question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Does [ Ganciclovir induce apoptosis of rat C6 glioma cell transduced with HSV-tk gene ]?
### Response:
| The apoptosis of transduced C6/tk glioma was induced by GCV, which fit in with the basis of HSV-tk-GCV gene therapy for glioma. |
### Instruction:
Does cCR5 mediate specific migration of Toxoplasma gondii-primed CD8 lymphocytes to inflammatory intestinal epithelial cells?
### Response:
| Our data emphasize the biologic role of CCR5 as an important component in the migration of intraepithelial CD8(+) T cells and the regulation of the inflammatory response following parasite infection. |
### Instruction:
Does thirty minutes mobile phone use have no short-term adverse effects on central auditory pathways?
### Response:
| Based on the ABR and MLR methods utilized in the study, we conclude that 30 min mobile phone use has no short-term adverse effects on the human auditory system. |
### Instruction:
Do alphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients?
### Response:
| The alphav- and beta1-integrin subunits are frequently expressed in ovarian carcinoma cells in effusions, and the alphav-integrin subunit is a powerful diagnostic marker for carcinoma cells. The reduced expression of the beta1-integrin subunit in solid lesions may be attributed to the role of other subunits at these st... |
### Instruction:
Does hyper-IL-15 suppress metastatic and autochthonous liver cancer by promoting tumour-specific CD8+ T cell responses?
### Response:
| Liver delivery of hyper-IL-15 provides an effective therapy against well-established metastatic and autochthonous liver cancers in mouse models by preferentially expanding tumour-specific CD8(+) T cells and promoting their anti-tumour effects. |
### Instruction:
Is the E3 ligase RNF34 a novel negative regulator of the NOD1 pathway?
### Response:
| These findings confirm that RNF34 is a negative regulator of the NOD1 pathway through direct interaction and ubiquitination of NOD1, and suggest a novel regulatory mechanism of NOD1. |
### Instruction:
Is aortic surgery one of the risk factors for enhancement of pressure wave reflection in adult patients with congenital heart disease?
### Response:
| The history of aortic surgeries enhances aortic pressure wave reflection in adult patients with congenital heart disease. The enhanced aortic pressure wave reflection is one of the risk factors for cardiovascular diseases. Therefore, the adult patients with congenital heart disease after aortic surgeries should be care... |
### Instruction:
Does thyrotropin increase hepatic triglyceride content through upregulation of SREBP-1c activity?
### Response:
| TSH increased the hepatic triglyceride content, indicating an essential role for TSH in the pathogenesis of NAFLD. |
### Instruction:
Are multiple psychological factors associated with poorer functioning in a sample of community-dwelling knee osteoarthritis patients?
### Response:
| The results reveal that both pain self-efficacy and negatively charged emotion and expectations toward pain are important factors when dealing with knee OA patients. Failure to consider these will probably contribute to prolonged disability and further pain. The results call for the routine assessment of multiple psych... |
### Instruction:
Do hypoxic/ischemic and infectious events have cumulative effects on the risk of cerebral palsy in very-low-birth-weight preterm infants?
### Response:
| Hypoxic/ischemic and infectious events across the perinatal and neonatal periods exerted cumulative effects on CP risk in VLBW premature infants. |
### Instruction:
Does partial Calcanectomy facilitate Wound Closure of Heel Defects in High-Risk Patients?
### Response:
| In this study, we demonstrate that partial calcanectomy is practical for the treatment of plantar heel ulcers in patients with severe comorbidities. With proper surgical planning and postoperative care, partial calcanectomy is a viable alternative to below-the-knee amputation and may better serve the patient who would ... |
### Instruction:
Is boarding associated with higher rates of medication delays and adverse events but fewer laboratory-related delays?
### Response:
| Compared with inpatient units, ED boarding was associated with more medication-related delays and adverse events but fewer laboratory-related delays. Until we can eliminate ED boarding, it is critical to identify areas for improvement. |
### Instruction:
Are anxiety disorders associated with quality of life impairment in patients with insulin-dependent type 2 diabetes : a case-control study?
### Response:
| This study demonstrates the importance of diagnosing and treating anxiety disorders in patients with diabetes, so as to prevent more serious complications associated with these comorbidities. |
### Instruction:
Does enamel matrix derivative protein enhance production of matrixmetalloproteinase-2 by osteoblasts?
### Response:
| P38 MAPK pathway promotes expression MMP-2 in EMD activated osteoblasts, which in turn stimulates periodontal regeneration by degrading matrix proteins in periodontal connective tissue. |
### Instruction:
Does hELP LDL apheresis reduce plasma pentraxin 3 in familial hypercholesterolemia?
### Response:
| FH is associated with increased plasma PTX3, which is acutely reduced by HELP LDL apheresis independently of LDL cholesterol, as reflected by the lack of association between change in PTX3 and in LDL levels. These results, together with the finding of a negative relationship between PTX3 and duration of treatment sugge... |
### Instruction:
Is hormone secretion by pituitary adenomas characterized by increased disorderliness and spikiness but more regular pulsing?
### Response:
| This study extends the understanding of disorganized hormone secretion by hyperfunctioning pituitary adenomas. The new findings are increased spikiness in all 3 tumor groups and increased pulsing regularity in GH- and ACTH-secreting adenomas. The mechanisms behind the marked pattern irregularity and the selective norma... |
### Instruction:
Does lZTFL1 suppress gastric cancer cell migration and invasion through regulating nuclear translocation of β-catenin?
### Response:
| LZTFL1 suppresses GC cell EMT by inhibiting β-catenin nuclear translocation. Re-expression of LZTFL1 in GC cells may be a potential therapeutic means to prevent GC metastasis. |
### Instruction:
Is severe chronic periodontitis associated with endothelial and microvascular dysfunctions : a pilot study?
### Response:
| Severe CP was directly associated with endothelial and microvascular dysfunctions. |
### Instruction:
Does cD40 promote the development of early diabetic retinopathy in mice?
### Response:
| CD40-deficient mice were protected fromthe development of diabetic retinopathy. These mice exhibited diminished inflammatory responses linked to diabetic retinopathy. CD40 stimulation of retinal cells triggered these pro-inflammatory responses. |
### Instruction:
Does alveolar type II cell transplantation restore pulmonary surfactant protein levels in lung fibrosis?
### Response:
| One of the mechanisms involved in the beneficial effect of alveolar Type II cell transplantation is restoration of lung surfactant protein levels, which is required for proper respiratory function. |
### Instruction:
Does a rare novel mutation in TECTA cause autosomal dominant nonsyndromic hearing loss in a Mongolian family?
### Response:
| A novel missense mutation c.6016 G > T (p.Asp2006Tyr) of TECTA gene is a characteristic TECTA-related mutation which causes autosomal dominant nonsyndromic hearing loss. Our result indicated that mutation in TECTA gene is responsible for the hearing loss in this Mongolian family. |
### Instruction:
Does activation of the GPR30 receptor promote lordosis in female mice?
### Response:
| This study demonstrates that activation of the mER GPR30 stimulates social behavior in a rodent model in a manner similar to EB. |
### Instruction:
Are β-catenin ( CTNNB1 ) mutations associated with prognosis in advanced hepatocellular carcinoma?
### Response:
| In patients with advanced HCC, CTNNB1 mutations were not prognostically significant. No apparent increase of CTNNB1 mutations occurred during the progression of HCC. |
### Instruction:
Do the outcome of antibiotic therapy for uncomplicated appendicitis with diameters ≤ 10 mm?
### Response:
| Antibiotic therapy without surgery may be a safe treatment for uncomplicated appendicitis in select patients with appendiceal diameters ≤ 10 mm. |
### Instruction:
Is hIV protease inhibitor use during pregnancy associated with decreased progesterone levels , suggesting a potential mechanism contributing to fetal growth restriction?
### Response:
| Our data suggest that PI use in pregnancy may lead to lower progesterone levels that could contribute to adverse birth outcomes. |
### Instruction:
Are higher serum S100B and BDNF levels correlated with a lower pressure-pain threshold in fibromyalgia?
### Response:
| Both neuroglia key mediators in the CS process were inversely correlated with the PPT. Serum assessment of BDNF and S100B deserve further study to determine its potential as a proxy for the CS spectrum in FM. |
### Instruction:
Is intrusive trauma recollections associated with impairment of interference inhibition and psychomotor speed in PTSD?
### Response:
| Impaired interference control may be related to internal (re-experiencing) and external (sensory) stimuli that leads to cognitive deficits in PTSD patients. |
### Instruction:
Does a functional EGF+61 polymorphism is associate with severity of obstructive sleep apnea?
### Response:
| Our study showed that AG genotype has a protective effect on OSA patients against severe disease, although EGF 61A/G polymorphisms have no role on the risk of the disease. Additional large studies should further validate our findings. |
### Instruction:
Does gene network-based analysis identify two potential subtypes of small intestinal neuroendocrine tumors?
### Response:
| An integrated cellular transcriptomic analysis of small intestinal neuroendocrine tumors identified that they are regulated at a developmental level, have key activation of hypoxic pathways (a known regulator of malignant stem cell phenotypes) as well as activation of genes involved in apoptosis and proliferation. Furt... |
### Instruction:
Do foot placement and arm position affect the five times sit-to-stand test time of individuals with chronic stroke?
### Response:
| Our results showed that foot placement and arm position could influence the FTSTS times of individuals with chronic stroke. Standardizing the foot placement and arm position in the test procedure is essential, if FTSTS test is intended to be used repeatedly on the same subject. |
### Instruction:
Does salinity-mediated cyanogenesis in white clover ( Trifolium repens ) affect trophic interactions?
### Response:
| The results suggest that soil salinity leads to an upregulation of cyanogenesis in white clover, which results in enhanced resistance against two different natural herbivores. The potential implications for such salinity-mediated changes in plant defence for livestock grazing remain to be tested. |
### Instruction:
Is involuntary detrusor contraction a frequent finding in patients with recurrent urinary tract infections?
### Response:
| Patients with rUTI present with covert bladder dysfunctions represented by detrusor overactivity. |
### Instruction:
Does compression garment promote muscular strength recovery after resistance exercise?
### Response:
| Wearing a CG after resistance exercise facilitates the recovery of muscular strength. Recovery for upper body muscles significantly improved within 3-8 h after exercise. However, facilitation of recovery of lower limb muscles by wearing the CG took a longer time. |
### Instruction:
Do patients with schizophrenia demonstrate reduced cortical sensitivity to auditory oddball regularities?
### Response:
| These findings further clarify differences in HC and SZ with regard to their attentional and perceptual sensitivity to subtle environmental regularities. |
### Instruction:
Is health care worry associated with worse outcomes in multiple sclerosis?
### Response:
| Health care worry was significantly related to psychological, physical, and cognitive symptoms. Future research should compare health care worry in MS with other populations (i.e., healthy adults) and should examine changes in health care worry over time. |
### Instruction:
Does cost estimate of hospital stay for premature newborns of adolescent mothers in a Brazilian public hospital?
### Response:
| This study demonstrated that the average cost of premature newborns from adolescent mothers was US$2,328.00 and varied according to birth weight. For those weighing <1,000g at birth, the mean direct cost was US$8,930.00 per stay as opposed to a cost of US$642.00 for those with birth weight >2,000g. The overall estimate... |
### Instruction:
Does effects of hip abductor muscle forces and knee boundary conditions on femoral neck stresses during simulated fall?
### Response:
| Contraction of the hip abductor muscles at the moment of impact during a fall, and landing with the knee free of constraints, substantially reduced peak compressive and tensile stresses at the femoral neck and risk for femoral fracture in a sideways fall. |
### Instruction:
Does the effect of radioactive iodine treatment on 14C urea breath test result in patients with hyperthyroidism?
### Response:
| Our findings indirectly showed that RAIT might have an antimicrobial effect on H. pylori. Clinical applications of this beneficial effect of RAIT on H. pylori should be further evaluated. |
### Instruction:
Does caffeine inhibit migration in glioma cells through the ROCK-FAK pathway?
### Response:
| Caffeine decreased the migration of glioma cell through the ROCK-focal adhesion complex pathway; this mechanism may be useful as part of clinical therapy in the future. |
### Instruction:
Are t-type calcium channels involved in hypoxic pulmonary hypertension?
### Response:
| The present study demonstrates that T-VGCCs contribute to intrapulmonary vascular reactivity and is implicated in the development of hypoxic PH. Specific blockers of T-VGCCs may thus prove useful for the therapeutic management of PH. |
### Instruction:
Do altered brain network modules induce helplessness in major depressive disorder?
### Response:
| The limited size of MDD samples precluded meaningful study of distinct clinical characteristics in relation to aberrant FC. |
### Instruction:
Does elevated soluble VEGF receptor sFlt-1 correlate with endothelial injury in IgA nephropathy?
### Response:
| The present study found elevated sFlt-1 in IgAN patients and further identified its correlation with proteinuria, hypertension and vWF levels. These results suggested that elevated sFlt-1 contributes to endothelial injury in IgAN. |
### Instruction:
Is bone formation suppressed with multi-stressor military training?
### Response:
| These data indicate that multi-stressor military training results in increased bone resorption and suppressed bone formation, with recovery of bone metabolism 2-6 weeks after completion of training. |
### Instruction:
Does a large-scale RNAi-based mouse tumorigenesis screen identify new lung cancer tumor suppressors that repress FGFR signaling?
### Response:
| A functional genomics approach identifies new lung TSGs whose loss aberrantly increases FGFR signaling to promote tumorigenesis. These TSGs are frequently downregulated in hLSCCs, indicating that increased FGFR signaling promotes tumorigenesis in many hLSCCs lacking FGFR1 amplification or activating mutations. |
### Instruction:
Does intestine-specific deletion of microsomal triglyceride transfer protein increase mortality in aged mice?
### Response:
| Blocking intestinal chylomicron secretion alters mortality following sepsis in an age-dependent manner. Increases in gut apoptosis and pulmonary neutrophil infiltration, and decreased systemic TNFα represent potential mechanisms for why intestine-specific Mttp deletion is beneficial in young septic mice but harmful in ... |
### Instruction:
Does entecavir treatment eliminate the risk of hepatocellular carcinoma in chronic hepatitis B : limited role for risk scores in Caucasians?
### Response:
| Cumulative incidence of HCC is low in patients treated with ETV, but ETV does not eliminate the risk of HCC. Discriminatory performance of HCC risk scores was limited, particularly in Caucasians, at baseline and during therapy. |
### Instruction:
Does targeting tumour necrosis factor receptor 1 assembly reverse Th17-mediated colitis through boosting a Th2 response?
### Response:
| The Th2 cytokine milieu induced by PLAD.Fc rebalanced T-helper cell subsets and conferred a protection against colitis in BLIMP-1 knockout mice. |
### Instruction:
Does a highly-sensitive anti-Müllerian hormone assay improve analysis of ovarian function following chemotherapy for early breast cancer?
### Response:
| The 10-fold increased assay sensitivity showed very clear distinction between groups based on ovarian activity with excellent prediction of future menses or amenorrhoea. This will improve assessment of post-chemotherapy ovarian function in women and may aid treatment decisions. |
### Instruction:
Does oral rabeprazole administration on a procedure day suppress bleeding after endoscopic submucosal dissection for gastric neoplasms?
### Response:
| Oral RPZ administration on the day of gastric ESD can suppress post-ESD bleeding equivalently to administration three days before ESD. |
### Instruction:
Does metabolic health reduce risk of obesity-related cancer in framingham study adults?
### Response:
| These results suggest that cancer risk may be lower among metabolically healthy overweight/obese older adults than among overweight/obese adults with metabolic dysfunction. |
### Instruction:
Does coronary artery calcification on computed tomography correlate with mortality in chronic obstructive pulmonary disease?
### Response:
| Coronary artery calcification severity and emphysema severity on CT images are related and are strongly as well as independently associated with prognosis in patients with moderate to severe COPD. The potential to use CAC OVS on unenhanced nongated CT as a screening tool for coronary artery disease and as a prognostic ... |
### Instruction:
Do dPP-4 inhibitors repress NLRP3 inflammasome and interleukin-1beta via GLP-1 receptor in macrophages through protein kinase C pathway?
### Response:
| DPP-4 inhibitors suppress NLRP3, TLR4 and IL-1β in human macrophages through inhibition of PKC activity. This study provides novel insights into the mechanism of inhibition of inflammatory state and immune response in atherosclerosis by DPP-4 inhibitors. |
### Instruction:
Are nF-κB signaling and vesicle transport correlated with the reactivation of the memory trace of morphine dependence?
### Response:
| The current study indicates that NF-κB signaling and vesicular transport are correlated with the reactivation of the memory trace in morphine-dependent mice. The results obtained in our study agree with previous observations and identify additional candidate genes for further research. |
### Instruction:
Is laparoscopy for rectal cancer oncologically adequate : a systematic review and meta-analysis of the literature?
### Response:
| Based on the evidence from RCTs and non-RCTs, the short-term benefit and oncological adequacy of laparoscopic rectal resection appear to be equivalent to open surgery, with some evidence potentially pointing to comparable long-term outcomes and oncological adequacy in selected patients with primary resectable rectal ca... |
### Instruction:
Do indices of methylation in sperm DNA from fertile men differ between distinct geographical regions?
### Response:
| Geographical region resulted associated with the sperm methylation status assessed on genome-wide repetitive sequences. |
### Instruction:
Do uremic conditions drive human monocytes to pro-atherogenic differentiation via an angiotensin-dependent mechanism?
### Response:
| Taken together, these data demonstrate that uremia induced expression of monocytic-ACE mediates the development of highly pro-atherogenic cells via an AngII-dependent mechanism. |
### Instruction:
Do physiologically achievable doses of resveratrol enhance 3T3-L1 adipocyte differentiation?
### Response:
| Our results report for the first time that resveratrol at physiologically achievable doses (1 and 10 µM) enhances 3T3-L1 adipocyte differentiation, which supports the emerging paradigm that enhanced adipocyte differentiation may be associated with caloric restriction-like metabolic effects for resveratrol. |
### Instruction:
Does saccharin consumption increase sperm DNA fragmentation and apoptosis in mice?
### Response:
| Saccharin consumption may have negative effects on sperm parameters, and increases the rate of sperm DNA fragmentation and apoptosis in mice. |
### Instruction:
Does normal mesenteric lymph ameliorate acute kidney injury following lipopolysaccharide challenge in mice?
### Response:
| The current results indicate that NML alleviates LPS-induced AKI through its attenuation of sensitization to LPS. |
### Instruction:
Does the vagus nerve alter the pulmonary dendritic cell response to injury?
### Response:
| VNS is an effective method to limit pulmonary DC recruitment to the lung and prevent ALI after burn injury. Identifying strategies to limit inflammatory cell recruitment to the lung may have clinical utility in preventing ALI in severely burned patients. |
### Instruction:
Does lower health literacy predict smoking relapse among racially/ethnically diverse smokers with low socioeconomic status?
### Response:
| Findings suggest that lower HL may serve as an independent risk factor for smoking relapse among low-SES, racially/ethnically diverse smokers enrolled in treatment. Future research is needed to investigate longitudinal relations between HL and cessation outcomes and potential mechanisms of this relationship. |
### Instruction:
Does disease-regulated local IL-10 gene therapy diminish synovitis and cartilage proteoglycan depletion in experimental arthritis?
### Response:
| Our study shows that promoters of genes that are expressed locally during arthritis can be candidates for disease-regulated overexpression of biologics into arthritic joints, as shown for IL-10 in SCW arthritis. The disease-inducible approach might be promising for future tailor-made local gene therapy in arthritis. |
### Instruction:
Do tendon proper- and peritenon-derived progenitor cells have unique tenogenic properties?
### Response:
| Data demonstrate that, relative to peritenon-derived progenitors, tendon proper progenitors have greater potential for forming functional tendon-like tissue. Furthermore, factors secreted by peritenon-derived progenitors suggest a trophic role for this cell type as well. Thus, these findings highlight the synergistic p... |
### Instruction:
Does early lung ultrasonography predict the occurrence of acute respiratory distress syndrome in blunt trauma patients?
### Response:
| LUS on admission identifies patients at risk of developing ARDS after blunt trauma. In addition, LUS allows rapid and accurate diagnosis of common traumatic thoracic injuries. |
### Instruction:
Is corneal wound healing , a newly identified function of CAP37 , mediated by protein kinase C delta ( PKCδ )?
### Response:
| These findings support the hypothesis that CAP37 facilitates corneal wound healing through the activation of PKCδ. |
### Instruction:
Are low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy associated with local immune activation?
### Response:
| Low-level CSF HIV-1 RNA and its association with elevated CSF neopterin highlight the potential for the CNS to serve as a viral reservoir and for persistent infection to cause subclinical CNS injury. |
### Instruction:
Does inhibition of G9a induce DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma?
### Response:
| In this study, we provide evidence that G9a confers the survival advantage of HNSCC. Genetic or pharmacological inhibition of G9a induces autophagic cell death; this finding provides a basis for new therapeutic targets for treating HNSCC. |
### Instruction:
Is a high copy number of FCGR3B associated with psoriasis vulgaris in Han Chinese?
### Response:
| A high copy number of FCGR3B is associated with psoriasis vulgaris in Han Chinese. |
### Instruction:
Is bradycardia associated with future cardiovascular diseases and death in men from the general population?
### Response:
| Bradycardia, as well as a higher pulse rate, may be an independent risk factor for future cardiovascular events in apparently healthy men. |
### Instruction:
Does the Mbd1-Atf7ip-Setdb1 pathway contribute to the maintenance of X chromosome inactivation?
### Response:
| Together, these data indicate that Atf7ip acts in a synergistic fashion with DNA methylation and Xist RNA to maintain the silent state of the Xi in somatic cells, and that Mbd1 and Setdb1, similar to Atf7ip, play a functional role in Xi silencing. We therefore propose that ATF7IP links DNA methylation on the Xi to SETD... |
### Instruction:
Does miR-20a inhibit cutaneous squamous cell carcinoma metastasis and proliferation by directly targeting LIMK1?
### Response:
| Our study demonstrated that miR-20a is involved in the tumor inhibition of CSCC by directly targeting LIMK1 gene. This finding provides potential novel strategies for therapeutic interventions of CSCC. |
### Instruction:
Does an overweight or obese status in childhood predict subclinical atherosclerosis and prehypertension/hypertension in young adults?
### Response:
| This study highlights the importance of preventing and treating an overweight or obese status in childhood for the primary prevention of cardiovascular disease in adulthood. |
### Instruction:
Are acute changes in mood induced by subthalamic deep brain stimulation in Parkinson disease modulated by psychiatric diagnosis?
### Response:
| PD participants diagnosed with current mood or anxiety disorders are more sensitive to STN DBS-induced effects on mood, possibly indicating altered basal ganglia circuitry in this group. |
### Instruction:
Does hydrogen sulfide treatment ameliorate long-term renal dysfunction resulting from prolonged warm renal ischemia-reperfusion injury?
### Response:
| H2S treatment improved long-term renal function and decreased long-term inflammation associated with warm IRI, and may offer a novel therapeutic approach to preventing warm IRI-induced renal injury associated with renal surgical procedures. |
### Instruction:
Does pharmacokinetics and local safety profile of propranolol eye drop in rabbits?
### Response:
| Propranolol eye drops are able to ensure high retinal and low plasma concentrations of propranolol, and this finding opens the perspective of possible topical treatment with propranolol in newborns with retinopathy of prematurity. |
### Instruction:
Is podocalyxin a marker of poor prognosis in colorectal cancer?
### Response:
| Podocalyxin was an independent factor for poor prognosis in colorectal cancer and in the subgroups of left hemicolon and rectum. This is, to our knowledge, the first evidence of such difference in PODXL expression, its function possibly being dependent upon tumour location. |
### Instruction:
Do distinct patterns of ALDH1A1 expression predict metastasis and poor outcome of colorectal carcinoma?
### Response:
| Our results indicate that RA/C is a novel biomarker to reflect the distinct expression patterns of ALDH1A1 for predicting metastasis and prognosis of CRC. |
### Instruction:
Does immune derangement occur in patients with H7N9 avian influenza?
### Response:
| Patients with avian H7N9 virus infection display profound SIRS concomitantly with an anti-inflammatory response, which may be associated with the rapid progression of and high mortality associated with this novel viral disease. |
### Instruction:
Are low levels of blood lipids associated with etiology and lethal outcome in acute liver failure?
### Response:
| In our cohort of patients with ALF, we could show that HDL and cholesterol are suppressed. In addition novel etiology specific patterns between acteminophen and non-acteminophen induced liver failure were detected for serum lipid components. Further studies are needed to address the role of cholesterol and lipid metabo... |
### Instruction:
Does mutant allele frequency predict the efficacy of EGFR-TKIs in lung adenocarcinoma harboring the L858R mutation?
### Response:
| The MAF may be a potential predictive factor of TKI treatment efficacy in patients with AELAd carrying the L858Rm. |
### Instruction:
Do bRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence?
### Response:
| Coexisting BRAF V600E and TERT C228T mutations form a novel genetic background that defines PTC with the worst clinicopathologic outcomes, providing unique prognostic and therapeutic implications. |
### Instruction:
Is leaf hydraulic vulnerability to drought linked to site water availability across a broad range of species and climates?
### Response:
| The findings indicate that species sorting processes have influenced distributional patterns of P50leaf across the rainfall spectrum, but alternative strategies for dealing with water deficit exist within sites. The strong link to aridity suggests leaf hydraulic vulnerability may influence plant distributions under fut... |
### Instruction:
Is shisa3 associated with prolonged survival through promoting β-catenin degradation in lung cancer?
### Response:
| Our results reveal that Shisa3 acts as a tumor suppressor by acceleration of β-catenin degradation and provide new insight for cancer prognosis and therapy. |
### Instruction:
Does mCP-1 stimulate MMP-9 expression via ERK 1/2 and p38 MAPK signaling pathways in human aortic smooth muscle cells?
### Response:
| These data demonstrate that MCP-1 stimulates secretion of MMP-9 directly through the ERK1/2 and p38 MAPK mediated pathways in HASMCs. Thus, inhibition of this molecular mechanism might be a potential therapeutic target in the non-surgical treatment of AAA. |
### Instruction:
Does analysis and injury paterns of walnut tree fall in central anatolia of turkey?
### Response:
| [corrected] Falls from walnut trees are a significant health problem. Preventive measures including education of farmers and agricultural workers and using mechanized methods for harvesting walnut will lead to a dramatic decrease in mortality and morbidity caused by falls from walnut trees. |
### Instruction:
Does tAT-mediated delivery of neuroglobin attenuate apoptosis induced by oxygen-glucose deprivation via the Jak2/Stat3 pathway in vitro?
### Response:
| Our results demonstrate that TAT-Ngb can protect neuron-like cells against OGD-induced apoptosis by activating the Jak2/Stat3 pathway. |
### Instruction:
Are circulating chemerin levels increased in first-degree relatives of type 2 diabetic patients?
### Response:
| These findings showed a significant increase of chemerin levels in FDR subjects which suggested that chemerin may be involved in the development and progression of insulin resistance. |
### Instruction:
Does analytic morphomics correspond to functional status in older patients?
### Response:
| Older surgical candidates with greater trunk muscle size, or greater TPA, are less likely to have physical impairment, cognitive difficulty, or decreased ability to perform daily self-care. Further research linking these assessments to clinical outcomes is needed. |
### Instruction:
Does early weight-bearing after periacetabular osteotomy lead to a high incidence of postoperative pelvic fractures?
### Response:
| The accelerated rehabilitation protocol seems to have advantages for early muscle recovery in patients undergoing PAO; however, postoperative pelvic fracture rates were unacceptably high in patients with this protocol. |
### Instruction:
Do diets that differ in their FODMAP content alter the colonic luminal microenvironment?
### Response:
| Diets differing in FODMAP content have marked effects on gut microbiota composition. The implications of long-term reduction of intake of FODMAPs require elucidation. |
### Instruction:
Does denatonium induce secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways?
### Response:
| Our study demonstrates that activation of gut-expressed bitter taste receptors stimulates GLP-1 secretion in a PLC-dependent manner. In diabetic mice, DB (a ligand of bitter taste receptor cells), when given via gavage, lowers blood glucose levels in diabetic mice after oral glucose administration, through increased se... |
### Instruction:
Does overexpression of miR-19b impair cardiac development in zebrafish by targeting ctnnb1?
### Response:
| Our findings suggest that miR-19b regulates laterality development and heart looping in zebrafish embryos by targeting ctnnb1. |
### Instruction:
Do mesenchymal stromal cells promote tumor progression in fibrosarcoma and gastric cancer cells?
### Response:
| We observed morphological evidence for MSC-associated tumor progression of fibrosarcomas and gastric cancer cells. |
### Instruction:
Does naproxen affect osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules?
### Response:
| These results indicate that Npx can affect gene expression during osteogenic differentiation of MSCs, and downregulate mineral deposition in the extracellular matrix through IHH signaling. Therefore, Npx could affect MSC-mediated repair of subchondral bone in OA patients. |
### Instruction:
Is granular corneal dystrophy type 2 associated with morphological abnormalities of meibomian glands?
### Response:
| In GCD2, corneal deposits, and also morphological abnormalities of meibomian glands, such as obstruction or shortening, were found. Since abnormal phospholipid deposition is noted in GCD2, these results are interesting because phospholipid is possibly secreted from the meibomian gland. |
### Instruction:
Are depressive symptoms associated with obesity in adults with heart failure : An analysis of gender differences?
### Response:
| BMI is related to depressive symptoms in adults with heart failure even after adjusting for demographic and medical covariates. Depressive symptoms were associated with BMI in males, whereas a trend was detected among females. These findings could ultimately be used to improve heart failure outcomes for depressed, obes... |
### Instruction:
Is repeated transabdominal ultrasonography a simple and accurate strategy to diagnose a biliary etiology of acute pancreatitis?
### Response:
| Repeated US is effective for biliary AP diagnosis. The combination of repeated US examinations and biochemical tests seems an effective approach, whereas magnetic resonance cholangiopancreatography might be restricted to selected cases. |
### Instruction:
Does s100A4 regulate the Src-tyrosine kinase dependent differentiation of Th17 cells in rheumatoid arthritis?
### Response:
| The present study demonstrates that S100A4 plays an important part in the pathogenesis of arthritis. It controls CD5-dependent differentiation of Th17 cells by regulating the activity of the Src-family kinases Lck and Fyn. |
### Instruction:
Does [ MiR-124 suppress the proliferation of human prostate cancer PC3 cells by targeting PKM2 ]?
### Response:
| miR-124 can suppress the proliferation of PC3 cells by regulating the PKM2 gene. |
### Instruction:
Does unbiased analysis of pancreatic cancer radiation resistance reveal cholesterol biosynthesis as a novel target for radiosensitisation?
### Response:
| Unbiased pathway analysis of radioresistance allowed for the discovery of novel pathways associated with resistance to ionising radiation in PC. Specifically, our analysis indicates the importance of the cholesterol synthesis pathway in PC radioresistance. Further, a novel radiosensitiser, ZOL, showed promising results... |
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