Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
paragraph_index
int64
sec
string
p_has_citation
int64
cites
string
citeids
list
pmid
int64
cited_id
string
sentences
string
all_sent_cites
list
sent_len
int64
sentence_batch_index
int64
sent_has_citation
float64
qc_fail
bool
cited_sentence
string
cites_in_sentence
list
cln_sentence
string
is_cap
bool
is_alpha
bool
ends_wp
bool
cit_qc
bool
lgtm
bool
__index_level_0__
int64
6
DISCUSSION
1
6
[ "B1", "B2", "B3", "B4", "B5", "B6" ]
20,457,752
pmid-10966471|pmid-18252769|pmid-3079749|pmid-4972364|pmid-9220965|pmid-8757127
(6) Gln-tRNAGln is released from GatDE.
[ "1", "2", "3", "4", "5", "6" ]
39
37,616
1
false
Gln-tRNAGln is released from GatDE.
[ "6" ]
Gln-tRNAGln is released from GatDE.
true
true
true
true
true
6,441
6
DISCUSSION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6" ]
20,457,752
pmid-10966471|pmid-18252769|pmid-3079749|pmid-4972364|pmid-9220965|pmid-8757127
For clarity only one GatDE monomer is shown.
[ "1", "2", "3", "4", "5", "6" ]
44
37,617
0
false
For clarity only one GatDE monomer is shown.
[]
For clarity only one GatDE monomer is shown.
true
true
true
true
true
6,441
7
DISCUSSION
1
10
[ "B10", "B13", "B15", "B13" ]
20,457,752
pmid-3340166|pmid-17964262|pmid-16809540|pmid-17964262
Both the archaeal-specific and T. thermophilus transamidosomes provide a means for mischarged tRNA generated by ND-aaRSs to be channeled to the AdT (10,13,15), keeping the mischarged tRNA from being recognized by elongation factors and compromising the fidelity of protein synthesis.
[ "10", "13", "15", "13" ]
283
37,618
0
false
Both the archaeal-specific and T. thermophilus transamidosomes provide a means for mischarged tRNA generated by ND-aaRSs to be channeled to the AdT, keeping the mischarged tRNA from being recognized by elongation factors and compromising the fidelity of protein synthesis.
[ "10,13,15" ]
Both the archaeal-specific and T. thermophilus transamidosomes provide a means for mischarged tRNA generated by ND-aaRSs to be channeled to the AdT, keeping the mischarged tRNA from being recognized by elongation factors and compromising the fidelity of protein synthesis.
true
true
true
true
true
6,442
7
DISCUSSION
1
13
[ "B10", "B13", "B15", "B13" ]
20,457,752
pmid-3340166|pmid-17964262|pmid-16809540|pmid-17964262
In addition, the T. thermophilus ND-AspRS:tRNAAsn:GatCAB complex is thought to protect Asn-tRNAAsn from deacylation until it can be used in translation (13).
[ "10", "13", "15", "13" ]
157
37,619
1
false
In addition, the T. thermophilus ND-AspRS:tRNAAsn:GatCAB complex is thought to protect Asn-tRNAAsn from deacylation until it can be used in translation.
[ "13" ]
In addition, the T. thermophilus ND-AspRS:tRNAAsn:GatCAB complex is thought to protect Asn-tRNAAsn from deacylation until it can be used in translation.
true
true
true
true
true
6,442
7
DISCUSSION
1
10
[ "B10", "B13", "B15", "B13" ]
20,457,752
pmid-3340166|pmid-17964262|pmid-16809540|pmid-17964262
The archaeal ND-GluRS:GatDE complex does not appear to carry out this function as the presence of both enzymes actually accelerated the deacylation rate of Gln-tRNAGln.
[ "10", "13", "15", "13" ]
168
37,620
0
false
The archaeal ND-GluRS:GatDE complex does not appear to carry out this function as the presence of both enzymes actually accelerated the deacylation rate of Gln-tRNAGln.
[]
The archaeal ND-GluRS:GatDE complex does not appear to carry out this function as the presence of both enzymes actually accelerated the deacylation rate of Gln-tRNAGln.
true
true
true
true
true
6,442
7
DISCUSSION
1
10
[ "B10", "B13", "B15", "B13" ]
20,457,752
pmid-3340166|pmid-17964262|pmid-16809540|pmid-17964262
Instead, the binding of GatDE to ND-GluRS appears to sequester the aaRS for Gln-tRNAGln formation.
[ "10", "13", "15", "13" ]
98
37,621
0
false
Instead, the binding of GatDE to ND-GluRS appears to sequester the aaRS for Gln-tRNAGln formation.
[]
Instead, the binding of GatDE to ND-GluRS appears to sequester the aaRS for Gln-tRNAGln formation.
true
true
true
true
true
6,442
7
DISCUSSION
1
10
[ "B10", "B13", "B15", "B13" ]
20,457,752
pmid-3340166|pmid-17964262|pmid-16809540|pmid-17964262
In the presence of GatDE, ND-GluRS has a much higher affinity for tRNAGln than tRNAGlu (>10-fold), while in the absence of the AdT, ND-GluRS has similar affinities for both tRNAs.
[ "10", "13", "15", "13" ]
179
37,622
0
false
In the presence of GatDE, ND-GluRS has a much higher affinity for tRNAGln than tRNAGlu, while in the absence of the AdT, ND-GluRS has similar affinities for both tRNAs.
[ ">10-fold" ]
In the presence of GatDE, ND-GluRS has a much higher affinity for tRNAGln than tRNAGlu, while in the absence of the AdT, ND-GluRS has similar affinities for both tRNAs.
true
true
true
true
true
6,442
7
DISCUSSION
1
10
[ "B10", "B13", "B15", "B13" ]
20,457,752
pmid-3340166|pmid-17964262|pmid-16809540|pmid-17964262
By increasing the concentration of GatDE relative to ND-GluRS, a cell can potentially favor Gln-tRNAGln formation over Glu-tRNAGlu.
[ "10", "13", "15", "13" ]
131
37,623
0
false
By increasing the concentration of GatDE relative to ND-GluRS, a cell can potentially favor Gln-tRNAGln formation over Glu-tRNAGlu.
[]
By increasing the concentration of GatDE relative to ND-GluRS, a cell can potentially favor Gln-tRNAGln formation over Glu-tRNAGlu.
true
true
true
true
true
6,442
8
DISCUSSION
1
29
[ "B29", "B12", "B30", "B31", "B32", "B33" ]
20,457,752
pmid-19417106|pmid-18522650|pmid-17321138|pmid-1451806|pmid-19187240|pmid-11726494
Sequestering GluRS in a complex for a particular role in a cell is not unusual.
[ "29", "12", "30", "31", "32", "33" ]
79
37,624
0
false
Sequestering GluRS in a complex for a particular role in a cell is not unusual.
[]
Sequestering GluRS in a complex for a particular role in a cell is not unusual.
true
true
true
true
true
6,443
8
DISCUSSION
1
29
[ "B29", "B12", "B30", "B31", "B32", "B33" ]
20,457,752
pmid-19417106|pmid-18522650|pmid-17321138|pmid-1451806|pmid-19187240|pmid-11726494
For example, in Saccharomyces cerevisiae Arc1p sequesters GluRS in the cytoplasm for Glu-tRNAGlu synthesis as otherwise the aaRS is targeted to the mitochondrion to be used with an AdT to form Gln-tRNAGln (29).
[ "29", "12", "30", "31", "32", "33" ]
210
37,625
1
false
For example, in Saccharomyces cerevisiae Arc1p sequesters GluRS in the cytoplasm for Glu-tRNAGlu synthesis as otherwise the aaRS is targeted to the mitochondrion to be used with an AdT to form Gln-tRNAGln.
[ "29" ]
For example, in Saccharomyces cerevisiae Arc1p sequesters GluRS in the cytoplasm for Glu-tRNAGlu synthesis as otherwise the aaRS is targeted to the mitochondrion to be used with an AdT to form Gln-tRNAGln.
true
true
true
true
true
6,443
8
DISCUSSION
1
12
[ "B29", "B12", "B30", "B31", "B32", "B33" ]
20,457,752
pmid-19417106|pmid-18522650|pmid-17321138|pmid-1451806|pmid-19187240|pmid-11726494
In chordates, GluRS is fused with the aaRS for Pro (GluProRS) and is part of the multi-synthetase complex (MSC) with seven other aaRSs for protein synthesis (12).
[ "29", "12", "30", "31", "32", "33" ]
162
37,626
1
false
In chordates, GluRS is fused with the aaRS for Pro (GluProRS) and is part of the multi-synthetase complex (MSC) with seven other aaRSs for protein synthesis.
[ "12" ]
In chordates, GluRS is fused with the aaRS for Pro (GluProRS) and is part of the multi-synthetase complex (MSC) with seven other aaRSs for protein synthesis.
true
true
true
true
true
6,443
8
DISCUSSION
1
30
[ "B29", "B12", "B30", "B31", "B32", "B33" ]
20,457,752
pmid-19417106|pmid-18522650|pmid-17321138|pmid-1451806|pmid-19187240|pmid-11726494
In humans upon phosphorylation, GluProRS is released from the MSC and associates with NS1-associated protein 1, ribosomal protein L13a, and glyceraldehyde-3-phosphate dehydrogenase to silence translation of certain mRNAs related to the inflammatory response (30).
[ "29", "12", "30", "31", "32", "33" ]
263
37,627
1
false
In humans upon phosphorylation, GluProRS is released from the MSC and associates with NS1-associated protein 1, ribosomal protein L13a, and glyceraldehyde-3-phosphate dehydrogenase to silence translation of certain mRNAs related to the inflammatory response.
[ "30" ]
In humans upon phosphorylation, GluProRS is released from the MSC and associates with NS1-associated protein 1, ribosomal protein L13a, and glyceraldehyde-3-phosphate dehydrogenase to silence translation of certain mRNAs related to the inflammatory response.
true
true
true
true
true
6,443
8
DISCUSSION
1
29
[ "B29", "B12", "B30", "B31", "B32", "B33" ]
20,457,752
pmid-19417106|pmid-18522650|pmid-17321138|pmid-1451806|pmid-19187240|pmid-11726494
In Chlamydomonas reinhardtii and Mycobacterium tuberculosis glutamyl-tRNA reductase (GluTR) binds GluRS likely to divert Glu-tRNAGlu synthesis from use in translation to tetrapyrrole biosynthesis (31,32).
[ "29", "12", "30", "31", "32", "33" ]
204
37,628
0
false
In Chlamydomonas reinhardtii and Mycobacterium tuberculosis glutamyl-tRNA reductase (GluTR) binds GluRS likely to divert Glu-tRNAGlu synthesis from use in translation to tetrapyrrole biosynthesis.
[ "31,32" ]
In Chlamydomonas reinhardtii and Mycobacterium tuberculosis glutamyl-tRNA reductase (GluTR) binds GluRS likely to divert Glu-tRNAGlu synthesis from use in translation to tetrapyrrole biosynthesis.
true
true
true
true
true
6,443
8
DISCUSSION
1
33
[ "B29", "B12", "B30", "B31", "B32", "B33" ]
20,457,752
pmid-19417106|pmid-18522650|pmid-17321138|pmid-1451806|pmid-19187240|pmid-11726494
Given that many archaea posses GluTR (33), there may be competition for binding with ND-GluRS between GatDE and GluTR.
[ "29", "12", "30", "31", "32", "33" ]
118
37,629
1
false
Given that many archaea posses GluTR, there may be competition for binding with ND-GluRS between GatDE and GluTR.
[ "33" ]
Given that many archaea posses GluTR, there may be competition for binding with ND-GluRS between GatDE and GluTR.
true
true
true
true
true
6,443
9
DISCUSSION
1
8
[ "B8", "B9", "B8", "B28", "B15", "B15", "B34", "B35" ]
20,457,752
pmid-18291416|pmid-10993083|pmid-18291416|pmid-18279892|pmid-16809540|pmid-16809540|pmid-17074748|pmid-17214986
In archaea, two AdTs are encoded to form the amide aa-tRNA species needed for translation (8); GatDE serves as the Glu-AdT (9) while GatCAB is the Asp-AdT (8).
[ "8", "9", "8", "28", "15", "15", "34", "35" ]
159
37,630
2
true
In archaea, two AdTs are encoded to form the amide aa-tRNA species needed for translation ; GatDE serves as the Glu-AdT while GatCAB is the Asp-AdT.
[ "8", "9", "8" ]
In archaea, two AdTs are encoded to form the amide aa-tRNA species needed for translation ; GatDE serves as the Glu-AdT while GatCAB is the Asp-AdT.
true
true
true
true
true
6,444
9
DISCUSSION
1
28
[ "B8", "B9", "B8", "B28", "B15", "B15", "B34", "B35" ]
20,457,752
pmid-18291416|pmid-10993083|pmid-18291416|pmid-18279892|pmid-16809540|pmid-16809540|pmid-17074748|pmid-17214986
It is still unclear what enabled such segregation of function, but phylogenetics suggests early archaea emerged from the last universal communal ancestor with both AdTs (28).
[ "8", "9", "8", "28", "15", "15", "34", "35" ]
174
37,631
1
false
It is still unclear what enabled such segregation of function, but phylogenetics suggests early archaea emerged from the last universal communal ancestor with both AdTs.
[ "28" ]
It is still unclear what enabled such segregation of function, but phylogenetics suggests early archaea emerged from the last universal communal ancestor with both AdTs.
true
true
true
true
true
6,444
9
DISCUSSION
1
15
[ "B8", "B9", "B8", "B28", "B15", "B15", "B34", "B35" ]
20,457,752
pmid-18291416|pmid-10993083|pmid-18291416|pmid-18279892|pmid-16809540|pmid-16809540|pmid-17074748|pmid-17214986
Consistent with our biochemical data, structural modeling indicates the insertion domain specific to GatE prevents GatDE from binding ND-AspRS while still being able to associate with ND-GluRS (15).
[ "8", "9", "8", "28", "15", "15", "34", "35" ]
198
37,632
1
false
Consistent with our biochemical data, structural modeling indicates the insertion domain specific to GatE prevents GatDE from binding ND-AspRS while still being able to associate with ND-GluRS.
[ "15" ]
Consistent with our biochemical data, structural modeling indicates the insertion domain specific to GatE prevents GatDE from binding ND-AspRS while still being able to associate with ND-GluRS.
true
true
true
true
true
6,444
9
DISCUSSION
1
8
[ "B8", "B9", "B8", "B28", "B15", "B15", "B34", "B35" ]
20,457,752
pmid-18291416|pmid-10993083|pmid-18291416|pmid-18279892|pmid-16809540|pmid-16809540|pmid-17074748|pmid-17214986
It is thus possible that the acquisition of the insertion domain by GatE may have favored GatDE serving as the Glu-AdT in early archaea as the AdT could complex with ND-GluRS but not ND-AspRS.
[ "8", "9", "8", "28", "15", "15", "34", "35" ]
192
37,633
0
false
It is thus possible that the acquisition of the insertion domain by GatE may have favored GatDE serving as the Glu-AdT in early archaea as the AdT could complex with ND-GluRS but not ND-AspRS.
[]
It is thus possible that the acquisition of the insertion domain by GatE may have favored GatDE serving as the Glu-AdT in early archaea as the AdT could complex with ND-GluRS but not ND-AspRS.
true
true
true
true
true
6,444
9
DISCUSSION
1
8
[ "B8", "B9", "B8", "B28", "B15", "B15", "B34", "B35" ]
20,457,752
pmid-18291416|pmid-10993083|pmid-18291416|pmid-18279892|pmid-16809540|pmid-16809540|pmid-17074748|pmid-17214986
Ancestral GatCAB however could still associate with ND-AspRS for tRNA-dependent Asn biosynthesis.
[ "8", "9", "8", "28", "15", "15", "34", "35" ]
97
37,634
0
false
Ancestral GatCAB however could still associate with ND-AspRS for tRNA-dependent Asn biosynthesis.
[]
Ancestral GatCAB however could still associate with ND-AspRS for tRNA-dependent Asn biosynthesis.
true
true
true
true
true
6,444
9
DISCUSSION
1
8
[ "B8", "B9", "B8", "B28", "B15", "B15", "B34", "B35" ]
20,457,752
pmid-18291416|pmid-10993083|pmid-18291416|pmid-18279892|pmid-16809540|pmid-16809540|pmid-17074748|pmid-17214986
Under such a scenario, the selective pressure to have a separate Glu-AdT and Asp-AdT would then have favored GatCAB as the Asp-AdT.
[ "8", "9", "8", "28", "15", "15", "34", "35" ]
131
37,635
0
false
Under such a scenario, the selective pressure to have a separate Glu-AdT and Asp-AdT would then have favored GatCAB as the Asp-AdT.
[]
Under such a scenario, the selective pressure to have a separate Glu-AdT and Asp-AdT would then have favored GatCAB as the Asp-AdT.
true
true
true
true
true
6,444
9
DISCUSSION
1
8
[ "B8", "B9", "B8", "B28", "B15", "B15", "B34", "B35" ]
20,457,752
pmid-18291416|pmid-10993083|pmid-18291416|pmid-18279892|pmid-16809540|pmid-16809540|pmid-17074748|pmid-17214986
Over time, GatDE would co-evolve with tRNAGln and ND-GluRS, and GatCAB with tRNAAsn and ND-AspRS, leading to the modern differences in tRNA recognition by the two archaeal AdTs (15,34,35).
[ "8", "9", "8", "28", "15", "15", "34", "35" ]
188
37,636
0
false
Over time, GatDE would co-evolve with tRNAGln and ND-GluRS, and GatCAB with tRNAAsn and ND-AspRS, leading to the modern differences in tRNA recognition by the two archaeal AdTs.
[ "15,34,35" ]
Over time, GatDE would co-evolve with tRNAGln and ND-GluRS, and GatCAB with tRNAAsn and ND-AspRS, leading to the modern differences in tRNA recognition by the two archaeal AdTs.
true
true
true
true
true
6,444
10
DISCUSSION
1
36
[ "B36", "B13", "B15", "B37" ]
20,457,752
pmid-42062|pmid-17964262|pmid-16809540|pmid-15823416
Caution must be taken with regard to whether the functions of the transamidosomes mentioned above were initially selected for.
[ "36", "13", "15", "37" ]
126
37,637
0
false
Caution must be taken with regard to whether the functions of the transamidosomes mentioned above were initially selected for.
[]
Caution must be taken with regard to whether the functions of the transamidosomes mentioned above were initially selected for.
true
true
true
true
true
6,445
10
DISCUSSION
1
36
[ "B36", "B13", "B15", "B37" ]
20,457,752
pmid-42062|pmid-17964262|pmid-16809540|pmid-15823416
For example, GatDE sequestering ND-GluRS and ND-AspRS:GatCAB protecting Asn-tRNAAsn from deacylation maybe evolutionary spandrels (36), a consequence perhaps of GluRS being a class I aaRS and AspRS being a class II enzyme as described above, with the actual selection to enable substrate channeling.
[ "36", "13", "15", "37" ]
299
37,638
1
false
For example, GatDE sequestering ND-GluRS and ND-AspRS:GatCAB protecting Asn-tRNAAsn from deacylation maybe evolutionary spandrels, a consequence perhaps of GluRS being a class I aaRS and AspRS being a class II enzyme as described above, with the actual selection to enable substrate channeling.
[ "36" ]
For example, GatDE sequestering ND-GluRS and ND-AspRS:GatCAB protecting Asn-tRNAAsn from deacylation maybe evolutionary spandrels, a consequence perhaps of GluRS being a class I aaRS and AspRS being a class II enzyme as described above, with the actual selection to enable substrate channeling.
true
true
true
true
true
6,445
10
DISCUSSION
1
36
[ "B36", "B13", "B15", "B37" ]
20,457,752
pmid-42062|pmid-17964262|pmid-16809540|pmid-15823416
Preventing mischarged tRNA from being used in protein synthesis may have also not been initially selected for.
[ "36", "13", "15", "37" ]
110
37,639
0
false
Preventing mischarged tRNA from being used in protein synthesis may have also not been initially selected for.
[]
Preventing mischarged tRNA from being used in protein synthesis may have also not been initially selected for.
true
true
true
true
true
6,445
10
DISCUSSION
1
36
[ "B36", "B13", "B15", "B37" ]
20,457,752
pmid-42062|pmid-17964262|pmid-16809540|pmid-15823416
It is speculated that aaRS:AdT complexes were the mechanisms by which Gln and Asn were added to the genetic code with the codons for Gln and Asn initially coding for Glu and Asp respectively (13,15,37).
[ "36", "13", "15", "37" ]
202
37,640
0
false
It is speculated that aaRS:AdT complexes were the mechanisms by which Gln and Asn were added to the genetic code with the codons for Gln and Asn initially coding for Glu and Asp respectively.
[ "13,15,37" ]
It is speculated that aaRS:AdT complexes were the mechanisms by which Gln and Asn were added to the genetic code with the codons for Gln and Asn initially coding for Glu and Asp respectively.
true
true
true
true
true
6,445
10
DISCUSSION
1
36
[ "B36", "B13", "B15", "B37" ]
20,457,752
pmid-42062|pmid-17964262|pmid-16809540|pmid-15823416
Thus, the initial selection for an aaRS:AdT complex may have been for RNA-dependent synthesis of Gln and Asn for translation, and preventing mischarged tRNA from being used for translation as a consequence of the association of the two enzymes.
[ "36", "13", "15", "37" ]
244
37,641
0
false
Thus, the initial selection for an aaRS:AdT complex may have been for RNA-dependent synthesis of Gln and Asn for translation, and preventing mischarged tRNA from being used for translation as a consequence of the association of the two enzymes.
[]
Thus, the initial selection for an aaRS:AdT complex may have been for RNA-dependent synthesis of Gln and Asn for translation, and preventing mischarged tRNA from being used for translation as a consequence of the association of the two enzymes.
true
true
true
true
true
6,445
0
INTRODUCTION
1
1
[ "B1", "B2" ]
16,361,819
pmid-8892078|pmid-9413255|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1690918|pmid-7598789|pmid-7937799
T cells, which are able to recognize myelin basic protein (MBP), are thought to play a major role in the pathophysiology of experimental autoimmune encephalomyelitis (EAE).
[ "1", "2" ]
172
37,642
0
false
T cells, which are able to recognize myelin basic protein (MBP), are thought to play a major role in the pathophysiology of experimental autoimmune encephalomyelitis (EAE).
[]
T cells, which are able to recognize myelin basic protein (MBP), are thought to play a major role in the pathophysiology of experimental autoimmune encephalomyelitis (EAE).
true
true
true
true
true
6,446
0
INTRODUCTION
1
1
[ "B1", "B2" ]
16,361,819
pmid-8892078|pmid-9413255|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1690918|pmid-7598789|pmid-7937799
They are activated in the periphery, and then migrate to the central nervous system (CNS), inducing autoimmune inflammation culminating in motor paralysis (1).
[ "1", "2" ]
159
37,643
1
false
They are activated in the periphery, and then migrate to the central nervous system (CNS), inducing autoimmune inflammation culminating in motor paralysis.
[ "1" ]
They are activated in the periphery, and then migrate to the central nervous system (CNS), inducing autoimmune inflammation culminating in motor paralysis.
true
true
true
true
true
6,446
0
INTRODUCTION
1
1
[ "B1", "B2" ]
16,361,819
pmid-8892078|pmid-9413255|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1690918|pmid-7598789|pmid-7937799
B10PL mice, when immunized with the acetylated N-terminal MBP peptide (MBP NAc 1-9), were found to generate encephalitogenic CD4+ T cell clones, which then migrated to the CNS, inducing EAE.
[ "1", "2" ]
190
37,644
0
false
B10PL mice, when immunized with the acetylated N-terminal MBP peptide, were found to generate encephalitogenic CD4+ T cell clones, which then migrated to the CNS, inducing EAE.
[ "MBP NAc 1-9" ]
B10PL mice, when immunized with the acetylated N-terminal MBP peptide, were found to generate encephalitogenic CD4+ T cell clones, which then migrated to the CNS, inducing EAE.
true
true
true
true
true
6,446
0
INTRODUCTION
1
2
[ "B1", "B2" ]
16,361,819
pmid-8892078|pmid-9413255|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1690918|pmid-7598789|pmid-7937799
Approximately 85% of encephalitogenic clones express the T cell receptor (TCR) VΞ²8.2 (2).
[ "1", "2" ]
89
37,645
1
false
Approximately 85% of encephalitogenic clones express the T cell receptor (TCR) VΞ²8.2.
[ "2" ]
Approximately 85% of encephalitogenic clones express the T cell receptor (TCR) VΞ²8.2.
true
true
true
true
true
6,446
1
INTRODUCTION
1
3
[ "B3", "B4", "B5", "B6", "B7", "B8", "B5" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
Therefore, an ideal therapy for EAE could involve selective inactivation, elimination, or functional deviation of the TCR VΞ²8.2.
[ "3", "4", "5", "6", "7", "8", "5" ]
128
37,646
0
false
Therefore, an ideal therapy for EAE could involve selective inactivation, elimination, or functional deviation of the TCR VΞ²8.2.
[]
Therefore, an ideal therapy for EAE could involve selective inactivation, elimination, or functional deviation of the TCR VΞ²8.2.
true
true
true
true
true
6,447
1
INTRODUCTION
1
3
[ "B3", "B4", "B5", "B6", "B7", "B8", "B5" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
Monoclonal antibodies targeted to pathogenic V gene products, as well as T-cell vaccination using peptides from the complementarity-determining regions of the pathogenic TCR V region, can induce resistance to the development of EAE (3).
[ "3", "4", "5", "6", "7", "8", "5" ]
236
37,647
1
false
Monoclonal antibodies targeted to pathogenic V gene products, as well as T-cell vaccination using peptides from the complementarity-determining regions of the pathogenic TCR V region, can induce resistance to the development of EAE.
[ "3" ]
Monoclonal antibodies targeted to pathogenic V gene products, as well as T-cell vaccination using peptides from the complementarity-determining regions of the pathogenic TCR V region, can induce resistance to the development of EAE.
true
true
true
true
true
6,447
1
INTRODUCTION
1
4
[ "B3", "B4", "B5", "B6", "B7", "B8", "B5" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
Unfortunately, peptide-based vaccines are poor immunogens (4).
[ "3", "4", "5", "6", "7", "8", "5" ]
62
37,648
1
false
Unfortunately, peptide-based vaccines are poor immunogens.
[ "4" ]
Unfortunately, peptide-based vaccines are poor immunogens.
true
true
true
true
true
6,447
1
INTRODUCTION
1
5
[ "B3", "B4", "B5", "B6", "B7", "B8", "B5" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
Genetic vaccinations with naked DNA have been reported to result in long-lasting cellular and humoral immune responses (5), and also, promote a shift in the pattern of cytokines produced by the pathogenic T cells (6).
[ "3", "4", "5", "6", "7", "8", "5" ]
217
37,649
1
false
Genetic vaccinations with naked DNA have been reported to result in long-lasting cellular and humoral immune responses, and also, promote a shift in the pattern of cytokines produced by the pathogenic T cells.
[ "5", "6" ]
Genetic vaccinations with naked DNA have been reported to result in long-lasting cellular and humoral immune responses, and also, promote a shift in the pattern of cytokines produced by the pathogenic T cells.
true
true
true
true
true
6,447
1
INTRODUCTION
1
7
[ "B3", "B4", "B5", "B6", "B7", "B8", "B5" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
Previous studies have indicated that intramuscular injection of VΞ²8.2 DNA in PL/J mice did not exhibit suppression of EAE development when they were immunized with whole MBP (7).
[ "3", "4", "5", "6", "7", "8", "5" ]
178
37,650
1
false
Previous studies have indicated that intramuscular injection of VΞ²8.2 DNA in PL/J mice did not exhibit suppression of EAE development when they were immunized with whole MBP.
[ "7" ]
Previous studies have indicated that intramuscular injection of VΞ²8.2 DNA in PL/J mice did not exhibit suppression of EAE development when they were immunized with whole MBP.
true
true
true
true
true
6,447
1
INTRODUCTION
1
8
[ "B3", "B4", "B5", "B6", "B7", "B8", "B5" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
The possibility exists that muscle was not considered to be a viable site for antigen presentation, as it contains few, if any, dendritic cells, macrophages, and lymphocytes (8).
[ "3", "4", "5", "6", "7", "8", "5" ]
178
37,651
1
false
The possibility exists that muscle was not considered to be a viable site for antigen presentation, as it contains few, if any, dendritic cells, macrophages, and lymphocytes.
[ "8" ]
The possibility exists that muscle was not considered to be a viable site for antigen presentation, as it contains few, if any, dendritic cells, macrophages, and lymphocytes.
true
true
true
true
true
6,447
1
INTRODUCTION
1
5
[ "B3", "B4", "B5", "B6", "B7", "B8", "B5" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
Furthermore, it has been well established that skin-associated lymphoid tissues harbor specialized cells which enhance immune responses, and that intradermal gene administration induces more profound immune responses than does intramuscular gene delivery (5).
[ "3", "4", "5", "6", "7", "8", "5" ]
259
37,652
1
false
Furthermore, it has been well established that skin-associated lymphoid tissues harbor specialized cells which enhance immune responses, and that intradermal gene administration induces more profound immune responses than does intramuscular gene delivery.
[ "5" ]
Furthermore, it has been well established that skin-associated lymphoid tissues harbor specialized cells which enhance immune responses, and that intradermal gene administration induces more profound immune responses than does intramuscular gene delivery.
true
true
true
true
true
6,447
1
INTRODUCTION
1
3
[ "B3", "B4", "B5", "B6", "B7", "B8", "B5" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
Therefore, the in vivo transfection of epidermal or dermal cells with DNA would be expected to constitute an efficient route for gene immunization.
[ "3", "4", "5", "6", "7", "8", "5" ]
147
37,653
0
false
Therefore, the in vivo transfection of epidermal or dermal cells with DNA would be expected to constitute an efficient route for gene immunization.
[]
Therefore, the in vivo transfection of epidermal or dermal cells with DNA would be expected to constitute an efficient route for gene immunization.
true
true
true
true
true
6,447
1
INTRODUCTION
1
3
[ "B3", "B4", "B5", "B6", "B7", "B8", "B5" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
This study was undertaken to determine the suppressive effects of intradermal gene vaccination with plasmid DNA encoding for VΞ²8.2 on the clinical outcome of EAE after immunization with whole rat MBP.
[ "3", "4", "5", "6", "7", "8", "5" ]
200
37,654
0
false
This study was undertaken to determine the suppressive effects of intradermal gene vaccination with plasmid DNA encoding for VΞ²8.2 on the clinical outcome of EAE after immunization with whole rat MBP.
[]
This study was undertaken to determine the suppressive effects of intradermal gene vaccination with plasmid DNA encoding for VΞ²8.2 on the clinical outcome of EAE after immunization with whole rat MBP.
true
true
true
true
true
6,447
0
DISCUSSION
1
5
[ "B5", "B6", "B7", "B13", "B14", "B5" ]
16,361,819
pmid-8892078|pmid-9413255|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1690918|pmid-7598789|pmid-7937799
The potential advantages associated with DNA vaccination include the prolonged, endogenous expression of antigens (5), long-term immunity with efficient generation of both CD8+ cytotoxic T cells and CD4+ T helper cells (6, 7), and the possibility of modulating Th1 or Th2 responses via the alteration of vaccination prot...
[ "5", "6", "7", "13", "14", "5" ]
331
37,655
1
false
The potential advantages associated with DNA vaccination include the prolonged, endogenous expression of antigens, long-term immunity with efficient generation of both CD8+ cytotoxic T cells and CD4+ T helper cells, and the possibility of modulating Th1 or Th2 responses via the alteration of vaccination protocols.
[ "5", "6, 7", "13" ]
The potential advantages associated with DNA vaccination include the prolonged, endogenous expression of antigens, long-term immunity with efficient generation of both CD8+ cytotoxic T cells and CD4+ T helper cells, and the possibility of modulating Th1 or Th2 responses via the alteration of vaccination protocols.
true
true
true
true
true
6,448
0
DISCUSSION
1
5
[ "B5", "B6", "B7", "B13", "B14", "B5" ]
16,361,819
pmid-8892078|pmid-9413255|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1690918|pmid-7598789|pmid-7937799
It has also been established that the in vivo transfection of the epidermis or dermal cells by DNA would be expected to provide an efficient route for gene immunization, due to immune response.
[ "5", "6", "7", "13", "14", "5" ]
193
37,656
0
false
It has also been established that the in vivo transfection of the epidermis or dermal cells by DNA would be expected to provide an efficient route for gene immunization, due to immune response.
[]
It has also been established that the in vivo transfection of the epidermis or dermal cells by DNA would be expected to provide an efficient route for gene immunization, due to immune response.
true
true
true
true
true
6,448
0
DISCUSSION
1
5
[ "B5", "B6", "B7", "B13", "B14", "B5" ]
16,361,819
pmid-8892078|pmid-9413255|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1690918|pmid-7598789|pmid-7937799
The present study sought to evaluate the effects of intradermal vaccination with DNA encoding for TCR VΞ²8.2, on the induction of EAE in B10.PL mice, after the mice had been immunized with whole MBP.
[ "5", "6", "7", "13", "14", "5" ]
198
37,657
0
false
The present study sought to evaluate the effects of intradermal vaccination with DNA encoding for TCR VΞ²8.2, on the induction of EAE in B10.PL mice, after the mice had been immunized with whole MBP.
[]
The present study sought to evaluate the effects of intradermal vaccination with DNA encoding for TCR VΞ²8.2, on the induction of EAE in B10.PL mice, after the mice had been immunized with whole MBP.
true
true
true
true
true
6,448
0
DISCUSSION
1
14
[ "B5", "B6", "B7", "B13", "B14", "B5" ]
16,361,819
pmid-8892078|pmid-9413255|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1690918|pmid-7598789|pmid-7937799
This study appears to have been extremely effective with regard to the induction of EAE after immunization, as reflected by the mean daily scores and mortality rate, even if the T-cell recognition of MBP p35-47 does not involve the VΞ²8.2 gene product (14).
[ "5", "6", "7", "13", "14", "5" ]
256
37,658
1
false
This study appears to have been extremely effective with regard to the induction of EAE after immunization, as reflected by the mean daily scores and mortality rate, even if the T-cell recognition of MBP p35-47 does not involve the VΞ²8.2 gene product.
[ "14" ]
This study appears to have been extremely effective with regard to the induction of EAE after immunization, as reflected by the mean daily scores and mortality rate, even if the T-cell recognition of MBP p35-47 does not involve the VΞ²8.2 gene product.
true
true
true
true
true
6,448
0
DISCUSSION
1
5
[ "B5", "B6", "B7", "B13", "B14", "B5" ]
16,361,819
pmid-8892078|pmid-9413255|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1690918|pmid-7598789|pmid-7937799
The results of our present study confirm the results of an earlier study, which reported that intradermal gene administration induced a more profound immune response than did intramuscular gene delivery (5).
[ "5", "6", "7", "13", "14", "5" ]
207
37,659
1
false
The results of our present study confirm the results of an earlier study, which reported that intradermal gene administration induced a more profound immune response than did intramuscular gene delivery.
[ "5" ]
The results of our present study confirm the results of an earlier study, which reported that intradermal gene administration induced a more profound immune response than did intramuscular gene delivery.
true
true
true
true
true
6,448
1
DISCUSSION
1
3
[ "B3", "B7", "B15", "B7", "B16", "B17", "B18" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
Although immunization with the TCR peptide (3) and vaccination with DNA (7, 15) also resulted in some protective effects on EAE development, little information is currently available regarding the mechanisms of action underlying the protection induced by DNA vaccination.
[ "3", "7", "15", "7", "16", "17", "18" ]
271
37,660
1
false
Although immunization with the TCR peptide and vaccination with DNA also resulted in some protective effects on EAE development, little information is currently available regarding the mechanisms of action underlying the protection induced by DNA vaccination.
[ "3", "7, 15" ]
Although immunization with the TCR peptide and vaccination with DNA also resulted in some protective effects on EAE development, little information is currently available regarding the mechanisms of action underlying the protection induced by DNA vaccination.
true
true
true
true
true
6,449
1
DISCUSSION
1
7
[ "B3", "B7", "B15", "B7", "B16", "B17", "B18" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
A previous study reported that DNA vaccination resulted in a Th1 to Th2 cytokine shift, and then the Th2 cytokines suppressed EAE development (7).
[ "3", "7", "15", "7", "16", "17", "18" ]
146
37,661
1
false
A previous study reported that DNA vaccination resulted in a Th1 to Th2 cytokine shift, and then the Th2 cytokines suppressed EAE development.
[ "7" ]
A previous study reported that DNA vaccination resulted in a Th1 to Th2 cytokine shift, and then the Th2 cytokines suppressed EAE development.
true
true
true
true
true
6,449
1
DISCUSSION
1
16
[ "B3", "B7", "B15", "B7", "B16", "B17", "B18" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
However, another previous study demonstrated that there were no signs of a Th2 cytokine bias, even if DNA vaccination did, indeed, suppress the development of EAE (16).
[ "3", "7", "15", "7", "16", "17", "18" ]
168
37,662
1
false
However, another previous study demonstrated that there were no signs of a Th2 cytokine bias, even if DNA vaccination did, indeed, suppress the development of EAE.
[ "16" ]
However, another previous study demonstrated that there were no signs of a Th2 cytokine bias, even if DNA vaccination did, indeed, suppress the development of EAE.
true
true
true
true
true
6,449
1
DISCUSSION
1
17
[ "B3", "B7", "B15", "B7", "B16", "B17", "B18" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
Furthermore, myelin/oligodendrocyte glycoprotein-induced EAE was aggravated after the induction of Th2 immunity (17).
[ "3", "7", "15", "7", "16", "17", "18" ]
117
37,663
1
false
Furthermore, myelin/oligodendrocyte glycoprotein-induced EAE was aggravated after the induction of Th2 immunity.
[ "17" ]
Furthermore, myelin/oligodendrocyte glycoprotein-induced EAE was aggravated after the induction of Th2 immunity.
true
true
true
true
true
6,449
1
DISCUSSION
1
18
[ "B3", "B7", "B15", "B7", "B16", "B17", "B18" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
In addition, IL-4-deficient mice, which exhibit defective Th2 responses, could be tolerant to the induction of EAE (18).
[ "3", "7", "15", "7", "16", "17", "18" ]
120
37,664
1
false
In addition, IL-4-deficient mice, which exhibit defective Th2 responses, could be tolerant to the induction of EAE.
[ "18" ]
In addition, IL-4-deficient mice, which exhibit defective Th2 responses, could be tolerant to the induction of EAE.
true
true
true
true
true
6,449
1
DISCUSSION
1
3
[ "B3", "B7", "B15", "B7", "B16", "B17", "B18" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
The results of a RT-PCR analysis on the total RNA samples extracted from the lymph node cells also demonstrated that vaccination did not induce a Th1-to-Th2 cytokine shift.
[ "3", "7", "15", "7", "16", "17", "18" ]
172
37,665
0
false
The results of a RT-PCR analysis on the total RNA samples extracted from the lymph node cells also demonstrated that vaccination did not induce a Th1-to-Th2 cytokine shift.
[]
The results of a RT-PCR analysis on the total RNA samples extracted from the lymph node cells also demonstrated that vaccination did not induce a Th1-to-Th2 cytokine shift.
true
true
true
true
true
6,449
1
DISCUSSION
1
3
[ "B3", "B7", "B15", "B7", "B16", "B17", "B18" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
In the case of MBP-induced immune response, we determined there to be no difference between the vaccination and control groups with regard to the response of IgG1 & IgG2a antibodies in the present study.
[ "3", "7", "15", "7", "16", "17", "18" ]
203
37,666
0
false
In the case of MBP-induced immune response, we determined there to be no difference between the vaccination and control groups with regard to the response of IgG1 & IgG2a antibodies in the present study.
[]
In the case of MBP-induced immune response, we determined there to be no difference between the vaccination and control groups with regard to the response of IgG1 & IgG2a antibodies in the present study.
true
true
true
true
true
6,449
1
DISCUSSION
1
3
[ "B3", "B7", "B15", "B7", "B16", "B17", "B18" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
This study indicated that intradermal vaccination with DNA encoding for TCR VΞ²8.2, in the case of EAE, did not induce a shift in cytokine response from Th1 to Th2.
[ "3", "7", "15", "7", "16", "17", "18" ]
163
37,667
0
false
This study indicated that intradermal vaccination with DNA encoding for TCR VΞ²8.2, in the case of EAE, did not induce a shift in cytokine response from Th1 to Th2.
[]
This study indicated that intradermal vaccination with DNA encoding for TCR VΞ²8.2, in the case of EAE, did not induce a shift in cytokine response from Th1 to Th2.
true
true
true
true
true
6,449
1
DISCUSSION
1
3
[ "B3", "B7", "B15", "B7", "B16", "B17", "B18" ]
16,361,819
pmid-8118876|pmid-8871642|pmid-7937799|pmid-11488667|pmid-8705850|pmid-1910679|pmid-7937799|pmid-8118876|pmid-8705850|pmid-9565646|pmid-8705850|pmid-8953031|pmid-9254649|pmid-7533645
Our findings were consistent with other recent studies, which reported that the shift from Th1 to Th2 cytokine responses is not directly involved in protective effects against EAE.
[ "3", "7", "15", "7", "16", "17", "18" ]
180
37,668
0
false
Our findings were consistent with other recent studies, which reported that the shift from Th1 to Th2 cytokine responses is not directly involved in protective effects against EAE.
[]
Our findings were consistent with other recent studies, which reported that the shift from Th1 to Th2 cytokine responses is not directly involved in protective effects against EAE.
true
true
true
true
true
6,449
2
DISCUSSION
1
19
[ "B19", "B20", "B5" ]
16,361,819
pmid-9509764|pmid-7857523|pmid-7937799
In order to determine whether the observed protective effects of gene vaccination were attributable to the deletion of T cells or to the induction of unresponsiveness, we examined the proliferation of lymph node cells in proportion to the MBP concentrations.
[ "19", "20", "5" ]
258
37,669
0
false
In order to determine whether the observed protective effects of gene vaccination were attributable to the deletion of T cells or to the induction of unresponsiveness, we examined the proliferation of lymph node cells in proportion to the MBP concentrations.
[]
In order to determine whether the observed protective effects of gene vaccination were attributable to the deletion of T cells or to the induction of unresponsiveness, we examined the proliferation of lymph node cells in proportion to the MBP concentrations.
true
true
true
true
true
6,450
2
DISCUSSION
1
19
[ "B19", "B20", "B5" ]
16,361,819
pmid-9509764|pmid-7857523|pmid-7937799
In our study, we determined that T cell proliferative responses against MBP in the vaccination group were partially suppressed, compared to those in the control group, but were higher in proportion to the MBP concentration.
[ "19", "20", "5" ]
223
37,670
0
false
In our study, we determined that T cell proliferative responses against MBP in the vaccination group were partially suppressed, compared to those in the control group, but were higher in proportion to the MBP concentration.
[]
In our study, we determined that T cell proliferative responses against MBP in the vaccination group were partially suppressed, compared to those in the control group, but were higher in proportion to the MBP concentration.
true
true
true
true
true
6,450
2
DISCUSSION
1
19
[ "B19", "B20", "B5" ]
16,361,819
pmid-9509764|pmid-7857523|pmid-7937799
T cell deletion has been observed primarily after the administration of high doses of antigens or peptides (19), and the presentation of antigens by nonprofessional antigen-presenting cells (APCs) which lack co-stimulatory capacity results in anergy, rather than in priming (20).
[ "19", "20", "5" ]
279
37,671
1
false
T cell deletion has been observed primarily after the administration of high doses of antigens or peptides, and the presentation of antigens by nonprofessional antigen-presenting cells (APCs) which lack co-stimulatory capacity results in anergy, rather than in priming.
[ "19", "20" ]
T cell deletion has been observed primarily after the administration of high doses of antigens or peptides, and the presentation of antigens by nonprofessional antigen-presenting cells (APCs) which lack co-stimulatory capacity results in anergy, rather than in priming.
true
true
true
true
true
6,450
2
DISCUSSION
1
5
[ "B19", "B20", "B5" ]
16,361,819
pmid-9509764|pmid-7857523|pmid-7937799
However, professional APCs, Langerhans cells, or macrophages, all of which are abundant in the dermis, may also function as APCs after intradermal DNA vaccinations (5).
[ "19", "20", "5" ]
168
37,672
1
false
However, professional APCs, Langerhans cells, or macrophages, all of which are abundant in the dermis, may also function as APCs after intradermal DNA vaccinations.
[ "5" ]
However, professional APCs, Langerhans cells, or macrophages, all of which are abundant in the dermis, may also function as APCs after intradermal DNA vaccinations.
true
true
true
true
true
6,450
2
DISCUSSION
1
19
[ "B19", "B20", "B5" ]
16,361,819
pmid-9509764|pmid-7857523|pmid-7937799
It is also possible that the intradermal gene vaccination in our study might not have induced either T cell deletion or anergy.
[ "19", "20", "5" ]
127
37,673
0
false
It is also possible that the intradermal gene vaccination in our study might not have induced either T cell deletion or anergy.
[]
It is also possible that the intradermal gene vaccination in our study might not have induced either T cell deletion or anergy.
true
true
true
true
true
6,450
3
DISCUSSION
1
21
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
Recently, it has been suggested that immunization with a tolerogenic form of the antigen induces the generation of regulatory CD4+CD25+ T cells, which, when activated either by the antigen or by anti-idiotype-bearing transducer suppressor cells, then served to mediate downmodulating T-helper effect functions on other a...
[ "21", "22", "23", "24", "25", "25", "25" ]
375
37,674
1
false
Recently, it has been suggested that immunization with a tolerogenic form of the antigen induces the generation of regulatory CD4+CD25+ T cells, which, when activated either by the antigen or by anti-idiotype-bearing transducer suppressor cells, then served to mediate downmodulating T-helper effect functions on other a...
[ "21" ]
Recently, it has been suggested that immunization with a tolerogenic form of the antigen induces the generation of regulatory CD4+CD25+ T cells, which, when activated either by the antigen or by anti-idiotype-bearing transducer suppressor cells, then served to mediate downmodulating T-helper effect functions on other a...
true
true
true
true
true
6,451
3
DISCUSSION
1
21
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
However, the specificity or mechanisms associated with regulatory CD4+ T cell-mediated suppression are not currently well understood.
[ "21", "22", "23", "24", "25", "25", "25" ]
133
37,675
0
false
However, the specificity or mechanisms associated with regulatory CD4+ T cell-mediated suppression are not currently well understood.
[]
However, the specificity or mechanisms associated with regulatory CD4+ T cell-mediated suppression are not currently well understood.
true
true
true
true
true
6,451
3
DISCUSSION
1
21
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
It has been reported, from earlier studies, that DNA vaccines are efficient inducers of regulatory CD8+ T cell-mediated immunity, and that CD8+ and MHC I-restricted effector T cells ultimately inhibit the function of encephalitogenic VΞ²8.2+ T cells (22, 23).
[ "21", "22", "23", "24", "25", "25", "25" ]
258
37,676
0
false
It has been reported, from earlier studies, that DNA vaccines are efficient inducers of regulatory CD8+ T cell-mediated immunity, and that CD8+ and MHC I-restricted effector T cells ultimately inhibit the function of encephalitogenic VΞ²8.2+ T cells.
[ "22, 23" ]
It has been reported, from earlier studies, that DNA vaccines are efficient inducers of regulatory CD8+ T cell-mediated immunity, and that CD8+ and MHC I-restricted effector T cells ultimately inhibit the function of encephalitogenic VΞ²8.2+ T cells.
true
true
true
true
true
6,451
3
DISCUSSION
1
21
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
Also, it is clear that the priming of the regulatory CD4 T cells must occur in a Th1 milieu for the effective regulation of anti-MBP responses, as well as protection from EAE.
[ "21", "22", "23", "24", "25", "25", "25" ]
175
37,677
0
false
Also, it is clear that the priming of the regulatory CD4 T cells must occur in a Th1 milieu for the effective regulation of anti-MBP responses, as well as protection from EAE.
[]
Also, it is clear that the priming of the regulatory CD4 T cells must occur in a Th1 milieu for the effective regulation of anti-MBP responses, as well as protection from EAE.
true
true
true
true
true
6,451
3
DISCUSSION
1
24
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
Furthermore, if the regulatory CD4+ T cells are compelled to deviate in the direction of Th2 direction, this would result in the exacerbation of the disease, due principally to the absence of the natural regulation provided by MBP-reactive T cells (24).
[ "21", "22", "23", "24", "25", "25", "25" ]
253
37,678
1
false
Furthermore, if the regulatory CD4+ T cells are compelled to deviate in the direction of Th2 direction, this would result in the exacerbation of the disease, due principally to the absence of the natural regulation provided by MBP-reactive T cells.
[ "24" ]
Furthermore, if the regulatory CD4+ T cells are compelled to deviate in the direction of Th2 direction, this would result in the exacerbation of the disease, due principally to the absence of the natural regulation provided by MBP-reactive T cells.
true
true
true
true
true
6,451
3
DISCUSSION
1
25
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
Recent reports suggest that protection from EAE after DNA vaccination is predicated on immunostimulatory, unmethylated CpG DNA motifs, and also that the underlying protective mechanism of DNA vaccination involves the immunomodulatory effects which are exerted by the induced IFN-Ξ², with no evidence for a shift in immune...
[ "21", "22", "23", "24", "25", "25", "25" ]
377
37,679
1
false
Recent reports suggest that protection from EAE after DNA vaccination is predicated on immunostimulatory, unmethylated CpG DNA motifs, and also that the underlying protective mechanism of DNA vaccination involves the immunomodulatory effects which are exerted by the induced IFN-Ξ², with no evidence for a shift in immune...
[ "25" ]
Recent reports suggest that protection from EAE after DNA vaccination is predicated on immunostimulatory, unmethylated CpG DNA motifs, and also that the underlying protective mechanism of DNA vaccination involves the immunomodulatory effects which are exerted by the induced IFN-Ξ², with no evidence for a shift in immune...
true
true
true
true
true
6,451
3
DISCUSSION
1
21
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
Also, IFN-Ξ² exerts anti-proliferative effects on peripheral blood monocytes.
[ "21", "22", "23", "24", "25", "25", "25" ]
76
37,680
0
false
Also, IFN-Ξ² exerts anti-proliferative effects on peripheral blood monocytes.
[]
Also, IFN-Ξ² exerts anti-proliferative effects on peripheral blood monocytes.
true
true
true
true
true
6,451
3
DISCUSSION
1
21
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
Our result demonstrated that the levels of mRNA expression of IFN-Ξ³, IL-2, IL-4, & IL-5 in the vaccination group were observed higher than in the control group without antigen-specific stimulation, but there were no differences in all of the cytokine expressions between the two groups after antigen-specific stimulation...
[ "21", "22", "23", "24", "25", "25", "25" ]
321
37,681
0
false
Our result demonstrated that the levels of mRNA expression of IFN-Ξ³, IL-2, IL-4, & IL-5 in the vaccination group were observed higher than in the control group without antigen-specific stimulation, but there were no differences in all of the cytokine expressions between the two groups after antigen-specific stimulation...
[]
Our result demonstrated that the levels of mRNA expression of IFN-Ξ³, IL-2, IL-4, & IL-5 in the vaccination group were observed higher than in the control group without antigen-specific stimulation, but there were no differences in all of the cytokine expressions between the two groups after antigen-specific stimulation...
true
true
true
true
true
6,451
3
DISCUSSION
1
25
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
This is consistent with the reports showing that DNA vaccination activated T cells, B cells and dendritic cells to produce a wide range of cytokines, but, DNA vaccination induced the immunomodulation effect on the EAE after antigen-specific stimulation (25).
[ "21", "22", "23", "24", "25", "25", "25" ]
258
37,682
1
false
This is consistent with the reports showing that DNA vaccination activated T cells, B cells and dendritic cells to produce a wide range of cytokines, but, DNA vaccination induced the immunomodulation effect on the EAE after antigen-specific stimulation.
[ "25" ]
This is consistent with the reports showing that DNA vaccination activated T cells, B cells and dendritic cells to produce a wide range of cytokines, but, DNA vaccination induced the immunomodulation effect on the EAE after antigen-specific stimulation.
true
true
true
true
true
6,451
3
DISCUSSION
1
21
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
Therfore, we have determined that intradermal DNA vaccination does not result in a shift from Th1 to Th2 cytokine responses, and also that T cell proliferative responses against MBP after DNA vaccination were suppressed, as compared to what we observed in the control group.
[ "21", "22", "23", "24", "25", "25", "25" ]
274
37,683
0
false
Therfore, we have determined that intradermal DNA vaccination does not result in a shift from Th1 to Th2 cytokine responses, and also that T cell proliferative responses against MBP after DNA vaccination were suppressed, as compared to what we observed in the control group.
[]
Therfore, we have determined that intradermal DNA vaccination does not result in a shift from Th1 to Th2 cytokine responses, and also that T cell proliferative responses against MBP after DNA vaccination were suppressed, as compared to what we observed in the control group.
true
true
true
true
true
6,451
3
DISCUSSION
1
25
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
This is consistent with earlier observations (25).
[ "21", "22", "23", "24", "25", "25", "25" ]
50
37,684
1
false
This is consistent with earlier observations.
[ "25" ]
This is consistent with earlier observations.
true
true
true
true
true
6,451
3
DISCUSSION
1
21
[ "B21", "B22", "B23", "B24", "B25", "B25", "B25" ]
16,361,819
pmid-11722629|pmid-11051274|pmid-12824465|pmid-12517939|pmid-15020066|pmid-15020066|pmid-15020066
Although the observed protective autoimmune mechanisms underlying DNA vaccination in our study have yet to be clearly established, we suggest that the mechanisms underlying intradermal vaccination with VΞ²8.2 DNA might be associated with the immunomodulation exerted by the induced IFN-Ξ².
[ "21", "22", "23", "24", "25", "25", "25" ]
287
37,685
0
false
Although the observed protective autoimmune mechanisms underlying DNA vaccination in our study have yet to be clearly established, we suggest that the mechanisms underlying intradermal vaccination with VΞ²8.2 DNA might be associated with the immunomodulation exerted by the induced IFN-Ξ².
[]
Although the observed protective autoimmune mechanisms underlying DNA vaccination in our study have yet to be clearly established, we suggest that the mechanisms underlying intradermal vaccination with VΞ²8.2 DNA might be associated with the immunomodulation exerted by the induced IFN-Ξ².
true
true
true
true
true
6,451
4
DISCUSSION
0
null
null
16,361,819
null
In summary, genetic immunization is associated with several advantages as compared with conventional vaccines, in that genetic immunization makes it possible to express antigens in forms which promote natural processing and presentation to lymphocytes.
null
252
37,686
0
false
null
null
In summary, genetic immunization is associated with several advantages as compared with conventional vaccines, in that genetic immunization makes it possible to express antigens in forms which promote natural processing and presentation to lymphocytes.
true
true
true
true
true
6,452
4
DISCUSSION
0
null
null
16,361,819
null
Furthermore, DNA vaccines are safe, stable, and induce long-lasting responses in host.
null
86
37,687
0
false
null
null
Furthermore, DNA vaccines are safe, stable, and induce long-lasting responses in host.
true
true
true
true
true
6,452
4
DISCUSSION
0
null
null
16,361,819
null
Our present study demonstrates that intradermal vaccination with DNA encoding for the VΞ²8.2 gene of the T-cell receptor might exert inhibitory effects on the induction of EAE in mice.
null
183
37,688
0
false
null
null
Our present study demonstrates that intradermal vaccination with DNA encoding for the VΞ²8.2 gene of the T-cell receptor might exert inhibitory effects on the induction of EAE in mice.
true
true
true
true
true
6,452
4
DISCUSSION
0
null
null
16,361,819
null
This study suggests that intradermal vaccination with DNA encoding for TCR might constitute a useful tool in the control of autoimmune disease.
null
143
37,689
0
false
null
null
This study suggests that intradermal vaccination with DNA encoding for TCR might constitute a useful tool in the control of autoimmune disease.
true
true
true
true
true
6,452
0
INTRODUCTION
1
1
[ "B1", "B2" ]
18,957,447
pmid-15143321|pmid-15014042
Mature microRNA (miRNA) molecules are approximately 22-nucleotide-long single-stranded RNAs that generally repress the expression of protein coding genes.
[ "1", "2" ]
154
37,690
0
false
Mature microRNA (miRNA) molecules are approximately 22-nucleotide-long single-stranded RNAs that generally repress the expression of protein coding genes.
[]
Mature microRNA (miRNA) molecules are approximately 22-nucleotide-long single-stranded RNAs that generally repress the expression of protein coding genes.
true
true
true
true
true
6,453
0
INTRODUCTION
1
1
[ "B1", "B2" ]
18,957,447
pmid-15143321|pmid-15014042
Specifically, they preferentially bind to 3β€² untranslated regions (UTRs) of messenger RNAs (mRNAs) and interfere with their stability and translational efficiency (1,2).
[ "1", "2" ]
169
37,691
0
false
Specifically, they preferentially bind to 3β€² untranslated regions (UTRs) of messenger RNAs (mRNAs) and interfere with their stability and translational efficiency.
[ "1,2" ]
Specifically, they preferentially bind to 3β€² untranslated regions (UTRs) of messenger RNAs (mRNAs) and interfere with their stability and translational efficiency.
true
true
true
true
true
6,453
1
INTRODUCTION
1
3–5
[ "B3 B4 B5" ]
18,957,447
pmid-11679670|pmid-11679671|pmid-11679672
The first miRNAs and their target genes were identified via classical forward genetic techniques in 1993, but it was not until 2001 that many more miRNAs were discovered experimentally and found to be abundant and widespread (3–5).
[ "3–5" ]
231
37,692
1
false
The first miRNAs and their target genes were identified via classical forward genetic techniques in 1993, but it was not until 2001 that many more miRNAs were discovered experimentally and found to be abundant and widespread.
[ "3–5" ]
The first miRNAs and their target genes were identified via classical forward genetic techniques in 1993, but it was not until 2001 that many more miRNAs were discovered experimentally and found to be abundant and widespread.
true
true
true
true
true
6,454
1
INTRODUCTION
1
3–5
[ "B3 B4 B5" ]
18,957,447
pmid-11679670|pmid-11679671|pmid-11679672
Since then there has been a dramatic growth in the number of annotated miRNAs (Figure 1).
[ "3–5" ]
89
37,693
0
false
Since then there has been a dramatic growth in the number of annotated miRNAs (Figure 1).
[]
Since then there has been a dramatic growth in the number of annotated miRNAs (Figure 1).
true
true
true
true
true
6,454
1
INTRODUCTION
1
3–5
[ "B3 B4 B5" ]
18,957,447
pmid-11679670|pmid-11679671|pmid-11679672
Figure 1.The growth of the human miRNA genes in mirBase database and the growth of the human experimentally determined miRNA target interactions in TarBase.
[ "3–5" ]
156
37,694
0
false
Figure 1.The growth of the human miRNA genes in mirBase database and the growth of the human experimentally determined miRNA target interactions in TarBase.
[]
Figure 1.The growth of the human miRNA genes in mirBase database and the growth of the human experimentally determined miRNA target interactions in TarBase.
true
true
true
true
true
6,454
2
INTRODUCTION
0
null
null
18,957,447
null
The growth of the human miRNA genes in mirBase database and the growth of the human experimentally determined miRNA target interactions in TarBase.
null
147
37,695
0
false
null
null
The growth of the human miRNA genes in mirBase database and the growth of the human experimentally determined miRNA target interactions in TarBase.
true
true
true
true
true
6,455
3
INTRODUCTION
1
6
[ "B6", "B7", "B8" ]
18,957,447
pmid-16736023|pmid-17060911|pmid-18668040
A crucial aspect of the functional analysis of miRNAs is the annotation of their protein-coding targets.
[ "6", "7", "8" ]
104
37,696
0
false
A crucial aspect of the functional analysis of miRNAs is the annotation of their protein-coding targets.
[]
A crucial aspect of the functional analysis of miRNAs is the annotation of their protein-coding targets.
true
true
true
true
true
6,456
3
INTRODUCTION
1
6
[ "B6", "B7", "B8" ]
18,957,447
pmid-16736023|pmid-17060911|pmid-18668040
A number of computational algorithms have been developed for the prediction of such targets (6).
[ "6", "7", "8" ]
96
37,697
1
false
A number of computational algorithms have been developed for the prediction of such targets.
[ "6" ]
A number of computational algorithms have been developed for the prediction of such targets.
true
true
true
true
true
6,456
3
INTRODUCTION
1
6
[ "B6", "B7", "B8" ]
18,957,447
pmid-16736023|pmid-17060911|pmid-18668040
Although these programs are very important to guide wet lab experiments, they still lack in sensitivity and specificity (7,8).
[ "6", "7", "8" ]
126
37,698
0
false
Although these programs are very important to guide wet lab experiments, they still lack in sensitivity and specificity.
[ "7,8" ]
Although these programs are very important to guide wet lab experiments, they still lack in sensitivity and specificity.
true
true
true
true
true
6,456
4
INTRODUCTION
0
null
null
18,957,447
null
In parallel, and as support for these programs, a number of experimental procedures have been developed to provide indirect or direct support for predicted miRNA–target interactions and results from a growing number of such experiments have been published (Figure 1).
null
267
37,699
0
false
null
null
In parallel, and as support for these programs, a number of experimental procedures have been developed to provide indirect or direct support for predicted miRNA–target interactions and results from a growing number of such experiments have been published (Figure 1).
true
true
true
true
true
6,457
5
INTRODUCTION
1
9
[ "B9" ]
18,957,447
pmid-16373484
The need for a systematic documentation of such experimentally supported targets was covered by the first version of TarBase (9).
[ "9" ]
129
37,700
1
false
The need for a systematic documentation of such experimentally supported targets was covered by the first version of TarBase.
[ "9" ]
The need for a systematic documentation of such experimentally supported targets was covered by the first version of TarBase.
true
true
true
true
true
6,458
5
INTRODUCTION
1
9
[ "B9" ]
18,957,447
pmid-16373484
In 2006, the database recorded over 550 entries with miRNA–target interactions in human, mouse, fruit fly, worm and zebrafish.
[ "9" ]
126
37,701
0
false
In 2006, the database recorded over 550 entries with miRNA–target interactions in human, mouse, fruit fly, worm and zebrafish.
[]
In 2006, the database recorded over 550 entries with miRNA–target interactions in human, mouse, fruit fly, worm and zebrafish.
true
true
true
true
true
6,458
5
INTRODUCTION
1
9
[ "B9" ]
18,957,447
pmid-16373484
Here we present a substantially updated and extended version of this database, TarBase5.0, documenting over 1300 entries.
[ "9" ]
121
37,702
0
false
Here we present a substantially updated and extended version of this database, TarBase5.0, documenting over 1300 entries.
[]
Here we present a substantially updated and extended version of this database, TarBase5.0, documenting over 1300 entries.
true
true
true
true
true
6,458
5
INTRODUCTION
1
9
[ "B9" ]
18,957,447
pmid-16373484
The new database now contains all of the information included in the previous version, plus: specific cells lines (if any) used in the experiments,cell-type-specific expression of the gene product and its potential involvement in carcinogenesis,differential expression of miRNAs in specific tissues,developmental or path...
[ "9" ]
522
37,703
0
false
The new database now contains all of the information included in the previous version, plus: specific cells lines (if any) used in the experiments,cell-type-specific expression of the gene product and its potential involvement in carcinogenesis,differential expression of miRNAs in specific tissues,developmental or path...
[]
The new database now contains all of the information included in the previous version, plus: specific cells lines (if any) used in the experiments,cell-type-specific expression of the gene product and its potential involvement in carcinogenesis,differential expression of miRNAs in specific tissues,developmental or path...
true
true
true
true
true
6,458
5
INTRODUCTION
1
9
[ "B9" ]
18,957,447
pmid-16373484
Additionally, both the underlying SQL database and the user interface have been extensively redesigned with several added external links such as a direct link to the paper's abstract on the PubMed site.
[ "9" ]
202
37,704
0
false
Additionally, both the underlying SQL database and the user interface have been extensively redesigned with several added external links such as a direct link to the paper's abstract on the PubMed site.
[]
Additionally, both the underlying SQL database and the user interface have been extensively redesigned with several added external links such as a direct link to the paper's abstract on the PubMed site.
true
true
true
true
true
6,458
6
INTRODUCTION
0
null
null
18,957,447
null
specific cells lines (if any) used in the experiments,
null
54
37,705
0
false
null
null
specific cells lines (if any) used in the experiments,
false
true
false
true
false
6,459
7
INTRODUCTION
0
null
null
18,957,447
null
cell-type-specific expression of the gene product and its potential involvement in carcinogenesis,
null
98
37,706
0
false
null
null
cell-type-specific expression of the gene product and its potential involvement in carcinogenesis,
false
true
false
true
false
6,460
8
INTRODUCTION
0
null
null
18,957,447
null
differential expression of miRNAs in specific tissues,
null
54
37,707
0
false
null
null
differential expression of miRNAs in specific tissues,
false
true
false
true
false
6,461
9
INTRODUCTION
0
null
null
18,957,447
null
developmental or pathological events that a specific miRNA is involved in and any annotated types of miRNA-related mis-regulation in those events,
null
146
37,708
0
false
null
null
developmental or pathological events that a specific miRNA is involved in and any annotated types of miRNA-related mis-regulation in those events,
false
true
false
true
false
6,462
10
INTRODUCTION
0
null
null
18,957,447
null
HGNC Symbols as defined by HUGO (in order to provide consistent gene naming).
null
77
37,709
0
false
null
null
HGNC Symbols as defined by HUGO (in order to provide consistent gene naming).
true
true
true
true
true
6,463
11
INTRODUCTION
0
null
null
18,957,447
null
The TarBase5.0 database can be directly accessed from the http://microrna.gr/tarbase web page.
null
94
37,710
0
false
null
null
The TarBase5.0 database can be directly accessed from the http://microrna.gr/tarbase web page.
true
true
true
true
true
6,464
0
INTRODUCTION
1
1–6
[ "B1 B2 B3 B4 B5 B6", "B1", "B6 B7 B8 B9", "B10", "B7", "B8", "B11" ]
18,558,617
pmid-6197186|pmid-11586922|pmid-12003490|pmid-16679018|NA|pmid-16595295|pmid-6197186|pmid-16595295|pmid-10393902|pmid-11233979|pmid-17284611|pmid-9847214|pmid-10393902|pmid-11233979|pmid-12431435|pmid-16595295|pmid-10393902|pmid-11233979|pmid-8022484|pmid-17081993|pmid-17284611
Ribonuclease P (RNase P) is an endoribonuclease responsible for the 5β€² maturation of tRNAs.
[ "1–6", "1", "6–9", "10", "7", "8", "11" ]
91
37,711
0
false
Ribonuclease P (RNase P) is an endoribonuclease responsible for the 5β€² maturation of tRNAs.
[]
Ribonuclease P (RNase P) is an endoribonuclease responsible for the 5β€² maturation of tRNAs.
true
true
true
true
true
6,465
0
INTRODUCTION
1
1–6
[ "B1 B2 B3 B4 B5 B6", "B1", "B6 B7 B8 B9", "B10", "B7", "B8", "B11" ]
18,558,617
pmid-6197186|pmid-11586922|pmid-12003490|pmid-16679018|NA|pmid-16595295|pmid-6197186|pmid-16595295|pmid-10393902|pmid-11233979|pmid-17284611|pmid-9847214|pmid-10393902|pmid-11233979|pmid-12431435|pmid-16595295|pmid-10393902|pmid-11233979|pmid-8022484|pmid-17081993|pmid-17284611
It is a ribonucleoprotein (RNP) complex containing one essential RNA (RNase P RNA; RPR) in all three domains of life and a varying number of protein subunits (RNase P Protein; RPP): one in bacteria, and at least four and nine in archaea and eukarya, respectively (1–6).
[ "1–6", "1", "6–9", "10", "7", "8", "11" ]
269
37,712
1
false
It is a ribonucleoprotein (RNP) complex containing one essential RNA (RNase P RNA; RPR) in all three domains of life and a varying number of protein subunits (RNase P Protein; RPP): one in bacteria, and at least four and nine in archaea and eukarya, respectively.
[ "1–6" ]
It is a ribonucleoprotein (RNP) complex containing one essential RNA (RNase P RNA; RPR) in all three domains of life and a varying number of protein subunits (RNase P Protein; RPP): one in bacteria, and at least four and nine in archaea and eukarya, respectively.
true
true
true
true
true
6,465
0
INTRODUCTION
1
1
[ "B1 B2 B3 B4 B5 B6", "B1", "B6 B7 B8 B9", "B10", "B7", "B8", "B11" ]
18,558,617
pmid-6197186|pmid-11586922|pmid-12003490|pmid-16679018|NA|pmid-16595295|pmid-6197186|pmid-16595295|pmid-10393902|pmid-11233979|pmid-17284611|pmid-9847214|pmid-10393902|pmid-11233979|pmid-12431435|pmid-16595295|pmid-10393902|pmid-11233979|pmid-8022484|pmid-17081993|pmid-17284611
The bacterial RPR is catalytically active in the absence of its RPP under in vitro conditions that include a high concentration of Mg2+ (or another suitable divalent metal ion) which is essential for catalysis (1).
[ "1–6", "1", "6–9", "10", "7", "8", "11" ]
214
37,713
1
false
The bacterial RPR is catalytically active in the absence of its RPP under in vitro conditions that include a high concentration of Mg2+ (or another suitable divalent metal ion) which is essential for catalysis.
[ "1" ]
The bacterial RPR is catalytically active in the absence of its RPP under in vitro conditions that include a high concentration of Mg2+ (or another suitable divalent metal ion) which is essential for catalysis.
true
true
true
true
true
6,465
0
INTRODUCTION
1
6–9
[ "B1 B2 B3 B4 B5 B6", "B1", "B6 B7 B8 B9", "B10", "B7", "B8", "B11" ]
18,558,617
pmid-6197186|pmid-11586922|pmid-12003490|pmid-16679018|NA|pmid-16595295|pmid-6197186|pmid-16595295|pmid-10393902|pmid-11233979|pmid-17284611|pmid-9847214|pmid-10393902|pmid-11233979|pmid-12431435|pmid-16595295|pmid-10393902|pmid-11233979|pmid-8022484|pmid-17081993|pmid-17284611
However, only a few representative archaeal and eukaryal RPRs are weakly active under various conditions tested in vitro (6–9).
[ "1–6", "1", "6–9", "10", "7", "8", "11" ]
127
37,714
1
false
However, only a few representative archaeal and eukaryal RPRs are weakly active under various conditions tested in vitro.
[ "6–9" ]
However, only a few representative archaeal and eukaryal RPRs are weakly active under various conditions tested in vitro.
true
true
true
true
true
6,465
0
INTRODUCTION
1
1–6
[ "B1 B2 B3 B4 B5 B6", "B1", "B6 B7 B8 B9", "B10", "B7", "B8", "B11" ]
18,558,617
pmid-6197186|pmid-11586922|pmid-12003490|pmid-16679018|NA|pmid-16595295|pmid-6197186|pmid-16595295|pmid-10393902|pmid-11233979|pmid-17284611|pmid-9847214|pmid-10393902|pmid-11233979|pmid-12431435|pmid-16595295|pmid-10393902|pmid-11233979|pmid-8022484|pmid-17081993|pmid-17284611
This result is surprising given the remarkable secondary structure similarity and conservation of nucleotide identity in the putative catalytic core in all RPRs and raises the possibility that not all RPRs are functionally equivalent (Figure 1A–C; 10).
[ "1–6", "1", "6–9", "10", "7", "8", "11" ]
252
37,715
0
false
This result is surprising given the remarkable secondary structure similarity and conservation of nucleotide identity in the putative catalytic core in all RPRs and raises the possibility that not all RPRs are functionally equivalent.
[ "Figure 1A–C; 10" ]
This result is surprising given the remarkable secondary structure similarity and conservation of nucleotide identity in the putative catalytic core in all RPRs and raises the possibility that not all RPRs are functionally equivalent.
true
true
true
true
true
6,465