thrombolytics in experimental ischemic stroke?
### Response:
| MCs appear to play an important role in HF and reperfusion injury after tPA administration. Pharmacological stabilization of MCs could offer a novel type of therapy to improve the safety of administration of thrombolytics. |
### Instruction:
Do cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly?
### Response:
| Low Abeta42 and combined Abeta42 and P-tau predicted subjective cognitive decline in healthy individuals. In summary, this study shows that already in the clinically normal population Alzheimer-disease-related biological signs might be detectable. |
### Instruction:
Does low-dose parenteral busulfan provide an extended window for the infusion of hematopoietic stem cells in murine hosts?
### Response:
| Nonmyeloablative parenteral busulfan produced transient myelosuppressive effects, clinically relevant levels of engraftment, and an extended time window for HSC infusion in murine hosts. |
### Instruction:
Does pre-operative mild cognitive dysfunction predict risk for post-operative delirium after elective cardiac surgery?
### Response:
| The main pre-operative risk factors for post-operative delirium after elective cardiac operations were subjective memory complaints, mild cognitive impairment, and type of cardiac surgery, such as valve procedures. This study suggests that cognitive evaluation should be included in pre-operative assessment. |
### Instruction:
Does coating with paclitaxel improve graft survival in a porcine model of haemodialysis graft stenosis?
### Response:
| Double-coating with paclitaxel improved graft survival. Coated PTFE grafts may be effective for the prevention of graft failure in patients on haemodialysis. |
### Instruction:
Does expression of the obesity hormone leptin and its receptor correlate with hypoxia-inducible factor-1 alpha in human colorectal cancer?
### Response:
| The results indicate that the leptin system is overexpressed in human colorectal cancer and this overexpression appears to be associated with the abundance of HIF-1alpha. |
### Instruction:
Does abrogation of constitutive STAT3 activity sensitize human hepatoma cells to TRAIL-mediated apoptosis?
### Response:
| Abrogation of constitutive activation of STAT3 by AG490 enhances the anti-tumor activity of TRAIL against human hepatoma cells. |
### Instruction:
Do [ BCG cell wall proteins enhance clearance of Pseudomonas aeruginosa in rat lungs ]?
### Response:
| The fraction (relative molecular mass is 18 X 10(3) -30 X 10(3)) of BCG cell wall proteins improve the defense of rat lungs against P. aeruginosa infection. |
### Instruction:
Is c-reactive protein associated with heart rate variability?
### Response:
| C-reactive protein and heart rate variability are independently associated. This may support a link between low-grade inflammation and autonomic dysfunction. |
### Instruction:
Is sTK15 F31I polymorphism associated with increased uterine cancer risk : a pilot study?
### Response:
| Our study demonstrates that STK15 F31I SNP is associated with an increased risk for uterine cancer. Confirmation of this pilot study is needed in a larger case-control population to evaluate this genetic variant with other known risk factors for uterine cancer. |
### Instruction:
Do online behavior of youth who engage in self-harm provides clues for preventive intervention?
### Response:
| Findings suggest that youth who engage in self-harm may be more likely to engage in online behaviors that have the potential to place them in risky situations. Programs aimed at preventing deliberate self-harm should consider adding chat room and instant messaging to their telephone hotline capabilities. |
### Instruction:
Does visual stimulation activate ERK in synaptic and somatic compartments of rat cortical neurons with parallel kinetics?
### Response:
| Visual stimulation in vivo increases pERK expression at pre- and post-synaptic sites of axo-spinous junctions, suggesting that ERK plays an important role in the local modulation of synaptic function. The data presented here support a model in which pERK can have early and late actions both centrally in the cell nucleu... |
### Instruction:
Is transcription factor NF-kappaB transported to the nucleus via cytoplasmic dynein/dynactin motor complex in hippocampal neurons?
### Response:
| This study shows the molecular mechanism for the retrograde transport of activated NF-kappaB from distant synaptic sites towards the nucleus. |
### Instruction:
Does [ Hypoxia promote apoptosis of germ cells in rat testes ]?
### Response:
| Hypoxia promotes apoptosis of testicular germ cells in male rats. Chronic hypoxia increases Bax expression in the rat testis. |
### Instruction:
Does a ketamine-propofol admixture reduce the pain on injection compared with a lidocaine-propofol admixture?
### Response:
| Injection pain was twice as common with ketamine-propofol admixture than with lidocaine-propofol admixture. |
### Instruction:
Are iL-6 and IGF-1 independent prognostic factors of liver steatosis and non-alcoholic steatohepatitis in morbidly obese patients?
### Response:
| The concentration of glucose, insulin, IL-6 and IGF-1 in blood are useful markers for the selection of patients with liver steatosis or NASH. |
### Instruction:
Does levator ani abnormality 6 weeks after delivery persist at 6 months?
### Response:
| Nulliparity did not guarantee a normal assessment of levator ani anatomy by our blinded reader, and frequency of injury in this series is somewhat greater than that previously reported for primiparous women. Younger white primiparous women had a better recovery at 6 months than older white women. Subjects experiencing ... |
### Instruction:
Does lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibit hepatocellular carcinoma growth through down-regulation of stathmin?
### Response:
| Results from our study suggested for the first time that EZH2 plays a key role in HCC tumorigenesis, and is a novel therapeutic target for HCC. |
### Instruction:
Is insulin resistance and liver injury in hepatitis C associated with virus-specific changes in adipocytokines?
### Response:
| Whereas leptin and adiponectin contribute to IR, none of the adipocytokines accounted for the elevated IR in HCV-infected subjects. The adipocytokines were not associated with histological features of chronic HCV infection except for TNFalpha which correlated with portal/periportal inflammation. HCV-associated IR is mo... |
### Instruction:
Is mLF1-interacting protein mainly localized in nucleolus through N-terminal bipartite nuclear localization signal?
### Response:
| MLF1IP was localized mainly in the nucleolus through the N-terminal bipartite NLS and partly in the nucleoplasm featuring small dot-like particles. These findings suggest that MLF1IP may have multi-functions and its different localizations may contribute to carcinogenesis. |
### Instruction:
Do vessel dilator and kaliuretic peptide inhibit MEK 1/2 activation in human prostate cancer cells?
### Response:
| Vessel dilator and kaliuretic peptide both inhibit MEK 1/2 kinase mediated via cyclic GMP as part of their anticancer mechanism(s) of action. |
### Instruction:
Does [ Renal type I inositol 1,4,5-triphosphate receptors expression increase in fulminant hepatic failure in mice ]?
### Response:
| The expression of IP3RI protein increased in glomerular mesangial cells and renal vascular smooth muscle cells of FHF mice. Perhaps this was caused by IP3RI mRNA up-regulation. |
### Instruction:
Is tRPM5 , a taste-signaling transient receptor potential ion-channel , a ubiquitous signaling component in chemosensory cells?
### Response:
| We consider TRPM5 to be an intrinsic signaling component of mammalian chemosensory organs, and provide evidence for brush cells being an important cellular correlate in the periphery. |
### Instruction:
Do mid foot kinetics characterize structural polymorphism in diabetic foot disease?
### Response:
| Diabetic foot disease can be classified as stereotypical, structurally-distinct phenotypes of deformities of the medial and lateral columns of the mid foot. Assessments of pedal bone density and plantar mid foot force and pressure during barefoot walking can characterize the structural polymorphic phenotypes and may as... |
### Instruction:
Is fatigability increased with age during velocity-dependent contractions of the dorsiflexors?
### Response:
| These results demonstrate that older adults are more fatigable than young adults during a velocity-dependent power task. This finding is in contrast to the majority of fatigue data previously reported from less functionally relevant isometric or isokinetic tasks. |
### Instruction:
Are glucose abnormalities an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C?
### Response:
| Glucose abnormalities are an independent predictor of poor virological response to combined therapy in hepatitis C virus infected patients. |
### Instruction:
Is transactivation of the EGFR by AP-1 induced by Helicobacter pylori in gastric cancer?
### Response:
| We conclude that exposure of gastric cells to H. pylori induces increased production of EGFR through various signal transduction pathways, including those mediated by the EGFR and AP-1. Distinct effects on EGFR activation may specify the subset of AP-1 target genes that are selected, including those involved in prolife... |
### Instruction:
Are imbalances in dietary consumption of fatty acids , vegetables , and fruits associated with risk for Crohn 's disease in children?
### Response:
| Our findings indicate that an imbalance in consumption of fatty acids, vegetables, and fruits is associated with increased risks for CD among Canadian children. |
### Instruction:
Is the predictive value for in vitro fertility delivery rates greatly impacted by the method used to select the threshold between normal and elevated basal follicle-stimulating hormone?
### Response:
| The methodology used to select thresholds for basal FSH levels has enormous impact on the utility of the screening test. The use of anything other than clinical outcome-based methods to select the threshold greatly decreases the utility of the test and may lead to false conclusions or inaccurate patient counseling. |
### Instruction:
Does comprehensive expression profiling of tumor cell lines identify molecular signatures of melanoma progression?
### Response:
| We conclude that tumor cell lines are a valuable resource for the early identification of gene signatures associated with malignant progression in tumors with significant heterogeneity like melanoma. We further conclude that the development of novel data reduction algorithms for analysis of microarray studies is critic... |
### Instruction:
Is tripartite motif-containing 29 ( TRIM29 ) a novel marker for lymph node metastasis in gastric cancer?
### Response:
| TRIM29 expression may serve as a good marker of lymph node metastasis in gastric cancer. |
### Instruction:
Does neonatal chlamydial infection induce mixed T-cell responses that drive allergic airway disease?
### Response:
| Early-life chlamydial infection induces a mixed type 1 and 2 T-cell response to antigen, which differentially affects the development of key features of AAD in the adult. |
### Instruction:
Does mitochondrial biogenesis restore oxidative metabolism during Staphylococcus aureus sepsis?
### Response:
| This is the first demonstration that mitochondrial biogenesis restores oxidative metabolism in bacterial sepsis and is therefore an early and important prosurvival factor. |
### Instruction:
Are ki-67 and coagulative tumor necrosis independent predictors of poor outcome for patients with clear cell renal cell carcinoma and not surrogates for each other?
### Response:
| Prognostic information conveyed by Ki-67 and coagulative tumor necrosis are not interchangeable. Thus, Ki-67 and coagulative tumor necrosis should not be treated as surrogates for one another and both of these features should be evaluated when generating outcome predictions for patients with ccRCC. |
### Instruction:
Is detection of M2 antimitochondrial antibodies by dot blot assay more specific than by enzyme linked immunosorbent assay?
### Response:
| Dot blot, using purified pyruvate dehydrogenase, had a higher specificity than ELISA and may be useful in confirming the specificity of AMA in cases of doubt with IIF. |
### Instruction:
Does toxicogenomic analysis of Caenorhabditis elegans reveal novel genes and pathways involved in the resistance to cadmium toxicity?
### Response:
| Because many C. elegans genes and signal transduction pathways are evolutionarily conserved, these results may contribute to the understanding of the functional roles of various genes in cadmium toxicity in higher organisms. |
### Instruction:
Does intracerebroventricular administration of nitric oxide-sensitive guanylyl cyclase inhibitors induce catalepsy in mice?
### Response:
| This study showed that pharmacological disruption of the endogenous NO-sGC signaling in the central nervous system induces long-lasting catalepsy in mice. Moreover, the cataleptic effect of NOS inhibition correlates with the decrease in NO( x ) products formation in the striatum. The results give further support to the... |
### Instruction:
Is a LEEP cervical conization rarely indicated for a two-step discrepancy?
### Response:
| A LEEP cone is rarely indicated for the evaluation of a 2-step discrepancy. A randomized trial of this finding is warranted. |
### Instruction:
Do fungal allergens induce cathelicidin LL-37 expression in chronic rhinosinusitis patients in a nasal explant model?
### Response:
| LL-37 is significantly up-regulated at the mRNA and protein level in CRS patients in response to fungal allergens. However, EMCRS patients do not show increased LL-37 at either the mRNA or the protein level in response to Alternaria. |
### Instruction:
Do functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis?
### Response:
| The data reported here provide direct evidence that some allelic variants or haplogroups of IL-23R represent independent risk factors for rheumatoid arthritis as well as Crohn's disease, but not for scleroderma. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.