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### Instruction:
Does fluid accumulation within the uterine cavity reduce pregnancy rates in women undergoing IVF?
### Response:
| Fluid accumulation within the uterine cavity during the IVF transfer treatment could be observed in patients with both tubal and non-tubal factors; however, it mainly occurred in women with tubal infertility. Although it is not a common complication of IVF cycles, excessive uterine fluid is detrimental to embryo implan... |
### Instruction:
Does paclitaxel trigger cell death primarily via caspase-independent routes in the non-small cell lung cancer cell line NCI-H460?
### Response:
| Paclitaxel triggers cell death in H460 cells mainly via a currently unidentified caspase-independent mechanism in which the basic apoptotic machinery is merely coactivated. This finding is in sharp contrast with the largely caspase-dependent response elicited by DNA-damaging agents in these cells. We speculate on thera... |
### Instruction:
Are substance P and neurokinin levels decreased in the cortex and hypothalamus of alcohol-preferring ( P ) rats?
### Response:
| These data indicate that endogenous SP and neurokinin levels are reduced in discrete brain regions of P rats compared with NP rats. These decreases may be associated with decreased serotonergic innervation of these brain regions in P rats compared with NP rats. |
### Instruction:
Does clomipramine increase the striatal concentrations of dopamine and homovanillic acid in rats chronically consuming alcohol?
### Response:
| These findings show that clomipramine produces favorable changes in dopaminergic systems altered by chronic alcohol administration. Results also provide evidence to support further prospective studies of potential therapeutic effects of antidepressant drugs in alcoholism. |
### Instruction:
Are serum S100B protein levels correlated with subclinical neurocognitive declines after carotid endarterectomy?
### Response:
| These data suggest that subtle cerebral injuries after CEA, even in the absence of overt strokes, are associated with significant increases in serum S100B but not neuron-specific enolase levels. Analyses of earlier time points in future studies of subtle cognitive injuries and biochemical markers of cerebral injury aft... |
### Instruction:
Does conditioning hypoxia in vivo alter neuronal excitability of hippocampal neurones of rats in vitro and in vivo?
### Response:
| lt. may be hypothesized that elevated Ca++ transport in the neurons during conditioning hypoxia is responsible for both long- lasting increases in plastic reactions and the protective effect. |
### Instruction:
Does 17beta-estradiol increase rat cerebrovascular prostacyclin synthesis by elevating cyclooxygenase-1 and prostacyclin synthase?
### Response:
| Our findings suggest that estrogen influences the biosynthesis of prostacyclin, which may be important in the regulation of cerebral blood flow and thrombosis. This finding may shed light on the mechanisms that govern sex-based differences in cerebrovascular disease. |
### Instruction:
Is inhibition of factor IX ( a ) protective in a rat model of thromboembolic stroke?
### Response:
| The data indicate that the inhibition of factor IX(a) within 4 hours of thromboembolic stroke produced a more favorable outcome than tPA. When treatment was initiated 6 hours after stroke, the benefits of factor IX(a) inhibition were lost, whereas tPA continued to suppress lesion development, albeit without a correspon... |
### Instruction:
Do selectins mediate macrophage infiltration in obstructive nephropathy in newborn mice?
### Response:
| Following UUO, selectins mediate macrophage infiltration into the obstructed kidney, which in turn may induce tubular apoptosis, tubular atrophy and interstitial fibrosis. |
### Instruction:
Does indomethacin protect permeability barrier from focal segmental glomerulosclerosis serum?
### Response:
| These studies implicate a product of the cyclooxygenase pathway of arachidonic acid metabolism as mediating the increased Palb caused by FSGS serum in our in vitro assay and possibly the proteinuria seen in patients with FSGS. |
### Instruction:
Do effects of oxalate on the re-initiation of DNA synthesis in LLC-PK1 cells involve p42/44 MAP kinase activation?
### Response:
| These findings demonstrate that oxalate does not activate the p42/44 MAP kinase pathway, and the effects of oxalate are mediated by pathways that are distinct from those of EGF, PDGF and insulin. |
### Instruction:
Is the abdominal compartment syndrome a morbid complication of postinjury damage control surgery?
### Response:
| ACS after postinjury DCS worsens outcome. With the exception of early elevation in peak airway pressure, we could not identify patients at higher risk for ACS; moreover, preemptive abdominal bag closure during initial DCS did not prevent this highly morbid complication. |
### Instruction:
Does tumor hypoxia have independent predictor impact only in patients with node-negative cervix cancer?
### Response:
| Tumor hypoxia is an independent predictor of poor PFS only in patients with node-negative cervix cancer, in addition to tumor size. Its impact appears to be related to an increased risk of distant metastases rather than to an effect on pelvic control. |
### Instruction:
Does [ Request of dental care and periodontal treatment need in a population sample of Palermo ]?
### Response:
| These findings showed that the awareness of periodontal diseases by the population examined is poor. This could be due either to the lack or failure of public education programmes on periodontal health. Yet, it could be related to an inadequate dentists' awareness of the periodontal diseases. Such findings should be co... |
### Instruction:
Does notch signaling control cell fate specification along the dorsoventral axis of the Drosophila gut?
### Response:
| Our results demonstrate that Notch signaling plays a pivotal role in determining cell fates along the DV axis of the Drosophila hindgut. The finding that Notch signaling results in the expression of an apical polarity organizer which may be required, in turn, for apical Notch receptor localization suggests a simple mec... |
### Instruction:
Does contactin support synaptic plasticity associated with hippocampal long-term depression but not potentiation?
### Response:
| These results indicate that contactin plays a selective role in synaptic plasticity and identify PPF and LTD, but not LTP, as contactin-dependent processes. Engagement of the contactin-Caspr complex with RPTPbeta may thus regulate cell-cell interactions contributing to specific synaptic plasticity forms. |
### Instruction:
Do [ Nonperforating trabecular surgery with reticulated hyaluronic acid implant ]?
### Response:
| The elevated IOP in patients with open angle glaucoma can be effectively reduced by NPTS, and the number of drugs used for anti-glaucoma was decreased. The post-operative complications were much less because of no intra-operative penetration of the anterior chamber. Therefore, NPTS is a very hopeful and practicable new... |
### Instruction:
Does fat mass measured by DXA vary with scan velocity?
### Response:
| Scan velocity significantly influences the measured fat mass size, lean body mass, bone mineral content, and body weight. To obtain the most accurate results, slow mode is preferable and fast scans should be avoided. Future studies should report and take scan velocity into consideration. |
### Instruction:
Does apoE deficiency compromise the blood brain barrier especially after injury?
### Response:
| Our results show that the combination of loss of apoE function with high plasma cholesterol and especially brain injury results in dramatic BBB defects in the cortex and may explain in part the importance of apoE in Alzheimer's disease and in successful recovery from brain injury. |
### Instruction:
Is daytime sleepiness associated with 3-year incident dementia and cognitive decline in older Japanese-American men?
### Response:
| Daytime sleepiness in older adults may be an early indicator of decline in cognitive functioning and onset of dementia. |
### Instruction:
Is corneal stimulation of MMP-1 , -9 and uPA by platelet-activating factor mediated by cyclooxygenase-2 metabolites?
### Response:
| During corneal injury and inflamation, PAF is an important factor in the activation of proteolytic cascades, which could lead to corneal epithelial defects and ultimately ulceration. One important goal in treating these defects is to modulate the activity of enzymes that destroy the extracellular matrix. Our results su... |
### Instruction:
Do high concentrations of glucose induce synthesis of argpyrimidine in retinal endothelial cells?
### Response:
| These results suggest that MG-mediated protein modification can occur in elevated glucose, and might contribute to endothelial cell changes associated with diabetic retinopathy. |
### Instruction:
Does the symbiosis of Bacillus subtilis L-forms with Chinese cabbage seedlings inhibit conidial germination of Botrytis cinerea?
### Response:
| Symbiosis of B. subtilis L-form bacteria during seed germination of Chinese cabbage inhibits conidial germination in plants on subsequent exposure to Botrytis cinerea. |
### Instruction:
Does resistance training preserve skeletal muscle function during unloading in humans?
### Response:
| These results indicate that a resistance-training paradigm employed every third day during 21 d of unloading was effective in maintaining skeletal muscle strength (static and dynamic) and size of the KE and PF. |
### Instruction:
Do mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones?
### Response:
| The viscosity of gallbladder bile is markedly higher than that of hepatic bile in patients with gallstones. The concentration of mucin is the major determinant of biliary viscosity and may contribute by this mechanism to the role of mucin in the pathogenesis of gallstones. |
### Instruction:
Does rotational atherectomy reduce recurrent in-stent restenosis : results of the angioplasty versus rotational atherectomy for treatment of diffuse in-stent restenosis trial ( ARTIST )?
### Response:
| In terms of the primary objective of the study, PTCA produced a significantly better long-term outcome than ROTA followed by adjunctive low-pressure PTCA. |
### Instruction:
Does angiotensin II type 1 receptor blockade ameliorate tubulointerstitial injury induced by chronic potassium deficiency?
### Response:
| These results indicate that hypokalemic renal injury is mediated, at least in part, by Ang II via the Ang II type 1 receptor, with a lesser contribution mediated by a reduction in nitric oxide. Losartan may be beneficial in preventing hypokalemic tubulointerstitial injury. |
### Instruction:
Does pyridoxamine inhibit early renal disease and dyslipidemia in the streptozotocin-diabetic rat?
### Response:
| Pyridoxamine inhibits the progression of renal disease, and decreases hyperlipidemia and apparent redox imbalances in diabetic rats. Pyridoxamine and aminoguanidine had similar effects on parameters measured, supporting a mechanism of action involving AGE/ALE inhibition. |
### Instruction:
Is transthoracic echocardiography cost-effective in critically ill surgical patients?
### Response:
| The routine use of TTE to initially evaluate all critically ill surgical patients who require echocardiography should be abandoned because it is not cost-effective. TEE appears to be the most cost-effective echocardiographic modality in the surgical intensive care unit. |
### Instruction:
Is the sensitivity of digestive tract tumor cells to As2O3 associated with the inherent cellular level of reactive oxygen species?
### Response:
| The cellular sensitivity to apoptosis induced by As2O3 is associated with the difference in cellular ROS level. The inherent ROS level might determinate the apoptotic sensitivity of tumor cells to As2O3. |
### Instruction:
Does rRR-alpha-tocopheryl succinate inhibit human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest?
### Response:
| VES can inhibit human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest. Inhibition of SGC-7901 cell growth by VES is dose- and time-dependent. Therefore VES can function as a potent chemotherapeutic agent against human gastric carcinogenesis. |
### Instruction:
Does vEGF165 antisense RNA suppress oncogenic properties of human esophageal squamous cell carcinoma?
### Response:
| The angiogenesis and tumorigenicity of human esophageal squamous cell carcinoma were effectively inhibited by VEGF165 antisense RNA. Antisense RNA to VEGF165 can potentially be used as an adjuvant therapy for solid tumors. |
### Instruction:
Does [ Dietary fiber protect intestinal structure and barrier function ]?
### Response:
| The dietary fiber protects the intestinal structure and barrier function of 5-Fu challenged rats. |
### Instruction:
Do association of elevated glial expression of interleukin-1beta with improved survival in patients with glioblastomas multiforme?
### Response:
| Taken together, these data indicate that the proinflammatory cytokine IL-1beta produced within GBM by glial-derived cells has a negative impact on tumor growth through a mechanism independent of iNOS induction. |
### Instruction:
Is gastric permeability increased in children colonized by CagA-positive strains of Helicobacter pylori?
### Response:
| These results indicate that in Chile, about 60% of the Helicobacter pylori infected children are colonized by CagA-positive strains, in association with more intense lesions of the gastric mucosa, but that gastric permeability to sucrose does not discriminate between colonization by CagA-negative and positive strains o... |
### Instruction:
Are relatively high risk of treatment failure after prostatectomy : tumour grade , histopathological stage and the preoperative serum PSA level key prognosticators?
### Response:
| Our study indicates, that the risk of treatment failure depends strongly on the grade of the tumour and increases when preoperative PSA value is greater than l0 ng/ml. |
### Instruction:
Does tolbutamide alter glucose transport and metabolism in the embryonic mouse heart?
### Response:
| Tolbutamide stimulates glucose uptake and metabolism in the embryonic heart, as occurs in adult extra-pancreatic tissues. Glut-1 and HKI, but not GRP78, are likely involved in tolbutamide-induced cardiac dysmorphogenesis. |
### Instruction:
Is thyroid transcription factor-1 highly sensitive and specific in differentiating metastatic pulmonary from extrapulmonary adenocarcinoma in effusion fluid cytology specimens?
### Response:
| The current study validates TTF-1 as a highly sensitive and specific immunomarker for distinguishing between metastatic pulmonary and extrapulmonary adenocarcinoma in effusion cytology specimens, which are known to be associated with intrinsic artifact due to less than ideal cellular preservation. |
### Instruction:
Is cortisol-binding globulin important in the interpretation of dynamic tests of the hypothalamic -- pituitary -- adrenal axis?
### Response:
| CBG varies significantly within and between individuals. This is accompanied by changes in serum total cortisol large enough to affect the outcome of an SST and, by implication, other tests of the HPA axis. |
### Instruction:
Does postnatal endotoxin exposure result in increased insulin sensitivity and altered activity of neuroendocrine axes in adult female rats?
### Response:
| The results indicate that postnatal exposure to LPS leads to increased insulin sensitivity in the adult female rat. In addition, LPS-treated rats showed changes in the regulation of hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes. This study suggests that postnatal exposure to an endotoxin such a... |
### Instruction:
Does impairment of vascular regeneration precede progressive glomerulosclerosis in anti-Thy 1 glomerulonephritis?
### Response:
| Progressive glomerulosclerosis can be induced in the rat by a one shot injection of anti-Thy 1.1 monoclonal antibody followed by unilateral nephrectomy. This model shows that there is a positive association between impairment of vascular regeneration and the development of glomerulosclerosis. |
### Instruction:
Does addition of AT1 blocker fail to overcome resistance to ACE inhibition in adriamycin nephrosis?
### Response:
| ACE inhibition has variable renal protective efficacy in the adriamycin model. Neither increasing the dose of the ACE inhibitor beyond the optimal level nor co-treatment with AII-A overcome the individual therapy resistance. Thus, in established adriamycin nephrosis, blockade of the renin-angiotensin system at two diff... |
### Instruction:
Do human renal epithelial cells express iNOS in response to cytokines but not bacteria?
### Response:
| We conclude that uropathogenic E. coli that attach to HRTEC fail to directly activate iNOS expression, and that iNOS expression during bacterial infection is more likely to result from stimulation by local cytokines such as IL-1beta and IFN-gamma. |
### Instruction:
Do reported adverse food reactions overestimate true food allergy in the community?
### Response:
| There was little agreement between self-reported perceived illness to food(s) known to contain the food allergen of interest, and positive SPT, suggesting that most reactions are not due to IgE mediated food allergy. |
### Instruction:
Do the effects of income inequality and income level on mortality vary by population size in Texas counties?
### Response:
| This study provides some support for the predictions of Wilkinson's theory. |
### Instruction:
Does vacuum-assisted wound closure provide early fascial reapproximation in trauma patients with open abdomens?
### Response:
| Use of VAWC can safely achieve early fascial closure in more than 90% of trauma patients with open abdomens. |
### Instruction:
Does early postoperative enteral feeding increase anastomotic strength in a peritonitis model?
### Response:
| These data suggest that immediate postoperative feeding results in a beneficial change in the cytokine profile. |
### Instruction:
Does vagal stimulation rapidly increase leptin secretion in human stomach?
### Response:
| Vagal stimulation of leptin release in the human stomach suggests that leptin is released during the cephalic phase of gastric secretion. Luminal leptin may be involved in vagus-mediated intestinal functions. |
### Instruction:
Does acid exposure activate the mitogen-activated protein kinase pathways in Barrett 's esophagus?
### Response:
| Acid increases proliferation and survival, and decreases apoptosis in SEG-1 cells by activating the MAPK pathways. Acid also activates the MAPK pathways in BE in vivo. These findings suggest that acid might contribute to carcinogenesis in BE through activation of MAPK pathways. |
### Instruction:
Do opioid agonists inhibit excitatory neurotransmission in ganglia and at the neuromuscular junction in Guinea pig gallbladder?
### Response:
| These results show that opiates can cause presynaptic inhibition of excitatory neurotransmission at 2 sites within the wall of the gallbladder: vagal preganglionic terminals in ganglia and neuromuscular nerve terminals. These findings support the concept that opiates can contribute to gallbladder stasis by inhibiting g... |
### Instruction:
Does chronic ET ( A ) receptor blockade prevent endothelial dysfunction of small arteries in apolipoprotein E-deficient mice?
### Response:
| Severe hypercholesterolemia in apoE-deficient mice is associated with attenuation of NO-mediated relaxation to acetylcholine and increased vascular endothelin-1 content. Chronic ET(A) receptor blockade may provide a new therapeutic approach to improve NO-mediated endothelium-dependent vasomotion in small arteries. |
### Instruction:
Does cytosolic free magnesium modulate Na/Ca exchange currents in pig myocytes?
### Response:
| Cytosolic free magnesium modulates the I(NCX) over a physiologic range independent of [ATP](i). Reduced [Mg(2+)](i) in heart failure could contribute to altered calcium regulation of the NCX, contributing to the altered heart failure phenotype through enhanced NCX activity. |
### Instruction:
Do high plasma concentrations of human urotensin II alter local or systemic hemodynamics in man?
### Response:
| In contrast to our hypothesised role of hUII, we found no vasoactive responses to hUII in vivo, consistent with recent in vitro studies in human blood vessels, but in contrast to non-human primate studies in vivo. Our data do not support a key role for hUII in the regulation of vascular tone and resting blood pressure ... |
### Instruction:
Do [ Functional reconstruction of mandible by using vascularized fibular free flap and one-stage rehabilitation of the implant ]?
### Response:
| This is a good approach to rehabilitate bone function by using vascularized fibular free flap and one-stage implant placement. |
### Instruction:
Does the immune response to corneal allograft require a site-specific draining lymph node?
### Response:
| The data show that a single specific lymph node, i.e., the SM node, is the major DLN involved in corneal graft rejection whereas its nearest neighbor, the SC DLN, not only cannot substitute for the SM node in priming the immune response but may be involved with the spleen in immune privilege. Retransplantation studies ... |
### Instruction:
Does leukocyte depletion attenuate expression of neutrophil adhesion molecules during cardiopulmonary bypass in human beings?
### Response:
| The major findings of the present study in human subjects undergoing elective cardiac operations with cardiopulmonary bypass are as follows: (1) bypass was associated with an up-regulation of the adhesion molecules L-selectin, CD11b, and CD11c but with no significant change in CD11a expression, and (2) the clinical use... |
### Instruction:
Does free/total PSA ratio improve prediction of pathologic stage and biochemical recurrence after radical prostatectomy?
### Response:
| These results suggest that the F/T PSA ratio is not helpful for the prediction of organ-confined disease and PSA recurrence after radical prostatectomy. |
### Instruction:
Does mild hypothermia induced before cardiac arrest reduce brain edema formation in rats?
### Response:
| Mild hypothermia before CA decreases CA-induced brain edema. The hypothermia-elicited reduction in brain edema does not appear to be neutrophil-dependent and the early brain edema formation may not involve the proteolysis of occludin. |
### Instruction:
Does extracorporeal photopheresis in cutaneous T-cell lymphoma and graft-versus-host disease induce both immediate and progressive apoptotic processes?
### Response:
| The early induction of apoptosis by ECP involves mitochondrial dysfunction, while later apoptosis is associated with the activation of caspases. CD10 expression was very weak and "late", preceded by a strong PS exposure. These apoptotic processes, in vivo, would induce the immediate and progressive phagocytosis of the ... |
### Instruction:
Is secretion of keratinocyte growth factor by cultured human endometrial stromal cells induced through a cyclic adenosine monophosphate-dependent pathway?
### Response:
| These results suggest that a cAMP-dependent pathway may play an important role in the regulation of keratinocyte growth factor production by endometrial stromal cells. Keratinocyte growth factor secreted by endometrial stromal cells may be involved in the regeneration of the endometrium during the normal menstrual cycl... |
### Instruction:
Does angiotensin II infusion ameliorate the early phase of a mesangioproliferative glomerulonephritis?
### Response:
| Ang II surprisingly ameliorates glomerular monocyte infiltration, proliferation and matrix expansion in ATS nephritis. Ang II-mediated induction of cyclin kinase inhibitors and TGF-beta may contribute to the protection of the glomerulus from inflammatory injury by inducing cell cycle arrest and attenuating activation o... |
### Instruction:
Does undetectable postoperative cortisol always predict long-term remission in Cushing 's disease : a single centre audit?
### Response:
| (i) Despite strict criteria for immediate postoperative remission and recurrence, undetectable postoperative cortisol is not always predictive of long-term remission. (ii) Despite an aggressive surgical approach, immediate postoperative remission rates for Cushing's disease are lower compared to other microadenomas. Th... |
### Instruction:
Do men with acromegaly need higher doses of octreotide than women?
### Response:
| The responses to short- and long-acting octreotide illustrate an effect of gender, due to different sensitivity to GH in the periphery. Furthermore, the results show that in the treatment of acromegaly, men will need higher doses of octreotide than women to normalize IGF-1. |
### Instruction:
Does continuous 12-lead ST-segment monitoring improve identification of low-risk patients with chest pain and a worse in-hospital outcome?
### Response:
| In low-risk patients with chest pain, continuous 12-lead ST-segment monitoring provides significant incremental diagnostic and prognostic information to currently used clinical, enzymatic, and ECG data, and is helpful in identifying the subset of patients with a worse in-hospital outcome. |
### Instruction:
Does cardiopulmonary bypass copolymer surface modification reduce neither blood loss nor transfusions in coronary artery surgery?
### Response:
| Our results show that the surface-modified CPB circuit decreased neither blood loss nor transfusions despite slightly better platelet function preservation compared to the unmodified circuit. This type of CPB circuit surface modification does not appear to improve clinical outcome in low-risk coronary artery surgery pa... |
### Instruction:
Is pulmonary blood flow inhomogeneously reduced after Euro Collins-preservation and lung transplantation?
### Response:
| Two separate processes can be observed after single lung transplantation: (1) reduced regional pulmonary blood flow, which is a regional phenomenon restricted to the transplanted organ, and (2) extensive edema affecting both the transplanted and the native lung. |
### Instruction:
Do fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine?
### Response:
| Fruit juices and constituents are more potent inhibitors of OATPs than P-glycoprotein activities, which can reduce oral drug bioavailability. Results support a new model of intestinal drug absorption and mechanism of food-drug interaction. |
### Instruction:
Is stroke associated with coronary calcification as detected by electron-beam CT : the Rotterdam Coronary Calcification Study?
### Response:
| In this population-based study, a markedly graded association was found between coronary calcification and stroke. The results suggest that coronary calcification as detected by electron-beam CT may be useful to identify subjects at high risk of stroke. |
### Instruction:
Does betaine supplementation decrease post-methionine hyperhomocysteinemia in chronic renal failure?
### Response:
| GB supplementation had no effect on fasting tHcy in patients with chronic renal failure who were folate and pyridoxine replete, but it significantly decreased tHcy concentrations after methionine loading. |
### Instruction:
Is white blood cell count associated with some features of metabolic syndrome in a very old population?
### Response:
| The results of this study support the existence of a significant association between WBC count and some of the typical features of metabolic syndrome in very old subjects. |
### Instruction:
Do oral corticosteroids increase esophageal acid contact times in patients with stable asthma?
### Response:
| Prednisone, 60 mg/d for 7 days, increased esophageal acid contact times in this small population of people with stable asthma; however, the mechanism for this finding is unclear. |
### Instruction:
Is secondary abdominal compartment syndrome a highly lethal event?
### Response:
| Secondary ACS may be encountered by general surgeons in a variety of clinical scenarios; resuscitation from severe shock appears to be the critical factor. Early identification and abdominal decompression are essential. Unfortunately, in our experience, this is a highly lethal event. |
### Instruction:
Are mitochondrial injury , oxidative stress , and antioxidant gene expression induced by hepatitis C virus core protein?
### Response:
| Oxidative injury occurs as a direct result of HCV core protein expression both in vitro and in vivo and may involve a direct effect of core protein on mitochondria. These results provide new insight into the pathogenesis of hepatitis C and provide an experimental rationale for investigation of antioxidant therapy. |
### Instruction:
Does nF-kappaB activation in pancreas induce pancreatic and systemic inflammatory response?
### Response:
| Thus, activation of NF-kappaB within the pancreas was sufficient for the initiation of an inflammatory response in this model. These results help define the specific role of NF-kappaB activation in acute pancreatitis. |
### Instruction:
Does iL-10 production in circulating T cells differ between allergen-induced isolated early and dual asthmatic responders?
### Response:
| These results suggest that the contrasting profiles of IL-10 production may be associated with the different time course of allergen-induced airway inflammation between allergen-induced early and dual responders. |
### Instruction:
Does histone deacetylation inhibit IL4 gene expression in T cells?
### Response:
| Our results demonstrate that the acetylation state of histones associated with the IL-4 promoter is a key regulator of IL4 gene expression. |
### Instruction:
Does pollen immunotherapy reduce the development of asthma in children with seasonal rhinoconjunctivitis ( the PAT-study )?
### Response:
| Immunotherapy can reduce the development of asthma in children with seasonal rhinoconjunctivitis. |
### Instruction:
Is a calcium-activated chloride channel ( HCLCA1 ) strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma?
### Response:
| An upregulation of HCLCA1 in the IL-9- responsive mucus-producing epithelium of asthmatic subjects compared with that seen in control subjects supports the hypothesis that this channel may be responsible, in part, for the overproduction of mucus in asthmatic subjects. These preliminary findings suggest the inhibition o... |
### Instruction:
Is the prevalence of antibiotic resistance in bacterial respiratory pathogens from Norway low?
### Response:
| The prevalence of antibiotic resistance in respiratory pathogens in Norway is low. |
### Instruction:
Is catecholamine stimulation associated with impaired myocardial O ( 2 ) utilization in heart failure?
### Response:
| The impairment in contractile responses to dobutamine and norepinephrine in DCM is associated with impaired myocardial O(2) extraction, and a shift toward a preference for glycolysis. A different myocardial metabolic pattern suggestive of increased oxidation of FFA with increased myocardial O(2) extraction was observed... |
### Instruction:
Do hearts from mice lacking desmin have a myopathy with impaired active force generation and unaltered wall compliance?
### Response:
| It is suggested that the intermediate filaments have a role in active force generation of cardiac muscle, possibly by supporting sarcomere alignment or force transmission. The desmin filaments do not contribute the passive elasticity of the ventricle wall. Des-/- mice provide a model for genetic cardiomyopathy where th... |
### Instruction:
Does fibronectin signaling stimulate BNP gene transcription by inhibiting neuron-restrictive silencer element-dependent repression?
### Response:
| These results suggest that Fn-induced BNP up-regulation in rat ventricular myocytes is due to inhibition of NRSE(BNP)-dependent repression of BNP gene transcription. |
### Instruction:
Is conversion of nested reverse-transcriptase polymerase chain reaction from positive to negative status at peripheral blood during androgen ablation therapy associated with long progression-free survival in stage D2 prostate cancer patients?
### Response:
| Our data suggest that conversion to rt-PCR-negative status at PB for PSA and PSMA during objective clinical response to CAB is associated with long progression-free survival in stage D2 disease. |
### Instruction:
Does prevalence and correlate of prostatitis in the health professionals follow-up study cohort?
### Response:
| Self-reported prostatitis was common among healthy men of all ages but there was considerable overlap with self-reported BPH. Prostatitis had several identifiable correlates that may aid in its recognition. |
### Instruction:
Does [ do the type of lens influence stereoscopic vision ]?
### Response:
| All patients with bilateral mono- or different multifocal IOL had good binocular vision in far and near distance including random dot stereopsis. |
### Instruction:
Is telomere erosion independent of microsatellite instability but related to loss of heterozygosity in gastric cancer?
### Response:
| The development of gastric cancer can arise through two different genetic pathways. In high MSI gastric cancers, defective mismatch repair allows mutations to accumulate and generate the high MSI phenotype. In gastric cancers showing either low MSI or MSS, multiple deletions may represent the LOH pathway. Telomere eros... |
### Instruction:
Does [ Hemorrhagic shock increase the occurrence of bacterial translocation ]?
### Response:
| HS increases the occurrence of BT. |
### Instruction:
Do prefrontal lesions impair the implicit and explicit learning of sequences on visuomotor tasks?
### Response:
| The PFC is specifically involved in explicit and implicit motor sequence learning. Different PFC regions may be selectively involved in such learning depending on the cognitive demands of the sequential task. |
### Instruction:
Is pretreatment with topical all-trans-retinoic acid beneficial for wound healing in genetically diabetic mice?
### Response:
| Pretreatment with atRA reversed the impaired wound healing in db/db mice. |
### Instruction:
Does calmodulin inhibitor W-7 unmask a novel electrocardiographic parameter that predicts initiation of torsade de pointes?
### Response:
| Selective suppression of TdP inducibility by W-7, without shortening the duration of cardiac repolarization, allowed identification of the UTA ratio as a new electrocardiographic index for predicting TdP onset. These findings are consistent with the idea that prolonged repolarization is not the proximate cause of arrhy... |
### Instruction:
Is somatotopic organization of the facial nucleus disrupted after lesioning and regeneration of the facial nerve : the histological representation of synkinesis?
### Response:
| Our model provides a clear demonstration of the failure of adult facial nerve axons to make correct connections with their distal targets during regeneration. This model may be used to assess strategies aimed at minimizing synkinesis and, by assessing histology together with behavior, provides a more robust model than ... |
### Instruction:
Do thromboxane synthase inhibitors induce apoptosis in migration-arrested glioma cells?
### Response:
| These data indicate that thromboxane synthase may represent a vortex of divergent signaling cascades that regulate motility and apoptosis in glioma cells. This paradigm may offer a novel perspective in the treatment of patients with malignant gliomas. |
### Instruction:
Is occurrence of extraarticular disease manifestations associated with excess mortality in a community based cohort of patients with rheumatoid arthritis?
### Response:
| In this first community based study of extraarticular manifestations in RA, virtually all the excess mortality occurred in a subgroup of patients with severe extraarticular disease, suggesting that extraarticular disease is the major predictor of mortality in patients with RA. |
### Instruction:
Is maternal serum HCG higher in the presence of a female fetus as early as week 3 post-fertilization?
### Response:
| Because a fetal gender-related difference in MSHCG can be demonstrated as early as week 3 post-fertilization, the difference may be attributed to placental factors and not to the effects of the fetal hypothalamic-hypophyseal-gonadal axis. |
### Instruction:
Does stability of cytadherence-related proteins P140/P110 in Mycoplasma genitalium require MG218 and unidentified factors?
### Response:
| Expression of truncated MG218 in M. genitalium mg218 mutants appears to be due to the presence of a putative promoter upstream to the point of mg218 disruption; this truncated protein possesses the C-terminal region of MG218. However, pulse chase results from spontaneously arising, non-cytadhering P140-deficient M. gen... |
### Instruction:
Is acute postischemic renormalization of the apparent diffusion coefficient of water associated with reversal of astrocytic swelling and neuronal shrinkage in rats?
### Response:
| Reperfusion-induced acute renormalization of ADC values is not associated with the reversal of neuronal shrinkage and astrocytic swelling that occur during ischemia. Conversely, the morphologic changes of astrocytes and neurons progressively worsen over time, although ADC values show a biphasic change. |
### Instruction:
Does a moderate carbohydrate and fat diet impair strength performance in moderately trained males?
### Response:
| These findings indicate that varying dietary macronutrient content (HC/LF or MC/MF) had no effect on exercise training or strength exercise performance in moderately trained (aerobic and strength) or sedentary males. |
### Instruction:
Does precordial QT dispersion predict inducibility of ventricular tachyarrhythmias at post-revascularization electrophysiologic study?
### Response:
| Coronary artery revascularization decreased QT interval dispersion in patients with hemodynamically significant VT, but QT interval dispersion was not predictive of inducibility of VT at follow-up electrophysiologic study. Actuarial survival was similar in patients in whom VT was induced and patients in whom VT was not... |
### Instruction:
Do estrogens ameliorate remote organ inflammation induced by burn injury in rats?
### Response:
| We propose that treatment with estrogens or antiandrogens might be applicable in clinical situations to ameliorate systemic inflammation induced by burn. |
### Instruction:
Does low molecular weight heparin inhibit tumor necrosis factor alpha-induced leukocyte rolling?
### Response:
| Taken together, these findings indicate that LMWH inhibits TNF-alpha-induced leukocyte accumulation by inhibiting the rolling adhesive interaction which may help explain the anti-inflammatory effects of LMWH. |
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