question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Is the basic social medical insurance associated with clinical outcomes in the patients with ST-elevation myocardial infarction : a retrospective study from Shanghai , China?
### Response:
| These results demonstrate that BSMI is closely associated with the major adverse events-free survival rate at 36-month follow-up in the STEMI patients under the current policies in Shanghai, China. |
### Instruction:
Are intraperitoneal and intravenous deliveries comparable in terms of drug efficacy and cell distribution in neonatal mice with hypoxia-ischemia?
### Response:
| This study demonstrated that the administration route influences the effects of drugs and cell distribution. Therefore, a preclinical study may need to be performed using the optimal administration route used in a clinical setting. |
### Instruction:
Does zn/Ga-DFO iron-chelating complex attenuate the inflammatory process in a mouse model of asthma?
### Response:
| In this mouse model of allergic asthma, Zn/Ga-DFO attenuated allergic airway inflammation. The beneficial effects of treatment were in accord with iron overload abatement in asthmatic lungs by Zn/Ga-DFO. The findings in both cellular and tissue levels supported the existence of a significant anti-inflammatory effect of... |
### Instruction:
Does silymarin alleviate bleomycin-induced pulmonary toxicity and lipid peroxidation in mice?
### Response:
| Silymarin attenuated bleomycin induced-pulmonary toxicity. This protective effect may be due to the ability of silymarin in keeping oxidant-antioxidant balance and regulating of inflammatory mediator release. |
### Instruction:
Is chronic lack of sleep associated with increased sports injuries in adolescent athletes?
### Response:
| Sleep deprivation and increasing grade in school appear to be associated with injuries in an adolescent athletic population. Encouraging young athletes to get optimal amounts of sleep may help protect them against athletic injuries. |
### Instruction:
Are small bowel adenocarcinomas complicating Crohn 's disease associated with dysplasia : a pathological and molecular study?
### Response:
| These results suggest that there is an inflammation-dysplasia-adenocarcinoma sequence in at least half of CD-related SBA, similar to what is observed in chronic colitis-related colorectal cancer and may have implications for the prevention and treatment of this cancer. |
### Instruction:
Does dosimetric and patient correlate of quality of life after prostate stereotactic ablative radiotherapy?
### Response:
| Long-term single-institution QOL outcomes are encouraging. Rigorous dosimetric constraints are needed to keep bothersome side effects low. |
### Instruction:
Is neuromuscular electrical stimulation via the peroneal nerve superior to graduated compression socks in reducing perceived muscle soreness following intense intermittent endurance exercise?
### Response:
| The novel NMES technique is superior to GCS in reducing PMS following intense intermittent endurance exercise. |
### Instruction:
Do effect of current pathway on mortality and morbidity in electrical burn patients?
### Response:
| Electrical injuries are mainly occupation-related injuries and in this research majority of injuries occurred outdoor by high voltage cables in young men. Thus the government should consider a distinct strategy for this group. Also it is observed that there were no significant differences in mortality and complications... |
### Instruction:
Does a crew resource management program tailored to trauma resuscitation improve team behavior and communication?
### Response:
| Crew Resource Management in the trauma resuscitation area enhances team dynamics, communication, and, ostensibly, patient safety. Philosophy and culture of CRM should be compulsory components of trauma programs and in resuscitation of injured patients. |
### Instruction:
Is measurement of shear wave velocity using acoustic radiation force impulse imaging hampered by previous use of ultrasound contrast agents?
### Response:
| ARFI showed excellent inter-observer reproducibility between 2 skilled physicians. UCA did not affect the measurement of SWV in both liver parenchyma and FLL, at least when performed 4 minutes after the contrast injection. ARFI may become an additional tool in the differential diagnosis of FLL. |
### Instruction:
Are plaques and tangles as well as Lewy-type alpha synucleinopathy associated with formed visual hallucinations?
### Response:
| These findings suggest that both AD and PD neuropathology contribute to the pathogenesis of VH. Incident VH could be predictive of concomitant AD/PD pathology even when criteria are not met for a second diagnosis. |
### Instruction:
Is mipomersen a promising therapy in the management of hypercholesterolemia : a meta-analysis of randomized controlled trials?
### Response:
| Mipomersen therapy is effective for lowering ApoB-containing lipoproteins in patients with severe hypercholesterolemia. Future studies exploring how to minimize side effects of mipomersen therapy are needed. |
### Instruction:
Does uV cross-linking of donor corneas confer resistance to keratolysis?
### Response:
| Collagen cross-linking of the deepithelialized anterior corneal surface for 30 minutes conferred optimal resistance to in vitro keratolysis by collagenase A. |
### Instruction:
Does automatic sleep classification using a data-driven topic model reveal latent sleep states?
### Response:
| Statistics of the latent sleep state content showed accordances to the sleep stages defined in the golden standard. However, this study indicates that sleep contains six diverse latent sleep states and that state transitions are continuous processes. |
### Instruction:
Is osteoprotegerin independently associated with metabolic syndrome and microvascular complications in type 2 diabetes mellitus?
### Response:
| Higher OPG levels were associated with risk of MS and microvascular complications. Studies are needed to test whether OPG could be a useful biomarker identifying patients at risk of vascular complications and whether further exploration of this pathway may lead novel therapeutic options. |
### Instruction:
Does mR angiography demonstrate a positive correlation between placental blood vessel volume and fetal size?
### Response:
| Interestingly, we found a positive correlation between FPBV and fetal size. Fetal size was measured in fetal weight and fetal head circumference. Fetal length did not correlate with FPBV. Further studies are warranted to investigate this relationship in pregnancies with intrauterine growth restriction, and whether MRI ... |
### Instruction:
Are penile torsion repair in children following a ladder step : simpler steps usually sufficient?
### Response:
| A ladder step approach is a good option for penile torsion repair, starting with simpler techniques until complete correction is achieved. There is no need to plan a complex procedure in advance. |
### Instruction:
Are cardiorespiratory fitness and visceral fat key determinants of serum fibroblast growth factor 21 concentration in Japanese men?
### Response:
| CRF and VFA are key determinants of the circulating FGF21 concentration. |
### Instruction:
Do biomarker progressions explain higher variability in stage-specific cognitive decline than baseline values in Alzheimer disease?
### Response:
| For most biomarkers, biomarker progressions explained higher variability in cognitive decline than biomarker baseline values. This has important implications for clinical trials targeted to modify AD biomarkers. |
### Instruction:
Do impaired corticopontocerebellar tracts underlie pseudobulbar affect in motor neuron disorders?
### Response:
| PBA is common in PLS. Imaging findings showing disruption of corticopontocerebellar pathways support the hypothesis that PBA can be viewed as a "dysmetria" of emotional expression resulting from cerebellar dysmodulation. |
### Instruction:
Do global copy number analyses by next generation sequencing provide insight into pig genome variation?
### Response:
| Our studies lay out one way for characterization of CNVs in the pig genome, provide insight into the pig genome variation and prompt CNV mechanisms studies when using pigs as biomedical models for human diseases. |
### Instruction:
Are p-wave dispersion and maximum duration independently associated with insulin resistance in metabolic syndrome?
### Response:
| This study suggests that patients with MS have a prolonged PWD and Pmax. The increase in these parameters may be an indicator for identification of patients at an increased risk for atrial fibrillation. |
### Instruction:
Is benefit of cup medialization in total hip arthroplasty associated with femoral anatomy?
### Response:
| The benefit of cup medialization is variable and depends on the individual anatomy. |
### Instruction:
Is hyperinflammation , rather than hemophagocytosis , the common link between macrophage activation syndrome and hemophagocytic lymphohistiocytosis?
### Response:
| Emerging evidence suggests hypercytokinemia is the driving cause of immunopathology and morbidity/mortality in hyperinflammatory syndromes. Therefore, approaches to block cytokine function may be fruitful in treating hyperinflammatory syndromes with less toxicity than current therapies. However, not all hyperinflammato... |
### Instruction:
Does norcantharidin induce growth inhibition and apoptosis of glioma cells by blocking the Raf/MEK/ERK pathway?
### Response:
| Our findings demonstrate that norcantharidin is effective for growth inhibition of glioma cell lines and suggest that norcantharidin may be a new therapeutic option for patients with glioma. |
### Instruction:
Does effect of remission definition on healthcare cost savings estimate for patients with rheumatoid arthritis treated with biologic therapies?
### Response:
| The magnitude of the healthcare cost savings varies according to the remission definition used in classifying patient disease status. The highest point estimate for cost savings was observed in patients attaining SDAI remission and the least with the CDAI; confidence intervals for these estimates do overlap. Future pha... |
### Instruction:
Is tacrolimus induction followed by maintenance monotherapy useful in selected patients with moderate-to-severe ulcerative colitis refractory to prior treatment?
### Response:
| Oral monotherapy with tacrolimus may be a valuable long-term therapeutic option in selected patients with moderate-to-severe active refractory ulcerative colitis. |
### Instruction:
Do evaluation of pars plana sclera fixation of posterior chamber intraocular lens?
### Response:
| Modified sutured PCIOL implantation is a safe, effective, and feasible technique for the correction of aphakia in eyes without adequate posterior capsular support. |
### Instruction:
Are serum mannose-binding lectin and C-reactive protein potential biomarkers for patients with community-acquired pneumonia?
### Response:
| Both the MBL and CRP can serve as inflammatory markers in predicting the outcome of patients with CAP. |
### Instruction:
Is severity of rhinovirus infection in hospitalized adults unrelated to genotype?
### Response:
| Infection with RV-A or RV-B was associated with greater severity of illness in our adult population; however, the association disappeared after controlling for confounders. |
### Instruction:
Does total arsenic screening prior to fractionation enhance clinical utility and test utilization in the assessment of arsenic toxicity?
### Response:
| A total arsenic screen before fractionation reduces the number of samples requiring fractionation by more than 91%, supporting the use of a screen with a reflex-to-fractionation approach for urine arsenic. |
### Instruction:
Does 9p21.3 risk locus is associate with first-ever myocardial infarction in an Austrian cohort?
### Response:
| These results are in line with the previous findings, suggesting that genetic information on the rs1333049 variant might be a useful predictor of adverse cardiac events. Thus, we could successfully replicate the predictive value of the 9p21 risk allele in an Austrian cohort. |
### Instruction:
Is 18F-FDG-PET/CT of limited value in primary staging of early stage cervical cancer?
### Response:
| Pathologic validation of 18F-FDG-PET/CT imaging demonstrates little value for 18F-FDG-PET/CT in patients with early stage (FIGO stage 1a–1b1) MRI-defined lymph node negative cervical carcinoma. Since the likelihood of metastatic nodal disease is very low in women with stage 1a–1b1 cervical cancer, we believe that 18F-F... |
### Instruction:
Do distinct miRNA signatures associate with subtypes of cholangiocarcinoma from infection with the tumourigenic liver fluke Opisthorchis viverrini?
### Response:
| We show that common histologic grades and subtypes of ICC have distinct miRNA profiles. As histological grade and subtypes are associated with ICC aggressiveness, these profiles could be used to enhance the early detection and improve the personalised treatment for ICC. These findings also suggest the involvement of sp... |
### Instruction:
Does compliance with surgical follow-up influence fistula maturation in a county hospital population?
### Response:
| In this indigent population, follow-up does not influence maturation rates of AVF. Despite poor compliance with follow-up in the setting of a public hospital, the maturation rate of an aggressive fistula-first approach is acceptable. |
### Instruction:
Does deliberate apprenticeship in the Pediatric Emergency Department improve experience for third-year students?
### Response:
| DA constitutes a feasible approach to the clinical learning environment that increases students' patient care experiences and may ease transitioning for undergraduate medical students to new clinical environments. |
### Instruction:
Does inhalation of ultrafine carbon particles alter heart rate and heart rate variability in people with type 2 diabetes?
### Response:
| Inhalation of elemental carbon ultrafine particles alters heart rate and heart rate variability in people with type 2 diabetes. Our findings suggest that effects may occur and persist hours after a single 2-hour exposure. |
### Instruction:
Does effect of ethanolic extract of Acacia auriculiformis leave on learning and memory in rats?
### Response:
| The acetylcholinesterase inhibiting property of Acacia auriculiformis contributes to its memory enhancing potential. Further large scale studies are required to elucidate its benefits on cognitive function. This may offer a promising new option for the treatment of dementia and other cognitive deficits. |
### Instruction:
Does sources and correlate of sodium consumption in the first 2 years of life?
### Response:
| The key food sources of sodium for children younger than 2 years are those that contribute to the whole population's high salt burden and highlight the essential role governments and food industry must play to reduce salt in commonly consumed foods. |
### Instruction:
Does computational analysis identify a sponge interaction network between long non-coding RNAs and messenger RNAs in human breast cancer?
### Response:
| Our study highlights a marked rewiring in the ceRNA program between normal and pathological breast tissue, documented by its "on/off" switch from normal to cancer, and vice-versa. This mutually exclusive activation confers an interesting character to ceRNAs as potential oncosuppressive, or oncogenic, protagonists in ca... |
### Instruction:
Does thioredoxin-interacting protein mediate hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo?
### Response:
| TXNIP mediates hepatic lipogenesis via PRMT1 and PGC-1α regulation and inflammation in vitro and in vivo, implying that targeting TXNIP and PRMT1 is a potential therapeutic approach for treatment of NAFLD. |
### Instruction:
Are surfactant protein-D-encoding gene variant polymorphisms linked to respiratory outcome in premature infants?
### Response:
| These findings extend and validate previous observations of SFTPD association with the risk of respiratory outcomes and suggest SFTPD as an essential factor affecting pulmonary adaptation in premature infants. |
### Instruction:
Does intrathecal administration of mesenchymal stem cells reduce the reactive oxygen species and pain behavior in neuropathic rats?
### Response:
| These results suggest that rMSCs may modulate neuropathic pain generation through ROS expression after spinal nerve ligation. |
### Instruction:
Does bupivacaine-induced Vasodilation be Mediated by Decreased Calcium Sensitization in Isolated Endothelium-denuded Rat Aortas Precontracted with Phenylephrine?
### Response:
| Taken together, these results suggest that toxic-dose bupivacaine-induced vasodilation appears to be mediated by decreased calcium sensitization in endothelium-denuded aortas precontracted with phenylephrine. In addition, potassium channel inhibitors had no effect on bupivacaine-induced relaxation. Toxic-dose bupivacai... |
### Instruction:
Does the grey matter correlate of impaired decision-making in multiple sclerosis?
### Response:
| These data clarify the features of decision-making deficits in MS, and provide the first evidence that they relate to grey and white matter abnormalities seen using MRI. |
### Instruction:
Are velocities of weight , height and fat mass gain during potentially critical periods of growth decisive for adult body composition?
### Response:
| Faster gain in weight and body fat during mid-childhood and puberty appear to be particularly relevant for adult fat mass. |
### Instruction:
Is short duration of sleep associated with elevated high-sensitivity C-reactive protein level in Taiwanese adults : a cross-sectional study?
### Response:
| In this study of healthy Taiwanese adults, short duration of sleep was significantly associated with elevated hs-CRP levels. Activation of pro-inflammatory pathways might represent a mechanism by which short sleep duration affects health. |
### Instruction:
Do crack/cocaine users show more family problems than other substance users?
### Response:
| Brazilian treatment programs should enhance family treatment strategies, and childcare services need to be included. |
### Instruction:
Is sevelamer cost effective versus calcium carbonate for the first-line treatment of hyperphosphatemia in new patients to hemodialysis : a patient-level economic evaluation of the INDEPENDENT-HD study?
### Response:
| Data on hospitalizations was taken from a post hoc retrospective chart review of the patients included in the INDEPENDENT study. Patient quality of life or health utility was not included in the analysis. |
### Instruction:
Do genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia?
### Response:
| Genotyping for MTHFR, ABCB1, ABCC2, and TYMS polymorphisms may be useful in identifying patients at risk of increased MTX toxicity and the need for dose optimization before treatment initiation. |
### Instruction:
Is endogenous kisspeptin tone a critical excitatory component of spontaneous GnRH activity and the GnRH response to NPY and CART?
### Response:
| Our electrophysiology studies suggest that basal endogenous kisspeptin tone is not only essential for spontaneous GnRH neuronal firing, but it is also required for the net excitatory effects of other neuropeptides, such as CART or NPY antagonism, on GnRH neurons. Therefore, endogenous kisspeptin tone could serve as the... |
### Instruction:
Is yAP activation an early event and a potential therapeutic target in liver cancer development?
### Response:
| These results suggest that (i) YAP overexpression is an early event in rat and human liver tumourigenesis; (ii) it is critical for the clonal expansion of carcinogen-initiated hepatocytes and oval cells, and (iii) VP-induced disruption of the YAP-TEAD interaction may provide an important approach for the treatment of Y... |
### Instruction:
Does the aryl hydrocarbon receptor ligand omeprazole inhibit breast cancer cell invasion and metastasis?
### Response:
| AHR-active pharmaceuticals such as omeprazole that decrease breast cancer cell invasion and metastasis may have important clinical applications for late stage breast cancer chemotherapy. |
### Instruction:
Is anti-inflammatory effect of caffeine associated with improved lung function after lipopolysaccharide-induced amnionitis?
### Response:
| Caffeine promotes anti-inflammatory effects in the immature lung of prenatal LPS-exposed rat pups associated with improvement of Rrs, suggesting a protective effect of caffeine on respiratory function via an anti-inflammatory mechanism. |
### Instruction:
Is consumption of grapefruit associated with higher nutrient intakes and diet quality among adults , and more favorable anthropometrics in women , NHANES 2003-2008?
### Response:
| Consumption of grapefruit was associated with higher intakes of vitamin C, magnesium, potassium, dietary fiber, and improved diet quality. Grapefruit may provide a healthful option for adults striving to meet fruit recommendations. |
### Instruction:
Does sterile inflammation after lymph node transfer improve lymphatic function and regeneration?
### Response:
| Sterile inflammation is a potent method of augmenting lymphatic function and lymphangiogenesis after lymph node transplantation and is associated with maintenance of lymph node architecture. Induction of inflammation after transplantation is the most effective method and promotes maintenance of normal lymph node B- and... |
### Instruction:
Does rubber hand illusion highlight massive visual capture and sensorimotor face-hand remapping in a tetraplegic man?
### Response:
| Despite lesions that dramatically disconnect the access to sensory inputs and motor outputs our data suggests a strong visual capture of a rubber hand and a possible remapping of hand-face representations after the spinal lesion. We suggest that vision and brain plasticity may represent a supportive tool for motor reha... |
### Instruction:
Does carbamazepine attenuate inducible nitric oxide synthase expression through Akt inhibition in activated microglial cells?
### Response:
| Our findings showed that carbamazepine exerted selective inhibition on LPS-induced microglial iNOS expression through the down-regulation of Akt activation, and thus may play a pivotal role of anti-neuroinflammation in its therapeutic efficacy. |
### Instruction:
Do role of computed tomography ( CT ) scan in staging of cervical carcinoma?
### Response:
| Our findings show that CT scan does not reliably correlate with clinical FIGO staging of cervical cancer. However, it can detect urinary obstruction as well as nodal or distant metastases and thus improves the clinical FIGO staging. |
### Instruction:
Does mir-208 promote cell proliferation by repressing SOX6 expression in human esophageal squamous cell carcinoma?
### Response:
| These results suggest that miR-208 represents a potential onco-miR and participates in ESCC carcinogenesis by suppressing SOX6 expression. |
### Instruction:
Do the detection of macular analysis by SD-OCT for optic chiasmal compression neuropathy and nasotemporal overlap?
### Response:
| The inner macular parameters in the nasal hemiretina exhibited high diagnostic abilities to detect BA. The GCL+ was more affected than mRNFL. The characteristic pattern of mRNFL and GCL+ thinning was implicated in the anatomical architecture regarding the nasotemporal overlap of the crossed and uncrossed fibers around ... |
### Instruction:
Does histone deacetylase 9 repress cholesterol efflux and alternatively activated macrophages in atherosclerosis development?
### Response:
| We conclude that macrophage HDAC9 upregulation is atherogenic via suppression of cholesterol efflux and generation of alternatively activated macrophages in atherosclerosis. |
### Instruction:
Is transmembrane protein 55B a novel regulator of cellular cholesterol metabolism?
### Response:
| Here, we report identification of TMEM55B as a novel regulator of cellular cholesterol metabolism through the combination of gene expression profiling and functional studies. The findings highlight the value of an integrated genomic approach for identifying genes that influence cholesterol homeostasis. |
### Instruction:
Does glycation of fetal hemoglobin reflect hyperglycemia exposure in utero?
### Response:
| Thus, Glα may reflect hyperglycemic exposure during the last weeks of fetal development. Future studies will confirm Glα is a predictive biomarker of prenatally programmed lifetime metabolic health and disease. |
### Instruction:
Is penicillin skin testing a safe and effective tool for evaluating penicillin allergy in the pediatric population?
### Response:
| Penicillin skin testing was safe and effective in the evaluation of children with a history of penicillin allergy. |
### Instruction:
Do [ Anatomy study on the fixation technique of buttress plate in the posterior column of the acetabulum ]?
### Response:
| When using the fixation technique of acetabular posterior column plate, the angles of screw-posterior column are 40 degrees to 60 degrees, 60 degrees to 75 degrees, 75 degrees to 90 degrees and 90 degrees to the angle of parallel to the square area respectively on the region of outer 1/4,outer-middle 1/4,inner-middle 1... |
### Instruction:
Does dNA immunization of Mycobacterium tuberculosis resuscitation-promoting factor B elicit polyfunctional CD8 ( + ) T cell responses?
### Response:
| RpfB DNA immunization elicits polyfunctional CD8(+) T cell responses, suggesting that RpfB DNA immunization might induce protective immunity against tuberculosis. |
### Instruction:
Is the p38α MAPK function in osteoprecursors required for bone formation and bone homeostasis in adult mice?
### Response:
| Our data demonstrates that, in addition to early skeletogenesis, p38α is essential for osteoblasts to maintain their function in mineralized adult bone, as bone anabolism should be sustained throughout life. Moreover, our data also emphasizes that clinical development of p38 inhibitors should take into account their po... |
### Instruction:
Is type II collagen antibody response enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice?
### Response:
| CII conformational dependent antibody responses are common in RA and are likely to originate from rheumatoid joints but did not show a correlation with ACPA response. Importantly, the fine specificity of the anti-CII response is similar with CIA in monkeys and rodents where the recognized epitopes are conserved and hav... |
### Instruction:
Is endoscopic ligation ( `` Loop-And-Let-Go '' ) effective treatment for large colonic lipomas : a prospective validation study?
### Response:
| The results of this study confirm that "loop-and-let-go" technique is safe and efficacious treatment of large colonic lipomas. |
### Instruction:
Does prolonged administration of secretin to normal rats increase biliary proliferation and secretin-induced ductal secretory activity?
### Response:
| We have demonstrated that secretin stimulates both in vivo and in vitro biliary proliferation and secretin-stimulated ductal secretory activity in normal rats. We suggest that the stimulatory effect of secretin on biliary proliferation and secretion may be important for preventing biliary dysfunction during ductopenic ... |
### Instruction:
Is topical administration of lacritin a novel therapy for aqueous-deficient dry eye disease?
### Response:
| Lacritin is significantly reduced in the tears of SS patients. Topically administered lacritin has therapeutic potential for the treatment of aqueous-deficient dry eye disease. |
### Instruction:
Does tSG-6 protect corneal endothelium from transcorneal cryoinjury in rabbits?
### Response:
| Tumor necrosis factor-α stimulated gene/protein-6 protected corneal endothelial cells from transcorneal cryoinjury through suppression of inflammation. |
### Instruction:
Is leg length associated with lower values of inflammatory markers in older Chinese : The Guangzhou Biobank Cohort Study?
### Response:
| Factors enabling more early growth may also lead to changes in immunity that are associated with reduced CVD risk. |
### Instruction:
Do sleep complaints predict increases in resting blood pressure following marital separation?
### Response:
| In recently separated adults, greater sleep complaints may index increased risk for future increases in BP. This work helps pinpoint one potential mechanistic pathway linking marital separation with an important, health-relevant biological outcome. |
### Instruction:
Do soluble guanylyl cyclase activators increase the expression of tolerance to morphine analgesic effect?
### Response:
| These data suggested that sGC activators have a significant role in tolerance to the analgesic effect of morphine (Tab. 1, Fig. 4, Ref. 29). |
### Instruction:
Do serum suPAR levels help differentiate steroid resistance from steroid-sensitive nephrotic syndrome in children?
### Response:
| From ROC curve analysis, we demonstrated the significance of the suPAR level in predicting SRNS with a high specificity but low sensitivity. However, the clinical value of suPAR to predict steroid resistance and guide therapy remains to be investigated further. |
### Instruction:
Are changes in MEG resting-state networks related to cognitive decline in type 1 diabetes mellitus patients?
### Response:
| Altered RSN functional connectivity was found in T1DM patients depending on clinical status. Lower DMN functional connectivity was related to poorer cognitive functioning. These results indicate that functional connectivity may play a key role in T1DM-related cognitive dysfunction. |
### Instruction:
Are variants in genes encoding pyrophosphate metabolizing enzymes associated with Pseudoxanthoma elasticum?
### Response:
| Polymorphisms in ALP, ENPP1 and ANKH are important genetic risk factors contributing to PXE. |
### Instruction:
Does atrial natriuretic peptide locally counteract the deleterious effects of cardiomyocyte mineralocorticoid receptor activation?
### Response:
| ANP counter-regulates cardiac MR activation in hypertensive heart disease. An imbalance in cardiac ANP/GC-A (inhibition) and aldosterone/MR signaling (augmentation) favors adverse cardiac remodeling in chronic pressure overload. |
### Instruction:
Does access to transport for women with hypovolemic shock differ according to weeks of pregnancy?
### Response:
| Women at 24 weeks of pregnancy or more were given preference for ambulance transport even when signs of shock were equivalent. Policy-makers aiming to lower maternal mortality need to address transport issues regardless of the etiology of hemorrhage or week of pregnancy. |
### Instruction:
Are cell-free urinary microRNA-99a and microRNA-125b diagnostic markers for the non-invasive screening of bladder cancer?
### Response:
| The results revealed a unique microRNA expression signature in the urine supernatants of UCB patients for the development of molecular diagnostic tests. An effective cell-free urinary microRNA-based model was developed using a combined index of the levels of microRNA-99a and microRNA-125b to detect UCB with good discri... |
### Instruction:
Does the evaluation of the treatment result in patients with a small closed pneumothorax?
### Response:
| In conclusion, the conservative treatment of a small closed pneumothorax is effective in most cases. |
### Instruction:
Are maternity leave duration and full-time/part-time work status associated with US mothers ' ability to meet breastfeeding intentions?
### Response:
| Returning to work full-time before 3 months may reduce a mother's ability to meet her intention to breastfeed at least 3 months. Employer support for flexible work scheduling may help more women achieve their breastfeeding goals. |
### Instruction:
Do revisions of monoblock metal-on-metal THAs have high early complication rates?
### Response:
| Complications and reoperations occur frequently after revision for failed monoblock metal-on-metal THA (20% and 16%, respectively), and older patients appear to be at greater risk for complications after these revisions. Aseptic loosening, deep infection, and instability are all of great concern after revision and surg... |
### Instruction:
Are minorities less likely to receive autologous blood transfusion for major elective orthopaedic surgery?
### Response:
| Historically disadvantaged populations receive fewer autologous blood transfusions for elective orthopaedic surgery. Whether the differential use is attributable to patient preference or unequal access to this practice should be investigated further. |
### Instruction:
Are polymicrobial bloodstream infections in the neonatal intensive care unit associated with increased mortality : a case-control study?
### Response:
| The frequency and increased mortality emphasizes the clinical significance of polymicrobial bloodstream infections in the neonatal intensive care unit. Clinical awareness and focused research on neonatal polymicrobial infections is urgently needed. |
### Instruction:
Is structural integrity decreased in both Achilles tendons in people with unilateral Achilles tendinopathy?
### Response:
| Both Achilles tendons are structurally compromised in patients with unilateral Achilles tendinopathy. Future studies need to investigate whether these changes increase the risk of developing symptoms. |
### Instruction:
Does metabolic enrichment of omega-3 polyunsaturated fatty acids reduce the onset of idiopathic knee osteoarthritis in mice?
### Response:
| Reducing the systemic n-6:n-3 ratio does not slow idiopathic changes in cartilage, synovium, or bone associated with early-stage knee OA in mice. The anti-inflammatory and anti-catabolic effects of n-3 PUFAs previously reported for cartilage may be more evident at later stages of disease or in post-traumatic and other ... |
### Instruction:
Does edaravone protect against methylglyoxal-induced barrier damage in human brain endothelial cells?
### Response:
| These results indicate for the first time that edaravone is protective in carbonyl stress induced barrier damage. Our data may contribute to the development of compounds to treat brain endothelial dysfunction in carbonyl stress related diseases. |
### Instruction:
Does only very early oxygen therapy attenuate posthemorrhagic edema formation and blood-brain barrier disruption in murine intracerebral hemorrhage?
### Response:
| Very early oxygen therapy can attenuate edema formation and BBB disruption after ICH, but the brief therapeutic time window suggests that the translational potential is limited. |
### Instruction:
Is mental health the most important factor influencing quality of life in elderly left behind when families migrate out of rural China?
### Response:
| mental health is the most important factor influencing quality of life of elderly left behind when family members migrated out of rural China. Our study suggested a need to widely establish a general practitioner team for psychological intervention for improving rural elderly people's Quality of Life level, especially ... |
### Instruction:
Does rORα suppress proliferation of vascular smooth muscle cells through activation of AMP-activated protein kinase?
### Response:
| These results demonstrate that RORα inhibits vSMC proliferation through AMPK-induced mTOR suppression, and suggest that RORα is a therapeutic target for the cardiovascular diseases associated with vSMC proliferation. |
### Instruction:
Does intravenous Patient-controlled Analgesia have a Positive Effect on the Prognosis of Delirium in Patients Undergoing Orthopedic Surgery?
### Response:
| We recommend the use of IV-PCA for pain control and management of delirium in patients with postoperative delirium. |
### Instruction:
Are circulating irisin and glucose-dependent insulinotropic peptide associated with the development of polycystic ovary syndrome?
### Response:
| Although there is as yet no evidence for a causal link between irisin and/or GIP and PCOS, it is conceivable that irisin and GIP might contribute to the development of PCOS and may also represent novel PCOS biomarkers. |
### Instruction:
Are aPE1 polymorphisms associated with colorectal cancer susceptibility in Chinese Hans?
### Response:
| APE1 Asp148Glu is associated with increased CRC risk and smoking alters the association between XRCC1 Arg399Gln and CRC risk in the Chinese Han population. |
### Instruction:
Is t-box transcription factor brachyury associated with prostate cancer progression and aggressiveness?
### Response:
| Collectively, the present study suggests that Brachyury plays an important role in prostate cancer aggressiveness and points, for the first time, to Brachyury as a significant predictor of poor prostate cancer prognosis. Our work paves the way for future studies assessing Brachyury as a possible prostate cancer therape... |
### Instruction:
Is the antiproliferative response of indole-3-carbinol in human melanoma cells triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation?
### Response:
| This study identifies NEDD4-1 as a new I3C target protein, and that the I3C disruption of NEDD4-1 ubiquitination activity triggers the stabilization of the wild-type PTEN tumor suppressor to induce an antiproliferative response in melanoma. Mol Cancer Res; 12(11); 1621-34. ©2014 AACR. |
### Instruction:
Do antifungal and cytotoxicity activities of the fresh xylem sap of Hymenaea courbaril L. and its major constituent fisetin?
### Response:
| Naturally occurring fisetin can provide excellent starting points for clinical application and can certainly represent a therapeutic potential against fungal infections, because it showed in vitro antifungal activity and low toxicity on animal cells. |
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