Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
paragraph_index
int64
sec
string
p_has_citation
int64
cites
string
citeids
list
pmid
int64
cited_id
string
sentences
string
all_sent_cites
list
sent_len
int64
sentence_batch_index
int64
sent_has_citation
float64
qc_fail
bool
cited_sentence
string
cites_in_sentence
list
cln_sentence
string
is_cap
bool
is_alpha
bool
ends_wp
bool
cit_qc
bool
lgtm
bool
__index_level_0__
int64
5
DISCUSSION
1
41
[ "DDQ002C41", "DDQ002C42", "DDQ002C47", "DDQ002C47", "DDQ002C47" ]
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
As a functional J or J-like domain is essential for the formation of a stable heterodimer, we predict that the truncated protein is defective in forming a functional Magmas:DnaJC19 subcomplex and hence, the interaction of DnaJC19 with human TIM23 complex gets compromised.
[ "41", "42", "47", "47", "47" ]
272
37,416
0
false
As a functional J or J-like domain is essential for the formation of a stable heterodimer, we predict that the truncated protein is defective in forming a functional Magmas:DnaJC19 subcomplex and hence, the interaction of DnaJC19 with human TIM23 complex gets compromised.
[]
As a functional J or J-like domain is essential for the formation of a stable heterodimer, we predict that the truncated protein is defective in forming a functional Magmas:DnaJC19 subcomplex and hence, the interaction of DnaJC19 with human TIM23 complex gets compromised.
true
true
true
true
true
6,412
5
DISCUSSION
1
41
[ "DDQ002C41", "DDQ002C42", "DDQ002C47", "DDQ002C47", "DDQ002C47" ]
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
This leads to the deregulation of import motor activity causing improper protein import thereby, affecting mitochondria biogenesis and cellular respiration.
[ "41", "42", "47", "47", "47" ]
156
37,417
0
false
This leads to the deregulation of import motor activity causing improper protein import thereby, affecting mitochondria biogenesis and cellular respiration.
[]
This leads to the deregulation of import motor activity causing improper protein import thereby, affecting mitochondria biogenesis and cellular respiration.
true
true
true
true
true
6,412
5
DISCUSSION
1
41
[ "DDQ002C41", "DDQ002C42", "DDQ002C47", "DDQ002C47", "DDQ002C47" ]
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
The consequent impairment of energy metabolism in the cell especially in mitochondria-rich cardiac and neuronal tissues results in symptoms such as cardiomyopathy, peripheral neurodegeneration and ataxia.
[ "41", "42", "47", "47", "47" ]
204
37,418
0
false
The consequent impairment of energy metabolism in the cell especially in mitochondria-rich cardiac and neuronal tissues results in symptoms such as cardiomyopathy, peripheral neurodegeneration and ataxia.
[]
The consequent impairment of energy metabolism in the cell especially in mitochondria-rich cardiac and neuronal tissues results in symptoms such as cardiomyopathy, peripheral neurodegeneration and ataxia.
true
true
true
true
true
6,412
5
DISCUSSION
1
41
[ "DDQ002C41", "DDQ002C42", "DDQ002C47", "DDQ002C47", "DDQ002C47" ]
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
However, the relevance of upregulated Magmas levels other than protein import function is not well established, underlines the importance of future investigation.
[ "41", "42", "47", "47", "47" ]
162
37,419
0
false
However, the relevance of upregulated Magmas levels other than protein import function is not well established, underlines the importance of future investigation.
[]
However, the relevance of upregulated Magmas levels other than protein import function is not well established, underlines the importance of future investigation.
true
true
true
true
true
6,412
0
DISCUSSION
0
null
null
19,401,418
null
Our experiments show for the first time that SK4 channels participate in the regulation of β-cell function and glucose homeostasis in vivo.
null
139
37,420
0
false
null
null
Our experiments show for the first time that SK4 channels participate in the regulation of β-cell function and glucose homeostasis in vivo.
true
true
true
true
true
6,413
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
Glucose-induced insulin secretion involves tight coupling of glucose metabolism, electrical activity, [Ca2+]c, and exocytosis.
[ "46", "47", "33", "48", "34" ]
126
37,421
0
false
Glucose-induced insulin secretion involves tight coupling of glucose metabolism, electrical activity, [Ca2+]c, and exocytosis.
[]
Glucose-induced insulin secretion involves tight coupling of glucose metabolism, electrical activity, [Ca2+]c, and exocytosis.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
The key event linking glucose metabolism to membrane depolarization is the closure of KATP channels.
[ "46", "47", "33", "48", "34" ]
100
37,422
0
false
The key event linking glucose metabolism to membrane depolarization is the closure of KATP channels.
[]
The key event linking glucose metabolism to membrane depolarization is the closure of KATP channels.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
Subsequent opening of L-type Ca2+ channels increases [Ca2+]c, representing the triggering signal for insulin release (46,47).
[ "46", "47", "33", "48", "34" ]
125
37,423
0
false
Subsequent opening of L-type Ca2+ channels increases [Ca2+]c, representing the triggering signal for insulin release.
[ "46,47" ]
Subsequent opening of L-type Ca2+ channels increases [Ca2+]c, representing the triggering signal for insulin release.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
Our data show that SK4 channel protein is expressed in murine pancreatic islets.
[ "46", "47", "33", "48", "34" ]
80
37,424
0
false
Our data show that SK4 channel protein is expressed in murine pancreatic islets.
[]
Our data show that SK4 channel protein is expressed in murine pancreatic islets.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
SK4 channels are operative in β-cells and constitute an important regulator of stimulus-secretion coupling.
[ "46", "47", "33", "48", "34" ]
107
37,425
0
false
SK4 channels are operative in β-cells and constitute an important regulator of stimulus-secretion coupling.
[]
SK4 channels are operative in β-cells and constitute an important regulator of stimulus-secretion coupling.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
In WT β-cells, pharmacological opening or closure of SK4 channels crucially alters Vm (Figs.
[ "46", "47", "33", "48", "34" ]
92
37,426
0
false
In WT β-cells, pharmacological opening or closure of SK4 channels crucially alters Vm (Figs.
[]
In WT β-cells, pharmacological opening or closure of SK4 channels crucially alters Vm (Figs.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
Importantly, the SK4 channel blocker TRAM-34 depolarizes Vm and induces electrical activity at a subthreshold glucose concentration, thus enhancing the glucose effect on stimulus-secretion coupling (Fig.
[ "46", "47", "33", "48", "34" ]
203
37,427
0
false
Importantly, the SK4 channel blocker TRAM-34 depolarizes Vm and induces electrical activity at a subthreshold glucose concentration, thus enhancing the glucose effect on stimulus-secretion coupling (Fig.
[]
Importantly, the SK4 channel blocker TRAM-34 depolarizes Vm and induces electrical activity at a subthreshold glucose concentration, thus enhancing the glucose effect on stimulus-secretion coupling (Fig.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
This is of considerable significance, since it demonstrates that SK4 channels contribute to regulation of insulin release in the narrow range around the threshold blood glucose concentration physiologically relevant for glycemic control.
[ "46", "47", "33", "48", "34" ]
237
37,428
0
false
This is of considerable significance, since it demonstrates that SK4 channels contribute to regulation of insulin release in the narrow range around the threshold blood glucose concentration physiologically relevant for glycemic control.
[]
This is of considerable significance, since it demonstrates that SK4 channels contribute to regulation of insulin release in the narrow range around the threshold blood glucose concentration physiologically relevant for glycemic control.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
In addition, TRAM-34 and SK4-KO significantly reduce Kslow currents that are thought to participate in the characteristic burst pattern of pancreatic β-cells.
[ "46", "47", "33", "48", "34" ]
158
37,429
0
false
In addition, TRAM-34 and SK4-KO significantly reduce Kslow currents that are thought to participate in the characteristic burst pattern of pancreatic β-cells.
[]
In addition, TRAM-34 and SK4-KO significantly reduce Kslow currents that are thought to participate in the characteristic burst pattern of pancreatic β-cells.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
Our observation that SK4 is one component of Kslow (Fig.
[ "46", "47", "33", "48", "34" ]
56
37,430
0
false
Our observation that SK4 is one component of Kslow (Fig.
[]
Our observation that SK4 is one component of Kslow (Fig.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
2E) emphasizes the importance of the SK4 channel for β-cell electrical activity.
[ "46", "47", "33", "48", "34" ]
80
37,431
0
false
2E) emphasizes the importance of the SK4 channel for β-cell electrical activity.
[]
2E) emphasizes the importance of the SK4 channel for β-cell electrical activity.
false
false
true
true
false
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
Although the involvement of SK4 in Kslow generation is evidenced by the reduced current in SK4-KO β-cells and in TRAM-34–treated WT cells, charybdotoxin failed to affect Kslow.
[ "46", "47", "33", "48", "34" ]
176
37,432
0
false
Although the involvement of SK4 in Kslow generation is evidenced by the reduced current in SK4-KO β-cells and in TRAM-34–treated WT cells, charybdotoxin failed to affect Kslow.
[]
Although the involvement of SK4 in Kslow generation is evidenced by the reduced current in SK4-KO β-cells and in TRAM-34–treated WT cells, charybdotoxin failed to affect Kslow.
true
true
true
true
true
6,414
1
DISCUSSION
1
33
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
This observation requires further investigation but is in agreement with reports of others (33) describing inefficiency of the scorpion toxin on Kslow or on whole-cell currents with SK4 characteristics (48).
[ "46", "47", "33", "48", "34" ]
207
37,433
1
false
This observation requires further investigation but is in agreement with reports of others describing inefficiency of the scorpion toxin on Kslow or on whole-cell currents with SK4 characteristics.
[ "33", "48" ]
This observation requires further investigation but is in agreement with reports of others describing inefficiency of the scorpion toxin on Kslow or on whole-cell currents with SK4 characteristics.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
Importantly, the typical oscillations of glucose-stimulated β-cells are not prevented by SK4-KO, and Kslow is not completely absent in SK4-KO β-cells, even in the presence of 1 mmol/l tolbutamide.
[ "46", "47", "33", "48", "34" ]
196
37,434
0
false
Importantly, the typical oscillations of glucose-stimulated β-cells are not prevented by SK4-KO, and Kslow is not completely absent in SK4-KO β-cells, even in the presence of 1 mmol/l tolbutamide.
[]
Importantly, the typical oscillations of glucose-stimulated β-cells are not prevented by SK4-KO, and Kslow is not completely absent in SK4-KO β-cells, even in the presence of 1 mmol/l tolbutamide.
true
true
true
true
true
6,414
1
DISCUSSION
1
46
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
This suggests, in agreement with what has previously been proposed by Kanno et al.
[ "46", "47", "33", "48", "34" ]
82
37,435
0
false
This suggests, in agreement with what has previously been proposed by Kanno et al.
[]
This suggests, in agreement with what has previously been proposed by Kanno et al.
true
true
true
true
true
6,414
1
DISCUSSION
1
34
[ "B46", "B47", "B33", "B48", "B34" ]
19,401,418
pmid-2484976|pmid-8550572|pmid-10578013|pmid-9575286|pmid-12456829
(34), that KATP channels, SK4, and other KCa channels act in concert to regulate the bursting activity of pancreatic β-cells.
[ "46", "47", "33", "48", "34" ]
125
37,436
1
false
, that KATP channels, SK4, and other KCa channels act in concert to regulate the bursting activity of pancreatic β-cells.
[ "34" ]
, that KATP channels, SK4, and other KCa channels act in concert to regulate the bursting activity of pancreatic β-cells.
false
false
true
true
false
6,414
2
DISCUSSION
0
null
null
19,401,418
null
SK4-KO did not affect blood glucose concentration of fed or fasted mice, demonstrating that glucose homeostasis can be maintained by other factors, e.g., adaptation in central regulation of energy balance or activation of peripheral counterregulatory mechanisms.
null
262
37,437
0
false
null
null
SK4-KO did not affect blood glucose concentration of fed or fasted mice, demonstrating that glucose homeostasis can be maintained by other factors, e.g., adaptation in central regulation of energy balance or activation of peripheral counterregulatory mechanisms.
true
true
true
true
true
6,415
2
DISCUSSION
0
null
null
19,401,418
null
However, SK4-KO improved the glucose tolerance after glucose challenge, whereas insulin sensitivity remained unchanged (Fig.
null
124
37,438
0
false
null
null
However, SK4-KO improved the glucose tolerance after glucose challenge, whereas insulin sensitivity remained unchanged (Fig.
true
true
true
true
true
6,415
2
DISCUSSION
0
null
null
19,401,418
null
This strongly suggests that the β-cell is the major target of SK4-KO with regard to glycemic control.
null
101
37,439
0
false
null
null
This strongly suggests that the β-cell is the major target of SK4-KO with regard to glycemic control.
true
true
true
true
true
6,415
2
DISCUSSION
0
null
null
19,401,418
null
Indeed, SK4-KO β-cells displayed alterations in agreement with improved glucose tolerance: in glucose-stimulated SK4-KO β-cells, the plateau potential was more depolarized compared with WT cells.
null
195
37,440
0
false
null
null
Indeed, SK4-KO β-cells displayed alterations in agreement with improved glucose tolerance: in glucose-stimulated SK4-KO β-cells, the plateau potential was more depolarized compared with WT cells.
true
true
true
true
true
6,415
2
DISCUSSION
0
null
null
19,401,418
null
Consequently, the frequency of Ca2+ APs was increased by ∼30%.
null
62
37,441
0
false
null
null
Consequently, the frequency of Ca2+ APs was increased by ∼30%.
true
true
true
true
true
6,415
2
DISCUSSION
0
null
null
19,401,418
null
In addition, loss or blockade of SK4 channels resulted in AP broadening and elevated Ca2+ influx.
null
97
37,442
0
false
null
null
In addition, loss or blockade of SK4 channels resulted in AP broadening and elevated Ca2+ influx.
true
true
true
true
true
6,415
2
DISCUSSION
0
null
null
19,401,418
null
These effects are suited to enhance exocytosis and finally to improve glucose tolerance.
null
88
37,443
0
false
null
null
These effects are suited to enhance exocytosis and finally to improve glucose tolerance.
true
true
true
true
true
6,415
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
For control of insulin secretion, the concentration-response correlation of glucose and electrical activity is very important (49).
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
131
37,444
1
false
For control of insulin secretion, the concentration-response correlation of glucose and electrical activity is very important.
[ "49" ]
For control of insulin secretion, the concentration-response correlation of glucose and electrical activity is very important.
true
true
true
true
true
6,416
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
SK4-KO induced a clear left shift in glucose responsiveness with respect to Vm, [Ca2+]c, and insulin secretion (Fig.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
116
37,445
0
false
SK4-KO induced a clear left shift in glucose responsiveness with respect to Vm, c, and insulin secretion (Fig.
[ "Ca2+" ]
SK4-KO induced a clear left shift in glucose responsiveness with respect to Vm, c, and insulin secretion (Fig.
true
true
true
true
true
6,416
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
Furthermore, electrical activity could be induced by TRAM-34 applied to subthreshold glucose concentrations, i.e., when Vm is already depolarized but has not reached the threshold for Ca2+ APs (Fig.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
198
37,446
0
false
Furthermore, electrical activity could be induced by TRAM-34 applied to subthreshold glucose concentrations, i.e., when Vm is already depolarized but has not reached the threshold for Ca2+ APs (Fig.
[]
Furthermore, electrical activity could be induced by TRAM-34 applied to subthreshold glucose concentrations, i.e., when Vm is already depolarized but has not reached the threshold for Ca2+ APs (Fig.
true
true
true
true
true
6,416
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
It is well-known that the resting membrane potential of β-cells is predominantly carried by KATP current (50,51).
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
113
37,447
0
false
It is well-known that the resting membrane potential of β-cells is predominantly carried by KATP current.
[ "50,51" ]
It is well-known that the resting membrane potential of β-cells is predominantly carried by KATP current.
true
true
true
true
true
6,416
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
In agreement, SK4-KO did not affect the responsiveness of β-cells at low glucose concentrations (Fig.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
101
37,448
0
false
In agreement, SK4-KO did not affect the responsiveness of β-cells at low glucose concentrations (Fig.
[]
In agreement, SK4-KO did not affect the responsiveness of β-cells at low glucose concentrations (Fig.
true
true
true
true
true
6,416
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
3B) and TRAM-34 did not depolarize WT β-cells under resting conditions.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
71
37,449
0
false
3B) and TRAM-34 did not depolarize WT β-cells under resting conditions.
[]
3B) and TRAM-34 did not depolarize WT β-cells under resting conditions.
false
false
true
true
false
6,416
3
DISCUSSION
1
46
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
Regulation of insulin secretion occurs via a gradual decrease in the open probability of KATP channels in response to a stepwise elevation of glucose (46), thereby increasing membrane depolarization.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
199
37,450
1
false
Regulation of insulin secretion occurs via a gradual decrease in the open probability of KATP channels in response to a stepwise elevation of glucose, thereby increasing membrane depolarization.
[ "46" ]
Regulation of insulin secretion occurs via a gradual decrease in the open probability of KATP channels in response to a stepwise elevation of glucose, thereby increasing membrane depolarization.
true
true
true
true
true
6,416
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
SK4 channel opening is largely independent of Vm (2,52) but strictly regulated by [Ca2+]c.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
90
37,451
0
false
SK4 channel opening is largely independent of Vm but strictly regulated by c.
[ "2,52", "Ca2+" ]
SK4 channel opening is largely independent of Vm but strictly regulated by c.
true
true
true
true
true
6,416
3
DISCUSSION
1
53
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
Half-maximal activation occurs at Ca2+ concentrations ranging from 300 to 500 nmol/l (53).
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
90
37,452
1
false
Half-maximal activation occurs at Ca2+ concentrations ranging from 300 to 500 nmol/l.
[ "53" ]
Half-maximal activation occurs at Ca2+ concentrations ranging from 300 to 500 nmol/l.
true
true
true
true
true
6,416
3
DISCUSSION
1
52
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
For myocytes, it has been shown that SK4 channels are already open when Ca2+ is reduced below 100 nmol/l (52).
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
110
37,453
1
false
For myocytes, it has been shown that SK4 channels are already open when Ca2+ is reduced below 100 nmol/l.
[ "52" ]
For myocytes, it has been shown that SK4 channels are already open when Ca2+ is reduced below 100 nmol/l.
true
true
true
true
true
6,416
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
This is in agreement with our observation that SK4 channel inhibition influences Vm under conditions where [Ca2+]c is in the low nanomoles per liter range.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
155
37,454
0
false
This is in agreement with our observation that SK4 channel inhibition influences Vm under conditions where c is in the low nanomoles per liter range.
[ "Ca2+" ]
This is in agreement with our observation that SK4 channel inhibition influences Vm under conditions where c is in the low nanomoles per liter range.
true
true
true
true
true
6,416
3
DISCUSSION
1
54
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
For pancreatic β-cells, it was suggested that Ca2+ influx via L-type Ca2+ channels does not increase at a Vm below −40 mV (54).
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
127
37,455
1
false
For pancreatic β-cells, it was suggested that Ca2+ influx via L-type Ca2+ channels does not increase at a Vm below −40 mV.
[ "54" ]
For pancreatic β-cells, it was suggested that Ca2+ influx via L-type Ca2+ channels does not increase at a Vm below −40 mV.
true
true
true
true
true
6,416
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
This might raise the question why SK4 channel inhibition does not affect Vm at 0.5 mmol/l glucose but initiates APs at 6 mmol/l glucose.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
136
37,456
0
false
This might raise the question why SK4 channel inhibition does not affect Vm at 0.5 mmol/l glucose but initiates APs at 6 mmol/l glucose.
[]
This might raise the question why SK4 channel inhibition does not affect Vm at 0.5 mmol/l glucose but initiates APs at 6 mmol/l glucose.
true
true
true
true
true
6,416
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
However, because Larsson-Nyrén et al.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
37
37,457
0
false
However, because Larsson-Nyrén et al.
[]
However, because Larsson-Nyrén et al.
true
true
true
true
true
6,416
3
DISCUSSION
1
54
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
(54) induced Ca2+ influx by short depolarizing voltage steps starting at −70 mV, they cannot elucidate whether a gradual increase of Vm elevates Ca2+ channel activity, thereby promoting Ca2+ influx even below the threshold for Ca2+ APs.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
236
37,458
1
false
induced Ca2+ influx by short depolarizing voltage steps starting at −70 mV, they cannot elucidate whether a gradual increase of Vm elevates Ca2+ channel activity, thereby promoting Ca2+ influx even below the threshold for Ca2+ APs.
[ "54" ]
induced Ca2+ influx by short depolarizing voltage steps starting at −70 mV, they cannot elucidate whether a gradual increase of Vm elevates Ca2+ channel activity, thereby promoting Ca2+ influx even below the threshold for Ca2+ APs.
false
true
true
true
false
6,416
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
In this context, it is noteworthy that Nelson et al.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
52
37,459
0
false
In this context, it is noteworthy that Nelson et al.
[]
In this context, it is noteworthy that Nelson et al.
true
true
true
true
true
6,416
3
DISCUSSION
1
55
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
(55) demonstrated in cell-attached membrane patches of basilar arteries that the open probability of L-type Ca2+ channels already starts to increase at −65 mV, which is ∼20 mV more negative than the threshold potential for APs.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
227
37,460
1
false
demonstrated in cell-attached membrane patches of basilar arteries that the open probability of L-type Ca2+ channels already starts to increase at −65 mV, which is ∼20 mV more negative than the threshold potential for APs.
[ "55" ]
demonstrated in cell-attached membrane patches of basilar arteries that the open probability of L-type Ca2+ channels already starts to increase at −65 mV, which is ∼20 mV more negative than the threshold potential for APs.
false
true
true
true
false
6,416
3
DISCUSSION
1
49
[ "B49", "B50", "B51", "B46", "B2", "B52", "B53", "B52", "B54", "B54", "B55" ]
19,401,418
NA|NA|pmid-2407553|pmid-2484976|pmid-9730970|pmid-9630695|pmid-16443824|pmid-9630695|NA|NA|pmid-2164782
Consequently, glucose-regulated membrane depolarization might enhance SK4 channel activity dose dependently even before the threshold for induction of Ca2+ APs.
[ "49", "50", "51", "46", "2", "52", "53", "52", "54", "54", "55" ]
160
37,461
0
false
Consequently, glucose-regulated membrane depolarization might enhance SK4 channel activity dose dependently even before the threshold for induction of Ca2+ APs.
[]
Consequently, glucose-regulated membrane depolarization might enhance SK4 channel activity dose dependently even before the threshold for induction of Ca2+ APs.
true
true
true
true
true
6,416
4
DISCUSSION
1
5
[ "B5", "B56" ]
19,401,418
pmid-18523267|pmid-16873714
Our data suggest that membrane depolarization induced by closure of KATP channels leads to Ca2+ influx and subsequent activation of SK4 channels.
[ "5", "56" ]
145
37,462
0
false
Our data suggest that membrane depolarization induced by closure of KATP channels leads to Ca2+ influx and subsequent activation of SK4 channels.
[]
Our data suggest that membrane depolarization induced by closure of KATP channels leads to Ca2+ influx and subsequent activation of SK4 channels.
true
true
true
true
true
6,417
4
DISCUSSION
1
5
[ "B5", "B56" ]
19,401,418
pmid-18523267|pmid-16873714
This mechanism counteracts the depolarization and promotes closure of L-type Ca2+ channels.
[ "5", "56" ]
91
37,463
0
false
This mechanism counteracts the depolarization and promotes closure of L-type Ca2+ channels.
[]
This mechanism counteracts the depolarization and promotes closure of L-type Ca2+ channels.
true
true
true
true
true
6,417
4
DISCUSSION
1
5
[ "B5", "B56" ]
19,401,418
pmid-18523267|pmid-16873714
We hypothesize that modulation of β-cell activity via SK4 channels contributes to the precise adjustment of insulin secretion according to the current metabolic demands.
[ "5", "56" ]
169
37,464
0
false
We hypothesize that modulation of β-cell activity via SK4 channels contributes to the precise adjustment of insulin secretion according to the current metabolic demands.
[]
We hypothesize that modulation of β-cell activity via SK4 channels contributes to the precise adjustment of insulin secretion according to the current metabolic demands.
true
true
true
true
true
6,417
4
DISCUSSION
1
5
[ "B5", "B56" ]
19,401,418
pmid-18523267|pmid-16873714
An important regulatory function of SK4 channels concerning intracellular Ca2+ homeostasis has also been described for other cellular systems.
[ "5", "56" ]
142
37,465
0
false
An important regulatory function of SK4 channels concerning intracellular Ca2+ homeostasis has also been described for other cellular systems.
[]
An important regulatory function of SK4 channels concerning intracellular Ca2+ homeostasis has also been described for other cellular systems.
true
true
true
true
true
6,417
4
DISCUSSION
1
5
[ "B5", "B56" ]
19,401,418
pmid-18523267|pmid-16873714
In mast cells or in the endothelium, receptor-mediated Ca2+ influx activates SK4 channels, thereby inducing membrane hyperpolarization.
[ "5", "56" ]
135
37,466
0
false
In mast cells or in the endothelium, receptor-mediated Ca2+ influx activates SK4 channels, thereby inducing membrane hyperpolarization.
[]
In mast cells or in the endothelium, receptor-mediated Ca2+ influx activates SK4 channels, thereby inducing membrane hyperpolarization.
true
true
true
true
true
6,417
4
DISCUSSION
1
5
[ "B5", "B56" ]
19,401,418
pmid-18523267|pmid-16873714
However, in contrast to pancreatic β-cells, the increased K+ conductance enforces Ca2+ influx in these cells through transient receptor potential or store-operated Ca2+ channels.
[ "5", "56" ]
178
37,467
0
false
However, in contrast to pancreatic β-cells, the increased K+ conductance enforces Ca2+ influx in these cells through transient receptor potential or store-operated Ca2+ channels.
[]
However, in contrast to pancreatic β-cells, the increased K+ conductance enforces Ca2+ influx in these cells through transient receptor potential or store-operated Ca2+ channels.
true
true
true
true
true
6,417
4
DISCUSSION
1
5
[ "B5", "B56" ]
19,401,418
pmid-18523267|pmid-16873714
The final result is elevation of [Ca2+]c, which triggers mast cell degranulation or endothelium-mediated vasodilation, respectively (5,56).
[ "5", "56" ]
139
37,468
0
false
The final result is elevation of [Ca2+]c, which triggers mast cell degranulation or endothelium-mediated vasodilation, respectively.
[ "5,56" ]
The final result is elevation of [Ca2+]c, which triggers mast cell degranulation or endothelium-mediated vasodilation, respectively.
true
true
true
true
true
6,417
4
DISCUSSION
1
5
[ "B5", "B56" ]
19,401,418
pmid-18523267|pmid-16873714
Depending on the pathway of Ca2+ influx, SK4 channel activation could either enhance or limit Ca2+-regulated signaling cascades in different tissues or organs.
[ "5", "56" ]
159
37,469
0
false
Depending on the pathway of Ca2+ influx, SK4 channel activation could either enhance or limit Ca2+-regulated signaling cascades in different tissues or organs.
[]
Depending on the pathway of Ca2+ influx, SK4 channel activation could either enhance or limit Ca2+-regulated signaling cascades in different tissues or organs.
true
true
true
true
true
6,417
5
DISCUSSION
1
57
[ "B57", "B58" ]
19,401,418
pmid-9989540|pmid-15305887
As the Ca2+ dependence of SK4 channels is expected to couple channel activity to the metabolic status of pancreatic β-cells, SK4 channels may modulate cell function without bearing the risk for unwanted hypoglycemic episodes, which complicates the use of insulinotropic drugs acting on KATP channels (57,58).
[ "57", "58" ]
308
37,470
0
false
As the Ca2+ dependence of SK4 channels is expected to couple channel activity to the metabolic status of pancreatic β-cells, SK4 channels may modulate cell function without bearing the risk for unwanted hypoglycemic episodes, which complicates the use of insulinotropic drugs acting on KATP channels.
[ "57,58" ]
As the Ca2+ dependence of SK4 channels is expected to couple channel activity to the metabolic status of pancreatic β-cells, SK4 channels may modulate cell function without bearing the risk for unwanted hypoglycemic episodes, which complicates the use of insulinotropic drugs acting on KATP channels.
true
true
true
true
true
6,418
5
DISCUSSION
1
57
[ "B57", "B58" ]
19,401,418
pmid-9989540|pmid-15305887
Importantly, SK4-KO mice displayed no signs of hypoglycemia after overnight fasting or when they were fed ad libitum, which shows that the genetic manipulation did not result in excessive insulin secretion per se but improved β-cell response when challenged with high blood glucose concentrations.
[ "57", "58" ]
297
37,471
0
false
Importantly, SK4-KO mice displayed no signs of hypoglycemia after overnight fasting or when they were fed ad libitum, which shows that the genetic manipulation did not result in excessive insulin secretion per se but improved β-cell response when challenged with high blood glucose concentrations.
[]
Importantly, SK4-KO mice displayed no signs of hypoglycemia after overnight fasting or when they were fed ad libitum, which shows that the genetic manipulation did not result in excessive insulin secretion per se but improved β-cell response when challenged with high blood glucose concentrations.
true
true
true
true
true
6,418
5
DISCUSSION
1
57
[ "B57", "B58" ]
19,401,418
pmid-9989540|pmid-15305887
Because SK4-KO markedly elevated the proportion of active β-cells, it is suggested that a reduction of the SK4 current is a suitable tool to recruit more β-cells for nutrient-stimulated insulin release.
[ "57", "58" ]
202
37,472
0
false
Because SK4-KO markedly elevated the proportion of active β-cells, it is suggested that a reduction of the SK4 current is a suitable tool to recruit more β-cells for nutrient-stimulated insulin release.
[]
Because SK4-KO markedly elevated the proportion of active β-cells, it is suggested that a reduction of the SK4 current is a suitable tool to recruit more β-cells for nutrient-stimulated insulin release.
true
true
true
true
true
6,418
5
DISCUSSION
1
57
[ "B57", "B58" ]
19,401,418
pmid-9989540|pmid-15305887
Thus, targeting SK4 channels pharmacologically might be a useful approach to augment insulin release in β-cells with impaired secretory response.
[ "57", "58" ]
145
37,473
0
false
Thus, targeting SK4 channels pharmacologically might be a useful approach to augment insulin release in β-cells with impaired secretory response.
[]
Thus, targeting SK4 channels pharmacologically might be a useful approach to augment insulin release in β-cells with impaired secretory response.
true
true
true
true
true
6,418
0
INTRODUCTION
1
1
[ "B1", "B2", "B2", "B3", "B4" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
Long interspersed element-1, LINE-1 or L1, is an autonomous family of retroelements that is currently active in mammalian genomes (1).
[ "1", "2", "2", "3", "4" ]
134
37,474
1
false
Long interspersed element-1, LINE-1 or L1, is an autonomous family of retroelements that is currently active in mammalian genomes.
[ "1" ]
Long interspersed element-1, LINE-1 or L1, is an autonomous family of retroelements that is currently active in mammalian genomes.
true
true
true
true
true
6,419
0
INTRODUCTION
1
2
[ "B1", "B2", "B2", "B3", "B4" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
The human genome has accumulated about 500 000 L1 copies, amounting to 17% of genomic content (2).
[ "1", "2", "2", "3", "4" ]
98
37,475
1
false
The human genome has accumulated about 500 000 L1 copies, amounting to 17% of genomic content.
[ "2" ]
The human genome has accumulated about 500 000 L1 copies, amounting to 17% of genomic content.
true
true
true
true
true
6,419
0
INTRODUCTION
1
2
[ "B1", "B2", "B2", "B3", "B4" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
The majority of L1 inserts are 5′-truncated or rearranged (2); and as a result they are retrotranspositionally inactive.
[ "1", "2", "2", "3", "4" ]
120
37,476
1
false
The majority of L1 inserts are 5′-truncated or rearranged ; and as a result they are retrotranspositionally inactive.
[ "2" ]
The majority of L1 inserts are 5′-truncated or rearranged ; and as a result they are retrotranspositionally inactive.
true
true
true
true
true
6,419
0
INTRODUCTION
1
1
[ "B1", "B2", "B2", "B3", "B4" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
Approximately 3000 L1s in the human genome are full-length (i.e.
[ "1", "2", "2", "3", "4" ]
64
37,477
0
false
Approximately 3000 L1s in the human genome are full-length (i.e.
[]
Approximately 3000 L1s in the human genome are full-length (i.e.
true
true
true
true
true
6,419
0
INTRODUCTION
1
3
[ "B1", "B2", "B2", "B3", "B4" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
they contain 5′- and 3′-UTRs and sequences in between without major rearrangement), with about 150 containing both intact open reading frames (ORF) 1 and 2, and about 100 additional elements maintaining only intact ORF2 (3).
[ "1", "2", "2", "3", "4" ]
224
37,478
1
false
they contain 5′- and 3′-UTRs and sequences in between without major rearrangement), with about 150 containing both intact open reading frames (ORF) 1 and 2, and about 100 additional elements maintaining only intact ORF2.
[ "3" ]
they contain 5′- and 3′-UTRs and sequences in between without major rearrangement), with about 150 containing both intact open reading frames (ORF) 1 and 2, and about 100 additional elements maintaining only intact ORF2.
false
true
true
true
false
6,419
0
INTRODUCTION
1
4
[ "B1", "B2", "B2", "B3", "B4" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
Both ORFs are required for L1 retrotransposition in cultured cells (4).
[ "1", "2", "2", "3", "4" ]
71
37,479
1
false
Both ORFs are required for L1 retrotransposition in cultured cells.
[ "4" ]
Both ORFs are required for L1 retrotransposition in cultured cells.
true
true
true
true
true
6,419
1
INTRODUCTION
1
5–7
[ "B5 B6 B7", "B8", "B9", "B10", "B7", "B11", "B12", "B13", "B14", "B15", "B16", "B17", "B18", "B11", "B19 B20 B21" ]
20,215,437
pmid-8139560|pmid-7878012|pmid-15056671|pmid-12415270|pmid-17145770|pmid-2454389|pmid-15056671|pmid-15959507|pmid-19772661|pmid-19657334|pmid-16554555|pmid-14625551|pmid-1310068|pmid-16698926|pmid-17145770|pmid-15959507|pmid-17124176|pmid-16365384|pmid-18615728|pmid-12897783|pmid-14628287|pmid-10742098|pmid-12897783
L1 expression in the germ line and cells that are closely associated with the germ line has been previously reported (5–7).
[ "5–7", "8", "9", "10", "7", "11", "12", "13", "14", "15", "16", "17", "18", "11", "19–21" ]
123
37,480
1
false
L1 expression in the germ line and cells that are closely associated with the germ line has been previously reported.
[ "5–7" ]
L1 expression in the germ line and cells that are closely associated with the germ line has been previously reported.
true
true
true
true
true
6,420
1
INTRODUCTION
1
10
[ "B5 B6 B7", "B8", "B9", "B10", "B7", "B11", "B12", "B13", "B14", "B15", "B16", "B17", "B18", "B11", "B19 B20 B21" ]
20,215,437
pmid-8139560|pmid-7878012|pmid-15056671|pmid-12415270|pmid-17145770|pmid-2454389|pmid-15056671|pmid-15959507|pmid-19772661|pmid-19657334|pmid-16554555|pmid-14625551|pmid-1310068|pmid-16698926|pmid-17145770|pmid-15959507|pmid-17124176|pmid-16365384|pmid-18615728|pmid-12897783|pmid-14628287|pmid-10742098|pmid-12897783
It has been suggested that full-length L1 mRNA is expressed little, if at all, in somatic tissues (8,9), although it has generally been detected in somatic cells that underwent malignant transformation (10).
[ "5–7", "8", "9", "10", "7", "11", "12", "13", "14", "15", "16", "17", "18", "11", "19–21" ]
207
37,481
1
false
It has been suggested that full-length L1 mRNA is expressed little, if at all, in somatic tissues, although it has generally been detected in somatic cells that underwent malignant transformation.
[ "8,9", "10" ]
It has been suggested that full-length L1 mRNA is expressed little, if at all, in somatic tissues, although it has generally been detected in somatic cells that underwent malignant transformation.
true
true
true
true
true
6,420
1
INTRODUCTION
1
5–7
[ "B5 B6 B7", "B8", "B9", "B10", "B7", "B11", "B12", "B13", "B14", "B15", "B16", "B17", "B18", "B11", "B19 B20 B21" ]
20,215,437
pmid-8139560|pmid-7878012|pmid-15056671|pmid-12415270|pmid-17145770|pmid-2454389|pmid-15056671|pmid-15959507|pmid-19772661|pmid-19657334|pmid-16554555|pmid-14625551|pmid-1310068|pmid-16698926|pmid-17145770|pmid-15959507|pmid-17124176|pmid-16365384|pmid-18615728|pmid-12897783|pmid-14628287|pmid-10742098|pmid-12897783
Recent reports have shown, in addition to the germ line, some L1 protein expression in vascular endothelial cells of human male gonads, L1 RNA expression in lymphoblastoid cell lines, and L1 mobilization in the brains of L1-transgenic mice (7,11,12).
[ "5–7", "8", "9", "10", "7", "11", "12", "13", "14", "15", "16", "17", "18", "11", "19–21" ]
250
37,482
0
false
Recent reports have shown, in addition to the germ line, some L1 protein expression in vascular endothelial cells of human male gonads, L1 RNA expression in lymphoblastoid cell lines, and L1 mobilization in the brains of L1-transgenic mice.
[ "7,11,12" ]
Recent reports have shown, in addition to the germ line, some L1 protein expression in vascular endothelial cells of human male gonads, L1 RNA expression in lymphoblastoid cell lines, and L1 mobilization in the brains of L1-transgenic mice.
true
true
true
true
true
6,420
1
INTRODUCTION
1
13
[ "B5 B6 B7", "B8", "B9", "B10", "B7", "B11", "B12", "B13", "B14", "B15", "B16", "B17", "B18", "B11", "B19 B20 B21" ]
20,215,437
pmid-8139560|pmid-7878012|pmid-15056671|pmid-12415270|pmid-17145770|pmid-2454389|pmid-15056671|pmid-15959507|pmid-19772661|pmid-19657334|pmid-16554555|pmid-14625551|pmid-1310068|pmid-16698926|pmid-17145770|pmid-15959507|pmid-17124176|pmid-16365384|pmid-18615728|pmid-12897783|pmid-14628287|pmid-10742098|pmid-12897783
Unmethylated L1 loci and L1 mobilization has been reported in normal human brain (13).
[ "5–7", "8", "9", "10", "7", "11", "12", "13", "14", "15", "16", "17", "18", "11", "19–21" ]
86
37,483
1
false
Unmethylated L1 loci and L1 mobilization has been reported in normal human brain.
[ "13" ]
Unmethylated L1 loci and L1 mobilization has been reported in normal human brain.
true
true
true
true
true
6,420
1
INTRODUCTION
1
5–7
[ "B5 B6 B7", "B8", "B9", "B10", "B7", "B11", "B12", "B13", "B14", "B15", "B16", "B17", "B18", "B11", "B19 B20 B21" ]
20,215,437
pmid-8139560|pmid-7878012|pmid-15056671|pmid-12415270|pmid-17145770|pmid-2454389|pmid-15056671|pmid-15959507|pmid-19772661|pmid-19657334|pmid-16554555|pmid-14625551|pmid-1310068|pmid-16698926|pmid-17145770|pmid-15959507|pmid-17124176|pmid-16365384|pmid-18615728|pmid-12897783|pmid-14628287|pmid-10742098|pmid-12897783
Because the vast majority of the L1 RNA is spliced and/or prematurely polyadenylated (14,15), detection of L1 proteins in a cell is not a reliable indicator of the retrotransposition potential.
[ "5–7", "8", "9", "10", "7", "11", "12", "13", "14", "15", "16", "17", "18", "11", "19–21" ]
193
37,484
0
false
Because the vast majority of the L1 RNA is spliced and/or prematurely polyadenylated, detection of L1 proteins in a cell is not a reliable indicator of the retrotransposition potential.
[ "14,15" ]
Because the vast majority of the L1 RNA is spliced and/or prematurely polyadenylated, detection of L1 proteins in a cell is not a reliable indicator of the retrotransposition potential.
true
true
true
true
true
6,420
1
INTRODUCTION
1
16
[ "B5 B6 B7", "B8", "B9", "B10", "B7", "B11", "B12", "B13", "B14", "B15", "B16", "B17", "B18", "B11", "B19 B20 B21" ]
20,215,437
pmid-8139560|pmid-7878012|pmid-15056671|pmid-12415270|pmid-17145770|pmid-2454389|pmid-15056671|pmid-15959507|pmid-19772661|pmid-19657334|pmid-16554555|pmid-14625551|pmid-1310068|pmid-16698926|pmid-17145770|pmid-15959507|pmid-17124176|pmid-16365384|pmid-18615728|pmid-12897783|pmid-14628287|pmid-10742098|pmid-12897783
Endogenous L1 elements (16), L1 elements transiently expressed in primary cells (17,18), and in somatic cells of transgenic mice (11,19–21), are capable of retrotransposition indicating that there are no intrinsic molecular limitations for L1 protein activity specific to somatic cells.
[ "5–7", "8", "9", "10", "7", "11", "12", "13", "14", "15", "16", "17", "18", "11", "19–21" ]
286
37,485
1
false
Endogenous L1 elements, L1 elements transiently expressed in primary cells, and in somatic cells of transgenic mice, are capable of retrotransposition indicating that there are no intrinsic molecular limitations for L1 protein activity specific to somatic cells.
[ "16", "17,18", "11,19–21" ]
Endogenous L1 elements, L1 elements transiently expressed in primary cells, and in somatic cells of transgenic mice, are capable of retrotransposition indicating that there are no intrinsic molecular limitations for L1 protein activity specific to somatic cells.
true
true
true
true
true
6,420
2
INTRODUCTION
1
4
[ "B4", "B22", "B23", "B24" ]
20,215,437
pmid-8945518|pmid-12897783|pmid-18256243|pmid-15983781|pmid-18256243|pmid-11237011|pmid-11237011|pmid-14638329
There are a broad range of factors that lead to DNA damage, both in the germ line and somatic cells.
[ "4", "22", "23", "24" ]
100
37,486
0
false
There are a broad range of factors that lead to DNA damage, both in the germ line and somatic cells.
[]
There are a broad range of factors that lead to DNA damage, both in the germ line and somatic cells.
true
true
true
true
true
6,421
2
INTRODUCTION
1
4
[ "B4", "B22", "B23", "B24" ]
20,215,437
pmid-8945518|pmid-12897783|pmid-18256243|pmid-15983781|pmid-18256243|pmid-11237011|pmid-11237011|pmid-14638329
There has been a significant focus on exogenous (i.e.
[ "4", "22", "23", "24" ]
53
37,487
0
false
There has been a significant focus on exogenous (i.e.
[]
There has been a significant focus on exogenous (i.e.
true
true
true
true
true
6,421
2
INTRODUCTION
1
4
[ "B4", "B22", "B23", "B24" ]
20,215,437
pmid-8945518|pmid-12897783|pmid-18256243|pmid-15983781|pmid-18256243|pmid-11237011|pmid-11237011|pmid-14638329
radiation and chemicals), as well as endogenous [replication errors and reactive oxygen species (ROS)], sources of somatic DNA damage.
[ "4", "22", "23", "24" ]
134
37,488
0
false
radiation and chemicals), as well as endogenous [replication errors and reactive oxygen species (ROS)], sources of somatic DNA damage.
[]
radiation and chemicals), as well as endogenous [replication errors and reactive oxygen species (ROS)], sources of somatic DNA damage.
false
true
true
true
false
6,421
2
INTRODUCTION
1
4
[ "B4", "B22", "B23", "B24" ]
20,215,437
pmid-8945518|pmid-12897783|pmid-18256243|pmid-15983781|pmid-18256243|pmid-11237011|pmid-11237011|pmid-14638329
As demonstrated by the disease causing in vivo integration events and tissue culture experiments, expression of the functional L1 elements in human cells results in integration events of L1 as well as its parasites, short interspersed elements (SINEs) and presumably SVA elements.
[ "4", "22", "23", "24" ]
280
37,489
0
false
As demonstrated by the disease causing in vivo integration events and tissue culture experiments, expression of the functional L1 elements in human cells results in integration events of L1 as well as its parasites, short interspersed elements (SINEs) and presumably SVA elements.
[]
As demonstrated by the disease causing in vivo integration events and tissue culture experiments, expression of the functional L1 elements in human cells results in integration events of L1 as well as its parasites, short interspersed elements (SINEs) and presumably SVA elements.
true
true
true
true
true
6,421
2
INTRODUCTION
1
4
[ "B4", "B22", "B23", "B24" ]
20,215,437
pmid-8945518|pmid-12897783|pmid-18256243|pmid-15983781|pmid-18256243|pmid-11237011|pmid-11237011|pmid-14638329
While retrotransposition of L1 elements requires production of the full-length L1 mRNA that contains both functional ORF1 and ORF2 proteins (4), SINE retrotransposons (such as Alu elements) rely only on the production of the functional L1 ORF2 protein in tissue culture-based assays (22).
[ "4", "22", "23", "24" ]
288
37,490
1
false
While retrotransposition of L1 elements requires production of the full-length L1 mRNA that contains both functional ORF1 and ORF2 proteins, SINE retrotransposons (such as Alu elements) rely only on the production of the functional L1 ORF2 protein in tissue culture-based assays.
[ "4", "22" ]
While retrotransposition of L1 elements requires production of the full-length L1 mRNA that contains both functional ORF1 and ORF2 proteins, SINE retrotransposons (such as Alu elements) rely only on the production of the functional L1 ORF2 protein in tissue culture-based assays.
true
true
true
true
true
6,421
2
INTRODUCTION
1
4
[ "B4", "B22", "B23", "B24" ]
20,215,437
pmid-8945518|pmid-12897783|pmid-18256243|pmid-15983781|pmid-18256243|pmid-11237011|pmid-11237011|pmid-14638329
Alu retrotransposons have been much more successful than L1 in occupying the human genome (accumulating to over 1 000 000 copies) and causing over twice the number of diseases originated by L1 elements (23,24).
[ "4", "22", "23", "24" ]
210
37,491
0
false
Alu retrotransposons have been much more successful than L1 in occupying the human genome (accumulating to over 1 000 000 copies) and causing over twice the number of diseases originated by L1 elements.
[ "23,24" ]
Alu retrotransposons have been much more successful than L1 in occupying the human genome (accumulating to over 1 000 000 copies) and causing over twice the number of diseases originated by L1 elements.
true
true
true
true
true
6,421
2
INTRODUCTION
1
4
[ "B4", "B22", "B23", "B24" ]
20,215,437
pmid-8945518|pmid-12897783|pmid-18256243|pmid-15983781|pmid-18256243|pmid-11237011|pmid-11237011|pmid-14638329
This difference in the total genomic copy number of L1 and Alu elements may come from the variation in the retrotransposition efficiency, post-insertional selection, or both.
[ "4", "22", "23", "24" ]
174
37,492
0
false
This difference in the total genomic copy number of L1 and Alu elements may come from the variation in the retrotransposition efficiency, post-insertional selection, or both.
[]
This difference in the total genomic copy number of L1 and Alu elements may come from the variation in the retrotransposition efficiency, post-insertional selection, or both.
true
true
true
true
true
6,421
3
INTRODUCTION
1
25–27
[ "B25 B26 B27", "B27", "B28", "B27", "B25", "B29" ]
20,215,437
pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-11684443|pmid-16490214|pmid-16670018|pmid-18555620|pmid-1701022|pmid-7693554|pmid-18396111|pmid-16936727|pmid-16728505|pmid-16735504|pmid-16648136
In addition to insertional mutagenesis, expression of the functional wild-type (wt) full-length L1, or L1 ORF2 protein alone, in human cancer cells induces DNA double-strand breaks (DSBs) (25–27) in great excess relative to the integration events detected under the same conditions (27).
[ "25–27", "27", "28", "27", "25", "29" ]
287
37,493
1
false
In addition to insertional mutagenesis, expression of the functional wild-type (wt) full-length L1, or L1 ORF2 protein alone, in human cancer cells induces DNA double-strand breaks (DSBs) in great excess relative to the integration events detected under the same conditions.
[ "25–27", "27" ]
In addition to insertional mutagenesis, expression of the functional wild-type (wt) full-length L1, or L1 ORF2 protein alone, in human cancer cells induces DNA double-strand breaks (DSBs) in great excess relative to the integration events detected under the same conditions.
true
true
true
true
true
6,422
3
INTRODUCTION
1
25–27
[ "B25 B26 B27", "B27", "B28", "B27", "B25", "B29" ]
20,215,437
pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-11684443|pmid-16490214|pmid-16670018|pmid-18555620|pmid-1701022|pmid-7693554|pmid-18396111|pmid-16936727|pmid-16728505|pmid-16735504|pmid-16648136
DNA DSBs are known to be highly toxic and mutagenic even when repaired by the wt DNA repair machinery in mammals [reviewed in ref.
[ "25–27", "27", "28", "27", "25", "29" ]
130
37,494
0
false
DNA DSBs are known to be highly toxic and mutagenic even when repaired by the wt DNA repair machinery in mammals [reviewed in ref.
[]
DNA DSBs are known to be highly toxic and mutagenic even when repaired by the wt DNA repair machinery in mammals [reviewed in ref.
true
true
true
true
true
6,422
3
INTRODUCTION
1
25–27
[ "B25 B26 B27", "B27", "B28", "B27", "B25", "B29" ]
20,215,437
pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-11684443|pmid-16490214|pmid-16670018|pmid-18555620|pmid-1701022|pmid-7693554|pmid-18396111|pmid-16936727|pmid-16728505|pmid-16735504|pmid-16648136
The cellular response to DNA damage usually manifests itself in cell cycle arrest, cell death (apoptosis or necrosis), or senescence.
[ "25–27", "27", "28", "27", "25", "29" ]
133
37,495
0
false
The cellular response to DNA damage usually manifests itself in cell cycle arrest, cell death (apoptosis or necrosis), or senescence.
[]
The cellular response to DNA damage usually manifests itself in cell cycle arrest, cell death (apoptosis or necrosis), or senescence.
true
true
true
true
true
6,422
3
INTRODUCTION
1
27
[ "B25 B26 B27", "B27", "B28", "B27", "B25", "B29" ]
20,215,437
pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-11684443|pmid-16490214|pmid-16670018|pmid-18555620|pmid-1701022|pmid-7693554|pmid-18396111|pmid-16936727|pmid-16728505|pmid-16735504|pmid-16648136
L1 expression in human cancer cells has been reported to induce cell cycle arrest (27) and apoptosis (25,29).
[ "25–27", "27", "28", "27", "25", "29" ]
109
37,496
1
false
L1 expression in human cancer cells has been reported to induce cell cycle arrest and apoptosis.
[ "27", "25,29" ]
L1 expression in human cancer cells has been reported to induce cell cycle arrest and apoptosis.
true
true
true
true
true
6,422
4
INTRODUCTION
1
14
[ "B14", "B15", "B30", "B23" ]
20,215,437
pmid-16554555|pmid-14625551|pmid-18261861|pmid-18256243|pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-16554555|pmid-18381897|pmid-17028956|pmid-17157332|pmid-16490214|pmid-8945517|pmid-12897783|pmid-16670018|pmid-15888314|pmid-17202845|pmid-1952798|pmid-3453778
Because L1 expression can contribute to DNA damage not only through insertional mutagenesis but also via generation of DSBs, a better understanding of the expression patterns of endogenous L1 elements, particularly because of the complex processing of their mRNA (14,15,30), would provide a more complete picture of the ...
[ "14", "15", "30", "23" ]
357
37,497
0
false
Because L1 expression can contribute to DNA damage not only through insertional mutagenesis but also via generation of DSBs, a better understanding of the expression patterns of endogenous L1 elements, particularly because of the complex processing of their mRNA, would provide a more complete picture of the potential s...
[ "14,15,30" ]
Because L1 expression can contribute to DNA damage not only through insertional mutagenesis but also via generation of DSBs, a better understanding of the expression patterns of endogenous L1 elements, particularly because of the complex processing of their mRNA, would provide a more complete picture of the potential s...
true
true
true
true
true
6,423
4
INTRODUCTION
1
14
[ "B14", "B15", "B30", "B23" ]
20,215,437
pmid-16554555|pmid-14625551|pmid-18261861|pmid-18256243|pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-16554555|pmid-18381897|pmid-17028956|pmid-17157332|pmid-16490214|pmid-8945517|pmid-12897783|pmid-16670018|pmid-15888314|pmid-17202845|pmid-1952798|pmid-3453778
Our data demonstrate ongoing L1 expression in a broad spectrum of normal human tissues including adult stem cells.
[ "14", "15", "30", "23" ]
114
37,498
0
false
Our data demonstrate ongoing L1 expression in a broad spectrum of normal human tissues including adult stem cells.
[]
Our data demonstrate ongoing L1 expression in a broad spectrum of normal human tissues including adult stem cells.
true
true
true
true
true
6,423
4
INTRODUCTION
1
14
[ "B14", "B15", "B30", "B23" ]
20,215,437
pmid-16554555|pmid-14625551|pmid-18261861|pmid-18256243|pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-16554555|pmid-18381897|pmid-17028956|pmid-17157332|pmid-16490214|pmid-8945517|pmid-12897783|pmid-16670018|pmid-15888314|pmid-17202845|pmid-1952798|pmid-3453778
Both the expression levels and the L1 RNA processing vary dramatically among the tissues tested in this study.
[ "14", "15", "30", "23" ]
110
37,499
0
false
Both the expression levels and the L1 RNA processing vary dramatically among the tissues tested in this study.
[]
Both the expression levels and the L1 RNA processing vary dramatically among the tissues tested in this study.
true
true
true
true
true
6,423
4
INTRODUCTION
1
14
[ "B14", "B15", "B30", "B23" ]
20,215,437
pmid-16554555|pmid-14625551|pmid-18261861|pmid-18256243|pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-16554555|pmid-18381897|pmid-17028956|pmid-17157332|pmid-16490214|pmid-8945517|pmid-12897783|pmid-16670018|pmid-15888314|pmid-17202845|pmid-1952798|pmid-3453778
We provide experimental support that L1-related DNA damage in human somatic cells is not limited to the production of the full-length L1 mRNA because of the expression of the L1 splice transcript that likely contributes to the translation of the L1 ORF2 protein.
[ "14", "15", "30", "23" ]
262
37,500
0
false
We provide experimental support that L1-related DNA damage in human somatic cells is not limited to the production of the full-length L1 mRNA because of the expression of the L1 splice transcript that likely contributes to the translation of the L1 ORF2 protein.
[]
We provide experimental support that L1-related DNA damage in human somatic cells is not limited to the production of the full-length L1 mRNA because of the expression of the L1 splice transcript that likely contributes to the translation of the L1 ORF2 protein.
true
true
true
true
true
6,423
4
INTRODUCTION
1
14
[ "B14", "B15", "B30", "B23" ]
20,215,437
pmid-16554555|pmid-14625551|pmid-18261861|pmid-18256243|pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-16554555|pmid-18381897|pmid-17028956|pmid-17157332|pmid-16490214|pmid-8945517|pmid-12897783|pmid-16670018|pmid-15888314|pmid-17202845|pmid-1952798|pmid-3453778
The SpORF2 transcript is detected in numerous human tissues and the expression of SpORF2 mRNA exhibits tissues-specific variation.
[ "14", "15", "30", "23" ]
130
37,501
0
false
The SpORF2 transcript is detected in numerous human tissues and the expression of SpORF2 mRNA exhibits tissues-specific variation.
[]
The SpORF2 transcript is detected in numerous human tissues and the expression of SpORF2 mRNA exhibits tissues-specific variation.
true
true
true
true
true
6,423
4
INTRODUCTION
1
14
[ "B14", "B15", "B30", "B23" ]
20,215,437
pmid-16554555|pmid-14625551|pmid-18261861|pmid-18256243|pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-16554555|pmid-18381897|pmid-17028956|pmid-17157332|pmid-16490214|pmid-8945517|pmid-12897783|pmid-16670018|pmid-15888314|pmid-17202845|pmid-1952798|pmid-3453778
We also demonstrate that transient expression of the wt L1 or the splice SpORF2 product in normal human fibroblasts and adult stem cells leads to a senescence-like phenotype.
[ "14", "15", "30", "23" ]
174
37,502
0
false
We also demonstrate that transient expression of the wt L1 or the splice SpORF2 product in normal human fibroblasts and adult stem cells leads to a senescence-like phenotype.
[]
We also demonstrate that transient expression of the wt L1 or the splice SpORF2 product in normal human fibroblasts and adult stem cells leads to a senescence-like phenotype.
true
true
true
true
true
6,423
4
INTRODUCTION
1
14
[ "B14", "B15", "B30", "B23" ]
20,215,437
pmid-16554555|pmid-14625551|pmid-18261861|pmid-18256243|pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-16554555|pmid-18381897|pmid-17028956|pmid-17157332|pmid-16490214|pmid-8945517|pmid-12897783|pmid-16670018|pmid-15888314|pmid-17202845|pmid-1952798|pmid-3453778
Because L1 activity has been well established to contribute to germ line mutagenesis
[ "14", "15", "30", "23" ]
84
37,503
0
false
Because L1 activity has been well established to contribute to germ line mutagenesis
[]
Because L1 activity has been well established to contribute to germ line mutagenesis
true
true
false
true
false
6,423
4
INTRODUCTION
1
14
[ "B14", "B15", "B30", "B23" ]
20,215,437
pmid-16554555|pmid-14625551|pmid-18261861|pmid-18256243|pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-16554555|pmid-18381897|pmid-17028956|pmid-17157332|pmid-16490214|pmid-8945517|pmid-12897783|pmid-16670018|pmid-15888314|pmid-17202845|pmid-1952798|pmid-3453778
[reviewed in ref.
[ "14", "15", "30", "23" ]
17
37,504
0
false
[reviewed in ref.
[]
[reviewed in ref.
false
false
true
true
false
6,423
4
INTRODUCTION
1
23
[ "B14", "B15", "B30", "B23" ]
20,215,437
pmid-16554555|pmid-14625551|pmid-18261861|pmid-18256243|pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-16554555|pmid-18381897|pmid-17028956|pmid-17157332|pmid-16490214|pmid-8945517|pmid-12897783|pmid-16670018|pmid-15888314|pmid-17202845|pmid-1952798|pmid-3453778
(23)], our finding of somatic L1 expression in a number of human tissues suggests that L1 elements need to be considered as an endogenous mutagen not only in germ line but also in somatic tissues for humans.
[ "14", "15", "30", "23" ]
207
37,505
1
false
], our finding of somatic L1 expression in a number of human tissues suggests that L1 elements need to be considered as an endogenous mutagen not only in germ line but also in somatic tissues for humans.
[ "23" ]
], our finding of somatic L1 expression in a number of human tissues suggests that L1 elements need to be considered as an endogenous mutagen not only in germ line but also in somatic tissues for humans.
false
false
true
true
false
6,423
4
INTRODUCTION
1
14
[ "B14", "B15", "B30", "B23" ]
20,215,437
pmid-16554555|pmid-14625551|pmid-18261861|pmid-18256243|pmid-16670018|pmid-16507671|pmid-16490214|pmid-16490214|pmid-16554555|pmid-18381897|pmid-17028956|pmid-17157332|pmid-16490214|pmid-8945517|pmid-12897783|pmid-16670018|pmid-15888314|pmid-17202845|pmid-1952798|pmid-3453778
Our findings suggest that even low levels of somatic DNA damage due to L1 activity have the potential to contribute to genetic instability, aging, and age-related diseases, such as cancer.
[ "14", "15", "30", "23" ]
188
37,506
0
false
Our findings suggest that even low levels of somatic DNA damage due to L1 activity have the potential to contribute to genetic instability, aging, and age-related diseases, such as cancer.
[]
Our findings suggest that even low levels of somatic DNA damage due to L1 activity have the potential to contribute to genetic instability, aging, and age-related diseases, such as cancer.
true
true
true
true
true
6,423
0
DISCUSSION
1
5
[ "B5", "B6", "B8", "B21", "B37", "B38" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
The field of human mobile elements has often focused on their mutagenic effect within the germ line (5,6) because transposable element amplification to high copy number in the genome is dependent on germ line insertions.
[ "5", "6", "8", "21", "37", "38" ]
220
37,507
0
false
The field of human mobile elements has often focused on their mutagenic effect within the germ line because transposable element amplification to high copy number in the genome is dependent on germ line insertions.
[ "5,6" ]
The field of human mobile elements has often focused on their mutagenic effect within the germ line because transposable element amplification to high copy number in the genome is dependent on germ line insertions.
true
true
true
true
true
6,424
0
DISCUSSION
1
5
[ "B5", "B6", "B8", "B21", "B37", "B38" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
Detection of endogenous FL or SpORF2 L1 transcripts in this study in many tested adult tissues broadens the potential impact of mobile elements on human health and development.
[ "5", "6", "8", "21", "37", "38" ]
176
37,508
0
false
Detection of endogenous FL or SpORF2 L1 transcripts in this study in many tested adult tissues broadens the potential impact of mobile elements on human health and development.
[]
Detection of endogenous FL or SpORF2 L1 transcripts in this study in many tested adult tissues broadens the potential impact of mobile elements on human health and development.
true
true
true
true
true
6,424
0
DISCUSSION
1
8
[ "B5", "B6", "B8", "B21", "B37", "B38" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
Our findings of modest levels of the FL L1 expression in human ovary and testis, and expression of only processed L1 mRNAs in kidney, lung, liver and brain are in agreement with the reported expression in a transgenic mouse model (8).
[ "5", "6", "8", "21", "37", "38" ]
234
37,509
1
false
Our findings of modest levels of the FL L1 expression in human ovary and testis, and expression of only processed L1 mRNAs in kidney, lung, liver and brain are in agreement with the reported expression in a transgenic mouse model.
[ "8" ]
Our findings of modest levels of the FL L1 expression in human ovary and testis, and expression of only processed L1 mRNAs in kidney, lung, liver and brain are in agreement with the reported expression in a transgenic mouse model.
true
true
true
true
true
6,424
0
DISCUSSION
1
5
[ "B5", "B6", "B8", "B21", "B37", "B38" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
However, sporadic tissues, such as esophagus, placenta and prostate demonstrate that some somatic tissues can express L1 elements fairly well.
[ "5", "6", "8", "21", "37", "38" ]
142
37,510
0
false
However, sporadic tissues, such as esophagus, placenta and prostate demonstrate that some somatic tissues can express L1 elements fairly well.
[]
However, sporadic tissues, such as esophagus, placenta and prostate demonstrate that some somatic tissues can express L1 elements fairly well.
true
true
true
true
true
6,424
0
DISCUSSION
1
21
[ "B5", "B6", "B8", "B21", "B37", "B38" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
A recent report of L1 mobilization in a transgenic mouse model demonstrates higher L1 retrotransposition rates in somatic tissues than in the germ line (21), suggesting the possibility that expression of endogenous L1 elements in differentiated tissues may result in an appreciable amount of damage over time.
[ "5", "6", "8", "21", "37", "38" ]
309
37,511
1
false
A recent report of L1 mobilization in a transgenic mouse model demonstrates higher L1 retrotransposition rates in somatic tissues than in the germ line, suggesting the possibility that expression of endogenous L1 elements in differentiated tissues may result in an appreciable amount of damage over time.
[ "21" ]
A recent report of L1 mobilization in a transgenic mouse model demonstrates higher L1 retrotransposition rates in somatic tissues than in the germ line, suggesting the possibility that expression of endogenous L1 elements in differentiated tissues may result in an appreciable amount of damage over time.
true
true
true
true
true
6,424
0
DISCUSSION
1
5
[ "B5", "B6", "B8", "B21", "B37", "B38" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
Although FL L1 mRNAs are certainly the dominant source of L1 retrotransposition, generation of the SpORF2 transcript that can make functional ORF2 protein indicates that the FL L1 transcripts with both functional ORFs are not absolutely required to cause cellular damage.
[ "5", "6", "8", "21", "37", "38" ]
271
37,512
0
false
Although FL L1 mRNAs are certainly the dominant source of L1 retrotransposition, generation of the SpORF2 transcript that can make functional ORF2 protein indicates that the FL L1 transcripts with both functional ORFs are not absolutely required to cause cellular damage.
[]
Although FL L1 mRNAs are certainly the dominant source of L1 retrotransposition, generation of the SpORF2 transcript that can make functional ORF2 protein indicates that the FL L1 transcripts with both functional ORFs are not absolutely required to cause cellular damage.
true
true
true
true
true
6,424
0
DISCUSSION
1
5
[ "B5", "B6", "B8", "B21", "B37", "B38" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
This contrasts with previous assumptions that functional ORF2 protein can only be produced from the FL mRNAs (37,38).
[ "5", "6", "8", "21", "37", "38" ]
117
37,513
0
false
This contrasts with previous assumptions that functional ORF2 protein can only be produced from the FL mRNAs.
[ "37,38" ]
This contrasts with previous assumptions that functional ORF2 protein can only be produced from the FL mRNAs.
true
true
true
true
true
6,424
0
DISCUSSION
1
5
[ "B5", "B6", "B8", "B21", "B37", "B38" ]
20,215,437
pmid-1662412|pmid-11237011|pmid-11237011|pmid-15608246|pmid-8945518|pmid-8139560|pmid-7878012|pmid-12415270|pmid-18615728|pmid-16418485|pmid-8265584
It is apparent that detection of the L1 ORF2 protein does not necessarily guarantee the presence of the full-length L1 mRNA.
[ "5", "6", "8", "21", "37", "38" ]
124
37,514
0
false
It is apparent that detection of the L1 ORF2 protein does not necessarily guarantee the presence of the full-length L1 mRNA.
[]
It is apparent that detection of the L1 ORF2 protein does not necessarily guarantee the presence of the full-length L1 mRNA.
true
true
true
true
true
6,424
1
DISCUSSION
1
22
[ "B22", "B51", "B52", "B22" ]
20,215,437
pmid-8139560|pmid-7878012|pmid-15056671|pmid-12415270|pmid-17145770|pmid-2454389|pmid-15056671|pmid-15959507|pmid-19772661|pmid-19657334|pmid-16554555|pmid-14625551|pmid-1310068|pmid-16698926|pmid-17145770|pmid-15959507|pmid-17124176|pmid-16365384|pmid-18615728|pmid-12897783|pmid-14628287|pmid-10742098|pmid-12897783
Insertion of L1 elements is not the only mechanism by which they may damage genomes.
[ "22", "51", "52", "22" ]
84
37,515
0
false
Insertion of L1 elements is not the only mechanism by which they may damage genomes.
[]
Insertion of L1 elements is not the only mechanism by which they may damage genomes.
true
true
true
true
true
6,425