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### Instruction:
Is hyponatremia a surrogate marker of poor outcome in peritoneal dialysis-related peritonitis?
### Response:
| In uremic patients with PDRP, hyponatremia at admission associated with a high frequency of gram negative bacilli infection, low serum albumin and phosphate levels, low SGA score, and poor prognosis with long hospital stay and high mortality rate. |
### Instruction:
Are eR stress and ER stress-induced apoptosis activated in gastric SMCs in diabetic rats?
### Response:
| ER stress and ER stress-mediated apoptosis are activated in gastric SMCs in diabetic rats with gastroparesis. |
### Instruction:
Does contribution of individual risk factor change to reductions in population absolute cardiovascular risk?
### Response:
| Approximately 59% of the modifiable risk attributable to the combination of high blood pressure, high cholesterol, and current smoking was removed after intervention. |
### Instruction:
Are rapid increases in infant adiposity and overweight/obesity in childhood associated with higher central and brachial blood pressure in early adulthood?
### Response:
| Small size at birth followed by rapid adiposity gain in infancy and continued overweight/obesity are associated with greater BP in young adulthood. These findings emphasize the importance of maintenance of normal weight in childhood for the prevention of high BP. |
### Instruction:
Is the blood pressure-lowering effect of renal denervation inversely related to kidney function?
### Response:
| The present explorative study shows an inverse relation between the BP-lowering effect of RDN and eGFR. Second, we found relations between variables of the RAAS and SNS with the BP-lowering effect of RDN. The data complement current concepts on pathophysiology of sympathetic hyperactivity and hypertension and may give ... |
### Instruction:
Is down-regulation of PERK-ATF4-CHOP pathway by Astragaloside IV associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats?
### Response:
| The protective effect of AS-IV on ER stress-induced podocyte apoptosis is associated with inhibition of PERK-ATF4-CHOP pathway. Down-regulation of PERK- ATF4-CHOP pathway by AS-IV may be a novel strategy for the treatment of DN. |
### Instruction:
Does external rotation of the femoral component decrease patellofemoral contact stress in total knee arthroplasty?
### Response:
| Regarding the alignment of the femoral component, only the rotational alignment of the femoral component was correlated with PF contact stress. PF contact stress decreased more as the femoral component rotated more externally. |
### Instruction:
Are magnetic resonance imaging-based tumour perfusion parameters biomarkers predicting response after radiation to brain metastases?
### Response:
| Lower Ktrans(2) at 1 week and rCBV at 1 month discriminated responders and progressive disease, respectively. |
### Instruction:
Is a potentially functional variant in the serotonin transporter gene associated with premenopausal and perimenopausal hot flashes?
### Response:
| Disruption of a microRNA binding site leads to higher expression of SLC6A4, higher expression of SLC6A4 leads to depletion of serotonin in synaptic clefts, and depletion of serotonin triggers the presynaptic autoreceptor feedback mechanism to produce more serotonin, which is protective against HFs. This is the first st... |
### Instruction:
Do cTLA4 variants and haplotype contribute genetic susceptibility to myasthenia gravis in northern Chinese population?
### Response:
| A predisposing effect of rs1863800*C, rs733618*C, and rs231775*G of CTLA4 gene to general risk of MG in Chinese was demonstrated for the first time, which was likely derived from EOMG, SPMG, MG without thymoma and the female patients. |
### Instruction:
Do hepatic inflammation scores correlate with common carotid intima-media thickness in rats with NAFLD induced by a high-fat diet?
### Response:
| We demonstrated that ultrasound imaging in the diagnosis of fatty liver disease and early atherosclerosis in rats is feasible and efficient, and that carotid IMT increased significantly in NASH rats but not in simple steatotic rats. A significant correlation between the IMT of the carotid artery with hepatic inflammati... |
### Instruction:
Do common flaws exist in published cost-effectiveness models of pharmacologic stroke prevention in atrial fibrillation?
### Response:
| Pharmacologic SPAF cost-effectiveness models have been extensively reported, but many may have flaws giving reason for decision makers to use caution. We provide 10 recommendations to avoid common flaws in SPAF cost-effectiveness models. |
### Instruction:
Is [ Imbalance between Th1 and Th2 cells in cord blood influenced by maternal allergic rhinitis and associated with atopic dermatitis during the first two years of life ]?
### Response:
| Elevated IL-4⁺CD4⁺ T cells in cord blood were of relevance with maternal allergic history. Imbalance between Th1 cell and Th2 cell at birth are associated with maternal allergy and promoted subsequent AD development. |
### Instruction:
Are protective antioxidative effects of caffeic acid phenethyl ester ( CAPE ) in the thyroid and the liver similar to those caused by melatonin?
### Response:
| Protective antioxidative effects of CAPE in the thyroid and the liver are similar to those caused by melatonin. CAPE constitutes a promising agent in terms of its application in experimental and, possibly, clinical studies. |
### Instruction:
Is dietary zinc associated with a lower incidence of depression : findings from two Australian cohorts?
### Response:
| Dietary assessment was carried out only at baseline and although adjustments were made for all known potential confounders, residual confounding cannot be entirely excluded. |
### Instruction:
Are arginase I levels decreased in the plasma of pediatric patients with atopic dermatitis?
### Response:
| In AD, a different mechanism of arginine metabolism seems to be stimulated, leading to the formation of nitric oxide pathway components causing suppression of the arginase pathway and impairment in skin hydration, collagen synthesis, and wound healing. |
### Instruction:
Is histone deacetylase 8 deregulated in urothelial cancer but not a target for efficient treatment?
### Response:
| Deregulation of HDAC8 is frequent in urothelial cancer, but neither specific pharmacological inhibition nor siRNA-mediated knockdown of HDAC8 impaired viability of urothelial cancer cell lines in a therapeutic useful manner. Accordingly, HDAC8 on its own is not a promising drug target in bladder cancer. |
### Instruction:
Does childhood trauma associate with clinical features of bipolar disorder in a sample of Chinese patients?
### Response:
| Data on childhood trauma were derived from a retrospective self-report questionnaire without independent corroboration. A number of potential patients (more severe or chronic patients) was excluded because they were either refused to participate or inappropriate to participate in research. |
### Instruction:
Does use of hydrogel breast biopsy tissue markers reduce the need for wire localization?
### Response:
| Hydrogel biopsy tissue markers optimize the surgeon's ability to perform a partial mastectomy without the use of WL. HydroMARK was as effective as a standard marker in terms of partial mastectomy specimen volume and re-excision rate. This yields potential for cost savings, increased efficacy in operating room and radio... |
### Instruction:
Do the mitochondrial and chloroplast genomes of the haptophyte Chrysochromulina tobin contain unique repeat structures and gene profiles?
### Response:
| The Chrysochromulina tobin organellar genomes provide new insight into organellar function and evolution. These are the first organellar genomes to be determined for the prymnesiales, a taxon that is present in both oceanic and freshwater systems and represents major primary photosynthetic producers and contributors to... |
### Instruction:
Does pelvic incidence-lumbar lordosis mismatch predispose to adjacent segment disease after lumbar spinal fusion?
### Response:
| In degenerative disease of the lumbar spine a high pelvic incidence with diminished lumbar lordosis seems to predispose to adjacent segment disease. Patients with such pelvic incidence-lumbar lordosis mismatch exhibit a 10-times higher risk for undergoing revision surgery than controls if sagittal malalignment is maint... |
### Instruction:
Does whey peptide ingestion suppress body fat accumulation in senescence-accelerated mouse prone 6 ( SAMP6 )?
### Response:
| These data suggest that a normal (or moderate excess) dietary density of whey peptide attenuates body fat accumulation via upregulation of fatty acid oxidation in skeletal muscle in aging mice. |
### Instruction:
Does morphology of susceptibility vessel sign predict middle cerebral artery recanalization after intravenous thrombolysis?
### Response:
| Irregular shape and long length (>20 mm) of SVS decrease the potential to recanalize the occluded middle cerebral artery with intravenous thrombolysis. |
### Instruction:
Does von Willebrand factor drive the association between elevated factor VIII and poor outcomes in patients with ischemic stroke?
### Response:
| Concurrent FVIII/vWF elevation predicts higher odds of inpatient complications, neuroworsening, and worse functional outcomes for patients with AIS compared with patients with normal levels. Our findings suggest that FVIII and vWF levels may serve as clinically useful stroke biomarkers by providing risk profiles for pa... |
### Instruction:
Is high-speed resistance training more effective than low-speed resistance training to increase functional capacity and muscle performance in older women?
### Response:
| Both RT interventions are effective in improving functional capacity, muscle performance and quality of life in older women, although a high-speed RT program induces greater improvements in muscle power and functional capacity. |
### Instruction:
Do three-dimensional accuracy of a digitally coded healing abutment implant impression system?
### Response:
| Distortions were observed with both impression techniques. However, the results suggest that EN was less accurate than DI. |
### Instruction:
Does dietary enrichment with alpha-linolenic acid during pregnancy attenuate insulin resistance in adult offspring in mice?
### Response:
| The results observed using this novel model suggest that ALA in maternal diet may have the potential to inhibit insulin resistance in adult offspring. |
### Instruction:
Are nutritional parameters associated with mortality in acute kidney injury?
### Response:
| In acute kidney injury patients, a nutritional assessment seems to identify nutritional markers that are associated with outcome. In this study, a low caloric intake, higher C-reactive protein levels, the presence of edema, a lower resistance measured during a bioelectrical impedance analysis and a lower nitrogen balan... |
### Instruction:
Does a ( 90 ) Y-labelled anti-ROBO1 monoclonal antibody exhibit antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy?
### Response:
| These results suggest that RIT with (90)Y-anti-ROBO1 MAb is a promising treatment for ROBO1-positive hepatocellular carcinoma. |
### Instruction:
Is aberrant serum immunoglobulin G glycosylation in chronic hepatitis B associated with histological liver damage and reversible by antiviral therapy?
### Response:
| Aberrant serum IgG-Fc glycosylation in CHB, which is highly associated with histological liver damage, affects IgG opsonizing activity and can be reversed by antiviral therapy. |
### Instruction:
Are nonsteroidal anti-inflammatory drugs major causes of drug-induced anaphylaxis?
### Response:
| The prevalence of anaphylaxis is high in patients who seek medical assistance for drug reactions, but its diagnosis is missed in emergency services, and adrenaline is underused. Drugs were prescribed to many patients despite a history of previous reaction. Nonsteroidal anti-inflammatory drugs were implicated in most ca... |
### Instruction:
Are polymorphisms of SP110 associated with both pulmonary and extra-pulmonary tuberculosis among the Vietnamese?
### Response:
| SP110 variants were associated with increased susceptibility to both pulmonary and extra-pulmonary TB in the Vietnamese. Genetic variants in SP110 may influence macrophage signaling responses and apoptosis during M. tuberculosis infection, however further research is required to establish the mechanism by which SP110 i... |
### Instruction:
Does 4-Phenylbutyric acid increase GLUT4 gene expression through suppression of HDAC5 but not endoplasmic reticulum stress?
### Response:
| Our data indicate that 4-PBA increases GLUT4 expression by acetylating the MEF2 site to increase the MEF2A binding through a mechanism that involves suppression of the HDAC5 pathway, but without involving ER stress. |
### Instruction:
Is anemia independently associated with NT-proBNP levels in asymptomatic predialysis patients with chronic kidney disease?
### Response:
| The increased NT-proBNP levels in asymptomatic patients with advanced CKD were independently associated with echocardiographic parameters of LV function, but anemia may represent one of the important confounder of the relationship between NT-proBNP and cardiovascular abnormalities. |
### Instruction:
Does microRNA-205 regulate the calcification and osteoblastic differentiation of vascular smooth muscle cells?
### Response:
| The present study shows that miR-205 may negatively regulate the β-glycerophosphate-induced calcification of HASMCs, at least partially by targeting Runx2 and Smad1. |
### Instruction:
Is the murine appendiceal microbiome altered in spontaneous colitis and its pathological progression?
### Response:
| The appendiceal dysbiosis observed in our Winnie mice is commensurate with, and adds to extant literature data. The presence of Helicobacteraceae (Proteobacteria) only in colitic Winnie mice (but not control mice) is consistent with reports of increased Helicobacter in IBD patients. Bacteroides (Bacteroidetes) decrease... |
### Instruction:
Is mechanical thromboprophylaxis sufficient to prevent the lower extremity deep vein thrombosis after kidney transplantation?
### Response:
| The incidence of DVT in this study was relatively lower than that of western populations. We did not encounter a factor V Leiden mutation or a prothrombin gene 20210A mutation in our study population. These findings suggest that inherited thrombophilic risk factors may be partially responsible for the difference in DVT... |
### Instruction:
Does prospective nationwide fluoroscopic and electrical longitudinal follow-up of recalled Riata defibrillator lead in Denmark?
### Response:
| The development of EC is a dynamic process despite long lead dwell time. ECs are associated with a higher risk of electrical abnormalities. Therefore, lead replacement should be considered, especially in patients with a long life expectancy. |
### Instruction:
Do electromagnetic fields affect bone micro-architecture in osteoporotic rats?
### Response:
| In this study we were unable to reproduce the strong beneficial findings reported by others. This might indicate that EMF treatment is very sensitive to the specific set-up, which would be a serious hindrance for clinical use. No evidence was found that EMF treatment can influence bone mass for the benefit of osteoporo... |
### Instruction:
Does sodium L-ascorbate enhance elastic fibers deposition by fibroblasts from normal and pathologic human skin?
### Response:
| Our results endorse the use of this potent stimulator of collagen and elastin production in the treatment of wrinkled and stretch-marked skin. They also encourage inclusion of SA into therapeutic combinations with collagenogenesis inhibitors to prevent formation of dermal scars and keloids. |
### Instruction:
Does targeting nucleophosmin 1 represent a rational strategy for radiation sensitization?
### Response:
| These data demonstrate that YTR107-mediated targeting of NPM1 impairs DNA DSB repair, an event that increases radiation sensitivity. |
### Instruction:
Do eRCC1 Cys8092Ala and XRCC1 Arg399Gln polymorphisms predict progression-free survival after curative radiotherapy for nasopharyngeal carcinoma?
### Response:
| The ERCC1 Cys8092Ala polymorphism is an independent predictor of response to radiotherapy for NPC, and the XRCC1 Arg399Glu mutation combined with smoking status seems to predict PFS as well. Our results further suggest a possible correlation between these genetic polymorphisms and p53 protein status on survival. |
### Instruction:
Does a Novel Cytosolic Isoform of Mitochondrial Trans-2-Enoyl-CoA Reductase enhance Peroxisome Proliferator-Activated Receptor α Activity?
### Response:
| We found the cytosolic form of MECR (cMECR) was expressed in the cytosolic and/or nuclear region, directly binds with PPARα, and enhances PPARα activity. |
### Instruction:
Is the ICAM-1 K469E polymorphism associated with the risk of coronary artery disease : a meta-analysis?
### Response:
| In conclusion, this meta-analysis suggested that the ICAM-1 K469E polymorphism was a risk factor for CAD. |
### Instruction:
Is α4 integrin a regulator of leukocyte recruitment after experimental intracerebral hemorrhage?
### Response:
| α4 integrin is an important cell adhesion molecule involved in neuroinflammation after ICH. |
### Instruction:
Is standard-dose intravenous tissue-type plasminogen activator for stroke better than low doses?
### Response:
| Our study suggests that standard-dose intravenous tPA for stroke had more favorable outcome without increasing the risk of symptomatic intracranial hemorrhage than low-dose tPA. For Asian people, 0.9 mg/kg should be the optimal dose of tPA to treat acute ischemic stroke. |
### Instruction:
Do impact of the 5008 monitor software update on total convective volume?
### Response:
| The 5008 dialysis monitor software update has meant a 13 % increase of total convective volume and a 3.5 % increase of total filtered blood. |
### Instruction:
Does novel diet-related mouse model of colon cancer parallel human colon cancer?
### Response:
| The diet-related mouse model of colon cancer parallels progression to colon cancer in humans, and should be uniquely useful in model studies of prevention and therapeutics. |
### Instruction:
Is prognostic significance of miR-34a in Ewing sarcoma associated with cyclin D1 and ki-67 expression?
### Response:
| By demonstrating its relationship with clinical outcome, we propose evaluation of miR-34a at diagnosis of EWS patients to allow early risk stratification. Validation of these results would nonetheless ultimately need a prospective assessment. |
### Instruction:
Does microvascular endothelial dysfunction predict the development of erectile dysfunction in men with coronary atherosclerosis without critical stenoses?
### Response:
| Coronary microvascular dysfunction is a predictor of the development of ED in men with coronary atherosclerosis without critical stenoses. This study underscores the systemic involvement of the endothelial function in vascular disease. |
### Instruction:
Do classic papillary thyroid carcinoma with tall cell features and tall cell variant have similar clinicopathologic features?
### Response:
| Classic PTCs with TCF showed a similar BRAF mutation rate and clinicopathologic features to TCVPTCs, but more aggressive characteristics than classic PTCs. |
### Instruction:
Are interferon regulatory factor 5 genetic variants associated with cardiovascular disease in patients with rheumatoid arthritis?
### Response:
| Our results reveal that IRF5 gene variants are associated with risk of CV events in patients with RA. |
### Instruction:
Is the high-sensitivity modified Glasgow prognostic score superior to the modified Glasgow prognostic score as a prognostic predictor in patients with resectable gastric cancer?
### Response:
| The HS-mGPS before surgery is a superior prognostic predictor in patients with gastric cancer. |
### Instruction:
Do collagen and hyaluronan at wound sites influence early polymicrobial biofilm adhesive events?
### Response:
| Our study suggests that the presence of collagen and/or hyaluronan at wound sites may be an important factor that influences the attachment and subsequent biofilm formation of notorious biofilm-formers, such as MRSA and P. aeruginosa. Understanding the kinetics of binding may aid in our comprehension of recalcitrant wo... |
### Instruction:
Does blood glucose fluctuation aggravate lower extremity vascular disease in type 2 diabetes?
### Response:
| Enhanced fluctuation in patients with type 2 diabetes may promote the occurrence and development of lower-extremity vascular diseases through aggravating vascular endothelial injury. |
### Instruction:
Does cluster of differentiation 24 monoclonal antibody induce apoptosis in the osteosarcoma cells?
### Response:
| The findings showed that anti-CD24 mAb targeting therapy provides a new avenue toward treating osteosarcoma. |
### Instruction:
Does reprogramming of tumor metabolism by targeting mitochondria improve tumor response to irradiation?
### Response:
| Taken together, these results indicate that in addition to intrinsic radiosensitivity parameters the tumor response to radiation will also depend on their metabolic rate of oxygen consumption. |
### Instruction:
Does crystal structure reveal conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab?
### Response:
| The conformation of amyloid-β antigen recognized by 3D6 is novel and distinct from other antibodies recognizing N-terminal epitopes. Our result provides the first report demonstrating structural conservation of antigen contact residues, and conformation of antigen recognized, between the parent murine antibody and its ... |
### Instruction:
Does [ Shenfu injection induce the apoptosis of prostate cancer PC-3 cells ]?
### Response:
| SF can inhibit the proliferation and induce the apoptosis of PC-3 cells, which may due to its upregulation of the p53 mRNA expression. |
### Instruction:
Do oestrogen receptors β1 and βcx have divergent roles in breast cancer survival and lymph node metastasis?
### Response:
| Our study reveals highly significant although antagonising roles of ERβ1 and ERβcx in breast cancer. Consequently, we suggest that the histopathological assessment of ERβ1 is of value as a prognostic and potentially predictive biomarker. |
### Instruction:
Does low junctional adhesion molecule A expression correlate with poor prognosis in gastric cancer?
### Response:
| Low JAM-A expression correlates with poor clinical outcome and promotes cell migration and invasion in gastric cancer. |
### Instruction:
Is co-overexpression of HER2/HER3 a predictor of impaired survival in breast cancer patients?
### Response:
| HER2/HER3 co-overexpression is significantly associated with impaired OS from diagnosis of metastatic disease in patients with HER2-positive metastatic breast cancer. Co-inhibition of HER2 and HER3 or the inhibition of HER2/HER3 hetero-dimerization may improve clinical outcome in this subgroup. |
### Instruction:
Does ibuprofen protect ventilator-induced lung injury by downregulating Rho-kinase activity in rats?
### Response:
| Ibuprofen attenuated high tidal volume induced pulmonary endothelial hyperpermeability. This protective effect was associated with a reduced Rho-kinase activity. |
### Instruction:
Is the detection of the methylated Wif-1 gene more accurate than a fecal occult blood test for colorectal cancer screening?
### Response:
| The detection of methylated Wif-1 in either S or U has a higher performance accuracy compared to guaiac FOBT for advanced colorectal neoplasia screening. Conversely, fecal microbiota dysbiosis detection was not more accurate. Blood and urine testing could be used in those individuals reluctant to undergo stool testing. |
### Instruction:
Does transplantation of SIRT1-engineered aged mesenchymal stem cells improve cardiac function in a rat myocardial infarction model?
### Response:
| Up-regulating SIRT1 expression could enhance the efficacy of aged MSCs-based therapy for MI as it relates to the amelioration of senescent phenotype and hence improved biological function of aged MSCs. |
### Instruction:
Does mutant phenotype analysis suggest potential roles for C-type natriuretic peptide receptor ( NPR-B ) in male mouse fertility?
### Response:
| The potential role of CNP signaling via the NPR-B receptor in male fertility appears to be mediated not through germ-cell development, but may be through maintenance of normal penile function. |
### Instruction:
Are circulating interleukin-6 levels associated with abdominal aortic aneurysm presence : a meta-analysis and meta-regression of case-control studies?
### Response:
| Circulating IL-6 levels are greater in patients with AAA than those in subjects without AAA, which suggest that greater circulating IL-6 levels are associated with AAA presence. As the mean AAA diameter and the proportion of men increase, circulating IL-6 levels in patients with AAA are respectively more and less great... |
### Instruction:
Do differences in ST-elevation and T-wave amplitudes reliably differentiate takotsubo cardiomyopathy from acute anterior myocardial infarction?
### Response:
| In patients with anterior ST-elevation and acute chest pain, lack of ST-elevation in lead V1 and ST-elevation amplitude <2mm in lead V2 suggests a TTC diagnosis. However, this criterion is not reliable enough in clinical practice to distinguish between TTC and anterior-STEMI patients. |
### Instruction:
Does oral fingolimod reduce glutamate-mediated intracortical excitability in relapsing-remitting multiple sclerosis?
### Response:
| Fingolimod selectively reduced intracortical facilitation, which is mainly mediated by glutamate. |
### Instruction:
Do dNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer?
### Response:
| We identified XPF and pMK2 as novel DNA-repair biomarkers for locoregionally-advanced HNC patients undergoing platinum-based induction chemotherapy prior to definitive chemoradiation. Our study provides insights for the use of DNA repair biomarkers in personalized diagnostics strategies. Further validation in a larger ... |
### Instruction:
Does his bundle activate faster than ventricular myocardium during prolonged ventricular fibrillation?
### Response:
| During prolonged VF the activation rate of the His bundle is faster than that of the VM. This suggests that the proximal conduction system, like the distal Purkinje system, may be an important driver during long duration VF and may be a target for interventional therapy. |
### Instruction:
Does high self-efficacy predict adherence to surveillance colonoscopy in inflammatory bowel disease?
### Response:
| SE, as measured by our validated scales, correlates with chart-adherence to surveillance colonoscopy. Our adherence model, which includes SE, predicts adherence with 74% certainty. An 8-item validated clinical questionnaire can be administered to assess whether patients in this population may require further interventi... |
### Instruction:
Does a novel agent with histone deacetylase inhibitory activity attenuate neointimal hyperplasia?
### Response:
| Together these observations identify a novel agent, MCT-3, with histone deacetylase inhibitory activity, able to inhibit NIH and identify a potential molecular mechanism responsible for these effects. Additional pre-clinical studies may be warranted to determine the potential clinical utility of this compound. |
### Instruction:
Is solar ultraviolet radiation necessary to enhance grapevine fruit ripening transcriptional and phenolic responses?
### Response:
| Results suggest that the UV-B radiation-specific signalling pathway is activated in the skin of grapes grown at mid-altitudes. The biosynthesis and accumulation of secondary metabolites, which are appreciated in winemaking and potentially confer cross-tolerance, were almost specifically triggered. This draws attention ... |
### Instruction:
Does exposure to a social stressor disrupt the community structure of the colonic mucosa-associated microbiota?
### Response:
| These data illustrate that stressor exposure can affect microbial populations, including the lactobacilli, that are closely associated with the colonic mucosa. Because the lactobacilli can have beneficial effects on human health, stressor-induced reductions of their population could have important health implications. |
### Instruction:
Is the ratio of estimated average glucose to fasting plasma glucose level superior to glycated albumin , hemoglobin A1c , fructosamine , and GA/A1c ratio for assessing β-cell function in childhood diabetes?
### Response:
| A measurement of the eAG/fPG ratio may provide helpful information for assessing β-cell function in pediatric patients with diabetes. |
### Instruction:
Do depression and pain impair daily functioning and quality of life in patients with major depressive disorder?
### Response:
| This was a cross-sectional study with a small sample size. |
### Instruction:
Does electroacupuncture attenuate mechanical allodynia by suppressing the spinal JNK1/2 pathway in a rat model of inflammatory pain?
### Response:
| Our findings indicate that EA alleviates inflammatory pain behavior, at least in part, by reducing COX-2 expression in the spinal cord via the JNK1/2 signaling pathway. Inactivation of the spinal JNK1/2 signal transduction pathway maybe the potential mechanism of EA's antinociception in the inflammatory pain model. |
### Instruction:
Is cardioprotection afforded by exercise training prior to myocardial infarction associated with autonomic function improvement?
### Response:
| Prior ET was effective in changing aerobic capacity, left ventricular morphology and function in rats undergoing MI. Furthermore, these cardioprotective effects were associated with attenuated cardiac autonomic dysfunction observed in trained rats. Although these cause-effect relationships can only be inferred, rather ... |
### Instruction:
Is intestinal intraepithelial lymphocyte cytometric pattern more accurate than subepithelial deposits of anti-tissue transglutaminase IgA for the diagnosis of celiac disease in lymphocytic enteritis?
### Response:
| Analysis of the IEL flow cytometric pattern is a fast, accurate method for identifying CD in the initial diagnostic biopsy of patients presenting with lymphocytic enteritis, even in seronegative patients, and seems to be better than anti-TG2 intestinal deposits. |
### Instruction:
Does gABAA receptor agonist at the caudo-lateral peribrachial area suppress ponto-geniculo-occipital waves and its related states?
### Response:
| Acetylcholine promotes PGO related states (SP as well as REM sleep), while GABA reduces only SP and specifically PGOs. |
### Instruction:
Is immediate transverse rectus abdominis musculocutaneous flap reconstruction associated with improved cancer-specific survival in locally advanced breast cancer?
### Response:
| Immediate TRAM flap reconstruction is oncologically safe and is unassociated with delayed adjuvant therapies or delayed detection of local recurrence. Patients with locally advanced breast cancer can be considered appropriate candidates for TRAM flap reconstruction because the procedure is an independent predictor of b... |
### Instruction:
Is residual amount of HBV DNA in serum related to relapse in chronic hepatitis B patients after cessation of nucleos ( t ) ide analogs?
### Response:
| Residual amount of HBV DNA in serum at NA cessation is associated with HBV relapse. The cutoff value predicting relapse was 2.24 IU/mL, with a sensitivity of 0.553 and specificity of 0.840. |
### Instruction:
Is mYC amplification associated with poor survival in small cell lung cancer : a chromogenic in situ hybridization study?
### Response:
| MYC amplification is a frequent event in SCLC and is related to a short survival time. MYC amplification may be an independent prognostic factor for SCLC. Further studies are required to support this finding and clarify the role of MYC in SCLC tumorigenesis. |
### Instruction:
Do the effect of central vision loss on perception of mutual gaze?
### Response:
| Our results suggest that mutual gaze perception is relatively robust to CVL. However, a follow-up study that simulates less-than-optimal viewing conditions of everyday social interactions is needed. The gaze perception task holds promise as a research tool for investigating the effects of vision impairment on mutual ga... |
### Instruction:
Is deficiency of the ferrous iron transporter FeoAB linked with metronidazole resistance in Bacteroides fragilis?
### Response:
| Selection for feoAB mutations as a result of metronidazole treatment will disable the pathogenic potential of B. fragilis and could contribute to the clinical efficacy of metronidazole. While mutations in feoAB are probably not a direct cause of clinical resistance, this study provides a key insight into intracellular ... |
### Instruction:
Does hMGB1 promote the development of pulmonary arterial hypertension in rats?
### Response:
| Our results identify extracellular HMGB1 as a promoting factor for MCT-induced PAH. The blockade of HMGB1 activity improved survival of MCT-induced PAH rats, and thus might be a promising therapy for the treatment of PAH. |
### Instruction:
Does low magnification narrow band imaging by inexperienced endoscopists have a high accuracy in differentiation of colon polyp histology?
### Response:
| Low magnification NBI by inexperienced endoscopists has a high accuracy in predicting in vivo colorectal polyp histology encouraging its use in routine clinical practice. |
### Instruction:
Do successful conviction of intoxicated drivers at a level I trauma center?
### Response:
| Slightly more than half of drivers who present to an ED after a MVC receive a DUI conviction. The most severely injured subjects and those with lower BALs are least likely to be convicted of a DUI. |
### Instruction:
Is up-regulation of miR-630 in clear cell renal cell carcinoma associated with lower overall survival?
### Response:
| The study proves for the first time that miR-630 is upregulated in a majority of ccRCC patients. It also shows that miR-630 expression is an independent prognostic factor for patients with renal cancer, which might be a potential valuable biomarker for ccRCC. |
### Instruction:
Does genome-wide association identify regulatory Loci associated with distinct local histogram emphysema patterns?
### Response:
| This study demonstrates for the first time genetic associations with distinct patterns of pulmonary emphysema quantified by computed tomography scan. Enhancer regions are significantly enriched among these GWAS results, with pulmonary fibroblasts among the cell types showing the strongest enrichment. |
### Instruction:
Does aerobic exercise modulate intracortical inhibition and facilitation in a nonexercised upper limb muscle?
### Response:
| The current results demonstrate that the modulation of intracortical excitability following aerobic exercise is not limited to those muscles involved in the exercise, and that while exercise does not directly modulate the excitability of motor neurons, it may facilitate the induction of experience-dependent plasticity ... |
### Instruction:
Is carboplatin and paclitaxel treatment effective in advanced anal cancer?
### Response:
| Carboplatin and paclitaxel treatment shows encouraging activity in advanced SCCA. |
### Instruction:
Do deaf children with cochlear implants appear to use sentence context to help recognize spoken words?
### Response:
| The pattern of results suggests that some deaf children with CIs do not use sentence context to improve spoken word recognition. The inability to use sentence context may be due to possible interactions between language experience and cognitive factors that affect the ability to successfully integrate temporal-sequenti... |
### Instruction:
Does investigation of antiarthritic potential of Plumeria alba L. leave in acute and chronic models of arthritis?
### Response:
| The present study suggests that Plumeria alba L. has protective activity against arthritis and supports the traditional use of P. alba for rheumatism and other inflammatory diseases. |
### Instruction:
Does measurement of absolute copy number variation reveal association with essential hypertension?
### Response:
| Our data suggests that CNVs within regions identified in previous GWAS may play a role in human essential hypertension. |
### Instruction:
Does ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promote breast cancer metastasis through nuclear factor-кB mediated matrix metalloproteinase-1 gene regulation?
### Response:
| These results identify UEV1A as a potential therapeutic target in the treatment of metastasic breast cancers. |
### Instruction:
Do changes in liver cell DNA methylation status in diabetic mice affect its FT-IR characteristics?
### Response:
| Changes in DNA cytosine methylation levels induced by hyperglycemia in mouse liver cells produced changes in the respective DNA FT-IR profiles, revealing modifications to the vibrational intensities and frequencies of several chemical markers, including νas -CH3 stretching vibrations in the 5-methylcytosine methyl grou... |
### Instruction:
Does kisspeptin-54 trigger egg maturation in women undergoing in vitro fertilization?
### Response:
| This study demonstrates that a single injection of kisspeptin-54 can induce egg maturation in women with subfertility undergoing in vitro fertilization therapy. Subsequent fertilization of eggs matured following kisspeptin-54 administration and transfer of resulting embryos can lead to successful human pregnancy. |
### Instruction:
Does febuxostat ameliorate diabetic renal injury in a streptozotocin-induced diabetic rat model?
### Response:
| Febuxostat prevents diabetic renal injury such as albuminuria. This renoprotective effect appears to be due to attenuation of the inflammatory and oxidative effects of diabetes-induced renal damage through inhibition of XO and XDH activities. |
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