question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Is hepatic c-fos expression independent of oxidative stress and inflammation induced by acute cadmium exposure in rats?
### Response:
| Our data suggested that c-fos induction is independent of oxidative stress or inflammation in the liver during the process of acute Cd exposure in rats. |
### Instruction:
Is genetic polymorphism of the adenosine A2A receptor associated with habitual caffeine consumption?
### Response:
| Our findings show that the probability of having the ADORA2A 1083TT genotype decreases as habitual caffeine consumption increases. This observation provides a biologic basis for caffeine consumption behavior and suggests that persons with this genotype may be less vulnerable to caffeine dependence. |
### Instruction:
Is intake of fried foods associated with obesity in the cohort of Spanish adults from the European Prospective Investigation into Cancer and Nutrition?
### Response:
| Fried food was positively associated with general and central obesity only among subjects in the highest quintile of energy intake from fried food. |
### Instruction:
Is prevalence of OME reduced in young children using chewing gum?
### Response:
| In the case of regular use of chewing gum, the probability of having OME in children is reduced by 40%. It seems plausible that children with immature oral motorics do not like chewing gum. |
### Instruction:
Do hemispheric cups reproduce acetabular rim morphology?
### Response:
| It would be difficult to obviate the anterior overlap of the acetabulum using a hemispheric cup, a fortiori in certain morphotypes, without compromising range of motion or risk of dislocation. The solution for prevention of iliopsoas impingement would be to adapt cup design to acetabular anatomy, which may require diff... |
### Instruction:
Does oral infection of mice with Salmonella enterica serovar Typhimurium cause meningitis and infection of the brain?
### Response:
| This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried. |
### Instruction:
Does a specific box switch the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina?
### Response:
| Our data provide molecular evidence on how closely related homeodomain gene products can differentiate their functions to regulate distinct cell fates. A small 'specificity box' is both necessary and sufficient to confer on XOTX2 and XOTX5b their distinct activities in the developing frog retina and to convert the neut... |
### Instruction:
Is gAPDH regulated in human glioblastoma under hypoxic conditions?
### Response:
| GAPDH represents an optimal choice of a housekeeping gene and/or loading control to determine the expression of hypoxia induced genes at least in glioblastoma. Because of the lack of GAPDH regulation under hypoxia, this gene is not an attractive target for tumor therapeutic approaches in human glioblastoma. |
### Instruction:
Is p21/WAF1 an independent survival prognostic factor for patients with hepatocellular carcinoma after resection?
### Response:
| In HCC, increased proliferation index PCNA is significantly associated with positive p53 and p21/WAF1. But p21/WAF1 expression did not relate to p53 expression. P21/WAF1 (+) is a good event and serves as an independent survival prognostic factor for HCC, which is a novel finding apart from previous reports. |
### Instruction:
Is peginterferon alpha-2b safe and effective in HBeAg-positive chronic hepatitis B patients with advanced fibrosis?
### Response:
| PEG-IFN is effective and safe for HBeAg-positive patients with advanced fibrosis. Because PEG-IFN therapy results in a high rate of sustained off-therapy response, patients with advanced fibrosis or cirrhosis but compensated liver disease should not be excluded from PEG-IFN treatment. |
### Instruction:
Does locally applied simvastatin promote fracture healing in ovariectomized rat?
### Response:
| The current study suggests that local application of simvastatin could promote fracture healing in ovariectomized rats. |
### Instruction:
Does a web-based course on complementary medicine for medical students and residents improve knowledge and changes attitudes?
### Response:
| This brief course in CAM improved knowledge, changed attitudes, and was well received. |
### Instruction:
Do [ An update on neurochemistry and pharmacological therapy of the cerebellar ataxias ]?
### Response:
| A systematic search for treatable ataxias is emphasized, as a response to the severity of the degenerative conditions. The use of GABAergic drugs is proposed in ataxias associated with a deficiency of GABA in the brain, and that of glutamatergic agents, for ataxias associated with glutamate deficiency. The use of serot... |
### Instruction:
Does [ Diet-induced obesity affect testis development in pubertal rats ]?
### Response:
| High-fat diet can induce nutritional obesity in pubertal rats, which in turn may lead to the underdevelopment of the testis and the abnormal level of gonadal hormones. |
### Instruction:
Does [ Oral acrylamide affect the development and reproductive performance of male rats ]?
### Response:
| Acrylamide has toxic effects on seminiferous tubules and decreases the production of sperm in male rats. |
### Instruction:
Does exercise echocardiography reveal subclinical cardiac dysfunction in young adult survivors of childhood acute lymphoblastic leukemia?
### Response:
| With very long follow up in a homogenous cohort of ALL survivors, we found subclinical cardiac dysfunction with exercise stress echocardiography even after low doses of AC. |
### Instruction:
Does fMRI reveal that non-local processing in ventral retinotopic cortex underlies perceptual grouping by temporal synchrony?
### Response:
| Nonlocal processing within, between, or to ventral retinotopic cortex at least as early as V2v, and including V3v, and V4v, underlies perceptual grouping via temporal synchrony. |
### Instruction:
Do the effect of distal ulnar implant stem material and length on bone strains?
### Response:
| The results from this study suggest that the optimal stem characteristics for distal ulnar implants from a load transfer point of view are possessed by shorter (approximately 3 to 4 cm) titanium stems. |
### Instruction:
Is serum C3 a stronger inflammatory marker of insulin resistance than C-reactive protein , leukocyte count , and erythrocyte sedimentation rate : comparison study in an elderly population?
### Response:
| Of the four inflammatory markers simultaneously assessed in our elderly population, only C3 was strongly associated with insulin resistance, independently of the components of the metabolic syndrome and the main indexes of abdominal and general obesity. |
### Instruction:
Are nucleoside analogues activated by bacterial deoxyribonucleoside kinases in a species-specific manner?
### Response:
| Bacterial dNKs efficiently activate nucleoside analogues in a species-specific manner. Therefore, nucleoside analogues have a potential to be employed as antibiotics in the fight against emerging multiresistant bacteria. |
### Instruction:
Do single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users?
### Response:
| Repeated lower daily rimonabant doses (40 mg) attenuated the acute physiological effects of smoked cannabis to a similar degree as a single 90-mg dose; repeated 40-mg doses attenuated subjective effects after 8 but not 15 days. |
### Instruction:
Is signal transducer and activator of transcription 3 involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells?
### Response:
| This study demonstrates that Stat3 phosphorylation is elevated in human rhabdomyosarcoma, osteosarcomas and soft-tissue sarcomas. Furthermore, the activated Stat3 pathway is important for cell growth and survival of human sarcoma cells. |
### Instruction:
Is genetic variation in tumour necrosis factor and lymphotoxin associated with endometriosis in an Australian sample?
### Response:
| Our data suggest both TNF and LTA genes are not major susceptibility genes for endometriosis. |
### Instruction:
Does statistical projection of clinical subsample estimate to a survey population?
### Response:
| The proposed projection methodology supports valid inference about clinical outcomes to a broad population using data from a more narrowly defined clinical subsample. This approach is useful in addressing important public health questions until such time as a nationally representative clinical study can be undertaken. |
### Instruction:
Does ketamine increase the frequency of electroencephalographic bicoherence peak on the alpha spindle area induced with propofol?
### Response:
| Ketamine shifted the alpha peaks of bicoherence induced by propofol to higher frequencies. This suggests that ketamine changes the alpha spindle rhythms through the modulation of the nonlinear sub-cortical reverberating network. |
### Instruction:
Does lowering homocysteine decrease levels and expression of VEGF ( 165 ) and endostatin?
### Response:
| These findings demonstrate that lowering of homocysteine with B vitamins and folic acid resulted in substantial reduction of plasma levels of VEGF but minimal reduction of endostatin and in down-regulation of their expression in leukocytes in patients with PAD or DM. |
### Instruction:
Does percutaneous coronary revascularization reduce plasma N-terminal pro-B-type natriuretic peptide concentration in stable coronary artery disease?
### Response:
| This study demonstrates that removal of fixed LAD stenosis reduces plasma NT-proBNP concentration. This has implications for interpretation of natriuretic peptide levels in clinical settings and as screening tool for LV systolic dysfunction. |
### Instruction:
Do [ Clinical application of keratoprosthesis for corneal opacity caused by chemical burn unsuitable for keratoplasty ]?
### Response:
| Keratoprosthesis improves vision of corneal opacity patients with complicated conditions result caused by chemical burn, such as dense neovascularization and severe ocular surface disorders. |
### Instruction:
Does early physiotherapy after injection of botulinum toxin increase the beneficial effects on spasticity in patients with multiple sclerosis?
### Response:
| Our data suggest that physiotherapy in combination with botulinum toxin type A injection can improve overall response to botulinum toxin. |
### Instruction:
Does prevention of autoimmune gastritis in mice require extra-thymic T-cell deletion and suppression by regulatory T cells?
### Response:
| Prevention of autoimmune gastritis requires the extra-thymic purging of highly autoaggressive H(+)/K(+) ATPase-specific T cells to produce a T-cell repertoire that is more susceptible to the suppressive activity of regulatory T cells. Taken together with recent published data describing the role of T-cell receptor sign... |
### Instruction:
Is qT peak prolongation associated with left ventricular hypertrophy in teenage professional football players?
### Response:
| QT peak interval, which is associated with pathological LVH in hypertensive patients and is a measure of risk of cardiac death, does not correlate with LVH characterized by myocyte hypertrophy in young apparently healthy professional footballers. |
### Instruction:
Do why patients with lung cancer want help with some needs?
### Response:
| Patients with lung cancer may have a number of supportive care concerns, but they do not always ask for help with those issues. Some patients may be unaware of possible help, and others may not want help from professionals. Supportive care needs must be identified quickly and effectively so that appropriate interventio... |
### Instruction:
Do elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence?
### Response:
| Elevated CD133 mRNA levels at >or=4.79 predicted colon cancer recurrence independent of TNM stage IV disease. Larger prospective studies comparing the current assay with standardized methodology are warranted. |
### Instruction:
Are aDAMTS-4 and -8 inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques?
### Response:
| The present study suggests that ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of atherosclerotic plaques. This is the first study associating ADAMTS-4 and -8 expression with atherosclerosis. However, further experiments are required to understand the physiological and pathologica... |
### Instruction:
Do heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction?
### Response:
| Adrenal alpha(2)-mediated feedback regulation of epinephrine secretion differs fundamentally from sympathetic feedback control. A single adrenoceptor subtype, alpha(2C), operates without a significant receptor reserve to prevent elevation of circulating epinephrine levels. This genetic model may provide an experimental... |
### Instruction:
Does beclin 1-mediated macroautophagy involve regulation of caspase-9 expression in cervical cancer HeLa cells?
### Response:
| siRNA against Beclin 1 transfectants promoted the cell proliferation but overexpression of Beclin 1 promoted the autophagy cell death, and in the process of autophagy triggered by Beclin 1 expression followed accordingly the regulation of the expression of caspase-9. We conjecture that the autophagy gene Beclin 1 may b... |
### Instruction:
Is c-reactive protein a prognostic parameter in patients with cervical cancer?
### Response:
| CRP serum levels can be used as additional prognostic parameter in patients with cervical cancer. |
### Instruction:
Is a single binding motif required for SPAK activation of the Na-K-2Cl cotransporter?
### Response:
| We demonstrate that physical docking of SPAK to NKCC1 is necessary for cotransporter activity under both baseline and hyperosmotic conditions. We identify T(206) and T(211) as major phospho-acceptor sites involved in cotransporter function, with T(206) common to two separate regulatory pathways: one involving SPAK, the... |
### Instruction:
Does sitting position alter minimum alveolar concentration for desflurane?
### Response:
| The sitting position does not change desflurane anesthetic requirements for immobility. |
### Instruction:
Do changes in speech production in an early deafened adult with a cochlear implant?
### Response:
| These results were discussed in relation to how long-term reduction of general auditory input and under-use of the speech production mechanisms can be remediated by technological and behavioural treatment. |
### Instruction:
Is abdominal ultrasound an unreliable modality for the detection of hemoperitoneum in patients with pelvic fracture?
### Response:
| A FAST examination with negative result does not aid in determining the need for laparotomy versus pelvic angiography in patients with pelvic fracture at risk for hemorrhage. These patients should undergo additional confirmatory evaluation to exclude intraperitoneal hemorrhage. |
### Instruction:
Is increased bone marrow iron stores an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation?
### Response:
| The prospective validation of BMIS for risk stratification in patients with leukemia or those who undergo allogeneic hematopoietic stem cell transplantation is needed. |
### Instruction:
Does the combination of chemotherapy and intraperitoneal MegaFas Ligand improve treatment of ovarian carcinoma?
### Response:
| MFL is a novel pro-apoptotic molecule that is able to efficiently induce apoptosis in ovarian cancer cells as well as to potentiate the activity of chemotherapeutic agents in vitro and in vivo. |
### Instruction:
Do mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease?
### Response:
| Variants in innate immune receptor genes were found to influence antibody formation against microbial epitopes. In this respect, it is intriguing that an opposite effect of CARD15 and TLR4 variants was observed. These findings may contribute to an understanding of the aetiology of the seroreactivity observed in IBD. |
### Instruction:
Is up-regulation of cPLA ( 2 ) gene expression in astrocytes by all three conventional anti-bipolar drugs drug-specific and enzyme-specific?
### Response:
| Both up- and down-regulation of cPLA(2) gene expression are involved in the mechanisms of action of anti-bipolar drugs; astrocytes are a target for these drugs. |
### Instruction:
Is elevated HDL cholesterol a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene?
### Response:
| Increased HDL cholesterol levels caused by mutations in CETP are associated with an increased risk of ischemic heart disease in white women. |
### Instruction:
Is interferon treatment associated with a worsening of psychiatric symptoms in patients with hepatitis C?
### Response:
| The risk of serious psychiatric symptoms when being treated with interferon-alpha may not be high. Psychiatric illness or the possibility of psychiatric complications should not be used as a reason to refuse this treatment to patients with hepatitis C. |
### Instruction:
Is raised plasminogen activator inhibitor-1 ( PAI-1 ) an independent risk factor in the polycystic ovary syndrome ( PCOS )?
### Response:
| Plasminogen activator inhibitor-1 activity is not raised in women with PCOS independent of obesity and these results do not support the hypothesis that it may contribute to their anovulatory infertility, or increase their risk of thrombosis. The only significant metabolic features of the PCOS independent of obesity are... |
### Instruction:
Is production of tissue inhibitor of metalloproteinases 3 selectively enhanced by calcium pentosan polysulfate in human rheumatoid synovial fibroblasts?
### Response:
| The present study is the first to demonstrate that the new antiarthritic drug, CaPPS, selectively enhanced TIMP-3 production at the posttranscription level in cultured rheumatoid synovial fibroblasts and in the lining cells of rheumatoid synovium. By this mechanism, CaPPS may be able to modulate joint tissue destructio... |
### Instruction:
Is the omeprazole test as sensitive as 24-h oesophageal pH monitoring in diagnosing gastro-oesophageal reflux disease in symptomatic patients with erosive oesophagitis?
### Response:
| In this study an omeprazole test was at least as sensitive as ambulatory 24-h oesophageal pH monitoring in diagnosing GERD in patients with erosive oesophagitis. |
### Instruction:
Are congenital anomalies an independent risk factor for neonatal morbidity and perinatal mortality in preterm birth?
### Response:
| Congenital anomalies in preterm birth are associated with a higher rate of pregnancy complications and are an independent risk factor for neonatal morbidity and perinatal mortality. |
### Instruction:
Does matrix metalloproteinase-2 contribute to ischemia-reperfusion injury in the heart?
### Response:
| These results show that acute release of MMP-2 during reperfusion after ischemia contributes to cardiac mechanical dysfunction. The inhibition of MMPs may be a novel pharmacological strategy for the treatment of ischemia-reperfusion injury. |
### Instruction:
Does topiramate modulate GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism?
### Response:
| These results indicate that GABA(A)-receptor sensitivity to TPM is not dependent on the presence of BZD sensitivity. Enhancement of GABA-mediated inhibition through a BZD-insensitive pathway may represent one mechanism through which TPM exerts its anticonvulsant action. |
### Instruction:
Is excess mortality associated with increased pulse pressure among middle-aged men and women explained by high systolic blood pressure?
### Response:
| Increasing pulse pressure is a predictor of death from coronary heart disease, stroke, cardiovascular disease and all causes in men and women aged 45-64 years, but the increase in risk is entirely associated with the increase in systolic blood pressure. |
### Instruction:
Does early angiotensin converting enzyme inhibitor therapy enhance the benefits of late coronary artery reperfusion on infarct expansion?
### Response:
| Early post-myocardial infarction ACE inhibitor treatment enhances the benefits of late coronary reperfusion on infarct expansion. The benefits may be related to hypertrophy of still-viable myocytes within the infarcted zone. |
### Instruction:
Is cluster headache associated with signs of a systemic inflammation?
### Response:
| These results were taken as evidence that no systemic inflammation is present during the active cluster headache period. However, whether a local retro-orbital inflammation underlies the pathophysiology of cluster headache remains obscure. |
### Instruction:
Do antiprothrombin and antiannexin V antibodies imply risk of thrombosis in patients with systemic autoimmune diseases?
### Response:
| Measurement of aPT and aANX antibodies may be of value in confirming the diagnosis of APS, and in evaluating risk of venous and arterial thrombosis in patients with systemic autoimmune diseases. |
### Instruction:
Are high serum levels of pro-matrix metalloproteinase-3 associated with greater radiographic damage and the presence of the shared epitope in patients with rheumatoid arthritis?
### Response:
| Our data indicate that there is a significant relationship between radiographic damage and serum levels of proMMP-3. As well, higher circulating levels of proMMP-3 are found in patients positive for the SE, particularly in early RA, and this may partly explain the association between the SE and more erosive disease. |
### Instruction:
Does one year growth hormone replacement therapy alter colonic epithelial cell proliferation in growth hormone deficient adults?
### Response:
| Six to 12 months of GH replacement therapy, aimed to increase plasma IGF-I into the (high) physiological range, does not adversely affect colonic epithelial cell proliferation as a biomarker for the risk of development of colorectal cancer. |
### Instruction:
Does retinoic acid suppress interleukin-6 production in human endometrial cells?
### Response:
| Retinoids may play a fundamental role in altering the pathophysiology of endometriosis related to aberrant production of IL-6. |
### Instruction:
Do tubeless combined high-frequency jet ventilation for laryngotracheal laser surgery in paediatric anaesthesia?
### Response:
| The application of the combined double frequency HFJV was effective in maintaining gas exchange in the presence of laryngeal or tracheal stenoses. It provided good visibility of anatomical structures and offered space for surgical manipulation, avoiding the use of combustible material inside the larynx or trachea. |
### Instruction:
Is fetal sciatic nerve growth delayed following repeated maternal injections of corticosteroid in sheep?
### Response:
| Repeated prenatal corticosteroids have the capacity to affect the growth of peripheral nerve axons in sheep. Documentation of their effects in human pregnancy await randomized trials. |
### Instruction:
Is headache in patients with mild to moderate hypertension generally not associated with simultaneous blood pressure elevation?
### Response:
| Our results did not support the opinion that headache experienced by stage 1-2 hypertensives was generally caused by simultaneous elevation in blood pressure. The direct mechanisms of headache in hypertension, as well as the relation between increments in blood pressure above 180/110 mmHg and headache, need further inv... |
### Instruction:
Does [ Frequency and costs of hospital stay for hypoglycemia in France in 1995 ]?
### Response:
| Mean unit cost for hospital stays for hypoglycemia is high. Based on the 1993 SESI survey, the probable annual cost for the society for hospital care of patients with hypoglycemia was an estimated 108 to 151 million FF ($16-22 million) in 1995. This figure only takes into account the visible cost of caring for hypoglyc... |
### Instruction:
Is lipoprotein ( a ) a risk factor for occurrence of acute myocardial infarction in patients with coronary vasospasm?
### Response:
| Elevated serum level of Lp(a) was found to be associated with a history of prior MI in patients with coronary spasm, suggesting that Lp(a) may play an important role in the genesis of thrombotic coronary occlusion and the occurrence of AMI subsequent to coronary spasm. |
### Instruction:
Does a human homologue of yeast anti-silencing factor have histone chaperone activity?
### Response:
| These results show that human CIA, whose yeast homologue ASF1 is an anti-silencing factor, possesses histone chaperone activity. This leads to a better understanding of the relationship between chromatin structural changes and anti-silencing processes. |
### Instruction:
Does atrial fibrillation independently prolong hospital stay after coronary artery bypass surgery?
### Response:
| Atrial fibrillation lengthens hospital stay after CABG, and its effect is independent of other important variables. Identification of patients who are at risk for AF and successful treatment to prevent AF will likely contribute to major reductions in consumption of health care resources in patients with CABG. |
### Instruction:
Does preoperative high dose methylprednisolone attenuate the cerebral response to deep hypothermic circulatory arrest?
### Response:
| Treatment with high dose methylprednisolone at 8 and 2 h preoperatively attenuates the normal cerebral response to a period of deep hypothermic ischaemia. This technique may therefore offer a safe and inexpensive strategy for cerebral protection during repair of congenital heart defects with the use of DHCA. |
### Instruction:
Does major trauma enhance store-operated calcium influx in human neutrophils?
### Response:
| SOCI may play an important role in PMN activation, and trauma increases PMN SOCI. Prolonged elevations of [Ca2+]i due to enhanced SOCI may alter stimulus-response coupling to chemotaxins and contribute to PMN dysfunction after injury. |
### Instruction:
Does interfraction interval affect survival of patients with non-small cell lung cancer treated with chemotherapy and/or hyperfractionated radiotherapy : a multivariate analysis of 1076 RTOG patients?
### Response:
| Length of IFI (4-6 h vs. 6-8 h) did not influence survival and acute complications incidence in pts with NSCLC treated in RTOG studies with HFX-RT to 69.6 Gy. Previously identified factors, such as use of CT, minimal weight loss, good KPS and low nodal stage, were confirmed again to be associated with a favorable progn... |
### Instruction:
Does mechanical stress induce the expression of high molecular mass heat shock protein in human chondrocytic cell line CS-OKB?
### Response:
| Mechanical stress induces the expression of a high molecular mass heat shock protein corresponding to SIC 1 in human chondrocytic cells. SIC 1 may play an important role in the mechanical stress-responded metabolism of human chondrocytes. |
### Instruction:
Does osteogenic protein-1 promote the synthesis and retention of extracellular matrix within bovine articular cartilage and chondrocyte cultures?
### Response:
| These results demonstrate that osteogenic protein-1 stimulates not only the synthesis of the major cartilage extracellular matrix component aggrecan, but also two associated molecules necessary for the retention of aggrecan, namely hyaluronan and CD44. |
### Instruction:
Do patients ' perceptions of physicians ' recommendations for comfort care differ by patient age and gender?
### Response:
| Among patients with advanced illness, perceived comfort care recommendations were related to patient age and gender, raising concern about possible gender and age bias in physicians' recommendations. Although all patients and proxies gave significant decision-making authority to physicians, older individuals were more ... |
### Instruction:
Is c-met tyrosine kinase receptor expression associated with abnormal beta-catenin expression and favourable prognostic factors in invasive breast carcinoma?
### Response:
| c-met immunohistochemical expression seems to be associated with abnormal beta-catenin expression, good prognostic and predictive factors and favourable outcome in breast cancer patients. |
### Instruction:
Are hot spot microvessel density and the mitotic activity index strong additional prognostic indicators in invasive breast cancer?
### Response:
| These data suggest that the hot spot MVD in four fields of vision is a major independent prognostic factor for overall survival in invasive breast cancer. For the first time, it is shown that hot spot MVD provides additional prognostic information to well established factors like lymph node status and the MAI, and may ... |
### Instruction:
Does overexpression of 27-kDa heat shock protein relate to poor histological differentiation in human oesophageal squamous cell carcinoma?
### Response:
| In human oesophagus, HSP27 expression is induced by various stresses but alcohol and tobacco generate focal perturbations in the stress response. Tumour immunoreactivity for this protein increases with the anaplasia of the tumour, as in some other tumours in which it is considered to play a role in drug resistance. To ... |
### Instruction:
Is synovial hyperplasia in HTLV-I associated arthropathy induced by tumor necrosis factor-alpha produced by HTLV-I infected CD68+ cells?
### Response:
| Our results suggest HTLV-I viral tropism for CD68+ cells, and that HTLV-I infected synoviocytes were induced to produce TNF-alpha, which enhances synovial proliferation in HAAP. |
### Instruction:
Does bucillamine suppress human Th1 cell development by a hydrogen peroxide-independent mechanism?
### Response:
| Bucillamine directly acts on CD4+CD45RO- T cells to suppress Th1 cell development by a hydrogen peroxide-independent mechanism. This previously unknown action may explain the in vivo effect of bucillamine in the treatment of rheumatoid arthritis. |
### Instruction:
Do seasonal changes in calcium homeostasis affect the incidence of postoperative tetany in patients with Graves ' disease?
### Response:
| Patients with Graves' disease are more susceptible to calcium and vitamin D deficiency during the winter than during the summer, resulting in the tendency toward a higher incidence of postoperative tetany in winter. |
### Instruction:
Is weight loss correlated with an improved lipoprotein profile in obese postmenopausal women?
### Response:
| Both weight loss and diet modifications are associated with an improved plasma lipid profile in obese postmenopausal women. |
### Instruction:
Does initial response to portoenterostomy determine long-term outcome in patients with biliary atresia?
### Response:
| Portoenterostomy alone in biliary atresia is beneficial in 40% of cases. Factors associated with the outcome include age at operation, postoperative cholangitis, and change in values of bilirubin and alanine transaminase. A classification based on decline of bilirubin and enzyme levels 3 months after portoenterostomy i... |
### Instruction:
Do formulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection?
### Response:
| Through the modulation of various mixture conditions, large-sized lipoplexes can be formed which are resistant to the transfection-inhibiting effect of serum. |
### Instruction:
Does myocardial injury-induced fibroblast proliferation facilitate retroviral-mediated gene transfer to the rat heart in vivo?
### Response:
| Local gene transfer to the healing rat heart is feasible by retrovirus in vivo. This observation may serve as a useful guide for the development of gene therapy aimed at myocardial repair after myocardial infarction. |
### Instruction:
Is exogenous wt-p53 protein active in transformed cells but not in their non-transformed counterparts : implications for cancer gene therapy without tumor targeting?
### Response:
| Non-transformed C2C12 cells present regulatory system(s) which control the expression and the activity of exogenously expressed wt-p53 protein probably through degradation and maintenance in a latent form. This regulatory system is lost/inactivated upon transformation. |
### Instruction:
Is c282Y mutation in the HLA-H gene a risk factor for patients with myocardial infarction?
### Response:
| Our data suggested that the most common cause of iron overload is not associated with myocardial infarction. |
### Instruction:
Do inhibitors present in blood inhibit PCR from buccal cell preparations : case report?
### Response:
| These results suggests that a buccal cell DNA extraction may be useful in cases where blood samples contain inhibitory substances for PCR. |
### Instruction:
Do alterations of preliminary readings on radiographic examinations minimally affect outcomes of trauma patients discharged from the emergency department?
### Response:
| Discharged trauma patients are more likely to harbor alterations of preliminary interpretations than other ED patients. Although the official readings for these trauma patients will occasionally reveal previously undetected pathologic conditions, the majority of such cases can be managed with outpatient follow-up. |
### Instruction:
Is inhibition of neutrophil apoptosis after severe trauma NFkappabeta dependent?
### Response:
| NFkappabeta-dependent inhibition of neutrophil apoptosis occurs after trauma. Early inhibition of PMN apoptosis is dependent on the magnitude of injury. |
### Instruction:
Does nISS predict postinjury multiple organ failure better than the ISS?
### Response:
| The NISS is superior to the ISS in the prediction of postinjury MOF. This measure of tissue injury severity should replace the ISS in trauma research. |
### Instruction:
Does tissue plasminogen activator inhibit reactive oxygen species production by macrophages?
### Response:
| Our results suggest that tPA has broad inhibitory effects on inflammatory cell ROS production. In diseases such as atherosclerosis and acute respiratory distress syndrome, these data suggest the possible utility of exogenous tPA as an antiinflammatory agent and a physiologic role for endogenous tPA that goes beyond mai... |
### Instruction:
Is fat tissue accumulation during peritoneal dialysis associated with a polymorphism in uncoupling protein 2?
### Response:
| As most patients with the deletion/deletion UCP2 genotype acquired fat tissue during PD, the present results suggest that the UCP2 polymorphism contributes to variations in body composition. Thus, variations in UCP2 production or activity may be factors contributing to adipose tissue accumulation in a subgroup of patie... |
### Instruction:
Does ethanol improve decreased filterability of human red blood cells through modulation of intracellular signaling pathways?
### Response:
| The present results suggest a beneficial effect of ethanol on blood rheology at concentrations that are physiologically achievable in the blood and indicate the importance of intracellular signaling pathways in regulating the deformability of RBCs. |
### Instruction:
Does cTLA-4 gene polymorphism confer susceptibility to primary biliary cirrhosis?
### Response:
| The CTLA-4 exon 1 polymorphism is the first non-major histocompatibility complex gene to be identified as a susceptibility locus for PBC. Our data support the hypothesis that clinically distinct autoimmune disease may be controlled by a common set of susceptibility genes. |
### Instruction:
Does two-month glucocorticoid treatment increase proliferation in the stomach and large intestine of rats?
### Response:
| As opposed to treatments for 3 or 33 days, glucocorticoid treatment for 2 months leads to an increase in the number of cycling cells in the gastric and colonic mucosae. |
### Instruction:
Does percentage of glycosylated serum ferritin remain low throughout the course of adult onset Still 's disease?
### Response:
| Total serum ferritin is a marker of the active phase of AOSD. The percentage of glycosylated ferritin is low both in the active phase and in remission. Further studies are needed to confirm these data and to determine their specificity for AOSD before considering any possible use of a low percentage of glycosylated fer... |
### Instruction:
Does clonidine provide an allergy-free alternative in glaucoma patients with proven allergy to apraclonidine?
### Response:
| Clonidine did not cause allergic reaction in patients with proven allergy to apraclonidine, indicating that there is no cross-reactivity with apraclonidine. Due to the small series, however, we cannot assume that allergy will not occur with clonidine 0.25% given time and a larger number of patients. |
### Instruction:
Do acupressure wristbands prevent postoperative nausea and vomiting after urological endoscopic surgery?
### Response:
| Application of acupressure wristbands at the P6 of both forearms 30 min before induction of anesthesia did not decrease the incidence of PONV in patients undergoing endoscopic urological procedures. |
### Instruction:
Does peroperative titration of morphine improve immediate postoperative analgesia after total hip arthroplasty?
### Response:
| This study demonstrated that the peroperative administration of morphine can facilitate immediate postoperative pain management. |
### Instruction:
Does therapeutic immunoadsorption increase the level of circulating soluble HLA molecules?
### Response:
| The significant increase in sHLA-DR may contribute to the immunomodulatory effect of IA. |
### Instruction:
Does extracorporeal plateletpheresis induce the interaction of activated platelets with white blood cells?
### Response:
| This study demonstrates that platelets become activated during apheresis and that following this process, interaction with monocytes and neutrophilic granulocytes occurs. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.