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### Instruction:
Does small heterodimer partner block cardiac hypertrophy by interfering with GATA6 signaling?
### Response:
| These results establish SHP as a novel antihypertrophic regulator that acts by interfering with GATA6 signaling. SHP may participate in the metformin-induced antihypertrophic response. |
### Instruction:
Does miR-195 affect cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung 's disease?
### Response:
| Aberrant expression of miR-195 may involved in the pathogenesis of HSCR by down-regulated the level of DIEXF. |
### Instruction:
Does pittsburgh outcomes after stroke thrombectomy score predict outcomes after endovascular therapy for anterior circulation large vessel occlusions?
### Response:
| POST score is a validated predictor of outcome in patients with anterior circulation large vessel occlusions after endovascular therapy. |
### Instruction:
Does phosphodiesterase-3 inhibitor ( cilostazol ) attenuate oxidative stress-induced mitochondrial dysfunction in the heart?
### Response:
| Our findings suggest that cardioprotective effects of cilostazol reported previously could be due to its prevention of cardiac mitochondrial dysfunction caused by severe oxidative stress. |
### Instruction:
Is low-cost semirigid ureteroscopy effective for ureteral stones : experience of a single high volume center?
### Response:
| This study demonstrates that the use of Holmium laser lithotripsy is a safe and effective means of treating ureteral stones regardless of sex, age, stone location, or stone size. The instrumentation we used was extremely limited, in order to reduce costs related to the procedure to an absolute minimum whilst maintainin... |
### Instruction:
Is fOLFIRINOX bevacizumab a promising therapy for chemorefractory metastatic colorectal cancer?
### Response:
| This study suggests that bevacizumab + FOLFIRINOX may be active in mCRC patients after failure of classical lines of chemotherapy. |
### Instruction:
Does exosomal shuttling of miR-126 in endothelial cells modulate adhesive and migratory abilities of chronic myelogenous leukemia cells?
### Response:
| Our results show that the miR-126 shuttled by exosomes is biologically active in the target cells, and support the hypothesis that exosomal miRNAs have an important role in tumor-endothelial crosstalk occurring in the bone marrow microenvironment, potentially affecting disease progression. |
### Instruction:
Does bedside ultrasound of the neck confirm endotracheal tube position in emergency intubations?
### Response:
| In this emergency setting, ultrasound determined ETT locations rapidly with 100 % accuracy and independently of the CL-category. |
### Instruction:
Are strength field tests performance correlated with isokinetic strength of shoulder rotator muscles in female handball players?
### Response:
| We suggested the use of field test to infer about internal and external rotator muscular strength, but not to infer about isokinetic muscular strength ratios. These findings could be useful to coaches and trainers. |
### Instruction:
Do elite cross-country skiers reach their running VO2max during roller ski skating?
### Response:
| Elite cross-country skiers do not elicit higher VO2max during roller ski skating than during running and this relationship does not change during the pre-season training period. |
### Instruction:
Does white matter correlate of cognitive dysfunction after mild traumatic brain injury?
### Response:
| Acute mild/moderate traumatic brain injury is characterized by increased tissue FA, which represents a clear neurobiological link between cognitive dysfunction and white matter injury after mild/moderate injury. |
### Instruction:
Does miR-126 inhibit the invasion of gastric cancer cell in part by targeting Crk?
### Response:
| Our results demonstrated that overexpression of miR-126 inhibited GC cells invasion in part by targeting Crk. These findings suggested that miR-126 played major roles in the malignant behavior of GC and it might be a promising therapeutic target of GC. |
### Instruction:
Is p38 mitogen-activated protein kinase involved in arginase-II-mediated eNOS-uncoupling in obesity?
### Response:
| Taking together, we demonstrate here for the first time that Arg-II causes eNOS-uncoupling through activation of p38 mapk in HFD-induced obesity. |
### Instruction:
Do antibodies specific for carbamylated proteins precede the onset of clinical symptoms in mice with collagen induced arthritis?
### Response:
| In mice with collagen induced arthritis we did not observe an immune response against citrullinated antigens, but we did observe an immune response against carbamylated antigens. This anti-CarP response already appeared before disease onset, indicating that collagen induced arthritis can be used as an in vivo model to ... |
### Instruction:
Does reproductive senescence blunt response of estrogen receptor-α expression to estrogen treatment in rat post-ischemic cerebral microvessels?
### Response:
| Chronic treatment with CE increases ER-α but not ER-β expression in cerebral microvessels of OVX rats. Aging appears to reduce the normal ability of estrogen to increase ER-α expression in postischemic cerebral microvessels. |
### Instruction:
Does the lncRNA PCAT29 inhibit oncogenic phenotypes in prostate cancer?
### Response:
| This study identifies PCAT29 as the first androgen receptor-repressed lncRNA that functions as a tumor suppressor and that its loss may identify a subset of patients at higher risk for disease recurrence. Visual Overview: http://mcr.aacrjournals.org/content/early/2014/07/31/1541-7786.MCR-14-0257/F1.large.jpg. |
### Instruction:
Does parental monitoring affect the relationship between depressed mood and alcohol-related problems in adolescents?
### Response:
| This study highlights the protective role that parental monitoring may play in the association between depressed mood and alcohol-related problems and suggests that parenting practices, in addition to individual counseling, should be addressed in treatment of depressed adolescents who drink. |
### Instruction:
Do cervical length measured by transvaginal ultrasonography versus Bishop score to predict successful labour induction in term pregnancies?
### Response:
| In this study group significant independent prediction of vaginal delivery within 96 h is provided by the Bishop score but only in nulliparous women. Transvaginal ultrasonographic measurement of cervical length is not a significant independent predictor of vaginal delivery within 96 h. |
### Instruction:
Is hormesis induced in the red flour beetle Tribolium castaneum through ingestion of charred toast?
### Response:
| Our studies suggest a hormetic response of the red flour beetle to feeding of charred toast that causes an increased stress resistance through the activation of ahr and nrf-2. Those adaptations, however, are saturable and accordingly the hormetic effects at increasing concentrations of the toxicants become expended. |
### Instruction:
Are lymphovascular space invasion and tumor differentiation predictors for postoperative recurrence in patients with pathological stage I nonsmall cell lung cancer?
### Response:
| Tumor differentiation and LVSI were predictors of postoperative relapse for patients with pathological stage I NSCLC. Risk factors of postoperative recurrence in patients with pathological Stage I NSCLC may enable us to optimize the patient selection for postoperative adjuvant therapies to prevent possibly occult micro... |
### Instruction:
Do microRNAs participate in the murine oligodendroglial response to perinatal hypoxia-ischemia?
### Response:
| Changes in specific mature miRs expressed in OPCs following HI may contribute to white matter injury. |
### Instruction:
Are volume of training and the ranking level associated with the leakage of urine in young female trampolinists?
### Response:
| The results confirm a high frequency of UI in young trampolinists and reveal a clear identification of the athletes' ranking and the training volume as risk factors to develop and worsen urine loss. |
### Instruction:
Does kPT-330 inhibitor of XPO1-mediated nuclear export have anti-proliferative activity in hepatocellular carcinoma?
### Response:
| Our results suggest that SINE compounds, such as KPT-330, are promising novel drugs for the targeted therapy of HCC. |
### Instruction:
Do neutrophil extracellular traps promote thrombin generation through platelet-dependent and platelet-independent mechanisms?
### Response:
| These studies examine the procoagulant activities of CFDNA and histones in the context of NETs. Our studies also implicate a role for the intrinsic pathway of coagulation in sepsis pathogenesis. |
### Instruction:
Does tamoxifen ameliorate renal tubulointerstitial fibrosis by modulation of estrogen receptor α-mediated transforming growth factor-β1/Smad signaling pathway?
### Response:
| These findings indicate that tamoxifen has a beneficial effect on UUO-induced tubulointerstitial fibrosis by suppression of renal fibroblast activation via modulation of ERα-mediated renal TGF-β1/Smad signaling pathway. |
### Instruction:
Does phosphorylation status of thymidine kinase 1 following antiproliferative drug treatment mediate 3'-deoxy-3'- [ 18F ] -fluorothymidine cellular retention?
### Response:
| We have defined a regulatory role of TK1 phosphorylation in mediating [18F]FLT cellular retention and hence reporting of antiproliferative activity, with implications especially for drugs that induce a G2/M cell cycle arrest. |
### Instruction:
Is miR-485-5p binding site SNP rs8752 in HPGD gene associated with breast cancer risk?
### Response:
| Through a systematic case-control study of microRNA binding site SNPs, we identified a new breast cancer risk variant rs8752 in HPGD in Chinese women. Further studies are warranted to investigate the underling mechanism for this association. |
### Instruction:
Is an Integrated Model of Executive Functioning Helpful for Understanding ADHD and Associated Disorders?
### Response:
| The present study describes different cognitive profiles in children with ADHD with or without comorbid disorders using neuropsychological EF measures. |
### Instruction:
Does acute fluctuation in blood glucose have no effect on platelet aggregation rate?
### Response:
| There is probably no need to consider the possible influence of acute blood glucose fluctuation on thrombotic events. |
### Instruction:
Is inflammatory status different in relationship to insulin resistance in severely obese people and changes after bariatric surgery or diet-induced weight loss?
### Response:
| NK cells are significantly increased in IR severely obese people in respect to IS, suggesting a slightly different immune status in these patients with a probable dietary relationship. Weight loss could reverse this increase either after VLCD or after bariatric surgery. |
### Instruction:
Are advanced glycation end products in the skin enhanced in COPD?
### Response:
| SAF is increased in mild-to-very severe COPD patients compared with healthy controls. Interestingly, SAF was not associated with disease severity as values were comparable between different GOLD stages (stage I-IV) of COPD. This may suggest that AGEs play a role in the induction phase of COPD in susceptible smokers. Fu... |
### Instruction:
Does whole-brain adaptive 70-kVp perfusion imaging with variable and extended sampling improve quality and consistency while reducing dose?
### Response:
| Seventy-kilovolt (peak) CTP with variable and extended sampling produces improved image quality at lower radiation doses with greater consistency of full contrast passage capture. |
### Instruction:
Does radiation dose reduction in CT-guided spine biopsies reduce diagnostic yield?
### Response:
| Use of a low-dose CT-guided spine biopsy protocol is a practical alternative to regular-dose approaches, maintaining overall quality and efficiency at reduced ionizing radiation dose. |
### Instruction:
Does endothelial arginine resynthesis contribute to the maintenance of vasomotor function in male diabetic mice?
### Response:
| Absence of endothelial citrulline recycling to arginine did not affect blood pressure and systemic arterial vasomotor responses in healthy mice. EDNO-mediated vasodilatation was significantly more impaired in diabetic Ass-KOTie2 than in control mice demonstrating that endothelial arginine recycling becomes a limiting e... |
### Instruction:
Is obesity still a risk factor in coronary artery bypass surgery?
### Response:
| We documented that obesity is still a risk factor for occurrence of postoperative adverse events. We believe that improved perioperative care together with meticulous regimens can improve postoperative outcomes in patients undergoing coronary artery bypass surgery. |
### Instruction:
Does lymph node involvement in colon cancer patients decrease with age ; a population based analysis?
### Response:
| When adequately staged, older patients are less likely to have node positive colon cancer, which may help them avoid adjuvant chemotherapy. Since the survival benefit of adequate nodal staging is similar in every age group, the guidelines for extent of resection and pathological examination should be diligently adhered... |
### Instruction:
Is positive expression of insulin-like growth factor-1 receptor associated with a positive hormone receptor status and a favorable prognosis in breast cancer?
### Response:
| Positive IGF-1R expression is associated with a favorable prognosis in breast cancer. IGF-1R is frequently expressed in the luminal A/B subtypes of breast cancer, and its expression is related to the hormone receptor status. |
### Instruction:
Is diclofenac associated with a reduced incidence of post-endoscopic retrograde cholangiopancreatography pancreatitis : results from a Danish cohort study?
### Response:
| This controlled cohort study suggests that the implementation of a single dose of 100 mg of diclofenac rectally administered significantly reduces the incidence of post-ERCP pancreatitis in an unselected material of patients with native papilla. |
### Instruction:
Are cFTR , SPINK1 , PRSS1 , and CTRC mutations associated with pancreatic cancer in German patients?
### Response:
| Mutations in the genes CFTR, SPINK1, PRSS1, and CTRC do not seem to significantly increase the risk for pancreatic adenocarcinoma. |
### Instruction:
Is the polymorphism in the promoter of HSP70 gene associated with heat tolerance of two congener endemic bay scallops ( Argopecten irradians irradians and A. i. concentricus )?
### Response:
| The results provided insights into the molecular mechanisms underlying the thermal adaptation of different congener endemic bay scallops, which suggested that the increased heat tolerance of A. i. concentricus (compared with A. i. irradians) was associated with the higher expression of AiHSP70. Meanwhile, the -967 GG, ... |
### Instruction:
Do the performance effect of centralizing a nation 's elite swim program?
### Response:
| Our method of quantifying deviations from individual trends in competition performance with a mixed model showed that Swimming New Zealand's centralization strategy took several years to produce substantial performance effects. The method may also be useful for evaluating performance-enhancement strategies introduced a... |
### Instruction:
Are motor Function Deficits Following Chronic Prenatal Ethanol Exposure Linked to Impairments in Insulin/IGF , Notch and Wnt Signaling in the Cerebellum?
### Response:
| Abnormalities in cerebellar function following chronic prenatal ethanol exposure are associated with inhibition of insulin/IGF, canonical Wnt, and Notch networks that cross-talk via GSK-3β. Effective therapeutic measures for FASD may require multi-pronged support of interrelated signaling networks that regulate brain d... |
### Instruction:
Does 6-Mercaptopurine reduce macrophage activation and gut epithelium proliferation through inhibition of GTPase Rac1?
### Response:
| These data demonstrate that 6-MP affects macrophages and gut epithelial cells beneficially, in addition to T cells and endothelial cells. Furthermore, mechanistic insight is provided to support development of Rac1-specific inhibitors for clinical use in inflammatory bowel disease. |
### Instruction:
Does miR-9 regulate the post-transcriptional level of VEGF165a by targeting SRPK-1 in ARPE-19 cells?
### Response:
| Hypoxic stress decreased the miR-9 level in ARPE-19 cells, which increased the transcriptional level of SRPK-1, resulting in alternative splicing shift to pro-angiogenic isoforms of VEGF165 in human retinal pigment epithelial cells. |
### Instruction:
Is an exaggerated blood pressure response to exercise associated with subclinical myocardial dysfunction in normotensive individuals?
### Response:
| Normotensive individuals with an exaggerated BP response to exercise exhibit impairment in longitudinal myocardial function. Even without apparent hypertension, an exaggerated BP response could cause repeated increases in afterload and result in subclinical myocardial dysfunction. |
### Instruction:
Is liver injury in acute hepatitis A associated with decreased frequency of regulatory T cells caused by Fas-mediated apoptosis?
### Response:
| The size of the Treg pool was contracted during AHA, resulting from apoptosis of Tregs induced by a Fas-mediated mechanism. Decrease in Treg numbers led to reduced suppressive activity of the Treg pool and consequently resulted in severe liver injury during AHA. |
### Instruction:
Does tGF β1 mediate epithelial mesenchymal transition via β6 integrin signaling pathway in breast cancer?
### Response:
| β6 integrin plays a critical role in TGF-β1-induced EMT and overexpression of COX-2 in breast cancer. |
### Instruction:
Is speed , not magnitude , of knee extensor torque production associated with self-reported knee function early after anterior cruciate ligament reconstruction?
### Response:
| At the initiation of advanced ACL reconstruction rehabilitation, the surgical side displayed deficits in peak torque and average rate of torque development. A higher rate of torque development and shorter time to peak torque were associated with better self-reported knee function. The results suggest that the rate of t... |
### Instruction:
Do increased shape and size offerings of femoral components improve fit during total knee arthroplasty?
### Response:
| The inclusion of multiple ML/AP shape offerings and the increased number of available sizes in Design A, as compared to other contemporary femoral component design families studied, result in improved femoral component fit across various ethnicities. |
### Instruction:
Does gene therapy with mitochondrial heat shock protein 70 suppress visual loss and optic atrophy in experimental autoimmune encephalomyelitis?
### Response:
| Mitochondrial HSP70 ameliorates mitochondrial dysfunction that culminates in irreversible visual loss and atrophy of the optic nerve in EAE suggesting that it may be useful to prevent irreversible disability in patients with optic neuritis and multiple sclerosis (MS). |
### Instruction:
Is overexpression of β3 Chains of Laminin-332 Associated With Clinicopathologic Features and Decreased Survival in Patients With Pancreatic Adenocarcinoma?
### Response:
| Our results suggest that LNβ3 expression may play a key role in the progression and prognosis of pancreatic ductal adenocarcinoma. |
### Instruction:
Does impact of negative clinical trial result for vertebroplasty on vertebral augmentation procedure rates?
### Response:
| Publication of negative clinical trial results led to moderate reductions in vertebroplasties and kyphoplasties for osteoporotic VCFs. However, vertebroplasty and kyphoplasty continue to be widely used to treat patients with osteoarthritis. Substantial differences in response across physicians suggest an important role... |
### Instruction:
Does porphyromonas gingivalis infection increase osteoclastic bone resorption and osteoblastic bone formation in a periodontitis mouse model?
### Response:
| P. gingivalis invades alveolar osteoblasts in the periodontitis mouse model and cause alveolar bone loss. Although P. gingivalis appears to suppress osteoblast pool and enhance osteoclastic bone resorption, the bone formation capacity is temporarily elevated in the infected mice, possibly via some anti-microbial compen... |
### Instruction:
Does better quality of mother-child interaction at 4 years of age decrease emotional overeating in IUGR girls?
### Response:
| IUGR and exposure to a negative emotional atmosphere during maternal-child interactions predicted emotional overeating in girls but not in boys. The quality of mother-infant interaction may be an important target for interventions to prevent emotional overeating and overweight in early development, particularly in girl... |
### Instruction:
Is ( 1 ) H-MRS useful to reinforce the suspicion of primary central nervous system lymphoma prior to surgery?
### Response:
| (1)H-MRS is useful to reinforce diagnostic suspicion of PCNSL on MRI. |
### Instruction:
Do an update on RNA interference-mediated gene silencing in cancer therapy?
### Response:
| Although the field of RNAi-based cancer therapy is still an emerging one, we have yet to get solutions for overcoming all obstacles associated with its clinical development. The current rapid advances in development of new targeted delivery strategies and noninvasive imaging methods will be big steps to explore RNAi as... |
### Instruction:
Are blood pressure variability , impaired autonomic function and vascular senescence in aged spontaneously hypertensive rats ameliorated by angiotensin blockade?
### Response:
| ARBs ameliorated autonomic dysfunction, BP variability, and vascular senescence in aged SHR. Olmesartan ameliorated the aging-related disorders better than valsartan and was associated with longer-lasting AT1 receptor inhibition by olmesartan. Thus, the magnitude of improvement of these aging-related abnormalities diff... |
### Instruction:
Does homocysteine induce the expression of C-reactive protein via NMDAr-ROS-MAPK-NF-κB signal pathway in rat vascular smooth muscle cells?
### Response:
| The present study demonstrates that Hcy is able to initiate an inflammatory response in VSMCs by stimulating CRP production, which is mediated through NMDAr-ROS-ERK1/2/p38-NF-κB signal pathway. These findings provide new evidence for a role of Hcy in pathogenesis of atherosclerosis. |
### Instruction:
Do intraoperative complications have a negative impact on postoperative outcomes after rectal cancer surgery?
### Response:
| We found that intraoperative complications during rectal cancer surgery significantly prolonged hospital length stay. The overall morbidity rate was not affected. |
### Instruction:
Does glutathione S-transferase P1 ( GSTP1 ) directly influence platinum drug chemosensitivity in ovarian tumour cell lines?
### Response:
| Glutathione S-transferase P1 has an important role in cisplatin and carboplatin metabolism in ovarian cancer cells. Inter-tumour differences in GSTP1 expression may therefore influence response to platinum-based chemotherapy in ovarian cancer patients. |
### Instruction:
Does intraoperative angiography provide objective assessment of skin perfusion in complex knee reconstruction?
### Response:
| Implementation of LA-ICGA provides an objective intraoperative assessment of soft tissue perfusion. This technology may help guide the surgeon's decisions about wound closure in real-time to accommodate the perfusion challenges unique to each patient. Specifically, patients with medical risk factors for poor perfusion ... |
### Instruction:
Do anti-inflammation effects of naloxone involve phosphoinositide 3-kinase delta and gamma?
### Response:
| PI3Kδ and PI3Kγ play crucial roles in mediating the anti-inflammation effects of naloxone. |
### Instruction:
Is depression in mild cognitive impairment associated with progression to Alzheimer 's disease : a longitudinal study?
### Response:
| Depressive symptoms in MCI appear to be predictors for progression to AD. |
### Instruction:
Do branched-chain amino acid granules improve the non-protein respiratory quotient after radiofrequency ablation?
### Response:
| Supplementation with BCAA granules improves energy metabolism in addition to the liver function after RFA. Improvements in the liver function may result in consistently adequate treatment for HCC recurrence after RFA. |
### Instruction:
Does tumour regression grading after chemoradiotherapy for locally advanced rectal cancer : a near pathologic complete response translate into good clinical outcome?
### Response:
| The high number of near-pCR with ypT3 or ypN1/2 and their poor outcome demonstrates that "watch-and-wait" in LARC patients should be applied with care. |
### Instruction:
Does inkjet-based biopatterning of SDF-1β augment BMP-2-induced repair of critical size calvarial bone defects in mice?
### Response:
| Our data indicates that sustained release delivery of a low-dose growth factor therapy using biopatterning technology can aid in healing CSD injuries. SDF-1β augments the ability for BMP-2 to drive healing, a result confirmed in vivo and in vitro; however, because SDF-1β is detrimental to TGF-β1-driven osteogenesis, it... |
### Instruction:
Does surgeon-Performed Ultrasound-Guided Fine-Needle Aspiration Cytology ( SP-US-FNAC ) shorten Time for Diagnosis of Thyroid Nodules?
### Response:
| In the workup of thyroid nodules, SP-US-FNAC is as accurate as RP-US-FNAC but significantly reduces the time taken to reach a cytological diagnosis. This leads to greater clinical efficiency in the management of patients with thyroid nodules, which in turn leads to other benefits such as decreased patient anxiety and i... |
### Instruction:
Are difficulties in emotion regulation associated with panic symptom severity following a quit attempt among cannabis dependent veterans?
### Response:
| RESULTS are discussed in terms of integrating adaptive emotion regulation skills training into existing evidence-based treatments for cannabis dependence. |
### Instruction:
Does the percent change of strain and strain rate under dobutamine stress echocardiography predict viability following myocardial infarction?
### Response:
| In patients undergoing viability assessment following ST segment elevation myocardial infarction, the percent change of both S and SR (from baseline to dobutamine-induced values) was significantly higher in viable versus non-viable segments. A cut-off value of 20-25% of the percent change for both S and SR reliably ide... |
### Instruction:
Do diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate?
### Response:
| Diets rich in saturated and/or polyunsaturated fatty acids induced overweight. Independently of insulin resistance, polyunsaturated fatty acids increased prostate stromal and epithelial cell proliferation. Saturated fatty acids influenced only stromal cellular proliferation. These structural and morphometric alteration... |
### Instruction:
Does norepinephrine stimulate mobilization of endothelial progenitor cells after limb ischemia?
### Response:
| These results unravel that sympathetic nervous system regulate EPCs mobilization and their pro-angiogenic capacity via α adrenoceptor, β 2 adrenoceptor and meanwhile Akt/eNOS signaling pathway. |
### Instruction:
Is serum total p-cresylsulfate level associated with abnormal QTc interval in stable angina patients with early stage of renal failure?
### Response:
| This study indicates that serum total PCS levels are significantly higher in the presence of abnormal QTc interval and are associated with the QTc prolongation. Whether total PCS plays a role in the pathogenesis of QTc prolongation requires future investigation. |
### Instruction:
Is breast-conserving surgery contraindicated for recurrent giant multifocal phyllodes tumours of breast?
### Response:
| Large size, multifocality, and borderline or malignant histology are contraindications for breast-conserving surgery. |
### Instruction:
Are markers of inflammation and activation of coagulation associated with anaemia in antiretroviral-treated HIV disease?
### Response:
| Persistent inflammation and hypercoagulation appear to be associated with anaemia. Routine measurements of haemoglobin might provide insights into the inflammatory state of treated HIV infection. |
### Instruction:
Do sanpao herbs inhibit development of atopic dermatitis in Balb/c mice?
### Response:
| SPC has beneficial effects when used in the treatment of chronic dermatitis-eczema in mice. |
### Instruction:
Are p53 and nitric oxide involved in cytokine-induced apoptosis in Kasumi-1 and Molt-4 Leukemics cells?
### Response:
| p53 and nitric oxide are involved in the mediation of apoptosis induced by cytokines in Kasumi-1 and Molt-4 leukemic cell lines. |
### Instruction:
Do subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline?
### Response:
| The results demonstrated that a fifty-fold lower dose of 17DD-YF vaccine (587 IU) is able to trigger similar immunogenicity, as evidenced by significant titers of anti-YF PRNT. However, only subdoses as low as 3,013 IU elicit viremia kinetics with an early peak at five days after primary vaccination equivalent to the c... |
### Instruction:
Does laparoscopy mitigate adverse oncological effects of delayed adjuvant chemotherapy for colon cancer?
### Response:
| The benefits of quicker recovery after laparoscopic surgery did not translate into earlier initiation of adjuvant chemotherapy in this retrospective study. However, a laparoscopic approach negated the inferior oncologic outcomes of patients who received delayed initiation of chemotherapy. |
### Instruction:
Does a preoperative hernia symptom score predict inguinal hernia anatomy and outcomes after TEP repair?
### Response:
| Pre- and post-operative scoring of hernia specific symptoms should be considered as part of routine surgical practice, to counsel patients on their expectations of pain and discomfort post repair and to select those who might be more appropriate for a watchful waiting approach. Females with inguinal hernia warrant comp... |
### Instruction:
Are ascaris lumbricoides infection and parasite load associated with asthma in children?
### Response:
| In children living in urban areas of low socioeconomic status, a light parasite load of A. lumbricoides is a protective factor against asthma and its symptoms. Meanwhile, heavy parasite load is a risk factor and contributes to the high prevalence of asthma and its symptoms among these children. |
### Instruction:
Do f-actin-anchored focal adhesions distinguish endothelial phenotypes of human arteries and veins?
### Response:
| Our data show that F-actin-anchored focal adhesions distinguish endothelial phenotypes of human arteries from veins. We conclude that the biomechanical properties of the vascular extracellular matrix determine this endothelial characteristic. |
### Instruction:
Is retinal vasculopathy reduced by dietary salt restriction : involvement of Glia , ENaCα , and the renin-angiotensin-aldosterone system?
### Response:
| An LS diet reduced retinal vasculopathy, by modulating glial cell function and the retinal renin-angiotensin-aldosterone system. |
### Instruction:
Does hOXA9 promote homotypic and heterotypic cell interactions that facilitate ovarian cancer dissemination via its induction of P-cadherin?
### Response:
| These findings indicate that HOXA9 contributes to poor outcomes in EOC in part by promoting intraperitoneal dissemination via its induction of P-cadherin. |
### Instruction:
Is gene expression in peripheral immune cells following cardioembolic stroke sexually dimorphic?
### Response:
| There are sexually dimorphic immune cell expression profiles following cardioembolic stroke. Future studies are needed to confirm the findings using qRT-PCR in an independent cohort, to determine how they relate to risk and outcome, and to compare to other causes of ischemic stroke. |
### Instruction:
Do interpersonal stressors predict ghrelin and leptin levels in women?
### Response:
| These data suggest that ghrelin and leptin may link daily interpersonal stressors to weight gain and obesity. |
### Instruction:
Do novel Cul3 binding proteins function to remodel E3 ligase complexes?
### Response:
| Our study identified a new set of Cul3-binding proteins known as CLWs via tandem affinity purification and LC/MS-MS analysis. Subsequently, our biochemical analysis revealed that some CLWs modify binding of BTB domain-containing proteins to the complex, causing degradation of the BTB domain-containing protein. As these... |
### Instruction:
Does low-dose clarithromycin therapy modulate Th17 response in non-cystic fibrosis bronchiectasis patients?
### Response:
| Our results argue for a reduction of both systemic and local Th17 response after prophylactic, low-dose clarithromycin administration in patients with non-CF bronchiectasis, suggestive of a potential anti-inflammatory and/or immunomodulatory action. |
### Instruction:
Does genomic prostate cancer classifier predict biochemical failure and metastases in patients after postoperative radiation therapy?
### Response:
| The GC predicted BF and metastasis after post-RP irradiation. Patients with lower GC risk may benefit from delayed RT, as opposed to those with higher GC; however, this needs prospective validation. Genomic-based models may be useful for improved decision-making for treatment of high-risk prostate cancer. |
### Instruction:
Does g protein-coupled estrogen receptor regulate mammary tumorigenesis and metastasis?
### Response:
| This is the first description of a role for the novel estrogen receptor GPER in breast tumorigenesis and metastasis, demonstrating that it represents a new target in breast cancer diagnosis, prognosis, and therapy. |
### Instruction:
Does short-term treatment result for unilateral vocal fold palsy induced by mediastinal lesions?
### Response:
| Mediastinal lesion-induced UVFP is associated with a larger glottal gap than that caused by an injury induced by thyroidectomy. Despite large glottal gap, injection laryngoplasty improves voice outcomes in such types of UVFP. |
### Instruction:
Are urinary metabolic profiles in early pregnancy associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study?
### Response:
| Urinary metabolites measured at the end of the first trimester are associated with increased risk of negative birth outcomes, and provide novel information about the possible mechanisms leading to adverse pregnancies in the Rhea cohort. This study emphasizes the potential of metabolic profiling of urine as a means to i... |
### Instruction:
Does restoration of miR-193b sensitize Hepatitis B virus-associated hepatocellular carcinoma to sorafenib?
### Response:
| Modulation of miRNAs expression might be a potential way to enhance response to sorafenib in HBV-associated HCC. |
### Instruction:
Is renal function associated with bone mineral density and arterial stiffness in healthy postmenopausal women?
### Response:
| Postmenopausal women with decreased renal function are more likely to have a decreased BMD and greater arterial stiffness. |
### Instruction:
Are plasma β-amyloid 40 levels positively associated with mortality risks in the elderly?
### Response:
| Further investigations are needed to determine precisely the pathophysiological roles of plasma Aβ1-40 and cystatin C and before envisioning any future clinical applications. |
### Instruction:
Does deletion of Cd151 reduce mammary tumorigenesis in the MMTV/PyMT mouse model?
### Response:
| The findings from this study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes and strongly support its relevance as a potential therapeutic target to delay breast cancer progression. |
### Instruction:
Is refractory hyperaldosteronism in heart failure associated with plasma renin activity and angiotensinogen polymorphism?
### Response:
| In conclusion, refractory hyperaldosteronism in heart failure may be influenced by AGT M235T polymorphism, among RAAS candidate genes, and by PRA, which may represent, respectively, a constitutive (genotype dependent) and a nongenetic (phenotype-dependent) trigger for aldosterone elevation. |
### Instruction:
Does danning tablets attenuate α-naphthylisothiocyanate-induced cholestasis by modulating the expression of transporters and metabolic enzymes?
### Response:
| DNts might promote bile acid and bilirubin elimination by regulating the expressions of hepatic and renal transporters as well as hepatic metabolic enzymes. |
### Instruction:
Does simulated hypoxia further improve aerobic capacity during sprint interval training?
### Response:
| Hypoxic and normoxic SIT caused improvement in V̇O2peak and TTE compared to a control. Hypoxic SIT did not cause further improvements, indicating hypoxia based SIT offers no additional benefit for improvement of endurance performance. |
### Instruction:
Does surgical revascularization in structural orthotopic bone allograft increase bone remodeling?
### Response:
| Surgical revascularization of large segmental allografts improved bone remodeling and viability without an adverse effect on total bone volume or bending strength and stiffness in this short-term analysis. |
### Instruction:
Does influence of secreted frizzled receptor protein 1 ( SFRP1 ) on neoadjuvant chemotherapy in triple negative breast cancer rely on WNT signaling?
### Response:
| We could firstly show that SFRP1 strongly correlates with the triple negative breast cancer subtype and secondly, that SFRP1 might be used as a marker stratifying patients to positively respond to neoadjuvant chemotherapy. The mechanisms by which tumor suppressor SFRP1 influences carcinogenic properties of cancer cells... |
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